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Publications

Selected publications 2018

Severely Impaired Control of Bacterial Infections in a Patient With Cystic Fibrosis Defective in Mucosal-Associated Invariant T Cells.
Pincikova T, Paquin-Proulx D, Moll M, Flodström-Tullberg M, Hjelte L, Sandberg JK
Chest 2018 May;153(5):e93-e96

Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease.
Buggert M, Nguyen S, McLane LM, Steblyanko M, Anikeeva N, Paquin-Proulx D, et al
PLoS Pathog. 2018 04;14(4):e1006973

Influenza-Activated ILC1s Contribute to Antiviral Immunity Partially Influenced by Differential GITR Expression.
Vashist N, Trittel S, Ebensen T, Chambers BJ, Guzmán CA, Riese P
Front Immunol 2018 ;9():505

Voltage-dependent calcium channel signaling mediates GABAA receptor-induced migratory activation of dendritic cells infected by Toxoplasma gondii.
Kanatani S, Fuks JM, Olafsson EB, Westermark L, Chambers B, Varas-Godoy M, et al
PLoS Pathog. 2017 Dec;13(12):e1006739

A Coxsackievirus B vaccine protects against virus-induced diabetes in an experimental mouse model of type 1 diabetes.
Stone VM, Hankaniemi MM, Svedin E, Sioofy-Khojine A, Oikarinen S, Hyöty H, et al
Diabetologia 2018 02;61(2):476-481

Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation.
Emgård J, Kammoun H, García-Cassani B, Chesné J, Parigi SM, Jacob JM, et al
Immunity 2018 01;48(1):120-132.e8

Gingival Tissue Inflammation Promotes Increased Matrix Metalloproteinase-12 Production by CD200Rlow Monocyte-Derived Cells in Periodontitis.
Björnfot Holmström S, Clark R, Zwicker S, Bureik D, Kvedaraite E, Bernasconi E, et al
J. Immunol. 2017 12;199(12):4023-4035

 

Selected publications 2017

A Link Between a Common Mutation in CFTR and Impaired Innate and Adaptive Viral Defense.
Svedin E, Utorova R, Hühn MH, Larsson PG, Stone VM, Garimella M, et al
J. Infect. Dis. 2017 12;216(10):1308-1317

Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69-CD56dim cells.
Marquardt N, Kekäläinen E, Chen P, Kvedaraite E, Wilson JN, Ivarsson MA, et al
J. Allergy Clin. Immunol. 2017 Apr;139(4):1321-1330.e4

Human hantavirus infection elicits pronounced redistribution of mononuclear phagocytes in peripheral blood and airways.
Scholz S, Baharom F, Rankin G, Maleki KT, Gupta S, Vangeti S, et al
PLoS Pathog. 2017 Jun;13(6):e1006462

Downmodulation of Effector Functions in NK Cells upon Toxoplasma gondii Infection.
Sultana M, Du A, Carow B, Angbjär C, Weidner J, Kanatani S, et al
Infect. Immun. 2017 10;85(10):

PPAR-γ promotes type 2 immune responses in allergy and nematode infection.
Chen T, Tibbitt C, Feng X, Stark J, Rohrbeck L, Rausch L, et al
Sci Immunol 2017 Mar;2(9):

Expression of CD226 is associated to but not required for NK cell education.
Wagner A, Kadri N, Snäll J, Brodin P, Gilfillan S, Colonna M, et al
Nat Commun 2017 05;8():15627

Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines.
Dias J, Leeansyah E, Sandberg J
Proc. Natl. Acad. Sci. U.S.A. 2017 07;114(27):E5434-E5443

Bacterial deception of MAIT cells in a cloud of superantigen and cytokines.
Sandberg J, Norrby-Teglund A, Leeansyah E
PLoS Biol. 2017 Jul;15(7):e2003167

Perturbed CD8 T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals.
Tauriainen J, Scharf L, Frederiksen J, Naji A, Ljunggren H, Sönnerborg A, et al
Sci Rep 2017 01;7():40354

Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69CD56 cells.
Marquardt N, Kekäläinen E, Chen P, Kvedaraite E, Wilson J, Ivarsson M, et al
J. Allergy Clin. Immunol. 2017 Apr;139(4):1321-1330.e4

 

Selected publications 2016

Human hantavirus infection elicits pronounced redistribution of mononuclear phagocytes in peripheral blood and airways.
Scholz S, Baharom F, Rankin G, Maleki KT, Gupta S, Vangeti S, et al
PLoS Pathog. 2017 Jun;13(6):e1006462

Nonreversible MAIT cell-dysfunction in chronic hepatitis C virus infection despite successful interferon-free therapy.
Hengst J, Strunz B, Deterding K, Ljunggren H, Leeansyah E, Manns M, et al
Eur. J. Immunol. 2016 09;46(9):2204-10

Genetic Architecture of Group A Streptococcal Necrotizing Soft Tissue Infections in the Mouse.
Chella Krishnan K, Mukundan S, Alagarsamy J, Hur J, Nookala S, Siemens N, et al
PLoS Pathog. 2016 07;12(7):e1005732

Phosphoglycerate Kinase-A Novel Streptococcal Factor Involved in Neutrophil Activation and Degranulation.
Uhlmann J, Siemens N, Kai-Larsen Y, Fiedler T, Bergman P, Johansson L, et al
J. Infect. Dis. 2016 Dec;214(12):1876-1883

Enteroviral proteases: structure, host interactions and pathogenicity.
Laitinen O, Svedin E, Kapell S, Nurminen A, Hytönen V, Flodström-Tullberg M
Rev. Med. Virol. 2016 07;26(4):251-67

An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets.
Domsgen E, Lind K, Kong L, Hühn M, Rasool O, van Kuppeveld F, et al
Sci Rep 2016 12;6():39378

Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion.
Paquin-Proulx D, Gibbs A, Bächle S, Checa A, Introini A, Leeansyah E, et al
J. Immunol. 2016 09;197(5):1843-51

Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69CD56 cells.
Marquardt N, Kekäläinen E, Chen P, Kvedaraite E, Wilson J, Ivarsson M, et al
J. Allergy Clin. Immunol. 2017 Apr;139(4):1321-1330.e4

Human hantavirus infection elicits pronounced redistribution of mononuclear phagocytes in peripheral blood and airways.
Scholz S, Baharom F, Rankin G, Maleki KT, Gupta S, Vangeti S, et al
PLoS Pathog. 2017 Jun;13(6):e1006462

Biofilm in group A streptococcal necrotizing soft tissue infections.
Siemens N, Chakrakodi B, Shambat SM, Morgan M, Bergsten H, Hyldegaard O, et al
JCI Insight 2016 07;1(10):e87882

The heterogeneity of human CD127(+) innate lymphoid cells revealed by single-cell RNA sequencing.
Björklund ÅK, Forkel M, Picelli S, Konya V, Theorell J, Friberg D, et al
Nat. Immunol. 2016 Apr;17(4):451-60

MAIT cells reside in the female genital mucosa and are biased towards IL-17 and IL-22 production in response to bacterial stimulation.
Gibbs A, Leeansyah E, Introini A, Paquin-Proulx D, Hasselrot K, Andersson E, et al
Mucosal Immunol 2017 01;10(1):35-45

Emerging insights into natural killer cells in human peripheral tissues.
Björkström NK, Ljunggren HG, Michaëlsson J
Nat. Rev. Immunol. 2016 04;16(5):310-20

Specificity and dynamics of effector and memory CD8 T cell responses in human tick-borne encephalitis virus infection.
Blom K, Braun M, Pakalniene J, Dailidyte L, Béziat V, Lampen MH, et al
PLoS Pathog. 2015 Jan;11(1):e1004622

 

Selected publications 2015

Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function.
Schlums H, Cichocki F, Tesi B, Theorell J, Beziat V, Holmes TD, et al
Immunity 2015 Mar;42(3):443-56

Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection.
Leeansyah E, Svärd J, Dias J, Buggert M, Nyström J, Quigley MF, et al
PLoS Pathog. 2015 Aug;11(8):e1005072

HIV Type 1 Disease Progression to AIDS and Death in a Rural Ugandan Cohort Is Primarily Dependent on Viral Load Despite Variable Subtype and T-Cell Immune Activation Levels.
Eller MA, Opollo MS, Liu M, Redd AD, Eller LA, Kityo C, et al
J. Infect. Dis. 2015 May;211(10):1574-84

A preclinical study on the efficacy and safety of a new vaccine against Coxsackievirus B1 reveals no risk for accelerated diabetes development in mouse models.
Larsson PG, Lakshmikanth T, Laitinen OH, Utorova R, Jacobson S, Oikarinen M, et al
Diabetologia 2015 Feb;58(2):346-54

Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells.
Marquardt N, Béziat V, Nyström S, Hengst J, Ivarsson MA, Kekäläinen E, et al
J. Immunol. 2015 Mar;194(6):2467-71

Effects of HDV infection and pegylated interferon α treatment on the natural killer cell compartment in chronically infected individuals.
Lunemann S, Malone DF, Grabowski J, Port K, Béziat V, Bremer B, et al
Gut 2015 Mar;64(3):469-82

Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes.
Willinger T, Staron M, Ferguson SM, De Camilli P, Flavell RA
Proc. Natl. Acad. Sci. U.S.A. 2015 Apr;112(14):4423-8

CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells.
Edlund A, Esguerra JL, Wendt A, Flodström-Tullberg M, Eliasson L
BMC Med 2014 May;12():87

 

Selected publications 2014

Detection of IL-17A-producing peripheral blood monocytes in Langerhans cell histiocytosis patients.
Lourda M, Olsson-Åkefeldt S, Gavhed D, Björnfot S, Clausen N, Hjalmars U, et al
Clin. Immunol. 2014 Jul;153(1):112-22

Technical advance: live-imaging analysis of human dendritic cell migrating behavior under the influence of immune-stimulating reagents in an organotypic model of lung.
Nguyen Hoang AT, Chen P, Björnfot S, Högstrand K, Lock JG, Grandien A, et al
J. Leukoc. Biol. 2014 Sep;96(3):481-9

Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development.
Leeansyah E, Loh L, Nixon DF, Sandberg JK
Nat Commun 2014 ;5():3143

Gap junction intercellular communications regulate NK cell activation and modulate NK cytotoxic capacity.
Tittarelli A, Mendoza-Naranjo A, Farías M, Guerrero I, Ihara F, Wennerberg E, et al
J. Immunol. 2014 Feb;192(3):1313-9

Effects of HDV infection and pegylated interferon α treatment on the natural killer cell compartment in chronically infected individuals.
Lunemann S, Malone DF, Grabowski J, Port K, Béziat V, Bremer B, et al
Gut 2015 Mar;64(3):469-82

Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes.
Willinger T, Staron M, Ferguson SM, De Camilli P, Flavell RA
Proc. Natl. Acad. Sci. U.S.A. 2015 Apr;112(14):4423-8

HMGB1 in severe soft tissue infections caused by Streptococcus pyogenes.
Johansson L, Snäll J, Sendi P, Linnér A, Thulin P, Linder A, et al
Front Cell Infect Microbiol 2014 ;4():4

Levels of alpha-toxin correlate with distinct phenotypic response profiles of blood mononuclear cells and with agr background of community-associated Staphylococcus aureus isolates.
Mairpady Shambat S, Haggar A, Vandenesch F, Lina G, van Wamel WJ, Arakere G, et al
PLoS ONE 2014 ;9(8):e106107

Clinical efficacy of polyspecific intravenous immunoglobulin therapy in patients with streptococcal toxic shock syndrome: a comparative observational study.
Linnér A, Darenberg J, Sjölin J, Henriques-Normark B, Norrby-Teglund A
Clin. Infect. Dis. 2014 Sep;59(6):851-7

