Sara Hägg
About me
Associate Professor (Docent) in molecular epidemiology at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet.
Education- PhD in Computational Biology, Linköping University, 2009
- MSc in Molecular Biology, Stockholm University, 2003
- BSc in Computer Science, Stockholm University, 2003
Postdoc
- Genetic epidemiology, Medical epidemiology and biostatistics (MEB), KI, 2011-2014
- Molecular epidemiology, Department of medical sciences, Uppsala University, 2013-2014
Sabbatical
- Stanford University School of Medicine, 2016
Research
My main research interest is human biological aging. How to measure it in human cohorts, understanding causal pathways in aging and identify geroprotectors to repurpose for age-related diseases. Markers of human biological aging can be telomere length, epigenetic clocks, functional aging, frailty index, etc. I study such markers in longitudinal data from several twin studies of aging (SATSA, GENDER, HARMONY, OCTO-Twin, TwinGene) within the Swedish Twin Registry and also using UK biobank data and many other Swedish cohorts. Methods that I use include longitudinal modelling, causal analyses using drug target Mendelian Randomization, and large-scale genome-wide approaches. For a more detailed description of my current research please visit my project page A geroscientifc approach to study human biological aging.
Articles
- Article: GEROSCIENCE. 2024;46(5):5003-5014
- Journal article: GEROSCIENCE. 2024;:1-14
- Article: BMJ MENTAL HEALTH. 2024;27(1):e301064
- Article: GEROSCIENCE. 2024;:1-18
- Article: NATURE AGING. 2024;4(7):1014-1027
- Article: AMERICAN JOURNAL OF KIDNEY DISEASES. 2024;83(6):772-783.e1
- Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY (EJE). 2024;39(6):667-678
- Article: AGING CELL. 2024;23(6):e14132
- Article: AGING CELL. 2024;23(6):e14135
- Article: NATURE CARDIOVASCULAR RESEARCH. 2024;3(6):754-769
- Article: ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY. 2024;11(6):1393-1404
- Article: JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY. 2024;95(5):481-484
- Article: STATISTICS IN MEDICINE. 2024;43(4):731-755
- Article: GEROSCIENCE. 2024;46(1):961-968
- Article: NEUROEPIDEMIOLOGY. 2024;58(4):256-263
- Article: NATURE CARDIOVASCULAR RESEARCH. 2024;3(6):754-769
- Article: EPIGENETICS. 2023;18(1):2158285
- Article: MOLECULAR GENETICS & GENOMIC MEDICINE. 2023;11(12):e2255
- Article: BRAIN. 2023;146(12):4891-4902
- Article: HEALTH SCIENCE REPORTS. 2023;6(11):e1692
- Article: NEUROLOGY. 2023;101(5):e522-e532
- Article: AGING CELL. 2023;22(8):e13868
- Article: BRITISH JOURNAL OF CANCER. 2023;129(1):94-103
- Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY (EJE). 2023;38(7):809-819
- Article: NEUROBIOLOGY OF AGING. 2023;126:103-112
- Article: SCANDINAVIAN JOURNAL OF PUBLIC HEALTH. 2023;51(4):587-594
- Article: GEROSCIENCE. 2023;45(3):2065-2078
- Article: GEROSCIENCE. 2023;45(3):2051-2064
- Article: CARDIOVASCULAR RESEARCH (CVR). 2023;119(4):998-1007
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2023;82(3):316-323
- Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2023;78(2):333-341
- Article: ALZHEIMER'S RESEARCH AND THERAPY. 2023;15(1):5
- Article: EPIGENETICS COMMUNICATIONS. 2023;3(1):7
- Article: PLOS ONE. 2023;18(3):e0283344
- Article: GERONTOLOGY. 2023;69(4):396-405
- Article: GERONTOLOGY. 2023;69(12):1385-1393
- Article: CLINICAL NUTRITION. 2022;41(12):2973-2979
- Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY (EJE). 2022;37(12):1261-1271
- Article: CLINICAL EPIGENETICS. 2022;14(1):153
- Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2022;77(11):2311-2319
- Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2022;63:e198
- Article: EPIGENOMICS. 2022;14(18):1105-1124
- Article: NEUROLOGY. 2022;99(7):e650-e659
- Article: ATHEROSCLEROSIS. 2022;354:1-7
- Article: NATURE AGING. 2022;2(7):644-661
- Article: NATURE GENETICS. 2022;54(5):581-592
- Article: TRANSLATIONAL PSYCHIATRY. 2022;12(1):124
- Article: MOLECULAR PSYCHIATRY. 2022;27(3):1667-1675
- Journal article: NPJ PARKINSON'S DISEASE. 2022;8(1):14
