Benedict Chambers

About me
Publications
CV
Public outreach and news

Research

Our group studies how immune cells interact with each other and how we can manipulate these interactions to enhance host responses to cancer and infections

Teaching

I am an award winning teacher and educate at all levels at Karolinska Institute. My areas of expertese are within immunology and infection biology.
I am also responsible for the Amgen Scholars program at the Karolinska Institutet.

Articles

Article: JOURNAL OF INFECTIOUS DISEASES. 2024;:jiae036

Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19.

Strunz B; Maucourant C; Mehta A; Wan H; Du L; Sun D; Chen P; Nordlander A; Gao Y; Cornillet M; Bister J; Kvedaraite E; Christ W; Klingström J; Geanon D; Parke Å; Ekwall-Larson A; Rivino L; MacAry PA; Aleman S; Buggert M; Ljunggren H-G; Pan-Hammarström Q; Lund-Johansen F; Strålin K; Björkström NK; Karolinska KI/K COVID-19 Study Group
Article: ACS NANO. 2023;17(17):17451-17467

Exploiting Mass Spectrometry to Unlock the Mechanism of Nanoparticle-Induced Inflammasome Activation.

Gupta G; Kaur J; Bhattacharya K; Chambers BJ; Gazzi A; Furesi G; Rauner M; Fuoco C; Orecchioni M; Delogu LG; Haag L; Stehr JE; Thomen A; Bordes R; Malmberg P; Seisenbaeva GA; Kessler VG; Persson M; Fadeel B
Article: RESPIRATORY RESEARCH. 2023;24(1):62

Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia.

Palma Medina LM; Babačić H; Dzidic M; Parke Å; Garcia M; Maleki KT; Unge C; Lourda M; Kvedaraite E; Chen P; Muvva JR; Cornillet M; Emgård J; Moll K; Karolinska K. I./K. COVID-19 Study Group; Michaëlsson J; Flodström-Tullberg M; Brighenti S; Buggert M; Mjösberg J; Malmberg K-J; Sandberg JK; Gredmark-Russ S; Rooyackers O; Svensson M; Chambers BJ; Eriksson LI; Pernemalm M; Björkström NK; Aleman S; Ljunggren H-G; Klingström J; Strålin K; Norrby-Teglund A
Article: ISCIENCE. 2023;26(2):106071

Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment.

Fernandes S; Srivastava N; Pedicone C; Sudan R; Luke EA; Dungan OM; Pacherille A; Meyer ST; Dormann S; Schurmans S; Chambers BJ; Chisholm JD; Kerr WG
Journal article: ACS NANO. 2023

Exploiting Mass Spectrometry to Unlock the Mechanism of Nanoparticle-Induced Inflammasome Activation

Gupta G; Kaur J; Bhattacharya K; Chambers BJ; Gazzi A; Furesi G; Rauner M; Fuoco C; Orecchioni M; Delogu LG; Haag L; Stehr JE; Thomen A; Bordes R; Malmberg P; Seisenbaeva GA; Kessler VG; Persson M; Fadeel B
Article: ISCIENCE. 2022;25(10):105137

PD-1 expression on mouse intratumoral NK cells and its effects on NK cell phenotype.

Wagner AK; Kadri N; Tibbitt C; van de Ven K; Bagawath-Singh S; Oliinyk D; LeGresley E; Campbell N; Trittel S; Riese P; Ribacke U; Sandalova T; Achour A; Kärre K; Chambers BJ
Article: NATURE COMMUNICATIONS. 2022;13(1):5093

HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection.

Liu R; Muliadi V; Mou W; Li H; Yuan J; Holmberg J; Chambers BJ; Ullah N; Wurth J; Alzrigat M; Schlisio S; Carow B; Larsson LG; Rottenberg ME
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2022;96(1):e13195

The Karolinska KI/K COVID-19 Immune Atlas: An open resource for immunological research and educational purposes.

Ljunggren H-G; Ask EH; Cornillet M; Strunz B; Chen P; Rao Muvva J; Akber M; Buggert M; Chambers BJ; Cuapio A; Dzidic M; Filipovic I; Flodström-Tullberg M; Garcia M; Gorin J-B; Gredmark-Russ S; Hertwig L; Klingström J; Kokkinou E; Kvedaraite E; Lourda M; Mjösberg J; Maucourant C; Norrby-Teglund A; Palma Medina LM; Parrot T; Perez-Potti A; Ponzetta A; Ringqvist E; Rivera-Ballesteros O; Rooyackers O; Sandberg JK; Sandberg JT; Sekine T; Svensson M; Varnaite R; Wullimann D; Karolinska KI/K COVID-19 Study Group; Eriksson LI; Aleman S; Malmberg K-J; Strålin K; Björkström NK
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2022;52(3):503-510

COVID-19-specific metabolic imprint yields insights into multiorgan system perturbations.

