Publications CIM

Selected publications 2020

A hexavalent Coxsackievirus B vaccine is highly immunogenic and has a strong protective capacity in mice and nonhuman primates.
Stone VM, Hankaniemi MM, Laitinen OH, Sioofy-Khojine AB, Lin A, Diaz Lozano IM, et al
Sci Adv 2020 May;6(19):eaaz2433

Polarization of Human Monocyte-Derived Cells With Vitamin D Promotes Control of Mycobacterium tuberculosis Infection.
Rao Muvva J, Parasa VR, Lerm M, Svensson M, Brighenti S
Front Immunol 2019 ;10():3157

Human endometrial MAIT cells are transiently tissue resident and respond to Neisseria gonorrhoeae.
Bister J, Crona Guterstam Y, Strunz B, Dumitrescu B, Haij Bhattarai K, Özenci V, et al
Mucosal Immunol 2020 Aug;():

Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli.
Boulouis C, Sia WR, Gulam MY, Teo JQM, Png YT, Phan TK, et al
PLoS Biol. 2020 06;18(6):e3000644

Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection.
Lal KG, Kim D, Costanzo MC, Creegan M, Leeansyah E, Dias J, et al
Nat Commun 2020 01;11(1):272

Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19
Sekine T, Perez-Potti A, Rivera-Ballesteros O, Strålin K, Gorin JB, Olsson A, Llewellyn-Lacey S,Kamal H, Bogdanovic G, Muschiol S, Wullimann DJ, Kamman T, Emgård J, Parrot T, Folkesson E, Karolinska COVID-19 Study Group, Rooyackers O, Eriksson LI, Henter JI, Sönnerborg A, Allander T, Albert. J, Nielsen M, Klingström J, Gredmark-Rus S, Björkström NK, Sandberg JK, Price DA, Ljunggren HG, Aleman S, Buggert M. Published in Cell.

TOX is expressed by exhausted and polyfunctional human effector memory CD8+ T cells.
Sekine T, Perez-Potti A, Nguyen S, Gorin JB, Wu VH, Gostick E, et al
Sci Immunol 2020 Jul;5(49):

Selected publications 2019

MAIT Cells Are Major Contributors to the Cytokine Response in Group A Streptococcal Toxic Shock Syndrome.
Emgård J, Bergsten H, McCormick JK, Barrantes I, Skrede S, Sandberg JK, et al
Proc. Natl. Acad. Sci. U.S.A. 2019 12;116(51):25923-25931

The viral protein corona directs viral pathogenesis and amyloid aggregation.
Ezzat K, Pernemalm M, Pålsson S, Roberts TC, Järver P, Dondalska A, et al
Nat Commun 2019 05;10(1):2331

Remodeling of secretory lysosomes during education tunes functional potential in NK cells.
Goodridge JP, Jacobs B, Saetersmoen ML, Clement D, Hammer Q, Clancy T, et al
Nat Commun 2019 01;10(1):514

Keller N,J Woytschak, L Heeb, E Marques Maggio, Marques Maggio E, Mairpady Shambat S, Snäll J, O Hyldegaard, O Boyman, A Norrby-Teglund, A S.
Zinkernagel. Group A streptococcal DNase Sda1 impairs plasmacytoid dendritic cell’s type I IFN response. J Invest Dermatol, 2019 Jun;139(6):1284-1293

Human polyspecific immunoglobulin attenuates group A streptococcal virulence factor activity and reduces disease severity in a murine necrotizing fasciitis model.
Tarnutzer A, Andreoni F, Keller N, Zürcher C, Norrby-Teglund A, Schüpbach RA, et al
Clin. Microbiol. Infect. 2019 Apr;25(4):512.e7-512.e13

Imbalance of Genes Encoding Natural Killer Immunoglobulin-like Receptors and Human Leukocyte Antigen in Patients With Biliary Cancer
Cornillet M, Jansson H, Schaffer M, Hertwig L, Berglin L, Zimmer CL, Johansson H, Ellis E, Isaksson B, Gonzalez-Galarza FF, Middleton D, Malmberg KJ, Sparrelid E, Björkström NK.
Published in Gastroenterology
In the media: KI News

