Ulla Stenius
Professor
E-postadress: ulla.stenius@ki.se
Telefon: +46852487510
Besöksadress: Nobels väg 13, 17177 Stockholm
Postadress: C6 Institutet för miljömedicin, C6 Biokemisk toxikologi Stenius, 171 77 Stockholm
Om mig
- Ulla Stenius är professor i yrkestoxikologi sedan 2010 vid Institutet för miljömedicin. Under 2014-2022 var hon prefekt för samma institution.
Forskningsbeskrivning
- Projekt: Könsskillnader i känslighet för carcinogena ämnen
I detta projekt studeras könsskillnader och känslighet för tumöruppkomst av kemikalier. Ett syfte är att identifiera de cancerframkallande ämnen som uppvisar könsskillnader i carcinogen aktivitet. Ett annat mål är att identifiera verkningsmekanismer för dessa kemikalier. Av särskilt intresse är androgen receptors roll för manlig känslighet för carcinogener.
Finansieras av Forte och Formas
Projekt: Kvarts och cancer; ny typ av DNA-skada
Sedan flera år har en teori om hur kvarts orsakar mutationer varit dominerande. I detta projekt ska en alternativ typ av DNA-skademekanism studeras; kvartspartiklar kan ge dubbelsträngbrott och mikrokärnor genom aktivering av endonucleas G. Mekanismen ska karakteriseras vidare i experimentella modeller och dess relevans för canceruppkomst ska studeras. Projektet kan leda till en förenklad riskbedömning av kvarts och kanske också till ett sänkta gränsvärden i arbetslivet.
Finansieras av AFA försäkring
Utvalda publikationer
- Article: CARCINOGENESIS. 2019;40(4):580-591Zheng H; Jarvis IWH; Bottai M; Dreij K; Stenius U
- Article: BIOINFORMATICS. 2019;35(9):1553-1561Pyysalo S; Baker S; Ali I; Haselwimmer S; Shah T; Young A; Guo Y; Hogberg J; Stenius U; Narita M; Korhonen A
- Article: BIOINFORMATICS. 2017;33(24):3973-3981Baker S; Ali I; Silins I; Pyysalo S; Guo Y; Hogberg J; Stenius U; Korhonen A
- Article: CARCINOGENESIS. 2016;37(10):985-992Ali I; Hogberg J; Hsieh J-H; Auerbach S; Korhonen A; Stenius U; Silins I
Artiklar
- Article: BIOINFORMATICS. 2024;40(1):btae021Collins C; Baker S; Brown J; Zheng H; Chan A; Stenius U; Narita M; Korhonen A
- Article: CANCERS. 2023;15(3):865Zheng H; Stenius U; Hoegberg J
- Journal article: JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY. 2022;32(5):782Barron Cuenca J; Tirado N; Vikstrom M; Lindh CH; Stenius U; Leander K; Berglund M; Dreij K
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2021;129(6):67008Ali I; Dreij K; Baker S; Hogberg J; Korhonen A; Stenius U
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2021;548:91-97Wu R; Hogberg J; Adner M; Stenius U; Zheng H
- Article: PARTICLE AND FIBRE TOXICOLOGY. 2020;17(1):39Wu R; Hogberg J; Adner M; Ramos-Ramirez P; Stenius U; Zheng H
- Article: JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY. 2020;30(4):730-742Barron Cuenca J; Tirado N; Vikstrom M; Lindh CH; Stenius U; Leander K; Berglund M; Dreij K
- Article: BIOMEDICINE & PHARMACOTHERAPY. 2020;127:110112Ghalali A; Ye Z-W; Hogberg J; Stenius U
- Article: SCIENCE OF THE TOTAL ENVIRONMENT. 2019;695:133942Cuenca JB; Tirado N; Barral J; Ali I; Levi M; Stenius U; Berglund M; Dreij K
- Journal article: ENVIRONMENTAL EPIDEMIOLOGY. 2019;3(Supplement 1):22-23J B; N T; J B; C L; U S; M B; K D
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019;20(9):E2054-2054Raasmaja A; Stenius U; Ghalali A
- Article: JOURNAL OF BIOMEDICAL SEMANTICS. 2019;10(1):2Chiu B; Majewska O; Pyysalo S; Wey L; Stenius U; Korhonen A; Palmer M
- Article: CANCER RESEARCH. 2019;79(1):47-60Nilchian A; Johansson J; Ghalali A; Asanin ST; Santiago A; Rosencrantz O; Sollerbrant K; Vincent CT; Sund M; Stenius U; Fuxe J
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2018;355:43-51Brostrom JM; Ghalali A; Zheng H; Hogberg J; Stenius U; Littorin M; Tinnerberg H; Broberg K
