Mattias Günther

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About me

Anesthesiologist and Intensive Care physician at Södersjukhuset (Stockholm South General Hospital), and translational researcher in Experimental Traumatology.

• 2022 Scientific secretary, Centre for Trauma Research, Karolinska Institutet
• 2022 Section Editor for Disaster and Military Surgery, European Journal of Trauma and Emergency Surgery. Academic Editor, PLOS ONE Editorial Board.
• 2021 Associate Professor in Anesthesiology and Intensive Care
• 2021 Section Director of the Experimental Traumatology laboratory.
• 2019 Diplomate of the European Society of Anaesthesiology and Intensive Care, Brussels
• 2017 Specialist in Anesthesiology and Intensive Care, Swedish National Board of Health and Welfare
• 2015 PhD in Experimental Neurotrauma, Karolinska Institutet
• 2008 Licence to Practise, Swedish National Board of Health and Welfare
• 2006 University Medical Degree, Uppsala University

Research

My research focus is experimental traumatology in a defense medicine context, which includes trauma pathology, prehospital and intra-hospital treatment. The research targets increased survival through improved medical care at the site of injury and during subsequent care, specifically up to and during damage control surgery (NATO role 1 and role 2). We conduct research in three focus areas: prehospital care and protection, neurotrauma, and military medicine of the future. These include reducing avoidable deaths due to severe hemorrhage or lost airways, strategies to reduce death in traumatic brain injury, and reducing injury when wearing body armors or helmets (Behind Armor Blunt Trauma, BABT). Improved methods of airway control, bleeding control and patient stabilization are fundamental for successful casevacs to surgical care, which ultimately will improve survival, both in civilian and military settings.