Chronic hepatitis delta virus infection leads to functional impairment and severe loss of MAIT cells
Dias J, Hengst J, Parrot T, Leeansyah E, Lunemann S, Malone DFG, Hardtke S, Strauss O, Zimmer CL, Berglin L, Schirdewahn T, Ciesek S, Marquardt N, von Hahn T, Manns MP, Cornberg M, Ljunggren HG, Wedemeyer H, Sandberg JK, Björkström NK.
Published in Journal of Hepatology
In the media: KI News

Liver macrophages regulate systemic metabolism through non-inflammatory factors
Morgantini C, Jager J, Li X, Levi L, Azzimato V, Sulen A, Barreby E, Xu E, Tencerova M, Näslund E, Kumar C, Verdeguer F, Straniero S, Hultenby K, Björkström NK, Ellis E, Rydén M, Kutter C, Hurrell T, Lauschke VM, Boucher J, Tomčala A, Krejčová G, Bajgar A, Aouadi M.
Published in Nature Metabolism

Selected publications 2018

Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML.
Björklund AT, Carlsten M, Sohlberg E, Liu LL, Clancy T, Karimi M, et al
Clin. Cancer Res. 2018 Apr;24(8):1834-1844

Polyspecific Intravenous Immunoglobulin in Clindamycin-treated Patients With Streptococcal Toxic Shock Syndrome: A Systematic Review and Meta-analysis.
Parks T, Wilson C, Curtis N, Norrby-Teglund A, Sriskandan S
Clin. Infect. Dis. 2018 Oct;67(9):1434-1436

Protein SIC Secreted from Streptococcus pyogenes Forms Complexes with Extracellular Histones That Boost Cytokine Production.
Westman J, Chakrakodi B, Snäll J, Mörgelin M, Bruun Madsen M, Hyldegaard O, et al
Front Immunol 2018 ;9():236

Severely Impaired Control of Bacterial Infections in a Patient With Cystic Fibrosis Defective in Mucosal-Associated Invariant T Cells.
Pincikova T, Paquin-Proulx D, Moll M, Flodström-Tullberg M, Hjelte L, Sandberg JK
Chest 2018 May;153(5):e93-e96

Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease.
Buggert M, Nguyen S, McLane LM, Steblyanko M, Anikeeva N, Paquin-Proulx D, et al
PLoS Pathog. 2018 04;14(4):e1006973

Influenza-Activated ILC1s Contribute to Antiviral Immunity Partially Influenced by Differential GITR Expression.
Vashist N, Trittel S, Ebensen T, Chambers BJ, Guzmán CA, Riese P
Front Immunol 2018 ;9():505

A Coxsackievirus B vaccine protects against virus-induced diabetes in an experimental mouse model of type 1 diabetes.
Stone VM, Hankaniemi MM, Svedin E, Sioofy-Khojine A, Oikarinen S, Hyöty H, et al
Diabetologia 2018 02;61(2):476-481

Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation.
Emgård J, Kammoun H, García-Cassani B, Chesné J, Parigi SM, Jacob JM, et al
Immunity 2018 01;48(1):120-132.e8

Primary sclerosing cholangitis leads to dysfunction and loss of MAIT cells
von Seth E, Zimmer CL, Reuterwall-Hansson M, Barakat A, Arnelo U, Bergquist A, Ivarsson MA, Björkström NK.
Published in European Journal of Immunology

Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity
Strunz B, Hengst J, Deterding K, Manns MP, Cornberg M, Ljunggren HG, Wedemeyer H, Björkström NK
Published in Nature Communications
In the media: KI News, SR P1 Vetenskapsradion, Health Europa

Increased NK Cell Function After Cessation of Long-Term Nucleos(t)ide Analogue Treatment in Chronic Hepatitis B Is Associated With Liver Damage and HBsAg Loss
Zimmer CL, Rinker F, Höner Zu Siederdissen C, Manns MP, Wedemeyer H, Cornberg M, Björkström NK
Published in Journal of Infectious Diseases
In the media: KI News

