Disease mechanisms in severe acute bacterial infections – Anna Norrby-Teglund group

Publications

Selected publications

• Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2021;65(11):e0065821-10.1128/aac.00621

  Adjunctive Rifampicin Increases Antibiotic Efficacy in Group A Streptococcal Tissue Infection Models

  Bergsten H; Medina LMP; Morgan M; Moll K; Skutlaberg DH; Skrede S; Wajima T; Svensson M; Norrby-Teglund A
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(40):e2109123118

  High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of in COVID-19

  Lourda M; Dzidic M; Hertwig L; Bergsten H; Medina LMP; Sinha I; Kvedaraite E; Chen P; Muvva JR; Gorin J-B; Cornillet M; Emgard J; Moll K; Garcia M; Maleki KT; Klingstrom J; Michaelsson J; Flodstrom-Tullberg M; Brighenti S; Buggert M; Mjosberg J; Malmberg K-J; Sandberg JK; Henter J-I; Folkesson E; Gredmark-Russ S; Sonnerborg A; Eriksson LI; Rooyackers O; Aleman S; Stralin K; Ljunggren H-G; Bjorkstrom NK; Svensson M; Ponzetta A; Norrby-Teglund A; Chambers BJ
• Article: JOURNAL OF CLINICAL INVESTIGATION. 2021;131(14):149523

  Discriminatory plasma biomarkers predict specific clinical phenotypes of necrotizing soft-tissue infections

  Medina LMP; Rath E; Jahagirdar S; Bruun T; Madsen MB; Stralin K; Unge C; Hansen MB; Arnell P; Nekludov M; Hyldegaard O; Lourda M; Santos VAPMD; Saccenti E; Skrede S; Svensson M; Norrby-Teglund A
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(6):e2018587118

  Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity

  Kvedaraite E; Hertwig L; Sinha I; Ponzetta A; Myrberg IH; Lourda M; Dzidic M; Akber M; Klingstrom J; Folkesson E; Muvva JR; Chen P; Gredmark-Russ S; Brighenti S; Norrby-Teglund A; Eriksson LI; Rooyackers O; Aleman S; Stralin K; Ljunggren H-G; Ginhoux F; Bjorkstrom NK; Henter J-I; Svensson M
• Article: CLINICAL INFECTIOUS DISEASES. 2021;72(2):293-300

  Risk Factors and Predictors of Mortality in Streptococcal Necrotizing Soft-tissue Infections: A Multicenter Prospective Study

  Bruun T; Rath E; Madsen MB; Oppegaard O; Nekludov M; Arnell P; Karlsson Y; Babbar A; Bergey F; Itzek A; Hyldegaard O; Norrby-Teglund A; Skrede S
• Editorial comment: CLINICAL INFECTIOUS DISEASES. 2020;71(7):1772-1775

  Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections

  Bergsten H; Madsen MB; Bergey F; Hyldegaard O; Skrede S; Arnell P; Oppegaard O; Itzek A; Perner A; Svensson M; Norrby-Teglund A
• Editorial comment: CLINICAL INFECTIOUS DISEASES. 2020;70(7):1461-1462

  Is It Time to Reconsider the Group A Streptococcal Rheumatogenic Concept?

  Norrby-Teglund A; Siemens N
• Article: JOURNAL OF PROTEOME RESEARCH. 2020;19(2):688-698

  Integrated Univariate, Multivariate, and Correlation-Based Network Analyses Reveal Metabolite-Specific Effects on Bacterial Growth and Biofilm Formation in Necrotizing Soft Tissue Infections

  Afzal M; Saccenti E; Madsen MB; Hansen MB; Hyldegaard O; Skrede S; dos Santos VAPM; Norrby-Teglund A; Svensson M
• Article: JOURNAL OF INNATE IMMUNITY. 2020;12(4):291-303

  Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment

  Siemens N; Oehmcke-Hecht S; Hossmann J; Skorka SB; Nijhuis RHT; Ruppen C; Skrede S; Rohde M; Schultz D; Lalk M; Itzek A; Pieper DH; van den Bout CJ; Claas ECJ; Kuijper EJ; Mauritz R; Sendi P; Wunderink HF; Norrby-Teglund A
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(51):25923-25931

  MAIT Cells Are Major Contributors to the Cytokine Response in Group A Streptococcal Toxic Shock Syndrome

  Emgard J; Bergsten H; McCormick JK; Barrantes I; Skrede S; Sandberg JK; Norrby-Teglund A
• Article: INTENSIVE CARE MEDICINE. 2019;45(9):1241-1251

  Patient's characteristics and outcomes in necrotising soft-tissue infections: results from a Scandinavian, multicentre, prospective cohort study