- Article: CARCINOGENESIS. 2017;38(12):1196-1206Zheng H; Hogberg J; Stenius U
- Article: ENVIRONMENTAL SCIENCE & TECHNOLOGY. 2017;51(15):8805-8814Dreij K; Mattsson A; Jarvis IWH; Lim H; Hurkmans J; Gustafsson J; Bergvall C; Westerholm R; Johansson C; Stenius U
- Article: MOLECULAR CANCER RESEARCH. 2017;15(6):714-722Ghalali A; Martin-Renedo J; Hogberg J; Stenius U
- Article: PLOS ONE. 2017;12(3):e0173132Larsson K; Baker S; Silins I; Guo Y; Stenius U; Korhonen A; Berglund M
- Article: CARCINOGENESIS. 2016;37(12):1144-1151Ali I; Julin B; Glynn A; Hogberg J; Berglund M; Johansson J-E; Andersson S-O; Andren O; Giovannucci E; Wolk A; Stenius U; Akesson A
- Article: BIOINFORMATICS. 2016;32(3):432-440Baker S; Silins I; Guo Y; Ali I; Hogberg J; Stenius U; Korhonen A
- Article: TOXICOLOGY LETTERS. 2016;241:32-37Ali I; Guo Y; Silins I; Hogberg J; Stenius U; Korhonen A
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2015;287(3):222-231Brostrom JM; Ye Z-W; Axmon A; Littorin M; Tinnerberg H; Lindh CH; Zheng H; Ghalali A; Stenius U; Jonsson BAG; Hogberg J
- Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2015;239:164-173Al-Anati L; Viluksela M; Strid A; Bergman A; Andersson PL; Stenius U; Hogberg J
- Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2015;231:44-52Ali I; Damdimopoulou P; Stenius U; Halldin K
- Article: BIOINFORMATICS. 2015;31(7):1084-1092Kiela D; Guo Y; Stenius U; Korhonen A
- Article: ENVIRONMENTAL SCIENCE & TECHNOLOGY. 2015;49(5):3101-3109Lim H; Mattsson Å; Jarvis IWH; Bergvall C; Bottai M; Morales DA; Kummrow F; Umbuzeiro GA; Stenius U; Westerholm R; Dreij K
- Article: PLOS ONE. 2014;9(8):e104639Viluksela M; Heikkinen P; van der Ven LTM; Rendel F; Roos R; Esteban J; Korkalainen M; Lensu S; Miettinen HM; Savolainen K; Sankari S; Lilienthal H; Adamsson A; Toppari J; Herlin M; Finnila M; Tuukkanen J; Leslie HA; Hamers T; Hamscher G; Al-Anati L; Stenius U; Dervola K-S; Bogen I-L; Fonnum F; Andersson PL; Schrenk D; Halldin K; Hakansson H
- Article: TOXICOLOGY LETTERS. 2014;229(1):25-32Jarvis IWH; Bergvall C; Morales DA; Kummrow F; Umbuzeiro GA; Westerholm R; Stenius U; Dreij K
- Article: JOURNAL OF CHROMATOGRAPHY A. 2014;1355:100-106Lim H; Bergvall C; Jarvis I; Mattsson Å; Dreij K; Stenius U; Westerholm R
- Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2014;219:159-167Al-Anati L; Kadekar S; Hogberg J; Stenius U
- Article: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2014;55(6):510-517Umbuzeiro GA; Kummrow F; Morales DA; Alves DKM; Lim H; Jarvis IWH; Bergvall C; Westerholm R; Stenius U; Dreij K
- Article: CARCINOGENESIS. 2014;35(7):1547-1555Ghalali A; Wiklund F; Zheng H; Stenius U; Hogberg J
- Article: FRONTIERS IN PHARMACOLOGY. 2014;5:145Silins I; Korhonen A; Stenius U
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2013;266(3):408-418Jarvis IWH; Bergvall C; Bottai M; Westerholm R; Stenius U; Dreij K
- Article: TOXICOLOGIC PATHOLOGY. 2012;40(8):1160-1168Kadekar S; Peddada S; Silins I; French JE; Hogberg J; Stenius U
- Article: PLOS ONE. 2012;7(8):e43209Kadekar S; Silins I; Korhonen A; Dreij K; Al-Anati L; Hogberg J; Stenius U
- Article: INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT. 2012;8(3):412-417Silins I; Korhonen A; Hogberg J; Stenius U
- Article: TOXICOLOGICAL SCIENCES. 2012;127(1):66-75Ali I; Damdimopoulou P; Stenius U; Adamsson A; Makela SI; Akesson A; Berglund M; Hakansson H; Halldin K
- Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2012;25(4):862-872Niziolek-Kierecka M; Dreij K; Lundstedt S; Stenius U
- Article: PLOS ONE. 2012;7(4):e33427Korhonen A; Seaghdha DO; Silins I; Sun L; Hogberg J; Stenius U
- Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2012;40(3):867-875Miraglia E; Hogberg J; Stenius U
