Publications Center for Infectious Medicine (CIM)

In addition to the list on this page, publications from 2023 and onwards are listed on each research group page.

2022

CD116+ fetal precursors migrate to the perinatal lung and give rise to human alveolar macrophages.
Evren E, Ringqvist E, Doisne JM, Thaller A, Sleiers N, Flavell RA, Di Santo JP, Willinger T
J Exp Med 2022 02;219(2): PMID: 35019940 

Broad anti-SARS-CoV-2 antibody immunity induced by heterologous ChAdOx1/mRNA-1273 vaccination.
Kaku CI, Champney ER, Normark J, Garcia M, Johnson CE, Ahlm C, Christ W, Sakharkar M, Ackerman ME, Klingström J, Forsell MNE, Walker LM. Science 2022 03;375(6584):1041-1047 PMID: 35143256; PMCID: PMC8939765.

Perturbed NK-cell homeostasis associated with disease severity in chronic neutropenia.
Sohlberg E, Pfefferle A, Heggernes Ask E, Tschan-Plessl A, Jacobs B, Netskar H, Lorenz S, Kanaya M, Kosugi-Kanaya M, Meinke S, Mörtberg A, Höglund P, Sundin M, Carlsson G, Palmblad J, Malmberg KJ
Blood 2022 02;139(5):704-716. PMID: 34699594 DOI: 10.1182/blood.2021013233

A single-cell map of vascular and tissue lymphocytes identifies proliferative TCF-1+ human innate lymphoid cells.
Gao Y, Alisjahbana A, Boey DZH, Mohammad I, Sleiers N, Dahlin JS, Willinger T
Front Immunol 2022 ;13():902881 PMID: 35967297

Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant.
Gao Y, Cai C, Grifoni A, Müller TR, Niessl J, Olofsson A, Humbert M, Hansson L, Österborg A, Bergman P, Chen P, Olsson A, Sandberg JK, Weiskopf D, Price DA, Ljunggren HG, Karlsson AC, Sette A, Aleman S, Buggert M
Nat Med 2022 Mar;28(3):472-476 PMID: 35042228

MAIT cell compartment characteristics are associated with the immune response magnitude to the BNT162b2 mRNA anti-SARS-CoV-2 vaccine.
Boulouis C, Kammann T, Cuapio A, Parrot T, Gao Y, Mouchtaridi E, Wullimann D, Lange J, Chen P, Akber M, Rivera Ballesteros O, Muvva JR, , Smith CIE, Vesterbacka J, Kieri O, Nowak P, Bergman P, Buggert M, Ljunggren HG, Aleman S, Sandberg JK
Mol Med 2022 May;28(1):54 PMID:35562666

Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccination.
Gao Y, Cai C, Wullimann D, Niessl J, Rivera-Ballesteros O, Chen P, Lange J, Cuapio A, Blennow O, Hansson L, Mielke S, Nowak P, Vesterbacka J, Akber M, Perez-Potti A, Sekine T, Müller TR, Boulouis C, Kammann T, Parrot T, Muvva JR, Sobkowiak M, Healy K, Bogdanovic G, Muschiol S, Söderdahl G, Österborg A, Hellgren F, Grifoni A, Weiskopf D, Sette A, Loré K, Sällberg Chen M, Ljungman P, Sandberg JK, Smith CIE, Bergman P, Ljunggren HG, Aleman S, Buggert M
Immunity 2022 Sep;55(9):1732-1746.e5 PMID: 35961317

Adaptive single-KIR+NKG2C+ NK cells expanded from select superdonors show potent missing-self reactivity and efficiently control HLA-mismatched acute myeloid leukemia.
Haroun-Izquierdo A, Vincenti M, Netskar H, van Ooijen H, Zhang B, Bendzick L, Kanaya M, Momayyezi P, Li S, Wiiger MT, Hoel HJ, Krokeide SZ, Kremer V, Tjonnfjord G, Berggren S, Wikström K, Blomberg P, Alici E, Felices M, Önfelt B, Höglund P, Valamehr B, Ljunggren HG, Björklund A, Hammer Q, Kveberg L, Cichocki F, Miller JS, Malmberg KJ, Sohlberg E. J Immunother Cancer. 2022 Nov;10 (11):e005577. doi: 10.1136/jitc-2022-005577. PMID: 36319065 Free PMC article.

SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells.
Hammer Q, Dunst J, Christ W, Picarazzi F, Wendorff M, Momayyezi P, Huhn O, Netskar HK, Maleki KT, García M, Sekine T, Sohlberg E, Azzimato V, Aouadi M; Karolinska COVID-19 Study Group; Severe COVID-19 GWAS Group, Degenhardt F, Franke A, Spallotta F, Mori M, Michaëlsson J, Björkström NK, Rückert T, Romagnani C, Horowitz A, Klingström J, Ljunggren HG, Malmberg KJ.
Cell Rep. 2022 Mar 8;38(10):110503. doi: 10.1016/j.celrep.2022.110503. Epub 2022 Feb 21.
PMID: 35235832 Free PMC article.

2021

MAIT cell activation is associated with disease severity markers in acute hantavirus infection
Maleki KT, Tauriainen J, García M, Kerkman PF, Christ W, Dias J, Wigren Byström J, Leeansyah E, Forsell MN, Ljunggren HG, Ahlm C, Björkström NK, Sandberg JK, Klingström J. Cell Rep Med 2021 Mar;2(3):100220

Divergent clonal differentiation trajectories establish CD8+ memory T cell heterogeneity during acute viral infections in humans.
Mold JE, Modolo L, Hård J, Zamboni M, Larsson AJM, Stenudd M, Eriksson CJ, Durif G, Ståhl PL, Borgström E, Picelli S, Reinius B, Sandberg R, Réu P, Talavera-Lopez C, Andersson B, Blom K, Sandberg JK, Picard F, Michaëlsson J, Frisén J. Cell Rep 2021 May;35(8):109174

Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing.
Mazzurana L, Czarnewski P, Jonsson V, Wigge L, Ringnér M, Williams TC, Ravindran A, Björklund ÅK, Säfholm J, Nilsson G, Dahlén SE, Orre AC, Al-Ameri M, Höög C, Hedin C, Szczegielniak S, Almer S, Mjösberg J. Cell Res 2021 May;31(5):554-568

Expansion of donor-unrestricted MAIT cells with enhanced cytolytic function suitable for TCR redirection.
Parrot T, Healy K, Boulouis C, Sobkowiak MJ, Leeansyah E, Aleman S, Bertoletti A, Sällberg Chen M, Sandberg JK. JCI Insight 2021 03;6(5):

A heterozygous germline CD100 mutation in a family with primary sclerosing cholangitis.
Jiang X, Bergquist A, Löscher BS, Venkatesh G, Mold JE, Holm K, Laerdahl JK, Skånland SS, Maleki KT, Cornillet M, Taskén K, Franke A, Karlsen TH, Björkström NK, Melum E. Sci Transl Med 2021 Feb;13(582):

Distinct developmental pathways from blood monocytes generate human lung macrophage diversity.
Evren E, Ringqvist E, Tripathi KP, Sleiers N, Rives IC, Alisjahbana A, Gao Y, Sarhan D, Halle T, Sorini C, Lepzien R, Marquardt N, Michaëlsson J, Smed-Sörensen A, Botling J, Karlsson MCI, Villablanca EJ, Willinger T. Immunity 2021 Feb;54(2):259-275.e7

Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy.
Strunz B, Bister J, Jönsson H, Filipovic I, Crona-Guterstam Y, Kvedaraite E, Sleiers N, Dumitrescu B, Brännström M, Lentini A, Reinius B, Cornillet M, Willinger T, Gidlöf S, Hamilton RS, Ivarsson MA, Björkström NK. Sci Immunol 2021 Feb;6(56):

