ERC-finansiering vid KI
Europeiska forskningsrådet (ERC) stödjer spetsforskning, mång- och tvärvetenskapliga projekt och banbrytande idéer i nya och framväxande områden. ERC:s uppdrag är att främja forskardriven forskning av högsta kvalitet inom alla vetenskapliga områden genom omfattande och långsiktig finansiering.
ERC Synergy
Syftet med programmet är att föra samman framstående forskare inom närliggande expertområden som kan arbeta tvärvetenskapligt med nyfikenhetsdriven forskning i projekt med potentialen att förändra forskningslandskapet.
2020
András Simon – SALAMANDRA; Avkoda organisationen och regenerationen av motoriska neuronala nätverk i tetrapoder genom att integrera genomik, systemneurovetenskap, numerisk modellering och biorobotik
Samarbete med Auke Ijspeert vid École polytechnique fédérale de Lausanne i Schweiz och Dimitri Ryczko vid Université de Sherbrooke i Kanada.
2019
Mikael Rydén – Lipiddropphypertrofi: kopplingen mellan adipcytdysfunktion och kardiometabola sjukdomar
Samarbete med Bruno Antonny vid CNRS i Frankrike och Dominique Langin (huvudansvarig) vid Université Paul Sabatier i Frankrike.
Igor Adameyko och Susanne Schlisio – Döda eller differentiera: användning av cell-till-cellinteraktioner för att utveckla nya cancerbehandlingar
Igor Adameyko (huvudansvarig) är även verksam vid MedUni Vienna i Österrike. Projektet är ett samarbete med Peter Kharchenko vid Harvard Medical School i USA och Olivier Delattre vid Institut Curie i Frankrike.
ERC Advanced Grant
ERC Advanced Grant (AdG) riktar sig till redan etablerade forskare i världsklass med betydande forskningsinsatser under de senaste 10 åren och omfattar upp till 2,5 miljoner Euro under fem års tid. Vid KI har följande forskare erhållit ERC AdG:
2019
- Ernest Arenas – PreciseCellPD; A precision cell-replacement strategy for Parkinson's Disease
2018
- Per-Olof Berggren – A regenerative medicine approach in diabetes
2017
- Henrik Ehrsson – The Unity of the Bodily Self (SELF-UNITY)
- Gunilla Karlsson Hedestam – Defining human adaptive immune gene diversity and its impact on disease (IMMUNEDIVERSITY)
2016
- Kenneth R. Chien – 5D Heart Patch; A Functional, Mature In vivo Human Ventricular Muscle Patch for Cardiomyopathy.
- Patrik Ernfors (andra anslaget) – PainCells; Decomposition of pain into celltypes.
- Magnus Ingelman-Sundberg – HEPASPHER; Mimicking liver disease and regeneration in vitro for drug development and liver transplantation.
- Nils-Göran Larsson (andra anslaget) – mtDNA-CURE; Treating mitochondrial disease caused by pathogenic mtDNA mutations
2015
- Jonas Frisén (för andra gången) – Exploration and promotion of neurogenesis in the adult brain
- Thomas Helleday (för andra gången) – Targeting oxidative repair proteins for treatment of cancer and inflammation
- Ole Kiehn (för andra gången) – Functional deciphering of the integrated brainstem connectome that selects locomotor behavior
- Klas Wiman – Restoration of tumor suppressor function by induction of translational read-through of premature termination codons; a strategy for improved cancer therapy
2013
- Per-Olof Berggren – An in vivo imaging approach to understand pancreatic beta-cell signal-transduction
- Carlos Ibanez (för andra gången) – Understanding death-receptor signaling and physiology in the nervous system
2012
- Christer Betsholtz – Mechanisms of regulation of the blood-brain barrier
- Lars Olson – Plasticity and formation of lasting memories in health and disease
2010
- Jonas Frisén – Neurogenesis in the adult human brain
- Ole Kiehn – Linking glutamatergic spinal cord and brainstem neuronal circuits to the control of locomotor behavior
- Thomas Helleday – GEnetic NEtworks as a tool for anti CAncer Drug Development
2009
- Lars Klareskog – Genes, environment and immunity in the pathogenesis of rheumatoid arthritis
- Yihai Cao – New mechanisms of angiogenesis modulators in switching between white and brown
2008
- Patrik Ernfors – Identification of new mechanism of stem cell self-renewal
- Carlos Ibanez – Metabolic control by the TGF-x superfamilt receptor ALK7
- Jussi Taipale – Dissecting the transcriptional mechanisms controlling growth during normal development and cancer
- Juleen Zierath – Discovery of type 2 diabetes targets
ERC Consolidator Grant
ERC Consolidator Grant riktar sig till de som nyligen startat en forskargrupp och vill stärka sin roll som forskningsledare, och omfattar upp till 2 miljoner Euro. Första utlysningen skedde 2013. Vid KI har följande forskare erhållit ERC Consolidator Grant:
2019
Camilla Svensson – Autoantibodies and chronic pain - Unraveling new mechanisms contributing to pain in rheumatic disease
Myriam Aouadi – Revealing the contribution of liver macrophage populations to NASH in insulin resistance
2018
Jens Hjerling Leffler – Brain cell type-specific interactions and schizophrenia
Anna Rising – Novel approaches to the generation of artificial spider-silk super fibers
Maja Jagodic – Epi4MS – targeting the epigenome for a better understanding of disease pathogenesis and novel therapeutic strategies in Multiple Sclerosis
2017
- Olov Andersson – In vivo drug discovery for cellular reprogramming to β-cells; towards a future regenerative therapy for diabetes (Reprogram-Diabetes)
- Anca Catrina – Towards prevention of autoimmune diseases; the case of rheumatoid arthritis (PREVENT RA)
2016
- Björn Högberg – Cellular Position Tracking Using DNA Origami Barcodes (CellTrack)
2015
- Gonçalo Castelo-Branco – EPIScOPE - Reversing the epigenetic state of oligodendrocyte precursors cells in multiple sclerosis
- Weimin Ye – Understanding microbe-induced stomach cancer; the key to a workable strategy for worldwide prevention
2014
- Rickard Sandberg – Revealing allele-level regulation and dynamics using single-cell gene expression analyses
- Per Svenningsson – Prosaposin and GPR37 in synucleinopathies
2013
- Martin Lövdén – Releasing the brakes on adult plasticity
- Ana Teixeira – Mechanotransduction in cell-to-cell communication
ERC Starting Grant
ERC StG riktar sig till unga forskare som är redo att starta en oberoende forskning och omfattar för närvarande upp till 1,5 miljoner Euro under en femårsperiod. Vid KI har följande forskare erhållit ERC Starting Grant:
2021
Marcus Buggert – Tracing virus-specific CD8+ T cell clonotype zonation and function in humans (TRACE).