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;415(4):613-618Ye Z-W; Ghalali A; Hogberg J; Stenius U
- Article: BIOINFORMATICS. 2011;27(22):3179-3185Guo Y; Korhonen A; Silins I; Stenius U
- Article: CHEMOSPHERE. 2011;85(9):1423-1429Stenberg M; Hamers T; Machala M; Fonnum F; Stenius U; Lauy A-A; van Duursen MBM; Westerink RHS; Fernandes ECA; Andersson PL
- Article: BMC BIOINFORMATICS. 2011;12:69Guo Y; Korhonen A; Liakata M; Silins I; Hogberg J; Stenius U
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2010;249(2):166-177Al-Anati L; Hogberg J; Stenius U
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2010;118(10):1389-1394Ali I; Penttinen-Damdimopoulou PE; Makela SI; Berglund M; Stenius U; Akesson A; Hakansson H; Halldin K
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(36):27900-27910Mistafa O; Ghalali A; Kadekar S; Hogberg J; Stenius U
- Article: TOXINS. 2010;2(6):1279-1299Al-Anati L; Essid E; Stenius U; Beuerlein K; Schuh K; Petzinger E
- Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2009;182(2-3):191-198Al-Anati L; Hogberg J; Stenius U
- Article: BIOCHEMICAL PHARMACOLOGY. 2009;78(9):1115-1126Mistafa O; Stenius U
- Article: BMC BIOINFORMATICS. 2009;10:303Korhonen A; Silins I; Sun L; Stenius U
- Article: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2009;50(4):337-348Mattsson A; Lundstedt S; Stenius U
- Article: TOXICOLOGICAL SCIENCES. 2008;102(2):232-240Malmlof M; Paajarvi G; Hogberg J; Stenius U
- Article: MOLECULAR CARCINOGENESIS. 2008;47(4):301-309Paajarvi G; Jernstrom B; Seidel A; Stenius U
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2008;365(1):131-136Mistafa O; Hoegberg J; Stenius U
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(4):2288-2296Malmlof M; Roudier E; Hogberg J; Stenius U
- Article: MOLECULAR CANCER THERAPEUTICS. 2006;5(11):2706-2715Roudier E; Mistafa O; Stenius U
- Article: FOOD AND CHEMICAL TOXICOLOGY. 2006;44(9):1552-1561Silins I; Hogberg J; Stenius U
- Article: FASEB JOURNAL. 2005;18(15):476-478Pääjärvi G; Roudier E; Crisby M; Högberg J; Stenius U
- Article: CARCINOGENESIS. 2005;26(1):201-208Pääjärvi G; Viluksela M; Pohjanvirta R; Stenius U; Högberg J
- Article: ARCHIVES OF TOXICOLOGY. 2004;78(9):540-548Silins I; Stenius U; Högberg J
- Article: CANCER LETTERS. 2004;207(2):149-155Finnberg N; Stenius U; Högberg J
- Article: CARCINOGENESIS. 2004;25(1):113-122Finnberg N; Silins I; Stenius U; Högberg J
- Article: CARCINOGENESIS. 2003;24(6):1077-1083Silins I; Nordstrand M; Högberg J; Stenius U
- Article: CARCINOGENESIS. 2001;22(12):2023-2031Silins I; Finnberg N; Ståhl A; Högberg J; Stenius U
- Journal article: HEPATOLOGY. 2001;33(2):480-481Högberg J; Stenius U
- Article: TOXICOLOGICAL SCIENCES. 2000;54(1):95-103Finnberg N; Stenius U; Högberg J
- Article: EUROPEAN JOURNAL OF CANCER. 2000;36(1):106-112van Gijssel HE; Stenius U; Mulder GJ; Meerman JHN
- Article: CELL BIOLOGY AND TOXICOLOGY. 1999;15(1):31-39Lennartsson P; Stenius U; Högberg J
- Journal article: CARCINOGENESIS. 1999;20(1):181-182Stenius U; Högberg J
- Article: CELL BIOLOGY AND TOXICOLOGY. 1999;15(4):239-247Nordstrand M; Stenius U
- Article: JOURNAL OF MOLECULAR HISTOLOGY. 1999;31(1):75-78Martens U; Stenius U
- Article: CANCER LETTERS. 1998;134(1):103-109Stenius U; Högberg J
- Journal article: TOXICOLOGY LETTERS. 1998;95:180Stenius U; Lennartsson P; Högberg J
- Article: CARCINOGENESIS. 1998;19(7):1231-1237Lennartsson P; Högberg J; Stenius U
- Article: TOXICOLOGY IN VITRO. 1998;12(3):279-285Stenius U; Stahl A; Hogberg J
- Article: CANCER LETTERS. 1996;104(1):21-26Martens U; Lennartsson P; Högberg J; Stenius U
- Article: TOXICOLOGY IN VITRO. 1995;9(6):937-943Warholm M; Stenius U; Ståhl A; Högberg J
- Journal article: CARCINOGENESIS. 1994;15(8):1561-1566Stenius U; Warholm M; Martens U; Högberg J
