Benedict Chambers

About me
Publications
CV
Public outreach and news

Research

Our group studies how immune cells interact with each other and how we can manipulate these interactions to enhance host responses to cancer and infections

Teaching

I am an award winning teacher and educate at all levels at Karolinska Institute. My areas of expertese are within immunology and infection biology.
I am also responsible for the Amgen Scholars program at the Karolinska Institutet.

Articles

Article: JOURNAL OF INFECTIOUS DISEASES. 2024;230(2):e318-e326
Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19
Strunz B; Maucourant C; Mehta A; Wan H; Du L; Sun D; Chen P; Nordlander A; Gao Y; Cornillet M; Bister J; Kvedaraite E; Christ W; Klingstrom J; Geanon D; Parke A; Ekwall-Larson A; Rivino L; MacAry PA; Aleman S; Buggert M; Ljunggren H-G; Pan-Hammarstrom Q; Lund-Johansen F; Stralin K; Bjorkstrom NK
Article: ACS NANO. 2023;17(17):17451-17467
Exploiting Mass Spectrometry to Unlock the Mechanism of Nanoparticle-Induced Inflammasome Activation
Gupta G; Kaur J; Bhattacharya K; Chambers BJ; Gazzi A; Furesi G; Rauner M; Fuoco C; Orecchioni M; Delogu LG; Haag L; Stehr JE; Thomen A; Bordes R; Malmberg P; Seisenbaeva GA; Kessler VG; Persson M; Fadeel B
Article: RESPIRATORY RESEARCH. 2023;24(1):62
Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia
Palma Medina LM; Babacic H; Dzidic M; Parke A; Garcia M; Maleki KT; Unge C; Lourda M; Kvedaraite E; Chen P; Muvva JR; Cornillet M; Emgard J; Moll K; Michaelsson J; Flodstrom-Tullberg M; Brighenti S; Buggert M; Mjosberg J; Malmberg K-JK; Sandberg J; Gredmark-Russ S; Rooyackers O; Svensson MJ; Chambers BI; Eriksson L; Pernemalm MK; Bjorkstrom N; Aleman S; Ljunggren H-G; Klingstrom J; Stralin K; Norrby-Teglund A
Article: ISCIENCE. 2023;26(2):106071
Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment
Fernandes S; Srivastava N; Pedicone C; Sudan R; Luke EA; Dungan OM; Pacherille A; Meyer ST; Dormann S; Schurmans S; Chambers BJ; Chisholm JD; Kerr WG
Journal article: ACS NANO. 2023
Exploiting Mass Spectrometry to Unlock the Mechanism of Nanoparticle-Induced Inflammasome Activation
Gupta G; Kaur J; Bhattacharya K; Chambers BJ; Gazzi A; Furesi G; Rauner M; Fuoco C; Orecchioni M; Delogu LG; Haag L; Stehr JE; Thomen A; Bordes R; Malmberg P; Seisenbaeva GA; Kessler VG; Persson M; Fadeel B
Article: ISCIENCE. 2022;25(10):105137
PD-1 expression on mouse intratumoral NK cells and its effects on NK cell phenotype
Wagner AK; Kadri N; Tibbitt C; van de Ven K; Bagawath-Singh S; Oliinyk D; LeGresley E; Campbell N; Trittel S; Riese P; Ribacke U; Sandalova T; Achour A; Karre K; Chambers BJ
Article: NATURE COMMUNICATIONS. 2022;13(1):5093
HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection
Liu R; Muliadi V; Mou W; Li H; Yuan J; Holmberg J; Chambers BJ; Ullah N; Wurth J; Alzrigat M; Schlisio S; Carow B; Larsson LG; Rottenberg ME
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2022;96(1):e13195
The Karolinska KI/K COVID-19 immune atlas: An open resource for immunological research and educational purposes
Ljunggren H-G; Heggernes Ask E; Cornillet Jeannin M; Strunz B; Chen P; Rao Muvva J; Akber M; Buggert M; Chambers BJ; Cuapio Gomez A; Dzidic M; Filipovic I; Flodstrom-Tullberg M; Garcia M; Gorin J-B; Gredmark-Russ S; Hertwig L; Klingstrom J; Kokkinou E; Kvedaraite E; Lourda M; Mjosberg J; Maucourant C; Norrby-Teglund A; Palma Medina LM; Parrot T; Perez-Potti A; Ponzetta A; Ringqvist E; Rivera-Ballesteros O; Rooyackers O; Sandberg JK; Sandberg JT; Sekine T; Svensson M; Varnaite R; Wullimann D; Eriksson LI; Aleman S; Malmberg K-J; Stralin K; Bjorkstrom NK
