Stephan Mielke
About me
Stephan Mielke started as Professor of Hematology and Cell Therapy at Karolinska Institutet and Department Head and Scientific Director at the Cancer Center of Karolinska University Hospital in May 2017. He graduated in 1999 from Medical School and received his doctoral degree from Georg-August University in Göttingen. Trained in Internal Medicine, Hematology and Oncology at the University of Freiburg he was awarded a postdoctoral fellowship at the National Institutes of Health (NIH) in Bethesda, Maryland, where he initaited clinical trials as a principle investigator and has since devoted his career to the development of advanced therapy medicinal products (ATMP) in cancer care. In 2007 he returned to Germany and became Director of the newly built Adult Allogeneic Stem Cell Transplantation Program and in 2014 Professor of Internal Medicine at the University of Würzburg. He focused on graft manipulation in haplo-identical stem cell transplantation and initiated world-wide multicenter trials with ATMPs as coordinating investigator.
Mielke is one of Europe's pioneers in CAR T-cell therapy, being one of the first in Germany treating patients with CAR T-cells in 2016 as part of the JULIET trial (NEJM 2019) and was the first to perform CAR T cell therapy in 2019 at Karolinska as part of the TRANSFORM trial (Lancet 2022). He has performed Sweden's first standard of care CAR T cell treatment in 2019 and has recruited several international trials to Karolinska such as the TRANSCEND FOL study (Nature Med 2024). In close cooperation with the Phase I Unit the first solid tumor patients in the Nordics received gene-modified effector cells (TCR and CAR-T cells). Stephan Mielke has taken a leading role in the foundation of Karolinska Comprehensive Cancer Center (2020) as well as Karolinska ATMP Center, a cell and genetherapy center (2024). In 2019 he founded SWECARNET, Sweden’s CAR T cell network, a co-creational cooperation between academia, healthcare and industry to foster access to CAR T cell therapy for all patients in Sweden, serving today as an European role-model.
Actual Positions:
Professor of Hematology and Cellular Therapy (LabMed, MedH)
Head of Department and Senior Physician at the Center of Allogeneic Stem Cell Transplantation and Cellular Therapy (ME CAST, Tema Cancer).
Director of the Cellular Therapy and Allogeneic Stem Cell Transplantation Program (JACIE).
Member of Board of Directors of Karolinska Comprehensive Cancer Center (OECI) and Karolinska ATMP Center
Research
Stephan Mielke, Professor of Hematology and Cell Therapy at Karolinska Institutet and Head of Department at Karolinska University Hospital in Stockholm, is a translational physician-scientist with Swedish board certification in Internal Medicine and Hematology and a special interest in cell- and gene therapy. His research group is closely related to both the reseach laboratory as well as the Department of Cellular Therapy and Allogeneic Stem Cell Transplantation and focuses on efficient translation of innovation from bench-to-bedside as well as from bedside-to-bench: "We work translational and co-creational with the patient in the center to provide fast access to innovation" explains Stephan Mielke. A central aim of this research is to increase the rates of cure for patients with leukemia and MDS, lymphoma, myeloma and solid tumors by harnessing the benefits of autologous and allogeneic immunity and maintain quality of life. More recently the treatment of inborn errors, immune defects and autoimmune diseases with both transplantation as well as cell and gene therapy have gained more and more attention. Stephan Mielke has built a wide-spread national and international network, has received several grants, has pulished more than 130 papers and is regularly invited as a peer scientific reviewer for several international journals and funding organizations in the field of stem cell transplantation, cell and gene therapy as well as personalized medicine. He is regulary called in as international export and part of several European initiatives in the ATMP field such as JOIN4ATMP and the GoCART coalition.
