Mtakai Ngara
Postdoktor
E-postadress: mtakai.ngara@ki.se
Besöksadress: Solnavägen 9, C9, 17165 Solna
Postadress: C1 Mikrobiologi, tumör- och cellbiologi, C1 Parasitology and CF Nylén, 171 77 Stockholm
Del av:
- Group 851525
- Susanne Nyléns grupp
Artiklar
- Article: BMJ PUBLIC HEALTH. 2024;2(2):e001557Ko YK; Kagaya W; Chan CW; Kanamori M; Mbugua SM; Rotich AK; Kanoi BN; Ngara M; Gitaka J; Kaneko A
- Article: TROPICAL MEDICINE AND HEALTH. 2024;52(1):52Omondi P; Musyoka B; Okai T; Kongere J; Kagaya W; Chan CW; Ngara M; Kanoi BN; Kido Y; Gitaka J; Kaneko A
- Article: DRUG METABOLISM AND PHARMACOKINETICS. 2024;57:101029Musyoka K; Chan CW; Rico EMG; Omondi P; Kijogi C; Okai T; Kongere J; Ngara M; Kagaya W; Kanoi BN; Hiratsuka M; Kido Y; Gitaka J; Kaneko A
- Article: DIABETOLOGIA. 2024;67(2):356-370Miskelly MG; Lindqvist A; Piccinin E; Hamilton A; Cowan E; Nergård B-J; Del Giudice R; Ngara M; Cataldo LR; Kryvokhyzha D; Volkov P; Engelking L; Artner I; Lagerstedt JO; Eliasson L; Ahlqvist E; Moschetta A; Hedenbro J; Wierup N
- Article: ISCIENCE. 2023;26(12):108416Lindqvist A; Abels M; Shcherbina L; Ngara M; Kryvokhyzha D; Chriett S; Riva M; Fajul A; Barghouth M; Luan C; Eliasson L; Larsen O; Rosenkilde MM; Zhang E; Renström E; Wierup N
- Article: SCIENTIFIC REPORTS. 2023;13(1):11416Osborne A; Phelan JE; Kaneko A; Kagaya W; Chan C; Ngara M; Kongere J; Kita K; Gitaka J; Campino S; Clark TG
- Article: TRIALS. 2023;24(1):354Kagaya W; Chan CWW; Kongere J; Kanoi BNN; Ngara M; Omondi P; Osborne A; Barbieri L; Kc A; Minakawa N; Gitaka J; Kaneko A
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2023;133(4):e163612Bacos K; Perfilyev A; Karagiannopoulos A; Cowan E; Ofori JK; Bertonnier-Brouty L; Rönn T; Lindqvist A; Luan C; Ruhrmann S; Ngara M; Nilsson Å; Gheibi S; Lyons CL; Lagerstedt JO; Barghouth M; Esguerra JL; Volkov P; Fex M; Mulder H; Wierup N; Krus U; Artner I; Eliasson L; Prasad RB; Cataldo LR; Ling C
- Article: SCIENTIFIC REPORTS. 2021;11(1):19809Osborne A; Manko E; Takeda M; Kaneko A; Kagaya W; Chan C; Ngara M; Kongere J; Kita K; Campino S; Kaneko O; Gitaka J; Clark TG
- Article: EXPERIMENTAL CELL RESEARCH. 2018;371(1):130-138Ngara M; Palmkvist M; Sagasser S; Hjelmqvist D; Bjorklund AK; Wahlgren M; Ankarklev J; Sandberg R
- Article: PLOS ONE. 2016;11(7):e0154102Astakhova L; Ngara M; Babich O; Prosekov A; Asyakina L; Dyshlyuk L; Midtvedt T; Zhou X; Ernberg I; Matskova L
- Article: CANCER CELL. 2014;25(6):794-808Woll PS; Kjallquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstrom-Lindberg E; Linnarsson S; Jacobsen SEW
Alla övriga publikationer
- Preprint: MEDRXIV. 2024Ko Y; Kagaya W; Chan C; Kanamori M; Mbugua S; Rotich A; Kanoi B; Ngara M; Gitaka J; Kaneko A
- Preprint: RESEARCH SQUARE. 2023Kagaya W; Chan CW; Kongere J; Kanoi BN; Ngara M; Omondi P; Osborne A; Barbieri L; Kc A; Minakawa N; Gitaka J; Kaneko A
- Review: DIABETOLOGIA. 2022;65(8):1241-1250Ngara M; Wierup N
- Doctoral thesis: 2019Ngara M
- Editorial comment: PLOS COMPUTATIONAL BIOLOGY. 2010;6(2):e1000650Gichora NN; Fatumo SA; Ngara MV; Chelbat N; Ramdayal K; Opap KB; Siwo GH; Adebiyi MO; El Gonnouni A; Zofou D; Maurady AAM; Adebiyi EF; de Villiers EP; Masiga DK; Bizzaro JW; Suravajhala P; Ommeh SC; Hide W
Forskningsbidrag
- Swedish Research Council1 January 2023 - 31 December 2026Despite effective control tools, malaria elimination remains elusive in tropical Africa. In endemic areas many infected individuals are asymptomatic and submicroscopic that go undiagnosed and untreated but still sustain transmission. Interactions among parasites, mosquitos, and humans are key for the control and maintenance of these low-density infection, however yet to understand the mechanisms behind. Naturally acquired immunity through repeated exposure to parasites can suppress parasite density and protect individuals from severe disease, but the mechanism of immunity acquisition in relation to T cell subsets remains unexplored. Parasites indirectly change the blood seeking behavior of mosquitos by inducing volatile compounds from infected humans, but the link with the parasite density is missing. Using a longitudinal cohort in Lake Victoria, Kenya, we aim to (1) characterize asymptomatic and submicroscopic infection together with the risk factors in eco-epidemiological context, (2) compare the transcriptomes of CD8+ T cells at the single cell level to identify factors that mediate disease severity, and (3) identify behavioral modifiers which explain the increased attractiveness of people carrying various density of parasite. With a focus on asymptomatic and submicroscopic infections, this study seeks to understand how residual transmission persists, with potential implications for development of novel tools and strategies for malaria elimination in tropical Africa.
- Swedish Research Council1 January 2021 - 31 December 2023
Anställningar
- Postdoktor, Institutionen för mikrobiologi, tumör- och cellbiologi, Karolinska Institutet, 2022-2026
Examina och utbildning
- Medicine Doktorsexamen, Institutionen för cell- och molekylärbiologi, Karolinska Institutet, 2019