  Madsen MB; Skrede S; Perner A; Arnell P; Nekludov M; Bruun T; Karlsson Y; Hansen MB; Polzik P; Hedetoft M; Rosen A; Saccenti E; Bergey F; dos Santos VAPM; Norrby-Teglund A; Hyldegaard O; Bidstrup D; Baernthsen NF; Frendo GH; Jansen EC; Madsen LB; Mueller RB; Pedersen EMJ; Petersen MW; Ravn F; Smidt-Nielsen IFG; Wahl AM; Wulffeld S; Aronsson S; Rosemar A; Trogen J; Nedrebo T; Oppegaard O; Rath E; Saevik M
• Article: NATURE COMMUNICATIONS. 2019;10(1):3846

  Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections

  Thaenert R; Itzek A; Hossmann J; Hamisch D; Madsen MB; Hyldegaard O; Skrede S; Bruun T; Norrby-Teglund A; Medina E; Pieper DH; Oppegaard O; Rath E; Nedrebo T; Arnell P; Rosen A; Polzik P; Hansen MB; Svensson M; Snall J; Karlsson Y; Nekludov M
• Article: JOURNAL OF INFECTIOUS DISEASES. 2019;220(4):710-719

  Necrotizing Soft Tissue Infection Staphylococcus aureus but not S. pyogenes Isolates Display High Rates of Internalization and Cytotoxicity Toward Human Myoblasts

  Baude J; Bastien S; Gillet Y; Leblanc P; Itzek A; Tristan A; Bes M; Duguez S; Moreau K; Diep BA; Norrby-Teglund A; Henry T; Vandenesch F; Arnell P; Bergey F; Dos Santos VAPM; Hyldegaard O; Nekludov M; Pieper D; Skrede S; Svensson M
• Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2019;139(6):1284-1293

  Group A Streptococcal DNase Sda1 Impairs Plasmacytoid Dendritic Cells' Type 1 Interferon Response

  Keller N; Woytschak J; Heeb LEM; Maggio EM; Shambat SM; Snall J; Hyldegaard O; Boyman O; Norrby-Teglund A; Zinkernagel AS
• Article: CLINICAL MICROBIOLOGY AND INFECTION. 2019;25(4):512.e7-512.e13

  Human polyspecific immunoglobulin attenuates group A streptococcal virulence factor activity and reduces disease severity in a murine necrotizing fasciitis model

  Tarnutzer A; Andreoni F; Keller N; Zuercher C; Norrby-Teglund A; Schuepbach RA; Zinkernagel AS
• Review: CLINICAL INFECTIOUS DISEASES. 2018;67(9):1434-1436

  Polyspecific Intravenous Immunoglobulin in Clindamycin-treated Patients With Streptococcal Toxic Shock Syndrome: A Systematic Review and Meta-analysis

  Parks T; Wilson C; Curtis N; Norrby-Teglund A; Sriskandan S
• Article: SCIENTIFIC REPORTS. 2018;8(1):13428

  High HMGB1 levels in sputum are related to pneumococcal bacteraemia but not to disease severity in community-acquired pneumonia

  Alpkvist H; Athlin S; Molling P; Norrby-Teglund A; Stralin K
• Article: FRONTIERS IN IMMUNOLOGY. 2018;9:236

  Protein SIC Secreted from Streptococcus pyogenes Forms Complexes with Extracellular Histones That Boost Cytokine Production

  Westman J; Chakrakodi B; Snall J; Morgelin M; Madsen MB; Hyldegaard O; Neumann A; Frick I-M; Norrby-Teglund A; Bjorck L; Herwald H
• Article: JOURNAL OF INNATE IMMUNITY. 2018;10(1):30-43

  Immunoregulation of Neutrophil Extracellular Trap Formation by Endothelial-Derived p33 (gC1q Receptor)

  Neumann A; Papareddy P; Westman J; Hyldegaard O; Snall J; Norrby-Teglund A; Herwald H
• Article: INTENSIVE CARE MEDICINE. 2017;43(11):1585-1593

  Immunoglobulin G for patients with necrotising soft tissue infection (INSTINCT): a randomised, blinded, placebo-controlled trial

  Madsen MB; Hjortrup PB; Hansen MB; Lange T; Norrby-Teglund A; Hyldegaard O; Perner A
• Editorial comment: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(38):10000-10002

  Shocking superantigens promote establishment of bacterial infection

  Siemens N; Norrby-Teglund A
• Article: BMC MEDICINE. 2017;15(1):172

  Macrophage activation-like syndrome: an immunological entity associated with rapid progression to death in sepsis

  Kyriazopoulou E; Leventogiannis K; Norrby-Teglund A; Dimopoulos G; Pantazi A; Orfanos SE; Rovina N; Tsangaris I; Gkavogianni T; Botsa E; Chassiou E; Kotanidou A; Kontouli C; Chaloulis P; Velissaris D; Savva A; Cullberg J-S; Akinosoglou K; Gogos C; Armaganidis A; Giamarellos-Bourboulis EJ
• Article: PLOS BIOLOGY. 2017;15(7):e2003167

  Bacterial deception of MAIT cells in a cloud of superantigen and cytokines

  Sandberg JK; Norrby-Teglund A; Leeansyah E
• Article: BLOOD. 2017;129(14):1991-2001

  Neutrophils acquire the capacity for antigen presentation to memory CD4⁺ T cells in vitro and ex vivo

