Stephan Mielke

Publikationer
Populärvetenskap och samverkan

Artiklar

Article: JOURNAL OF CLINICAL ONCOLOGY. 2025;43(24):2671-2678
Lisocabtagene Maraleucel Versus Standard of Care for Second-Line Relapsed/Refractory Large B-Cell Lymphoma: 3-Year Follow-Up From the Randomized, Phase III TRANSFORM Study.
Kamdar M; Solomon SR; Arnason J; Johnston PB; Glass B; Bachanova V; Ibrahimi S; Mielke S; Mutsaers P; Hernandez-Ilizaliturri F; Izutsu K; Morschhauser F; Lunning M; Chow VA; Montheard S; Santamaria J; Colicino S; Ogasawara K; Stepan L; Liu FF; Abramson JS
Article: BONE MARROW TRANSPLANTATION. 2025;:1-8
Allogeneic hematopoietic cell transplantation for older patients with Philadelphia-positive acute lymphoblastic leukemia. A study by the Acute Leukemia Working Party of the EBMT
Giebel S; Labopin M; Swoboda R; Blaise D; Yakoub-Agha I; Nguyen S; Wagner-Drouet EM; Castilla-Llorente C; Kottaridis P; Schroeder T; Fanin R; Passweg J; Versluis J; Crawley C; Gabellier L; Mielke S; Poire X; Nur E; Vaz CP; Eder M; Nozzoli C; Dreger P; Peric Z; Mohty M; Ciceri F
Article: BONE MARROW TRANSPLANTATION. 2025;60(7):956-963
The impact of ABO compatibility on allogeneic hematopoietic cell transplantation outcomes: a contemporary and comprehensive study from the transplant complications working party of the EBMT
Guven M; Peczynski C; Boreland W; Blaise D; Peffault de Latour R; Yakoub-Agha I; Gedde-Dahl T; Salmenniemi U; Forcade E; Passweg J; Chevallier P; Sandrine L; Mielke S; Broers A; Ceballos P; Byrne J; Castilla-Llorente C; Maertens J; Huynh A; Cerretti R; Bulabois CE; van Gorkom G; Crawley C; Graham C; Mussetti A; Schoemans H; Penack O; Moiseev I; Peric Z
Article: BONE MARROW TRANSPLANTATION. 2025;60(5):603-616
Tuberculosis after hematopoietic cell transplantation: retrospective study on behalf of the infectious diseases working party of the EBMT
Drozd-Sokolowska J; Tridello G; Verheggen I; Karakukcu M; Ben Abdeljelil N; Colita A; Aljurf M; Kroeger N; Ozturk G; Passweg J; Gambella M; Popova M; Lopez Corral L; Tanase A; Piekarska A; Al Zahrani M; Ar MC; Basak G; Broers AEC; Carlson K; Clark A; Faraci M; Jindra P; Krivan G; Ducastelle Lepretre S; Mielke S; Niederland J; Pane F; Patrick K; Snowden JA; Yavasoglu I; Zecca M; Waszczuk-Gajda A; Wendel L; Knelange N; de la Camara R; Gil L; Mikulska M; Averbuch D; Styczynski J
Journal article: TRANSPLANTATION AND CELLULAR THERAPY. 2025;31(2):s208-s209
Circulating Tumor DNA (ctDNA) As an Early Outcome Predictor in Patients (Pts) with Second-Line (2L) Large B-Cell Lymphoma (LBCL) after Lisocabtagene Maraleucel (liso-cel) Versus Standard of Care (SOC) Treatment (Tx) from the Phase 3, Randomized Transform Study
Stepan L; Ansari S; Okal A; Dell'Aringa J; Thompson EG; Crotta A; Chow VA; Abramson JS; Kamdar M; Solomon SR; Johnston PB; Glass B; Mutsaers P; Arnason J; Mielke S; Shadman M; Hernandez-Ilizaliturri F; Izutsu K; Bachanova V; Ibrahimi S; Chabon J; Kurtz D; Alizadeh AA; Peiser L
Article: BONE MARROW TRANSPLANTATION. 2025;60(2):211-219
Satisfactory outcomes following a second autologous hematopoietic cell transplantation for multiple myeloma in poor stem cell mobilizers: a retrospective study on behalf of the Chronic Malignancies Working Party of the EBMT
Sever M; Drozd-Sokolowska J; Gras L; Koster L; Folber F; Mielke S; Fenk R; Basak G; Apperley J; Byrne J; Rambaldi A; Ringhoffer M; Eder M; Trneny M; Blaise D; Lenhoff S; Isaksson C; Passweg J; Partanen A; Sakellari I; Schoenland S; Morris C; Beksac M; Raj K; Hayden PJ; McLornan DP
Article: LEUKEMIA. 2025;39(2):431-437
Graft-versus-host disease after anti-CD19 chimeric antigen receptor T-cell therapy following allogeneic hematopoietic cell transplantation: a transplant complications and paediatric diseases working parties joint EBMT study
Orti G; Peczynski C; Boreland W; O'Reilly M; von Bonin M; Balduzzi A; Besley C; Kalwak K; Ryhaenen S; Guengoer T; Wynn RF; Bader P; Mielke S; Blaise D; Amrolia P; Yakoub-Agha I; Calkoen F; Schubert M-L; Potter V; Pichler H; Kroeger N; Kwon M; Sengeloev H; Torrent A; Chalandon Y; van Gorkom G; Koenecke C; Graham C; Schoemans H; Moiseev I; Penack O; Peric Z
Article: AMERICAN JOURNAL OF HEMATOLOGY. 2025;100(1):38-51
Methotrexate Versus Mycophenolate Mofetil Prophylaxis in Allogeneic Hematopoietic Cell Transplantation for Chronic Myeloid Malignancies: A Retrospective Analysis on Behalf of the Chronic Malignancies Working Party of the EBMT
Luft T; Gras L; Koster L; Kroeger N; Schroeder T; Platzbecker U; Sockel K; de Latour RP; Stelljes M; Sengeloev H; Eder M; Blau IW; Dreger P; Yakoub-Agha I; Maertens J; Salmenniemi U; Bethge W; Mielke S; Kobbe G; Pouli A; de Wreede LC; Raj K; Drozd-Sokolowska J; Mclornan DP; Robin M
Article: TRANSPLANTATION AND CELLULAR THERAPY. 2025;31(1):14.e1-14.e10
Impact of the Type of Tyrosine Kinase Inhibitor (imatinib or dasatinib) Used Before allo-HCT on Outcome of Patients with Philadelphia-Positive Acute Lymphoblastic Leukemia. A Study on Behalf of the Acute Leukemia Working Party of the EBMT
Giebel S; Labopin M; Peric Z; Passweg J; Blaise D; Salmenniemi U; Beauvais D; Remenyi P; Chevallier P; Mielke S; Gedde-Dahl T; Cornelissen JJ; Balsat M; Bug G; Bazarbachi A; Brissot E; Nagler A; Ciceri F; Mohty M
Journal article: BLOOD. 2024;144:2333
Real-World Outcomes of CD19-Targeted CAR T-Cell Therapy in Adult and Pediatric Patients with B-Cell Acute Lymphoblastic Leukemia (B-ALL): Insights from the GoCART Coalition on Behalf of the PDWP, ALWP, and CTIWP of the EBMT
Ortiz-Maldonado V; Galimard J-E; Ottaviano G; Alonso-Saladrigues A; Farhan SY; Vuyyala S; Michel E; Imran F; Sanchez-Sierra N; Martinez-Cibrian N; Ryhaenen S; Mitchell R; Mielke S; Petersen SL; Sirvent A; Pabst T; Kuball J; Barba P; Perez A; Attarbaschi A; Nagler A; Perez-Simon JA; von Bonin M; Nicholson E; Beauvais D; Delgado J; Rives S; Kalwak K; Ciceri F; Ruggeri A; Balduzzi A; Giebel S
Journal article: BLOOD. 2024;144:965
Second Infusion of CAR T-Cells in Patients with Relapsed /Refractory B-Cell Acute Lymphoblastic Leukemia: Results from a Gocart Coalition Analysis on Behalf of the PDWP, ALWP, and Ctiwp of the EBMT
Rives S; Ottaviano G; Martinez-Cibrian N; Farhan SY; Vuyyala S; Galimard J-E; Michel E; Imran F; Sanchez-Sierra N; Mitchell R; Mielke S; Attarbaschi A; Petersen SL; Ryhanen Sr S; Bethge WA; Beauvais D; Zuckerman T; Perez-Martinez A; Kalwak K; Ciceri F; Ruggeri A; Delgado J; Giebel S; Balduzzi A; Alonso-Saladrigues A; Ortiz-Maldonado V
Journal article: BLOOD. 2024;144:2883.2
Resolve AML 001: An Adaptive Open-Label Multicentre Phase 1/2 Trial, to Determine the Recommended Phase 2 Dose of Cctx-001, and to Assess Safety, Tolerability, and Clinical Activity in Patients with r/r AML
Subklewe M; Boissel N; Mielke S; Barba P; Sala E; Deconinck E; Fiere O; Jaeger J; Vasseghi C; Deschamps M; Ferrand C; De Dreuzy E; Sainson R; Hasskarl J
Journal article: BLOOD. 2024;144:464
Autologous and Allogeneic Stem Cell Transplantation for Major T-Cell Lymphoma Entities: An Analysis of the EBMT Lymphoma Working Party
Shumilov E; Ngoya M; Berning P; Khvedelidze I; Carpenter B; Zeiser R; Broers AEC; Blaise D; Nur E; Mielke S; Nicholson E; Scheid C; Griskevicius L; Lenz G; Dreger P; Balari AS; Wulf G; Glass B; Bazarbachi A; Schmitz N
Journal article: BLOOD. 2024;144:600
Long-Term Outcomes of Allogeneic Hematopoietic Cell Transplantation for T-Cell Prolymphocytic Leukemia-a Study on Behalf of the Chronic Malignancies Working Party of the EBMT
Drozd-Sokolowska J; Gras L; Baaij L; Koster L; Nicholson E; Dreger P; Gedde-Dahl T; Mielke S; Salmenniemi U; Basak G; Chevallier P; Wulf G; Schetelig J; Johansson J-E; Nagler A; Quoc SN; Potter V; Sala E; Sandstedt AB; Koc Y; Zeiser R; van Gelder M; Jedrzejczak WW; Raj KK; Tournilhac O; Mclornan DP
Journal article: BLOOD. 2024;144:72
Circulating Tumor DNA (ctDNA) As an Early Outcome Predictor in Patients (pts) with Second-Line (2L) Large B-CellLymphoma (LBCL) after Lisocabtagene Maraleucel (liso-cel) Versus Standardof Care (SOC) Treatment (tx) from thePhase 3, Randomized Transform Study
Stepan L; Ansari S; Okal A; Dell'Aringa J; Thompson EG; Crotta A; Chow VA; Abramson JS; Kamdar M; Solomon SR; Johnston PB; Glass B; Mutsaers P; Arnason JE; Mielke S; Shadman M; Hernandez-Ilizaliturri F; Izutsu K; Bachanova SV; Ibrahimi S; Chabon J; Kurtz D; Alizadeh AA; Peiser L
Journal article: BLOOD. 2024;144:4387
Lisocabtagene Maraleucel (liso-cel) in Patients (pts) with Relapsed or Refractory (R/R) Follicular Lymphoma (FL): Transcend FL 2-Year Follow-up
Nastoupil L; Dahiya S; Palomba ML; Garcia-Sancho AM; Reguera JL; Kuruvilla J; Jaeger U; Cartron G; Izutsu K; Dreyling M; Kahl BS; Ghesquieres H; Ardeshna K; Goto H; Barbui AM; Abramson JS; Borchmann P; Fleury I; Mielke S; Skarbnik AP; Kamdar M; Karmali R; Viardot A; Farazi T; Kao GSH; Vedal M; Nishii R; Papuga J; Kumar J; Morschhauser F
Journal article: BLOOD. 2024;144:112
"Real World" Outcome of Hematopoietic Stem Cell Transplantation after CAR19 T Cell Therapy in Children and Adults with B-ALL: A Gocart Coalition Study on Behalf of the PDWP, ALWP, and Ctiwp of the EBMT
Ottaviano G; Alonso-Saladrigues A; Ortiz-Maldonado V; Galimard J-E; Farhan SY; Vuyyala S; Michel E; Imran F; Martinez-Cibrian N; Ryhanen S; Attarbaschi A; Mielke S; Kuball J; Martinez AP; Beguin Y; Nagler A; Sirvent A; Petersen SL; Barba P; Marsal J; Delgado J; Kalwak K; Ciceri F; Ruggeri A; Giebel S; Rives S; Balduzzi A
Article: EBIOMEDICINE. 2024;109:105385
Real-world assessment of immunogenicity in immunocompromised individuals following SARS-CoV-2 mRNA vaccination: a two-year follow-up of the prospective clinical trial COVAXID
Chen P; Bergman P; Blennow O; Hansson L; Mielke S; Nowak P; Gao Y; Soderdahl G; Osterborg A; Smith CIE; Vesterbacka J; Wullimann D; Cuapio A; Akber M; Bogdanovic G; Muschiol S; Aberg M; Lore K; Chen MS; Ljungman P; Buggert M; Aleman S; Ljunggren H-G
Article: BONE MARROW TRANSPLANTATION. 2024;59(10):1402-1412
Adenovirus infections after allogeneic hematopoietic cell transplantation in children and adults: a study from the Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation
Styczynski J; Tridello G; Knelange N; Wendel L; Ljungman P; Mikulska M; Gil L; Cesaro S; Averbuch D; von dem Borne P; Xhaard A; Mielke S; Neven B; Snowden JA; Dalle J-H; Rubio MT; Crawley C; Maertens J; Kuball J; Chevallier P; Michel G; Gabriel M; Burns D; Wynn RF; Renard C; Blijlevens N; Jubert C; Gedde-Dahl T; Collin M; Labussiere-Wallet H; Kalwak K; Broers AEC; Yakoub-Agha I; Itala-Remes M; de la Camara R
Journal article: CLINICAL LYMPHOMA MYELOMA & LEUKEMIA. 2024;24:s212
Impact of Bridging Therapy (BT) on Lisocabtagene Maraleucel (liso-cel) as Second-Line (2L) or Later (2L+) Treatment of R/R Follicular Lymphoma (FL) in the Phase 2, Open-Label TRANSCEND FL Study
Dahiya S; Hirayama AV; Schuster SJ; Ortega JLR; Morschhauser F; Garcia-Sancho AM; Kuruvilla J; Izutsu K; Barbui AM; Borchmann P; Mielke S; Cartron G; Ghesquieres H; Goto H; Varadarajan I; Kamdar M; Isufi I; Farazi T; Kao GSH; Vedal M; Bhatnagar R; Nishii R; Papuga J; Palomba ML
Journal article: CLINICAL LYMPHOMA MYELOMA & LEUKEMIA. 2024;24:s462-s463
ABCL-193 Impact of Bridging Therapy (BT) on Lisocabtagene Maraleucel (liso-cel) as Second-Line (2L) or Later (2L+) Treatment of R/R Follicular Lymphoma (FL) in the Phase 2, Open-Label TRANSCEND FL Study
Dahiya S; Hirayama AV; Schuster SJ; Ortega JLR; Morschhauser F; Garcia-Sancho AM; Kuruvilla J; Izutsu K; Barbui AM; Borchmann P; Mielke S; Cartron G; Ghesquieres H; Goto H; Varadarajan I; Kamdar M; Isufi I; Farazi T; Kao GSH; Vedal M; Bhatnagar R; Nishii R; Papuga J; Palomba ML
Journal article: ANNALS OF ONCOLOGY. 2024;35:s489-s490
Updated results from BNT211-01 (NCT04503278), an ongoing, first-in-human, phase I study evaluating safety and efficacy of CLDN6 CAR T cells and a CLDN6-encoding mRNA vaccine in patients with relapsed/refractory CLDN6+solid tumors
Haanen JBAG; Mackensen A; Schultze-Florey C; Alsdorf W; Wagner-Drouet E; Heudobler D; Borchmann P; Busse A; Mielke S; Bins S; Ungerechts G; Bokemeyer C; Klobuch S; Kutsch N; Mueller F; Desuki A; Zhong W; Preussner L; Tuereci O; Sahin U
Article: AMERICAN JOURNAL OF HEMATOLOGY. 2024;99(9):1732-1745