- Article: SCIENTIFIC REPORTS. 2022;12(1):1330
- Article: JOURNAL OF NUTRITION. 2022;152(1):269-275
- Article: AGE AND AGEING. 2021;50(6):2174-2182
- Article: BMC MEDICINE. 2021;19(1):248
- Article: NUTRIENTS. 2021;13(10):3539
- Journal article: NPJ PARKINSON'S DISEASE. 2021;7(1):78
- Article: AGING CELL. 2021;20(9):e13459
- Article: AGING. 2021;13(13):16990-17023
- Article: GENOME BIOLOGY. 2021;22(1):194
- Article: CLINICAL EPIGENETICS. 2021;13(1):129
- Article: NATURE COMMUNICATIONS. 2021;12(1):3417
- Article: MOLECULAR PSYCHIATRY. 2021;26(6):2148-2162
- Article: HUMAN GENETICS. 2021;140(6):849-861
- Article: GEROSCIENCE. 2021;43(3):1519-1525
- Article: EPIGENOMICS. 2021;13(12):939-951
- Article: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 2021;69(5):1128-1139
- Article: CLINICAL EPIGENETICS. 2021;13(1):85
- Article: EBIOMEDICINE. 2021;66:103318
- Article: MECHANISMS OF AGEING AND DEVELOPMENT. 2021;194:111426
- Article: FRONTIERS IN RESEARCH METRICS AND ANALYTICS. 2021;6:594424
- Article: JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. 2020;21(11):1555-1559.e2
- Article: LIFE SCIENCE ALLIANCE. 2020;3(10):e202000817
- Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2020;75(10):1943-1950
- Article: AGING CELL. 2020;19(8):e13197
- Article: JOURNAL OF INTERNAL MEDICINE. 2020;288(2):234-247
- Article: PSYCHOSOMATIC MEDICINE. 2020;82(6):614-622
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2020;44(6):1397-1405
- Article: EUROPEAN JOURNAL OF NUTRITION. 2020;59(4):1763-1766
- Article: BIOLOGICAL PSYCHIATRY. 2020;87(8):708-716
- Article: CLINICAL EPIGENETICS. 2020;12(1):49
- Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2020;106(3):389-404
- Article: EUROPEAN JOURNAL OF SURGICAL ONCOLOGY. 2020;46(3):316-320
- Article: ELIFE. 2020;9:e51507
- Article: HEART. 2020;106(4):267-272
- Article: CLINICAL EPIGENETICS. 2019;11(1):187
- Journal article: INNOVATION IN AGING. 2019;3(Supplement_1):s33
- Journal article: INNOVATION IN AGING. 2019;3(Supplement_1):s32-s33
- Article: PSYCHOSOMATIC MEDICINE. 2019;81(9):799-807
- Article: EPIGENETICS. 2019;14(10):961-976
- Article: EMERGING TOPICS IN LIFE SCIENCES. 2019;3(4):411-421
- Article: ROYAL SOCIETY OPEN SCIENCE. 2019;6(6):190420
- Article: BIOGERONTOLOGY. 2019;20(3):321-329
- Article: BMC MEDICINE. 2019;17(1):94
- Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2019;74(4):582-587
- Article: NATURE GENETICS. 2019;51(3):404-413
- Article: EBIOMEDICINE. 2019;40:710-716
- Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2019;109(1):90-98
- Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2019;74(1):57-61
- Article: NATURE COMMUNICATIONS. 2018;9(1):5141
- Article: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2018;187(10):2186-2191
- Article: EPIGENETICS. 2018;13(9):975-987
- Article: NEUROBIOLOGY OF AGING. 2018;69:111-116
- Article: EPIGENETICS. 2018;13(8):866-874
- Article: NATURE GENETICS. 2018;50(7):912-919
- Journal article: REVUE D'EPIDEMIOLOGIE ET DE SANTE PUBLIQUE. 2018;66:s237
- Article: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2018;47(3):899-907
- Article: NATURE COMMUNICATIONS. 2018;9(1):2098
- Article: HUMAN MOLECULAR GENETICS. 2018;27(10):1809-1818
- Article: SCIENTIFIC REPORTS. 2018;8(1):7526
- Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2018;7(9):e007806
- Article: GENES. 2018;9(2):E78-78
- Article: NEUROLOGY. 2018;90(4):e291-e297
- Article: METHODS IN MOLECULAR BIOLOGY. 2018;1750:293-306
- Article: AGING. 2017;9(12):2629-2646
- Journal article: F1000RESEARCH. 2017;6:2145
- Article: MOLECULAR PSYCHIATRY. 2017;22(12):1680-1690
- Article: SCIENTIFIC REPORTS. 2017;7(1):13230
- Article: CIRCULATION RESEARCH. 2017;121(3):214-219
- Journal article: INNOVATION IN AGING. 2017;1(suppl_1):1333-1334
- Article: TRANSLATIONAL PSYCHIATRY. 2017;7(5):e1142
- Article: TRANSLATIONAL PSYCHIATRY. 2017;7(4):e1100
- Article: F1000RESEARCH. 2017;6:2145
- Article: AGING. 2016;8(7):1398-1415
- Article: METABOLOMICS. 2016;12(1):4
- Article: HUMAN MOLECULAR GENETICS. 2015;24(23):6849-6860
- Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2015;97(5):708-714
- Article: PLOS GENETICS. 2015;11(7):e1005230
- Article: MOLECULAR PSYCHIATRY. 2015;20(6):735-743
- Article: NATURE GENETICS. 2015;47(6):589-597
- Article: DIABETES. 2015;64(5):1841-1852
- Article: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2015;44(2):578-586
- Journal article: AMERICAN JOURNAL OF MEDICAL GENETICS, PART B: NEUROPSYCHIATRIC GENETICS. 2014;165(6):510-520
- Article: DIABETIC MEDICINE. 2014;31(7):787-793
- Article: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2014;43(3):878-886
- Article: HUMAN MOLECULAR GENETICS. 2014;23(9):2490-2497
- Article: EUROPEAN RESPIRATORY JOURNAL. 2014;43(4):983-992
- Article: PLOS GENETICS. 2014;10(2):e1004201
- Article: CELL CYCLE. 2014;13(23):3645-3658
- Journal article: EUROPEAN JOURNAL OF PUBLIC HEALTH. 2013;23(suppl_1):ckt126.355
- Article: SCIENCE. 2013;340(6139):1467-1471
- Article: ACTA PHYSIOLOGICA. 2013;208(1):88-94
- Article: DIABETES. 2013;62(4):1338-1344
- Article: NATURE GENETICS. 2013;45(4):422-427e2
- Article: PLOS MEDICINE. 2013;10(6):e1001474
- Article: BMC PUBLIC HEALTH. 2012;12:664
- Article: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2011;27(6):851-857
- Journal article: ATHEROSCLEROSIS PLUS. 2011;12(1):64
- Article: PLOS ONE. 2011;6(4):e18248
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All other publications
- Review: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2024;79(10):glad251
- Preprint: MEDRXIV. 2024;MEDRXIV
- Preprint: BIORXIV. 2024
- Review: NATURE MEDICINE. 2024;30(3):360-372
- Letter: CIRCULATION. GENOMIC AND PRECISION MEDICINE. 2024;17(1):e004232
- Preprint: RESEARCH SQUARE. 2023
- Preprint: MEDRXIV. 2023
- Corrigendum: NATURE COMMUNICATIONS. 2023;14(1):716
- Conference publication: ANNALS OF NUTRITION AND METABOLISM. 2023;79:25
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2023;31:311-312
- Conference publication: INNOVATION IN AGING. 2022;6:243
- Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2022;63:E50
- Editorial comment: NATURE MICROBIOLOGY. 2022;7(8):1106-1107
- Preprint: RESEARCH SQUARE. 2022
- Preprint: MEDRXIV. 2022
- Letter: CLINICAL NUTRITION. 2022;41(2):573-574
- Editorial comment: NATURE AGING. 2022;2(2):102-104
- Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2022;29:146
- Conference publication: ARTHRITIS & RHEUMATOLOGY. 2022;74:1207-1209
- Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2022;28(3_SUPPL):212
- Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2022;29:692
- Conference publication: INNOVATION IN AGING. 2021;5:5
- Preprint: MEDRXIV. 2021
- Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2021;51:E109-E110
- Review: JOURNAL OF INTERNAL MEDICINE. 2021;290(3):602-620
- Corrigendum: HUMAN GENETICS. 2021;140(6):863
- Review: ELIFE. 2021;10:e63425
- Preprint: RESEARCH SQUARE. 2021
- Preprint: MEDRXIV. 2021
- Preprint: BIORXIV. 2021
- Preprint: BIORXIV. 2020
- Preprint: BIORXIV. 2020
- Corrigendum: NATURE GENETICS. 2020;52(3):354
- Conference publication: BEHAVIOR GENETICS. 2020;50(6):485-487
- Preprint: BIORXIV. 2019
- Preprint: MEDRXIV. 2019
- Preprint: BIORXIV. 2019
- Corrigendum: NATURE COMMUNICATIONS. 2019;10(1):2068
- Review: CURRENT OPINION IN CARDIOLOGY. 2019;34(3):270-274
- Preprint: BIORXIV. 2019
- Preprint: BIORXIV. 2019
- Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019;29:S218-S219
- Conference publication: BEHAVIOR GENETICS. 2019;49(6):532
- Conference publication: BEHAVIOR GENETICS. 2019;49(6):527
- Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019;29:1114
- Conference publication: BEHAVIOR GENETICS. 2019;49(6):515
- Conference publication: BEHAVIOR GENETICS. 2019;49(6):508-509
- Conference publication: BEHAVIOR GENETICS. 2019;49(6):503
- Review: AGEING RESEARCH REVIEWS. 2018;48:11-20
- Editorial comment: CIRCULATION RESEARCH. 2018;122(4):546-547
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2018;26:749-750
- Conference publication: HUMAN GENOMICS. 2018;12
- Preprint: BIORXIV. 2017
- Preprint: BIORXIV. 2017
- Preprint: BIORXIV. 2017