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2022;52(3):503-510
COVID-19-specific metabolic imprint yields insights into multiorgan system perturbations
Cornillet M; Strunz B; Rooyackers O; Ponzetta A; Chen P; Muvva JR; Akber M; Buggert M; Chambers BJ; Dzidic M; Filipovic I; Gorin J-B; Gredmark-Russ S; Hertwig L; Klingstrom J; Kokkinou E; Kvedaraite E; Lourda M; Mjosberg J; Maucourant C; Norrby-Teglund A; Parrot T; Perez-Potti A; Rivera-Ballesteros O; Sandberg JK; Sandberg JT; Sekine T; Svensson M; Varnaite R; Eriksson LI; Aleman S; Stralin K; Ljunggren H-G; Bjorkstrom NK
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:854312
FOXO1 and FOXO3 Cooperatively Regulate Innate Lymphoid Cell Development
Luu TT; Sondergaard JN; Pena-Perez L; Kharazi S; Krstic A; Meinke S; Schmied L; Frengen N; Heshmati Y; Kierczak M; Bouderlique T; Wagner AK; Gustafsson C; Chambers BJ; Achour A; Kutter C; Hoglund P; Mansson R; Kadri N
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(40):e2109123118
High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of in COVID-19
Lourda M; Dzidic M; Hertwig L; Bergsten H; Medina LMP; Sinha I; Kvedaraite E; Chen P; Muvva JR; Gorin J-B; Cornillet M; Emgard J; Moll K; Garcia M; Maleki KT; Klingstrom J; Michaelsson J; Flodstrom-Tullberg M; Brighenti S; Buggert M; Mjosberg J; Malmberg K-J; Sandberg JK; Henter J-I; Folkesson E; Gredmark-Russ S; Sonnerborg A; Eriksson LI; Rooyackers O; Aleman S; Stralin K; Ljunggren H-G; Bjorkstrom NK; Svensson M; Ponzetta A; Norrby-Teglund A; Chambers BJ
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2021;110(4):617-628
GABAergic signaling in human and murine NK cells upon challenge with Toxoplasma gondii
Bhandage AK; Friedrich LM; Kanatani S; Jakobsson-Bjorken S; Escrig-Larena JI; Wagner AK; Chambers BJ; Barragan A
Article: JOURNAL OF CELL SCIENCE. 2021;134(11):jcs257428
The murine cytomegalovirus immunoevasin gp40/m152 inhibits NKG2D receptor RAE-1γ by intracellular retention and cell surface masking
Lis N; Hein Z; Ghanwat SS; Ramnarayan VR; Chambers BJ; Springer S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(6):e2018587118
Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity
Kvedaraite E; Hertwig L; Sinha I; Ponzetta A; Myrberg IH; Lourda M; Dzidic M; Akber M; Klingstrom J; Folkesson E; Muvva JR; Chen P; Gredmark-Russ S; Brighenti S; Norrby-Teglund A; Eriksson LI; Rooyackers O; Aleman S; Stralin K; Ljunggren H-G; Ginhoux F; Bjorkstrom NK; Henter J-I; Svensson M
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:727300
High Dimensional Immune Profiling Reveals Different Response Patterns in Active and Latent Tuberculosis Following Stimulation With Mycobacterial Glycolipids
Silva CS; Sundling C; Folkesson E; Froberg G; Nobrega C; Canto-Gomes J; Chambers BJ; Lakshmikanth T; Brodin P; Bruchfeld J; Nigou J; Correia-Neves M; Kallenius G
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1306
SARS-CoV-2-specific humoral and cellular immunity persists through 9 months irrespective of COVID-19 severity at hospitalisation
Sandberg JT; Varnaite R; Christ W; Chen P; Muvva JR; Maleki KT; Garcia M; Dzidic M; Folkesson E; Skagerberg M; Ahlen G; Frelin L; Sallberg M; Eriksson LI; Rooyackers O; Sonnerborg A; Buggert M; Bjorkstrom NK; Aleman S; Stralin K; Klingstrom J; Ljunggren H-G; Blom K; Gredmark-Russ S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(50):32005-32016
Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells
Eisinger S; Sarhan D; Boura VF; Ibarlucea-Benitez I; Tyystjarvi S; Oliynyk G; Arsenian-Henriksson M; Lane D; Wikstrom SL; Kiessling R; Virgilio T; Gonzalez SF; Kaczynska D; Kanatani S; Daskalaki E; Wheelock CE; Sedimbi S; Chambers BJ; Ravetch JV; Karlsson MCI
