Unit of Molecular Toxicology

Our research is aimed at identifying and characterizing molecular and biochemical processes that are induced by exposure to toxicants including engineered nanomaterials and other advanced materials.

Part of the:

Institute of Environmental Medicine

Publications
Funding
Staff and contact
Other activities

Publications

Selected publications

Article: ACS NANO. 2025;19(20):19057-19079
Nanodiamonds Interact with Primary Human Macrophages and Dendritic Cells Evoking a Vigorous Interferon Response
Malina T; Kaur J; Martin S; Gallud A; Katayama S; Gazzi A; Orecchioni M; Petr M; Srejber M; Haag L; Hamawandi B; Toprak MS; Kere J; Delogu LG; Fadeel B
Article: NANO TODAY. 2024;54:102084
Immune profiling and tracking of two-dimensional transition metal dichalcogenides in cells and tissues
Gazzi A; Fusco L; Orecchioni M; Keshavan S; Shin Y; Grivel J-C; Rinchai D; Ahmed EI; Elhanani O; Furesi G; Rauner M; Keren L; Ley K; Casiraghi C; Bedognetti D; Fadeel B; Delogu LG
Article: MATTER. 2024;7(1):191-215
Tuning the transformation and cellular signaling of 2D titanium carbide MXenes using a natural antioxidant
Malina T; Hamawandi B; Toprak MS; Chen L; Bjork J; Zhou J; Rosen J; Fadeel B
Article: ACS NANO. 2023;17(17):17451-17467
Exploiting Mass Spectrometry to Unlock the Mechanism of Nanoparticle-Induced Inflammasome Activation
Gupta G; Kaur J; Bhattacharya K; Chambers BJ; Gazzi A; Furesi G; Rauner M; Fuoco C; Orecchioni M; Delogu LG; Haag L; Stehr JE; Thomen A; Bordes R; Malmberg P; Seisenbaeva GA; Kessler VG; Persson M; Fadeel B
Article: NATURE NANOTECHNOLOGY. 2023;18(1):42-48
Graphene oxide elicits microbiome-dependent type 2 immune responses via the aryl hydrocarbon receptor
Peng G; Sinkko HM; Alenius H; Lozano N; Kostarelos K; Brautigam L; Fadeel B
Article: NATURE COMMUNICATIONS. 2022;13(1):3798
Biomarkers of nanomaterials hazard from multi-layer data
Fortino V; Kinaret PAS; Fratello M; Serra A; Saarimaki LA; Gallud A; Gupta G; Vales G; Correia M; Rasool O; Ytterberg J; Monopoli M; Skoog T; Ritchie P; Moya S; Vazquez-Campos S; Handy R; Grafstrom R; Tran L; Zubarev R; Lahesmaa R; Dawson K; Loeschner K; Larsen EH; Krombach F; Norppa H; Kere J; Savolainen K; Alenius H; Fadeel B; Greco D
Article: NATURE NANOTECHNOLOGY. 2018;13(7):537-543
Advanced tools for the safety assessment of nanomaterials
Fadeel B; Farcal L; Hardy B; Vazquez-Campos S; Hristozov D; Marcomini A; Lynch I; Valsami-Jones E; Alenius H; Savolainen K
Article: CHEM. 2018;4(2):334-358
Graphene Oxide Elicits Membrane Lipid Changes and Neutrophil Extracellular Trap Formation
Mukherjee SP; Lazzaretto B; Hultenby K; Newman L; Rodrigues AF; Lozano N; Kostarelos K; Malmberg P; Fadeel B
Article: SCIENCE SIGNALING. 2015;8(395):ra95
Dichotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phagocytosis and attenuation of innate immunity
Balasubramanian K; Maeda A; Lee JS; Mohammadyani D; Dar HH; Jiang JF; Croix CMS; Watkins S; Tyurin VA; Tyurina YY; Kloeditz K; Polimova A; Kapralova VI; Xiong Z; Ray P; Klein-Seetharaman J; Mallampalli RK; Bayir H; Fadeel B; Kagan VE
Article: NATURE NANOTECHNOLOGY. 2010;5(5):354-359
Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation
Kagan VE; Konduru NV; Feng W; Allen BL; Conroy J; Volkov Y; Vlasova II; Belikova NA; Yanamala N; Kapralov A; Tyurina YY; Shi J; Kisin ER; Murray AR; Franks J; Stolz D; Gou P; Klein-Seetharaman J; Fadeel B; Star A; Shvedova AA