Johan Högberg
Professor Emeritus/Emerita
E-postadress: johan.hogberg@ki.se
Telefon: +46852487783
Besöksadress: Nobels väg 13, 17177 Stockholm
Postadress: C6 Institutet för miljömedicin, C6 Biokemisk toxikologi Stenius, 171 77 Stockholm
Om mig
Ongoing research projects:
- Gender differences in carcinogenesis (supported by Formas)
- Low-dose genotoxic effects of crystalline silica particles (supported
by AFA).- New type of DNA damage induced by chrystalline siliuca particles: does anti-androgenic carcinogens increase men´s sensitivity ti silica? (supported by Forte 2025 - 2027).
Forskningsbeskrivning
- Recent selected publications:
Approaches for the setting of occupational exposure limits (OELs) for
carcinogens. [1]
*Högberg J*, Järnberg J.Crit Rev Toxicol. 2023 Dec;53(3):131-167. doi:
10.1080/10408444.2023.2218887. Epub 2023 Jun 27.PMID: 37366107 Review
ATX-LPA-Dependent Nuclear Translocation of Endonuclease G in Respiratory
Epithelial Cells: A New Mode Action for DNA Damage Induced by Crystalline
Silica Particles. [2]
Zheng H, Stenius U, *Högberg J.*Cancers (Basel). 2023 Jan 30;15(3):865.
doi: 10.3390/cancers15030865.PMID: 36765823.
Application of Text Mining in Risk Assessment of Chemical Mixtures: A Case
Study of Polycyclic Aromatic Hydrocarbons (PAHs). [3]
Ali I, Dreij K, Baker S, *Högberg J*, Korhonen A, Stenius U.Environ Health
Perspect. 2021 Jun;129(6):67008. doi: 10.1289/EHP6702. Epub 2021 Jun
24.PMID: 34165340.
Crystalline silica particles induce DNA damage in respiratory epithelium by
ATX secretion and Rac1 activation. [4]
Wu R, *Högberg J*, Adner M, Stenius U, Zheng H.Biochem Biophys Res Commun.
2021 Apr 9;548:91-97. doi: 10.1016/j.bbrc.2021.02.020. Epub 2021 Feb
23.PMID: 33636640.
Crystalline silica particles cause rapid NLRP3-dependent mitochondrial
depolarization and DNA damage in airway epithelial cells. [5]
Wu R, *Högberg J*, Adner M, Ramos-Ramírez P, Stenius U, Zheng H.Part Fibre
Toxicol. 2020 Aug 10;17(1):39. doi:
10.1186/s12989-020-00370-2.PMID: 32778128.
[1] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/37366107/
[2] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/36765823/
[3] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/34165340/
[4] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/33636640/
[5] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/32778128/
Artiklar
- Article: CANCERS. 2023;15(3):865Zheng H; Stenius U; Hoegberg J
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2021;129(6):67008Ali I; Dreij K; Baker S; Hogberg J; Korhonen A; Stenius U
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2021;548:91-97Wu R; Hogberg J; Adner M; Stenius U; Zheng H
- Article: JOURNAL OF IMMUNOTOXICOLOGY. 2021;18(1):74-84Karri V; Liden C; Fyhrquist N; Hogberg J; Karlsson HL
- Article: PARTICLE AND FIBRE TOXICOLOGY. 2020;17(1):39Wu R; Hogberg J; Adner M; Ramos-Ramirez P; Stenius U; Zheng H
- Article: BIOMEDICINE & PHARMACOTHERAPY. 2020;127:110112Ghalali A; Ye Z-W; Hogberg J; Stenius U
- Journal article: EXCLI JOURNAL. 2020;19:490-491Hogberg J
- Article: BIOINFORMATICS. 2019;35(9):1553-1561Pyysalo S; Baker S; Ali I; Haselwimmer S; Shah T; Young A; Guo Y; Hogberg J; Stenius U; Narita M; Korhonen A
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2018;355:43-51Brostrom JM; Ghalali A; Zheng H; Hogberg J; Stenius U; Littorin M; Tinnerberg H; Broberg K