- Journal article: CANCER LETTERS. 1993;68(2-3):149-157Stenius U; Warholm M; Högberg J
- Journal article: CARCINOGENESIS. 1993;14(1):159-161Stenius U
- Journal article: CARCINOGENESIS. 1992;13(10):1751-1758Garberg P; Stenius U; Nilsson K; Högberg J
- Journal article: CARCINOGENESIS. 1990;11(1):69-73Stenius U; Rubin K; Gullberg D; Högberg J
- Journal article: CARCINOGENESIS. 1989;10(3):593-599Stenius U; Warholm M; Rannug A; Walles S; Lundberg I; Högberg J
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Alla övriga publikationer
- Book chapter: LECTURE NOTES IN COMPUTER SCIENCE. 2015;p. 89-98Korhonen A; Guo Y; Baker S; Yetisgen-Yildiz M; Stenius U; Narita M; Lio P
- Review: TOXICOLOGY. 2014;321:27-39Jarvis IWH; Dreij K; Mattsson Å; Jernström B; Stenius U
- Review: BIOINFORMATICS. 2013;29(11):1440-1447Guo Y; Silins I; Stenius U; Korhonen A
- Review: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS. 2009;12(2):107-123Smolders R; Schramm K-W; Stenius U; Grellier J; Kahn A; Trnovec T; Sram R; Schoeters G
- Review: EXS. 2009;99:181-208Högberg J; Silins I; Stenius U
- Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 2008;28(4-5):392-401Mattsson A; Malmlof M; Seidel A; Stenius U; Jernstrom B
- Meeting abstract: EPIDEMIOLOGY. 2006;17(6):S299Hogberg J; Stenius U; Paajarvi G
- Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 2004;24(4-5):537-548Pääjärvi G; Jernström B; Stenius U; Seidel A
- Published conference paper: TOXICOLOGY IN VITRO. 1998;12(5):607-610Lennartsson P; Stenius U; Hogberg J
- Published conference paper: ATLA-ALTERNATIVES TO LABORATORY ANIMALS. 1996;24(3):393-397Stenius U; Martens U; Hogberg J
- Other: CARCINOGENESIS. 1995;16(8):1683-1686Stenius U; Högberg J
- Book chapter: ANTICARCINOGENESIS AND RADIATION PROTECTION 2. 1991;p. 151-154Högberg J; Stenius U
Forskningsbidrag
- Ny typ av indirekt skada på DNA kan vara avgörande för hur kvarts ger cancerAFA Försäkring1 July 2023 - 30 June 2026
- Swedish Research Council for Environment Agricultural Sciences and Spatial Planning1 January 2023 - 31 December 2025Men have higher cancer incidences than women. Lifetime risk for men is 50% and for women 30% and an incidence quote of 1.8 for men/women has been shown for cancer in non-sex organs. Calculations suggest that a third of all cancer cases should be possible to eliminate if causes were known and could be eliminated. Further support for differences is that men have worse survival statistics and that boys have worse cancer prognosis. We have found that skin carcinogens inactivate androgen receptor (AR) in human stem cells. In the present project we will study if carcinogen-induced inactivation of androgen receptor (AR) in human stem cells can explain men’s susceptibility to cancer, and in particular the high incidence for older men. We will 1) investigate how environmental carcinogens inactivate AR, 2) analyze the consequences of AR inactivation concerning DNA damage and repair, 3) study if carcinogens interact with age-dependent decline in testosterone levels and increase DNA damage and mutation burden, and 4) analyze differences in tumor-specific mutational burden between genders. Our study will hopefully explain a major risk factor behind melanoma and perhaps also men´s cancer susceptibility for several other tumors. Our study may also suggest tools to decrease men´s cancer incidence, as well as the total cancer incidence, via a development of new risk assessment strategies.
- Swedish Research Council for Health Working Life and Welfare1 January 2019 - 31 December 2021
Anställningar
- Professor, Institutet för miljömedicin, Karolinska Institutet, 2010-
Examina och utbildning
- Docent, Toxikologi, Karolinska Institutet, 1999