Anna Norrby-Teglund

About me
Publications
CV
Public outreach and news

About me

Professor of Medical Microbial Pathogenesis and Head of Unit at the Center for Infectious Medicine (CIM) at the Department of Medicine, Huddinge since 2008.

Research

Research in medical microbial pathogenesis study how microbes, primarily bacteria, cause disease. The research covers the interaction between bacteria and the infected person's immune system, how the disease can be diagnosed and how it should be treated.

Anna Norrby-Teglund research focuses on severe invasive bacterial infections, e.g. sepsis, septic shock and soft tissue infections, particularly infections caused by group A streptococcus and Staphylococcus aureus.

Articles

Article: JOURNAL OF BIOMEDICAL SCIENCE. 2024;31(1):26
Reduced interleukin-18 secretion by human monocytic cells in response to infections with hyper-virulent Streptococcus pyogenes
Toelken LA; Paulikat AD; Jachmann LH; Reder A; Salazar MG; Medina LMP; Michalik S; Voelker U; Svensson M; Norrby-Teglund A; Hoff KJ; Lammers M; Siemens N
Article: JOURNAL OF IMMUNOLOGY. 2024;212(3):389-396
Dynamic MAIT Cell Recovery after Severe COVID-19 Is Transient with Signs of Heterogeneous Functional Anomalies
Kammann T; Gorin J-B; Parrot T; Gao Y; Ponzetta A; Emgard J; Maleki KT; Sekine T; Rivera-Ballesteros O; Gredmark-Russ S; Rooyackers O; Skagerberg M; Eriksson LI; Norrby-Teglund A; Mak JYW; Fairlie DP; Bjorkstrom NK; Klingstrom J; Ljunggren H-G; Aleman S; Buggert M; Stralin K; Sandberg JK
Article: PHARMACEUTICS. 2024;16(1):117
Antibiotics against Pseudomonas aeruginosa on Human Skin Cell Lines: Determination of the Highest Non-Cytotoxic Concentrations with Antibiofilm Capacity for Wound Healing Strategies
Quinones-Vico MI; Fernandez-Gonzalez A; Ubago-Rodriguez A; Moll K; Norrby-Teglund A; Svensson M; Gutierrez-Fernandez J; Torres JM; Arias-Santiago S
Article: JOURNAL OF BIOMEDICAL SCIENCE. 2023;30(1):52
Neutrophil-derived reactive agents induce a transient SpeB negative phenotype in Streptococcus pyogenes
Shumba P; Sura T; Moll K; Chakrakodi B; Toelken L; Hossmann J; Hoff K; Hyldegaard O; Nekludov M; Svensson M; Arnell P; Skrede S; Norrby-Teglund A; Siemens N
Article: NATURE COMMUNICATIONS. 2023;14(1):4008
Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability
Movert E; Bolarin JS; Valfridsson C; Velarde J; Skrede S; Nekludov M; Hyldegaard O; Arnell P; Svensson M; Norrby-Teglund A; Cho KH; Elhaik E; Wessels MR; Raberg L; Carlsson F
Article: CLINICAL IMMUNOLOGY. 2023;249:109276
Systemic immune activation profiles in streptococcal necrotizing soft tissue infections: A prospective multicenter study
Rath E; Medina LMP; Jahagirdar S; Mosevoll KA; Damas JK; Madsen MB; Svensson M; Hyldegaard O; dos Santos VAPM; Saccenti E; Norrby-Teglund A; Skrede S; Bruun T
Article: RESPIRATORY RESEARCH. 2023;24(1):62
Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia
Palma Medina LM; Babacic H; Dzidic M; Parke A; Garcia M; Maleki KT; Unge C; Lourda M; Kvedaraite E; Chen P; Muvva JR; Cornillet M; Emgard J; Moll K; Michaelsson J; Flodstrom-Tullberg M; Brighenti S; Buggert M; Mjosberg J; Malmberg K-JK; Sandberg J; Gredmark-Russ S; Rooyackers O; Svensson MJ; Chambers BI; Eriksson L; Pernemalm MK; Bjorkstrom N; Aleman S; Ljunggren H-G; Klingstrom J; Stralin K; Norrby-Teglund A
Article: OPEN FORUM INFECTIOUS DISEASES. 2022;9(11):ofac571
Clinical Characteristics and Histopathology in Suspected Necrotizing Soft Tissue Infections
Gundersen IM; Berget E; Haugland HK; Bruun T; Almeland SK; Assmus J; Rath E; Norrby-Teglund A; Skrede S; Mosevoll KA
Article: INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS. 2022;167:104878
Decision support system and outcome prediction in a cohort of patients with necrotizing soft-tissue infections
Katz S; Suijker J; Hardt C; Madsen MB; Meij-de Vries A; Pijpe A; Skrede S; Hyldegaard O; Solligard E; Norrby-Teglund A; Saccenti E; dos Santos VAPM
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2022;96(1):e13195
The Karolinska KI/K COVID-19 immune atlas: An open resource for immunological research and educational purposes
Ljunggren H-G; Heggernes Ask E; Cornillet Jeannin M; Strunz B; Chen P; Rao Muvva J; Akber M; Buggert M; Chambers BJ; Cuapio Gomez A; Dzidic M; Filipovic I; Flodstrom-Tullberg M; Garcia M; Gorin J-B; Gredmark-Russ S; Hertwig L; Klingstrom J; Kokkinou E; Kvedaraite E; Lourda M; Mjosberg J; Maucourant C; Norrby-Teglund A; Palma Medina LM; Parrot T; Perez-Potti A; Ponzetta A; Ringqvist E; Rivera-Ballesteros O; Rooyackers O; Sandberg JK; Sandberg JT; Sekine T; Svensson M; Varnaite R; Wullimann D; Eriksson LI; Aleman S; Malmberg K-J; Stralin K; Bjorkstrom NK
Article: BMC MEDICINE. 2022;20(1):173
Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections
