NutriLab – Janina Seubert's Research Group

The nutritional neuroscience group investigates the perceptual experiences associated with eating. We study odor and taste perception during anticipation and consumption of food, their effects on memory and learning as well as emotion and motivation, and their regulation by metabolic feedback.

More from the Nutrilab

Our research

The main goal of our research is to improve our understanding of the psychological and neural mechanisms of perceptual food experience and learn how they influence our evaluation of different food choices. We hope our work can thereby inspire the development of new interventions that facilitate dietary changes over the course of life and in health and disease. 

We are currently pursuing this goal in three different projects:

1. Olfaction as a link between flavour preference and food consumption

Child smelling a cake
Photo: Daria Junger

Human food consumption habits globally pose a significant threat to public health and ecological sustainability. Awareness of the urgency for large-scale global changes has recently been growing substantially; yet, overcoming preferences for familiar food flavors in favor of healthier or more sustainable options remains a major challenge. 

The high intrinsic reward value of taste, especially sugar and salt, is generally blamed for the resistance of humans to change their food preferences. There is, however, a fundamental lack of knowledge about the perceptual and emotional mechanisms that link these reward experiences during consumption to the identification of desirable food items before consumption, which ultimately drive our appetite and our dietary decisions. 

Photo: ERC

 

This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 947886).

2. Perceptual decision-making about food flavor in the mouth, and its role in food intake regulation

Every time we eat, we evaluate the flavor of the food in our mouth: is it a safe source of energy that should be swallowed, or a potential health threat that should be spit out? Getting this simple decision right is crucial for survival, because it allows us to maintain the balance between sufficient calorie intake on the one hand, and avoidance of accidental poisoning on the other.

Person eating.
Photo: Beth Macdonald

It is well established that we accept foods when their flavor fits a familiar and expected object and reject them when it does not. How we decide whether a flavor belongs to a specific object, however, and which brain processes regulate these decisions, remains to date poorly understood. This project will explore the perceptual and brain processes that allow us to classify olfactory-gustatory percepts in the mouth into stable object categories. Taken together, the knowledge gained from this project will provide us with important insights into the psychological mechanisms that control our perception of the food we eat, and how we use this information to regulate the desire for eating in specific situations in everyday life.

3. Dysregulated Anticipatory Reward Processing in Eating Disorders

Person eating.
Photo: Annie Spratt

Eating disorders have high morbidity and mortality and outcome, especially in anorexia nervosa, is poor, in part due to incomplete understanding of their underlying neurobiology. Neurobiological factors could thwart interventions by affecting the automatic elicitation of reward seeking behavior to food. Odor perception, a key elicitor of responses to foods, could provide novel insights into disturbances of brain reward circuitry in eating disorders. In this collaboration with Cynthia Bulik (Centre for Eating Disorders Innovation, Karolinska Institute) and Ata Ghaderi (Department for Clinical Neuroscience, Karolinska Institute) we explore dysregulated food odor processing in binge eating disorder (uncontrolled overeating) and Anorexia nervosa.

Publications

Selected publications

Article: FOOD QUALITY AND PREFERENCE. 2024;119:105211

Dissociable effects of hunger, exposure and sensory overlap on flavour liking

Khorisantono PA; Fondberg R; Lundstrom JN; Seubert J

Article: CORTEX. 2021;139:198-210

Trimodal processing of complex stimuli in inferior parietal cortex is modality-independent

Porada DK; Regenbogen C; Freiherr J; Seubert J; Lundstrom JN

Article: CHEMICAL SENSES. 2021;46:bjab003

Odor-Taste Interactions in Food Perception: Exposure Protocol Shows No Effects of Associative Learning

Fondberg R; Lundstrom JN; Seubert J

Article: NEUROIMAGE. 2020;211:116600

Temporolimbic cortical volume is associated with semantic odor memory performance in aging