Cornillet M; Strunz B; Rooyackers O; Ponzetta A; Chen P; Muvva JR; Akber M; Buggert M; Chambers BJ; Dzidic M; Filipovic I; Gorin J-B; Gredmark-Russ S; Hertwig L; Klingström J; Kokkinou E; Kvedaraite E; Lourda M; Mjösberg J; Maucourant C; Norrby-Teglund A; Parrot T; Perez-Potti A; Rivera-Ballesteros O; Sandberg JK; Sandberg JT; Sekine T; Svensson M; Varnaite R; Karolinska KI/K COVID-19 Study Group; Eriksson LI; Aleman S; Strålin K; Ljunggren H-G; Björkström NK
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:854312

FOXO1 and FOXO3 Cooperatively Regulate Innate Lymphoid Cell Development.

Luu TT; Søndergaard JN; Peña-Pérez L; Kharazi S; Krstic A; Meinke S; Schmied L; Frengen N; Heshmati Y; Kierczak M; Bouderlique T; Wagner AK; Gustafsson C; Chambers BJ; Achour A; Kutter C; Höglund P; Månsson R; Kadri N
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(40):e2109123118

High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19.

Lourda M; Dzidic M; Hertwig L; Bergsten H; Palma Medina LM; Sinha I; Kvedaraite E; Chen P; Muvva JR; Gorin J-B; Cornillet M; Emgård J; Moll K; García M; Maleki KT; Klingström J; Michaëlsson J; Flodström-Tullberg M; Brighenti S; Buggert M; Mjösberg J; Malmberg K-J; Sandberg JK; Henter J-I; Folkesson E; Gredmark-Russ S; Sönnerborg A; Eriksson LI; Rooyackers O; Aleman S; Strålin K; Ljunggren H-G; Björkström NK; Svensson M; Ponzetta A; Norrby-Teglund A; Chambers BJ; Karolinska KI/K COVID-19 Study Group
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2021;110(4):617-628

GABAergic signaling in human and murine NK cells upon challenge with Toxoplasma gondii.

Bhandage AK; Friedrich LM; Kanatani S; Jakobsson-Björkén S; Escrig-Larena JI; Wagner AK; Chambers BJ; Barragan A
Article: JOURNAL OF CELL SCIENCE. 2021;134(11):jcs257428

The murine cytomegalovirus immunoevasin gp40/m152 inhibits NKG2D receptor RAE-1γ by intracellular retention and cell surface masking.

Lis N; Hein Z; Ghanwat SS; Ramnarayan VR; Chambers BJ; Springer S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(6):e2018587118

Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity.

Kvedaraite E; Hertwig L; Sinha I; Ponzetta A; Hed Myrberg I; Lourda M; Dzidic M; Akber M; Klingström J; Folkesson E; Muvva JR; Chen P; Gredmark-Russ S; Brighenti S; Norrby-Teglund A; Eriksson LI; Rooyackers O; Aleman S; Strålin K; Ljunggren H-G; Ginhoux F; Björkström NK; Henter J-I; Svensson M; Karolinska KI/K COVID-19 Study Group
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:727300

High Dimensional Immune Profiling Reveals Different Response Patterns in Active and Latent Tuberculosis Following Stimulation With Mycobacterial Glycolipids.

Silva CS; Sundling C; Folkesson E; Fröberg G; Nobrega C; Canto-Gomes J; Chambers BJ; Lakshmikanth T; Brodin P; Bruchfeld J; Nigou J; Correia-Neves M; Källenius G
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1306

SARS-CoV-2-specific humoral and cellular immunity persists through 9 months irrespective of COVID-19 severity at hospitalisation.

Sandberg JT; Varnaitė R; Christ W; Chen P; Muvva JR; Maleki KT; García M; Dzidic M; Folkesson E; Skagerberg M; Ahlén G; Frelin L; Sällberg M; Eriksson LI; Rooyackers O; Sönnerborg A; Buggert M; Björkström NK; Aleman S; Strålin K; Klingström J; Ljunggren H-G; Blom K; Gredmark-Russ S; Karolinska COVID‐19 Study Group
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(50):32005-32016

Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells.