  Vono M; Lin A; Norrby-Teglund A; Koup RA; Liang F; Lore K
• Article: CRITICAL CARE MEDICINE. 2017;45(4):591-599

  Fever in the Emergency Department Predicts Survival of Patients With Severe Sepsis and Septic Shock Admitted to the ICU

  Sunden-Cullberg J; Rylance R; Svefors J; Norrby-Teglund A; Bjork J; Inghammar M
• Article: SCIENTIFIC REPORTS. 2017;7:42179

  Association between cytokine response, the LRINEC score and outcome in patients with necrotising soft tissue infection: a multicentre, prospective study

  Hansen MB; Rasmussen LS; Svensson M; Chakrakodi B; Bruun T; Madsen MB; Perner A; Garred P; Hyldegaard O; Norrby-Teglund A
• Article: JOURNAL OF INFECTIOUS DISEASES. 2016;214(12):1876-1883

  Phosphoglycerate Kinase-A Novel Streptococcal Factor Involved in Neutrophil Activation and Degranulation

  Uhlmann J; Siemens N; Kai-Larsen Y; Fiedler T; Bergman P; Johansson L; Norrby-Teglund A
• Article: SCIENTIFIC REPORTS. 2016;6:31360

  A point mutation in AgrC determines cytotoxic or colonizing properties associated with phenotypic variants of ST22 MRSA strains

  Shambat SM; Siemens N; Monk IR; Mohan DB; Mukundan S; Krishnan KC; Prabhakara S; Snall J; Kearns A; Vandenesch F; Svensson M; Kotb M; Gopal B; Arakere G; Norrby-Teglund A
• Article: JCI INSIGHT. 2016;1(10):e87882

  Biofilm in group A streptococcal necrotizing soft tissue infections

  Siemens N; Chakrakodi B; Shambat SM; Morgan M; Bergsten H; Hyldegaard O; Skrede S; Arnell P; Madsen MB; Johansson L; Juarez J; Bosnjak L; Morgelin M; Svensson M; Norrby-Teglund A
• Article: PLOS PATHOGENS. 2016;12(7):e1005732

  Genetic Architecture of Group A Streptococcal Necrotizing Soft Tissue Infections in the Mouse

  Krishnan KC; Mukundan S; Alagarsamy J; Hur J; Nookala S; Siemens N; Svensson M; Hyldegaard O; Norrby-Teglund A; Kotb M
• Article: SCIENTIFIC REPORTS. 2016;6:21288

  Differential neutrophil responses to bacterial stimuli: Streptococcal strains are potent inducers of heparin-binding protein and resistin-release

  Snall J; Linner A; Uhlmann J; Siemens N; Ibold H; Janos M; Linder A; Kreikemeyer B; Herwald H; Johansson L; Norrby-Teglund A
• Article: JOURNAL OF INNATE IMMUNITY. 2016;8(3):243-257

  LL-37 Triggers Formation of Streptococcus pyogenes Extracellular Vesicle-Like Structures with Immune Stimulatory Properties

  Uhlmann J; Rohde M; Siemens N; Kreikemeyer B; Bergman P; Johansson L; Norrby-Teglund A
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Staff and contact

Group leader

• 

  Anna Norrby-Teglund

  Professor

  Telephone +46852482354

  E-mail anna.norrby-teglund@ki.se

All members of the group

• 

  Anna Bergonzini

  Postdoctoral Researcher

  E-mail anna.bergonzini@ki.se
• 

  Benedict Chambers

  Researcher | Arvodist | Docent

  E-mail benedict.chambers@ki.se
• Alyssa Cho

  Phd Student

  E-mail alyssa.cho@ki.se
• 

  Rageia Elfageih

  Senior Lab Manager

  Telephone +46852483865

  E-mail rageia.elfageih@ki.se
• Jin-Hong Min

  Research Specialist

  E-mail jinhong.min@ki.se
• 

  Kirsten Moll

  Senior Lab Manager

  E-mail kirsten.moll@ki.se
• Anh Nguyen Wartel

  Affiliated to Research

  E-mail anh.wartel@ki.se
• 

  Anna Norrby-Teglund

  Professor

  Telephone +46852482354

  E-mail anna.norrby-teglund@ki.se
• 

  Laura Palma Medina

  Assistant Professor

  E-mail laura.palma.medina@ki.se
• Laura Plant

  Affiliated to Research

  E-mail laura.plant@ki.se
• Eve-Marie Rowe Kärkäs

  Administrator

  Telephone +46852483866

  E-mail evemarie.rowe.karkas@ki.se
• Lisa Seidner

  Phd Student

  E-mail lisa.seidner@ki.se
• 

  Anirban Sengupta

  Postdoctoral Researcher

  E-mail anirban.sengupta@ki.se
• Olga Shilkova

  Senior Lab Manager

  Telephone +46852483765

  E-mail olga.shilkova@ki.se
• Carl Johan Treutiger

  Affiliated to Research | Docent

  E-mail carl.treutiger@ki.se