Bioinformatics Platform
Driven by the technological development in DNA and RNA sequencing, single cell technologies, as well as high-throughput screenings, increasingly complex datasets are generated at a fast pace within life/biomedical sciences. In order to analyse these datasets, researchers in these fields are facing growing demands for computational expertise.
The goal of the bioinformatics platform was to provide highly-specialised bioinformatics support in the areas of genomics, epigenomics, transcriptomics, proteomics, high-throughput screen deconvolution and systems biology. Furthermore, it served as a knowledge base that connected the bioinformatics know-how already present in individual research groups of MWLC in Stockholm and Hong Kong. The core of the platform was formed by one computational biologist and two bioinformaticians who were organising a network between the two nodes and closely collaborating with the researchers of the MWLC.
People
Previous members
Virpi Ahola | Computational Biologist
Tapan Baral | Bioinformatician
Shangli Cheng | Postdoctoral Researcher in Bioinformatics
Aman Zare | Bioinformatician
Jilin Zhang | Bioinformatician
Photo: Patrick ChanBioinformatics Platform's new publication in iScience
Our Bioinformatics Platform analysed and compared the single-cell RNA sequencing data derived from different engineered human cardiac tissue configurations, and found that the maturation state of cardiomyocyte increases with increasing levels of complexity of the engineered tissues, from cardiac spheroids to cardiac organoid chamber. The study showed that these tissue engineering models resembling configurations of native human tissues may be reliable for drug screening or disease modelling.
Bioinformatics Seminar Series
The Bioinformatics seminar series connected bioinformaticians and other researchers working on bioinformatics related issues in Hong Kong and Stockholm. The participants were mostly from MWLC research groups and our close collaborators.