- Article: BIOINFORMATICS. 2017;33(24):3973-3981Baker S; Ali I; Silins I; Pyysalo S; Guo Y; Hogberg J; Stenius U; Korhonen A
- Article: CARCINOGENESIS. 2017;38(12):1196-1206Zheng H; Hogberg J; Stenius U
- Article: MOLECULAR CANCER RESEARCH. 2017;15(6):714-722Ghalali A; Martin-Renedo J; Hogberg J; Stenius U
- Journal article: CHEMICO-BIOLOGICAL INTERACTIONS. 2017;268:148Al-Anati L; Kadekar S; Hogberg J; Stenius U
- Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2016;291(51):26588Malmlöf M; Roudier E; Högberg J; Stenius U
- Article: CARCINOGENESIS. 2016;37(12):1144-1151Ali I; Julin B; Glynn A; Hogberg J; Berglund M; Johansson J-E; Andersson S-O; Andren O; Giovannucci E; Wolk A; Stenius U; Akesson A
- Article: CARCINOGENESIS. 2016;37(10):985-992Ali I; Hogberg J; Hsieh J-H; Auerbach S; Korhonen A; Stenius U; Silins I
- Article: BIOINFORMATICS. 2016;32(3):432-440Baker S; Silins I; Guo Y; Ali I; Hogberg J; Stenius U; Korhonen A
- Article: TOXICOLOGY LETTERS. 2016;241:32-37Ali I; Guo Y; Silins I; Hogberg J; Stenius U; Korhonen A
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2015;287(3):222-231Brostrom JM; Ye Z-W; Axmon A; Littorin M; Tinnerberg H; Lindh CH; Zheng H; Ghalali A; Stenius U; Jonsson BAG; Hogberg J
- Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2015;239:164-173Al-Anati L; Viluksela M; Strid A; Bergman A; Andersson PL; Stenius U; Hogberg J
- Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2014;219:159-167Al-Anati L; Kadekar S; Hogberg J; Stenius U
- Article: CARCINOGENESIS. 2014;35(7):1547-1555Ghalali A; Wiklund F; Zheng H; Stenius U; Hogberg J
- Article: TOXICOLOGIC PATHOLOGY. 2012;40(8):1160-1168Kadekar S; Peddada S; Silins I; French JE; Hogberg J; Stenius U
- Article: JOURNAL OF RADIOLOGICAL PROTECTION. 2012;32(4):439-446Högberg J; Rizell M; Hultborn R; Svensson J; Henrikson O; Gjertsson P; Bernhardt P
- Article: PLOS ONE. 2012;7(8):e43209Kadekar S; Silins I; Korhonen A; Dreij K; Al-Anati L; Hogberg J; Stenius U
- Article: INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT. 2012;8(3):412-417Silins I; Korhonen A; Hogberg J; Stenius U
- Article: PLOS ONE. 2012;7(4):e33427Korhonen A; Seaghdha DO; Silins I; Sun L; Hogberg J; Stenius U
- Article: CLINICA CHIMICA ACTA. 2012;413(7-8):727-732Leander K; Gigante B; Silveira A; Vikstrom M; Hamsten A; Hogberg J
- Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2012;40(3):867-875Miraglia E; Hogberg J; Stenius U
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;415(4):613-618Ye Z-W; Ghalali A; Hogberg J; Stenius U
- Article: BMC BIOINFORMATICS. 2011;12:69Guo Y; Korhonen A; Liakata M; Silins I; Hogberg J; Stenius U
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2010;249(2):166-177Al-Anati L; Hogberg J; Stenius U
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(36):27900-27910Mistafa O; Ghalali A; Kadekar S; Hogberg J; Stenius U
- Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2009;182(2-3):191-198Al-Anati L; Hogberg J; Stenius U
- Article: TOXICOLOGICAL SCIENCES. 2008;102(2):232-240Malmlof M; Paajarvi G; Hogberg J; Stenius U
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2008;116(3):334-339Hogberg J; Hanberg A; Berglund M; Skerfving S; Remberger M; Calafat AM; Filipsson AF; Jansson B; Johansson N; Appelgren M; Hakansson H