Eisinger S; Sarhan D; Boura VF; Ibarlucea-Benitez I; Tyystjärvi S; Oliynyk G; Arsenian-Henriksson M; Lane D; Wikström SL; Kiessling R; Virgilio T; Gonzalez SF; Kaczynska D; Kanatani S; Daskalaki E; Wheelock CE; Sedimbi S; Chambers BJ; Ravetch JV; Karlsson MCI
Article: CELL. 2020;183(1):158-168.e14

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19.

Sekine T; Perez-Potti A; Rivera-Ballesteros O; Strålin K; Gorin J-B; Olsson A; Llewellyn-Lacey S; Kamal H; Bogdanovic G; Muschiol S; Wullimann DJ; Kammann T; Emgård J; Parrot T; Folkesson E; Karolinska COVID-19 Study Group; Rooyackers O; Eriksson LI; Henter J-I; Sönnerborg A; Allander T; Albert J; Nielsen M; Klingström J; Gredmark-Russ S; Björkström NK; Sandberg JK; Price DA; Ljunggren H-G; Aleman S; Buggert M
Article: SCIENCE IMMUNOLOGY. 2020;5(51):eabe1670

MAIT cell activation and dynamics associated with COVID-19 disease severity.

Parrot T; Gorin J-B; Ponzetta A; Maleki KT; Kammann T; Emgård J; Perez-Potti A; Sekine T; Rivera-Ballesteros O; Karolinska COVID-19 Study Group; Gredmark-Russ S; Rooyackers O; Folkesson E; Eriksson LI; Norrby-Teglund A; Ljunggren H-G; Björkström NK; Aleman S; Buggert M; Klingström J; Strålin K; Sandberg JK
Article: SCIENCE IMMUNOLOGY. 2020;5(50):eabd6832

Natural killer cell immunotypes related to COVID-19 disease severity.

Maucourant C; Filipovic I; Ponzetta A; Aleman S; Cornillet M; Hertwig L; Strunz B; Lentini A; Reinius B; Brownlie D; Cuapio A; Ask EH; Hull RM; Haroun-Izquierdo A; Schaffer M; Klingström J; Folkesson E; Buggert M; Sandberg JK; Eriksson LI; Rooyackers O; Ljunggren H-G; Malmberg K-J; Michaëlsson J; Marquardt N; Hammer Q; Strålin K; Björkström NK; Karolinska COVID-19 Study Group
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2020;50(4):494-504

IL-15 and CD155 expression regulate LAT expression in murine DNAM1+ NK cells, enhancing their effectors functions.

Luu TT; Wagner AK; Schmied L; Meinke S; Freund JE; Kambayashi T; Ravens I; Achour A; Bernhardt G; Chambers BJ; Höglund P; Kadri N
Article: IMMUNITY INFLAMMATION AND DISEASE. 2020;8(1):8-23

PD-1 expression affects cytokine production by ILC2 and is influenced by peroxisome proliferator-activated receptor-γ.

Batyrova B; Luwaert F; Maravelia P; Miyabayashi Y; Vashist N; Stark JM; Soori SY; Tibbitt CA; Riese P; Coquet JM; Chambers BJ
Article: SCIENTIFIC REPORTS. 2019;9(1):16362

Key features and homing properties of NK cells in the liver are shaped by activated iNKT cells.

Trittel S; Chambers BJ; Heise U; Guzmán CA; Riese P
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1849

Invariant NKT Cell-Mediated Modulation of ILC1s as a Tool for Mucosal Immune Intervention.

Trittel S; Vashist N; Ebensen T; Chambers BJ; Guzmán CA; Riese P
Article: CANCER IMMUNOLOGY RESEARCH. 2018;6(11):1417-1425

Cripto-1 Plasmid DNA Vaccination Targets Metastasis and Cancer Stem Cells in Murine Mammary Carcinoma.

Witt K; Ligtenberg MA; Conti L; Lanzardo S; Ruiu R; Wallmann T; Tufvesson-Stiller H; Chambers BJ; Rolny C; Lladser A; Lundqvist A; Cavallo F; Kiessling R
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:505

Influenza-Activated ILC1s Contribute to Antiviral Immunity Partially Influenced by Differential GITR Expression.