- Review: EBIOMEDICINE. 2017;21:29-36
- Preprint: BIORXIV. 2017
- Conference publication: BEHAVIOR GENETICS. 2017;47(6):706
- Conference publication: BEHAVIOR GENETICS. 2017;47(6):709
- Letter: JAMA NEUROLOGY. 2015;72(10):1202-1203
- Conference publication: BEHAVIOR GENETICS. 2015;45(6):664
- Conference publication: THE GERONTOLOGIST. 2015;55
- Conference publication: ATHEROSCLEROSIS. 2014;235(2):E29
- Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2013;42
- Conference publication: DIABETOLOGIA. 2013;56:S60
- Conference publication: CIRCULATION. 2012;126(21)
- Conference publication: GENETIC EPIDEMIOLOGY. 2012;36(7):776-777
- Conference publication: ATHEROSCLEROSIS SUPPLEMENTS. 2011;12(1):64
- Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2006;7(3):357
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Grants
- Swedish Research Council1 January 2024 - 31 December 2026
- Swedish Research Council1 January 2023 - 31 December 2027
- Swedish Research Council1 January 2023 - 31 December 2025
- Swedish Research Council1 January 2023 - 31 December 2025
- Swedish Research Council1 December 2021 - 30 November 2025
- Swedish Research Council1 December 2021 - 30 November 2025
- Swedish Research Council1 January 2021 - 31 December 2024
- Swedish Research Council1 January 2021 - 31 December 2023
- Swedish Research Council1 January 2020 - 31 December 2022
- Swedish Research Council1 January 2017 - 31 December 2019
- Swedish Research Council1 January 2016 - 31 December 2019
- Deutsche Forschungsgemeinschaft1 January 2016
- Swedish Research Council1 January 2013 - 31 December 2016
Employments
- Senior Lecturer, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2023-
Degrees and Education
- Docent, Karolinska Institutet, 2015
Leadership and responsibility assignments
- Director of core facility, LifeGene, Karolinska Institute, https://ki.se/forskning/lifegene, 2024-
- Founding board member, The Nordic Aging Society (NAS), University of Copenhagen, https://www.nordicaging.org/, 2023-
Supervisor
- Karolina Gustavsson, Muti-omics of aging and risk for dementia, 2024
- Bowen Tang
- Katalin Vincze
- Sara Licaj
Committee work
- Chair, Expert group, Swedish Twin Registry, Karolinska Institute, https://ki.se/en/research/staff-and-management
- Member, Steering committee, SIMPLER, Uppsala University, https://www.simpler4health.se/about-us/steering-committe/
- Member, Executive group, Strategic research area in epidemiology and biostatistics, Karolinska Institute, https://ki.se/en/research/about-sfoepi
Editorial work
- Clinical epigenetics, Associate editor, https://clinicalepigeneticsjournal.biomedcentral.com/about/editorial-board, 2023
Other expert reviewer/evaluation assignment
- Evaluator of research applications in national competition, Swedish Research Council, 2024
- Reviewer of candidates proposed for academic positions, University of Oulu, 2024
- Evaluator of research applications in national competition, Public Health panel, Academy of Finland, 2023
- Reviewer of candidates proposed for academic positions, Evaluator for fellowship, Medical Research Council, 2023
- Evaluator of research applications in international competition, Different panels, National Institute on Aging, 2018
Conference/event participation
- Chair, Gordon Research Conference (GRC) in Systems Aging, https://www.grc.org/systems-aging-conference/2024/, 2024
- Chair, SFOepi conference - the future of epidemiology and biostatistics, https://ki.se/en/research/sfoepi-conference-the-future-of-epidemiology-and-biostatistics, 2024
- Chair, The Nordic Aging Society - Symposium on Aging, 2024
- Other, The Nordic Congress on Gerontology, Member of the National Scientific Committee, https://www.nkg2024.se/national-scientific-committee/, 2024
- Invited speaker, Aging Research and Drug Development (ARDD), https://agingpharma.org/, 2024
- Invited speaker, Biomarkers of Aging Conference, https://www.agingconsortium.org/conference-2024, 2024
- Invited speaker, Max Planck Freiburg Epigenetics meeting, https://events.ie-freiburg.mpg.de/, 2024