Teaching
Stephan Mielke, Professor of Hematology and Cell Therapy and Department Head of Cellular Therapy and Allogeneic Stem Cell Transplantation (CAST) at Karolinska Institutet and University Hospital in Stockholm, is an expierenced academic and clinical teacher who has started his teaching carrier already as a student at the University of Göttingen in 1992 and has devoted since extensive efforts into teaching, training and mentoring of medical students and other health-care and biomedical professionals for more than three decades. He likes interdiciplinary, interprofessional and cross-curricular teaching approaches to provide different perspectives to students and generate better system understanding. His teaching style is interactive and motivating, inviting everybody to participate and to challenge where needed. As an internationally recognized expert for the fields of cell- and gene therapy, personalized medicine and comprehensive cancer therapy he has delivered several invited educational lectures at international meetings over the years. He has been supervising several master students and doctaral candidates (Dr. med./PhD)
Articles
- Article: BONE MARROW TRANSPLANTATION. 2024;59(10):1402-1412
- Article: LEUKEMIA. 2024;38(9):1985-1991
- Article: AMERICAN JOURNAL OF HEMATOLOGY. 2024;99(9):1732-1745
- Article: CANCER. 2024;130(15):2642-2651
- Article: NATURE MEDICINE. 2024;30(8):2199-2207
- Article: TRANSPLANTATION AND CELLULAR THERAPY. 2024;:S2666-6367(24)00547-5
- Article: BLOOD. 2024;144(3):323-333
- Article: BONE MARROW TRANSPLANTATION. 2024;59(7):1012-1021
- Article: LEUKEMIA. 2024;38(5):1156-1163
- Article: JOURNAL OF CLINICAL ONCOLOGY. 2024;42(12):1378-1390
- Article: CELL HOST AND MICROBE. 2024;32(2):156-161.e3
- Journal article: TRANSPLANTATION AND CELLULAR THERAPY. 2024;30(2):s258-s259
- Journal article: TRANSPLANTATION AND CELLULAR THERAPY. 2024;30(2):s46-s47
- Article: TRANSPLANTATION AND CELLULAR THERAPY. 2024;30(1):95.e1-95.e10
- Journal article: OPEN FORUM INFECTIOUS DISEASES. 2023;10(Supplement_2):ofad500.555
- Journal article: BLOOD. 2023;142:237
- Journal article: BLOOD. 2023;142:3592
- Journal article: BLOOD. 2023;142:1047
- Article: BLOOD. 2023;142(10):865-877
- Article: SCIENCE ADVANCES. 2023;9(30):eadd6997
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2023;15(704):eadg9452
- Article: BONE MARROW TRANSPLANTATION. 2023;58(7):791-800
- Journal article: HEMATOLOGICAL ONCOLOGY. 2023;41(S2):877-880
- Article: BONE MARROW TRANSPLANTATION. 2023;58(6):710-716
- Journal article: JOURNAL OF IMMUNOLOGY. 2023;210(1_Supplement):75.16
- Article: BLOOD. 2023;141(14):1675-1684
- Journal article: TRANSPLANTATION AND CELLULAR THERAPY. 2023;29(2):s36-s37
- Article: AMERICAN JOURNAL OF HEMATOLOGY. 2023;98(1):112-121
- Article: BONE MARROW TRANSPLANTATION. 2022;57(12):1803-1809
- Article: HEMASPHERE. 2022;6(11):e788
- Article: BLOOD CANCER JOURNAL. 2022;12(9):140
- Article: IMMUNITY. 2022;55(9):1732-1746.e5
- Journal article: HEMASPHERE. 2022;6:68-69
- Article: THE LANCET. 2022;399(10343):2294-2308
- Article: MOLECULAR MEDICINE. 2022;28(1):54