Seubert J; Kalpouzos G; Larsson M; Hummel T; Backman L; Laukka EJ

Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2020;75(3):603-610

A Prospective Study on Risk Factors for Olfactory Dysfunction in Aging

Palmquist E; Larsson M; Olofsson JK; Seubert J; Backman L; Laukka EJ

Article: NEUROSCIENCE. 2019;418:254-265

Multisensory Enhancement of Odor Object Processing in Primary Olfactory Cortex

Porada DK; Regenbogen C; Seubert J; Freiherr J; Lundstrom JN

Article: CEREBRAL CORTEX. 2019;29(7):3023-3033

Prefrontal Control Over Occipital Responses to Crossmodal Overlap Varies Across the Congruency Spectrum

Lundstrom JN; Regenbogen C; Ohla K; Seubert J

Article: NEUROLOGY. 2019;92(7):e700-e709

Impaired olfaction is associated with cognitive decline and neurodegeneration in the brain

Dintica CS; Marseglia A; Rizzuto D; Wang R; Seubert J; Arfanakis K; Bennett DA; Xu W

Journal article: ALZHEIMERS & DEMENTIA. 2018;14(7S_Part_4):p248-p249

O1‐11‐06: IMPAIRED OLFACTORY FUNCTION IS ASSOCIATED WITH ACCELERATED COGNITIVE DECLINE AND NEURODEGENERATION IN THE BRAIN

Dintica CS; Marseglia A; Rizzuto D; Wang R; Seubert J; Bennett DA; Xu W

Article: APPETITE. 2018;125:244-252

Multisensory flavor perception: The relationship between congruency, pleasantness, and odor referral to the mouth

Fondberg R; Lundstrom JN; Bloechl M; Olsson MJ; Seubert J

Article: HUMAN BRAIN MAPPING. 2018;39(3):1313-1326

The intraparietal sulcus governs multisensory integration of audiovisual information based on task difficulty

Regenbogen C; Seubert J; Johansson E; Finkelmeyer A; Andersson P; Lundstrom JN

Article: EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY. 2017;119(12)

Lipids in Eating and Appetite Regulation - A Neuro-Cognitive Perspective

Borg S; Seubert J

Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2017;72(8):1072-1079

Prevalence and Correlates of Olfactory Dysfunction in Old Age: A Population-Based Study

Seubert J; Laukka EJ; Rizzuto D; Hummel T; Fratiglioni L; Backman L; Larsson M

Article: CHEMICAL SENSES. 2017;42(4):309-318

Phantom Smells: Prevalence and Correlates in a Population-Based Sample of Older Adults

Sjolund S; Larsson M; Olofsson JK; Seubert J; Laukka EJ

Article: NEUROBIOLOGY OF AGING. 2016;38:118-126

Olfactory memory in the old and very old: relations to episodic and semantic memory and APOE genotype

Larsson M; Hedner M; Papenberg G; Seubert J; Backman L; Laukka EJ

Article: HUMAN BRAIN MAPPING. 2015;36(5):1662-1676

Superadditive Opercular Activation to Food Flavor is Mediated by Enhanced Temporal and Limbic Coupling

Seubert J; Ohla K; Yokomukai Y; Kellermann T; Lundstrom JN

Article: BRITISH JOURNAL OF PSYCHIATRY. 2015;206(3):198-205

Neural responses to dynamic multimodal stimuli and pathology-specific impairments of social cognition in schizophrenia and depression

Regenbogen C; Kellermann T; Seubert J; Schneider DA; Gur RE; Derntl B; Schneider F; Habel U

Article: PLOS ONE. 2014;9(5):e98347

Odor Valence Linearly Modulates Attractiveness, but Not Age Assessment, of Invariant Facial Features in a Memory-Based Rating Task

Seubert J; Gregory KM; Chamberland J; Dessirier J-M; Lundstroem JN

Article: CEREBRAL CORTEX. 2013;23(10):2448-2456

Orbitofrontal Cortex and Olfactory Bulb Volume Predict Distinct Aspects of Olfactory Performance in Healthy Subjects

Seubert J; Freiherr J; Frasnelli J; Hummel T; Lundstroem JN

Article: NEUROIMAGE. 2013;66:333-342

Statistical localization of human olfactory cortex

Seubert J; Freiherr J; Djordjevic J; Lundstroem JN

Article: BRAIN AND COGNITION. 2011;76(3):353-363

Opposing amygdala and ventral striatum connectivity during emotion identification