Immunomodulatory agents combat multidrug-resistant tuberculosis by improving antimicrobial immunity.
Rao Muvva J, Ahmed S, Rekha RS, Kalsum S, Groenheit R, Schön T, Agerberth B, Bergman P, Brighenti S. J Infect Dis 2021 Feb;():

Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity
Egle Kvedaraite, Laura Hertwig, Indranil Sinha, Andrea Ponzetta, Ida Hed Myrberg, Magda Lourda, Majda Dzidic, Mira Akber, Jonas Klingström, Elin Folkesson, Jagadeeswara Rao Muvva, Puran Chen, Sara Gredmark-Russ, Susanna Brighenti, Anna Norrby-Teglund, Lars I. Eriksson, Olav Rooyackers, Soo Aleman, Kristoffer Strålin, Hans-Gustaf Ljunggren, Florent Ginhoux, Niklas K. Björkström, Jan-Inge Henter, Mattias Svensson, and Karolinska KI/K COVID-19 Study Group. PNAS February 9, 2021 118 (6)

Heterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination.
Normark J, Vikström L, Gwon YD, Persson IL, Edin A, Björsell T, Dernstedt A, Christ W, Tevell S, Evander M, Klingström J, Ahlm C, Forsell M
N Engl J Med 2021 09;385(11):1049-1051 PMID: 34260850; PMCID: PMC8314734.

Coxsackievirus B Vaccines Prevent Infection-Accelerated Diabetes in NOD Mice and Have No Disease-Inducing Effect.
Stone VM, Butrym M, Hankaniemi MM, Sioofy-Khojine AB, Hytönen VP, Hyöty H, Flodström-Tullberg M
Diabetes 2021 12;70(12):2871-2878

Discriminatory plasma biomarkers predict specific clinical phenotypes of necrotizing soft-tissue infections.
Palma Medina LM, Rath E, Jahagirdar S, Bruun T, Madsen MB, Strålin K, Unge C, Hansen MB, Arnell P, Nekludov M, Hyldegaard O, Lourda M, Santos VAMD, Saccenti E, Skrede S, Svensson M, Norrby-Teglund A. J Clin Invest 2021 07;131(14):

High-dimensional immune cell profiling reveals phenotypic heterogeneity and disease-specific alterations of polymorphonuclear leukocytes in COVID-19.
M Lourda*, M Dzidic*, L Hertwig^*, H Bergsten, L M Palma Medina, E Kvedaraite, P Chen, R Muvva Jagadeeswara, J-B Gorin, M Cornillet, J Emgård, K Moll, M Garcia, K Maleki, J Klingström, J Michaelsson, M Flodström-Tullberg, S Brighenti, M Buggert, J Mjösberg, K-J Malmberg, J Sandberg, J-I Henter, E Folkesson, S Gredmark Russ, L I Eriksson, O Rooyackers, S Aleman, K Strålin, H-G Ljunggren, N K Björkström, M Svensson, A Ponzetta^#, A Norrby-Teglund^#, BJ Chambers^#; and the Karolinska COVID-19 Study Group. Proc Natl Acad Sci USA 2021; 118(40):e2109123118. # shared senior

Preferential and persistent impact of acute HIV-1 infection on CD4+ iNKT cells in colonic mucosa.
Paquin-Proulx D, Lal KG, Phuang-Ngern Y, Creegan M, Tokarev A, Suhkumvittaya S, Alrubayyi A, Kroon E, Pinyakorn S, Slike BM, Bolton DL, Krebs SJ, Eller LA, Sajjaweerawan C, Pagliuzza A, Chomont N, Rerknimitr R, Chomchey N, Phanuphak N, de Souza MS, Michael NL, Robb ML, Ananworanich J, Sandberg JK, Eller MA, Schuetz A,. Proc Natl Acad Sci U S A 2021 Nov;118(46): PMID: 34753817