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Molekylär Farmakologi av GPCR:er – Pawel Kozielewiczs team
Vi är intresserade av att förstå rollen hos understuderade G-proteinkopplade receptorer (GPCR:er) i hälsa och sjukdom. Vi använder biofysiska och beräkningsbaserade metoder för att studera farmakologi, signalering och sjukdomsrelevans hos orphan-GPCR:er, med målet att kunna rikta dem terapeutiskt.
Publikationer
Alla gruppmedlemmars publikationer
- Journal article: BIOPHYSICAL CHEMISTRY. 2026;339:107703Suchomski D; Wesolowski PA; Bojarski KK
- Journal article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2026Andersson L; Wesołowski PA; Jahrstorfer L; De Rosa A; Heger T; Neuman V; Sieradzan AK; Wales DJ; Kozielewicz P
- Preprint: RESEARCH SQUARE. 2026Schulte G; Shekhani R; Scharf M; Kinsolving J; Martiniani G; Resink T; Voss J; Kozielewicz P; Jarnot N; Ragaller F; Schotman N; Ho JY; Peysson F; Tan SM; Pang A; Kumar J; Ljunggren H-G; Bryja V; Tripsianes K; Danev R; Achour A; Sezgin E; Granier S; Sounier R; Tan YZ
- Preprint: BIORXIV. 2026Roggia M; Chianese U; Amendola G; Albanese V; Vetrei C; Ieranò C; D’Alterio C; Di Maro S; Ciardiello F; Morgillo F; Scala S; Altucci L; Preti D; Schulte G; Benedetti R; Kozielewicz P; Cosconati S
- Preprint: BIORXIV. 2026Marciniak A; Kozielewicz P; Mitrovic D; Delemotte L
- Journal article: JOURNAL OF BIOLOGICAL PHYSICS. 2026;52(1):24Wesolowski PA
- Article: NATURE COMMUNICATIONS. 2026;17(1):7020Andersson L; Roggia M; Wangriatisak K; Kozel RS; Brittain HR; Youhanna S; Gil M; Haag M; Lauschke VM; Chemin K; Cosconati S; Kozielewicz P
- Journal article: JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2026;66(10):6159-6180Bojarski KK; Wesolowski PA; Dewan D; Dziadek LJ; Neuman V; Brooks BR; Czub J; Zacharias M; Sieradzan AK; Wales DJ
- Preprint: BIORXIV. 2026Andersson L; Wesolowski P; Jahrstorfer L; De Rosa A; Heger T; Neuman V; Sieradzan A; Wales D; Kozielewicz P
- Journal article: JOURNAL OF CHEMICAL PHYSICS. 2026;164(4):044112Neuman V; Wesolowski PA; Bojarski KK; Dewan D; Schaffler M; Smardz P; Wales DJ
- Preprint: ELSEVIER BV. 2026Bojarski K; Suchomski D; Wesołowski PA
- Preprint: AMERICAN CHEMICAL SOCIETY (ACS). 2025Bojarski K; Wesołowski P; Dewan D; Dziadek Ł; Neuman V; Brooks B; Czub J; Zacharias M; Sieradzan A; Wales D
- Article: BRITISH JOURNAL OF PHARMACOLOGY. 2025;182(Suppl 1):S24-S151Alexander SPH; Davenport AP; Kelly E; Gibb AJ; Mathie AA; Peach CJ; Veale EL; Armstrong JF; Faccenda E; Harding SD; Southan C; Davies JA; Abbracchio MP; Abraham GR; Agoulnik A; Alexander W; Al-hosaini K; Back M; Baker JG; Barnes NM; Bathgate R; Beaulieu J-M; Beck-Sickinger AG; Behrens M; Bennett KA; Bernstein KE; Bettler B; Birdsall NJM; Blaho VA; Bonaventure P; Boulay F; Bousquet C; Brauner-Osborne H; Brown AJ; Burnstock G; Busnelli M; Calo G; Caruso V; Castano JP; Catt KJ; Ceruti S; Chazot P; Chiang N; Chini B; Christopoulos A; Chun J; Cianciulli A; Civelli O; Clapp LH; Couture R; Cox HM; Csaba Z; Dahlgren C; Dautzenberg FM; Dent G; Douglas SD; Dournaud P; Dubocovich ML; Eguchi S; Escher E; Filardo EJ; Fong T; Forsman HF; Fumagalli M; Gainetdinov RR; Garelja ML; de Gasparo M; Gbahou F; Gerard C; Gershengorn M; Glass M; Gloriam DE; Gobeil F; Goodfriend TL; Goudet C; Gratz L; Gregory KJ; Gruber C; Gundlach