Jahagirdar S; Morris L; Benis N; Oppegaard O; Svenson M; Hyldegaard O; Skrede S; Norrby-Teglund A; dos Santos VAPM; Saccenti E
Article: JOURNAL OF IMMUNOLOGY. 2022;208(5):1170-1179
Mucosa-Associated Invariant T Cell Hypersensitivity to Staphylococcus aureus Leukocidin ED and Its Modulation by Activation
Boulouis C; Leeansyah E; Shambat SM; Norrby-Teglund A; Sandberg JK
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2022;52(3):503-510
COVID-19-specific metabolic imprint yields insights into multiorgan system perturbations
Cornillet M; Strunz B; Rooyackers O; Ponzetta A; Chen P; Muvva JR; Akber M; Buggert M; Chambers BJ; Dzidic M; Filipovic I; Gorin J-B; Gredmark-Russ S; Hertwig L; Klingstrom J; Kokkinou E; Kvedaraite E; Lourda M; Mjosberg J; Maucourant C; Norrby-Teglund A; Parrot T; Perez-Potti A; Rivera-Ballesteros O; Sandberg JK; Sandberg JT; Sekine T; Svensson M; Varnaite R; Eriksson LI; Aleman S; Stralin K; Ljunggren H-G; Bjorkstrom NK
Article: FRONTIERS IN MICROBIOLOGY. 2022;13:822243
Consistent Biofilm Formation by Streptococcus pyogenes emm 1 Isolated From Patients With Necrotizing Soft Tissue Infections
Skutlaberg DH; Wiker HG; Mylvaganam H; INFECT Study Grp A; Norrby-Teglund A; Skrede S
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2021;65(11):e0065821-10.1128/aac.00621
Adjunctive Rifampicin Increases Antibiotic Efficacy in Group A Streptococcal Tissue Infection Models
Bergsten H; Medina LMP; Morgan M; Moll K; Skutlaberg DH; Skrede S; Wajima T; Svensson M; Norrby-Teglund A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(40):e2109123118
High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of in COVID-19
Lourda M; Dzidic M; Hertwig L; Bergsten H; Medina LMP; Sinha I; Kvedaraite E; Chen P; Muvva JR; Gorin J-B; Cornillet M; Emgard J; Moll K; Garcia M; Maleki KT; Klingstrom J; Michaelsson J; Flodstrom-Tullberg M; Brighenti S; Buggert M; Mjosberg J; Malmberg K-J; Sandberg JK; Henter J-I; Folkesson E; Gredmark-Russ S; Sonnerborg A; Eriksson LI; Rooyackers O; Aleman S; Stralin K; Ljunggren H-G; Bjorkstrom NK; Svensson M; Ponzetta A; Norrby-Teglund A; Chambers BJ
Article: JOURNAL OF CLINICAL INVESTIGATION. 2021;131(14):149523
Discriminatory plasma biomarkers predict specific clinical phenotypes of necrotizing soft-tissue infections
Medina LMP; Rath E; Jahagirdar S; Bruun T; Madsen MB; Stralin K; Unge C; Hansen MB; Arnell P; Nekludov M; Hyldegaard O; Lourda M; Santos VAPMD; Saccenti E; Skrede S; Svensson M; Norrby-Teglund A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(6):e2018587118
Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity
Kvedaraite E; Hertwig L; Sinha I; Ponzetta A; Myrberg IH; Lourda M; Dzidic M; Akber M; Klingstrom J; Folkesson E; Muvva JR; Chen P; Gredmark-Russ S; Brighenti S; Norrby-Teglund A; Eriksson LI; Rooyackers O; Aleman S; Stralin K; Ljunggren H-G; Ginhoux F; Bjorkstrom NK; Henter J-I; Svensson M
Article: CLINICAL INFECTIOUS DISEASES. 2021;72(2):293-300
Risk Factors and Predictors of Mortality in Streptococcal Necrotizing Soft-tissue Infections: A Multicenter Prospective Study
Bruun T; Rath E; Madsen MB; Oppegaard O; Nekludov M; Arnell P; Karlsson Y; Babbar A; Bergey F; Itzek A; Hyldegaard O; Norrby-Teglund A; Skrede S
Article: SCIENCE IMMUNOLOGY. 2020;5(51):eabe1670
MAIT cell activation and dynamics associated with COVID-19 disease severity
Parrot T; Gorin J-B; Ponzetta A; Maleki KT; Kammann T; Emgard J; Perez-Potti A; Sekine T; Rivera-Ballesteros O; Gredmark-Russ S; Rooyackers O; Folkesson E; Eriksson LI; Norrby-Teglund A; Ljunggren H-G; Bjorkstrom NK; Aleman S; Buggert M; Klingstrom J; Stralin K; Sandberg JK
Article: JOURNAL OF PROTEOME RESEARCH. 2020;19(2):688-698
Integrated Univariate, Multivariate, and Correlation-Based Network Analyses Reveal Metabolite-Specific Effects on Bacterial Growth and Biofilm Formation in Necrotizing Soft Tissue Infections
Afzal M; Saccenti E; Madsen MB; Hansen MB; Hyldegaard O; Skrede S; dos Santos VAPM; Norrby-Teglund A; Svensson M
Article: JOURNAL OF INNATE IMMUNITY. 2020;12(4):291-303
Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment
Siemens N; Oehmcke-Hecht S; Hossmann J; Skorka SB; Nijhuis RHT; Ruppen C; Skrede S; Rohde M; Schultz D; Lalk M; Itzek A; Pieper DH; van den Bout CJ; Claas ECJ; Kuijper EJ; Mauritz R; Sendi P; Wunderink HF; Norrby-Teglund A
Article: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 2020;1294:127-150
Pathogenic Mechanisms of Streptococcal Necrotizing Soft Tissue Infections
Siemens N; Snall J; Svensson M; Norrby-Teglund A
Article: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 2020;1294:105-125
Treatment of Necrotizing Soft Tissue Infections: IVIG
Madsen MB; Bergsten H; Norrby-Teglund A
