Elisabeth Norin Project
Anaerobic cultivated human intestinal microbiota (Achim)
Elisabeth Norin & Tore Midtvedt work with an anaerobic cultivated human intestinal microbiota (Achim). We have succeeded in re-cultivating – under strict conditions - ex vivo for more than 20 years - a diverse ecosystem of human intestinal microbiota from
a single healthy donor. In patients with recurrent Clostridium difficile infection (RCDI) this ecosystem is an excellent treatment option - to reestablish a functional microbiota - The study is still ongoing at the General Hospital in Gävle and in Oslo where patients after severaltreatment periods with different antimicrobials were randomly admitted to one of the two arms ”ACHIM TRANSPLANTATION” or ”VANCOMYCIN TREATMENT”. Most of the patients with RCDI so far included and thus treated have recovered.
Elisabeth Norin - Associate Professor
Tore Midtvedt - Professor emeritus
PhD, MD - Peter Benno and Bo Tjellström
A published book: "Gastrointestinal Microbiology"
Editors; Arthur C. Ouwehand Health and Nutrition, Danisco Finland, Finland, Elaine E. Vaughan Wageningen University, Vlaardingen, Netherlands.
Elisabeth Norin & Tore Midtvedt have written a chapter; "Born germ-free - microbial dependent"
Frederik E. Juul, Kjetil Garborg, Michael Bretthauer, Hilde Skudal, Mari N. Øines, Håvard Wiig, Øystein Rose, Birgitte Seip, J. Thomas Lamont, Tore Midtvedt, Jørgen Valeur, Mette Kalager, Øyvind Holme, Lise Helsingen, Magnus Løberg, Hans-Olov Adami. Fecal Microbiota Transplantation for Primary Clostridium
difficile Infection. The New England Journal of Medicine June2018. DOI: 10.1056/NEJMc1803103
PhD, MD Bo Tjellström