Article: CELL. 2020;183(1):158-168.e14
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
Sekine T; Perez-Potti A; Rivera-Ballesteros O; Stralin K; Gorin J-B; Olsson A; Llewellyn-Lacey S; Kamal H; Bogdanovic G; Muschiol S; Wullimann DJ; Kammann T; Emgard J; Parrot T; Folkesson E; Rooyackers O; Eriksson LI; Henter J-I; Sonnerborg A; Allander T; Albert J; Nielsen M; Klingstrom J; Gredmark-Russ S; Bjorkstrom NK; Sandberg JK; Price DA; Ljunggren H-G; Aleman S; Buggert M
Article: SCIENCE IMMUNOLOGY. 2020;5(51):eabe1670
MAIT cell activation and dynamics associated with COVID-19 disease severity
Parrot T; Gorin J-B; Ponzetta A; Maleki KT; Kammann T; Emgard J; Perez-Potti A; Sekine T; Rivera-Ballesteros O; Gredmark-Russ S; Rooyackers O; Folkesson E; Eriksson LI; Norrby-Teglund A; Ljunggren H-G; Bjorkstrom NK; Aleman S; Buggert M; Klingstrom J; Stralin K; Sandberg JK
Article: SCIENCE IMMUNOLOGY. 2020;5(50):eabd6832
Natural killer cell immunotypes related to COVID-19 disease severity
Maucourant C; Filipovic I; Ponzetta A; Aleman S; Cornillet M; Hertwig L; Strunz B; Lentini A; Reinius B; Brownlie D; Cuapio A; Ask EH; Hull RM; Haroun-Izquierdo A; Schaffer M; Klingstrom J; Folkesson E; Buggert M; Sandberg JK; Eriksson LI; Rooyackers O; Ljunggren H-G; Malmberg K-J; Michaelsson J; Marquardt N; Hammer Q; Stralin K; Bjorkstrom NK
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2020;50(4):494-504
IL-15 and CD155 expression regulate LAT expression in murine DNAM1⁺ NK cells, enhancing their effectors functions
Luu TT; Wagner AK; Schmied L; Meinke S; Freund JE; Kambayashi T; Ravens I; Achour A; Bernhardt G; Chambers BJ; Hoglund P; Kadri N
Article: IMMUNITY, INFLAMMATION AND DISEASE. 2020;8(1):8-23
PD-1 expression affects cytokine production by ILC2 and is influenced by peroxisome proliferator-activated receptor-γ
Batyrova B; Luwaert F; Maravelia P; Miyabayashi Y; Vashist N; Stark JM; Soori SY; Tibbitt CA; Riese P; Coquet JM; Chambers BJ
Article: SCIENTIFIC REPORTS. 2019;9(1):16362
Key features and homing properties of NK cells in the liver are shaped by activated iNKT cells
Trittel S; Chambers BJ; Heise U; Guzman CA; Riese P
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1849
Invariant NKT Cell-Mediated Modulation of ILC1s as a Tool for Mucosal Immune Intervention
Trittel S; Vashist N; Ebensen T; Chambers BJ; Guzman CA; Riese P
Article: CANCER IMMUNOLOGY RESEARCH. 2018;6(11):1417-1425
Cripto-1 Plasmid DNA Vaccination Targets Metastasis and Cancer Stem Cells in Murine Mammary Carcinoma
Witt K; Ligtenberg MA; Conti L; Lanzardo S; Ruiu R; Wallmann T; Tufvesson-Stiller H; Chambers BJ; Rolny C; Lladser A; Lundqvist A; Cavallo F; Kiessling R
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:505
Influenza-Activated ILC1s Contribute to Antiviral Immunity Partially Influenced by Differential GITR Expression
Vashist N; Trittel S; Ebensen T; Chambers BJ; Guzman CA; Riese P
Article: PLOS PATHOGENS. 2017;13(12):e1006739
Voltage-dependent calcium channel signaling mediates GABA_A receptor-induced migratory activation of dendritic cells infected by Toxoplasma gondii
Kanatani S; Fuks JM; Olafsson EB; Westermark L; Chambers B; Varas-Godoy M; Uhlen P; Barragan A
Article: INFECTION AND IMMUNITY. 2017;85(10):e00069-e00017
Downmodulation of Effector Functions in NK Cells upon Toxoplasma gondii Infection
Sultana MA; Du A; Carow B; Angbjar CM; Weidner JM; Kanatani S; Fuks JM; Muliaditan T; James J; Mansfield IO; Campbell TM; Liu L; Kadri N; Lambert H; Barragan A; Chambers BJ
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(3):135-142
