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Research Division of Genome Biology

The research conducted at the Research Division of Genome Biology explores various aspects of genome metabolism, and how their perturbation can lead to disease. Besides our basic research activities, and with the help of the national platforms available at Karolinska campus, we also investigate in translational aspects that can derive in new treatments for various diseases.

Research interests

At present, the Division integrates the activities of five groups.

Research in the Bartek group focuses on various mechanistic aspects of the DNA damage response. Of particular interest is discovery of targets and markers for personalized cancer treatment and finding novel components or mechanisms of genome integrity maintenance. In a second line of research the Bartek group aims to better understand the principles of ribosome biogenesis surveillance, that is, how cells are sensing defects in ribosome production.

The Fernández-Capetillo laboratory focuses on the use of cell-based phenotypic screens for the development of new therapies or molecules of biomedical interest. In contrast to target-oriented approaches, phenotypic screens focus on identifying compounds that can yield a specific phenotype (e.g. killing cancer cells, or limiting the toxicity of deleterious mutations), leaving the target identification for a later step. Despite much of the efforts from the pharmaceutical industry in the recent decades have opted for target-oriented projects, truth is that a large part of the medicines that are used today were discovered through phenotypic approaches, and in some cases the true target remains unknown. Our research mostly focuses on diseases that are largely neglected by the industry, or in the discovery of new uses for already existing medicines for the treatment of other conditions.

Research Community Program: PhenoTarget

Circle icon with circles within, with the text PhenoTarget.
Photo: PhenoTarget.

PhenoTarget, a Research Community Progam to ultimately improve the state-of-the-art drug development workflow and increase the number of drugs successfully approved.

Research groups

Jiri Bartek group
Research on DNA damage response, DNA repair and mechanisms of genome integrity maintenance.

Oscar Fernández-Capetillo group
Exploiting cell-based phenotypic screens for the development of new medicines.

Simon Elsässer group
Chemical and synthetic systems biology; chromatin, epigenetics, and small proteome discovery.

Magda Bienko Group
Our research focuses on understanding the interplay between genome organization and gene expression.

Nicola Crosetto Group
We develop new microscopy and sequencing methods to study genome fragility and tumor heterogeneity.

Students Photo: Erik Cronberg

Education

Our division is organizing a doctoral course on Cancer Drug Discovery, with a focus on Drug Discovery, in September 2020.

Contact

Per Moberg

Head of Division

Address

Research Division of Genome Biology
Science for Life Laboratory
Tomtebodavägen 23A
171 65 Solna

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