Comparable relapse incidence after unrelated allogeneic stem cell transplantation with post-transplant cyclophosphamide versus conventional anti-graft versus host disease prophylaxis in patients with acute myeloid leukemia: A study on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Nagler A; Ngoya M; Galimard J-E; Labopin M; Blau IW; Kroeger N; Gedde-Dahl T; Schroeder T; Burns D; Salmenniemi U; Rambaldi A; Choi G; de Latour RP; Vydra J; Sengeloev H; Eder M; Mielke S; Forcade E; Kulagin A; Ciceri F; Mohty M
Article: LEUKEMIA. 2024;38(9):1985-1991
Improved outcome of COVID-19 over time in patients treated with CAR T-cell therapy: Update of the European COVID-19 multicenter study on behalf of the European Society for Blood and Marrow Transplantation (EBMT) Infectious Diseases Working Party (IDWP) and the European Hematology Association (EHA) Lymphoma Group
Spanjaart AM; Ljungman P; Tridello G; Schwartz J; Martinez-Cibrian N; Barba P; Kwon M; Lopez-Corral L; Martinez-Lopez J; Ferra C; Di Blasi R; Ghesquieres H; Mutsaers P; Calkoen F; Jak M; van Doesum J; Vermaat JSP; van der Poel M; Maertens J; Gambella M; Metafuni E; Ciceri F; Saccardi R; Nicholson E; Tholouli E; Matthew C; Potter V; Bloor A; Besley C; Roddie C; Wilson K; Nagler A; Campos A; Petersen SL; Folber F; Bader P; Finke J; Kroger N; Knelange N; de la Camara R; Kersten MJ; Mielke S
Article: CANCER. 2024;130(15):2642-2651
Prognostic impact of number of induction courses to attain complete remission in patients with acute myeloid leukemia transplanted with either a matched sibling or human leucocyte antigen 10/10 or 9/10 unrelated donor: An Acute Leukemia Working Party European Society for Blood and Marrow Transplantation study
Loke J; Labopin M; Craddock C; Socie G; Gedde-Dahl T; Blaise D; Forcade E; Salmenniemi U; Huynh A; Versluis J; Yakoub-Agha I; Labussiere-Wallet H; Maertens J; Passweg J; Bulabois CE; Gabellier L; Mielke S; Castilla-Llorente C; Deconinck E; Brissot E; Nagler A; Ciceri F; Mohty M
Article: NATURE MEDICINE. 2024;30(8):2199-2207
Lisocabtagene maraleucel in follicular lymphoma: the phase 2 TRANSCEND FL study
Morschhauser F; Dahiya S; Palomba ML; Garcia-Sancho AM; Reguera-Ortega JL; Kuruvilla J; Jaeger U; Cartron G; Izutsu K; Dreyling M; Kahl B; Ghesquieres H; Ardeshna K; Goto H; Barbui AM; Abramson JS; Borchmann P; Fleury I; Mielke S; Skarbnik A; de Vos S; Kamdar M; Karmali R; Viardot A; Farazi T; Fasan O; Lymp J; Vedal M; Nishii R; Avilion A; Papuga J; Kumar J; Nastoupil LJ
Article: BLOOD. 2024;144(3):323-333
Alternative donor transplantation for severe aplastic anemia: a comparative study of the SAAWP EBMT
Montoro J; Eikema D-J; Tuffnell J; Potter V; Kalwak K; Halkes CJM; Kulagin A; Collin M; Wynn RF; Robinson S; Nicholson E; Sengeloev H; Clay J; Halahleh K; Skorobogatova E; Sanz J; Passweg J; Mielke S; Ryhaenen S; Carpenter B; Gedde-Dahl T; Tholouli E; Fanin R; Lewalle P; Kulasekararaj A; Risitano A; de Latour RP
Article: BONE MARROW TRANSPLANTATION. 2024;59(7):1012-1021
Post-transplant cyclophosphamide, calcineurin inhibitor, and mycophenolate mofetil compared to anti-thymocyte globulin, calcineurin inhibitor, and methotrexate combinations as graft-versus-host disease prophylaxis post allogeneic stem cell transplantation from sibling and unrelated donors in patients with acute myeloid leukemia: a study on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Nagler A; Labopin M; Swoboda R; Schroeder T; Hamladji R-M; Griskevicius L; Salmenniemi U; Rambaldi A; Mielke S; Kulagin A; Passweg J; Luft T; Gedde-Dahl T; Forcade E; Helbig G; Stelljes M; Castilla-Llorente C; Spyridonidis A; Brissot E; Ciceri F; Mohty M
Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2024;42(16_suppl):7068
Impact of bridging therapy (BT) on lisocabtagene maraleucel (liso-cel) treatment in patients (pt) with R/R follicular lymphoma (FL).
Reguera JL; Garcia-Sancho AM; Kuruvilla J; Izutsu K; Barbui AM; Peter B; Mielke S; Palomba ML; Cartron G; Ghesquieres H; Goto H; Varadarajan I; Farazi T; Kao GSH; Vedal M; Nishii R; Papuga J; Morschhauser F
Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2024;42(16_suppl):7013
Lisocabtagene maraleucel (liso-cel) vs standard of care (SOC) with salvage chemotherapy (CT) followed by autologous stem cell transplantation (ASCT) as second-line (2L) treatment in patients (pt) with R/R large B-cell lymphoma (LBCL): 3-year follow-up (FU) from the randomized, phase 3 TRANSFORM study.
Kamdar MK; Solomon SR; Arnason J; Johnston PB; Glaß B; Bachanova V; Ibrahimi S; Mielke S; Mutsaers P; Hernandez-Ilizaliturri FJ; Izutsu K; Morschhauser F; Lunning MA; Chow VA; Santamaria J; Colicino S; Ogasawara K; Stepan L; Abramson JS
Article: LEUKEMIA. 2024;38(5):1156-1163
ATG or post-transplant cyclophosphamide to prevent GVHD in matched unrelated stem cell transplantation?
Penack O; Abouqateb M; Peczynski C; Boreland W; Kroeger N; Stelljes M; Gedde-Dahl T; Blau IW; Schroeder T; Salmenniemi U; Kulagin A; de Latour RP; Mielke S; Zeiser R; Moiseev I; Schoemans H; Koenecke C; Peric Z
Article: JOURNAL OF CLINICAL ONCOLOGY. 2024;42(12):1378-1390
Patient-Specific Measurable Residual Disease Markers Predict Outcome in Patients With Myelodysplastic Syndrome and Related Diseases After Hematopoietic Stem-Cell Transplantation
Tobiasson M; Pandzic T; Illman J; Nilsson L; Westrom S; Ejerblad E; Olesen G; Bjorklund A; Olsnes Kittang A; Werlenius O; Lorentz F; Rasmussen B; Cammenga J; Weber D; Lindholm C; Wiggh J; Dimitriou M; Moen AE; Lundstrom LY; von Bahr L; Baltzer-Sollander K; Jadersten M; Kytola S; Walldin G; Ljungman P; Groenbaek K; Mielke S; Jacobsen SEW; Ebeling F; Cavelier L; Smidstrup Friis L; Dybedal I; Hellstrom-Lindberg E
Article: CELL HOST & MICROBE. 2024;32(2):156-161.e3
Memory T cells effectively recognize the SARS-CoV-2 hypermutated BA.2.86 variant
Muller TR; Gao Y; Wu J; Ribeiro O; Chen P; Bergman P; Blennow O; Hansson L; Mielke S; Nowak P; Vesterbacka J; Akber M; Soderdahl G; Smith CIE; Lore K; Chen MS; Ljungman P; Ingelman-Sundberg HM; Ljunggren H-G; Osterborg A; Sette A; Grifoni A; Aleman S; Buggert M
Journal article: TRANSPLANTATION AND CELLULAR THERAPY. 2024;30(2):s258-s259
Post-Transplant Cyclophosphamide, Tacrolimus (TAC) or Cyclosporine a and Mycophenolate Mofetil Versus Anti-Thymocyte Globulin, TAC, Methotrexate Combinations As Graft-versus-Host Disease Prophylaxis Post Allogeneic Stem Cell Transplantation from Sibling and Unrelated Donors in Patients with Acute Myeloid Leukemia: a Study on Behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Nagler A; Labopin M; Schroeder T; Hamladji R-M; Griskevicius L; Rambaldi A; Mielke S; Kulagin A; Passweg J; Dreger P; Gedde-Dahl T; Forcade E; Helbig G; Stelljes M; Castilla-Llorente C; Spyridonidis A; Savani BN; Brissot E; Ciceri F; Mohty M
Journal article: TRANSPLANTATION AND CELLULAR THERAPY. 2024;30(2):s46-s47
Relapse Incidence Post Unrelated Allogeneic Stem Cell Transplantation with Post-Transplant Cyclophosphamide (PTCy) in Patients with Acute Myeloid Leukemia: A Study on Behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Nagler A; Ngoya M; Galimard J-E; Labopin M; Blau W-I; Kroger N; Gedde-Dahl T; Schroeder T; Burns D; Salmenniemi U; Rambaldi A; Choi G; de Latour RP; Vydra J; Sengeloev H; Eder M; Mielke S; Forcade E; Bondarenko SN; Ciceri F; Mohty M
Article: ECLINICALMEDICINE. 2024;67:102393
Influence of invasive aspergillosis during acute leukaemia treatment on survival after allogeneic stem cell transplantation: a prospective study of the EBMT Infectious Diseases Working Party
Penack O; Tridello G; Salmenniemi U; Martino R; Khanna N; Perruccio K; Fagioli F; Richert-Przygonska M; Labussiere-Wallet H; Maertens J; Jubert C; Aljurf M; Pichler H; Krivan G; Kunadt D; Popova M; Gabriel M; Calore E; Blau IW; Benedetti F; Itala-Remes M; de Kort E; Russo D; Faraci M; Menard A-L; von dem Borne P; Poire X; Yesilipek A; Gozdzik J; Yegin ZA; Yanez L; Facchini L; Van Gorkom G; Thurner L; Kocak U; Sampol A; Zuckerman T; Bierings M; Mielke S; Ciceri F; Wendel L; Knelange N; Mikulska M; Averbuch D; Styczynski J; de la Camara R; Cesaroaq S
Article: TRANSPLANTATION AND CELLULAR THERAPY. 2024;30(1):95.e1-95.e10
Thiotepa-Based Regimens Are Valid Alternatives to Total Body Irradiation-Based Reduced-Intensity Conditioning Regimens in Patients with Acute Lymphoblastic Leukemia: A Retrospective Study on Behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Battipaglia G; Labopin M; Mielke S; Ruggeri A; Ozkurt ZN; Bourhis JH; Rabitsch W; Yakoub-Agha I; Grillo G; Sanz J; Arcese W; Novis Y; Fegueux N; Spyridonidis A; Giebel S; Nagler A; Ciceri F; Mohty M
Journal article: OPEN FORUM INFECTIOUS DISEASES. 2023;10(Supplement_2):ofad500.555
485. Improved Outcome of COVID-19 in CAR T Cell Treated Patients; results of a multicenter study on behalf of the European Society for Blood and Marrow Transplantation (EBMT) Infectious Diseases Working Party and the European Hematology Association (EHA) Lymphoma Group
Ljungman P; Spanjaart AM; Tridello G; Knelange N; de la Camara R; Kersten MJ; Mielke S
Journal article: BLOOD. 2023;142:237
Relapse Incidence Post Unrelated Allogeneic Stem Cell Transplantation with Post-Transplant Cyclophosphamide (PTCy) Versus Conventional Anti-Graft Versus Host Disease Prophylaxis in Patients with Acute Myeloid Leukemia: A Study on Behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Nagler A; Ngoya M; Galimard J-E; Labopin M; Blau IW; Kroeger N; Gedde-Dahl T; Schroeder T; Burns D; Salmenniemi U; Rambaldi A; Choi G; De latour RP; Vydra J; Sengeloev H; Eder M; Mielke S; Forcade E; Bondarenko S; Ciceri F; Mohty M
Journal article: BLOOD. 2023;142:895
Interindividual HLA Evolutionary Divergence in Single HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation for Malignant Hematological Disorders: A Report on Behalf of the Cellular Therapy and Immunobiology Working Party of the EBMT
Pagliuca S; Mooyaart J; Kroger N; Finke J; Potter V; Dreger P; Hilgendorf I; Bethge WA; De latour RP; Rambaldi A; Sengeloev H; Passweg J; Gedde-Dahl T; Burns D; Orchard K; Mielke S; Edinger M; Andreani M; Crivello P; Merli P
Journal article: BLOOD. 2023;142:3558
ATG or Post-Transplant Cyclophosphamide to Prevent Gvhd in Matched Unrelated Stem Cell Transplantation? - a Registry Analysis By the EBMT Transplant Complications Working Party
Penack O; Abouqateb M; Peczynski C; Boreland W; Kroeger N; Stelljes M; Gedde-Dahl T; Blau IW; Schroeder T; Salmenniemi U; Aleksandr KS; De Latour RP; Mielke S; Finke J; Moiseev IS; Schoemans H; Koenecke C; Peric Z
Journal article: BLOOD. 2023;142:2181
Post-Transplant Cyclophosphamide, Tacrolimus or Cyclosporine a and Mycophenolate Mofetil Compared to Anti-Thymocyte Globulin tacrolimus or Cyclosporine a and Methotrexate Combinations As Graft- versus -Host Disease Prophylaxis Post Allogeneic Stem Cell Transplantation from Sibling and Unrelated Donors in Patients with Acute Myeloid Leukemia: a Study on Behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Nagler A; Labopin M; Schroeder T; Hamladji R-M; Griskevicius L; Salmenniemi U; Rambaldi A; Mielke S; Aleksandr KS; Passweg JR; Dreger P; Gedde-Dahl T; Forcade E; Helbig G; Stelljes M; Castilla-Llorente C; Spyridonidis A; Savani BN; Brissot E; Ciceri F; Mohty M
Journal article: BLOOD. 2023;142:3592
Salvage Transplant Versus CAR-T Cell Therapy for Relapsed Multiple Myeloma
Gagelmann N; Garderet L; Iacobelli S; Koster L; Carotti A; Schoenland S; Galieni P; Daskalakis M; Roeloffzen W; Hunter H; Duchosal MA; Lenhoff S; Arat M; Wulf GG; Bolam S; Pastore D; Gedde-Dahl T; Richardson DS; Mielke S; Raj K; Drozd-Sokolowska J; Hayden PJ; McLornan DP
Journal article: BLOOD. 2023;142:602
TRANSCEND FL: Phase 2 Study Primary Analysis of Lisocabtagene Maraleucel as SecondLine Therapy in Patients with High-Risk Relapsed or Refractory Follicular Lymphoma
Morschhauser F; Dahiya S; Palomba ML; Garcia-Sancho AM; Reguera JL; Kuruvilla J; Jaeger U; Cartron G; Izutsu K; Dreyling M; Kahl BS; Ghesquieres H; Ardeshna K; Goto H; Barbui AM; Abramson JS; Borchmann P; Fleury I; Mielke S; Skarbnik A; de Vos S; Kamdar M; Karmali R; Viardot A; Farazi T; Fasan O; Lymp J; Vedal M; Nishii R; Avilion A; Papuga J; Nastoupil LJ
Journal article: BLOOD. 2023;142:2189
Graft-Versus-Host Disease after Anti-CD19 Chimeric Antigen Receptor T-Cell Infusion Post Allogeneic Hematopoietic Cell Transplantation: A Transplant Complications and Paediatric Disease Working Parties EBMT Joint Study