- Article: BONE MARROW TRANSPLANTATION. 2022;57(5):753-759
- Article: BRITISH JOURNAL OF HAEMATOLOGY. 2022;197(1):82-96
- Journal article: TRANSPLANTATION AND CELLULAR THERAPY. 2022;28(3):s56-s57
- Article: BONE MARROW TRANSPLANTATION. 2022;57(3):423-430
- Article: ANNALS OF ONCOLOGY. 2022;33(3):259-275
- Article: MED. 2022;3(2):137-153.e3
- Article: MOLECULAR MEDICINE. 2022;28(1):20
- Journal article: HEMASPHERE. 2022;6(11)
- Article: FRONTIERS IN IMMUNOLOGY. 2022;13:954716
- Journal article: BLOOD. 2021;138(Supplement 1):91
- Article: LEUKEMIA. 2021;35(10):2885-2894
- Article: THE LANCET ONCOLOGY. 2021;22(10):1403-1415
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2021;131(14):142116
- Article: BONE MARROW TRANSPLANTATION. 2021;56(5):1171-1179
- Article: BONE MARROW TRANSPLANTATION. 2021;56(3):622-634
- Article: ANNALS OF HEMATOLOGY. 2021;100(3):779-787
- Article: BONE MARROW TRANSPLANTATION. 2021;56(1):20-29
- Journal article: BLOOD. 2020;136(Supplement 1):32-33
- Article: BLOOD ADVANCES. 2020;4(14):3357-3367
- Article: JOURNAL OF HEMATOLOGY AND ONCOLOGY. 2020;13(1):87
- Article: LEUKEMIA. 2020;34(7):1907-1923
- Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2020;64(4):e02467-e02419
- Article: BLOOD ADVANCES. 2020;4(4):629-637
- Article: TRANSPLANT INFECTIOUS DISEASE. 2020;22(1):e13224
- Article: HAEMATOLOGICA. 2020;105(1):47-58
- Article: ALTEX. 2020;37(3):429-440
- Article: THE LANCET HAEMATOLOGY. 2020;7(1):e28-e39
- Article: BLOOD ADVANCES. 2019;3(23):4034-4042
- Journal article: BLOOD. 2019;134(Supplement_1):242
- Journal article: BLOOD. 2019;134(Supplement_1):4103
- Journal article: BLOOD. 2019;134(Supplement_1):2883
- Article: LEUKEMIA. 2019;33(11):2710-2719
- Article: BRITISH JOURNAL OF HAEMATOLOGY. 2019;186(5):754-766
- Journal article: CLINICAL LYMPHOMA, MYELOMA AND LEUKEMIA. 2019;19:s251-s252
- Journal article: HEMATOLOGICAL ONCOLOGY. 2019;37(S2):505-507
- Journal article: HEMATOLOGICAL ONCOLOGY. 2019;37(S2):308-310
- Journal article: TRANSPLANTATION AND CELLULAR THERAPY. 2019;25(3):s53-s54
- Article: NEW ENGLAND JOURNAL OF MEDICINE. 2019;380(1):45-56
- Journal article: OPEN FORUM INFECTIOUS DISEASES. 2018;5(suppl_1):s491-s492
- Article: ANNALS OF HEMATOLOGY. 2017;96(9):1463-1470
- Journal article: CLINICAL LYMPHOMA, MYELOMA AND LEUKEMIA. 2017;17:s373-s374
- Article: JOURNAL OF HEMATOLOGY AND ONCOLOGY. 2017;10(1):130
- Journal article: HEMATOLOGICAL ONCOLOGY. 2017;35(S2):27
- Article: HAEMATOLOGICA. 2017;102(4):e160-e162
- Article: JCI INSIGHT. 2017;2(3):e89798
- Journal article: BLOOD. 2016;128(22):4512
- Article: TRANSPLANTATION AND CELLULAR THERAPY. 2016;22(11):1988-1996
- Article: BIOTECHNOLOGY JOURNAL. 2016;11(10):1352-1361
- Article: ONKOLOGE. 2016;22(7):488-492
- Article: TRANSPLANTATION AND CELLULAR THERAPY. 2016;22(1):4-10
- Article: ALTEX. 2016;33(4):415-422
- Journal article: BLOOD. 2015;126(23):4396
- Journal article: BLOOD. 2015;126(23):3154
- Article: LEUKEMIA AND LYMPHOMA. 2015;56(12):3365-3369
- Article: LEUKEMIA. 2015;29(10):2062-2068
- Article: BLOOD. 2015;125(2):261-272