The Abl-1 Kinase is Dispensable for NK Cell Inhibitory Signalling and is not Involved in Murine NK Cell Education
Ganesan S; Luu TT; Chambers BJ; Meinke S; Brodin P; Vivier E; Wetzel DM; Koleske AJ; Kadri N; Hoglund P
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;85(6):417-424
TLR-Stimulated Eosinophils Mediate Recruitment and Activation of NK Cells In Vivo
O'Flaherty SM; Sutummaporn K; Haggtoft WL; Worrall AP; Rizzo M; Braniste V; Hoglund P; Kadri N; Chambers BJ
Article: NATURE COMMUNICATIONS. 2017;8:15627
Expression of CD226 is associated to but not required for NK cell education
Wagner AK; Kadri N; Snall J; Brodin P; Gilfillan S; Colonna M; Bernhardt GN; Hoglund P; Karre K; Chambers BJ
Article: SCIENCE IMMUNOLOGY. 2017;2(9):eaal5196
PPAR-γ promotes type 2 immune responses in allergy and nematode infection
Chen T; Tibbitt CA; Feng X; Stark JM; Rohrbeck L; Rausch L; Sedimbi SK; Karlsson MCI; Lambrecht BN; Hedestam GBK; Hendriks RW; Chambers BJ; Nylen S; Coquet JM
Article: SCIENTIFIC REPORTS. 2016;6:37996
Independent control of natural killer cell responsiveness and homeostasis at steady-state by CD11c+dendritic cells
Thuy TL; Ganesan S; Wagner AK; Sarhan D; Meinke S; Garbi N; Haemmerling G; Alici E; Karre K; Chambers BJ; Hoglund P; Kadri N
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2016;100(4):781-789
Sensitivity of dendritic cells to NK-mediated lysis depends on the inflammatory environment and is modulated by CD54/CD226-driven interactions
Smith LE; Olszewski MA; Georgoudaki A-M; Wagner AK; Hagglof T; Karlsson MCI; Dominguez-Villar M; Garcia-Cozar F; Mueller S; Ravens I; Bernhardt G; Chambers BJ
Article: ACTA PAEDIATRICA, INTERNATIONAL JOURNAL OF PAEDIATRICS. 2016;105(8):979-982
A ten-year retrospective case series of glucocorticoid treatment of bacterial meningitis in children
Ygberg S; Brauner A; Chambers BJ; Wiklund C; Nilsson A
Article: IMMUNOLOGY AND CELL BIOLOGY. 2015;93(6):581-590
CD244 is expressed on dendritic cells and regulates their functions
Georgoudaki A-M; Khodabandeh S; Puiac S; Persson CM; Larsson MK; Lind M; Hammarfjord O; Nabatti TH; Wallin RPA; Yrlid U; Rhen M; Kumar V; Chambers BJ
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2015;45(6):1794-1807
Activated NKT cells imprint NK-cell differentiation, functionality and education
Riese P; Trittel S; May T; Cicin-Sain L; Chambers BJ; Guzman CA
Article: JOURNAL OF IMMUNOLOGY. 2014;192(3):1313-1319
Gap Junction Intercellular Communications Regulate NK Cell Activation and Modulate NK Cytotoxic Capacity
Tittarelli A; Mendoza-Naranjo A; Farias M; Guerrero I; Ihara F; Wennerberg E; Riquelme S; Gleisner A; Kalergis A; Lundqvist A; Lopez MN; Chambers BJ; Salazar-Onfray F
Journal article: SMALL. 2013;9(16):2720
Carbon Nanotubes: Biodegradation of Single‐Walled Carbon Nanotubes by Eosinophil Peroxidase (Small 16/2013)
Andón FT; Kapralov AA; Yanamala N; Feng W; Baygan A; Chambers BJ; Hultenby K; Ye F; Toprak MS; Brandner BD; Fornara A; Klein‐Seetharaman J; Kotchey GP; Star A; Shvedova AA; Fadeel B; Kagan VE
Article: SMALL. 2013;9(16):2721-2720
Biodegradation of Single-Walled Carbon Nanotubes by Eosinophil Peroxidase
Andon FT; Kapralov AA; Yanamala N; Feng W; Baygan A; Chambers BJ; Hultenby K; Ye F; Toprak MS; Brandner BD; Fornara A; Klein-Seetharaman J; Kotchey GP; Star A; Shvedova AA; Fadeel B; Kagan VE
Article: JOURNAL OF AUTOIMMUNITY. 2013;42:62-70
AIRE expressing marginal zone dendritic cells balances adaptive immunity and T-follicular helper cell recruitment
Lindmark E; Chen Y; Georgoudaki A-M; Dudziak D; Lindh E; Adams WC; Lore K; Winqvist O; Chambers BJ; Karlsson MCI
Article: PLOS PATHOGENS. 2013;9(7):e1003442