Orti G; Peczynski C; Koenecke C; Boreland W; O'Reilly M; Bornhaeuser M; Balduzzi A; Besley C; Kalwak K; Samppa RS; Gungor T; Wynn RF; Bader P; Mielke S; Blaise D; Amrolia P; Yakoub-Agha I; Calkoen FGJ; Schubert M-L; Potter V; Holter W; Kroeger N; Kwon M; Sengeloev H; Schoemans H; Moiseev IS; Penack O; Peric Z
Journal article: BLOOD. 2023;142:472
Conditioning Intensity in Patients Aged > 50 Years Undergoing Allogeneic Hematopoietic Cell Transplantation for Myelodysplastic Syndrom: A Study on Behalf of the Chronic Malignancies Working Party of the EBMT
Loukili NH; Luuk GS; Koster L; Blaise D; Gedde-Dahl T; Maertens J; De latour RP; Sengeloev H; Mielke S; Chevallier P; Passweg JR; Byrne JL; Salmenniemi U; Sirvent A; Guyotat D; Sica S; de Wreede LC; Onida F; Scheid C; Gurnari C; Drozd-Sokolowska J; Raj K; Robin M; McLornan DP; Yakoub-Agha I
Journal article: BLOOD. 2023;142:1047
Alternative Donor Transplantation for Severe Aplastic Anemia: A Comparative Study of the Saawp EBMT
Montoro J; Dirk-Jan ES; Joe TS; Potter V; Krzysztof KS; Stijn HS; Aleksandr KS; Matthew CPS; Robert WS; Stephen RJ; Emma NS; Sengeloev H; Jennifer CS; Khaled HS; Elena SS; Jakob PS; Mielke S; Samppa RS; Carpenter B; Gedde-Dahl T; Tholouli E; Fanin R; Philippe LS; Kulasekararaj A; Risitano AM; De Latour RP
Article: BLOOD. 2023;142(10):865-877
Immune effector cell-associated hematotoxicity: EHA/EBMT consensus grading and best practice recommendations
Rejeski K; Subklewe M; Aljurf M; Bachy E; Balduzzi A; Barba P; Bruno B; Benjamin R; Carrabba MG; Chabannon C; Ciceri F; Corradini P; Delgado J; Di Blasi R; Greco R; Houot R; Iacoboni G; Jager U; Kersten MJ; Mielke S; Nagler A; Onida F; Peric Z; Roddie C; Ruggeri A; Sanchez-Guijo F; Sanchez-Ortega I; Schneidawind D; Schubert M-L; Snowden JA; Thieblemont C; Topp M; Zinzani PL; Gribben JG; Bonini C; Sureda A; Yakoub-Agha I
Article: EBIOMEDICINE. 2023;94:104700
Real-world assessment of immunogenicity in immunocompromised individuals following SARS-CoV-2 mRNA vaccination: a one-year follow-up of the prospective clinical trial COVAXID
Chen P; Bergman P; Blennow O; Hansson L; Mielke S; Nowak P; Soderdahl G; oesterborg A; Smith CIE; Vesterbacka J; Wullimann D; Cuapio A; Akber M; Bogdanovic G; Muschiol S; aberg M; Lore K; Chen MS; Buggert M; Ljungman P; Aleman S; Ljunggren H-G
Article: SCIENCE ADVANCES. 2023;9(30):eadd6997
Loss of metabolic fitness drives tumor resistance after CAR-NK cell therapy and can be overcome by cytokine engineering
Li L; Mohanty V; Dou J; Huang Y; Banerjee PP; Miao Q; Lohr JG; Vijaykumar T; Frede J; Knoechel B; Muniz-Feliciano L; Laskowski TJ; Liang S; Moyes JS; Nandivada V; Basar R; Kaplan M; Daher M; Liu E; Li Y; Acharya S; Lin P; Shanley M; Rafei H; Marin D; Mielke S; Champlin RE; Shpall EJ; Chen K; Rezvani K
Article: SCIENCE TRANSLATIONAL MEDICINE. 2023;15(704):eadg9452
Additive effects of booster mRNA vaccination and SARS-CoV-2 Omicron infection on T cell immunity across immunocompromised states
Muller TRR; Sekine T; Trubach D; Niessl J; Chen P; Bergman P; Blennow O; Hansson L; Mielke S; Nowak P; Vesterbacka J; Akber M; Olofsson A; Hernandez SPA; Gao Y; Cai C; Soderdahl G; Smith CIE; Osterborg A; Lore K; Sallberg Chen M; Ljungman P; Ljunggren H-G; Karlsson ACC; Saini SK; Aleman S; Buggert M
Article: BONE MARROW TRANSPLANTATION. 2023;58(7):791-800
Matched related versus unrelated versus haploidentical donors for allogeneic transplantation in AML patients achieving first complete remission after two induction courses: a study from the ALWP/EBMT
Nagler A; Labopin M; Mielke S; Passweg J; Blaise D; Gedde-Dahl T; Cornelissen JJJ; Salmenniemi U; Yakoub-Agha I; Remenyi P; Socie G; van Gorkom G; Labussiere-Wallet H; Huang X-J; Rubio MT; Byrne J; Craddock C; Griskevicius L; Ciceri F; Mohty M
Journal article: HEMATOLOGICAL ONCOLOGY. 2023;41(S2):877-880
TRANSCEND FL: PHASE 2 STUDY RESULTS OF LISOCABTAGENE MARALEUCEL (LISO‐CEL) IN PATIENTS (PTS) WITH RELAPSED/REFRACTORY (R/R) FOLLICULAR LYMPHOMA (FL)
Morschhauser F; Dahiya S; Palomba ML; Garcia‐Sancho AM; Ortega JLR; Kuruvilla J; Jager U; Cartron G; Izutsu K; Dreyling M; Kahl B; Ghesquieres H; Ardeshna K; Goto H; Barbui AM; Abramson JS; Borchmann P; Fleury I; Mielke S; Farazi T; Fasan O; Lymp J; Vedal M; Nishii R; Avilion A; Papuga J; Nastoupil LJ
Article: BONE MARROW TRANSPLANTATION. 2023;58(6):710-716
Fludarabine/TBI 8 Gy versus fludarabine/treosulfan conditioning in patients with AML in first complete remission: a study from the Acute Leukemia Working Party of the EBMT
Bug G; Labopin M; Niittyvuopio R; Stelljes M; Reinhardt HC; Hilgendorf I; Kroeger N; Kaare A; Bethge W; Schaefer-Eckart K; Verbeek M; Mielke S; Carlson K; Bazarbachi A; Spyridonidis A; Savani BN; Nagler A; Mohty M
Journal article: JOURNAL OF IMMUNOLOGY. 2023;210(Supplement_1):75.16
Anamnestic expansion of Omicron-reactive CD8+ T cells after booster SARS-CoV-2 mRNA vaccination across different immunocompromised states
Müller TR; Sekine T; Trubach D; Niessl J; Olofsson A; Gao Y; Cai C; Nowak P; Blennow O; Hansson L; Mielke S; Bergman P; Ljunggren H-G; Karlsson AC; Saini SK; Aleman S; Buggert M
Article: BLOOD. 2023;141(14):1675-1684
Lisocabtagene maraleucel as second-line therapy for large B-cell lymphoma: primary analysis of the phase 3 TRANSFORM study
Abramson JS; Solomon SR; Arnason J; Johnston PB; Glass B; Bachanova V; Ibrahimi S; Mielke S; Mutsaers P; Hernandez-Ilizaliturri F; Izutsu K; Morschhauser F; Lunning M; Crotta A; Montheard S; Previtali A; Ogasawara K; Kamdar M
Journal article: TRANSPLANTATION AND CELLULAR THERAPY. 2023;29(2):s36-s37
44 Primary Analysis (PA) Results from the Randomized, Phase 3 TRANSFORM Study of Lisocabtagene Maraleucel (liso-cel) Versus Standard of Care (SOC) with Salvage Chemotherapy (CT) Followed By Autologous Stem Cell Transplantation (ASCT) As Second-Line (2L) Treatment in Patients (Pts) with Relapsed or Refractory Large B-Cell Lymphoma (LBCL)
Abramson JS; Solomon SR; Arnason J; Johnston PB; Glass B; Bachanova V; Ibrahimi S; Mielke S; Mutsaers P; Hernandez-Ilizaliturri F; Izutsu K; Morschhauser F; Lunning M; Crotta A; Montheard S; Previtali A; Stepan L; Ogasawara K; Kamdar M
Article: AMERICAN JOURNAL OF HEMATOLOGY. 2023;98(1):112-121
Allogeneic hematopoietic cell transplantation in patients with chronic phase chronic myeloid leukemia in the era of third generation tyrosine kinase inhibitors: A retrospective study by the chronic malignancies working party of the EBMT
Chalandon Y; Sbianchi G; Gras L; Koster L; Apperley J; Byrne J; Salmenniemi U; Sengeloev H; Aljurf M; Helbig G; Kinsella F; Choi G; Remenyi P; Snowden JA; Robin M; Lenhoff S; Mielke S; Passweg J; Broers AEC; Kroeger N; Yegin ZA; Tan SM; Hayden PJ; McLornan DP; Yakoub-Agha I
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1125824
Improved outcomes over time and higher mortality in CMV seropositive allogeneic stem cell transplantation patients with COVID-19; An infectious disease working party study from the European Society for Blood and Marrow Transplantation registry
Ljungman P; Tridello G; Pinana JL; Ciceri F; Sengeloev H; Kulagin A; Mielke S; Yegin ZA; Collin M; Einardottir S; Lepretre SD; Maertens J; Campos A; Metafuni E; Pichler H; Folber F; Solano C; Nicholson E; Yuksel MK; Carlson K; Aguado B; Besley C; Byrne J; Heras I; Dignan F; Kroger N; Robin C; Khan A; Lenhoff S; Grassi A; Dobsinska V; Miranda N; Jimenez M-J; Yonal-Hindilerden I; Wilson K; Averbuch D; Cesaro S; Xhaard A; Knelange N; Styczynski J; Mikulska M; de la Camara R
Article: BONE MARROW TRANSPLANTATION. 2022;57(12):1803-1809
Comparative study of treosulfan plus Fludarabine (FT14) with busulfan plus Fludarabine (FB4) for acute myeloid leukemia in first or second complete remission: An analysis from the European Society for Blood and Marrow Transplantation (EBMT) Acute Leukemia Working Party (ALWP)
Gavriilaki E; Labopin M; Sakellari I; Salmenniemi U; Yakoub-Agha I; Potter V; Berceanu A; Rambaldi A; Hilgendorf I; Kroeger N; Mielke S; Zuckerman T; Sanz J; Busca A; Ozdogu H; Anagnostopoulos A; Savani B; Giebel S; Bazarbachi A; Spyridonidis A; Nagler A; Mohty M
Article: HEMASPHERE. 2022;6(11):e788
CNS Involvement at Initial Diagnosis and Risk of Relapse After Allogeneic HCT for Acute Lymphoblastic Leukemia in First Complete Remission
Kharfan-Dabaja MA; Labopin M; Bazarbachi A; Salmenniemi U; Mielke S; Chevallier P; Rubio MT; Balsat M; Pioltelli P; Menard A-L; Socie G; Huynh A; Schaap N; Rodriguez AB; Cornelissen JJ; Yakoub-Agha I; Aljurf M; Giebel S; Brissot E; Peric Z; Nagler A; Mohty M
Article: EJHAEM. 2022;3(4):1277-1286
Early relapse prediction after allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia (ALL) using lineage-specific chimerism analysis
Lindahl H; Valentini D; Vonlanthen S; Sundin M; Bjorklund AT; Mielke S; Hauzenberger D
Article: BLOOD CANCER JOURNAL. 2022;12(9):140
Comparison of outcomes for HLA-matched sibling and haplo-identical donors in Myelodysplastic syndromes: report from the chronic malignancies working party of EBMT
Raj K; Eikema D-J; Sheth V; Koster L; de Wreede LC; Blaise D; Di Grazia C; Koc Y; Potter V; Chevallier P; Lopez-Corral L; Wu D; Mielke S; Maertens J; Meijer E; Huynh A; Passweg J; Luft T; Perez-Simon JA; Ciceri F; Piekarska A; Hayri Ozsan G; Kroeger N; Robin M; Yakoub-Agha I
Article: IMMUNITY. 2022;55(9):1732-1746.e5
Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccination
Gao Y; Cai C; Wullimann D; Niessl J; Rivera-Ballesteros O; Chen P; Lange J; Cuapio A; Blennow O; Hansson L; Mielke S; Nowak P; Vesterbacka J; Akber M; Perez-Potti A; Sekine T; Muller TR; Boulouis C; Kammann T; Parrot T; Muvva JR; Sobkowiak M; Healy K; Bogdanovic G; Muschiol S; Soderdahl G; Osterborg A; Hellgren F; Grifoni A; Weiskopf D; Sette A; Lore K; Chen MS; Ljungman P; Sandberg JK; Smith CIE; Bergman P; Ljunggren H-G; Aleman S; Buggert M
Journal article: HEMASPHERE. 2022;6:68-69
S167: PREDICTION OF RELAPSE AFTER ALLOGENEIC STEM CELL TRANSPLANTATION USING INDIVIDUALIZED MEASURABLE RESIDUAL DISEASE MARKERS; THE PROSPECTIVE NORDIC STUDY NMDSG14B
Tobiasson M; Pandzic T; Illman J; Nilsson L; Weström S; Sollander K; Ejerblad E; Kittang AO; Olesen G; Werlenius O; Björklund A; Wiggh J; lindholm C; Lorentz F; Rasmussen B; Cammenga J; Weber D; Grönnås D; Dimitriou M; Kytölä S; Walldin G; Ljungman P; Groenbeck K; Mielke S; Jacobsen SE; Ebeling F; Cavelier L; Friis LS; Dybedal I; Hellström‐Lindberg E
Journal article: HEMASPHERE. 2022;6:139-140
S238: MATCHED RELATED VERSUS UNRELATED VERSUS HAPLOIDENTICAL DONORS FOR ALLOGENEIC TRANSPLANTATION IN AML PATIENTS ACHIEVING FIRST COMPLETE REMISSION AFTER TWO INDUCTION COURSES: A STUDY FROM THE ALWP/EBMT
Nagler A; Labopin M; Mielke S; Passweg J; Blaise D; Gedde‐Dahl T; Cornelissen JJ; Salmenniemi U; Yakoub‐Agha I; Reményi P; Socié G; Van Gorkom G; Labussière‐Wallet H; Huang X; Rubio MT; Byrne JL; Craddock C; Griskevicius L; Ciceri F; Mohty M
Article: LANCET. 2022;399(10343):2294-2308
Lisocabtagene maraleucel versus standard of care with salvage chemotherapy followed by autologous stem cell transplantation as second-line treatment in patients with relapsed or refractory large B-cell lymphoma (TRANSFORM): results from an interim analysis of an open-label, randomised, phase 3 trial
Kamdar M; Solomon SR; Arnason J; Johnston PB; Glass B; Bachanova V; Ibrahimi S; Mielke S; Mutsaers P; Hernandez-Ilizaliturri F; Izutsu K; Morschhauser F; Lunning M; Maloney DG; Crotta A; Montheard S; Previtali A; Stepan L; Ogasawara K; Mack T; Abramson JS
Article: MOLECULAR MEDICINE. 2022;28(1):54
MAIT cell compartment characteristics are associated with the immune response magnitude to the BNT162b2 mRNA anti-SARS-CoV-2 vaccine
Boulouis C; Kammann T; Cuapio A; Parrot T; Gao Y; Mouchtaridi E; Wullimann D; Lange J; Chen P; Akber M; Ballesteros OR; Muvva JR; Smith CIE; Vesterbacka J; Kieri O; Nowak P; Bergman P; Buggert M; Ljunggren H-G; Aleman S; Sandberg JK
Article: BONE MARROW TRANSPLANTATION. 2022;57(5):753-759
Lineage-specific early complete donor chimerism and risk of relapse after allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia
Lindahl H; Vonlanthen S; Valentini D; Bjorklund AT; Sundin M; Mielke S; Hauzenberger D
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2022;197(1):82-96
