Mtakai Ngara
Research
Every cell is unique and generates distinct molecular response(s) in disease.
Understanding these perturbations at single cell resolution is critical in
unravelling complex, yet important diseases such as malaria.
In areas of endemic malaria transmission, individuals living in
geographically defined regions often present distinct phenotypes when
infected by the Plasmodium falciparum. I am interested in applying a systems
approach to understanding how immune cells define the three key outcomes of
malaria infection namely: asymptomatic, mild and symptomatic. To this end, we
will adopt single cell RNA-seq and other genome-wide technologies to profile
T lymphocytes derived from a high-resolution longitudinal cohort from Lake
Victoria islands in Kenya. This will provide an opportunity to gain novel
insight(s) into the disease in field transmission context and enhance our
understanding of the main drivers of adaptive response to malaria infection.
Articles
- Journal article: TROPICAL MEDICINE AND HEALTH. 2024;52(1):52
- Journal article: DRUG METABOLISM AND PHARMACOKINETICS. 2024;57:101029
- Article: DIABETOLOGIA. 2024;67(2):356-370
- Article: ISCIENCE. 2023;26(12):108416
- Article: SCIENTIFIC REPORTS. 2023;13(1):11416
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2023;133(4):e163612
- Article: SCIENTIFIC REPORTS. 2021;11(1):19809
- Article: EXPERIMENTAL CELL RESEARCH. 2018;371(1):130-138
- Article: PLOS ONE. 2016;11(7):e0154102
- Article: CANCER CELL. 2014;25(6):794-808
All other publications
- Review: DIABETOLOGIA. 2022;65(8):1241-1250
- Thesis / dissertation: 2019
- Editorial comment: PLOS COMPUTATIONAL BIOLOGY. 2010;6(2):e1000650
Grants
- Swedish Research Council1 January 2023 - 31 December 2026
- Swedish Research Council1 January 2021 - 31 December 2023
Employments
- Postdoctoral Researcher, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2022-2025
Degrees and Education
- Degree Of Doctor Of Philosophy, Department of Cell and Molecular Biology, Karolinska Institutet, 2019