Article: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 2020;1294:1-6
The INFECT-Project: An International and Multidisciplinary Project on Necrotizing Soft Tissue Infections
Svensson M; Norrby-Teglund A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(51):25923-25931
MAIT Cells Are Major Contributors to the Cytokine Response in Group A Streptococcal Toxic Shock Syndrome
Emgard J; Bergsten H; McCormick JK; Barrantes I; Skrede S; Sandberg JK; Norrby-Teglund A
Article: INTENSIVE CARE MEDICINE. 2019;45(9):1241-1251
Patient's characteristics and outcomes in necrotising soft-tissue infections: results from a Scandinavian, multicentre, prospective cohort study
Madsen MB; Skrede S; Perner A; Arnell P; Nekludov M; Bruun T; Karlsson Y; Hansen MB; Polzik P; Hedetoft M; Rosen A; Saccenti E; Bergey F; dos Santos VAPM; Norrby-Teglund A; Hyldegaard O; Bidstrup D; Baernthsen NF; Frendo GH; Jansen EC; Madsen LB; Mueller RB; Pedersen EMJ; Petersen MW; Ravn F; Smidt-Nielsen IFG; Wahl AM; Wulffeld S; Aronsson S; Rosemar A; Trogen J; Nedrebo T; Oppegaard O; Rath E; Saevik M
Article: NATURE COMMUNICATIONS. 2019;10(1):3846
Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections
Thaenert R; Itzek A; Hossmann J; Hamisch D; Madsen MB; Hyldegaard O; Skrede S; Bruun T; Norrby-Teglund A; Medina E; Pieper DH; Oppegaard O; Rath E; Nedrebo T; Arnell P; Rosen A; Polzik P; Hansen MB; Svensson M; Snall J; Karlsson Y; Nekludov M
Article: JOURNAL OF INFECTIOUS DISEASES. 2019;220(4):710-719
Necrotizing Soft Tissue Infection Staphylococcus aureus but not S. pyogenes Isolates Display High Rates of Internalization and Cytotoxicity Toward Human Myoblasts
Baude J; Bastien S; Gillet Y; Leblanc P; Itzek A; Tristan A; Bes M; Duguez S; Moreau K; Diep BA; Norrby-Teglund A; Henry T; Vandenesch F; Arnell P; Bergey F; Dos Santos VAPM; Hyldegaard O; Nekludov M; Pieper D; Skrede S; Svensson M
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2019;139(6):1284-1293
Group A Streptococcal DNase Sda1 Impairs Plasmacytoid Dendritic Cells' Type 1 Interferon Response
Keller N; Woytschak J; Heeb LEM; Maggio EM; Shambat SM; Snall J; Hyldegaard O; Boyman O; Norrby-Teglund A; Zinkernagel AS
Article: CLINICAL MICROBIOLOGY AND INFECTION (CMI). 2019;25(4):512.e7-512.e13
Human polyspecific immunoglobulin attenuates group A streptococcal virulence factor activity and reduces disease severity in a murine necrotizing fasciitis model
Tarnutzer A; Andreoni F; Keller N; Zuercher C; Norrby-Teglund A; Schuepbach RA; Zinkernagel AS
Article: SCIENTIFIC REPORTS. 2018;8(1):13428
High HMGB1 levels in sputum are related to pneumococcal bacteraemia but not to disease severity in community-acquired pneumonia
Alpkvist H; Athlin S; Molling P; Norrby-Teglund A; Stralin K
Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2018;62(8):1171-1177
Diabetes and necrotizing soft tissue infectionsA prospective observational cohort study: Statistical analysis plan
Rosen A; Arnell P; Madsen MB; Nedrebo BG; Norrby-Teglund A; Hyldegaard O; dos Santos VM; Bergey F; Saccenti E; Skrede S
Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2018;62(2):272-279
Necrotizing soft tissue infections - a multicentre, prospective observational study (INFECT): protocol and statistical analysis plan
Madsen MB; Skrede S; Bruun T; Arnell P; Rosen A; Nekludov M; Karlsson Y; Bergey F; Saccenti E; dos Santos VAPM; Perner A; Norrby-Teglund A; Hyldegaard O
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:236
Protein SIC Secreted from Streptococcus pyogenes Forms Complexes with Extracellular Histones That Boost Cytokine Production
Westman J; Chakrakodi B; Snall J; Morgelin M; Madsen MB; Hyldegaard O; Neumann A; Frick I-M; Norrby-Teglund A; Bjorck L; Herwald H
Article: JOURNAL OF INNATE IMMUNITY. 2018;10(1):30-43
Immunoregulation of Neutrophil Extracellular Trap Formation by Endothelial-Derived p33 (gC1q Receptor)
Neumann A; Papareddy P; Westman J; Hyldegaard O; Snall J; Norrby-Teglund A; Herwald H
Article: INTENSIVE CARE MEDICINE. 2017;43(11):1585-1593
Immunoglobulin G for patients with necrotising soft tissue infection (INSTINCT): a randomised, blinded, placebo-controlled trial
Madsen MB; Hjortrup PB; Hansen MB; Lange T; Norrby-Teglund A; Hyldegaard O; Perner A
Article: BMC MEDICINE. 2017;15(1):172
Macrophage activation-like syndrome: an immunological entity associated with rapid progression to death in sepsis
Kyriazopoulou E; Leventogiannis K; Norrby-Teglund A; Dimopoulos G; Pantazi A; Orfanos SE; Rovina N; Tsangaris I; Gkavogianni T; Botsa E; Chassiou E; Kotanidou A; Kontouli C; Chaloulis P; Velissaris D; Savva A; Cullberg J-S; Akinosoglou K; Gogos C; Armaganidis A; Giamarellos-Bourboulis EJ
Article: PLOS BIOLOGY. 2017;15(7):e2003167
Bacterial deception of MAIT cells in a cloud of superantigen and cytokines
