Paweł Kozielewicz
Biträdande Lektor | Teamledare
E-postadress: pawel.kozielewicz@ki.se
Besöksadress: Solnavägen 9, Biomedicum, 17165 Solna
Postadress: C3 Fysiologi och farmakologi, C3 FyFa Receptorbiologi Molekylär farmakologi av G protein-kopplade receptorer, 171 77 Stockholm
Del av:
- Institutionen för fysiologi och farmakologi
- Receptorbiologi och signalering – Schulte Lab
- G-protein interaktioner i WNT-Frizzled-vägarna – Jon Voss team
Artiklar
- Article: MOLECULAR PHARMACOLOGY. 2025;107(4):100026Tsang CH; De Rosa A; Kozielewicz P
- Article: ACS PHARMACOLOGY AND TRANSLATIONAL SCIENCE. 2024;7(12):4000-4009Tsang CH; Kozielewicz P
- Article: BRITISH JOURNAL OF PHARMACOLOGY. 2024;181(20):3819-3835Gratz L; Sajkowska-Kozielewicz JJ; Wesslowski J; Kinsolving J; Bridge LJ; Petzold K; Davidson G; Schulte G; Kozielewicz P
- Article: BIOORGANIC CHEMISTRY. 2024;151:107681Espinosa-Bustos C; Bertrand J; Villegas-Menares A; Guerrero S; Di Marcotullio L; Navacci S; Schulte G; Kozielewicz P; Bloch N; Villela V; Paulino M; Kogan MJ; Cantero J; Salas CO
- Article: SLAS DISCOVERY. 2024;29(6):100174Sajkowska JJ; Tsang CH; Kozielewicz P
- Article: CELL REPORTS. 2024;43(2):113727Kinsolving J; Bous J; Kozielewicz P; Kosenina S; Shekhani R; Gratz L; Masuyer G; Wang Y; Stenmark P; Dong M; Schulte G
- Article: BRITISH JOURNAL OF PHARMACOLOGY. 2023;180:S23-S144Alexander SPH; Christopoulos A; Davenport AP; Kelly E; Mathie AA; Peters JA; Veale EL; Armstrong JF; Faccenda E; Harding SD; Davies JA; Abbracchio MP; Abraham G; Agoulnik A; Alexander W; Al-hosaini K; Back M; Baker JG; Barnes NM; Bathgate R; Beaulieu J-M; Beck-Sickinger AG; Behrens M; Bernstein KE; Bettler B; Birdsall NJM; Blaho V; Boulay F; Bousquet C; Brauner-Osborne H; Burnstock G; Calo G; Castano JP; Catt KJ; Ceruti S; Chazot P; Chiang N; Chini B; Chun J; Cianciulli A; Civelli O; Clapp LH; Couture R; Cox HM; Csaba Z; Dahlgren C; Dent G; Douglas SD; Dournaud P; Eguchi S; Escher E; Filardo EJ; Fong T; Fumagalli M; Gainetdinov RR; Garelja ML; de Gasparo M; Gerard C; Gershengorn M; Gobeil F; Goodfriend TL; Goudet C; Gratz L; Gregory KJ; Gundlach AL; Hamann J; Hanson J; Hauger RL; Hay DL; Heinemann A; Herr D; Hollenberg MD; Holliday ND; Horiuchi M; Hoyer D; Hunyady L; Husain A; Ijzerman AP; Inagami T; Jacobson KA; Jensen RT; Jockers R; Jonnalagadda D; Karnik S; Kaupmann K; Kemp J; Kennedy C; Kihara Y; Kitazawa T; Kozielewicz P; Kreienkamp H-J; Kukkonen JP; Langenhan T; Larhammar D; Leach K; Lecca D; Lee JD; Leeman SE; Leprince J; Li XX; Lolait SJ; Lupp A; Macrae R; Maguire J; Malfacini D; Mazella J; McArdle CA; Melmed S; Michel MC; Miller LJ; Mitolo V; Mouillac B; Mueller CE; Murphy PM; Nahon J-L; Ngo T; Norel X; Nyimanu D; O'Carroll A-M; Offermanns S; Panaro MA; Parmentier M; Pertwee RG; Pin J-P; Prossnitz