Satterthwaite TD; Wolf DH; Pinkham AE; Ruparel K; Elliott MA; Valdez JN; Overton E; Seubert J; Gur RE; Gur RC; Loughead J

Article: NEUROIMAGE. 2010;53(2):746-756

Processing of disgusted faces is facilitated by odor primes: A functional MRI study

Seubert J; Kellermann T; Loughead J; Boers F; Brensinger C; Schneider F; Habel U

Article: JOURNAL OF PSYCHIATRY & NEUROSCIENCE. 2010;35(3):185-194

Multisensory integration of emotionally valenced olfactory-visual information in patients with schizophrenia and healthy controls

Seubert J; Loughead J; Kellermann T; Boers F; Brensinger CM; Habel U

Journal article: NEUROIMAGE. 2009;47:s182

Neural correlates of olfactory-visual interactions in emotion processing

Seubert J; Kellermann T; Boers F; Loughead J; Habel U

Article: SCHIZOPHRENIA BULLETIN. 2009;35(4):816-825

Extended Visual Simultaneity Thresholds in Patients With Schizophrenia

Giersch A; Lalanne L; Corves C; Seubert J; Shi Z; Foucher J; Elliott MA

Article: CHEMICAL SENSES. 2009;34(1):77-84

Mood Induction with Olfactory Stimuli Reveals Differential Affective Responses in Males and Females

Seubert J; Rea AF; Loughead J; Habel U

Article: NEUROCASE. 2008;14(2):204-219

Straight after the turn:: The role of the parietal lobes in egocentric space processing

Seubert J; Humphreys GW; Mueller HJ; Gramann K

Journal article: SCHIZOPHRENIA RESEARCH. 2008;102(1-3):119

EXTENDED VISUAL SIMULTANEITY THRESHOLDS IN PATIENTS WITH SCHIZOPHRENIA

Elliott M; Lalanne L; Corves C; Seubert J; Foucher J; Giersch A

Journal article: SCHIZOPHRENIA RESEARCH. 2008;102(1-3):146-147

OLFACTORY-VISUAL INTERACTIONS IN EMOTIONAL FACE PROCESSING

Seubert J; Boers F; Mathiak K; Loughead J; Habel U

Funding

We gratefully acknowledge the support of our work by the following research funds: 

Staff and contact

Group leader

All members of the group

News & Press

Episode on taste in podcast Psykologisk forskning

Profile picture for the podcast Psykologisk forskning
Photo: privat

"Food is on our lips – and in our thoughts – almost all the time. But why do we like certain flavors – are such preferences innate, learned, or both? Is the visual system involved when we eat? Janina Seubert answers questions and talks about her research on how smell, taste, and other senses interact when we eat, on the podcast of the Division of Psychology Psykologisk forskning, the episode is available on Spotify and Apple podcasts.

Interview on spicy tastes on SVTs morgonstudion

Photo: N/A

The spicy noodle challenged revisited. Janina Seubert visited SVT:s Morgonstudion for a conversation on why we experience the 'spicy noodles' as so spicy.

Interview on odors with Handelsnytt

handelsnytt
Photo: handelsnytt

In this Handelsnytt article, Janina Seubert answers questions around odors such as why we stop smelling odors after being exposed to them for some time and what her favorite odor is.

Lecture at the Senior University Stockholm 

senior university stockholm
Photo: senior university stockholm

Why does this taste good or bad? Janina Seubert answers this and other questions about the neuroscience of taste in a lecture for the Senior University Stockholm.

Janina Seubert elected as member of the Young Academy of Sweden

Portrait of Janina Seubert and Karolina Kauppi
Janina Seubert, Karolina Kauppi. Photo: Gunilla Sonnebring,Stefan Zimmerman

Janina Seubert, researcher in psychology and PI of the Nutrilab, has been elected as member of The Young Academy of Sweden (Sveriges Unga Akademi) together with Karolina Kauppi, researcher in medical biology. The Young Academy of Sweden was established by the Royal Academy of Sweden and is an independent and interdisciplinary organization that gives young researchers a platform to contribute to research policy debate and communicate research to children and young people.