Sandberg JK; Norrby-Teglund A; Leeansyah E
Article: BLOOD. 2017;129(14):1991-2001
Neutrophils acquire the capacity for antigen presentation to memory CD4⁺ T cells in vitro and ex vivo
Vono M; Lin A; Norrby-Teglund A; Koup RA; Liang F; Lore K
Article: CRITICAL CARE MEDICINE. 2017;45(4):591-599
Fever in the Emergency Department Predicts Survival of Patients With Severe Sepsis and Septic Shock Admitted to the ICU
Sunden-Cullberg J; Rylance R; Svefors J; Norrby-Teglund A; Bjork J; Inghammar M
Article: SCIENTIFIC REPORTS. 2017;7:42179
Association between cytokine response, the LRINEC score and outcome in patients with necrotising soft tissue infection: a multicentre, prospective study
Hansen MB; Rasmussen LS; Svensson M; Chakrakodi B; Bruun T; Madsen MB; Perner A; Garred P; Hyldegaard O; Norrby-Teglund A
Article: JOURNAL OF INFECTIOUS DISEASES. 2016;214(12):1876-1883
Phosphoglycerate Kinase-A Novel Streptococcal Factor Involved in Neutrophil Activation and Degranulation
Uhlmann J; Siemens N; Kai-Larsen Y; Fiedler T; Bergman P; Johansson L; Norrby-Teglund A
Article: SCIENTIFIC REPORTS. 2016;6:31360
A point mutation in AgrC determines cytotoxic or colonizing properties associated with phenotypic variants of ST22 MRSA strains
Shambat SM; Siemens N; Monk IR; Mohan DB; Mukundan S; Krishnan KC; Prabhakara S; Snall J; Kearns A; Vandenesch F; Svensson M; Kotb M; Gopal B; Arakere G; Norrby-Teglund A
Article: JCI INSIGHT. 2016;1(10):e87882
Biofilm in group A streptococcal necrotizing soft tissue infections
Siemens N; Chakrakodi B; Shambat SM; Morgan M; Bergsten H; Hyldegaard O; Skrede S; Arnell P; Madsen MB; Johansson L; Juarez J; Bosnjak L; Morgelin M; Svensson M; Norrby-Teglund A
Article: PLOS PATHOGENS. 2016;12(7):e1005732
Genetic Architecture of Group A Streptococcal Necrotizing Soft Tissue Infections in the Mouse
Krishnan KC; Mukundan S; Alagarsamy J; Hur J; Nookala S; Siemens N; Svensson M; Hyldegaard O; Norrby-Teglund A; Kotb M
Article: SCIENTIFIC REPORTS. 2016;6:21288
Differential neutrophil responses to bacterial stimuli: Streptococcal strains are potent inducers of heparin-binding protein and resistin-release
Snall J; Linner A; Uhlmann J; Siemens N; Ibold H; Janos M; Linder A; Kreikemeyer B; Herwald H; Johansson L; Norrby-Teglund A
Article: JOURNAL OF INNATE IMMUNITY. 2016;8(3):243-257
LL-37 Triggers Formation of Streptococcus pyogenes Extracellular Vesicle-Like Structures with Immune Stimulatory Properties
Uhlmann J; Rohde M; Siemens N; Kreikemeyer B; Bergman P; Johansson L; Norrby-Teglund A
Article: PLOS PATHOGENS. 2015;11(12):e1005319
Extracellular Histones Induce Chemokine Production in Whole Blood Ex Vivo and Leukocyte Recruitment In Vivo
Westman J; Papareddy P; Dahlgren MW; Chakrakodi B; Norrby-Teglund A; Smeds E; Linder A; Morgelin M; Johansson-Lindbom B; Egesten A; Herwald H
Article: SCIENTIFIC REPORTS. 2015;5:16945
Increased cytotoxicity and streptolysin O activity in group G streptococcal strains causing invasive tissue infections
Siemens N; Kittang BR; Chakrakodi B; Oppegaard O; Johansson L; Bruun T; Mylvaganam H; Svensson M; Skrede S; Norrby-Teglund A
Article: MICROBIOLOGYOPEN. 2015;4(5):774-789
Sequence variability is correlated with weak immunogenicity in Streptococcus pyogenes M protein
Lannergard J; Kristensen BM; Gustafsson MCU; Persson JJ; Norrby-Teglund A; Stalhammar-Carlemalm M; Lindahl G
Article: DISEASE MODELS & MECHANISMS. 2015;8(11):1413-1425
Modelling staphylococcal pneumonia in a human 3D lung tissue model system delineates toxin-mediated pathology
Shambat SM; Chen P; Anh TNH; Bergsten H; Vandenesch F; Siemens N; Lina G; Monk IR; Foster TJ; Arakere G; Svensson M; Norrby-Teglund A
Article: CLINICAL INFECTIOUS DISEASES. 2014;59(6):851-857
Clinical Efficacy of Polyspecific Intravenous Immunoglobulin Therapy in Patients With Streptococcal Toxic Shock Syndrome: A Comparative Observational Study
Linner A; Darenberg J; Sjolin J; Henriques-Normark B; Norrby-Teglund A
Article: PLOS ONE. 2014;9(8):e106107
Levels of Alpha-Toxin Correlate with Distinct Phenotypic Response Profiles of Blood Mononuclear Cells and with agr Background of Community-Associated Staphylococcus aureus Isolates
Shambat SM; Haggar A; Vandenesch F; Lina G; van Wamel WJB; Arakere G; Svensson M; Norrby-Teglund A
Article: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2014;4:4
HMGB1 in severe soft tissue infections caused by Streptococcus pyogenes
Johansson L; Snall J; Sendi P; Linner A; Thulin P; Linder A; Treutiger C-J; Norrby-Teglund A
Article: FRONTIERS IN PUBLIC HEALTH. 2013;1:51
Short- and long-term mortality in severe sepsis/septic shock in a setting with low antibiotic resistance: a prospective observational study in a Swedish university hospital.