ER; Quinn M; Ramachandran R; Ray M; Reinscheid RK; Rondard P; Rovati GE; Ruzza C; Sanger GJ; Schoeneberg T; Schulte G; Schulz S; Segaloff DL; Serhan CN; Singh KD; Smith CM; Stoddart LA; Sugimoto Y; Summers R; Tan VP; Thal D; Thomas WW; Timmermans PBMWM; Tirupula K; Toll L; Tulipano G; Unal H; Unger T; Valant C; Vanderheyden P; Vaudry D; Vaudry H; Vilardaga J-P; Walker CS; Wang JM; Ward DT; Wester H-J; Willars GB; Williams TL; Woodruff TM; Yao C; Ye RD
- Article: NATURE COMMUNICATIONS. 2023;14(1):4573Gratz L; Kowalski-Jahn M; Scharf MM; Kozielewicz P; Jahn M; Bous J; Lambert NA; Gloriam DE; Schulte G
- Journal article: IUPHAR/BPS GUIDE TO PHARMACOLOGY CITE. 2023;2023(1)Arthofer E; Dijksterhuis J; Grätz L; Hot B; Kozielewicz P; Lauth M; Olofsson J; Petersen J; Polonio T; Schulte G; Strakova K; Valnohova J; Wright S
- Article: SCIENCE SIGNALING. 2023;16(779):eabo4974Bowin C-F; Kozielewicz P; Gratz L; Kowalski-Jahn M; Schihada H; Schulte G
- Article: METHODS IN MOLECULAR BIOLOGY. 2022;2374:195-204Kozielewicz P; Schulte G
- Journal article: CELL RESEARCH. 2021;31(12):1311-1314Xu L; Chen B; Schihada H; Wright SC; Turku A; Wu Y; Han G-W; Kowalski-Jahn M; Kozielewicz P; Bowin C-F; Zhang X; Li C; Bouvier M; Schulte G; Xu F
- Article: BRITISH JOURNAL OF PHARMACOLOGY. 2021;178:S27-S156Alexander SPH; Christopoulos A; Davenport AP; Kelly E; Mathie A; Peters JA; Veale EL; Armstrong JF; Faccenda E; Harding SD; Pawson AJ; Southan C; Davies JA; Abbracchio MP; Alexander W; Al-hosaini K; Baeck M; Barnes NM; Bathgate R; Beaulieu J-M; Bernstein KE; Bettler B; Birdsall NJM; Blaho V; Boulay F; Bousquet C; Braeuner-Osborne H; Burnstock G; Calo G; Castano JP; Catt K; Ceruti S; Chazot P; Chiang N; Chini B; Chun J; Cianciulli A; Civelli O; Clapp LH; Couture R; Csaba Z; Dahlgren C; Dent G; Singh KD; Douglas SD; Dournaud P; Eguchi S; Escher E; Filardo EJ; Fong T; Fumagalli M; Gainetdinov RR; de Gasparo M; Gerard C; Gershengorn M; Gobeil F; Goodfriend TL; Goudet C; Gregory KJ; Gundlach AL; Hamann J; Hanson J; Hauger RL; Hay DL; Heinemann A; Hollenberg MD; Holliday ND; Horiuchi M; Hoyer D; Hunyady L; Husain A; IJzerman AP; Inagami T; Jacobson KA; Jensen RT; Jockers R; Jonnalagadda D; Karnik S; Kaupmann K; Kemp J; Kennedy C; Kihara Y; Kitazawa T; Kozielewicz P; Kreienkamp H-J; Kukkonen JP; Langenhan T; Leach K; Lecca D; Lee JD; Leeman SE; Leprince J; Li XX; Williams TL; Lolait SJ; Lupp A; Macrae R; Maguire J; Mazella J; McArdle CA; Melmed S; Michel MC; Miller LJ; Mitolo V; Mouillac B; Mueller CE; Murphy P; Nahon J-L; Ngo T; Norel X; Nyimanu D; Ocarroll A-M; Offermanns S; Panaro MA; Parmentier M; Pertwee RG; Pin J-P; Prossnitz ER; Quinn M; Ramachandran R; Ray M; Reinscheid RK; Rondard P; Rovati GE; Ruzza C; Sanger GJ; Schoeneberg T; Schulte G; Schulz S; Segaloff DL; Serhan CN; Stoddart LA; Sugimoto Y; Summers R; Tan VP; Thal D; Thomas WW; Timmermans PMWM; Tirupula K; Tulipano G; Unal H; Unger T; Valant C; Vanderheyden P; Vaudry D; Vaudry H; Vilardaga J-P; Walker CS; Wang JM; Ward DT; Wester H-J; Willars GB; Woodruff TM; Yao C; Ye RD