Tightly regulated migratory subversion of immune cells promotes the dissemination of Toxoplasma gondii.
Weidner JM, Barragan A
Int. J. Parasitol. 2014 Feb;44(2):85-90

Previous maternal infection protects offspring from enterovirus infection and prevents experimental diabetes development in mice.
Larsson PG, Lakshmikanth T, Svedin E, King C, Flodström-Tullberg M
Diabetologia 2013 Apr;56(4):867-74

 

Selected publications 2013

Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection.
Leeansyah E, Ganesh A, Quigley MF, Sönnerborg A, Andersson J, Hunt PW, et al
Blood 2013 Feb;121(7):1124-35

Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis.
Carow B, Reuschl AK, Gavier-Widén D, Jenkins BJ, Ernst M, Yoshimura A, et al
PLoS Pathog. 2013 ;9(7):e1003442

Differentiation and functional regulation of human fetal NK cells.
Ivarsson MA, Loh L, Marquardt N, Kekäläinen E, Berglin L, Björkström NK, et al
J. Clin. Invest. 2013 Sep;123(9):3889-901

NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs.
Béziat V, Liu LL, Malmberg JA, Ivarsson MA, Sohlberg E, Björklund AT, et al
Blood 2013 Apr;121(14):2678-88

Hantavirus-infection confers resistance to cytotoxic lymphocyte-mediated apoptosis.
Gupta S, Braun M, Tischler ND, Stoltz M, Sundström KB, Björkström NK, et al
PLoS Pathog. 2013 Mar;9(3):e1003272

Rapid cytoskeleton remodelling in dendritic cells following invasion by Toxoplasma gondii coincides with the onset of a hypermigratory phenotype.
Weidner JM, Kanatani S, Hernández-Castañeda MA, Fuks JM, Rethi B, Wallin RP, et al
Cell. Microbiol. 2013 Oct;15(10):1735-52

 

 

Doctoral theses from CIM

2018 

Johanna Snäll: PHAGOCYTIC CELLS AND STREPTOCOCCUS PYOGENES IN INVASIVE INFECTIONS: AN
INFLAMMATORY RELATIONSHIP

 

2017 

Julia Uhlman: Neutrophil interactions with streptococcus pyogenes and staphylococcus aureaus

Emma Svedin: Entervirus infections in type 1 diabetes and cystic fibrosis

Joana Dias: Role of MAIT cells in human antimicrobial immunity

Sofia Björnfot: The role of monocytes in chronic inflammatory diseases

Marianne ForkelI: Innate lymphoid cell heterogeneity in human tissues at steady state and during

 

2016 

David Malone: Innate immunity in the immunopathogenesis of chronic viral infection

Monika Enqvist: Mechanisms influencing natural killer cell recognition of tumour cells

Kim Blom: Cell-mediated immunity to flavivirus infections

Anh Thu Nguyen Hoang: Tissue regulation of dendritic cells : with focus on chemokines, function and migration

Srikanth Mairpady: Host-pathogen interactions in invasive Staphylococcus aureus infections

Lisa Liu: Dynamic shaping of human NK cell receptor repertoires : implications for NK cell-based immunotherapy

Proscovia Naluyima Sekiziyivu: Role of innate cellular immunity in the immunopathogenesis of HIV-1 infection in Uganda

 

2015 

Susanna Bächle: A Virologit's guide to hide and seek: Evasion of innate Immunity by primate lentiviruses

Frank Liang: Innate immune responses in vivo after antigen administration : implications for vaccine development

Samuel Chiang: Functional assays for the diagnosis of primary defects in lymphocyte cytotoxicity

 

2014 

Jonas Fuks: Host molecular determinants of toxoplasma gondii dissemination

Katharina Lind: A battle between host and pathogen: the innate immune response and enterovirus evasion strategies

Anna Linnér: Clinical and pathophysiological aspects of sepsis

Pär Larsson: Interactions Between Enteroviruses and the Host - Implications for Type 1 Diabetes

