Ulla Stenius

Ulla Stenius

Professor | Docent
Telephone: +46852487510
Visiting address: Nobels väg 13, 17177 Stockholm
Postal address: C6 Institutet för miljömedicin, C6 Biokemisk toxikologi Stenius, 171 77 Stockholm

About me

  • Ulla Stenius is a Professor of Occupational Toxicology since 2010 at the Institute of Environmental Medicine (IMM). 2014-2022 she was appointed Head/Director of the same department.

Research

  • Chemical carcinogenesis, prevention and risk assessment We analyze sex differences in response to carcinogens and the carcinogenic effects of silica. The goal of the projects is to improve the scientific base for risk assessment. The CRAB- and Lion-projects investigates a novel approach to cancer risk assessment and cancer discovery which could greatly assist risk assessors with the management of large textual data and aid knowledge discovery. Projects - Using text mining to aid cancer risk assessment - Gender differences in carcinogenesis - Cancer risk of low dose exposure for silica Project: Gender differences in carcinogenesis In this project we investigate sex differences in response to carcinogens. A main objective is to identify chemicals exhibiting sexual dimorphism in their response. Another objective is to identify mode of action for these chemicals. Of special interest is the role of androgen receptor for male susceptibility to carcinogens. Financed by Forte and Formas Project: Cancer risk associated with low dose silica exposure The overall aim of this project is to characterize mechanisms for silica-induced inflammation and silica-induced DNA damage at low doses. In cell studies we find that silica particles induce inflammation and DNA damage in lower doses than previously employed. The finding that this occurs in epithelial cells suggests that this may have a direct bearing on silica-related lung cancer. Our data challenges the mode of action for silica carcinogenesis suggested by IARC and suggests that cancer should be seen not as a sequel of silicosis but rather as process that develops in parallel with silicosis. In this project, an alternative type of DNA damage mechanism will be studied
  • quartz particles can cause double strand breaks and micronuclei through activation of endonuclease G. The mechanism will be further characterized in experimental models and its relevance to cancer development investigated. The project may lead to a simplified risk assessment of quartz and perhaps also to a lowering of occupational exposure limits. Financed by AFA försäkring

Selected publications

Articles

All other publications

Grants

Employments

  • Professor, Institute of Environmental Medicine, Karolinska Institutet, 2010-

Degrees and Education

  • Docent, Karolinska Institutet, 1999

Supervisor

  • Sandeep Kadekar, Gender differences in chemical carcinogenesis, https://openarchive.ki.se/xmlui/handle/10616/41811

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