- Journal article: IUPHAR/BPS GUIDE TO PHARMACOLOGY CITE. 2021;2021(3)Arthofer E; Dijksterhuis J; Hot B; Kozielewicz P; Lauth M; Olofsson J; Petersen J; Polonio T; Schulte G; Strakova K; Valnohova J; Wright S
- Article: NATURE COMMUNICATIONS. 2021;12(1):3919Turku A; Schihada H; Kozielewicz P; Bowin C-F; Schulte G
- Article: ACS PHARMACOLOGY AND TRANSLATIONAL SCIENCE. 2021;4(3):1235-1245Kozielewicz P; Shekhani R; Moser S; Bowin C-F; Wesslowski J; Davidson G; Schulte G
- Article: HANDBOOK OF EXPERIMENTAL PHARMACOLOGY. 2021;269:101-115Kozielewicz P; Schihada H; Schulte G
- Article: MOLECULES. 2020;26(1):E143-143Sajkowska-Kozielewicz JJ; Kozielewicz P; Makarova K; Stocki M; Barnes NM; Paradowska K
- Journal article: FARMACJA POLSKA. 2020;76(10):592-599Kwas K; Mostowy M; Kozielewicz P; Sajkowska-Kozielewicz J
- Article: EMBO REPORTS. 2020;21(8):e48882Kuzniewska B; Cysewski D; Wasilewski M; Sakowska P; Milek J; Kulinski TM; Winiarski M; Kozielewicz P; Knapska E; Dadlez M; Chacinska A; Dziembowski A; Dziembowska M
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2020;295(26):8759-8774Wesslowski J; Kozielewicz P; Wang X; Cui H; Schihada H; Kranz D; Karuna PM; Levkin P; Gross JC; Boutros M; Schulte G; Davidson G
- Article: NATURE COMMUNICATIONS. 2020;11(1):414Kozielewicz P; Turku A; Bowin C-F; Petersen J; Valnohova J; Canizal MCA; Ono Y; Inoue A; Hoffmann C; Schulte G
- Article: MOLECULAR PHARMACOLOGY. 2020;97(1):23-34Kozielewicz P; Bowin C-F; Turku A; Schulte G
- Article: BRITISH JOURNAL OF PHARMACOLOGY. 2019;176(Suppl 1):S21-S141Alexander SPH; Christopoulos A; Davenport AP; Kelly E; Mathie A; Peters JA; Veale EL; Armstrong JF; Faccenda E; Harding SD; Pawson AJ; Sharman JL; Southan C; Davies JA; Arumugam TV; Bennett A; Sjogren B; Sobey C; Wong SS; Abbracchio MP; Alexander W; Al-hosaini K; Back M; Beaulieu J-M; Bernstein KE; Bettler B; Birdsall NJM; Blaho V; Bousquet C; Brauner-Osborne H; Burnstock G; Calo G; Castano JP; Catt KJ; Ceruti S; Chazot P; Chiang N; Chun J; Cianciulli A; Clapp LH; Couture R; Csaba Z; Dent G; Singh KD; Douglas SD; Dournaud P; Eguchi S; Escher E; Filardo E; Fong TM; Fumagalli M; Gainetdinov RR; de Gasparo M; Gershengorn M; Gobeil F; Goodfriend TL; Goudet C; Gregory KJ; Gundlach AL; Hamann J; Hanson J; Hauger RL; Hay D; Heinemann A; Hollenberg MD; Holliday ND; Horiuchi M; Hoyer D; Hunyady L; Husain A; Ijzerman AP; Inagami T; Jacobson KA; Jensen RT; Jockers R; Jonnalagadda D; Karnik S; Kaupmann K; Kemp J; Kennedy C; Kihara Y; Kozielewicz P; Kreienkamp H-J; Kukkonen JP; Langenhan