Trends in autologous stem cell transplantation for newly diagnosed multiple myeloma: Changing demographics and outcomes in European Society for Blood and Marrow Transplantation centres from 1995 to 2019
Swan D; Hayden PJ; Eikema D-J; Koster L; Sauer S; Blaise D; Nicholson E; Rabin N; Touzeau C; Byrne J; Huynh A; Cornelissen JJ; Potter V; Forcade E; Parrish C; Gribben J; Chretien M-L; Mielke S; Gedde-Dahl T; Remenyi P; Tsirigotis P; Guinon AG; Beksac M; Schonland S; Yakoub-Agha I
Journal article: TRANSPLANTATION AND CELLULAR THERAPY. 2022;28(3):s56-s57
66 Lisocabtagene Maraleucel (liso-cel), a CD19-Directed Chimeric Antigen Receptor (CAR) T Cell Therapy, Versus Standard of Care (SOC) with Salvage Chemotherapy (CT) Followed By Autologous Stem Cell Transplantation (ASCT) As Second-Line (2L) Therapy in Patients (Pts) with Relapsed or Refractory (R/R) Large B-Cell Lymphoma (LBCL): Results from the Randomized Phase 3 Transform Study
Kamdar M; Solomon SR; Arnason JE; Johnston PB; Glass B; Bachanova V; Ibrahimi S; Mielke S; Mutsaers P; Hernandez-Ilizaliturri FJ; Izutsu K; Morschhauser F; Lunning M; Maloney DG; Crotta A; Montheard S; Previtali A; Stepan L; Ogasawara K; Mack T; Abramson JS
Article: BONE MARROW TRANSPLANTATION. 2022;57(3):423-430
Results of a multicenter phase I/II trial of TCRαβ and CD19-depleted haploidentical hematopoietic stem cell transplantation for adult and pediatric patients
Bethge WA; Eyrich M; Mielke S; Meisel R; Niederwieser D; Schlegel PG; Schulz A; Greil J; Bunjes D; Brecht A; Kuball J; Schumm M; Vucinic V; Wiesneth M; Bonig H; Westinga K; Biedermann S; Holtkamp S; Karitzky S; Malchow M; Siewert C; Handgretinger R; Lang P
Article: ANNALS OF ONCOLOGY. 2022;33(3):259-275
Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA)
Hayden PJ; Roddie C; Bader P; Basak GW; Bonig H; Bonini C; Chabannon C; Ciceri F; Corbacioglu S; Ellard R; Sanchez-Guijo F; Jaeger U; Hildebrandt M; Hudecek M; Kersten MJ; Koehl U; Kuball J; Mielke S; Mohty M; Murray J; Nagler A; Rees J; Rioufol C; Saccardi R; Snowden JA; Styczynski J; Subklewe M; Thieblemont C; Topp M; Ispizua AU; Chen D; Vrhovac R; Gribben JG; Kroeger N; Einsele H; Yakoub-Agha I
Article: MED. 2022;3(2):137-153.e3
Salivary IgG to SARS-CoV-2 indicates seroconversion and correlates to serum neutralization in mRNA-vaccinated immunocompromised individuals
Healy K; Pin E; Chen P; Soderdahl G; Nowak P; Mielke S; Hansson L; Bergman P; Smith CIE; Ljungman P; Valentini D; Blennow O; Osterborg A; Gabarrini G; Al-Manei K; Alkharaan H; Sobkowiak MJ; Yousef J; Mravinacova S; Cuapio A; Xu X; Akber M; Lore K; Hellstrom C; Muschiol S; Bogdanovic G; Buggert M; Ljunggren H-G; Hober S; Nilsson P; Aleman S; Chen MS
Article: MOLECULAR MEDICINE. 2022;28(1):20
NK cell frequencies, function and correlates to vaccine outcome in BNT162b2 mRNA anti-SARS-CoV-2 vaccinated healthy and immunocompromised individuals
Cuapio A; Boulouis C; Filipovic I; Wullimann D; Kammann T; Parrot T; Chen P; Akber M; Gao Y; Hammer Q; Strunz B; Potti AP; Ballesteros OR; Lange J; Muvva JR; Bergman P; Blennow O; Hansson L; Mielke S; Nowak P; Soderdahl G; Osterborg A; Smith CIE; Bogdanovic G; Muschiol S; Hellgren F; Lore K; Sobkowiak MJ; Gabarrini G; Healy K; Chen MS; Alici E; Bjorkstrom NK; Buggert M; Ljungman P; Sandberg JK; Aleman S; Ljunggren H-G
Journal article: HEMASPHERE. 2022;6(11)
CNS Involvement at Initial Diagnosis and Risk of Relapse After Allogeneic HCT for Acute Lymphoblastic Leukemia in First Complete Remission
Kharfan-Dabaja MA; Labopin M; Bazarbachi A; Salmenniemi U; Mielke S; Chevallier P; Therese Rubio M; Balsat M; Pioltelli P; Menard A-L; Socie G; Huynh A; Schaap N; Bermudez Rodriguez A; Cornelissen JJ; Yakoub-Agha I; Aljurf M; Giebel S; Brissot E; Peric Z; Nagler A; Mohty M
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:954716
T cell receptor excision circles are potential predictors of survival in adult allogeneic hematopoietic stem cell transplantation recipients with acute myeloid leukemia
Soderstrom A; Vonlanthen S; Jonsson-Videsater K; Mielke S; Lindahl H; Torlen J; Uhlin M
Article: EBIOMEDICINE. 2021;74:103705
Safety and efficacy of the mRNA BNT162b2 vaccine against SARS-CoV-2 in five groups of immunocompromised patients and healthy controls in a prospective open-label clinical trial
Bergman P; Blennow O; Hansson L; Mielke S; Nowak P; Chen P; Soderdahl G; Osterborg A; Smith CIE; Wullimann D; Vesterbacka J; Lindgren G; Blixt L; Friman G; Wahren-Borgstrom E; Nordlander A; Gomez AC; Akber M; Valentini D; Norlin A-C; Thalme A; Bogdanovic G; Muschiol S; Nilsson P; Hober S; Lore K; Chen MS; Buggert M; Ljunggren H-G; Ljungman P; Aleman S
Journal article: BLOOD. 2021;138(Supplement 1):91
Lisocabtagene Maraleucel (liso-cel), a CD19-Directed Chimeric Antigen Receptor (CAR) T Cell Therapy, Versus Standard of Care (SOC) with Salvage Chemotherapy (CT) Followed By Autologous Stem Cell Transplantation (ASCT) As Second-Line (2L) Treatment in Patients (Pts) with Relapsed or Refractory (R/R) Large B-Cell Lymphoma (LBCL): Results from the Randomized Phase 3 Transform Study
Kamdar M; Solomon SR; Arnason JE; Johnston PB; Glass B; Bachanova V; Ibrahimi S; Mielke S; Mutsaers PGNJ; Hernandez-Ilizaliturri FJ; Izutsu K; Morschhauser F; Lunning MA; Maloney DG; Crotta A; Montheard S; Previtali A; Stepan L; Ogasawara K; Mack T; Abramson JS
Article: LANCET ONCOLOGY. 2021;22(10):1403-1415
Long-term clinical outcomes of tisagenlecleucel in patients with relapsed or refractory aggressive B-cell lymphomas (JULIET): a multicentre, open-label, single-arm, phase 2 study
Schuster SJ; Tam CS; Borchmann P; Worel N; McGuirk JP; Holte H; Waller EK; Jaglowski S; Bishop MR; Damon LE; Foley SR; Westin JR; Fleury I; Ho PJ; Mielke S; Teshima T; Janakiram M; Hsu J-M; Izutsu K; Kersten MJ; Ghosh M; Wagner-Johnston N; Kato K; Corradini P; Martinez-Prieto M; Han X; Tiwari R; Salles G; Maziarz RT
Article: LEUKEMIA. 2021;35(10):2885-2894
COVID-19 and stem cell transplantation; results from an EBMT and GETH multicenter prospective survey
Ljungman P; de la Camara R; Mikulska M; Tridello G; Aguado B; Al Zahrani M; Apperley J; Berceanu A; Bofarull RM; Calbacho M; Ciceri F; Lopez-Corral L; Crippa C; Fox ML; Grassi A; Jimenez M-J; Demir SK; Kwon M; Llamas CV; Lorenzo JLL; Mielke S; Orchard K; Porras RP; Vallisa D; Xhaard A; Knelange NS; Cedillo A; Kroger N; Pinana JL; Styczynski J
Article: JOURNAL OF CLINICAL INVESTIGATION. 2021;131(14):142116
Targeting the αv integrin/TGF-β axis improves natural killer cell function against glioblastoma stem cells
Shaim H; Shanley M; Basar R; Daher M; Gumin J; Zamler DB; Uprety N; Wang F; Huang Y; Gabrusiewicz K; Miao Q; Dou J; Alsuliman A; Kerbauy LN; Acharya S; Mohanty V; Mendt M; Li S; Lu J; Wei J; Fowlkes NW; Gokdemir E; Ensley EL; Kaplan M; Kassab C; Li L; Ozcan G; Banerjee PP; Shen Y; Gilbert AL; Jones CM; Bdiwi M; Nunez-Cortes AK; Liu E; Yu J; Imahashi N; Muniz-Feliciano L; Li Y; Hu J; Draetta G; Marin D; Yu D; Mielke S; Eyrich M; Champlin RE; Chen K; Lang FF; Shpall EJ; Heimberger AB; Rezvani K
Article: BONE MARROW TRANSPLANTATION. 2021;56(5):1171-1179
Use of letermovir in off-label indications: Infectious Diseases Working Party of European Society of Blood and Marrow Transplantation retrospective study
Styczynski J; Tridello G; Xhaard A; Medinger M; Mielke S; Taskinen M; Blijlevens N; Rodriguez MAB; Solano C; Nikolousis E; Biffi A; Groll AH; Junghanss C; Tsirigotis P; Lioure B; Sramek J; Holler E; Galaverna F; Fagioli F; Knelange N; Wendel L; Gil L; de la Camara R; Mikulska M; Ljungman P
Article: BONE MARROW TRANSPLANTATION. 2021;56(3):622-634
Comparable outcomes of haploidentical transplant with TBF conditioning versus matched unrelated donor with fludarabine/busulfan conditioning for acute myeloid leukemia
Bazarbachi A; Labopin M; Blaise D; Forcade E; Socie G; Berceanu A; Angelucci E; Bulabois CE; Kroeger N; Rambaldi A; Ceballos P; Mielke S; El Cheikh J; Yakoub-Agha I; Savani B; Spyridonidis A; Nagler A; Mohty M
Article: ANNALS OF HEMATOLOGY. 2021;100(3):779-787
Abatacept as salvage therapy in chronic graft-versus-host disease-a retrospective analysis
Wertheimer T; Dohse M; Afram G; Weber D; Heidenreich M; Holler B; Kattner A-S; Neubauer A; Mielke S; Ljungman P; Holler E; Herr W; Edinger M; Martinez AP; Fante M; Wolff D
Article: DIAGNOSTICS. 2021;11(2):312
Comparison of Cytomegalovirus-Specific Immune Cell Response to Proteins versus Peptides Using an IFN-γ ELISpot Assay after Hematopoietic Stem Cell Transplantation
Wagner-Drouet E; Teschner D; Wolschke C; Schaefer-Eckart K; Gaertner J; Mielke S; Schreder M; Kobbe G; Hilgendorf I; Klein S; Verbeek M; Ditschkowski M; Koch M; Lindemann M; Schmidt T; Rascle A; Barabas S; Deml L; Wagner R; Wolff D
Article: HAEMATOLOGICA. 2021;106(2):363-374
Standardized monitoring of cytomegalovirus-specific immunity can improve risk stratification of recurrent cytomegalovirus reactivation after hematopoietic stem cell transplantation
Wagner-Drouet E; Teschner D; Wolschke C; Janson D; Schaefer-Eckart K; Gaertner J; Mielke S; Schreder M; Kobbe G; Kondakci M; Hilgendorf I; von Lilienfeld-Toal M; Klein S; Heidenreich D; Kreil S; Verbeek M; Grass S; Ditschkowski M; Gromke T; Koch M; Lindemann M; Huenig T; Schmidt T; Rascle A; Guldan H; Barabas S; Deml L; Wagner R; Wolff D
Article: BONE MARROW TRANSPLANTATION. 2021;56(1):20-29
The outcome of two or more HLA loci mismatched unrelated donor hematopoietic cell transplantation for acute leukemia: an ALWP of the EBMT study
Nagler A; Dholaria B; Labopin M; Bruno B; Rambaldi A; Pioltelli P; La Nasa G; Socie G; Mielke S; Ruggeri M; Saccardi R; Franke G-N; Finke J; Savani BN; Ruggeri A; Mohty M
Journal article: BLOOD. 2020;136(Supplement 1):32-33
COVID-19 and Stem Cell Transplantation; Results from the Prospective Survey By the Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation (EBMT) and the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH)
Ljungman P; De La Camara R; Mikulska M; Tridello G; Aguado B; Beguin Y; Bufarull RM; Ciceri F; Corral LL; Crippa C; Deeren D; Duarte RF; Fox ML; Grassi A; Jimenez M-J; Koculu S; Kwon M; Llamas JCV; Lorenzo JLL; Mielke S; Jiménez JL; Morales ZM; Orchard KH; Porras RP; Potter V; Suárez-Lledó M; Schaap N; Simand C; Sisinni L; Snowden JA; Vallisa D; Yonalhindilerden I; Xhaard A; Knelange NS; Cedillo A; Kröger N; Sanchez JLP; Styczynski J
Journal article: BLOOD. 2020;136:5-6
Prediction of Relapse after Allogeneic Stem Cell Transplantation Using Individualized Minimal Residual Markers; The Prospective Nordic Study NMDSG14B
Tobiasson M; Pandzic T; Illman J; Nilsson L; Westrom S; Olsson D; Ejerblad E; Kittang AO; Olesen G; Werlenius O; Bjorklund AT; Lorentz F; Rasmussen BEH; Cammenga J; Weber D; Dimitriou M; Kytola S; Walldin G; Groenbaek K; Mielke S; Jacobsen SEW; Ebeling F; Cavelier L; Friis LS; Dybedal I; Lindberg EH
Article: BLOOD ADVANCES. 2020;4(14):3357-3367
Large-scale GMP-compliant CRISPR-Cas9-mediated deletion of the glucocorticoid receptor in multivirus-specific T cells
Basar R; Daher M; Uprety N; Gokdemir E; Alsuliman A; Ensley E; Ozcan G; Mendt M; Sanabria MH; Kerbauy LN; Cortes AKN; Li L; Banerjee PP; Muniz-Feliciano L; Acharya S; Fowlkes NW; Lu J; Li S; Mielke S; Kaplan M; Nandivada V; Bdaiwi M; Kontoyiannis AD; Li Y; Liu E; Ang S; Marin D; Brunetti L; Gundry MC; Turk R; Schubert MS; Rettig GR; McNeill MS; Kurgan G; Behlke MA; Champlin R; Shpall EJ; Rezvani K
Article: JOURNAL OF HEMATOLOGY & ONCOLOGY. 2020;13(1):87
Post-transplant cyclophosphamide versus antithymocyte globulin in patients with acute myeloid leukemia in first complete remission undergoing allogeneic stem cell transplantation from 10/10 HLA-matched unrelated donors
Brissot E; Labopin M; Moiseev I; Cornelissen JJ; Meijer E; Van Gorkom G; Rovira M; Ciceri F; Griskevicius L; Blaise D; Forcade E; Mistrik M; Mielke S; Bulabois CE; Niittyvuopio R; Deconinck E; Ruggeri A; Sanz J; Spyridonidis A; Savani B; Giebel S; Nagler A; Mohty M
Article: LEUKEMIA. 2020;34(7):1907-1923
ATIR101 administered after T-cell-depleted haploidentical HSCT reduces NRM and improves overall survival in acute leukemia
Roy DC; Walker I; Maertens J; Lewalle P; Olavarria E; Selleslag D; Lachance S; Buyse M; Wang K; Rovers J; Santi I; Bonig H; Sandler A; Velthuis J; Mielke S
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2020;64(4):e02467-e02419