Hepatitis B virus-specific T cell responses after stopping nucleos(t)ide analogue therapy in HBeAg negative chronic hepatitis B
Rinker F, Zimmer CL, Siederdissen CHZ, Manns MP, Kraft ARM, Wedemeyer H, Björkström NK, Cornberg M
Published in Journal of Hepatology
In the media: KI News

IL13Rα2 expression identifies tissue-resident IL-22-producing PLZF+ innate T cells in the human liver
Paquin-Proulx D, Greenspun BC, Pasquet L, Strunz B, Aleman S, Falconer K, Terabe M, Berzofsky JA, Sandberg JK, Melum E, Nixon DF, Björkström NK
Published in European Journal of Immunology

Selected publications 2017

A Link Between a Common Mutation in CFTR and Impaired Innate and Adaptive Viral Defense.
Svedin E, Utorova R, Hühn MH, Larsson PG, Stone VM, Garimella M, et al
J. Infect. Dis. 2017 12;216(10):1308-1317

Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69-CD56dim cells.
Marquardt N, Kekäläinen E, Chen P, Kvedaraite E, Wilson JN, Ivarsson MA, et al
J. Allergy Clin. Immunol. 2017 Apr;139(4):1321-1330.e4

Human hantavirus infection elicits pronounced redistribution of mononuclear phagocytes in peripheral blood and airways.
Scholz S, Baharom F, Rankin G, Maleki KT, Gupta S, Vangeti S, et al
PLoS Pathog. 2017 Jun;13(6):e1006462

Downmodulation of Effector Functions in NK Cells upon Toxoplasma gondii Infection.
Sultana M, Du A, Carow B, Angbjär C, Weidner J, Kanatani S, et al
Infect. Immun. 2017 10;85(10):

PPAR-γ promotes type 2 immune responses in allergy and nematode infection.
Chen T, Tibbitt C, Feng X, Stark J, Rohrbeck L, Rausch L, et al
Sci Immunol 2017 Mar;2(9):

Expression of CD226 is associated to but not required for NK cell education.
Wagner A, Kadri N, Snäll J, Brodin P, Gilfillan S, Colonna M, et al
Nat Commun 2017 05;8():15627

Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines.
Dias J, Leeansyah E, Sandberg J
Proc. Natl. Acad. Sci. U.S.A. 2017 07;114(27):E5434-E5443

Bacterial deception of MAIT cells in a cloud of superantigen and cytokines.
Sandberg J, Norrby-Teglund A, Leeansyah E
PLoS Biol. 2017 Jul;15(7):e2003167

Perturbed CD8 T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals.
Tauriainen J, Scharf L, Frederiksen J, Naji A, Ljunggren H, Sönnerborg A, et al
Sci Rep 2017 01;7():40354

Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69CD56 cells.
Marquardt N, Kekäläinen E, Chen P, Kvedaraite E, Wilson J, Ivarsson M, et al
J. Allergy Clin. Immunol. 2017 Apr;139(4):1321-1330.e4

Gingival Tissue Inflammation Promotes Increased Matrix Metalloproteinase-12 Production by CD200Rlow Monocyte-Derived Cells in Periodontitis.
Björnfot Holmström S, Clark R, Zwicker S, Bureik D, Kvedaraite E, Bernasconi E, et al
J. Immunol. 2017 12;199(12):4023-4035

Voltage-dependent calcium channel signaling mediates GABAA receptor-induced migratory activation of dendritic cells infected by Toxoplasma gondii.
Kanatani S, Fuks JM, Olafsson EB, Westermark L, Chambers B, Varas-Godoy M, et al
PLoS Pathog. 2017 Dec;13(12):e1006739

Selected publications 2016

Nonreversible MAIT cell-dysfunction in chronic hepatitis C virus infection despite successful interferon-free therapy.
Hengst J, Strunz B, Deterding K, Ljunggren H, Leeansyah E, Manns M, et al
Eur. J. Immunol. 2016 09;46(9):2204-10