Vashist N; Trittel S; Ebensen T; Chambers BJ; Guzmán CA; Riese P
Article: PLOS PATHOGENS. 2017;13(12):e1006739

Voltage-dependent calcium channel signaling mediates GABAA receptor-induced migratory activation of dendritic cells infected by Toxoplasma gondii.

Kanatani S; Fuks JM; Olafsson EB; Westermark L; Chambers B; Varas-Godoy M; Uhlén P; Barragan A
Article: INFECTION AND IMMUNITY. 2017;85(10):e00069-e00017

Downmodulation of Effector Functions in NK Cells upon Toxoplasma gondii Infection.

Sultana MA; Du A; Carow B; Angbjär CM; Weidner JM; Kanatani S; Fuks JM; Muliaditan T; James J; Mansfield IO; Campbell TM; Liu L; Kadri N; Lambert H; Barragan A; Chambers BJ
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(3):135-142

The Abl-1 Kinase is Dispensable for NK Cell Inhibitory Signalling and is not Involved in Murine NK Cell Education.

Ganesan S; Luu TT; Chambers BJ; Meinke S; Brodin P; Vivier E; Wetzel DM; Koleske AJ; Kadri N; Höglund P
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;85(6):417-424

TLR-Stimulated Eosinophils Mediate Recruitment and Activation of NK Cells In Vivo.

O'Flaherty SM; Sutummaporn K; Häggtoft WL; Worrall AP; Rizzo M; Braniste V; Höglund P; Kadri N; Chambers BJ
Article: NATURE COMMUNICATIONS. 2017;8:15627

Expression of CD226 is associated to but not required for NK cell education.

Wagner AK; Kadri N; Snäll J; Brodin P; Gilfillan S; Colonna M; Bernhardt G; Höglund P; Kärre K; Chambers BJ
Article: SCIENCE IMMUNOLOGY. 2017;2(9):eaal5196

PPAR-γ promotes type 2 immune responses in allergy and nematode infection.

Chen T; Tibbitt CA; Feng X; Stark JM; Rohrbeck L; Rausch L; Sedimbi SK; Karlsson MCI; Lambrecht BN; Karlsson Hedestam GB; Hendriks RW; Chambers BJ; Nylén S; Coquet JM
Article: SCIENTIFIC REPORTS. 2016;6:37996

Independent control of natural killer cell responsiveness and homeostasis at steady-state by CD11c+ dendritic cells.

Luu TT; Ganesan S; Wagner AK; Sarhan D; Meinke S; Garbi N; Hämmerling G; Alici E; Kärre K; Chambers BJ; Höglund P; Kadri N
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2016;100(4):781-789

Sensitivity of dendritic cells to NK-mediated lysis depends on the inflammatory environment and is modulated by CD54/CD226-driven interactions.

Smith LE; Olszewski MA; Georgoudaki A-M; Wagner AK; Hägglöf T; Karlsson MCI; Dominguez-Villar M; Garcia-Cozar F; Mueller S; Ravens I; Bernhardt G; Chambers BJ
Article: ACTA PAEDIATRICA. 2016;105(8):979-982

A ten-year retrospective case series of glucocorticoid treatment of bacterial meningitis in children.

Ygberg S; Brauner A; Chambers BJ; Wiklund C; Nilsson A
Article: IMMUNOLOGY AND CELL BIOLOGY. 2015;93(6):581-590

CD244 is expressed on dendritic cells and regulates their functions.

Georgoudaki A-M; Khodabandeh S; Puiac S; Persson CM; Larsson MK; Lind M; Hammarfjord O; Nabatti TH; Wallin RPA; Yrlid U; Rhen M; Kumar V; Chambers BJ
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2015;45(6):1794-1807

Activated NKT cells imprint NK-cell differentiation, functionality and education.

Riese P; Trittel S; May T; Cicin-Sain L; Chambers BJ; Guzmán CA
Article: JOURNAL OF IMMUNOLOGY. 2014;192(3):1313-1319

Gap junction intercellular communications regulate NK cell activation and modulate NK cytotoxic capacity.

Tittarelli A; Mendoza-Naranjo A; Farías M; Guerrero I; Ihara F; Wennerberg E; Riquelme S; Gleisner A; Kalergis A; Lundqvist A; López MN; Chambers BJ; Salazar-Onfray F
Article: SMALL. 2013;9(16):2721-2720

Biodegradation of single-walled carbon nanotubes by eosinophil peroxidase.