- Article: CLINICAL TRANSPLANTATION. 2014;28(12):1410-1415
- Article: BONE MARROW TRANSPLANTATION. 2014;49(11):1412-1418
- Article: BLOOD. 2014;124(13):2034-2045
- Journal article: HAEMATOLOGICA. 2014;99(5):830-835
- Article: HAEMATOLOGICA. 2014;99(5):836-847
- Article: BONE MARROW TRANSPLANTATION. 2014;49(4):581-584
- Journal article: BLOOD. 2013;122(21):4505
- Article: BONE MARROW TRANSPLANTATION. 2013;48(10):1324-1328
- Article: BLOOD. 2013;122(2):227-238
- Article: CANCER IMMUNOLOGY, IMMUNOTHERAPY. 2012;61(7):1125-1136
- Article: TRANSPLANTATION AND CELLULAR THERAPY. 2011;17(12):1855-1861
- Journal article: BLOOD. 2011;118(21):3020
- Article: HAEMATOLOGICA. 2011;96(3):432-440
- Journal article: TRANSPLANTATION AND CELLULAR THERAPY. 2011;17(2):s286
- Journal article: TRANSPLANTATION AND CELLULAR THERAPY. 2010;16(2):s300
- Article: BLOOD. 2009;114(13):2829-2836
- Article: JOURNAL OF CLINICAL MICROBIOLOGY. 2009;47(7):2328-2331
- Journal article: JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM. 2009;14(2):69-71
- Journal article: BLOOD. 2008;112(11):2910
- Article: BLOOD. 2008;111(1):236-242
- Journal article: BLOOD. 2007;110(11):3279
- Journal article: BLOOD. 2007;110(11):287
- Article: TRANSPLANTATION AND CELLULAR THERAPY. 2007;13(10):1216-1223
- Article: BLOOD. 2007;110(5):1603-1606
- Journal article: TRANSPLANTATION AND CELLULAR THERAPY. 2007;13(2):121
- Journal article: TRANSPLANTATION AND CELLULAR THERAPY. 2007;13(2):117-118
- Journal article: TRANSPLANTATION AND CELLULAR THERAPY. 2007;13(2):114
- Article: ONKOLOGIE. 2007;30(1-2):49-52
- Article: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2007;81(1):76-82
- Article: TRANSPLANTATION AND CELLULAR THERAPY. 2006;12(12):1318-1325
- Article: TRANSPLANTATION AND CELLULAR THERAPY. 2006;12(12):1261-1269
- Journal article: BLOOD. 2006;108(11):3679
- Journal article: BLOOD. 2006;108(11):2248
- Article: EUROPEAN JOURNAL OF CANCER. 2006;42(17):2893-2896
- Article: BLOOD. 2006;108(4):1291-1297
- Article: BLOOD. 2006;107(4):1688-1695
- Journal article: TRANSPLANTATION AND CELLULAR THERAPY. 2006;12(2):103
- Article: CLINICAL CANCER RESEARCH. 2005;11(24):8799-8807
- Journal article: BLOOD. 2005;106(11):2764
- Journal article: BLOOD. 2005;106(11):2384
- Journal article: BLOOD. 2005;106(11):1416
- Journal article: BLOOD. 2005;106(11):140
- Article: CLINICAL CANCER RESEARCH. 2005;11(22):8097-8104
- Article: ANTICANCER RESEARCH. 2005;25(6C):4423-4427
- Article: CLINICAL CANCER RESEARCH. 2005;11(13):4843-4850
- Article: CYTOTHERAPY. 2005;7(2):109-115
- Article: GEBURTSHILFE UND FRAUENHEILKUNDE. 2004;64(11):1199-1204
- Article: ANTI-CANCER DRUGS. 2003;14(10):785-792
- Journal article: EJC SUPPLEMENTS. 2003;1(5):s164
- Article: ONKOLOGIE. 2002;25(6):503-508
- Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2002;20(2):574-581
- Article: JOURNAL OF CLINICAL ONCOLOGY. 2002;20(2):574-581
- Article: HANDCHIRURGIE MIKROCHIRURGIE PLASTISCHE CHIRURGIE. 1999;31(4):241-245
- Article: MEDICAL HYPOTHESES. 1998;50(5):359-362
- Article: GYNECOLOGICAL ENDOCRINOLOGY. 1997;11(4):237-241
- Article: ANTICANCER RESEARCH. 1997;17(4B):3125-3127