2020
- Niklas Björkström – Dissecting tissue-resident lymphocyte homeostasis in humans (RESIDE)
- Janina Seubert – Olfaction as the link between flavour preference formation and retrieval during food consumption (OLFLINK)
- Nils Landegren – Deciphering sex differences in the human immune system (SEXimmune)
2019
- Jenny Mjösberg – Single-cell analysis of intestinal lymphocytes reveals targets for treatment of inflammatory bowel disease (GUT-SEQ).
- Maria Genander – Redefining the esophageal stem cell niche – towards targeting of squamous cell carcinoma (TroyCAN)
- Pia Dosenovic – Vaccine development against variable pathogens (VIVA).
2018
Fang Fang – Unraveling the Interplay between Metabolism, Gut Microbiome och Adaptive Immunity i Amyotrophic Lateral Sclerosis (MegaALS)
2017
- Erik Melén – Biomarkers for respiratory disease
- Georgios Sotiriou – Fighting infections and antimicrobial resistance with nanoengineering
2016
- Magda Bienko – Illuminating GENome Organization through integrated MIcroscopy and Sequencing
- Simon Elsässer – Chromatin dynamics resolved by rapid protein labeling and bioorthogonal capture
- Anna Wredenberg – Mitochondrial methylation and its role in health and disease
2015
- Petter Brodin – Shaping of the human immune system by primal environmental exposures in the newborn child
- Lars Maegdefessel – Therapeutic and biomarker potential of long non-coding RNAs in vascular disease
2013
- Marie Carlén – The role of parvalbumin interneurons in cognition and behaviour
- Erik Ingelsson (idag vid Uppsala universitet)
2012
- Pontus Boström – Irisin - a novel myokine protective against metabolic disease (har lämnat KI)
- Yenan Bryceson – Next generation sequencing for detection of human primary immunodeficiency syndromes
- Christian Göritz – The role of pericytes in central nervous system scarring and fibrosis
- Kristian Pietras – Exploring the tumor as a communicating organ (nu vid Lunds universitet)
- Tomas Renné – Factor XII and the contact system (har lämnat KI)
2011
- Andreas Olsson – Emotional learning in social interaction
- Gilad Silberberg – Sensory integration in the striatal microcircuit
- Andras Simon – Novel strategies for brain regeneration
2010
- Christian Broberger – Network principles of neuroendocrine control
- Luca Jovine – Molecular basis of mammalian egg-sperm interaction
- Sten Linnarsson – Charting the landscape of brain development
- Kirsty Spalding – Adipose tissue mass regulation in lean and obese individuals
2009
- Qiang Pan-Hammarström – Switch recombination: A model for DNA editing and repair in human lymphocytes
- Rickard Sandberg – Single-cell gene regulation in differentiation and pluripotency
2007
- Henrik Ehrsson – Neural mechanisms of body ownership
- Camilla Sjögren – Genomic stability: chromosome segregation and repair
ERC Proof of Concept
ERC Proof of Concept vänder sig till forskare som redan beviljats medel från ERC, och som vill undersöka innovationspotentialen i sina ERC-finansierade projekt. Anslaget omfattar upp till 150 000 Euro. Vid KI har följande forskare erhållit ERC Proof of Concept:
2020
- Simon Elsässer – Highly multiplexed, quantitative epigenetic profiling
Nyhetsartikel på engelska - Thomas Helleday – Development of small molecule OGG1 Inhibitor and proof of concept in bleomycin-induced disease model of Inflammation and pulmonary Fibrosis (DOIIF)
Nyhetsartikel: Nytt koncept för att behandla allvarlig lunginflammation och fibros
2016
- Per-Olof Berggren – Validation of an in vivo translational medicine approach for the treatment of diabetes and diabetes complications
- Thomas Helleday – Novel viral therapy through targeting DNA repair (NOVITREP)
2015
- Thomas Helleday – Commercializing first-in-class dCTPase Inhibitors for treatment of hematological Cancers
2014
- Patrik Ernfors – Validation of a conceptually new treatment for glioblastoma multiforma
2013
- Thomas Helleday – Proof of concept use of MTH1 inhibitors as new treatments for cancer
2012
- Lars Klareskog – Prevent Rheumatoid Arthritis in Practice