Andón FT; Kapralov AA; Yanamala N; Feng W; Baygan A; Chambers BJ; Hultenby K; Ye F; Toprak MS; Brandner BD; Fornara A; Klein-Seetharaman J; Kotchey GP; Star A; Shvedova AA; Fadeel B; Kagan VE
Journal article: SMALL. 2013;9(16):2720

Carbon Nanotubes: Biodegradation of Single‐Walled Carbon Nanotubes by Eosinophil Peroxidase (Small 16/2013)

Andón FT; Kapralov AA; Yanamala N; Feng W; Baygan A; Chambers BJ; Hultenby K; Ye F; Toprak MS; Brandner BD; Fornara A; Klein‐Seetharaman J; Kotchey GP; Star A; Shvedova AA; Fadeel B; Kagan VE
Article: JOURNAL OF AUTOIMMUNITY. 2013;42:62-70

AIRE expressing marginal zone dendritic cells balances adaptive immunity and T-follicular helper cell recruitment.

Lindmark E; Chen Y; Georgoudaki A-M; Dudziak D; Lindh E; Adams WC; Loré K; Winqvist O; Chambers BJ; Karlsson MCI
Article: PLOS PATHOGENS. 2013;9(7):e1003442

Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis.

Carow B; Reuschl A-K; Gavier-Widén D; Jenkins BJ; Ernst M; Yoshimura A; Chambers BJ; Rottenberg ME
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2012;75(1):54-60

The effects of hepatitis C virus core protein on functional responses in the NK cell line YTS.

Dominguez-Villar M; Garcia-Cozar FJ; Chambers BJ
Article: INFECTION AND IMMUNITY. 2011;79(8):3046-3052

Migratory activation of primary cortical microglia upon infection with Toxoplasma gondii.

Dellacasa-Lindberg I; Fuks JM; Arrighi RBG; Lambert H; Wallin RPA; Chambers BJ; Barragan A
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(8):2155-2164

Plasmacytoid dendritic cell-induced migration and activation of NK cells in vivo.

Persson CM; Chambers BJ
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2009;86(1):91-101

Heterogeneous expression of the adhesion receptor CD226 on murine NK and T cells and its function in NK-mediated killing of immature dendritic cells.

Seth S; Georgoudaki A-M; Chambers BJ; Qiu Q; Kremmer E; Maier MK; Czeloth N; Ravens I; Foerster R; Bernhardt G
Article: INFECTION AND IMMUNITY. 2009;77(3):970-976

Transmission of Toxoplasma gondii from infected dendritic cells to natural killer cells.

Persson CM; Lambert H; Vutova PP; Dellacasa-Lindberg I; Nederby J; Yagita H; Ljunggren H-G; Grandien A; Barragan A; Chambers BJ
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2008;83(1):56-63

Human cytomegalovirus-derived protein UL18 alters the phenotype and function of monocyte-derived dendritic cells.

Wagner CS; Walther-Jallow L; Buentke E; Ljunggren H-G; Achour A; Chambers BJ
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;67(1):30-36

Critical role of Qa1b in the protection of mature dendritic cells from NK cell-mediated killing.

Persson CM; Assarsson E; Vahlne G; Brodin P; Chambers BJ
Article: JOURNAL OF IMMUNOLOGY. 2007;179(12):8357-8365

Death receptor ligation or exposure to perforin trigger rapid egress of the intracellular parasite Toxoplasma gondii.

Persson EK; Agnarson AM; Lambert H; Hitziger N; Yagita H; Chambers BJ; Barragan A; Grandien A
Article: CANCER RESEARCH. 2007;67(18):8450-8455

Induction of protective CTL immunity against peptide transporter TAP-deficient tumors through dendritic cell vaccination.

Chambers B; Grufman P; Fredriksson V; Andersson K; Roseboom M; Laban S; Camps M; Wolpert EZ; Wiertz EJHJ; Offringa R; Ljunggren H-G; van Hall T
Article: JOURNAL OF IMMUNOLOGY. 2007;178(8):5018-5027

Severe defect in thymic development in an insertional mutant mouse model.

Assarsson E; Chambers BJ; Högstrand K; Berntman E; Lundmark C; Fedorova L; Imreh S; Grandien A; Cardell S; Rozell B; Ljunggren H-G
Article: JOURNAL OF IMMUNOLOGY. 2004;173(1):174-180

NK cells stimulate proliferation of T and NK cells through 2B4/CD48 interactions.

Assarsson E; Kambayashi T; Schatzle JD; Cramer SO; von Bonin A; Jensen PE; Ljunggren H-G; Chambers BJ
Article: JOURNAL OF IMMUNOLOGY. 2004;172(1):123-129

NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy.