Critical and Independent Role for SOCS3 in Either Myeloid or T Cells in Resistance to Mycobacterium tuberculosis
Carow B; Reuschl A-K; Gavier-Widen D; Jenkins BJ; Ernst M; Yoshimura A; Chambers BJ; Rottenberg ME
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2012;75(1):54-60
The Effects of Hepatitis C Virus Core Protein on Functional Responses in the NK Cell Line YTS
Dominguez-Villar M; Garcia-Cozar FJ; Chambers BJ
Article: INFECTION AND IMMUNITY. 2011;79(8):3046-3052
Migratory Activation of Primary Cortical Microglia upon Infection with Toxoplasma gondii
Dellacasa-Lindberg I; Fuks JM; Arrighi RBG; Lambert H; Wallin RPA; Chambers BJ; Barragan A
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(8):2155-2164
Plasmacytoid dendritic cell-induced migration and activation of NK cells in vivo
Persson CM; Chambers BJ
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2009;86(1):91-101
Heterogeneous expression of the adhesion receptor CD226 on murine NK and T cells and its function in NK-mediated killing of immature dendritic cells
Seth S; Georgoudaki A-M; Chambers BJ; Qiu Q; Kremmer E; Maier MK; Czeloth N; Ravens I; Foerster R; Bernhardt G
Article: INFECTION AND IMMUNITY. 2009;77(3):970-976
Transmission of Toxoplasma gondii from Infected Dendritic Cells to Natural Killer Cells
Persson CM; Lambert H; Vutova PP; Dellacasa-Lindberg I; Nederby J; Yagita H; Ljunggren H-G; Grandien A; Barragan A; Chambers BJ
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2008;83(1):56-63
Human cytomegalovirus-derived protein UL18 alters the phenotype and function of monocyte-derived dendritic cells
Wagner CS; Walther-Jallow L; Buentke E; Ljunggren H-G; Achour A; Chambers BJ
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;67(1):30-36
Critical role of Qa1^b in the protection of mature dendritic cells from NK cell-mediated killing
Persson CM; Assarsson E; Vahlne G; Brodin P; Chambers BJ
Article: JOURNAL OF IMMUNOLOGY. 2007;179(12):8357-8365
Death receptor ligation or exposure to perforin trigger rapid egress of the intracellular parasite Toxoplasma gondii
Persson EK; Agnarson AM; Lambert H; Hitziger N; Yagita H; Chambers BJ; Barragan A; Grandien A
Article: CANCER RESEARCH. 2007;67(18):8450-8455
Induction of protective CTL immunity against peptide transporter TAP-deficient tumors through dendritic cell vaccination
Chambers B; Grufman P; Fredriksson V; Andersson K; Roseboom M; Laban S; Camps M; Wolpert EZ; Wiertz EJHJ; Offringa R; Ljunggren H-G; van Hall T
Article: JOURNAL OF IMMUNOLOGY. 2007;178(8):5018-5027
Severe defect in thymic development in an insertional mutant mouse model
Assarsson E; Chambers BJ; Hogstrand K; Berntman E; Lundmark C; Fedorova L; Imreh S; Grandien A; Cardell S; Rozell B; Ljunggren H-G
Article: JOURNAL OF IMMUNOLOGY. 2004;173(1):174-180
NK cells stimulate proliferation of T and NK cells through 2B4/CD48 interactions
Assarsson E; Kambayashi T; Schatzle JD; Cramer SO; von Bonin A; Jensen PE; Ljunggren HG; Chambers BJ
Article: JOURNAL OF IMMUNOLOGY. 2004;172(1):123-129
NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy
Hayakawa Y; Screpanti V; Yagita H; Grandien A; Ljunggren HG; Smyth MJ; Chambers BJ
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2003;58(5):493-502
Nitric oxide produced by murine dendritic cells is cytotoxic for intracellular Salmonella enterica sv. Typhimurium
Eriksson S; Chambers BJ; Rhen M
Article: LEUKEMIA. 2003;17(10):1973-1980
Expansion of natural killer (NK) and natural killer-like T (NKT)-cell populations derived from patients with B-chronic lymphocytic leukemia (B-CLL): a potential source for cellular immunotherapy