Genetic Architecture of Group A Streptococcal Necrotizing Soft Tissue Infections in the Mouse.
Chella Krishnan K, Mukundan S, Alagarsamy J, Hur J, Nookala S, Siemens N, et al
PLoS Pathog. 2016 07;12(7):e1005732

Phosphoglycerate Kinase-A Novel Streptococcal Factor Involved in Neutrophil Activation and Degranulation.
Uhlmann J, Siemens N, Kai-Larsen Y, Fiedler T, Bergman P, Johansson L, et al
J. Infect. Dis. 2016 Dec;214(12):1876-1883

Enteroviral proteases: structure, host interactions and pathogenicity.
Laitinen O, Svedin E, Kapell S, Nurminen A, Hytönen V, Flodström-Tullberg M
Rev. Med. Virol. 2016 07;26(4):251-67

An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets.
Domsgen E, Lind K, Kong L, Hühn M, Rasool O, van Kuppeveld F, et al
Sci Rep 2016 12;6():39378

Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion.
Paquin-Proulx D, Gibbs A, Bächle S, Checa A, Introini A, Leeansyah E, et al
J. Immunol. 2016 09;197(5):1843-51

Biofilm in group A streptococcal necrotizing soft tissue infections.
Siemens N, Chakrakodi B, Shambat SM, Morgan M, Bergsten H, Hyldegaard O, et al
JCI Insight 2016 07;1(10):e87882

The heterogeneity of human CD127(+) innate lymphoid cells revealed by single-cell RNA sequencing.
Björklund ÅK, Forkel M, Picelli S, Konya V, Theorell J, Friberg D, et al
Nat. Immunol. 2016 Apr;17(4):451-60

MAIT cells reside in the female genital mucosa and are biased towards IL-17 and IL-22 production in response to bacterial stimulation.
Gibbs A, Leeansyah E, Introini A, Paquin-Proulx D, Hasselrot K, Andersson E, et al
Mucosal Immunol 2017 01;10(1):35-45

Emerging insights into natural killer cells in human peripheral tissues.
Björkström NK, Ljunggren HG, Michaëlsson J
Nat. Rev. Immunol. 2016 04;16(5):310-20

Specificity and dynamics of effector and memory CD8 T cell responses in human tick-borne encephalitis virus infection.
Blom K, Braun M, Pakalniene J, Dailidyte L, Béziat V, Lampen MH, et al
PLoS Pathog. 2015 Jan;11(1):e1004622

Selected publications 2015

Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function.
Schlums H, Cichocki F, Tesi B, Theorell J, Beziat V, Holmes TD, et al
Immunity 2015 Mar;42(3):443-56

Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection.
Leeansyah E, Svärd J, Dias J, Buggert M, Nyström J, Quigley MF, et al
PLoS Pathog. 2015 Aug;11(8):e1005072

HIV Type 1 Disease Progression to AIDS and Death in a Rural Ugandan Cohort Is Primarily Dependent on Viral Load Despite Variable Subtype and T-Cell Immune Activation Levels.
Eller MA, Opollo MS, Liu M, Redd AD, Eller LA, Kityo C, et al
J. Infect. Dis. 2015 May;211(10):1574-84

A preclinical study on the efficacy and safety of a new vaccine against Coxsackievirus B1 reveals no risk for accelerated diabetes development in mouse models.
Larsson PG, Lakshmikanth T, Laitinen OH, Utorova R, Jacobson S, Oikarinen M, et al
Diabetologia 2015 Feb;58(2):346-54

Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells.
Marquardt N, Béziat V, Nyström S, Hengst J, Ivarsson MA, Kekäläinen E, et al
J. Immunol. 2015 Mar;194(6):2467-71

Effects of HDV infection and pegylated interferon α treatment on the natural killer cell compartment in chronically infected individuals.
Lunemann S, Malone DF, Grabowski J, Port K, Béziat V, Bremer B, et al
Gut 2015 Mar;64(3):469-82

Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes.
Willinger T, Staron M, Ferguson SM, De Camilli P, Flavell RA
Proc. Natl. Acad. Sci. U.S.A. 2015 Apr;112(14):4423-8

CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells.
Edlund A, Esguerra JL, Wendt A, Flodström-Tullberg M, Eliasson L
BMC Med 2014 May;12():87

Selected publications 2014

Detection of IL-17A-producing peripheral blood monocytes in Langerhans cell histiocytosis patients.
Lourda M, Olsson-Åkefeldt S, Gavhed D, Björnfot S, Clausen N, Hjalmars U, et al
Clin. Immunol. 2014 Jul;153(1):112-22

Technical advance: live-imaging analysis of human dendritic cell migrating behavior under the influence of immune-stimulating reagents in an organotypic model of lung.
Nguyen Hoang AT, Chen P, Björnfot S, Högstrand K, Lock JG, Grandien A, et al
J. Leukoc. Biol. 2014 Sep;96(3):481-9

Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development.
Leeansyah E, Loh L, Nixon DF, Sandberg JK
Nat Commun 2014 ;5():3143

Gap junction intercellular communications regulate NK cell activation and modulate NK cytotoxic capacity.
Tittarelli A, Mendoza-Naranjo A, Farías M, Guerrero I, Ihara F, Wennerberg E, et al
J. Immunol. 2014 Feb;192(3):1313-9

HMGB1 in severe soft tissue infections caused by Streptococcus pyogenes.
Johansson L, Snäll J, Sendi P, Linnér A, Thulin P, Linder A, et al
Front Cell Infect Microbiol 2014 ;4():4

Levels of alpha-toxin correlate with distinct phenotypic response profiles of blood mononuclear cells and with agr background of community-associated Staphylococcus aureus isolates.
Mairpady Shambat S, Haggar A, Vandenesch F, Lina G, van Wamel WJ, Arakere G, et al
PLoS ONE 2014 ;9(8):e106107

Clinical efficacy of polyspecific intravenous immunoglobulin therapy in patients with streptococcal toxic shock syndrome: a comparative observational study.
Linnér A, Darenberg J, Sjölin J, Henriques-Normark B, Norrby-Teglund A
Clin. Infect. Dis. 2014 Sep;59(6):851-7

Tightly regulated migratory subversion of immune cells promotes the dissemination of Toxoplasma gondii.
Weidner JM, Barragan A
Int. J. Parasitol. 2014 Feb;44(2):85-90

Previous maternal infection protects offspring from enterovirus infection and prevents experimental diabetes development in mice.
Larsson PG, Lakshmikanth T, Svedin E, King C, Flodström-Tullberg M
Diabetologia 2013 Apr;56(4):867-74

Selected publications 2013

Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection.
Leeansyah E, Ganesh A, Quigley MF, Sönnerborg A, Andersson J, Hunt PW, et al
Blood 2013 Feb;121(7):1124-35

Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis.
Carow B, Reuschl AK, Gavier-Widén D, Jenkins BJ, Ernst M, Yoshimura A, et al
PLoS Pathog. 2013 ;9(7):e1003442

Differentiation and functional regulation of human fetal NK cells.
Ivarsson MA, Loh L, Marquardt N, Kekäläinen E, Berglin L, Björkström NK, et al
J. Clin. Invest. 2013 Sep;123(9):3889-901

NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs.
Béziat V, Liu LL, Malmberg JA, Ivarsson MA, Sohlberg E, Björklund AT, et al
Blood 2013 Apr;121(14):2678-88

Hantavirus-infection confers resistance to cytotoxic lymphocyte-mediated apoptosis.
Gupta S, Braun M, Tischler ND, Stoltz M, Sundström KB, Björkström NK, et al
PLoS Pathog. 2013 Mar;9(3):e1003272

Rapid cytoskeleton remodelling in dendritic cells following invasion by Toxoplasma gondii coincides with the onset of a hypermigratory phenotype.
Weidner JM, Kanatani S, Hernández-Castañeda MA, Fuks JM, Rethi B, Wallin RP, et al
Cell. Microbiol. 2013 Oct;15(10):1735-52

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