Skip to main content

Jonathan Coquet Group

Jonathan Coquet laboratory website


1. Helper T cells : Generals of the immune response

The immune response has the challenge of responding to a broad variety of stimuli. From cancers to viruses, bacteria, worms and toxins, the type of response required to combat these threats differs. What may be a beneficial response in the context of a viral infection will not necessarily be effective to fight off bacteria. For this reason, the immune system needs to be flexible. One cell type in the immune system, known as the helper T cell is responsible for maintaining this flexibility. Helper T cells are known to differentiate into specialised subtypes with distinct functions and this divergence is controlled by various extracellular, intracellular and nuclear signals. My work focuses on characterising the involvement of helper T cells in diseases such as asthma and multiple sclerosis, and in finding novel pathways and proteins that regulate their differentiation.

Type 2 mediated inflammation in the airways leads to goblet cell metaplasia

2. The role of CD27-CD70 in chronic infection and cancer

Costimulatory pathways are critical regulators of immune homeostasis. Many chronic disorders are characterised by aberrant expression of costimulatory molecules. In particular, the TNF family member CD70 is expressed on malignant cells and in chronic viral infection and is proposed to negatively impact on immune function. We will study the mechanism by which this pathway may impede immune function, hopefully paving the way to novel treatments for chronic diseases.

Selected Publications

Multi-faceted inhibition of dendritic cell function by CD4Foxp3 regulatory T cells.
Seitz C, Liu S, Klocke K, Joly A, Czarnewski P, Tibbitt C, et al
J. Autoimmun. 2019 Mar;98():86-94

Atrophy of skin-draining lymph nodes predisposes for impaired immune responses to secondary infection in mice with chronic intestinal nematode infection.
Feng X, Classon C, Terán G, Yang Y, Li L, Chan S, et al
PLoS Pathog. 2018 05;14(5):e1007008

Factoring in CD4 T cells during treatment of HIV.
Coquet J
Immunol. Cell Biol. 2017 08;95(7):571-572

PPAR-γ promotes type 2 immune responses in allergy and nematode infection
Ting Chen, Christopher A. Tibbitt, Xiaogang Feng, Julian M. Stark, Leona Rohrbeck, Lisa Rausch, Saikiran K Sedimbi, Mikael C. I. Karlsson, Bart N. Lambrecht, Gunilla B. Karlsson Hedestam, Rudi W. Hendriks, Benedict J. Chambers, Susanne Nylén and Jonathan M. Coquet
Science Immunology 10 Mar 2017: Vol. 2, Issue 9, DOI: 10.1126/sciimmunol.aal5196
Read the full text article here

lck-Driven Cre Expression Alters T Cell Development in the Thymus and the Frequencies and Functions of Peripheral T Cell Subsets
Carow B, Gao Y, Coquet J, Reilly M, Rottenberg ME.
J Immunol. 2016 Sep 15;197(6):2261-8. doi: 10.4049/jimmunol.1600827

Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites.
Coquet J, Schuijs M, Smyth M, Deswarte K, Beyaert R, Braun H, et al
Immunity 2015 Aug;43(2):318-30

The importance of co-stimulation in the orchestration of T helper cell differentiation.
Coquet J, Rausch L, Borst J
Immunol. Cell Biol. 2015 Oct;93(9):780-8







We are always looking for enthusiastic researchers to join the group, so don’t be afraid to contact Jonathan Coquet on the email address below


Jonathan is supported by funding from the Swedish Research Council, Cancerfonden, KI foundations, Ollie and Elof Ericsson Stiftelse and Jeanssons stiftelse

Group members

Jonathan CoquetForskarassistent

08-524 869 52

Junjie MaForskarstuderande

Leona RohrbeckPostdoc

Julian StarkDoktorand, Forskarstuderande

08-524 869 46

Chris TibbittPostdoc

070-403 44 49