Paweł Kozielewicz

Paweł Kozielewicz

Biträdande Lektor | Teamledare | Docent
Besöksadress: Solnavägen 9, Biomedicum, 17165 Solna
Postadress: C3 Fysiologi och farmakologi, C3 FyFa R Molekylär farmakologi av G protein-kopplade receptorer, 171 77 Stockholm
Del av:

Artiklar

  • Article: NATURE COMMUNICATIONS. 2026;17(1):7020
    Andersson L; Roggia M; Wangriatisak K; Kozel RS; Brittain HR; Youhanna S; Gil M; Haag M; Lauschke VM; Chemin K; Cosconati S; Kozielewicz P
  • Article: BRITISH JOURNAL OF PHARMACOLOGY. 2025;182(Suppl 1):S24-S151
    Alexander SPH; Davenport AP; Kelly E; Gibb AJ; Mathie AA; Peach CJ; Veale EL; Armstrong JF; Faccenda E; Harding SD; Southan C; Davies JA; Abbracchio MP; Abraham GR; Agoulnik A; Alexander W; Al-hosaini K; Back M; Baker JG; Barnes NM; Bathgate R; Beaulieu J-M; Beck-Sickinger AG; Behrens M; Bennett KA; Bernstein KE; Bettler B; Birdsall NJM; Blaho VA; Bonaventure P; Boulay F; Bousquet C; Brauner-Osborne H; Brown AJ; Burnstock G; Busnelli M; Calo G; Caruso V; Castano JP; Catt KJ; Ceruti S; Chazot P; Chiang N; Chini B; Christopoulos A; Chun J; Cianciulli A; Civelli O; Clapp LH; Couture R; Cox HM; Csaba Z; Dahlgren C; Dautzenberg FM; Dent G; Douglas SD; Dournaud P; Dubocovich ML; Eguchi S; Escher E; Filardo EJ; Fong T; Forsman HF; Fumagalli M; Gainetdinov RR; Garelja ML; de Gasparo M; Gbahou F; Gerard C; Gershengorn M; Glass M; Gloriam DE; Gobeil F; Goodfriend TL; Goudet C; Gratz L; Gregory KJ; Gruber C; Gundlach AL; Hamann J; Hanson J; Hartman DS; Hauger RL; Hay DL; Heinemann A; Heitman L; Herr DR; Hollenberg MD; Holliday ND; Holst B; Horiuchi M; Hoyer D; Hunyady L; Husain A; IJzerman AP; Inagami T; Insel PA; Jacobson KA; Jacobson LH; Jensen RT; Jockers R; Jonnalagadda D; Karnik S; Kaupmann K; Kemp J; Kennedy C; Kihara Y; Kinsolving J; Kitazawa T; Kozielewicz P; Kreienkamp H-J; Kukkonen JP; Laishram L; Langenhan T; Langmead CJ; Larhammar D; Leach K; Lecca D; Lee JD; Leeman SE; Leprince J; Leurs R; Li XX; Liebscher I; Lolait SJ; Lupp A; Macrae R; Maguire JJ; Malfacini D; Manning M; Marangon D; Martemyanov K; Mazella J; McArdle CA; Melmed S; Michel MC; Miller LJ; Mitolo V; Mouillac B; Mueller CE; Murphy PM; Nahon J-L; Neubig RR; Ngo T; Norel X; Nyimanu D; O'Carroll A-M; Offermanns S; Panaro MA; Parmentier M; Perry-Hauser N; Pertwee RG; Pin J-P; Prossnitz ER; Qin HC; Quinn M; Raffaele S; Ramachandran R; Ray M; Reinscheid RK; Buzon AR; Rondard P; Rosenkilde MM; Rovati GE; Ruzza C; Sanger GJ; Scholz N; Schoeneberg T; Schulte G; Schulz S; Segaloff DL; Serhan CN; Shukla AK; Singh KD; Smith CM; Smith NJ; Staeubert C; Stoddart LA; Sugimoto Y; Summers R; Tan VP; Thal DM; Thomas WW; Timmermans PBMWM; Tirupula K; Toll L; Tulipano G; Unal H; Unger T; Valant C; Vanderheyden P; Vaudry D; Vaudry H; Verbalis JG; Vilardaga J-P; Walker CS; Wang JM; Ward DT; Wester H-J; Willars GB; Williams TL; Woodruff TM; Wu H; Yang C; Yao C; Ye RD; Zaidman N
  • Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2025;301(11):110751
    Gratz L; Turku A; Kozielewicz P; Bowin C-F; Scharf MM; Voss JH; Kinsolving J; Shekhani R; Oliva-Vilarnau N; Koolmeister T; Lauschke VM; Gmeiner P; Schulte G