Articles

Journal article: JOURNAL OF SURGICAL RESEARCH. 2025;314:580-588
Radiological Assessment of Abdominal Aortic and Junctional Tourniquet-Induced Ischemia and Organ Displacement in a Porcine Model
Luckhurst C; Brannstrom A; Gustavsson J; Gunther M
Journal article: SCIENTIFIC REPORTS. 2025;15(1):20295
Immunomodulation by extracorporeal ozone-based bactericide system in porcine Pseudomonas aeruginosa septic shock
Rundgren H; Sjoholm J; Juric S; Janson P; Kolerud J; Wallin R; Skorup P; Lipcsey M; Guenther M
Article: TRANSFUSION. 2025;65(Suppl 1):S68-S79
Intramuscular vasopressin: A feasible intervention for prehospital hemodynamic stabilization in porcine hemorrhagic shock and whole blood transfusion
Renberg M; Karlsson T; Gellerfors M; Gustavsson J; Wellfelt K; Gunther M
Article: INTENSIVE CARE MEDICINE EXPERIMENTAL. 2025;13(1):31
Expiratory ventilation assistance versus pressure-controlled ventilation with ambient oxygen in a hemorrhagic trauma model: a prehospital rescue option?
Karlsson T; Gustavsson J; Wellfelt K; Gunther M
Article: PHYSIOLOGICAL REPORTS. 2024;12(23):e70147
Eccentric exercise-induced muscle damage and inflammation in conjunction with high-altitude decompression in adults
Gottschalk F; Gennser M; Gunther M; Eiken O; Elia A
Article: EXPERIMENTAL PHYSIOLOGY. 2024;109(9):1517-1528
Eccentric exercise before a 90 min exposure at 24,000 ft increases decompression strain depending on body region but not total muscle mass recruited
Gottschalk F; Gennser M; Guenther M; Eiken O; Elia A
Article: EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY. 2024;50(4):1879-1889
The anesthesiologist's guide to swine trauma physiology research: a report of two decades of experience from the experimental traumatology laboratory
Renberg M; Karlsson T; Dahlquist A; Luckhurst C; Gustavsson J; Arborelius U; Risling M; Gunther M
Article: WORLD NEUROSURGERY. 2024;182:e493-e505
Increased Incidence and Mortality of Civilian Penetrating Traumatic Brain Injury in Sweden: A Single-Center Registry-Based Study
Lilford RD; Hossain I; Dahlberg M; Wahlgren C-M; Bellander B-M; Rostami A; Gunther M; Bartek J; Rostami E
Article: EUROPEAN JOURNAL OF MEDICAL RESEARCH. 2023;28(1):597
Improved oxygenation in prone positioning of mechanically ventilated patients with COVID-19 acute respiratory distress syndrome is associated with decreased pulmonary shunt fraction: a prospective multicenter study
Harbut P; Campoccia Jalde F; Dahlberg M; Forsgren A; Andersson E; Lundholm A; Janc J; Lesnik P; Suchanski M; Zatorski P; Trzebicki J; Skalec T; Gunther M
Article: ANNALS OF BIOMEDICAL ENGINEERING. 2023;51(12):2762-2771
An Experimental Cold Gas Cannon for the Study of Porcine Lung Contusion and Behind Armor Blunt Trauma
Karlsson T; Olsson L-G; Gustavsson J; Arborelius UP; Risling M; Guenther M
Article: SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE. 2023;31(1):85
Prehospital and emergency department airway management of severe penetrating trauma in Sweden during the past decade
Renberg M; Dahlberg M; Gellerfors M; Rostami E; Gunther M
Article: SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE. 2023;31(1):45
Prehospital transportation of severe penetrating trauma victims in Sweden during the past decade: a police business?
Renberg M; Dahlberg M; Gellerfors M; Rostami A; Gunther M; Rostami E
Article: EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY. 2023;49(3):1303-1313
Intermittent thoracic resuscitative endovascular balloon occlusion of the aorta improves renal function compared to 60 min continuous application after porcine class III hemorrhage
Brannstrom A; Hultstrom M; Gustavsson J; Aurfan Z; Gunther M
Article: TRANSFUSION. 2023;63:S213-S221
Permissive hypoventilation equally effective to maintain oxygenation as positive pressure ventilation after porcine class III hemorrhage and whole blood resuscitation
Karlsson T; Gellerfors M; Gustavsson J; Gunther M
Article: MILITARY MEDICAL RESEARCH. 2022;9(1):57
Comparison of emergency surgical cricothyroidotomy and percutaneous cricothyroidotomy by experienced airway providers in an obese, in vivo porcine hemorrhage airway model
Karlsson T; Brannstrom A; Gellerfors M; Gustavsson J; Gunther M
Article: INTENSIVE CARE MEDICINE EXPERIMENTAL. 2022;10(1):14
Evaluation of an extracorporeal ozone-based bactericide system for the treatment of Escherichia coli sepsis
Skorup P; Fransson A; Gustavsson J; Sjoholm J; Rundgren H; ozenci V; Wong AYW; Karlsson T; Svensen C; Gunther M
Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2022;66(3):365-374
An observational study of intermediate- or high-dose thromboprophylaxis for critically ill COVID-19 patients
Jonmarker S; Litorell J; Dahlberg M; Stackelberg O; Everhov AH; Soderberg M; Rubenson-Wahlin R; Gunther M; Martensson J; Hollenberg J; Joelsson-Alm E; Cronhjort M
Article: EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY. 2022;48(1):335-344
Increased crystalloid fluid requirements during zone 3 Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) versus Abdominal Aortic and Junctional Tourniquet (AAJT) after class II hemorrhage in swine
Brannstrom A; Dahlquist A; Gustavsson J; Arborelius UP; Gunther M
Article: EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY. 2022;48(1):401-409
Blast polytrauma with hemodynamic shock, hypothermia, hypoventilation and systemic inflammatory response: description of a new porcine model
Dahlquist A; Degerstedt LE; von Oelreich E; Brannstrom A; Gustavsson J; Arborelius UP; Gunther M