- Article: ANTICANCER RESEARCH. 1997;17(4B):3075-3077
- Article: JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH. 1997;23(2):213-217
- Article: IN VIVO. 1997;11(1):51-54
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All other publications
- Letter: BONE MARROW TRANSPLANTATION. 2024;59(11):1631-1634
- Corrigendum: NATURE MEDICINE. 2024;30(8):2374
- Review: FUTURE ONCOLOGY. 2024;20(21):1455-1465
- Conference publication: LEUKEMIA RESEARCH. 2023;128:107227
- Conference publication: BRITISH JOURNAL OF HAEMATOLOGY. 2023;201:10-11
- Conference publication: BONE MARROW TRANSPLANTATION. 2023;58(SUPP1):281-282
- Conference publication: BONE MARROW TRANSPLANTATION. 2023;58(SUPP1):85-86
- Conference publication: BONE MARROW TRANSPLANTATION. 2023;58(SUPP1):66-67
- Conference publication: BONE MARROW TRANSPLANTATION. 2023;58(SUPP1):58-59
- Conference publication: BONE MARROW TRANSPLANTATION. 2023;58(SUPP1):466-467
- Conference publication: BONE MARROW TRANSPLANTATION. 2023;58(SUPP1):143-144
- Conference publication: ONCOLOGY RESEARCH AND TREATMENT. 2023;46:272-273
- Conference publication: ONCOLOGY RESEARCH AND TREATMENT. 2023;46:75
- Conference publication: JOURNAL OF IMMUNOLOGY. 2023;210(1)
- Conference publication: CLINICAL LYMPHOMA, MYELOMA AND LEUKEMIA. 2023;23:S447-S448
- Conference publication: BLOOD. 2022;140:1581-1583
- Conference publication: BLOOD. 2022;140:900-902
- Letter: BLOOD ADVANCES. 2022;6(16):4816-4820
- Preprint: RESEARCH SQUARE. 2022
- Letter: LEUKEMIA AND LYMPHOMA. 2022;63(3):755-758
- Conference publication: ONCOLOGY RESEARCH AND TREATMENT. 2022;45(SUPPL 3):55
- Conference publication: ONCOLOGY RESEARCH AND TREATMENT. 2022;45(SUPPL 3):165-166
- Conference publication: ONCOLOGY RESEARCH AND TREATMENT. 2022;45(SUPPL 3):179
- Conference publication: BONE MARROW TRANSPLANTATION. 2022;57(SUPPL 1):163-164
- Conference publication: BONE MARROW TRANSPLANTATION. 2022;57(SUPPL 1):188-189
- Conference publication: BONE MARROW TRANSPLANTATION. 2022;57(SUPPL 1):19-20
- Conference publication: ONCOLOGY RESEARCH AND TREATMENT. 2022;45(SUPPL 2):194
- Conference publication: BONE MARROW TRANSPLANTATION. 2022;57(SUPPL 1):264
- Conference publication: ONCOLOGY RESEARCH AND TREATMENT. 2022;45(SUPPL 2):159
- Letter: LEUKEMIA. 2021;35(12):3585-3588
- Conference publication: BLOOD. 2021;138:2818
- Conference publication: BLOOD. 2021;138:1809
- Conference publication: BLOOD. 2021;138:1787
- Conference publication: BONE MARROW TRANSPLANTATION. 2021;56(SUPPL 1):327-328
- Conference publication: BONE MARROW TRANSPLANTATION. 2021;56(SUPPL 1):42-43
- Letter: BRITISH JOURNAL OF HAEMATOLOGY. 2020;189(5):e213-e217
- Letter: ANNALS OF HEMATOLOGY. 2020;99(4):899-901
- Conference publication: TRANSPLANTATION AND CELLULAR THERAPY. 2020;26(3):S286
- Conference publication: ONCOLOGY RESEARCH AND TREATMENT. 2020;43(SUPPL 4):58
- Conference publication: BONE MARROW TRANSPLANTATION. 2020;55(SUPPL 1):470-471
- Conference publication: BONE MARROW TRANSPLANTATION. 2020;55(SUPPL 1):457-458
- Conference publication: BONE MARROW TRANSPLANTATION. 2020;55(SUPPL 1):467-468