Hayakawa Y; Screpanti V; Yagita H; Grandien A; Ljunggren H-G; Smyth MJ; Chambers BJ
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2003;58(5):493-502

Nitric oxide produced by murine dendritic cells is cytotoxic for intracellular Salmonella enterica sv. Typhimurium.

Eriksson S; Chambers BJ; Rhen M
Article: LEUKEMIA. 2003;17(10):1973-1980

Expansion of natural killer (NK) and natural killer-like T (NKT)-cell populations derived from patients with B-chronic lymphocytic leukemia (B-CLL): a potential source for cellular immunotherapy.

Guven H; Gilljam M; Chambers BJ; Ljunggren HG; Christensson B; Kimby E; Dilber MS
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2003;33(1):92-100

Natural killer cell-mediated lysis of dorsal root ganglia neurons via RAE1/NKG2D interactions.

Backström E; Chambers BJ; Ho EL; Naidenko OV; Mariotti R; Fremont DH; Yokoyama WM; Kristensson K; Ljunggren H-G
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2002;119(4):850-857

Natural killer and dendritic cell contact in lesional atopic dermatitis skin--Malassezia-influenced cell interaction.

Buentke E; Heffler LC; Wilson JL; Wallin RPA; Löfman C; Chambers BJ; Ljunggren H-G; Scheynius A
Article: JOURNAL OF NEUROVIROLOGY. 2002;8(SUPPL 1):30-31

Viral infections & autoimmune disease

Backstrom E; Chambers B; Kristensson K; Ljunggren H-G
Article: JOURNAL OF IMMUNOLOGY. 2001;167(12):6706-6710

Cutting edge: Regulation of CD8(+) T cell proliferation by 2B4/CD48 interactions.

Kambayashi T; Assarsson E; Chambers BJ; Ljunggren HG
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2001;31(11):3248-3254

IL-2 down-regulates the expression of TCR and TCR-associated surface molecules on CD8(+) T cells.

Kambayashi T; Assarsson E; Chambers BJ; Ljunggren HG
Article: HUMAN IMMUNOLOGY. 2001;62(10):1092-1098

A new method for in vitro expansion of cytotoxic human CD3-CD56+ natural killer cells.

Carlens S; Gilljam M; Chambers BJ; Aschan J; Guven H; Ljunggren HG; Christensson B; Dilber MS
Article: INFECTION AND IMMUNITY. 2001;69(9):5726-5735

In vivo activation of dendritic cells and T cells during Salmonella enterica serovar Typhimurium infection.

Yrlid U; Svensson M; Håkansson A; Chambers BJ; Ljunggren HG; Wick MJ
Article: JOURNAL OF IMMUNOLOGY. 2001;166(10):6430-6436

Anti-CTLA-4 antibody treatment triggers determinant spreading and enhances murine myasthenia gravis.

Wang HB; Shi FD; Li H; Chambers BJ; Link H; Ljunggren HG
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2001;31(5):1523-1530

Expression of the DX5 antigen on CD8+ T cells is associated with activation and subsequent cell death or memory during influenza virus infection.

Kambayashi T; Assarsson E; Chambers BJ; Ljunggren HG
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2001;31(3):869-875

Purified MHC class I molecules inhibit activated NK cells in a cell-free system in vitro.

Kambayashi T; Michaëlsson J; Fahlén L; Chambers BJ; Sentman CL; Kärre K; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 2000;165(9):4964-4969

Emergence of CD8+ T cells expressing NK cell receptors in influenza A virus-infected mice.

Kambayashi T; Assarsson E; Michaëlsson J; Berglund P; Diehl AD; Chambers BJ; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 2000;165(9):4895-4900

Direct NK cell-mediated lysis of syngenic dorsal root ganglia neurons in vitro.

Backström E; Chambers BJ; Kristensson K; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 2000;165(7):3673-3679

CD8+ T cells rapidly acquire NK1.1 and NK cell-associated molecules upon stimulation in vitro and in vivo.

Assarsson E; Kambayashi T; Sandberg JK; Hong S; Taniguchi M; Van Kaer L; Ljunggren HG; Chambers BJ
Article: INTERNATIONAL IMMUNOLOGY. 2000;12(10):1381-1388

Tumor necrosis factor receptor-1 is critically involved in the development of experimental autoimmune myasthenia gravis.