T; Leach K; Lecca D; Lee JD; Leeman SE; Leprince J; Lolait SJ; Lupp A; Macrae R; Maguire J; Mazella J; McArdle CA; Melmed S; Michel MC; Miller L; Mitolo V; Mouillac B; Murphy PM; Nahon J-L; Norel X; Nyimanu D; O'Carroll A-M; Offermanns S; Panaro MA; Pertwee RG; Pin J-P; Prossnitz E; Ramachandran R; Reinscheid RK; Rondard P; Rovati GE; Ruzza C; Sanger G; Schoeneberg T; Schulte G; Schulz S; Segaloff DL; Serhan CN; Stoddart LA; Sugimoto Y; Summers R; Tan V; Thomas W; Timmermans PBMWM; Tirupula K; Tulipano G; Unal H; Unger T; Vanderheyden P; Vaudry D; Vaudry H; Vilardaga J-P; Walker CS; Ward DT; Wester H-J; Willars GB; Williams TL; Woodruff TM; Yao C; Aldrich RW; Becirovic E; Biel M; Catterall WA; Conner AC; Davies P; Delling M; Di Virgilio F; Falzoni S; George C; Goldstein SAN; Grissmer S; Ha K; Hammelmann V; Hanukoglu I; Jarvis M; Jensen AA; Kaczmarek LK; Kellenberger S; Kennedy C; King B; Lynch JW; Perez-Reyes E; Plant LD; Rash LD; Ren D; Sivilotti LG; Smart TG; Snutch TP; Tian J; Van den Eynde C; Vriens J; Wei AD; Winn BT; Wulff H; Xu H; Yue L; Zhang X; Zhu M; Coons L; Fuller P; Korach KS; Young M; Bryant C; Farndale RW; Hobbs A; Jarvis GE; MacEwan D; Monie TP; Waldman S; Beuve A; Boison D; Brouckaert P; Burnett JC; Burns K; Dessauer C; Friebe A; Garthwaite J; Gertsch J; Helsby N; Izzo AA; Koesling D; Kuhn M; Ostrom R; Papapetropoulos A; Potter LR; Pyne NJ; Pyne S; Russwurm M; Schmidt HHHW; Seifert R; Stasch J-P; Szabo C; van der Stelt M; van der Vliet A; Watts V; Anderson CMH; Broer S; Dawson P; Hagenbuch B; Hammond JR; Hancox J; Inui K-I; Kanai Y; Kemp S; Thwaites DT; Verri T
- Journal article: IUPHAR/BPS GUIDE TO PHARMACOLOGY CITE. 2019;2019(4)Arthofer E; Dijksterhuis J; Hot B; Kozielewicz PL; Lauth M; Olofsson J; Petersen J; Polonio T; Schulte G; Strakova K; Valnohova J; Wright S
- Journal article: FARMACJA POLSKA. 2019;75(8):451-456Kozielewicz P; Owczarek K; Sajkowska-Kozielewicz JJ
- Journal article: LIFE SCIENCES. 2019;225:132Kozielewicz P
- Article: NATURE COMMUNICATIONS. 2019;10(1):667Wright SC; Kozielewicz P; Kowalski-Jahn M; Petersen J; Bowin C-F; Slodkowicz G; Marti-Solano M; Rodriguez D; Hot B; Okashah N; Strakova K; Valnohova J; Babu MM; Lambert NA; Carlsson J; Schulte G
- Article: PHARMACOLOGY. 2019;104(5-6):377-382Kozielewicz P; Grafton G; Sajkowska-Kozielewicz JJ; Barnes NM
- Article: CHEMISTRYSELECT. 2018;3(33):9743-9752Tzeli D; Kozielewicz P; Zloh M; Antonow D; Tsoungas PG; Petsalakis ID
- Article: FEBS OPEN BIO. 2017;7(12):1982-1993Kozielewicz P; Alomar H; Yusof S; Grafton G; Cooper AJ; Curnow SJ; Ironside JW; Pall H; Barnes NM
- Article: STRUCTURAL CHEMISTRY. 2017;28(4):925-943Tzeli D; Tsoungas PG; Petsalakis ID; Kozielewicz P