AL; Hamann J; Hanson J; Hartman DS; Hauger RL; Hay DL; Heinemann A; Heitman L; Herr DR; Hollenberg MD; Holliday ND; Holst B; Horiuchi M; Hoyer D; Hunyady L; Husain A; IJzerman AP; Inagami T; Insel PA; Jacobson KA; Jacobson LH; Jensen RT; Jockers R; Jonnalagadda D; Karnik S; Kaupmann K; Kemp J; Kennedy C; Kihara Y; Kinsolving J; Kitazawa T; Kozielewicz P; Kreienkamp H-J; Kukkonen JP; Laishram L; Langenhan T; Langmead CJ; Larhammar D; Leach K; Lecca D; Lee JD; Leeman SE; Leprince J; Leurs R; Li XX; Liebscher I; Lolait SJ; Lupp A; Macrae R; Maguire JJ; Malfacini D; Manning M; Marangon D; Martemyanov K; Mazella J; McArdle CA; Melmed S; Michel MC; Miller LJ; Mitolo V; Mouillac B; Mueller CE; Murphy PM; Nahon J-L; Neubig RR; Ngo T; Norel X; Nyimanu D; O'Carroll A-M; Offermanns S; Panaro MA; Parmentier M; Perry-Hauser N; Pertwee RG; Pin J-P; Prossnitz ER; Qin HC; Quinn M; Raffaele S; Ramachandran R; Ray M; Reinscheid RK; Buzon AR; Rondard P; Rosenkilde MM; Rovati GE; Ruzza C; Sanger GJ; Scholz N; Schoeneberg T; Schulte G; Schulz S; Segaloff DL; Serhan CN; Shukla AK; Singh KD; Smith CM; Smith NJ; Staeubert C; Stoddart LA; Sugimoto Y; Summers R; Tan VP; Thal DM; Thomas WW; Timmermans PBMWM; Tirupula K; Toll L; Tulipano G; Unal H; Unger T; Valant C; Vanderheyden P; Vaudry D; Vaudry H; Verbalis JG; Vilardaga J-P; Walker CS; Wang JM; Ward DT; Wester H-J; Willars GB; Williams TL; Woodruff TM; Wu H; Yang C; Yao C; Ye RD; Zaidman N
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2025;301(11):110751Gratz L; Turku A; Kozielewicz P; Bowin C-F; Scharf MM; Voss JH; Kinsolving J; Shekhani R; Oliva-Vilarnau N; Koolmeister T; Lauschke VM; Gmeiner P; Schulte G
- Preprint: AMERICAN CHEMICAL SOCIETY (ACS). 2025Neuman V; Wesołowski P; Bojarski K; Dewan D; Schäffler M; Smardz P; Wales D
- Journal article: JOURNAL OF PHYSICAL CHEMISTRY B. 2025;129(39):9953-9964Wesolowski PA; Wales DJ; Bojarski KK
- Journal article: IUPHAR/BPS GUIDE TO PHARMACOLOGY CITE. 2025;2025(3)Arthofer E; Valnohova J; Strakova K; Schulte G; Polonio T; Petersen J; Olofsson J; Lauth M; Kozielewicz P; Kinsolving J; Hot B; Grätz L; Dijksterhuis J; Wright S
- Journal article: EMBO JOURNAL. 2025;44(17):4720-4744Wierbilowicz K; Yang C-S; Almaghasilah A; Wesolowski PA; Pracht P; Dworak NM; Masur J; Wijngaarden S; Filippov DV; Wales DJ; Kelley JB; Ratan A; Paschal BM
- Review: BRITISH JOURNAL OF PHARMACOLOGY. 2025;182(14):3249-3300Morales P; Scharf MM; Bermudez M; Egyed A; Franco R; Hansen OK; Jagerovic N; Jakubik J; Keseru GM; Kiss DJ; Kozielewicz P; Larsen O; Majellaro M; Mallo-Abreu A; Navarro G; Prieto-Diaz R; Rosenkilde MM; Sotelo E; Stark H; Werner T; Wingler LM
- Preprint: BIORXIV. 2025Andersson L; Roggia M; Wangriatisak K; Gil M; Chemin K; Cosconati S; Kozielewicz P
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Medarbetare och kontakt
Gruppledare
- Paweł KozielewiczBiträdande Lektor | Teamledare | Docent
Alla medarbetare i gruppen
- Rhiannon KozelForskningsassistent
- Aditya SoniDoktorand
- Patryk WesolowskiPostdoktor
Besöksadress
Karolinska Institutet, Physiology and Pharmacology, Solnavägen 9, Biomedicum C5, Stockholm, Stockholms län, 17165, Sweden
Postadress
Karolinska Institutet, Physiology and Pharmacology, Tomtebodavägen 16, Biomedicum C5, Stockholm, Stockholms län, 17165, Sweden