  • Journal article: IUPHAR/BPS GUIDE TO PHARMACOLOGY CITE. 2025;2025(3)
    Arthofer E; Valnohova J; Strakova K; Schulte G; Polonio T; Petersen J; Olofsson J; Lauth M; Kozielewicz P; Kinsolving J; Hot B; Grätz L; Dijksterhuis J; Wright S
  • Article: MOLECULAR PHARMACOLOGY. 2025;107(4):100026
    Tsang CH; De Rosa A; Kozielewicz P
  • Article: ACS PHARMACOLOGY AND TRANSLATIONAL SCIENCE. 2024;7(12):4000-4009
    Tsang CH; Kozielewicz P
  • Article: BRITISH JOURNAL OF PHARMACOLOGY. 2024;181(20):3819-3835
    Gratz L; Sajkowska-Kozielewicz JJ; Wesslowski J; Kinsolving J; Bridge LJ; Petzold K; Davidson G; Schulte G; Kozielewicz P
  • Article: BIOORGANIC CHEMISTRY. 2024;151:107681
    Espinosa-Bustos C; Bertrand J; Villegas-Menares A; Guerrero S; Di Marcotullio L; Navacci S; Schulte G; Kozielewicz P; Bloch N; Villela V; Paulino M; Kogan MJ; Cantero J; Salas CO
  • Article: SLAS DISCOVERY. 2024;29(6):100174
    Sajkowska JJ; Tsang CH; Kozielewicz P
  • Article: CELL REPORTS. 2024;43(2):113727
    Kinsolving J; Bous J; Kozielewicz P; Kosenina S; Shekhani R; Gratz L; Masuyer G; Wang Y; Stenmark P; Dong M; Schulte G
  • Article: BRITISH JOURNAL OF PHARMACOLOGY. 2023;180(Suppl 2):S23-S144
    Alexander SPH; Christopoulos A; Davenport AP; Kelly E; Mathie AA; Peters JA; Veale EL; Armstrong JF; Faccenda E; Harding SD; Davies JA; Abbracchio MP; Abraham G; Agoulnik A; Alexander W; Al-hosaini K; Back M; Baker JG; Barnes NM; Bathgate R; Beaulieu J-M; Beck-Sickinger AG; Behrens M; Bernstein KE; Bettler B; Birdsall NJM; Blaho V; Boulay F; Bousquet C; Brauner-Osborne H; Burnstock G; Calo G; Castano JP; Catt KJ; Ceruti S; Chazot P; Chiang N; Chini B; Chun J; Cianciulli A; Civelli O; Clapp LH; Couture R; Cox HM; Csaba Z; Dahlgren C; Dent G; Douglas SD; Dournaud P; Eguchi S; Escher E; Filardo EJ; Fong T; Fumagalli M; Gainetdinov RR; Garelja ML; de Gasparo M; Gerard C; Gershengorn M; Gobeil F; Goodfriend TL; Goudet C; Gratz L; Gregory KJ; Gundlach AL; Hamann J; Hanson J; Hauger RL; Hay DL; Heinemann A; Herr D; Hollenberg MD; Holliday ND; Horiuchi M; Hoyer D; Hunyady L; Husain A; Ijzerman AP; Inagami T; Jacobson KA; Jensen RT; Jockers R; Jonnalagadda D; Karnik S; Kaupmann K; Kemp J; Kennedy C; Kihara Y; Kitazawa T; Kozielewicz P; Kreienkamp H-J; Kukkonen JP; Langenhan T; Larhammar D; Leach K; Lecca D; Lee JD; Leeman SE; Leprince J; Li XX; Lolait SJ; Lupp A; Macrae R; Maguire J; Malfacini D; Mazella J; McArdle CA; Melmed S; Michel MC; Miller LJ; Mitolo V; Mouillac B; Mueller CE; Murphy PM; Nahon J-L; Ngo T; Norel X; Nyimanu D; O'Carroll A-M; Offermanns S; Panaro MA; Parmentier M; Pertwee RG; Pin J-P; Prossnitz ER; Quinn M; Ramachandran R; Ray M; Reinscheid RK; Rondard P; Rovati GE; Ruzza C; Sanger GJ; Schoeneberg T; Schulte G; Schulz S; Segaloff DL; Serhan CN; Singh KD; Smith CM; Stoddart LA; Sugimoto Y; Summers R; Tan VP; Thal D; Thomas WW; Timmermans PBMWM; Tirupula K; Toll L; Tulipano G; Unal H; Unger T; Valant C; Vanderheyden P; Vaudry D; Vaudry H; Vilardaga J-P; Walker CS; Wang JM; Ward DT; Wester H-J; Willars GB; Williams TL; Woodruff TM; Yao C; Ye RD