Guven H; Gilljam M; Chambers BJ; Ljunggren HG; Christensson B; Kimby E; Dilber MS
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2003;33(1):92-100
Natural killer cell-mediated lysis of dorsal root ganglia neurons via RAE1/NKG2D interactions
Backström E; Chambers BJ; Ho EL; Naidenko OV; Mariotti R; Fremont DH; Yokoyama WM; Kristensson K; Ljunggren HG
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2002;119(4):850-857
Natural killer and dendritic cell contact in lesional atopic dermatitis skin -: Malassezia-influenced cell interaction
Buentke E; Heffler LC; Wilson JL; Wallin RPA; Löfman C; Chambers BJ; Ljunggren HG; Scheynius A
Article: JOURNAL OF NEUROVIROLOGY. 2002;8(SUPPL 1):30-31
Viral infections & autoimmune disease
Backstrom E; Chambers B; Kristensson K; Ljunggren H-G
Article: JOURNAL OF IMMUNOLOGY. 2001;167(12):6706-6710
Cutting edge:: Regulation of CD8⁺ T cell proliferation by 2B4/CD48 interactions
Kambayashi T; Assarsson E; Chambers BJ; Ljunggren HG
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2001;31(11):3248-3254
IL-2 down-regulates the expression of TCR and TCR-associated surface molecules on CD8⁺ T cells
Kambayashi T; Assarsson E; Chambers BJ; Ljunggren HG
Article: HUMAN IMMUNOLOGY. 2001;62(10):1092-1098
A new method for in vitro expansion of cytotoxic human CD3^-CD56⁺ natural killer cells
Carlens S; Gilljam M; Chambers BJ; Aschan J; Guven H; Ljunggren HG; Christensson B; Dilber MS
Article: INFECTION AND IMMUNITY. 2001;69(9):5726-5735
In vivo activation of dendritic cells and T cells during Salmonella enterica serovar typhimurium infection
Yrlid U; Svensson M; Håkansson A; Chambers BJ; Ljunggren HG; Wick MJ
Article: JOURNAL OF IMMUNOLOGY. 2001;166(10):6430-6436
Anti-CTLA-4 antibody treatment triggers determinant spreading and enhances murine myasthenia gravis
Wang HB; Shi FD; Li HL; Chambers BJ; Link H; Ljunggren HG
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2001;31(5):1523-1530
Expression of the DX5 antigen on CD8⁺ T cells is associated with activation and subsequent cell death or memory during influenza virus infection
Kambayashi T; Assarsson E; Chambers BJ; Ljunggren HG
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2001;31(3):869-875
Purified MHC class I molecules inhibit activated NK cells in a cell-free system in vitro
Kambayashi T; Michaëlsson J; Fahlén L; Chambers BJ; Sentman CL; Kärre K; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 2000;165(9):4964-4969
Emergence of CD8⁺ T cells expressing NK cell receptors in influenza A virus-infected mice
Kambayashi T; Assarsson E; Michaëlsson J; Berglund P; Diehl AP; Chambers BJ; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 2000;165(9):4895-4900
Direct NK cell-mediated lysis of syngenic dorsal root ganglia neurons in vitro
Backström E; Chambers BJ; Kristensson K; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 2000;165(7):3673-3679
CD8⁺ T cells rapidly acquire NK1.1 and NK cell-associated molecules upon stimulation in vitro and in vivo
Assarsson E; Kambayashi T; Sandberg JK; Hong S; Taniguchi M; Van Kaer L; Ljunggren HG; Chambers BJ
Article: INTERNATIONAL IMMUNOLOGY. 2000;12(10):1381-1388
Tumor necrosis factor receptor-1 is critically involved in the development of experimental autoimmune myasthenia gravis
Wang HB; Li H; Shi FD; Chambers BJ; Link H; Ljunggren HG
Article: NATURE IMMUNOLOGY. 2000;1(3):234-238
Impaired immune responses and altered peptide repertoire in tapasin-deficient mice
Garbi N; Tan P; Diehl AD; Chambers BJ; Ljunggren HG; Momburg F; Hämmerling GJ
Article: JOURNAL OF IMMUNOLOGY. 1999;163(8):4207-4212
NK cell triggering by the human costimulatory molecules CD80 and CD86