Martin Ivarsson: The Ontogeny and Regulation of Human Natural Killer Cells

Eva Allerbring: Molecular basis for enhanced T-cell recognition and cross-reactivity

 

2013 

Senait Ashenafi Betemariam: Studies of immune responses in human tuberculosis

Anh Thu Nguyen Hoang: Tissue Regulation of Dendritic Cells: with focus on chemokines, function and migration

Sanna Nyström: Roles of Innate Immune Receptors: Host - Pathogen Interactions and Strengthening Vaccines

Sayma Rahman: Local immune responses in tuberculosis: cytolytic effector functions at the site of mycobacterium tuberculosis Infection

Sofia Andersson: Invariant NKT cells and CD1d in HIV-1 infection

 

2012 

Emily Bond: Studies of human dendritic cells in the skin after antigen exposure

Hannes Uchtenhagen: Elicitation and enhancement of T and B cell responses

Adil Doganay Duru: MHC-class I restricted peptidebasedimmunomodulation of CD8+T and NK cells

Annette Sköld: Strategies for modulation of dendritic cell responses

Sandra Andersson: Formation of the inhibitory KIR repertoire in human natural killer cells

Venkatramanan Mohanram: On HIV-1 restriction in human dendritic cells and peripheral blood mononuclear cells

 

2011 

William C Adams: Regulation of human dendritic cells and T cells by adenovirus vectors types 5 and 35: Implications for vaccine design

Niklas Björkström: Human natural killer cell activation and differentiation in health and viral infection

Michael Alan Eller: Role of cellular immune functions through the course of HIV-1 natural infection in Ugandans

Cornelia Gujer: Regulation of B cell function by plasmacytoid dendritic cells

Oscar Hammarfjord: Toll-like receptor activation induced changes in dendritic cells

Erika Hertzén: Streptococcus pyogenes: life within the macrophage

 

2010  

Mattias Carlsten: Molecular specificities of NK cell-mediated recognition of human tumor cells 

Michael Hühn: Host-microbe interactions in coxsackievirus infection: Focus on innate immunity 

Stella Jacobson: Type 1 diabetes: The autoimmune process and islet transplantation 

Ulrika Johansson: Dendritic cell responses to apoptotic cells : Is there life after death? 

Carlotta Kuylenstierna: Modulation of invariant NKT cell activity by cytokines and receptors in human disease 

 

2009  

Veronica D. Gonzalez: Innate and adaptive cellular immunity in chronic HCV and HIV-1 infection 

Henrik Lambert: Immune evasion and dissemination of Toxoplasma gondii 

Catrine M. Persson: NK cell and dendritic cell interactions in innate immune responses 

 

2008  

Yenan Bryceson: Triggering and mechanisms of natural killer cell mediated cytotoxicity

Monica Hultcrantz: Interferons in antiviral defense and autoimmunity : Focus on type 1 diabetes 

Pontus Thulin: Host-pathogen interactions in severe group A streptococcal infections 

 

2006 

Anna Cederholm: Novel immunological mechanisms and factors in systemic lupus erythematosus-related cardiovascular disease

Jessica Darenberg: Streptococcus pyogenes infections and toxic shock syndrome: Molecular epidemiology and immunotherapy

Máire Quigley: Characterisation of CD8 T cells in mucosa associated lymphoid tissue : Implications for immune control of HIV-1 infection

Annelie Tjernlund: Leukemia inhibitor factor (LIF) and gp130 in early defence against HIV-1 infection

Hong Xu: The role of TPPII in apoptosis control and treatment of malignant disease

 

2005 

Hayrettin Guven: The therapeutic potential of ex vivo expanded natural killer (NK) cells for immunotherapy of cancer

 

2004 

Anna Smed Sörensen: On the role of dendritic cells in HIV-1 infection

 

2003 

Nahla Ihendyane: Pathogenesis and immunotherapy of streptococcal septicemia and shock

 

2002 

Homira Behbahani: Immune dysregulation in HIV-1 infected lymphoid tissue

Scientific report 2009-2012

Here you can download the latest Scientific report 2009-2012 from CIM