- Article: CHEMISTRYSELECT. 2016;1(10):2426-2438Tzeli D; Kozielewicz P; Zervou M; Potamitis C; Kokkotou K; Rak B; Petrou A; Tsolaki E; Gavalas A; Geronikaki A; Petsalakis ID; Tsoungas PG
- Article: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2016;2016:2573580Sajkowska-Kozielewicz JJ; Kozielewicz P; Barnes NM; Wawer I; Paradowska K
- Article: TETRAHEDRON. 2015;71(2):359-369Tzeli D; Tsoungas PG; Petsalakis ID; Kozielewicz P; Zloh M
- Article: STRUCTURAL CHEMISTRY. 2014;25(6):1837-1846Kozielewicz P; Tzeli D; Tsoungas PG; Zloh M
- Article: STRUCTURAL CHEMISTRY. 2014;25(6):1711-1723Kozielewicz P; Tsoungas PG; Tzeli D; Petsalakis ID; Zloh M
- Article: MONATSHEFTE FUR CHEMIE. 2014;145(7):1201-1211Kozielewicz P; Paradowska K; Eric S; Wawer I; Zloh M
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Alla övriga publikationer
- Review: BRITISH JOURNAL OF PHARMACOLOGY. 2025;182(14):3249-3300Morales P; Scharf MM; Bermudez M; Egyed A; Franco R; Hansen OK; Jagerovic N; Jakubik J; Keseru GM; Kiss DJ; Kozielewicz P; Larsen O; Majellaro M; Mallo-Abreu A; Navarro G; Prieto-Diaz R; Rosenkilde MM; Sotelo E; Stark H; Werner T; Wingler LM
- Preprint: BIORXIV. 2025Andersson L; Roggia M; Wangriatisak K; Gil M; Chemin K; Cosconati S; Kozielewicz P
- Preprint: MEDRXIV. 2024Tsang CH; Rosa AD; Kozielewicz P
- Review: TRENDS IN PHARMACOLOGICAL SCIENCES. 2024;45(5):419-429Schulte G; Scharf MM; Bous J; Voss JH; Gratz L; Kozielewicz P
- Preprint: RESEARCH SQUARE. 2024Schulte G; Grätz L; Turku A; Kozielewicz P; Bowin C-F; Scharf M; Voss J; Kinsolving J; Shekhani R; Oliva-Vilarnau N; Koolmeister T; Körber M; Lauschke V; Löber S; Gmeiner P
- Conference publication: BRITISH JOURNAL OF PHARMACOLOGY. 2023;180(4):479-480Kozielewicz P; Gratz L; Sajkowska-Kozielewicz J; Moser S; Davidson G; Schulte G
- Preprint: BIORXIV. 2022Bowin C-F; Kozielewicz P; Grätz L; Kowalski-Jahn M; Schihada H; Schulte G
- Preprint: BIORXIV. 2022Grätz L; Sajkowska-Kozielewicz J; Wesslowski J; Petzold K; Davidson G; Schulte G; Kozielewicz P
- Review: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2020;126:17-24Schulte G; Kozielewicz P
- Review: MOLECULAR PHARMACOLOGY. 2020;97(2):62-71Kozielewicz P; Turku A; Schulte G
- Preprint: BIORXIV. 2019Kuzniewska B; Cysewski D; Wasilewski M; Sakowska P; Milek J; Kulinski TM; Kozielewicz P; Dadlez M; Chacinska A; Dziembowski A; Dziembowska M
- Preprint: BIORXIV. 2019Kozielewicz P; Bowin C-F; Schulte G
- Conference publication: FEBS OPEN BIO. 2019;9:28-29Kuzniewska B; Cysewski D; Sakowska P; Milek J; Wasilewski M; Winiarski M; Kulinski TM; Kozielewicz P; Knapska E; Chacinska A; Dziembowski A; Dziembowska M
- Meeting abstract: PLANTA MEDICA. 2016;82:s1-s381Sajkowska-Kozielewicz JJ; Kozielewicz P; Makarova K; Wawer I; Paradowska K
- Meeting abstract: PLANTA MEDICA. 2016;82:s1-s381Sajkowska-Kozielewicz JJ; Kozielewicz P; Barnes NM; Wawer I; Paradowska K