Article: ANNALS OF BIOMEDICAL ENGINEERING. 2022;50(1):78-85
An Experimental Model for the Study of Underwater Pressure Waves on the Central Nervous System in Rodents: A Feasibility Study
Gunther M; Arborelius U; Risling M; Gustavsson J; Sonden A
Article: FRONTIERS IN NEUROLOGY. 2021;12:730405
Incidence, Demographics, and Outcomes of Penetrating Trauma in Sweden During the Past Decade
Guenther M; Dahlberg M; Rostami A; Azadali A; Arborelius UP; Linder F; Rostami E
Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2021;65(9):1329-1336
Pre-hospital emergency anaesthesia in trauma patients treated by anaesthesiologist and nurse anaesthetist staffed critical care teams
Arnason B; Hertzberg D; Kornhall D; Gunther M; Gellerfors M
Article: PREHOSPITAL AND DISASTER MEDICINE. 2021;36(5):547-552
Pediatric Prehospital Advanced Airway Management by Anesthesiologist and Nurse Anesthetist Staffed Critical Care Teams
Renberg M; Hertzberg D; Kornhall D; Gunther M; Gellerfors M
Article: EXPERIMENTAL LUNG RESEARCH. 2021;47(7):323-333
Pulmonary hypoxia and venous admixture correlate linearly to the kinetic energy from porcine high velocity projectile behind armor blunt trauma
Arborelius UP; Rocksen D; Gustavsson J; Gunther M
Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2021;65(3):360-363
Prone positioning in mechanically ventilated patients with severe acute respiratory distress syndrome and coronavirus disease 2019
Gleissman H; Forsgren A; Andersson E; Lindqvist E; Lipka Falck A; Cronhjort M; Dahlberg M; Guenther M
Article: JOURNAL OF TRAUMA AND ACUTE CARE SURGERY. 2021;90(2):360-368
The swine as a vehicle for research in trauma-induced coagulopathy: Introducing principal component analysis for viscoelastic coagulation tests
Brannstrom A; von Oelreich E; Degerstedt LE; Dahlquist A; Hanell A; Gustavsson J; Gunther M
Article: CRITICAL CARE. 2020;24(1):653
Dosing of thromboprophylaxis and mortality in critically ill COVID-19 patients
Jonmarker S; Hollenberg J; Dahlberg M; Stackelberg O; Litorell J; Everhov AH; Jarnbert-Pettersson H; Soderberg M; Grip J; Schandl A; Gunther M; Cronhjort M
Article: EXPERIMENTAL LUNG RESEARCH. 2020;46(8):271-282
Severe, transient pulmonary ventilation-perfusion mismatch in the lung after porcine high velocity projectile behind armor blunt trauma
Rocksen D; Arborelius UP; Gustavsson J; Guenther M
Article: EXPERIMENTAL LUNG RESEARCH. 2020;46(5):117-127
Feasibility of pleural and perilesional subcutaneous microdialysis to assess porcine experimental pulmonary contusion
Guenther M; Sonden A; Gustavsson J; Arborelius UP; Rocksen D
Article: RESTORATIVE NEUROLOGY AND NEUROSCIENCE. 2020;38(1):23-40
Temporal gene expression changes after acute and delayed ventral root avulsion-reimplantation
Gunther M; Skold MK
Article: JOURNAL OF TRAUMA AND ACUTE CARE SURGERY. 2019;87(4):849-855
Transition from abdominal aortic and junctional tourniquet to zone 3 resuscitative endovascular balloon occlusion of the aorta is feasible with hemodynamic support after porcine class IV hemorrhage
Brannstrom A; Dahlquist A; Gustavsson J; Arborelius UP; Guenther M
Article: FRONTIERS IN NEUROLOGY. 2019;10:811
COX-2 Inhibition by Diclofenac Is Associated With Decreased Apoptosis and Lesion Area After Experimental Focal Penetrating Traumatic Brain Injury in Rats
Jadid KD; Davidsson J; Lidin E; Hanell A; Angeria M; Mathiesen T; Risling M; Gunther M
Article: JOURNAL OF CLINICAL NEUROSCIENCE. 2019;64:227-233
Brain tissue saving effects by single-dose intralesional administration of Neuroprotectin D1 on experimental focal penetrating brain injury in rats
Vanden Berg RW; Davidsson J; Lidin E; Angeria M; Risling M; Gunther M
Article: JOURNAL OF TRAUMA AND ACUTE CARE SURGERY. 2018;85(4):717-724
Abdominal Aortic and Junctional Tourniquet release after 240 minutes is survivable and associated with small intestine and liver ischemia after porcine class II hemorrhage
Brannstrom A; Rocksen D; Hartman J; Nyman N; Gustavsson J; Arborelius UP; Gunther M
Article: ENEURO. 2018;5(2):ENEURO.0335-ENEU17.2018
Susceptibility to Oxidative Stress Is Determined by Genetic Background in Neuronal Cell Cultures
Gunther M; Al Nimer F; Piehl F; Risling M; Mathiesen T
Article: JOURNAL OF CLINICAL NEUROSCIENCE. 2015;22(9):1477-1483
Neuroprotective effects of N-acetylcysteine amide on experimental focal penetrating brain injury in rats
Gunther M; Davidsson J; Plantman S; Norgren S; Mathiesen T; Risling M
Article: ACTA NEUROCHIRURGICA. 2015;157(4):649-659
COX-2 regulation and TUNEL-positive cell death differ between genders in the secondary inflammatory response following experimental penetrating focal brain injury in rats
Gunther M; Plantman S; Davidsson J; Angeria M; Mathiesen T; Risling M
Article: ACTA NEUROCHIRURGICA. 2014;156(12):2365-2378
Shock wave trauma leads to inflammatory response and morphological activation in macrophage cell lines, but does not induce iNOS or NO synthesis
Gunther M; Plantman S; Gahm C; Sonden A; Risling M; Mathiesen T
Article: ACTA NEUROCHIRURGICA. 2012;154(4):689-697
iNOS-mediated secondary inflammatory response differs between rat strains following experimental brain contusion
Guenther M; Al Nimer F; Gahm C; Piehl F; Mathiesen T
Article: OTOLOGY & NEUROTOLOGY. 2010;31(9):1493-1497
Surgical Treatment of Patients With Facial Neuromas-A Report of 26 Consecutive Operations
Gunther M; Danckwardt-Lilliestrom N; Gudjonsson O; Nyberg G; Kinnefors A; Rask-Andersen H; Ekvall L
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All other publications