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2008;365(1):131-136Mistafa O; Hoegberg J; Stenius U
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(4):2288-2296Malmlof M; Roudier E; Hogberg J; Stenius U
- Article: FOOD AND CHEMICAL TOXICOLOGY. 2006;44(9):1552-1561Silins I; Hogberg J; Stenius U
- Article: FASEB JOURNAL. 2005;18(15):476-478Pääjärvi G; Roudier E; Crisby M; Högberg J; Stenius U
- Article: CARCINOGENESIS. 2005;26(1):201-208Pääjärvi G; Viluksela M; Pohjanvirta R; Stenius U; Högberg J
- Article: ARCHIVES OF TOXICOLOGY. 2004;78(9):540-548Silins I; Stenius U; Högberg J
- Article: ANNALS OF OCCUPATIONAL HYGIENE. 2004;48(4):339-349Svedberg URA; Högberg HE; Högberg J; Galle B
- Article: CANCER LETTERS. 2004;207(2):149-155Finnberg N; Stenius U; Högberg J
- Article: CARCINOGENESIS. 2004;25(1):113-122Finnberg N; Silins I; Stenius U; Högberg J
- Article: CARCINOGENESIS. 2003;24(6):1077-1083Silins I; Nordstrand M; Högberg J; Stenius U
- Article: CARCINOGENESIS. 2001;22(12):2023-2031Silins I; Finnberg N; Ståhl A; Högberg J; Stenius U
- Journal article: HEPATOLOGY. 2001;33(2):480-481Högberg J; Stenius U
- Article: TOXICOLOGICAL SCIENCES. 2000;54(1):95-103Finnberg N; Stenius U; Högberg J
- Article: HYBRIDOMA. 2000;19(1):63-72Thullberg M; Welcker M; Bartkova J; Kjerulff AA; Lukas J; Högberg J; Bartek J
- Article: CELL BIOLOGY AND TOXICOLOGY. 1999;15(1):31-39Lennartsson P; Stenius U; Högberg J
- Journal article: CARCINOGENESIS. 1999;20(1):181-182Stenius U; Högberg J
- Article: CANCER LETTERS. 1998;134(1):103-109Stenius U; Högberg J
- Journal article: TOXICOLOGY LETTERS. 1998;95:180Stenius U; Lennartsson P; Högberg J
- Article: CARCINOGENESIS. 1998;19(7):1231-1237Lennartsson P; Högberg J; Stenius U
- Article: CANCER LETTERS. 1998;128(1):1-10Thullberg M; Grasl-Kraupp B; Högberg J; Garberg P
- Article: TOXICOLOGY IN VITRO. 1998;12(3):279-285Stenius U; Stahl A; Hogberg J
- Article: CANCER LETTERS. 1996;104(1):21-26Martens U; Lennartsson P; Högberg J; Stenius U
- Article: TOXICOLOGY IN VITRO. 1995;9(6):937-943Warholm M; Stenius U; Ståhl A; Högberg J
- Journal article: EPIDEMIOLOGY. 1995;6(2):s47Högberg J; Alexandrie AK; Sigvardsson K; Warholm M; Rannug A
- Journal article: PHARMACOGENETICS AND GENOMICS. 1994;4(6):307-312Warholm M; Alexandrie AK; Högberg J; Sigvardsson K; Rannug A
- Journal article: CARCINOGENESIS. 1994;15(8):1561-1566Stenius U; Warholm M; Martens U; Högberg J
- Journal article: CARCINOGENESIS. 1990;11(1):69-73Stenius U; Rubin K; Gullberg D; Högberg J
- Journal article: CARCINOGENESIS. 1989;10(3):593-599Stenius U; Warholm M; Rannug A; Walles S; Lundberg I; Högberg J
- Journal article: BIOCHEMICAL PHARMACOLOGY. 1988;37(18):3401-3406Garberg P; Ståhl A; Warholm M; Högberg J
- Journal article: CARCINOGENESIS. 1988;9(7):1223-1228Stenius U; Högberg J
- Journal article: CHEMICO-BIOLOGICAL INTERACTIONS. 1988;67(1-2):25-31Ekström T; Warholm M; Kronevi T; Högberg J
- Journal article: CHEMICO-BIOLOGICAL INTERACTIONS. 1988;66(3-4):177-187EKSTROM T; GARBERG P; EGESTAD B; HOGBERG J
- Journal article: CANCER LETTERS. 1987;36(1):29-33Lundberg I; Högberg J; Kronevi T; Holmberg B
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Alla övriga publikationer
- Review: CRITICAL REVIEWS IN TOXICOLOGY. 2023;53(3):131-167Hogberg J; Jarnberg J
