Anaesthesia and Intensive care

At the department of Anaesthesia and Intensive care, clinicians conduct research within the field of anesthesia/perioperative care and intensive care. The proximity of patient care enables identification of clinical important research questions as well as facilitates the implementation of recent/new research results.

The main goal of the research is to improve care, treatment and outcomes for the critically ill and/or operated patients through clinical studies. The department also holds a clinical research unit with two employed research nurses with high competence and experience in patient-centered clinical research, study monitoring and complex data collection and biobanking. The unit has a well-structured system for study monitoring and follow-up.

Research Group leaders

Anna Schandl

CCRN, PhD

Research group

Anca Balintescu, MD, PhD

Mattias Günther, MD, PhD

Eva Joelsson-Alm, CCRN, PhD

Christer Svensén, MD, PhD, Professor emeritus

Lena Swedberg, RN, PhD

Gisela Vogel, CCRN, PhD

Elisabeth Andersson, PhD Student

Anna Augustsén, PhD Student

Karin Berggren, PhD Student

Jacob Broms, PhD Student

Jens Christensen, PhD Student

Anna Granström, PhD Student

Ebba Hillstedt, PhD Student

Sandra Jonmarker, PhD Student

Li Yang, PhD Student

Fredric Sjöberg, PhD Student, research nurse

Elisabeth Hellgren, Research nurse

Collaborations

Alice Kane, Harvard University/University of Washington

Eric Thelin, Karolinska Universitetssjukhuset

CRIC nätverket

Denise Bäckström, KMC, Linköping Universitet 

Research projects

More study-specific information about each project can be found on the individual researcher’s profile page

Anaesthesia/perioperative care

Fluid therapy and hemodynamics – Rebecka Rubensson WahlinEva Joelsson-Alm, Christer Svensén

Airway management – Mattias Günther

Intensive care

Fluid treatment in sepsis and intensive care – Rebecka Rubenson Wahlin, Eva Joelsson-Alm

Diabetes in critically ill patients – Anca Balintescu

Long-term follow-up after critical illness –  Eva Joelsson-AlmAnna SchandlGisela Vogel

Treatment of critically ill patients with Covid-19 – Rebecka Rubensson Wahlin, Mattias Günther, Eva Joelsson-Alm, Anna Schandl, Christer Svensén

Oxygen project on septic pig – Mattias Günther, Christer Svensén

Emergency care/Prehospital care

Sepsis, early detection and treatment – Rebecka Rubenson WahlinEva Joelsson-Alm

Acute Assessment and Treatment of Traumatic Brain Injury – Rebecka Rubenson Wahlin

Sepsis, early detection and treatment in ambulance care – Rebecka Rubenson Wahlin

Acute assessment and treatment of TBI and geriatric trauma – Rebecka Rubenson Wahlin

Articles

Restriction of Intravenous Fluid in ICU Patients with Septic Shock.
Meyhoff TS, Hjortrup PB, Wetterslev J, Sivapalan P, Laake JH, Cronhjort M, Jakob SM, Cecconi M, Nalos M, Ostermann M, Malbrain M, Pettilä V, Møller MH, Kjær MN, Lange T, Overgaard-Steensen C, Brand BA, Winther-Olesen M, White JO, Quist L, Westergaard B, Jonsson AB, Hjortsø CJS, Meier N, Jensen TS, Engstrøm J, Nebrich L, Andersen-Ranberg NC, Jensen JV, Joseph NA, Poulsen LM, Herløv LS, Sølling CG, Pedersen SK, Knudsen KK, Straarup TS, Vang ML, Bundgaard H, Rasmussen BS, Aagaard SR, Hildebrandt T, Russell L, Bestle MH, Schønemann-Lund M, Brøchner AC, Elvander CF, Hoffmann SKL, Rasmussen ML, Martin YK, Friberg FF, Seter H, Aslam TN, Ådnøy S, Seidel P, Strand K, Johnstad B, Joelsson-Alm E, Christensen J, Ahlstedt C, Pfortmueller CA, Siegemund M, Greco M, Raděj J, Kříž M, Gould DW, Rowan KM, Mouncey PR, Perner A,
N Engl J Med 2022 Jun;386(26):2459-2470

Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia: The COVID STEROID 2 Randomized Trial.
, Munch MW, Myatra SN, Vijayaraghavan BKT, Saseedharan S, Benfield T, Wahlin RR, Rasmussen BS, Andreasen AS, Poulsen LM, Cioccari L, Khan MS, Kapadia F, Divatia JV, Brøchner AC, Bestle MH, Helleberg M, Michelsen J, Padmanaban A, Bose N, Møller A, Borawake K, Kristiansen KT, Shukla U, Chew MS, Dixit S, Ulrik CS, Amin PR, Chawla R, Wamberg CA, Shah MS, Darfelt IS, Jørgensen VL, Smitt M, Granholm A, Kjær MN, Møller MH, Meyhoff TS, Vesterlund GK, Hammond NE, Micallef S, Bassi A, John O, Jha A, Cronhjort M, Jakob SM, Gluud C, Lange T, Kadam V, Marcussen KV, Hollenberg J, Hedman A, Nielsen H, Schjørring OL, Jensen MQ, Leistner JW, Jonassen TB, Kristensen CM, Clapp EC, Hjortsø CJS, Jensen TS, Halstad LS, Bak ERB, Zaabalawi R, Metcalf-Clausen M, Abdi S, Hatley EV, Aksnes TS, Gleipner-Andersen E, Alarcón AF, Yamin G, Heymowski A, Berggren A, La Cour K, Weihe S, Pind AH, Engstrøm J, Jha V, Venkatesh B, Perner A
JAMA 2021 Nov;326(18):1807-1817

Long-term outcomes of dexamethasone 12 mg versus 6 mg in patients with COVID-19 and severe hypoxaemia.
Granholm A, Kjær MN, Munch MW, Myatra SN, Vijayaraghavan BKT, Cronhjort M, Wahlin RR, Jakob SM, Cioccari L, Vesterlund GK, Meyhoff TS, Helleberg M, Møller MH, Benfield T, Venkatesh B, Hammond NE, Micallef S, Bassi A, John O, Jha V, Kristiansen KT, Ulrik CS, Jørgensen VL, Smitt M, Bestle MH, Andreasen AS, Poulsen LM, Rasmussen BS, Brøchner AC, Strøm T, Møller A, Khan MS, Padmanaban A, Divatia JV, Saseedharan S, Borawake K, Kapadia F, Dixit S, Chawla R, Shukla U, Amin P, Chew MS, Wamberg CA, Bose N, Shah MS, Darfelt IS, Gluud C, Lange T, Perner A
Intensive Care Med 2022 May;48(5):580-589

Development of an ICU discharge instrument predicting psychological morbidity: a multinational study.
Milton A, Schandl A, Soliman IW, Meijers K, van den Boogaard M, Larsson IM, Brorsson C, Östberg U, Oxenbøll-Collet M, Savilampi J, Paskins S, Bottai M, Sackey PV
Intensive Care Med 2018 Dec;44(12):2038-2047

Intensive care nurses' lived experience of altruism and sacrifices during the Covid-19 pandemic: A phenomenological study.
Slettmyr A, Arman M, Andermo S, Malmberg C, Hällström Å, Hugelius K, Schandl A
J Adv Nurs 2023 Jan;79(1):244-253

Glycemic Control and Risk of Sepsis and Subsequent Mortality in Type 2 Diabetes.
Balintescu A, Lind M, Franko MA, Oldner A, Cronhjort M, Svensson AM, Eliasson B, Mårtensson J
Diabetes Care 2022 Jan;45(1):127-133

Stabilizing life: A grounded theory of surviving critical illness.
Vogel G, Joelsson-Alm E, Forinder U, Svensen C, Sandgren A
Intensive Crit Care Nurs 2021 Dec;67():103096

An observational study of intermediate- or high-dose thromboprophylaxis for critically ill COVID-19 patients.
Jonmarker S, Litorell J, Dahlberg M, Stackelberg O, Everhov ÅH, Söderberg M, Rubenson-Wahlin R, Günther M, Mårtensson J, Hollenberg J, Joelsson-Alm E, Cronhjort M
Acta Anaesthesiol Scand 2022 Mar;66(3):365-374

Family members' experiences of COVID-19 visiting restrictions in the intensive care unit-A qualitative study.
Forsberg T, Isaksson M, Schelin C, Lyngå P, Schandl A
J Clin Nurs 2023 Jan;():

Dosing of thromboprophylaxis and mortality in critically ill COVID-19 patients.
Jonmarker S, Hollenberg J, Dahlberg M, Stackelberg O, Litorell J, Everhov ÅH, Järnbert-Pettersson H, Söderberg M, Grip J, Schandl A, Günther M, Cronhjort M
Crit Care 2020 Nov;24(1):653