Linnér A; Sundén-Cullberg J; Johansson L; Hjelmqvist H; Norrby-Teglund A; Treutiger CJ
Article: JOURNAL OF INNATE IMMUNITY. 2013;5(6):581-590
Prognostic Value and Therapeutic Potential of TREM-1 in Streptococcus pyogenes-Induced Sepsis
Horst SA; Linner A; Beineke A; Lehne S; Hoeltje C; Hecht A; Norrby-Teglund A; Medina E; Goldmann O
Article: PLOS ONE. 2013;8(3):e60013
Genome Sequencing Unveils a Novel Sea Enterotoxin-Carrying PVL Phage in Staphylococcus aureus ST772 from India
Prabhakara S; Khedkar S; Shambat SM; Srinivasan R; Basu A; Norrby-Teglund A; Seshasayee ASN; Arakere G
Article: CRITICAL CARE. 2012;16(4):R149
Risk assessment in sepsis: a new prognostication rule by APACHE II score and serum soluble urokinase plasminogen activator receptor
Giamarellos-Bourboulis EJ; Norrby-Teglund A; Mylona V; Savva A; Tsangaris I; Dimopoulou I; Mouktaroudi M; Raftogiannis M; Georgitsi M; Linner A; Adamis G; Antonopoulou A; Apostolidou E; Chrisofos M; Katsenos C; Koutelidakis I; Kotzampassi K; Koratzanis G; Koupetori M; Kritselis I; Lymberopoulou K; Mandragos K; Marioli A; Sunden-Cullberg J; Mega A; Prekates A; Routsi C; Gogos C; Treutiger C-J; Armaganidis A; Dimopoulos G
Article: JOURNAL OF CLINICAL MICROBIOLOGY. 2012;50(5):1626-1631
Clinical and Microbiologic Characteristics of Invasive Streptococcus pyogenes Infections in North and South India
Haggar A; Nerlich A; Kumar R; Abraham VJ; Brahmadathan KN; Ray P; Dhanda V; Joshua JMJ; Mehra N; Bergmann R; Chhatwal GS; Norrby-Teglund A
Article: PLOS ONE. 2012;7(4):e35218
Intracellular Streptococcus pyogenes in Human Macrophages Display an Altered Gene Expression Profile
Hertzen E; Johansson L; Kansal R; Hecht A; Dahesh S; Janos M; Nizet V; Kotb M; Norrby-Teglund A
Article: BLOOD. 2011;118(9):2589-2598
Coagulation, an ancestral serine protease cascade, exerts a novel function in early immune defense
Loof TG; Morgelin M; Johansson L; Oehmcke S; Olin AI; Dickneite G; Norrby-Teglund A; Theopold U; Herwald H
Article: CELL HOST AND MICROBE. 2011;10(2):147-157
The Hypervariable Region of Streptococcus pyogenes M Protein Escapes Antibody Attack by Antigenic Variation and Weak Immunogenicity
Lannergard J; Gustafsson MCU; Waldemarsson J; Norrby-Teglund A; Stalhammar-Carlemalm M; Lindahl G
Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2010;21(8):1151-1156
Reduced iNOS expression in adenoids from children with otitis media with effusion
Granath A; Norrby-Teglund A; Uddman R; Cardell L-O
Article: JOURNAL OF IMMUNOLOGY. 2010;185(4):2372-2381
Inducible Cyclooxygenase Released Prostaglandin E₂ Modulates the Severity of Infection Caused by Streptococcus pyogenes
Goldmann O; Hertzen E; Hecht A; Schmidt H; Lehne S; Norrby-Teglund A; Medina E
Article: CLINICAL MICROBIOLOGY AND INFECTION (CMI). 2010;16(8):1155-1158
Extracellular adherence protein (Eap) from Staphylococcus aureus does not function as a superantigen
Haggar A; Flock J-I; Norrby-Teglund A
Article: CLINICAL INFECTIOUS DISEASES. 2010;51(1):58-65
Getting under the Skin: The Immunopathogenesis of Streptococcus pyogenes Deep Tissue Infections
Johansson L; Thulin P; Low DE; Norrby-Teglund A
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2010;130(5):1365-1372
Erysipelas Caused by Group A Streptococcus Activates the Contact System and Induces the Release of Heparin-Binding Protein
Linder A; Johansson L; Thulin P; Hertzen E; Morgelin M; Christensson B; Bjorck L; Norrby-Teglund A; Akesson P
Article: JOURNAL OF INNATE IMMUNITY. 2010;2(6):534-545
M1 Protein-Dependent Intracellular Trafficking Promotes Persistence and Replication of Streptococcus pyogenes in Macrophages
Hertzen E; Johansson L; Wallin R; Schmidt H; Kroll M; Rehn AP; Kotb M; Morgelin M; Norrby-Teglund A
Article: PLOS PATHOGENS. 2009;5(12):e1000698
Protein C Inhibitor-A Novel Antimicrobial Agent
Malmstrom E; Morgelin M; Malmsten M; Johansson L; Norrby-Teglund A; Shannon O; Schmidtchen A; Meijers JCM; Herwald H
Article: JOURNAL OF IMMUNOLOGY. 2009;183(6):4047-4054
Neutrophil-Derived Hyperresistinemia in Severe Acute Streptococcal Infections
Johansson L; Linner A; Sunden-Cullberg J; Haggar A; Herwald H; Lore K; Treutiger C-J; Norrby-Teglund A
Article: EMERGING INFECTIOUS DISEASES. 2009;15(2):223-232
Bacterial Phenotype Variants in Group B Streptococcal Toxic Shock Syndrome
Sendi P; Johansson L; Dahesh S; Van Sorge NM; Darenberg J; Norgren M; Sjolin J; Nizet V; Norrby-Teglund A
Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 2009;41(11-12):823-830
Severe group A streptococcal infections in Uppsala County, Sweden: Clinical and molecular characterization of a case cluster from 2006 to 2007
Vikerfors A; Haggar A; Darenberg J; Low A; Melhu A; Hedlund J; Sylvan S; Norrby-Teglund A; Eriksson B-M
Article: PLOS PATHOGENS. 2008;4(9):e1000149
Antibodies against a surface protein of Streptococcus pyogenes promote a pathological inflammatory response
Kahn F; Morgelin M; Shannon O; Norrby-Teglund A; Herwald H; Olin AI; Bjorck L
Article: INFECTION AND IMMUNITY. 2008;76(9):3951-3958
CD46 contributes to the severity of group A streptococcal infection
Lovkvist L; Sjolinder H; Wehelie R; Aro H; Norrby-Teglund A; Plant L; Jonsson A-B