Preprint: MEDRXIV. 2020
Dosing Of Thromboprophylaxis And Mortality In Critically Ill Covid-19 Patients
Jonmarker S; Hollenberg J; Dahlberg M; Stackelberg O; Litorell J; Everhov Å; Järnbert-Pettersson H; Söderberg M; Grip J; Schandl A; Günther M; Cronhjort M
Letter: JOURNAL OF TRAUMA AND ACUTE CARE SURGERY. 2019;87(3):741
Reply to letter: Kheirabadi et al. Long-term consequences of abdominal aortic and junctional tourniquet for hemorrhage control
Gunther M; Brannstrom A
Conference publication: JOURNAL OF NEUROTRAUMA. 2016;33(3):A12-A13
VENTRAL ROOT AVULSION AND REPLANTATION - DESCRIPTION OF DIFFERENT GENE EXPRESSION PATTERNS IN ACUTE AND DELAYED REPLANTATION
Skold M; Gunther M
Doctoral thesis: 2015
Oxidative stress in experimental traumatic brain injury
Günther M
Conference publication: JOURNAL OF NEUROTRAUMA. 2014;31(5):A18
COX-2 REGULATION DIFFERS BETWEEN SEXES IN THE SECONDARY INFLAMMATORY RESPONSE FOLLOWING EXPERIMENTAL PENETRATING FOCAL BRAIN INJURY IN RATS
Gunther M; Plantman S; Davidsson J; Angeria M; Mathiesen T; Risling M
Conference publication: JOURNAL OF NEUROTRAUMA. 2013;30(15):A93-A94
COX-2 REGULATION DIFFERS BETWEEN SEXES IN THE SECONDARY INFLAMMATORY RESPONSE FOLLOWING EXPERIMENTAL PENETRATING BRAIN INJURY IN RATS
Gunther M; Plantman S; Angeria M; Mathiesen T; Risling M
Conference publication: BRAIN INJURY. 2012;26(4-5):368
iNOS mediated secondary inflammatory response differs between rat strains following experimental brain contusion
Gunther M; Al Nimer F; Gahm C; Mathiesen T

Employments

Principal Researcher, Department of Neuroscience, Karolinska Institutet, 2022-
Affiliated to Research, Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, 2023-2026

Degrees and Education

Docent, Karolinska Institutet, 2021
Degree Of Doctor Of Philosophy, Department of neuroscience, Karolinska Institutet, 2015

Supervision

Supervision to doctoral degree
- Frode Gottschalk, The effect of eccentric exercise on decompression strain, https://openarchive.ki.se/articles/thesis/The_effect_of_eccentric_exercise_on_decompression_strain/27620190?file=50253024, 2024

About me

Research

Articles

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Degrees and Education

Supervision

Supervision to doctoral degree

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