Phase 2 Study of Anti-Human Cytomegalovirus Monoclonal Antibodies for Prophylaxis in Hematopoietic Cell Transplantation
Maertens J; Logan AC; Jang J; Long G; Tang J-L; Hwang WYK; Koh LP; Chemaly R; Gerbitz A; Winkler J; Yeh S-P; Hiemenz J; Christoph S; Lee D-G; Wang P-N; Holler E; Mielke S; Akard L; Yeo A; Ramachandra S; Smith K; Pertel P; Segal F
Article: BLOOD ADVANCES. 2020;4(4):629-637
Patient-reported long-term quality of life after tisagenlecleucel in relapsed/refractory diffuse large B-cell lymphoma
Maziarz RT; Waller EK; Jaeger U; Fleury I; McGuirk J; Holte H; Jaglowski S; Schuster SJ; Bishop MR; Westin JR; Mielke S; Teshima T; Bachanova V; Foley SR; Borchmann P; Salles GA; Zhang J; Tiwari R; Pacaud LB; Ma Q; Tam CS
Article: TRANSPLANT INFECTIOUS DISEASE. 2020;22(1):e13224
Excretion of Ascaris lumbricoides following reduced-intensity allogeneic hematopoietic stem cell transplantation and consecutive treatment with mebendazole
Luber V; Lutz M; Abele-Horn M; Einsele H; Grigoleit GU; Mielke S
Article: HAEMATOLOGICA. 2020;105(2):297-316
Management of adults and children undergoing chimeric antigen receptor T-cell therapy: best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE)
Yakoub-Agha I; Chabannon C; Bader P; Basak GW; Bonig H; Ciceri F; Corbacioglu S; Duarte RF; Einsele H; Hudecek M; Kersten MJ; Koehl U; Kuball J; Mielke S; Mohty M; Murray J; Nagler A; Robinson S; Saccardi R; Sanchez-Guijo F; Snowden JA; Srour M; Styczynski J; Urbano-Ispizua A; Hayden PJ; Kroeger N
Article: HAEMATOLOGICA. 2020;105(1):47-58
Clinical applications of donor lymphocyte infusion from an HLA-haploidentical donor: consensus recommendations from the Acute Leukemia Working Party of the EBMT
Dholaria B; Savani BN; Labopin M; Luznik L; Ruggeri A; Mielke S; Al Malki MM; Kongtim P; Fuchs E; Huang X-J; Locatelli F; Aversa F; Castagna L; Bacigalupo A; Martelli M; Blaise D; Ben Soussan P; Arnault Y; Handgretinger R; Roy D-C; O'Donnell P; Bashey A; Solomon S; Romee R; Lewalle P; Gayoso J; Maschan M; Lazarus HM; Ballen K; Giebel S; Baron F; Ciceri F; Esteve J; Gorin N-C; Spyridonidis A; Schmid C; Ciurea SO; Nagler A; Mohty M
Article: ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION. 2020;37(3):429-440
Inflammation-Induced Tissue Damage Mimicking GvHD in Human Skin Models as Test Platform for Immunotherapeutics
Wallstabe J; Bussemer L; Groeber-Becker F; Freund L; Alb M; Dragan M; Waaga-Gasser AM; Jakubietz R; Kneitz H; Rosenwald A; Rebhan S; Walles H; Mielke S
Article: LANCET HAEMATOLOGY. 2020;7(1):e28-e39
Treosulfan or busulfan plus fludarabine as conditioning treatment before allogeneic haemopoietic stem cell transplantation for older patients with acute myeloid leukaemia or myelodysplastic syndrome (MC-FludT.14/L): a randomised, non-inferiority, phase 3 trial
Beelen DW; Trenschel R; Stelljes M; Groth C; Masszi T; Remenyi P; Wagner-Drouet E-M; Hauptrock B; Dreger P; Luft T; Bethge W; Vogel W; Ciceri F; Peccatori J; Stoelzel F; Schetelig J; Junghanss C; Grosse-Thie C; Michallet M; Labussiere-Wallet H; Schaefer-Eckart K; Dressler S; Grigoleit GU; Mielke S; Scheid C; Holtick U; Patriarca F; Medeot M; Rambaldi A; Mico MC; Niederwieser D; Franke G-N; Hilgendorf I; Winkelmann NR; Russo D; Socie G; de Latour RP; Holler E; Wolff D; Glass B; Casper J; Wulf G; Menzel H; Basara N; Bieniaszewska M; Stuhler G; Verbeek M; Grass S; Iori AP; Finke J; Benedetti F; Pichlmeier U; Hemmelmann C; Tribanek M; Klein A; Mylius HA; Baumgart J; Dzierzak-Mietla M; Markiewicz M
Article: LEUKEMIA. 2020;34(1):283-292
Haploidentical vs. unrelated allogeneic stem cell transplantation for acute lymphoblastic leukemia in first complete remission: on behalf of the ALWP of the EBMT
Shem-Tov N; Peczynski C; Labopin M; Itala-Remes M; Blaise D; Labussiere-Wallet H; Socie G; Kroeger N; Mielke S; Afanasyev B; Chevallier P; Tischer J; Helbig G; Jindra P; Peric Z; Giebel S; Mohty M; Nagler A
Article: BLOOD ADVANCES. 2019;3(23):4034-4042
The MAGIC algorithm probability is a validated response biomarker of treatment of acute graft-versus-host disease
Srinagesh HK; Ozbek U; Kapoor U; Ayuk F; Aziz M; Ben-David K; Choe HK; DeFilipp Z; Etra A; Grupp SA; Hartwell MJ; Hexner EO; Hogan WJ; Karol AB; Kasikis S; Kitko CL; Kowalyk S; Lin J-Y; Major-Monfried H; Mielke S; Merli P; Morales G; Ordemann R; Pulsipher MA; Qayed M; Reddy P; Reshef R; Roesler W; Sandhu KS; Schechter T; Shah J; Sigel K; Weber D; Woelfl M; Wudhikarn K; Young R; Levine JE; Ferrara JLM
Journal article: BLOOD. 2019;134(Supplement_1):592
Addition of ATIR101, an Adjunctive Treatment Following T-Cell-Depleted Haploidentical HSCT, May Decrease Non-Relapse Mortality and May Improve Survival of Patients with Hematologic Malignancies, Irrespective of Prognostic Risk Factors
Roy DC; Walker I; Maertens JA; Lewalle P; Olavarria E; Beguin Y; Selleslag D; Wagner EM; Bönig H; Bos G; Mielke S
Journal article: BLOOD. 2019;134(Supplement_1):242
Impact of Tisagenlecleucel Chimeric Antigen Receptor (CAR)-T Cell Therapy Product Attributes on Clinical Outcomes in Adults with Relapsed or Refractory Diffuse Large B-Cell Lymphoma (r/r DLBCL)
Bachanova V; Tam CS; Borchmann P; Jaeger U; McGuirk JP; Holte H; Waller EK; Jaglowski S; Bishop MR; Andreadis C; Foley SR; Westin JR; Fleury I; Ho PJ; Mielke S; Teshima T; Salles G; Schuster SJ; Maziarz RT; Van Besien K; Izutsu K; Kersten MJ; Magenau JM; Wagner-Johnston ND; Kato K; Corradini P; Chu J; Gershgorin I; Choquette T; Pacaud LB; Jeschke M
Journal article: BLOOD. 2019;134(Supplement_1):4103
Correlative Analyses of Patient and Clinical Characteristics Associated with Efficacy in Tisagenlecleucel-Treated Relapsed/Refractory Diffuse Large B-Cell Lymphoma Patients in the Juliet Trial
Westin JR; Tam CS; Borchmann P; Jaeger U; McGuirk JP; Holte H; Waller EK; Jaglowski S; Bishop MR; Andreadis C; Foley SR; Fleury I; Ho PJ; Mielke S; Teshima T; Schuster SJ; Bachanova V; Maziarz RT; Van Besien K; Izutsu K; Kersten MJ; Magenau JM; Wagner-Johnston ND; Kato K; Corradini P; Han X; Tiwari R; Agoulnik S; Eldjerou LK; Pacaud LB; Salles GA
Journal article: BLOOD. 2019;134(Supplement_1):2883
Correlation of Bridging and Lymphodepleting Chemotherapy with Clinical Outcomes in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma Treated with Tisagenlecleucel
Andreadis C; Tam CS; Borchmann P; Jaeger U; McGuirk JP; Holte H; Waller EK; Jaglowski S; Bishop MR; Foley SR; Westin JR; Fleury I; Ho PJ; Mielke S; Teshima T; Salles GA; Schuster SJ; Bachanova V; Maziarz RT; Van Besien K; Izutsu K; Magenau JM; Wagner-Johnston ND; Kato K; Corradini P; Tiwari R; Awasthi R; Lawniczek T; Eldjerou LK; Kersten MJ
Journal article: BLOOD. 2019;134:3338
Impact of Donor-Derived CD34+Infused Cell Dose on Outcomes of Patients Undergoing Allo-HCT Following Reduced Intensity Regimen for Myelofibrosis:a Study from the Chronic Malignancies Working Party of the EBMT
Czerw T; Malpassuti V; Iacobelli S; Koster L; Kroeger N; Robin M; Maertens J; Chevallier P; Mielke S; Poire X; Snowden JA; Petersen EJ; Malladi R; Blaise D; Remenyi P; Gandemer V; Cammenga J; Rubio MT; Maury S; Deconinck E; Finnegan D; Hayden P; Boluda JCH; McLornan DP; Yakoub-Agha I
Article: LEUKEMIA. 2019;33(11):2710-2719
Allogeneic transplantation in multiple myeloma: long-term follow-up and cytogenetic subgroup analysis
Knop S; Engelhardt M; Liebisch P; Meisner C; Holler E; Metzner B; Peest D; Kaufmann M; Bunjes D; Straka C; Fischer T; Sezer O; Hentrich M; Ostermann H; Bassermann F; Hess G; Hertenstein B; Freund M; Kropff M; Schmidt CA; Wolf H-H; Jung W; Frickhofen N; Mielke S; Bargou RC; Maschmeyer G; Svaldi M; Langer CH; Gramatzki M; Hebart H; Kanz L; Einsele H; Sezer O; Doerken B; Gerecke C; Fuhrmann S; Ludwig WD; Hertenstein B; Bormann M; Meyer R; Naumann R; Platzbecker U; Roellig C; Roesler W; von Metzler I; Martin H; Engelhardt M; Finke J; Truemper L; Jung W; Schmidt CA; Doelken G; Wolf HH; Mueller L; Ligeti K; Kroeger N; Schilling G; Duerk H; Peest D; Ganser A; Pfreundschuh M; Sayer H; von Lilienfeld-Toal M; Muegge LO; Bentz M; Gramatzki M; Brueggemann M; Fischer T; Wolleschak D; Hess G; Kropff M; Reusch J; Straka C; Ostermann H; Franke D; Peschel C; Dechow T; Bassermann F; Hentrich M; Wandt H; Schaefer-Eckart K; Metzner B; Maschmeyer G; Holler E; Hart C; Reichle A; Freund M; Boettcher S; Kahl C; Mergenthaler HG; Aulitzky W; Kaufmann M; Greiner J; Heidemann E; Kanz L; Hebart H; Liebisch P; Bunjes D; Langer C; Frickhofen N; Einsele H; Knop S; Mielke S; Bargou RC; Svaldi M
Journal article: CLINICAL LYMPHOMA MYELOMA & LEUKEMIA. 2019;19:s251-s252
Correlative Analyses of Cytokine Release Syndrome and Neurological Events in Tisagenlecleucel-Treated Relapsed/Refractory Diffuse Large B-Cell Lymphoma Patients
Bachanova V; Westin J; Tam C; Borchmann P; Jaeger U; McGuirk J; Holte H; Waller E; Jaglowski S; Bishop M; Andreadis C; Foley RS; Fleury I; Teshima T; Mielke S; Salles G; Ho PJ; Izutsu K; Maziarz R; Van Besien K; Kersten MJ; Wagner-Johnston N; Kato K; Corradini P; Han X; Agoulnik S; Chu J; Eldjerou L; Pacaud L; Schuster S
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2019;186(5):754-766
Allodepleted T-cell immunotherapy after haploidentical haematopoietic stem cell transplantation without severe acute graft-versus-host disease (GVHD) in the absence of GVHD prophylaxis
Roy DC; Lachance S; Cohen S; Delisle J-S; Kiss T; Sauvageau G; Busque L; Ahmad I; Bernard L; Bambace N; Boumedine RS; Guertin M-C; Rezvani K; Mielke S; Perreault C; Roy J
Article: ANNALS OF HEMATOLOGY. 2019;98(8):1867-1875
Allogeneic donor split skin grafts for treatment of refractory ulcers in cutaneous chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation-a retrospective analysis on seven patients
Lamby P; Wolff D; Mielke S; Grigoleit GU; Ljungman P; Hilgendorf I; Holler E; Holler B; Weber D; Herr W; Schiltz D; Klein S; Graf S; Bjornhagen-Safwenberg V; Dolderer J; Prantl L
Journal article: HEMASPHERE. 2019;3(S1):338
PF767 PHASE 2 STUDY EVALUATING THE SAFETY AND EFFICACY OF ONE OR TWO DOSES OF DONOR LYMPHOCYTES DEPLETED OF HOST ALLOREACTIVE T‐CELLS (ATIR101) FOLLOWING T‐CELL‐DEPLETED HAPLOIDENTICAL HSCT
Olavarria E; Lewalle P; Beguin Y; Wagner E; Sandler A; Mielke S; Roy D
Journal article: HEMATOLOGICAL ONCOLOGY. 2019;37(S2):505-507
INTRAVENOUS IMMUNOGLOBULIN THERAPY USE IN PATIENTS WITH RELAPSED/REFRACTORY DIFFUSE LARGE B‐CELL LYMPHOMA TREATED WITH TISAGENLECLEUCEL IN THE JULIET TRIAL
Jaeger U; Tam C; Borchmann P; McGuirk J; Holte H; Waller E; Jaglowski S; Andreadis C; Foley SR; Fleury I; Westin J; Teshima T; Mielke S; Salles G; Ho PJ; Izutsu K; Schuster S; Bachanova V; Maziarz R; Van Besien K; Kersten MJ; Wagner‐Johnston N; Kato K; Corradini P; Tiwari R; Forcina A; Pacaud L; Bishop M
Journal article: HEMATOLOGICAL ONCOLOGY. 2019;37(S2):308-310
CORRELATIVE ANALYSES OF CYTOKINE RELEASE SYNDROME AND NEUROLOGICAL EVENTS IN TISAGENLECLEUCEL‐TREATED RELAPSED/REFRACTORY DIFFUSE LARGE B‐CELL LYMPHOMA PATIENTS
Bachanova V; Westin J; Tam C; Borchmann P; Jaeger U; McGuirk J; Holte H; Waller E; Jaglowski S; Bishop M; Andreadis C; Foley SR; Fleury I; Teshima T; Mielke S; Salles G; Ho PJ; Izutsu K; Maziarz R; Van Besien K; Kersten MJ; Wagner‐Johnston N; Kato K; Corradini P; Han X; Agoulnik S; Chu J; Eldjerou L; Pacaud L; Schuster S
Journal article: TRANSPLANTATION AND CELLULAR THERAPY. 2019;25(3):s53-s54
Comparison of Gvhd Biomarker Algorithms for Predicting Lethal Gvhd and Non-Relapse Mortality
Etra A; Gergoudis S; Morales G; Kowalyk S; Lin J-Y; Shah J; Kapoor U; Aziz M; Pawarode A; Ayuk F; Holler E; Choe H; Chen Y-B; Rösler W; Qayed M; Hogan WJ; Wolfl M; Hexner EO; Merli P; Kitko CL; Al Malki MM; Reshef R; Wudhikarn K; Ordemann R; Pulsipher MA; Mielke S; Schechter T; Ozbek U; Ferrara J; Levine JE
Article: NEW ENGLAND JOURNAL OF MEDICINE. 2019;380(1):45-56
Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Schuster SJ; Bishop MR; Tam CS; Waller EK; Borchmann P; McGuirk JP; Jaeger U; Jaglowski S; Andreadis C; Westin JR; Fleury I; Bachanova V; Foley SR; Ho PJP; Mielke S; Magenau JM; Holte H; Pantano S; Pacaud LB; Awasthi R; Chu J; Anak O; Salles G; Maziarz RT
Journal article: BLOOD. 2018;132(Supplement 1):604
Results of a Prospective, Multicenter, Phase I/II Clinical Study in Pediatric and Adult Patients Using TCR Alpha/Beta and CD19 Depleted Haploidentical Hematopoietic Stem Cell Grafts Following Reduced-Intensity Conditioning