  • Article: NATURE COMMUNICATIONS. 2023;14(1):4573
    Gratz L; Kowalski-Jahn M; Scharf MM; Kozielewicz P; Jahn M; Bous J; Lambert NA; Gloriam DE; Schulte G
  • Journal article: IUPHAR/BPS GUIDE TO PHARMACOLOGY CITE. 2023;2023(1)
    Arthofer E; Dijksterhuis J; Grätz L; Hot B; Kozielewicz P; Lauth M; Olofsson J; Petersen J; Polonio T; Schulte G; Strakova K; Valnohova J; Wright S
  • Article: SCIENCE SIGNALING. 2023;16(779):eabo4974
    Bowin C-F; Kozielewicz P; Gratz L; Kowalski-Jahn M; Schihada H; Schulte G
  • Article: METHODS IN MOLECULAR BIOLOGY. 2022;2374:195-204
    Kozielewicz P; Schulte G
  • Article: BRITISH JOURNAL OF PHARMACOLOGY. 2021;178:S27-S156
    Alexander SPH; Christopoulos A; Davenport AP; Kelly E; Mathie A; Peters JA; Veale EL; Armstrong JF; Faccenda E; Harding SD; Pawson AJ; Southan C; Davies JA; Abbracchio MP; Alexander W; Al-hosaini K; Baeck M; Barnes NM; Bathgate R; Beaulieu J-M; Bernstein KE; Bettler B; Birdsall NJM; Blaho V; Boulay F; Bousquet C; Braeuner-Osborne H; Burnstock G; Calo G; Castano JP; Catt K; Ceruti S; Chazot P; Chiang N; Chini B; Chun J; Cianciulli A; Civelli O; Clapp LH; Couture R; Csaba Z; Dahlgren C; Dent G; Singh KD; Douglas SD; Dournaud P; Eguchi S; Escher E; Filardo EJ; Fong T; Fumagalli M; Gainetdinov RR; de Gasparo M; Gerard C; Gershengorn M; Gobeil F; Goodfriend TL; Goudet C; Gregory KJ; Gundlach AL; Hamann J; Hanson J; Hauger RL; Hay DL; Heinemann A; Hollenberg MD; Holliday ND; Horiuchi M; Hoyer D; Hunyady L; Husain A; IJzerman AP; Inagami T; Jacobson KA; Jensen RT; Jockers R; Jonnalagadda D; Karnik S; Kaupmann K; Kemp J; Kennedy C; Kihara Y; Kitazawa T; Kozielewicz P; Kreienkamp H-J; Kukkonen JP; Langenhan T; Leach K; Lecca D; Lee JD; Leeman SE; Leprince J; Li XX; Williams TL; Lolait SJ; Lupp A; Macrae R; Maguire J; Mazella J; McArdle CA; Melmed S; Michel MC; Miller LJ; Mitolo V; Mouillac B; Mueller CE; Murphy P; Nahon J-L; Ngo T; Norel X; Nyimanu D; Ocarroll A-M; Offermanns S; Panaro MA; Parmentier M; Pertwee RG; Pin J-P; Prossnitz ER; Quinn M; Ramachandran R; Ray M; Reinscheid RK; Rondard P; Rovati GE; Ruzza C; Sanger GJ; Schoeneberg T; Schulte G; Schulz S; Segaloff DL; Serhan CN; Stoddart LA; Sugimoto Y; Summers R; Tan VP; Thal D; Thomas WW; Timmermans PMWM; Tirupula K; Tulipano G; Unal H; Unger T; Valant C; Vanderheyden P; Vaudry D; Vaudry H; Vilardaga J-P; Walker CS; Wang JM; Ward DT; Wester H-J; Willars GB; Woodruff TM; Yao C; Ye RD
  • Journal article: IUPHAR/BPS GUIDE TO PHARMACOLOGY CITE. 2021;2021(3)
    Arthofer E; Dijksterhuis J; Hot B; Kozielewicz P; Lauth M; Olofsson J; Petersen J; Polonio T; Schulte G; Strakova K; Valnohova J; Wright S
  • Article: NATURE COMMUNICATIONS. 2021;12(1):3919
    Turku A; Schihada H; Kozielewicz P; Bowin C-F; Schulte G
  • Article: ACS PHARMACOLOGY AND TRANSLATIONAL SCIENCE. 2021;4(3):1235-1245
    Kozielewicz P; Shekhani R; Moser S; Bowin C-F; Wesslowski J; Davidson G; Schulte G
  • Article: HANDBOOK OF EXPERIMENTAL PHARMACOLOGY. 2021;269:101-115
    Kozielewicz P; Schihada H; Schulte G
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Alla övriga publikationer

