Human innate lymphoid cell lab – Jenny Mjösberg group

The research conducted in the Jenny Mjösberg group aims to characterize the role for innate lymphoid cells (ILCs) in intestinal inflammation, cancer and asthma. Our research objective is ultimately to increase the understanding of disease mechanisms, discovering novel treatment targets and strategies for patient stratification in biologics treatment.

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Department of Medicine, Huddinge

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Publications

Selected publications

Article: PLOS PATHOGENS. 2024;20(7):e1012390
Innate lymphoid cells are activated in HFRS, and their function can be modulated by hantavirus-induced type I interferons
Garcia M; Garcia AC; Weigel W; Christ W; Lira-Junior R; Wirth L; Tauriainen J; Maleki K; Vanoni G; Vaheri A; Makela S; Mustonen J; Nordgren J; Smed-Sorensen A; Strandin T; Mjosberg J; Klingstrom J
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2024;54(4):e2350660
Single-cell RNA sequencing of cells from fresh or frozen tissue reveals a signature of freezing marked by heightened stress and activation
Stamper CT; Marchalot A; Tibbitt CA; Weigel W; Jangard M; Theorell J; Mjosberg J
Article: ALLERGY. 2023;78(9):2533-2536
Innate lymphoid cells type 2 and CD8+ T cells are perturbed in overweight and obese individuals with asthma.
Björkander S; Maier P; Kere M; Merid SK; Wirth L; Wiegel W; Ekström S; Kull I; Bergström A; Melén E; Mjösberg J; Tibbitt CA
Article: CELL REPORTS MEDICINE. 2023;4(5):101038
The single-cell transcriptional landscape of innate and adaptive lymphocytes in pediatric-onset colitis
Kokkinou E; Soini T; Pandey RV; van Acker A; Theorell J; Czarnewski P; Kvedaraite E; Vandamme N; Lourda M; Sorini C; Weigel W; Carrasco A; Tibbitt CA; Schlums H; Lindforss U; Nordenvall C; Ljunggren M; Idestrom M; Svensson M; Henter J-I; Villablanca EJ; Bryceson YT; Rolandsdotter H; Mjosberg J
Article: SCIENCE IMMUNOLOGY. 2022;7(70):eabj8301
CD45RA⁺CD62L^- ILCs in human tissues represent a quiescent local reservoir for the generation of differentiated ILCs
Kokkinou E; Pandey RV; Mazzurana L; Gutierrez-Perez I; Tibbitt CA; Weigel W; Soini T; Carrasco A; Rao A; Nagasawa M; Bal SM; Jangard M; Friberg D; Lindforss U; Nordenvall C; Ljunggren M; Haapaniemi S; Keita AV; Soderholm J; Hedin C; Spits H; Bryceson YT; Mjosberg J
Article: CELL RESEARCH. 2021;31(5):554-568
Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing
Mazzurana L; Czarnewski P; Jonsson V; Wigge L; Ringner M; Williams TC; Ravindran A; Bjorklund AK; Safholm J; Nilsson G; Dahlen S-E; Orre A-C; Al-Ameri M; Hoog C; Hedin C; Szczegielniak S; Almer S; Mjosberg J
Article: NATURE COMMUNICATIONS. 2020;11(1):2049
Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs
Rao A; Strauss O; Kokkinou E; Bruchard M; Tripathi KP; Schlums H; Carrasco A; Mazzurana L; Konya V; Villablanca EJ; Bjorkstrom NK; Lindforss U; Spits H; Mjosberg J
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;143(6):2202-2214.e5
Cytokine-induced endogenous production of prostaglandin D₂ is essential for human group 2 innate lymphoid cell activation
Maric J; Ravindran A; Mazzurana L; Van Acker A; Rao A; Kokkinou E; Ekoff M; Thomas D; Fauland A; Nilsson G; Wheelock CE; Dahlen S-E; Ferreiros N; Geisslinger G; Friberg D; Heinemann A; Konya V; Mjosberg J
Article: JOURNAL OF CROHNS & COLITIS. 2019;13(1):67-78
Distinct Alterations in the Composition of Mucosal Innate Lymphoid Cells in Newly Diagnosed and Established Crohn's Disease and Ulcerative Colitis
Forkel M; van Tol S; Hoog C; Michaelsson J; Almer S; Mjosberg J
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2018;141(5):1761-1773.e6
Prostaglandin E₂ suppresses human group 2 innate lymphoid cell function
Maric J; Ravindran A; Mazzurana L; Bjorklund AK; Van Acker A; Rao A; Friberg D; Dahlen S-E; Heinemann A; Konya V; Mjosberg J
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2018;141(1):279-292
Vitamin D downregulates the IL-23 receptor pathway in human mucosal group 3 innate lymphoid cells
Konya V; Czarnewski P; Forkel M; Rao A; Kokkinou E; Villablanca EJ; Almer S; Lindforss U; Friberg D; Hoeoeg C; Bergman P; Mjoesberg J
Corrigendum: NATURE IMMUNOLOGY. 2016;17(6):740
The heterogeneity of human CD127⁺ innate lymphoid cells revealed by single-cell RNA sequencing (vol 17, pg 451, 2016)
Bjorklund AK; Forkel M; Picelli S; Konya V; Theorell J; Friberg D; Sandberg R; Mjosberg J
Article: IMMUNITY. 2012;37(4):649-659
The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells.
Mjösberg J; Bernink J; Golebski K; Karrich JJ; Peters CP; Blom B; te Velde AA; Fokkens WJ; van Drunen CM; Spits H
Article: NATURE IMMUNOLOGY. 2011;12(11):1055-1062
Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161.
Mjösberg JM; Trifari S; Crellin NK; Peters CP; van Drunen CM; Piet B; Fokkens WJ; Cupedo T; Spits H