Lang P; Handgretinger R; Meisel R; Mielke S; Niederwieser D; Schlegel PG; Greil J; Schulz A; Bader P; Brecht A; Bunjes D; Kuball J; Schumm M; Eyrich MK; Vucinic V; Wiesneth M; Bonig H; Westinga K; Karitzky S; Holtkamp S; Malchow M; Siewert C; Biedermann S; Bethge W
Journal article: OPEN FORUM INFECTIOUS DISEASES. 2018;5(suppl_1):s491-s492
1575. Clinical Validation of a Novel ELISpot-based in vitro Diagnostic Assay to Monitor CMV-Specific Cell-Mediated Immunity in SOT and HSCT Immunocompromised Patients
Banas B; Steubl D; Renders L; Chittka D; Banas M; Wekerle T; Koch M; Witzke O; Lindemann M; Muehlfeld A; Sommerer C; Habicht A; Hugo C; Huenig T; Mielke S; Schreder M; Wagner E; Teschner D; Klein S; Heidenreich D; Kreil S; Schaefer-Eckart K; Gaertner J; Verbeek M; Grass S; Wolschke C; Janson D; Kobbe G; Kondakci M; Ditschkowski M; Gromke T; Hilgendorf I; Von Lilienfeld-Toal M; Schmidt T; Rascle A; Barabas S; Deml L; Wagner R; Kraemer B; Krueger B; Wolff D
Journal article: CYTOTHERAPY. 2018;20(5):s10-s11
10 Phase II study of haploidentical stem cell transplantation using ex vivo photodepletion of donor lymphocyte infusions to eliminate anti-host reactivity results in low relapse rates and high survival rates: Final 2 year follow-up
Roy D; Walker I; Maertens J; Lewalle P; Olavarria E; Selleslag D; Lachance S; Bönig H; Mielke S
Journal article: CLINICAL LYMPHOMA MYELOMA & LEUKEMIA. 2017;17:s373-s374
Global Pivotal Phase 2 Trial of the CD19-Targeted Therapy CTL019 In Adult Patients with Relapsed or Refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL)—An Interim Analysis
Schuster S; Bishop MR; Tam C; Waller EK; Borchmann P; McGuirk J; Jäger U; Jaglowski S; Andreadis C; Westin J; Fleury I; Bachanova V; Foley SR; Ho PJ; Mielke S; Magenau JM; Holte H; Anak O; Pacaud L; Awasthi R; Tai F; Salles G; Maziarz RT
Article: ANNALS OF HEMATOLOGY. 2017;96(9):1463-1470
Imatinib in myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRB in chronic or blast phase
Jawhar M; Naumann N; Schwaab J; Baurmann H; Casper J; Tu-Anh D; Dietze L; Doehner K; Haenel A; Lathan B; Link H; Lotfi S; Maywald O; Mielke S; Mueller L; Platzbecker U; Pruemmer O; Thomssen H; Toepelt K; Panse J; Vieler T; Hofmann W-K; Haferlach T; Haferlach C; Fabarius A; Hochhaus A; Cross NCP; Reiter A; Metzgeroth G
Article: JOURNAL OF HEMATOLOGY & ONCOLOGY. 2017;10(1):130
Comparison of matched sibling donors versus unrelated donors in allogeneic stem cell transplantation for primary refractory acute myeloid leukemia: a study on behalf of the Acute Leukemia Working Party of the EBMT
Brissot E; Labopin M; Stelljes M; Ehninger G; Schwerdtfeger R; Finke J; Kolb H-J; Ganser A; Schaefer-Eckart K; Zander AR; Bunjes D; Mielke S; Bethge WA; Milpied N; Kalhs P; Blau I-W; Kroeger N; Vitek A; Gramatzki M; Holler E; Schmid C; Esteve J; Mohty M; Nagler A
Journal article: HEMATOLOGICAL ONCOLOGY. 2017;35(S2):27
GLOBAL PIVOTAL PHASE 2 TRIAL OF THE CD19‐TARGETED THERAPY CTL019 IN ADULT PATIENTS WITH RELAPSED OR REFRACTORY (R/R) DIFFUSE LARGE B‐CELL LYMPHOMA (DLBCL)—AN INTERIM ANALYSIS
Schuster SJ; Bishop MR; Tam C; Waller EK; Borchmann P; Mcguirk J; Jäger U; Jaglowski S; Andreadis C; Westin J; Fleury I; Bachanova V; Foley SR; Ho PJ; Mielke S; Holte H; Anak O; Pacaud L; Awasthi R; Tai F; Salles G; Maziarz R
Journal article: CYTOTHERAPY. 2017;19(5):e2-e3
LB01 Add back of selectively depleted alloreactive T-cells retaining the full immune repertoire of mature T-cells improves event-free survival (GRFS) and overall survival in a T-cell depleted haploidentical HSCT
Boenig HB; Velthuis J; Walker I; Maertens J; Lewalle P; Olavarria E; Selleslag D; Ruediger M; Hoorn MV; Gerez L; Rovers J; Mielke S; Roy DC
Article: HAEMATOLOGICA. 2017;102(4):e160-e162
Dasatinib and allogeneic stem cell transplantation enable sustained response in an elderly patient with RCSD1-ABL1-positive acute lymphoblastic leukemia
Frech M; Jehn LB; Stabla K; Mielke S; Steffen B; Einsele H; Metzelder SK; Neubauer A
Article: JCI INSIGHT. 2017;2(3):e89798
An early-biomarker algorithm predicts lethal graft-versus-host disease and survival
Hartwell MJ; Ozbek U; Holler E; Renteria AS; Major-Monfried H; Reddy P; Aziz M; Hogan WJ; Ayuk F; Efebera YA; Hexner EO; Bunworasate U; Qayed M; Ordemann R; Wolfl M; Mielke S; Pawarode A; Chen Y-B; Devine S; Harris AC; Jagasia M; Kitko CL; Litzow MR; Kroeger N; Locatelli F; Morales G; Nakamura R; Reshef R; Roesler W; Weber D; Wudhikarn K; Yanik GA; Levine JE; Ferrara JLM
Journal article: BLOOD. 2016;128(22):4512
Boost of Immune Responses Against NY-ESO-1 Following Local Radiation Therapy in Patients with Multiple Myeloma: A Potential Contribution to Tumor Immunosurveillance
Alb M; Tamihardja J; Klinker E; Schreder M; Knop S; Einsele H; Hünig T; Rosenwald A; Flentje M; Mielke S
Journal article: BLOOD. 2016;128(22):1226
Donor Lymphocytes Depleted of Alloreactive T-Cells (ATIR101) Improve Event-Free Survival (GRFS) and Overall Survival in a T-Cell Depleted Haploidentical HSCT: Phase 2 Trial in Patients with AML and ALL
Roy D-C; Lachance S; Roy J; Walker I; Maertens J; Delisle J-S; Foley SR; Lewalle P; Olavarria E; Selleslag D; Rüdiger M; Velthuis J; Gerez L; Rovers J; Bonig H; Mielke S
Article: TRANSPLANTATION AND CELLULAR THERAPY. 2016;22(11):1988-1996
Allogeneic Hematopoietic Cell Transplantation in Multiple Myeloma: Focus on Longitudinal Assessment of Donor Chimerism, Extramedullary Disease, and High-Risk Cytogenetic Features
Rasche L; Roellig C; Stuhler G; Danhof S; Mielke S; Grigoleit GU; Dissen L; Schemmel L; Middeke JM; Ruecker V; Schreder M; Schetelig J; Bornhaeuser M; Einsele H; Thiede C; Knop S
Article: BIOTECHNOLOGY JOURNAL. 2016;11(10):1352-1361
Interactions of donor sources and media influence the histo-morphological quality of full-thickness skin models
Lange J; Weil F; Riegler C; Groeber F; Rebhan S; Kurdyn S; Alb M; Kneitz H; Gelbrich G; Walles H; Mielke S
Article: ONKOLOGE. 2016;22(7):488-492
Suicidal ideation in the clinical context of hematopoietic stem cell transplantation. A systematic review
Hefner J; Mielke S; Csef H
Journal article: CYTOTHERAPY. 2016;18(6):s15
26 Phase II Clinical Trial of Allodepleted T Cell Immunotherapy (ATIR101) Post-Transplant Results in Decreased Transplant-Related Mortality and Improved Survival in Acute Leukemia Patients Undergoing T-Depleted Haploidentical Stem Cell Transplantation
Roy D; Lachance S; Roy J; Walker I; Maertens J; Cohen S; Foley R; Lewalle P; Olavarría E; Selleslag D; Ruediger M; Velthuis J; Reitsma K; Gerez L; Rovers J; Bönig H; Mielke S
Article: TRANSPLANTATION AND CELLULAR THERAPY. 2016;22(1):4-10
International, Multicenter Standardization of Acute Graft-versus-Host Disease Clinical Data Collection: A Report from the Mount Sinai Acute GVHD International Consortium
Harris AC; Young R; Devine S; Hogan WJ; Ayuk F; Bunworasate U; Chanswangphuwana C; Efebera YA; Holler E; Litzow M; Ordemann R; Qayed M; Renteria AS; Reshef R; Woelfl M; Chen Y-B; Goldstein S; Jagasia M; Locatelli F; Mielke S; Porter D; Schechter T; Shekhovtsova Z; Ferrara JLM; Levine JE
Article: ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION. 2016;33(4):415-422
A First Vascularized Skin Equivalent as an Alternative to Animal Experimentation
Groeber F; Engelhardt L; Lange J; Kurdyn S; Schmid FF; Ruecker C; Mielke S; Walles H; Hansmann J
Journal article: BLOOD. 2015;126(23):4396
Allogeneic SCT in Multiple Myeloma: Limited Predictive Value of Chimerism Analysis for Heralding Relapse/Progression Due to Extramedullary Disease
Rasche L; Röllig C; Mielke S; Grigoleit GU; Schreder M; Danhof S; Bornhäuser M; Einsele H; Thiede C; Knop S
Journal article: BLOOD. 2015;126(23):4391
Donor Lymphocytes Depleted of Alloreactive T-Cells (ATIR101) Reduce Transplant Related Mortality and Improve Overall Survival in Haploidentical HSCT for Patients with AML and ALL, Using an Immunosuppressant-Free Transplant Regimen
Roy D-C; Lachance S; Roy J; Walker I; Maertens J; Cohen S; Foley SR; Lewalle P; Olavarria E; Selleslag D; Rudiger M; Velthuis J; Reitsma K; Gerez L; Rovers J; Bonig H; Mielke S
Journal article: BLOOD. 2015;126(23):196
Comparison of Matched-Sibling Donors Versus Unrelated Donors in Allogeneic Stem Cell Transplantation (allo-SCT) for Primary Refractory Acute Myeloid Leukemia (PRF AML): A Report of 1041 Patients from the Acute Leukemia Working Party of the EBMT
Brissot E; Labopin M; Stelljes M; Ehninger G; Stuhler G; Finke J; Kolb HJ; Ganser A; Schaefer-Eckart K; Kroeger N; Bunjes D; Mielke S; Bethge W; Tabrizi R; Peter K; Blau IW; Glass B; Vitek A; Gramatzki M; Holler E; Schmid C; Esteve J; Nagler A; Mohty M
Journal article: BLOOD. 2015;126(23):3154
Guidelines for the Standardization of Acute Graft-Versus-Host Disease Clinical Data Collection: An International Consensus Report
Harris AC; Young R; Devine SM; Hogan WJ; Ayuk F; Bunworasate U; Chanswangphuwana C; Efebera YA; Holler E; Litzow MR; Ordemann R; Qayed M; Renteria AS; Reshef R; Wölfl M; Chen Y-B; Goldstein S; Jagasia MH; Locatelli F; Mielke S; Porter DL; Schechter T; Shekhovtsova Z; Ferrara JLM; Levine JE
Article: LEUKEMIA & LYMPHOMA. 2015;56(12):3365-3369
Control of relapsed or refractory acute myeloid leukemia by clofarabine in preparation for allogeneic stem cell transplant
Loeffler C; Kapp M; Grigoleit G-U; Mielke S; Loeffler J; Heuschmann PU; Malzahn U; Hupp E; Einsele H; Stuhler G
Article: LEUKEMIA. 2015;29(10):2062-2068
Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey
Zeiser R; Burchert A; Lengerke C; Verbeek M; Maas-Bauer K; Metzelder SK; Spoerl S; Ditschkowski M; Ecsedi M; Sockel K; Ayuk F; Ajib S; de Fontbrune FS; Na I-K; Penter L; Holtick U; Wolf D; Schuler E; Meyer E; Apostolova P; Bertz H; Marks R; Luebbert M; Waesch R; Scheid C; Stoelzel F; Ordemann R; Bug G; Kobbe G; Negrin R; Brune M; Spyridonidis A; Schmitt-Graeff A; van der Velden W; Huls G; Mielke S; Grigoleit GU; Kuball J; Flynn R; Ihorst G; Du J; Blazar BR; Arnold R; Kroeger N; Passweg J; Halter J; Socie G; Beelen D; Peschel C; Neubauer A; Finke J; Duyster J; von Bubnoff N
Article: BLOOD. 2015;125(2):261-272
Boost and loss of immune responses against tumor-associated antigens in the course of pregnancy as a model for allogeneic immunotherapy
Lutz M; Worschech A; Alb M; Gahn S; Bernhard L; Schwab M; Obermeier S; Einsele H; Kaemmerer U; Heuschmann P; Klinker E; Otto C; Mielkel S
Journal article: BLOOD. 2014;124(21):314
Selective Photodepletion of Recipient-Alloreactive T-Cells Enables Safe and Efficacious Haploidentical HSCT: Initial Results from a Phase 2 Trial in Patients with AML, ALL, and MDS
Roy D-C; Maertens J; Walker I; Lachance S; Roy J; Foley SR; Lewalle P; Selleslag DLD; De Jong L; Velthuis JHL; Gerez L; Reitsma K; Wagena E; Mielke S
Journal article: BLOOD. 2014;124(21):3831
Men Show Significantly Higher T Lymphocyte Mediated Immune Responses Against H-Y Than Multiparous Women: Results from a Cross-Sectional Analysis in 114 Volunteer Blood Donors and Implications for Immunotherapy
Lutz M; Worschech A; Alb M; Gahn S; Bernhard L; Schwab M; Obermeier S; Einsele H; Kämmerer U; Heuschmann P; Klinker E; Otto C; Mielke S
Article: CLINICAL TRANSPLANTATION. 2014;28(12):1410-1415
Improvement of quality of life in patients with steroid-refractory chronic graft-versushost disease treated with the mTOR inhibitor everolimus
Lutz M; Kapp M; Einsele H; Grigoleit GU; Mielke S
Article: BONE MARROW TRANSPLANTATION. 2014;49(11):1412-1418
Salvage therapy with everolimus reduces the severity of treatment-refractory chronic GVHD without impairing disease control: A dual center retrospective analysis
Mielke S; Lutz M; Schmidhuber J; Kapp M; Ditz D; Ammer J; Einsele H; Grigoleit GU; Holler E; Wolff D
Article: BLOOD. 2014;124(13):2034-2045
Regulatory B cells are enriched within the IgM memory and transitional subsets in healthy donors but are deficient in chronic GVHD
Khoder A; Sarvaria A; Alsuliman A; Chew C; Sekine T; Cooper N; Mielke S; de Lavallade H; Muftuoglu M; Curbelo IF; Liu E; Muraro PA; Alousi A; Stringaris K; Parmar S; Shah N; Shaim H; Yvon E; Molldrem J; Rouce R; Champlin R; McNiece I; Mauri C; Shpall EJ; Rezvani K
Journal article: HAEMATOLOGICA. 2014;99(5):830-835
SRSF2-p95 hotspot mutation is highly associated with advanced forms of mastocytosis and mutations in epigenetic regulator genes.