Wang HB; Li H; Shi FD; Chambers BJ; Link H; Ljunggren HG
Article: NATURE IMMUNOLOGY. 2000;1(3):234-238

Impaired immune responses and altered peptide repertoire in tapasin-deficient mice.

Garbi N; Tan P; Diehl AD; Chambers BJ; Ljunggren HG; Momburg F; Hämmerling GJ
Article: JOURNAL OF IMMUNOLOGY. 1999;163(8):4207-4212

NK cell triggering by the human costimulatory molecules CD80 and CD86.

Wilson JL; Charo J; Martín-Fontecha A; Dellabona P; Casorati G; Chambers BJ; Kiessling R; Bejarano MT; Ljunggren HG
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 1999;189(3):553-562

Natural killer cells determine development of allergen-induced eosinophilic airway inflammation in mice.

Korsgren M; Persson CG; Sundler F; Bjerke T; Hansson T; Chambers BJ; Hong S; Van Kaer L; Ljunggren HG; Korsgren O
Article: JOURNAL OF IMMUNOLOGY. 1998;161(12):6475-6479

MHC class I mosaic mice reveal insights into control of Ly49C inhibitory receptor expression in NK cells.

Andersson M; Freland S; Johansson MH; Wallin R; Sandberg JK; Chambers BJ; Christensson B; Lendahl U; Lemieux S; Salcedo M; Ljunggren HG
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1998;28(4):1315-1321

Fine tuning of natural killer cell specificity and maintenance of self tolerance in MHC class I-deficient mice.

Salcedo M; Andersson M; Lemieux S; Van Kaer L; Chambers BJ; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 1998;160(7):3163-3169

Superdominance among immunodominant H-2Kb-restricted epitopes and reversal by dendritic cell-mediated antigen delivery.

Sandberg JK; Grufman P; Wolpert EZ; Franksson L; Chambers BJ; Kärre K
Article: JOURNAL OF IMMUNOLOGY. 1998;160(2):572-579

Rejection of allogeneic and syngeneic but not MHC class I-deficient tumor grafts by MHC class I-deficient mice.

Freland S; Chambers BJ; Andersson M; Van Kaer L; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 1997;159(11):5364-5371

TAP peptide transporter-independent presentation of heat-killed Sendai virus antigen on MHC class I molecules by splenic antigen-presenting cells.

Liu T; Chambers B; Diehl AD; Van Kaer L; Jondal M; Ljunggren HG
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1997;94(21):11496-11501

Generation of CD8+ T cells specific for transporter associated with antigen processing deficient cells.

Wolpert EZ; Petersson M; Chambers BJ; Sandberg JK; Kiessling R; Ljunggren HG; Kärre K
Article: JOURNAL OF MEDICAL VIROLOGY. 1997;52(4):362-369

Spread of measles virus through axonal pathways into limbic structures in the brain of TAP1 -/- mice.

Urbanska EM; Chambers BJ; Ljunggren HG; Norrby E; Kristensson K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1997;27(1):280-288

Constitutive macropinocytosis allows TAP-dependent major histocompatibility complex class I presentation of exogenous soluble antigen by bone marrow-derived dendritic cells.

Norbury CC; Chambers BJ; Prescott AR; Ljunggren HG; Watts C
Article: IMMUNITY. 1996;5(4):311-317

Triggering of natural killer cells by the costimulatory molecule CD80 (B7-1).

Chambers BJ; Salcedo M; Ljunggren HG
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1996;26(2):288-293

TAP1-deficient mice select a CD8+ T cell repertoire that displays both diversity and peptide specificity.

Sandberg JK; Chambers BJ; Van Kaer L; Kärre K; Ljunggren HG
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Corrigendum: NATURE COMMUNICATIONS. 2022;13(1):6545

Publisher Correction: HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection.

Liu R; Muliadi V; Mou W; Li H; Yuan J; Holmberg J; Chambers BJ; Ullah N; Wurth J; Alzrigat M; Schlisio S; Carow B; Larsson LG; Rottenberg ME
Preprint: BIORXIV. 2022

Jagged1 overexpression on T cells induces thymic regulatory T cells leading to thymic involution

Kritikou JS; Sánchez-Pascual I; Muñoz-Miranda JP; Vashist N; Wagner AK; Zhang X-M; Assarsson E; Dominguez-Villar M; Yagita H; Garcia-Cozar F; Riese P; Harris RA; Ljunggren H-G; Chambers BJ
Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2022;52:29