- Published conference paper: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2016;164:98-105Kozielewicz P; Grafton G; Kutner A; Curnow SJ; Gordon J; Barnes NM
Forskningsbidrag
- Proof-of-concept studies to propose an orphan G protein-coupled receptor GPR61 as a novel target in metabolic disordersSRP Diabetes Blue Sky Grant 20251 May 2025 - 31 December 2026
- Understanding the role of orphan GPCR GPR61 in obesityKarolinska Institutet Research Foundation25 November 2024 - 24 November 2026
- Targeting G protein-coupled receptors in cancersKarolinska Institutet10 October 2024 - 9 October 2027
- GPR34, GPR65 och GPR183 som terapeutiska mĺl i blodcancerJeanssons Stiftelser13 December 2023 - 12 December 2024
- Swedish Research Council1 January 2023 - 31 December 2026G-protein-coupled receptors (GPCRs) constitute 30% of all drug targets and are often overexpressed and mutated in cancer, including haematological disorders. There is an immediate need for better treatment for patients suffering from peripheral blood cancers. For example, 41% of people diagnosed with Non-Hodgkin Lymphoma are predicted to survive less than 10 years. In the proposed project, I will focus on the GPCRs GPR34, GPR65 and GPR183. I have selected these three receptors based on the current literature and my preliminary data which support the hypothesis that they can be potential therapeutic targets. To test my assumptions, I will develop and employ novel biophysical BRET-based tools to assess ligand-induced conformational changes in GPR34/65/183 together with receptor-mediated G protein activation and recruitment of intracellular transducer proteins. These assays will be used to test the activity of small ligands predicted from large in silico screenings. Subsequently, I will analyse if up- or down-regulation, and mutations in GPR34/65/183 influence the functions of in vitro cultured cells of haematological origin and healthy B- and T-cells. My research will provide the first complexed insight into the role of these GPCRs in malignant and normal blood cells, and will aid the discovery of novel compounds with exciting prospects as anti-cancer drugs
Anställningar
- Biträdande Lektor, Fysiologi och farmakologi, Karolinska Institutet, 2023-2029
Examina och utbildning
- Habilitation in Medical Sciences, Medical University of Lublin, 2022
- PhD in Clinical and Experimental Medicine, University of Birmingham, 2017
- Master's of Pharmacy, Medical University of Warsaw, 2013
Uppdrag
- Biträdande PD för mastersprogrammet, The Global Master's Programme in Translational Physiology and Pharmacology, Department of Physiology and Pharmacology, Karolinska Institutet, 2025-
- Teamledare, Molecular Pharmacology of GPCRs, Department of Physiology and Pharmacology, Karolinska Institutet, 2024-