Hanssens K; Brenet F; Agopian J; Georgin-Lavialle S; Damaj G; Cabaret L; Chandesris MO; de Sepulveda P; Hermine O; Dubreuil P; Soucie E
Article: HAEMATOLOGICA. 2014;99(5):836-847
Leukemia-induced phenotypic and functional defects in natural killer cells predict failure to achieve remission in acute myeloid leukemia
Stringaris K; Sekine T; Khoder A; Alsuliman A; Razzaghi B; Sargeant R; Pavlu J; Brisley G; de Lavallade H; Sarvaria A; Marin D; Mielke S; Apperley JF; Shpall EJ; Barrett AJ; Rezvani K
Journal article: CYTOTHERAPY. 2014;16(4):s27
Immunotherapy with donor lymphocytes depleted of anti-host reactive cells results in safe and efficacious haploidentical HSCT: interim results from a phase II trial in patients with hematologic malignancies
Roy D; Maertens J; Walker I; Foley R; Lewalle P; Selleslag D; Velthuis J; Gerez L; Reitsma K; Wagena E; Roy J; Lachance S; Mielke S
Article: BONE MARROW TRANSPLANTATION. 2014;49(4):581-584
High prevalence of distress in patients after allogeneic hematopoietic SCT: Fear of progression is associated with a younger age
Hefner J; Kapp M; Drebinger K; Dannenmann A; Einsele H; Grigoleit G-U; Faller H; Csef H; Mielke S
Journal article: BLOOD. 2013;122(21):4505
Boost and Loss Of Immune Responses Against Tumor-Associated Antigens In The Course Of Pregnancy As a Model For Immunotherapy
Lutz M; Student M; Alb M; Worschech A; Gahn S; Bernhard L; Schwab M; Einsele H; Kämmerer U; Heuschmann P; Klinker E; Otto C; Mielke S
Article: BONE MARROW TRANSPLANTATION. 2013;48(10):1324-1328
Escalating-dose HLA-mismatched DLI is safe for the treatment of leukaemia relapse following alemtuzumab-based myeloablative allo-SCT
Innes AJ; Beattie R; Sergeant R; Damaj G; Foroni L; Marin D; Kanfer E; Mielke S; Milojkovic D; MacDonald D; Pavlu J; Rahemtulla A; Roberts I; Slade D; Bray E; Goldman J; Apperley J; Szydlo R; Dazzi F; Rezvani K
Article: BLOOD. 2013;122(2):227-238
Tyrosine kinase inhibitors impair B-cell immune responses in CML through off-target inhibition of kinases important for cell signaling
de Lavallade H; Khoder A; Hart M; Sarvaria A; Sekine T; Alsuliman A; Mielke S; Bazeos A; Stringaris K; Ali S; Milojkovic D; Foroni L; Chaidos A; Cooper N; Gabriel I; Apperley J; Belsey S; Flanagan RJ; Goldman J; Shpall EJ; Kelleher P; Marin D; Rezvani K
Journal article: BLOOD. 2012;120(21):4173
Salvage Therapy with Everolimus Reduces the Severity of Treatment-Refractory Chronic Graft-Versus-Host Disease without Impairing Disease Control: A Dual Center Experience
Mielke S; Lutz M; Schmidhuber J; Kapp M; Ammer J; Einsele H; Grigoleit GU; Holler E; Wolff D
Journal article: BLOOD. 2012;120(21):4115
Immune Responses Against the Tumor-Associated Antigens WT1, MUC-1, PRAME and HER2/Neu in 114 Prospectively Screened Healthy Donors: Effects of Gender and Prior Pregnancy and Implications for Immunotherapy
Lutz M; Worschech A; Gahn S; Bernhard L; Schwab M; Einsele H; Kämmerer U; Heuschmann P; Klinker E; Otto C; Mielke S
Article: CANCER IMMUNOLOGY IMMUNOTHERAPY. 2012;61(7):1125-1136
Lymphodepletion is permissive to the development of spontaneous T-cell responses to the self-antigen PR1 early after allogeneic stem cell transplantation and in patients with acute myeloid leukemia undergoing WT1 peptide vaccination following chemotherapy
Rezvani K; Yong ASM; Mielke S; Savani BN; Jafarpour B; Eniafe R; Le RQ; Musse L; Boss C; Childs R; Barrett AJ
Article: TRANSPLANTATION AND CELLULAR THERAPY. 2011;17(12):1855-1861
Selectively T Cell-Depleted Allografts from HLA-Matched Sibling Donors Followed by Low-Dose Posttransplantation Immunosuppression to Improve Transplantation Outcome in Patients with Hematologic Malignancies
Mielke S; McIver ZA; Shenoy A; Fellowes V; Khuu H; Stroncek DF; Leitman SF; Childs R; Battiwalla M; Koklanaris E; Haggerty J; Savani BN; Rezvani K; Barrett AJ
Journal article: BLOOD. 2011;118(21):3020
Reduction in Incidence of Severe Infections by Transplantation of High Doses of Haploidentical T Cells Selectively Depleted of Alloreactive Units
Roy D-C; Guerin M; Boumedine RS; Lachance S; Cohen S; Sauvageau G; Kiss T; Busque L; Morin J; Guertin M-C; Velardi A; Rezvani K; Mielke S; Egeler RM; Barrett AJ; Perreault C; Roy J
Article: HAEMATOLOGICA. 2011;96(3):432-440
Repeated PR1 and WT1 peptide vaccination in Montanide-adjuvant fails to induce sustained high-avidity, epitope-specific CD8⁺ T cells in myeloid malignancies
Rezvani K; Yong ASM; Mielke S; Jafarpour B; Savani BN; Le RQ; Eniafe R; Musse L; Boss C; Kurlander R; Barrett AJ
Journal article: TRANSPLANTATION AND CELLULAR THERAPY. 2011;17(2):s286
Selectively T Cell Depleted Allografts From HLA-Matched Sibling Donors Followed by Low-Dose Post Transplant Immunosuppression to Limit Disease Relapse in Patients With Hematological Malignancies
McIver ZA; Mielke S; Shenoy A; Fellows V; Stroncek D; Leitman S; Childs R; Batiwalla M; Koklanaris EK; Haggerty J; Savani BN; Rezvani K; Barrett AJ
Journal article: BLOOD. 2010;116(21):4705
Selectively T Cell Depleted Allografts From HLA-Matched Sibling Donors Followed by Low-Dose Post Transplant Immunosuppression to Limit Disease Relapse In Patients with Hematological Malignancies
McIver ZA; Mielke S; Shenoy A; Fellows V; Stroncek D; Leitman S; Childs R; Battiwalla M; Koklanaris EK; Haggerty J; Savani BN; Rezvani K; Barrett AJ
Journal article: TRANSPLANTATION AND CELLULAR THERAPY. 2010;16(2):s300
PR1-Specific T Cell Responses In The First Months Following T-Cell Depleted Allogeneic Stem Cell Transplantation Occur In Both Myeloid And Non-Myeloid Malignancies But Are Only Associated With A GVL Effect In Myeloid Leukemias
Rezvani K; Mielke S; Yong A; Savani BN; Jafarpour B; Eniafe R; Barrett AJ
Journal article: BLOOD. 2009;114(22):515
Allografts Selectively Photodepleted of GvHD Causing T Cells and Followed by Low-Level Immunosuppression: A Novel Method to Improve Disease Control After HLA-Matched Sibling Transplantations.
Mielke S; Shenoy A; Rezvani K; Yong ASM; McIver ZA; Fellowes VS; Savani BN; Kurlander R; Khuu H; Boss C; Barrett AJ
Journal article: BLOOD. 2009;114(22):4096
The Response to Repeated Vaccination with PR1 and WT1 Peptides Admixed in Montanide Adjuvant Is Transient and Fails to Induce Sustained Anti-Leukemia Responses in Patients with Myeloid Malignancies.
Rezvani K; Yong ASM; Mielke S; Jafarpour B; Savani BN; Le Q; Eniafe R; Boss C; Kurlander RJ; Barrett AJ
Article: BLOOD. 2009;114(13):2829-2836
Selective depletion of alloreactive T cells by targeted therapy of heat shock protein 90: a novel strategy for control of graft-versus-host disease
Stuehler C; Mielke S; Chatterjee M; Duell J; Lurati S; Rueckert F; Einsele H; Bargou RC; Topp MS
Article: JOURNAL OF CLINICAL MICROBIOLOGY. 2009;47(7):2328-2331
Life-Threatening Infection Caused by Daptomycin-Resistant Corynebacterium jeikeium in a Neutropenic Patient
Schoen C; Unzicker C; Stuhler G; Elias J; Einsele H; Ulrich G; Abele-Horn M; Mielke S
Journal article: JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM. 2009;14(2):69-71
CI-PERINOMS: chemotherapy-induced peripheral neuropathy outcome measures study.
CI-PERINOMS Study Group
Article: BLOOD. 2009;113(10):2245-2255
Ex vivo characterization of polyclonal memory CD8⁺ T-cell responses to PRAME-specific peptides in patients with acute lymphoblastic leukemia and acute and chronic myeloid leukemia
Rezvani K; Yong ASM; Tawab A; Jafarpour B; Eniafe R; Mielke S; Savani BN; Keyvanfar K; Li Y; Kurlander R; Barrett AJ
Journal article: BLOOD. 2008;112(11):2910
Ex-Vivo Characterization of Polyclonal Memory CD8+ T-Cell Responses to PRAME-Specific Peptides in Patients with Acute Leukemia and Chronic Myeloid Leukemia
Rezvani K; Yong ASM; Tawab A; Jafarpour B; Eniafe R; Mielke S; Savani BN; Keyvanfar K; Yixin L; Kurlander R; Barrett AJ
Journal article: BLOOD. 2008;112(11):1168
Selective Allodepletion by TH9402-Mediated Photosensitization Results in Early Full Donor T Cell Reconstitution in the Absence of High-Grade, Acute GvHD and Is Associated with Favorable Outcome after HLA Matched Sibling SCT for Hematologic Malignancies
Mielke S; Shenoy A; Fellowes VS; Rezvani K; Savani BN; Musse L; Wisch L; Kurlander R; Khuu H; Boss C; Barrett AJ
Article: BLOOD. 2008;111(8):4392-4402
A clinical-scale selective allodepletion approach for the treatment of HLA-mismatched and matched donor-recipient pairs using expanded T lymphocytes as antigen-presenting cells and a TH9402-based photodepletion technique
Mielke S; Nunes R; Rezvani K; Fellowes VS; Venne A; Solomon SR; Fan Y; Gostick E; Price DA; Scotto C; Read EJ; Barrett AJ
Article: BLOOD. 2008;111(1):236-242
Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies
Rezvani K; Yong ASM; Mielke S; Savani BN; Musse L; Superata J; Jafarpour B; Boss C; Barrett AJ
Journal article: BLOOD. 2007;110(11):3279
Successful Translation of a GMP-Based, Clinical Scale Selective Allodepletion Approach for Matched Donor-Recipient Pairs from Bench-to-Bedside.
Mielke S; Nunes R; Rezvani K; Fellowes VS; Venne A; Solomon SR; Fan Y; Scotto C; Read EJ; Barrett AJ
Journal article: BLOOD. 2007;110(11):287
Leukemia-Associated Antigen Specific T-Cell Responses Following Combined PR1 and WT1 Peptide Vaccination in Patients with Myeloid Malignancies.