Article: INFECTION AND IMMUNITY. 2008;76(8):3399-3404
Cathelicidin LL-37 in severe Streptococcus pyogenes soft tissue infections in humans
Johansson L; Thulin P; Sendi P; Hertzen E; Linder A; Akesson P; Low DE; Agerberth B; Norrby-Teglund A
Article: BLOOD. 2008;111(6):3070-3080
Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation
von Koeckritz-Blickwede M; Goldmann O; Thulin P; Heinemann K; Norrby-Teglund A; Rohde M; Medina E
Article: CELLULAR MICROBIOLOGY. 2008;10(2):404-414
Soluble M1 protein of Streptococcus pyogenes triggers potent T cell activation
Pahlman LI; Olin AI; Darenberg J; Morgelin M; Kotb M; Herwald H; Norrby-Teglund A
Article: MOLECULAR MICROBIOLOGY. 2007;65(5):1147-1157
Severe streptococcal infection is associated with M protein-induced platelet activation and thrombus formation
Shannon O; Hertzen E; Norrby-Teglund A; Morgelin M; Sjobring U; Bjorck L
Article: CLINICAL INFECTIOUS DISEASES. 2007;45(4):450-458
Molecular and clinical characteristics of invasive group A streptococcal infection in Sweden
Darenberg J; Luca-Harari B; Jasir A; Sandgren A; Pettersson H; Schalen C; Norgren M; Romanus V; Norrby-Teglund A; Normark BH
Article: CRITICAL CARE MEDICINE. 2007;35(6):1536-1542
Pronounced elevation of resistin correlates with severity of disease in severe sepsis and septic shock
Sunden-Cullberg J; Nystrom T; Lee ML; Mullins GE; Tokics L; Andersson J; Norrby-Teglund A; Treutiger CJ
Article: BLOOD. 2006;108(6):2055-2063
Kinin receptor expression during Staphylococcus aureus infection
Bengtson SH; Phagoo SB; Norrby-Teglund A; Pahlman L; Morgelin M; Zuraw BL; Leeb-Lundberg LMF; Herwald H
Article: JOURNAL OF IMMUNOLOGY. 2006;177(2):1221-1228
Streptococcal M protein:: A multipotent and powerful inducer of inflammation
Pahlman LI; Moergelin M; Eckert J; Johansson L; Russell W; Riesbeck K; Soehnlein O; Lindbom L; Norrby-Teglund A; Schumann RR; Bjoerck L; Herwald H
Article: PLOS MEDICINE. 2006;3(3):371-379
Viable group A streptococci in macrophages during acute soft tissue infection
Thulin P; Johansson L; Low DE; Gan BS; Kotb M; McGeer A; Norrby-Teglund A
Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 2006;38(11-12):983-987
Release of SpeA from Streptococcus pyogenes after exposure to penicillin:: Dependency on dose and inhibition by clindamycin
Goscinski G; Tano E; Thulin P; Norrby-Teglund A; Sjolin J
Article: JOURNAL OF INFECTIOUS DISEASES. 2005;192(2):210-217
Dual effects of extracellular adherence protein from Staphylococcus aureus on peripheral blood mononuclear cells
Haggar A; Shannon O; Norrby-Teglund A; Flock JI
Article: JOURNAL OF CLINICAL MICROBIOLOGY. 2005;43(7):3101-3109
Variations in emm type among group A streptococcal isolates causing invasive or noninvasive infections in a nationwide study
Ekelund K; Darenberg J; Norrby-Teglund A; Hoffmann S; Bang D; Skinhoj P; Konradsen HB
Article: CRITICAL CARE MEDICINE. 2005;33(3):564-573
Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock
Sundén-Cullberg J; Norrby-Teglund A; Rouhiainen A; Rauvala H; Herman G; Tracey KJ; Lee ML; Andersson J; Tokics L; Treutiger CJ
Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 2005;37(3):166-172
Successful management of severe group A streptococcal soft tissue infections using an aggressive medical regimen including intravenous polyspecific immunoglobulin together with a conservative surgical approach
Norrby-Teglund A; Muller MP; Mcgeer A; Gan BS; Guru V; Bohnen J; Thulin P; Low DE
Article: CLINICAL INFECTIOUS DISEASES. 2004;38(6):836-842
Differences in potency of intravenous polyspecific immunoglobulin G against streptococcal and staphylococcal superantigens:: Implications for therapy of toxic shock syndrome
Darenberg J; Söderquist B; Normark BH; Norrby-Teglund A
Article: CLINICAL AND VACCINE IMMUNOLOGY. 2004;11(2):250-254
Rectal nitric oxide gas and stool cytokine levels during the course of infectious gastroenteritis
Enocksson A; Lundberg J; Weitzberg E; Norrby-Teglund A; Svenungsson B
Article: CELL. 2004;116(3):367-379
M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage
Herwald H; Cramer H; Mörgelin M; Russell W; Sollenberg U; Norrby-Teglund A; Flodgaard H; Lindbom L; Björck L
Article: BONE MARROW TRANSPLANTATION. 2004;33(1):79-85
Viridans streptococcal septicaemia in neutropenic patients:: role of proinflammatory cytokines
Ihendyane N; Sparrelid E; Wretlind B; Remberger M; Andersson J; Ljungman P; Ringdén O; Normark BH; Allen U; Low DE; Norrby-Teglund A
Article: CLINICAL INFECTIOUS DISEASES. 2003;37(3):333-340
Intravenous immunoglobulin G therapy in streptococcal toxic shock syndrome:: A European randomized, double-blind, placebo-controlled trial
Darenberg J; Ihendyane N; Sjölin J; Aufwerber E; Haidl S; Follin P; Andersson J; Norrby-Teglund A
Article: INFECTION AND IMMUNITY. 2003;71(5):2310-2317
Extracellular adherence protein from Staphylococcus aureus enhances internalization into eukaryotic cells
Haggar A; Hussain M; Lönnies H; Herrmann M; Norrby-Teglund A; Flock JI
Article: CURRENT INFECTIOUS DISEASE REPORTS. 2003;5(1):28-37
The Treatment of Severe Group A Streptococcal Infections.