Wilson JL; Charo J; Martín-Fontecha A; Dellabona P; Casorati G; Chambers BJ; Kiessling R; Bejarano MT; Ljunggren HG
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 1999;189(3):553-562
Natural killer cells determine development of allergen-induced eosinophilic airway inflammation in mice
Korsgren M; Persson CGA; Sundler F; Bjerke T; Hansson T; Chambers BJ; Hong SM; Van Kaer L; Ljunggren HG; Korsgren O
Article: JOURNAL OF IMMUNOLOGY. 1998;161(12):6475-6479
MHC class I mosaic mice reveal insights into control of Ly49C inhibitory receptor expression in NK cells
Andersson M; Freland S; Johansson MH; Wallin R; Sandberg JK; Chambers BJ; Christensson B; Lendahl U; Lemieux S; Salcedo M; Ljunggren HG
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1998;28(4):1315-1321
Fine tuning of natural killer cell specificity and maintenance of self tolerance in MHC class I-deficient mice
Salcedo M; Andersson M; Lemieux S; Van Kaer L; Chambers BJ; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 1998;160(7):3163-3169
Superdominance among immunodominant H-2K^b-restricted epitopes and reversal by dendritic cell-mediated antigen delivery
Sandberg JK; Grufman P; Wolpert EZ; Franksson L; Chambers BJ; Kärre K
Article: JOURNAL OF IMMUNOLOGY. 1998;160(2):572-579
Rejection of allogeneic and syngeneic but not MHC class I-deficient tumor grafts by MHC class I-deficient mice
Freland S; Chambers BJ; Andersson M; Van Kaer L; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 1997;159(11):5364-5371
TAP peptide transporter-independent presentation of heat-killed Sendai virus antigen on MHC class I molecules by splenic antigen-presenting cells
Liu TM; Chambers B; Diehl AD; Van Kaer L; Jondal M; Ljunggren HG
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1997;94(21):11496-11501
Generation of CD8(+) T cells specific for transporter associated with antigen processing deficient cells
Wolpert EZ; Petersson M; Chambers BJ; Sandberg JK; Kiessling R; Ljunggren HG; Karre K
Article: JOURNAL OF MEDICAL VIROLOGY. 1997;52(4):362-369
Spread of measles virus through axonal pathways into limbic structures in the brain of TAP1 -/- mice
Urbanska EM; Chambers BJ; Ljunggren HG; Norrby E; Kristensson K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1997;27(1):280-288
Constitutive macropinocytosis allows TAP-dependent major histocompatibility complex class I presentation of exogenous soluble antigen by bone marrow-derived dendritic cells
Norbury CC; Chambers BJ; Prescott AR; Ljunggren HG; Watts C
Article: IMMUNITY. 1996;5(4):311-317
Triggering of natural killer cells by the costimulatory molecule CD80 (B7-1)
Chambers BJ; Salcedo M; Ljunggren HG
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1996;26(2):288-293
TAP1-deficient mice select a CD8(+) T cell repertoire that displays both diversity and peptide specificity
Sandberg JK; Chambers BJ; VanKaer L; Karre K; Ljunggren HG
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Corrigendum: NATURE COMMUNICATIONS. 2022;13(1):6545
HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection (vol 13, 5093, 2022)
Liu R; Muliadi V; Mou W; Li H; Yuan J; Holmberg J; Chambers BJ; Ullah N; Wurth J; Alzrigat M; Schlisio S; Carow B; Larsson LG; Rottenberg ME
Preprint: BIORXIV. 2022
Jagged1 overexpression on T cells induces thymic regulatory T cells leading to thymic involution
Kritikou JS; Sánchez-Pascual I; Muñoz-Miranda JP; Vashist N; Wagner AK; Zhang X-M; Assarsson E; Dominguez-Villar M; Yagita H; Garcia-Cozar F; Riese P; Harris RA; Ljunggren H-G; Chambers BJ
Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2022;52:29
Individuals with active and latent Tuberculosis have distinct NK cell function