Forskningsbidrag

  • Proof-of-concept studies to propose an orphan G protein-coupled receptor GPR61 as a novel target in metabolic disorders
    SRP Diabetes Blue Sky Grant 2025
    1 maj 2025 - 31 december 2026
  • Understanding the role of orphan GPCR GPR61 in obesity
    Karolinska Institutet Research Foundation
    25 november 2024 - 24 november 2026
  • Targeting G protein-coupled receptors in cancers
    Karolinska Institutet
    10 oktober 2024 - 9 oktober 2027
  • GPR34, GPR65 och GPR183 som terapeutiska mĺl i blodcancer
    Jeanssons Stiftelser
    13 december 2023 - 12 december 2024
  • Swedish Research Council
    1 januari 2023 - 31 december 2026
    G-protein-coupled receptors (GPCRs) constitute 30% of all drug targets and are often overexpressed and mutated in cancer, including haematological disorders. There is an immediate need for better treatment for patients suffering from peripheral blood cancers. For example, 41% of people diagnosed with Non-Hodgkin Lymphoma are predicted to survive less than 10 years. In the proposed project, I will focus on the GPCRs GPR34, GPR65 and GPR183. I have selected these three receptors based on the current literature and my preliminary data which support the hypothesis that they can be potential therapeutic targets. To test my assumptions, I will develop and employ novel biophysical BRET-based tools to assess ligand-induced conformational changes in GPR34/65/183 together with receptor-mediated G protein activation and recruitment of intracellular transducer proteins. These assays will be used to test the activity of small ligands predicted from large in silico screenings. Subsequently, I will analyse if up- or down-regulation, and mutations in GPR34/65/183 influence the functions of in vitro cultured cells of haematological origin and healthy B- and T-cells. My research will provide the first complexed insight into the role of these GPCRs in malignant and normal blood cells, and will aid the discovery of novel compounds with exciting prospects as anti-cancer drugs

Anställningar

  • Biträdande Lektor, Fysiologi och farmakologi, Karolinska Institutet, 2023-2029

Examina och utbildning

  • Docent, Farmakologi och toxikologi, Karolinska Institutet, 2025
  • Habilitation in Medical Sciences, Medical University of Lublin, 2022
  • PhD in Clinical and Experimental Medicine, University of Birmingham, 2017
  • Master's of Pharmacy, Medical University of Warsaw, 2013

Uppdrag

  • Biträdande PD för mastersprogrammet, The Master's Programme in Translational Physiology and Pharmacology, Department of Physiology and Pharmacology, Karolinska Institutet, 2025-
  • Teamledare, Molecular Pharmacology of GPCRs, Department of Physiology and Pharmacology, Karolinska Institutet, 2024-

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