Norrby-Teglund A; Norrby SR; Low DE
Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 2003;35(9):683-689
Intravenous immunoglobulin adjunctive therapy in sepsis, with special emphasis on severe invasive group A streptococcal infections
Norrby-Teglund A; Ihendyane N; Darenberg J
Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 2003;35(9):665-669
Association of human leukocyte antigen with outcomes of infectious diseases: The streptococcal experience
Kotb M; Norrby-Teglund A; McGeer A; Green K; Low DE
Article: NATURE MEDICINE. 2002;8(12):1398-1404
An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections
Kotb M; Norrby-Teglund A; McGeer A; El-Sherbini H; Dorak MT; Khurshid A; Green K; Peeples J; Wade J; Thomson G; Schwartz B; Low DE
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2002;32(9):2570-2577
Differential presentation of group A streptococcal superantigens by HLA class II DQ and DR alleles
Norrby-Teglund A; Nepom GT; Kotb M
Article: INFECTION AND IMMUNITY. 2001;69(8):4988-4995
Reciprocal, temporal expression of SpeA and SpeB by invasive M1T1 group a streptococcal isolates in vivo
Kazmi SU; Kansal R; Aziz RK; Hooshdaran M; Norrby-Teglund A; Low DE; Halim AB; Kotb M
Article: CLINICAL INFECTIOUS DISEASES. 2000;31(5):1175-1182
Relative neutralizing activity in polyspecific IgM, IgA, and IgG preparations against group A streptococcal superantigens
Norrby-Teglund A; Ihendyane N; Kansal R; Basma H; Kotb M; Andersson J; Hammarström L
Article: INFECTION AND IMMUNITY. 2000;68(11):6362-6369
Inverse relation between disease severity and expression of the streptococcal cysteine protease, SpeB, among clonal M1T1 isolates recovered from invasive group A streptococcal infection cases.
Kansal RG; McGeer A; Low DE; Norrby-Teglund A; Kotb M
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2000;30(11):3247-3255
Host variation in cytokine responses to superantigens determine the severity of invasive group A streptococcal infection
Norrby-Teglund A; Chatellier S; Low DE; McGeer A; Green K; Kotb M
Article: PANCREAS. 2000;21(1):41-51
Trypsin stimulates production of cytokines from peritoneal macrophages in vitro and in vivo.
Lundberg AH; Eubanks JW; Henry J; Sabek O; Kotb M; Gaber L; Norby-Teglund A; Gaber AO
Article: INFECTION AND IMMUNITY. 2000;68(6):3523-3534
Genetic relatedness and superantigen expression in group A streptococcus serotype MZ isolates from patients with severe and nonsevere invasive diseases
Chatellier S; Ihendyane N; Kansal RG; Khambaty F; Basma H; Norrby-Teglund A; Low DE; McGeer A; Kotb M
Article: INFECTION AND IMMUNITY. 1999;67(4):1871-1877
Risk factors in the pathogenesis of invasive group A streptococcal infections: role of protective humoral immunity.
Basma H; Norrby-Teglund A; Guedez Y; McGeer A; Low DE; El-Ahmedy O; Schwartz B; Kotb M
Article: INFECTION AND IMMUNITY. 1998;66(5):2279-2283
Opsonic antibodies to the surface M protein of group A streptococci in pooled normal immunoglobulins (IVIG): potential impact on the clinical efficacy of IVIG therapy for severe invasive group A streptococcal infections.
Basma H; Norrby-Teglund A; McGeer A; Low DE; El-Ahmedy O; Dale JB; Schwartz B; Kotb M
Article: CLINICAL INFECTIOUS DISEASES. 1998;26(3):631-638
Varying titers of neutralizing antibodies to streptococcal superantigens in different preparations of normal polyspecific immunoglobulin G: implications for therapeutic efficacy.
Norrby-Teglund A; Basma H; Andersson J; McGeer A; Low DE; Kotb M
Article: INFECTION AND IMMUNITY. 1997;65(12):5209-5215
Differential induction of Th1 versus Th2 cytokines by group A streptococcal toxic shock syndrome isolates.
Norrby-Teglund A; Lustig R; Kotb M
Article: INFECTION AND IMMUNITY. 1996;64(12):5395-5398
Evidence for the presence of streptococcal-superantigen-neutralizing antibodies in normal polyspecific immunoglobulin G
NorrbyTeglund A; Kaul R; Low DE; McGeer A; Andersson J; Andersson U; Kotb M
Article: JOURNAL OF IMMUNOLOGY. 1996;156(8):3057-3064
Plasma from patients with severe invasive group A streptococcal infections treated with normal polyspecific IgG inhibits streptococcal superantigen-induced T cell proliferation and cytokine production
NorrbyTeglund A; Kaul R; Low DE; McGeer A; Newton DW; Andersson J; Andersson U; Kotb M
Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 1995;27(2):125-130
Correlation between serum TNF alpha and IL6 levels and severity of group A streptococcal infections.