- Conference publication: BONE MARROW TRANSPLANTATION. 2020;55(SUPPL 1):23-24
- Conference publication: BONE MARROW TRANSPLANTATION. 2020;55(SUPPL 1):109-110
- Conference publication: BONE MARROW TRANSPLANTATION. 2020;55(SUPPL 1):680
- Conference publication: BONE MARROW TRANSPLANTATION. 2020;55(SUPPL 1):113-114
- Conference publication: BLOOD. 2019;134:367
- Conference publication: BLOOD. 2019;134:3313
- Conference publication: BLOOD. 2019;134:4604
- Conference publication: CYTOTHERAPY. 2019;21(5):S20-S21
- Conference publication: TRANSPLANTATION AND CELLULAR THERAPY. 2019;25(3):s207
- Conference publication: TRANSPLANTATION AND CELLULAR THERAPY. 2019;25(3):s202
- Conference publication: TRANSPLANTATION AND CELLULAR THERAPY. 2019;25(3):s342-s343
- Conference publication: ONCOLOGY RESEARCH AND TREATMENT. 2019;42:283
- Conference publication: BLOOD. 2018;132:3474
- Corrigendum: JCI INSIGHT. 2018;3(16):124015
- Conference publication: ONCOLOGY RESEARCH AND TREATMENT. 2018;41:153
- Book chapter: HAPLOIDENTICAL TRANSPLANTATION: ADVANCES AND CONTROVERSIES IN HEMATOPOIETIC TRANSPLANTATION AND CELL THERAPY. 2018;p. 81-88
- Book chapter: HAPLOIDENTICAL TRANSPLANTATION: ADVANCES AND CONTROVERSIES IN HEMATOPOIETIC TRANSPLANTATION AND CELL THERAPY. 2018;p. 307-323
- Editorial comment: ACTA DERMATO-VENEREOLOGICA. 2017;97(3):379-380
- Book chapter: ENCYCLOPEDIA OF CANCER. 2017;p. 3487-3489
- Review: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2016;82(5):1171-1179
- Book chapter: TRANSPLANT INFECTIONS. 2016;p. 889-908
- Published conference paper: BONE MARROW TRANSPLANTATION. 2015;50:S51-S54
- Book chapter: ENCYCLOPEDIA OF CANCER. 2015;p. 1-3
- Review: CURRENT OPINION IN HEMATOLOGY. 2014;21(6):470-475
- Review: BONE MARROW TRANSPLANTATION. 2014;49(2):163-167
- Letter: INTERNATIONAL JOURNAL OF COLORECTAL DISEASE. 2012;27(12):1683-1685
- Book chapter: PRÉCIS D’HÉMATOLOGIE ET D’ONCOLOGIE. 2011;p. 820-842
- Book chapter: ENCYCLOPEDIA OF CANCER. 2011;p. 2816-2818
- Review: BONE MARROW TRANSPLANTATION. 2010;45(11):1579-1586
- Review: BONE MARROW TRANSPLANTATION. 2009;44(12):769-777
- Letter: LEUKEMIA AND LYMPHOMA. 2009;50(12):2071-2074
- Book chapter: HEMATOPOIETIC STEM CELL TRANSPLANTATION IN CLINICAL PRACTICE. 2009;p. 409-416
- Book chapter: ENCYCLOPEDIA OF CANCER. 2009;p. 2285-2286
- Book chapter: CONCISE MANUAL OF HEMATOLOGY AND ONCOLOGY. 2008;p. 802-822
- Review: CURRENT OPINION IN ONCOLOGY. 2007;19(6):586-589
- Published conference paper: BLOOD. 2007;110(5):1689-1697
- Conference publication: TRANSPLANTATION AND CELLULAR THERAPY. 2007;13(2):1-2
- Conference publication: TRANSPLANTATION AND CELLULAR THERAPY. 2006;12(2):78
- Review: EUROPEAN JOURNAL OF CANCER. 2006;42(1):24-30
- Conference publication: BLOOD. 2000;96(11):359B
- Published conference paper: GYNAKOLOGISCH-GEBURTSHILFLICHE RUNDSCHAU. 1995;35:157-160
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Grants
- Swedish Research Council1 June 2021 - 31 May 2025
- Swedish Research Council1 January 2019 - 31 December 2021
- Swedish Research Council1 January 2018 - 31 December 2020