Individuals with active and latent Tuberculosis have distinct NK cell function

Silva CS; Folkesson E; Froberg G; Chambers BJ; Lakshmikanth T; Brodin P; Bruchfeld J; Correia-Neves M; Kallenius G; Sundling C
Preprint: BIORXIV. 2021

PD-1 expression on NK cells can be related to cytokine stimulation and tissue residency

Wagner A; Kadri N; Tibbitt C; van de Ven K; Bagawath-Singh S; Oliinyk D; LeGresly E; Campbell N; Trittel S; Riese P; Sandalova T; Achour A; Kärre K; Chambers B
Preprint: BIORXIV. 2021

GABAergic signaling in human and murine NK cells upon challenge with Toxoplasma gondii

Bhandage AK; Friedrich LM; Kanatani S; Jakobsson-Björkén S; Escrig-Larena JI; Wagner AK; Chambers BJ; Barragan A
Preprint: MEDRXIV. 2021

High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19

Lourda M; Dzidic M; Hertwig L; Bergsten H; Medina LP; Kvedaraite E; Chen P; Muvva J; Gorin J-B; Cornillet M; Emgård J; Moll K; García M; Maleki K; Klingström J; Michaëlsson J; Flodström-Tullberg M; Brighenti S; Buggert M; Mjösberg J; Malmberg K-J; Sandberg J; Henter J-I; Folkesson E; Gredmark-Russ S; Sönnerborg A; Eriksson L; Rooyackers O; Aleman S; Strålin K; Ljunggren H-G; Björkström N; Svensson M; Ponzetta A; Norrby-Teglund A; Chambers B; the Karolinska KI/K COVID-19 Study Group
Preprint: BIORXIV. 2021

FOXO1 and FOXO3 cooperatively regulate innate lymphoid cell development

Luu T; Søndergaard JN; Peña-Pérez L; Kharazi S; Krstic A; Meinke S; Schmied L; Frengen N; Heshmati Y; Kierczak M; Bouderlique T; Wagner AK; Gustafsson C; Chambers B; Achour A; Kutter C; Höglund P; Månsson R; Kadri N
Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51:297

Stimulation with mycobacterial glycolipids reveals different innate immune response profiles in active and latent tuberculosis

Silva CS; Sundling C; Folkesson E; Froberg G; Nobrega C; Chambers BJ; Lakshmikanth T; Brodin P; Bruchfeld J; Nigou J; Neves MC; Kallenius G
Letter: EUROPEAN JOURNAL OF IMMUNOLOGY. 2014;44(1):307-308

To the editor: TIGIT versus CD226: hegemony or coexistence?

Georgiev H; Danisch S; Chambers BJ; Shibuya A; Förster R; Bernhardt G
Conference publication: JOURNAL OF IMMUNOLOGY. 2013;190:170.49

Gap junction intercellular communication enhances NK cell activation and cytotoxic capacity

Salazar-Onfray F; Tittarelli A; Mendoza-Naranjo A; Lopez M; Chambers B; Lundqvist A; Guerrero I
Editorial comment: IMMUNOLOGY AND CELL BIOLOGY. 2010;88(2):105-106

Unique features of NK cell development during ontogeny revealed in studies of RAG-1-deficient mice.

Chambers BJ; Ljunggren H-G
Review: JOURNAL OF IMMUNOLOGY. 2005;175(4):2045-2049

2B4/CD48-mediated regulation of lymphocyte activation and function.

Assarsson E; Kambayashi T; Persson CM; Chambers BJ; Ljunggren H-G
Published conference paper: MOLECULAR IMMUNOLOGY. 2005;42(4):419-423

2B4 co-stimulation: NK cells and their control of adaptive immune responses.

Assarsson E; Kambayashi T; Persson CM; Ljunggren H-G; Chambers BJ
Review: NANOPARTICLES FOR RATIONAL VACCINE DESIGN. 1998;230:53-61

Triggering of natural killer cell mediated cytotoxicity by costimulatory molecules.

Chambers BJ; Wilson JL; Salcedo M; Markovic K; Bejarano MT; Ljunggren HG
Review: CANCER JOURNAL. 1996;9(6):304-307

MHC class I molecules, their role in presenting peptide antigens, including tumor antigens, to cytotoxic T lymphocytes

Freland S; Chambers BJ; Ljunggren HG

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Researcher, Department of Medicine, Huddinge, Karolinska Institutet, 2011-
Researcher, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2024-2025

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Docent, Karolinska Institutet, 2008

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