Norrby-Teglund A; Pauksens K; Norgren M; Holm SE
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Review: TIDSSKRIFT FOR DEN NORSKE LEGEFORENING. 2024;144(3)
Necrotizing soft tissue infections
Gundersen IM; Bruun T; Almeland SK; Skutlaberg DH; Nedrebo T; Rath E; Oppegaard O; Guttormsen AB; Norrby-Teglund A; Mosevoll KA; Skrede S
Editorial comment: CLINICAL INFECTIOUS DISEASES. 2020;71(7):1772-1775
Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections
Bergsten H; Madsen MB; Bergey F; Hyldegaard O; Skrede S; Arnell P; Oppegaard O; Itzek A; Perner A; Svensson M; Norrby-Teglund A
Editorial comment: CLINICAL INFECTIOUS DISEASES. 2020;70(7):1461-1462
Is It Time to Reconsider the Group A Streptococcal Rheumatogenic Concept?
Norrby-Teglund A; Siemens N
Editorial comment: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 2020;1294:V-VI
Necrotizing Soft Tissue Infections Clinical and Pathogenic Aspects Preface
Norrby-Teglund A; Svensson M; Skrede S
Review: CLINICAL MICROBIOLOGY AND INFECTION (CMI). 2020;26(1):8-17
Necrotizing skin and soft-tissue infections in the intensive care unit
Peetermans M; de Prost N; Eckmann C; Norrby-Teglund A; Skrede S; De Waele JJ
Review: CLINICAL INFECTIOUS DISEASES. 2018;67(9):1434-1436
Polyspecific Intravenous Immunoglobulin in Clindamycin-treated Patients With Streptococcal Toxic Shock Syndrome: A Systematic Review and Meta-analysis
Parks T; Wilson C; Curtis N; Norrby-Teglund A; Sriskandan S
Editorial comment: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(38):10000-10002
Shocking superantigens promote establishment of bacterial infection
Siemens N; Norrby-Teglund A
Other: ENVIRONMENTAL MICROBIOLOGY REPORTS. 2016;8(5):555
In tribute to Singh Chhatwal
Norrby-Teglund A
Letter: CLINICAL INFECTIOUS DISEASES. 2015;60(2):324-325
Efficacy of Polyspecific Intravenous Immunoglobulin Therapy in Streptococcal Toxic Shock Syndrome Reply
Linner A; Sjolin J; Darenberg J; Henriques-Normark B; Norrby-Teglund A
Published conference paper: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. 2013;42:S13-S16
Beyond the traditional immune response: bacterial interaction with phagocytic cells
Norrby-Teglund A; Johansson L
Review: CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY. 2013;368:173-188
Immunopathogenesis of Streptococcal Deep Tissue Infections
Johansson L; Norrby-Teglund A
Review: INFECTION. 2008;36(2):100-111
Invasive group B streptococcal disease in non-pregnant adults - A review with emphasis on skin and soft-tissue infections
Sendi P; Johansson L; Norrby-Teglund A
Letter: CLINICAL INFECTIOUS DISEASES. 2007;44(8):1141-1142
Streptococcus agalactiae in relapsing cellulitis
Sendi P; Graber P; Johansson L; Norrby-Teglund A; Zimmerli W
Review: JOURNAL OF INTERNAL MEDICINE. 2006;260(6):509-516
Intravenous polyclonal IgM-enriched immunoglobulin therapy in sepsis:: a review of clinical efficacy in relation to microbiological aetiology and severity of sepsis
Norrby-Teglund A; Haque KN; Hammarstrom L
Review: CURRENT OPINION IN INFECTIOUS DISEASES. 2006;19(3):231-236
The role of high mobility group box-1 protein in severe sepsis
Sunden-Cullberg J; Norrby-Teglund A; Treutiger CJ
Editorial comment: NATURE MEDICINE. 2004;10(8):780-781
Staphylococcal protein A inflames the lungs
Normark BH; Normark S; Norrby-Teglund A
Published conference paper: JOURNAL OF INFECTIOUS DISEASES. 2001;184(7):853-860
Evidence for superantigen involvement in severe group A streptococcal tissue infections
Norrby-Teglund A; Thulin P; Gan BS; Kotb M; McGeer A; Andersson J; Low DE
Editorial comment: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 2001;33(8):634-637
Culture-negative severe septic shock: Indications for Streptococcal aetiology based on plasma antibodies and superantigenic activity
Norrby-Teglund A; Berdal JE
Editorial comment: JOURNAL OF MEDICAL MICROBIOLOGY. 2000;49(10):849-852
Host-microbe interactions in the pathogenesis of invasive group A streptococcal infections
Norrby-Teglund A; Kotb M
Published conference paper: CLINICAL INFECTIOUS DISEASES. 1999;28(4):800-807
Intravenous immunoglobulin therapy for streptococcal toxic shock syndrome--a comparative observational study. The Canadian Streptococcal Study Group.
Kaul R; McGeer A; Norrby-Teglund A; Kotb M; Schwartz B; O'Rourke K; Talbot J; Low DE
Review: CURRENT OPINION IN INFECTIOUS DISEASES. 1998;11(3):285-291
Novel therapies in streptococcal toxic shock syndrome: attenuation of virulence factor expression and modulation of the host response
Norrby-Teglund A; Stevens DL
Review: ANNALS OF THE ACADEMY OF MEDICINE SINGAPORE. 1997;26(5):691-693
Infections due to group A streptococcus: new concepts and potential treatment strategies.
Norrby SR; Norrby-Teglund A
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