Silva CS; Folkesson E; Froberg G; Chambers BJ; Lakshmikanth T; Brodin P; Bruchfeld J; Correia-Neves M; Kallenius G; Sundling C
Preprint: BIORXIV. 2021
PD-1 expression on NK cells can be related to cytokine stimulation and tissue residency
Wagner A; Kadri N; Tibbitt C; van de Ven K; Bagawath-Singh S; Oliinyk D; LeGresly E; Campbell N; Trittel S; Riese P; Sandalova T; Achour A; Kärre K; Chambers B
Preprint: BIORXIV. 2021
GABAergic signaling in human and murine NK cells upon challenge with Toxoplasma gondii
Bhandage AK; Friedrich LM; Kanatani S; Jakobsson-Björkén S; Escrig-Larena JI; Wagner AK; Chambers BJ; Barragan A
Preprint: MEDRXIV. 2021
High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19
Lourda M; Dzidic M; Hertwig L; Bergsten H; Medina LP; Kvedaraite E; Chen P; Muvva J; Gorin J-B; Cornillet M; Emgård J; Moll K; García M; Maleki K; Klingström J; Michaëlsson J; Flodström-Tullberg M; Brighenti S; Buggert M; Mjösberg J; Malmberg K-J; Sandberg J; Henter J-I; Folkesson E; Gredmark-Russ S; Sönnerborg A; Eriksson L; Rooyackers O; Aleman S; Strålin K; Ljunggren H-G; Björkström N; Svensson M; Ponzetta A; Norrby-Teglund A; Chambers B; the Karolinska KI/K COVID-19 Study Group
Preprint: BIORXIV. 2021
FOXO1 and FOXO3 cooperatively regulate innate lymphoid cell development
Luu T; Søndergaard JN; Peña-Pérez L; Kharazi S; Krstic A; Meinke S; Schmied L; Frengen N; Heshmati Y; Kierczak M; Bouderlique T; Wagner AK; Gustafsson C; Chambers B; Achour A; Kutter C; Höglund P; Månsson R; Kadri N
Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51:297
Stimulation with mycobacterial glycolipids reveals different innate immune response profiles in active and latent tuberculosis
Silva CS; Sundling C; Folkesson E; Froberg G; Nobrega C; Chambers BJ; Lakshmikanth T; Brodin P; Bruchfeld J; Nigou J; Neves MC; Kallenius G
Letter: EUROPEAN JOURNAL OF IMMUNOLOGY. 2014;44(1):307-308
TIGIT versus CD226: Hegemony or coexistence?
Georgiev H; Danisch S; Chambers BJ; Shibuya A; Foerster R; Bernhardt G
Conference publication: JOURNAL OF IMMUNOLOGY. 2013;190:170.49
Gap junction intercellular communication enhances NK cell activation and cytotoxic capacity
Salazar-Onfray F; Tittarelli A; Mendoza-Naranjo A; Lopez M; Chambers B; Lundqvist A; Guerrero I
Editorial comment: IMMUNOLOGY AND CELL BIOLOGY. 2010;88(2):105-106
Unique features of NK cell development during ontogeny revealed in studies of RAG-1-deficient mice
Chambers BJ; Ljunggren H-G
Review: JOURNAL OF IMMUNOLOGY. 2005;175(4):2045-2049
2B4/CD48-mediated regulation of lymphocyte activation and function
Assarsson E; Kambayashi T; Persson CM; Chambers BJ; Ljunggren HG
Published conference paper: MOLECULAR IMMUNOLOGY. 2005;42(4):419-423
2B4 co-stimulation: NK cells and their control of adaptive immune responses
Assarsson E; Kambayashi T; Persson CM; Ljunggren HG; Chambers BJ
Review: CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY. 1998;230:53-61
Triggering of natural killer cell mediated cytotoxicity by costimulatory molecules
Chambers BJ; Wilson JL; Salcedo M; Markovic K; Bejarano MT; Ljunggren HG
Review: CANCER JOURNAL. 1996;9(6):304-307
MHC class I molecules, their role in presenting peptide antigens, including tumor antigens, to cytotoxic T lymphocytes
Freland S; Chambers BJ; Ljunggren HG

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Researcher, Department of Medicine, Huddinge, Karolinska Institutet, 2011-
Researcher, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2024-2025

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Docent, Karolinska Institutet, 2008

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