Rezvani K; Yong ASM; Mielke S; Savani BN; Musse L; Superata J; Jafarpour B; Boss C; Barrett AJ
Article: LEUKEMIA. 2007;21(10):2145-2152
Rapid natural killer cell recovery determines outcome after T-cell-depleted HLA-identical stem cell transplantation in patients with myeloid leukemias but not with acute lymphoblastic leukemia
Savani BN; Mielke S; Adams S; Uribe M; Rezvani K; Yong ASM; Zeilah J; Kurlander R; Srinivasan R; Childs R; Hensel N; Barrett AJ
Article: TRANSPLANTATION AND CELLULAR THERAPY. 2007;13(10):1216-1223
Absolute lymphocyte count on day 30 is a surrogate for robust hematopoietic recovery and strongly predicts outcome after T cell-depleted allogeneic stem cell transplantation
Savani BN; Mielke S; Rezvani K; Montero A; Yong AS; Wish L; Superata J; Kurlander R; Singh A; Childs R; Barrett AJ
Article: BLOOD. 2007;110(6):1924-1932
Graft-versus-leukemia effects associated with detectable Wilms tumor-1-specific T lymphocytes after allogeneic stem-cell transplantation for acute lymphoblastic leukemia
Rezvani K; Yong ASM; Savani BN; Mielke S; Keyvanfar K; Gostick E; Price DA; Douek DC; Barrett AJ
Article: BLOOD. 2007;110(5):1603-1606
Deficient CD4⁺ CD25⁺ FOXP3⁺ T regulatory cells in acquired aplastic anemia
Solomou EE; Rezvani K; Mielke S; Malide D; Keyvanfar K; Visconte V; Kajigaya S; Barrett AJ; Young NS
Article: BLOOD. 2007;110(2):770-775
High PR3 or ELA2 expression by CD34⁺ cells in advanced-phase chronic myeloid leukemia is associated with improved outcome following allogeneic stem cell transplantation and may improve PR1 peptide-driven graft-versus-leukemia effects
Yong ASM; Rezvani K; Savani BN; Eniafe R; Mielke S; Goldman JM; Barrett AJ
Journal article: TRANSPLANTATION AND CELLULAR THERAPY. 2007;13(2):121
333: Cytotoxic T lymphocyte responses to PR1 peptide in CML patients inversely correlate with proteinase 3 and elastase expression but donor PR1-responses determine molecular remission and disease eradication after stem cell transplantation
Yong ASM; Rezvani K; Savani BN; Eniafe R; Mielke S; Goldman JM; Barrett J
Journal article: TRANSPLANTATION AND CELLULAR THERAPY. 2007;13(2):117-118
323: Day 30 post-transplant absolute lymphocyte and natural killer cell count strongly predict outcome after allogeneic stem cell transplantation for hematological malignancy
Savani BN; Mielke S; Rezvani K; Yong A; Shenoy A; Read EJ; Hensel N; Childs R; Barrett AJ
Journal article: TRANSPLANTATION AND CELLULAR THERAPY. 2007;13(2):114
314: Selective depletion of alloreacting T cells by TH9402-based photodepletion as a translational strategy for GVHD control in HLA-mismatched and matched donor-recipient pairs
Mielke S; Nunes R; Rezvani K; Fellowes VS; Fan Y; Scotto C; Solomon SP; Read EJ; Barrett AJ
Article: ONKOLOGIE. 2007;30(1-2):49-52
Fatal leukoencephalopathy after reduced-intensity allogeneic stem cell transplantation
Mielke S; Potthoff K; Feuerhake F; Bley TA; Windfuhr M; Bertz H; Finke J
Article: CLINICAL PHARMACOLOGY & THERAPEUTICS. 2007;81(1):76-82
Variants in the SLCO1B3 gene:: Interethnic distribution and association with paclitaxel pharmacokinetics
Smith NF; Marsh S; Scott-Horton TJ; Hamada A; Mielke S; Mross K; Figg WD; Verweij J; McLeod HL; Sparreboom A
Article: TRANSPLANTATION AND CELLULAR THERAPY. 2006;12(12):1318-1325
T cell depleted peripheral blood stem cell allotransplantation with T cell add back for patients with hematological malignancies: Effect of chronic GVHD on outcome
Montero A; Savani BN; Shenoy A; Read EJ; Carter CS; Leitman SF; Mielke S; Rezvani K; Childs R; Barrett AJ
Article: TRANSPLANTATION AND CELLULAR THERAPY. 2006;12(12):1261-1269
Chronic GVHD and pretransplantation abnormalities in pulmonary function are the main determinants predicting worsening pulmonary function in long-term survivors after stem cell transplantation
Savani BN; Montero A; Srinivasan R; Singh A; Shenoy A; Mielke S; Rezvani K; Karimpour S; Childs R; Barrett AJ
Journal article: BLOOD. 2006;108(11):721
High Efficiency Clinical Scale Selective Depletion of Alloreacting T Cells Using Expanded T Lymphocytes as Antigen-Presenting Cells and a TH9402-Based Photodepletion Technique in HLA-Mismatched and Matched Donor-Recipient Pairs.
Mielke S; Nunes R; Rezvani K; Fellowes VS; Fan Y; Solomon SR; Scotto C; Read EJ; Barrett AJ
Journal article: BLOOD. 2006;108(11):5195
PR1-Specific T Cell Responses in the First Months Following T-Cell Depleted Allogeneic Stem Cell Transplantation Occur in Both Myeloid and Non-Myeloid Malignancies but Are Only Associated with a GVL Effect in Myeloid Leukemias.
Rezvani K; Agnes Y; Eniafe RB; Mielke S; Savani BN; Price DA; Gostick E; Douek DC; Goldman JM; Barrett AJ
Journal article: BLOOD. 2006;108(11):3697
Cytotoxic T Lymphocyte Responses to PR1 Peptide in Chronic Myeloid Leukemia Patients Inversely Correlate with Proteinase 3 and Elastase Expression but Donor PR1 Responses Determine Survival after Stem Cell Transplantation.
Yong ASM; Rezvani K; Savani BN; Eniafe R; Mielke S; Goldman JM; Barrett AJ
Journal article: BLOOD. 2006;108(11):3679
WT1-Specific CD8+ T Lymphocytes May Participate in the Elimination of Acute Lymphoblastic Leukemia Following Allogeneic Stem Cell Transplantation.
Rezvani K; Yong A; Mielke S; Savani BN; Price DA; Gostick E; Douek DC; Barrett AJ
Journal article: BLOOD. 2006;108(11):308
Selective Depletion of CD25+ Host-Reactive Donor Lymphocytes from Allografts Preserves a CD25− CD4+foxp3+ Fraction of T Cells and Thereby Provides a Source for Efficient Reconstitution of Regulatory T Cells and Additional GVHD Control.
Mielke S; Rezvani K; Solomon SR; Savani BN; Nunes R; Yong A; Schindler J; Read EJ; Vitetta ES; Barrett AJ
Journal article: BLOOD. 2006;108(11):2993
Total Lymphocyte and Natural Killer (NK) Cell Count Day 30 Post-Transplant Strongly Predict Transplant Outcome after T Cell Depleted Allogeneic Stem Cell Transplantation.
Savani BN; Mielke S; Rezvani K; Yong A; Hensel N; Read EJ; Childs R; Barrett AJ
Journal article: BLOOD. 2006;108(11):2248
FOXP3-Positive Regulatory T-Cells in Acquired Aplastic Anemia.
Solomou EE; Rezvani K; Mielke S; Malide D; Visconte V; Keyvanfar K; Bruno TC; Barrett AJ; Young NS
Article: EUROPEAN JOURNAL OF CANCER. 2006;42(17):2893-2896
Association of ABCB1 genotypes with paclitaxel-mediated peripheral neuropathy and neutropenia
Sissung TM; Mross K; Steinberg SM; Behringer D; Figg WD; Sparreboom A; Mielke S
Article: BLOOD. 2006;108(4):1291-1297
High donor FOXP3-positive regulatory T-cell (T_reg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT
Rezvani K; Mielke S; Ahmadzadeh M; Kilical Y; Savani BN; Zeilah J; Keyvanfar K; Montero A; Hensel N; Kurlander R; Barrett AJ
Article: BLOOD. 2006;107(4):1688-1695
Factors associated with early molecular remission after T cell-depleted allogeneic stem cell transplantation for chronic myelogenous leukemia
Savani BN; Rezvani K; Mielke S; Montero A; Kurlander R; Carter CS; Leitman S; Read EJ; Childs R; Barrett AJ
Journal article: TRANSPLANTATION AND CELLULAR THERAPY. 2006;12(2):103
A novel strategy for selective depletion of host-reactive donor lymphocytes by photodepletion is efficient at clinical scale conditions and preserves foxp3+ regulatory T cells
Mielke S; Rezvani K; Fellowes V; Venne A; Solomon SR; Fan Y; Hensel N; Carter CS; Read EJ; Barrett AJ
Article: CLINICAL CANCER RESEARCH. 2005;11(24):8799-8807
T-cell responses directed against multiple HLA-A*0201-restricted epitopes derived from Wilms' tumor 1 protein in patients with leukemia and healthy donors: Identification, quantification, and characterization
Rezvani K; Brenchley JM; Price DA; Kilical Y; Gostick E; Sewell AK; Li JM; Mielke S; Douek DC; Barrett AJ
Journal article: BLOOD. 2005;106(11):595
Reconstitution of Regulatory T Cells after Selective Depletion of CD25+ Host-Reactive Donor Lymphocytes from Allografts and Association with Acute Graft-Versus-Host-Disease.
Mielke S; Rezvani K; Solomon SR; Kilical Y; Savani BN; Wish L; Carter CS; Schindler J; Hensel N; Kurlander R; Read EJ; Vitetta ES; Barrett AJ
Journal article: BLOOD. 2005;106(11):2764
Identification of Novel MHC Class I and Class II Epitopes of WT1 Using a Peptide Library Screen.
Rezvani K; Mielke S; Kilical Y; Grube M; Fujiwara H; Sconocchia G; Lee J; El-Ouriaghi F; Hensel N; Barrett AJ
Journal article: BLOOD. 2005;106(11):2384
Robust Expansion of Cytomegalovirus (CMV) Antigen-Specific CD4+ and CD8+ T Cells Using Gene-Modified Activated T Cells as Antigen Presenting Cells.
Melenhorst JJ; Solomon SR; Mielke S; Hensel NF; Barrett AJ
Journal article: BLOOD. 2005;106(11):1416
Inverse Correlation of Early Regulatory T Cell Reconstitution Post-Transplant and Acute and Chronic Graft-Versus-Host-Disease.
Rezvani K; Mielke S; Kilical Y; Savani B; Keyvanfar K; Hensel N; Kurlander R; Barrett AJ
Journal article: BLOOD. 2005;106(11):140
T-Cell Depleted PBSCT Mitigates Acute GVHD, but Preserves Protective Chronic GVHD. Long Term Follow up of 138 Patients.
Montero A; Savani BN; Mielke S; Solomon SR; Childs R; Barrett AJ
Journal article: BLOOD. 2005;106(11):1405
Transplant Outcome in Acute Myeloid but Not Acute Lymphocytic Leukemia Following T Cell Depleted Allogeneic Stem Cell Transplantation May Be Favorably Influenced by Early Recovery of NK Cells.
Savani BN; Montero A; Mielke S; Rezvani K; Shenoy A; Childs R; Barrett AJ
Article: CLINICAL CANCER RESEARCH. 2005;11(22):8097-8104
Association of CYP2C8, CYP3A4, CYP3A5, and ABCB1 polymorphisms with the pharmacokinetics of paclitaxel
Henningsson A; Marsh S; Loos WJ; Karlsson MO; Garsa A; Mross K; Mielke S; Viganò L; Locatelli A; Verweij J; Sparreboom A; McLeod HL
Article: ANTICANCER RESEARCH. 2005;25(6C):4423-4427
Paclitaxel pharmacokinetics and response to chemotherapy in patients with advanced cancer treated with a weekly regimen
Mielke S; Sparreboom A; Behringer D; Mross K
Article: BLOOD. 2005;106(3):1123-1129
Selective depletion of alloreactive donor lymphocytes: a novel method to reduce the severity of graft-versus-host disease in older patients undergoing matched sibling donor stem cell transplantation
Solomon SR; Mielke S; Savani BN; Montero A; Wisch L; Childs R; Hensel N; Schindler J; Ghetie V; Leitman SF; Mai T; Carter CS; Kurlander R; Read EJ; Vitetta ES; Barrett AJ
Article: CLINICAL CANCER RESEARCH. 2005;11(13):4843-4850
Association of paclitaxel pharmacokinetics with the development of peripheral neuropathy in patients with advanced cancer
Mielke S; Sparreboom A; Steinberg SM; Gelderblom H; Unger C; Behringer D; Mross K
Article: CYTOTHERAPY. 2005;7(2):109-115
Selective depletion strategies in allogeneic stem cell transplantation
Mielke S; Solomon SR; Barrett AJ
Journal article: BLOOD. 2004;104(11):426
Selective Depletion of Alloreacting CD25+ Cells from Stem Cell Allografts Can Reduce Acute Graft-Versus-Host Disease Following Matched Related Donor Transplantation.
Solomon SR; Tran T; Carter CS; Hensel N; Wisch L; Mielke S; Read E; Ghetie V; Schindler J; Vitetta E; Barrett J
Article: GEBURTSHILFE UND FRAUENHEILKUNDE. 2004;64(11):1199-1204
Practical aspects in the treatment of metastatic breast cancer with administration of paclitaxel weekly
Jackisch C; Grothey A; Schlotter CM; Mielke S; Wassmann KI; Behringer D; Mross K; Rody A
Article: ANTI-CANCER DRUGS. 2003;14(10):785-792
Comparative neurotoxicity of weekly non-break paclitaxel infusions over 1 versus 3 h.
Mielke S; Mross K; Gerds TA; Schmidt A; Wäsch R; Berger DP; Lange W; Behringer D
Journal article: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2003;1(5):s164
542 A multicenter, randomized phase III study on neurotoxicity, safety and efficacy of weekly Pacilitaxel infused over 1-h vs. 3-h in patients with advanced solid tumors
Mielke S; Mross K; Gerds TA; Schmidt A; Lange W; Behringer D
Article: IN VIVO. 2003;17(5):505-507
Fatal outcome in a patient with metastatic prostate cancer and acquired severe hypogammaglobulinemia with complete absence of mature peripheral blood B-cells
Lohr J; Mielke S; Lübbert M; Behringer D
Article: ONKOLOGIE. 2002;25(6):503-508
Comparison of 1-hour and 3-hours paclitaxel infusion pharmacokinetics:: Results from a randomized trial
Mross K; Häring B; Holländer N; Mielke S; Behringer D; Massing U; Unger C
Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2002;20(2):574-581
Comparative Pharmacokinetics of Unbound Paclitaxel During 1- and 3-Hour Infusions
Gelderblom H
Article: JOURNAL OF CLINICAL ONCOLOGY. 2002;20(2):574-581
Comparative pharmacokineties of unbound paclitaxel during 1-and 3-hour infusions
Gelderblom H; Mross K; ten Tije AJ; Behringer D; Mielke S; van Zomeren DM; Verweij J; Sparreboom A
Article: HANDCHIRURGIE MIKROCHIRURGIE PLASTISCHE CHIRURGIE. 1999;31(4):241-245
[Results of therapy after primary conservative management of distal radius fractures in patients over 65 years of age].
Jakob M; Mielke S; Keller H; Metzger U
Article: MEDICAL HYPOTHESES. 1998;50(5):359-362
Expression of the c-erbB-2-encoded oncoprotein p185 (HER-2/neu) in pregnancy as a model for oncogene-induced carcinogenesis
Mielke S; Meden H; Kuhn W
Article: GYNECOLOGICAL ENDOCRINOLOGY. 1997;11(4):237-241
In vivo effects of estrogens on c-erbB-2 oncoprotein levels in chorionic villous tissue and maternal serum
Mielke S; Meden H; Marx D; Wuttke W; Kuhn W
Article: ANTICANCER RESEARCH. 1997;17(4B):3125-3127
Effects of interfering and influencing factors on the analyses of p105 (c-erbB-2/HER-2) oncoprotein fragment in serum
Mielke S; Meden H; Raab T; Wuttke W; Kuhn W
Article: ANTICANCER RESEARCH. 1997;17(4B):3075-3077
Hormonal treatment with sex steroids in women is associated with lower p105 serum concentrations
Meden H; Mielke S; Marx D; Wuttke W; Kuhn W
Article: JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH. 1997;23(2):213-217
Elevated serum levels of the c-erbB-2 encoded oncoprotein fragment in cases of pure preeclampsia and HELLP syndrome.
Meden H; Mielke S; Wuttke W; Kuhn W
Article: IN VIVO. 1997;11(1):51-54
Serum levels of the c-erbB-2 (HER2/neu) encoded oncoprotein fragment p105 in normal pregnancies
Meden H; Mielke S; Schauer A; Kuhn W
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