- Review: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 2011;8(3):629-647Silins I; Hogberg J
- Conference publication: EUROPEAN HEART JOURNAL. 2010;31:537Leander K; Gigante B; Hogberg J
- Conference publication: CANCER RESEARCH. 2010;70:1687Kadekar S; Silins I; Hogberg J; Dreij K; Stenius U
- Meeting abstract: EPIDEMIOLOGY. 2009;20(6):S175Grelher J; Gasparrini A; Merilainen P; Villanueva C; Kuhn A; Fletcher T; Vartiainen T; Kogevinas M; Hogberg J; Bernard A; Nieuwenhuijsen M
- Conference publication: CANCER RESEARCH. 2009;69Silins I; Korhonen A; Hogberg J; Sun L; Stenius U
- Review: EXS. 2009;99:181-208Högberg J; Silins I; Stenius U
- Meeting abstract: EPIDEMIOLOGY. 2006;17(6):S299Hogberg J; Stenius U; Paajarvi G
- Conference publication: CANCER RESEARCH. 2006;66(8)Stenius U; Roudier E; Mistafa O; Hogberg J
- Letter: CRITICAL REVIEWS IN TOXICOLOGY. 2005;35(5):459-460Högberg J; Larsson K; Albin M; Järvholm B; Montelius J
- Corrigendum: ANNALS OF OCCUPATIONAL HYGIENE. 2004;48(4):381Svedberg URA; Högberg HR; Högberg J; Galle B
- Conference publication: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 2002;11(10):1213SHögberg J; Stenius U; Silins I
- Published conference paper: TOXICOLOGY IN VITRO. 1998;12(5):607-610Lennartsson P; Stenius U; Hogberg J
- Published conference paper: ATLA-ALTERNATIVES TO LABORATORY ANIMALS. 1996;24(3):393-397Stenius U; Martens U; Hogberg J
- Other: CARCINOGENESIS. 1995;16(8):1683-1686Stenius U; Högberg J
- Book chapter: SELENIUM IN BIOLOGY AND MEDICINE. 1989;p. 74-78Högberg J; Garberg P; Ståhl A
Forskningsbidrag
- Swedish Research Council for Environment Agricultural Sciences and Spatial Planning1 January 2023 - 31 December 2025Men have higher cancer incidences than women. Lifetime risk for men is 50% and for women 30% and an incidence quote of 1.8 for men/women has been shown for cancer in non-sex organs. Calculations suggest that a third of all cancer cases should be possible to eliminate if causes were known and could be eliminated. Further support for differences is that men have worse survival statistics and that boys have worse cancer prognosis. We have found that skin carcinogens inactivate androgen receptor (AR) in human stem cells. In the present project we will study if carcinogen-induced inactivation of androgen receptor (AR) in human stem cells can explain men’s susceptibility to cancer, and in particular the high incidence for older men. We will 1) investigate how environmental carcinogens inactivate AR, 2) analyze the consequences of AR inactivation concerning DNA damage and repair, 3) study if carcinogens interact with age-dependent decline in testosterone levels and increase DNA damage and mutation burden, and 4) analyze differences in tumor-specific mutational burden between genders. Our study will hopefully explain a major risk factor behind melanoma and perhaps also men´s cancer susceptibility for several other tumors. Our study may also suggest tools to decrease men´s cancer incidence, as well as the total cancer incidence, via a development of new risk assessment strategies.
- Swedish Research Council for Health Working Life and Welfare1 January 2019 - 31 December 2021
Anställningar
- Professor Emeritus/Emerita, Institutet för miljömedicin, Karolinska Institutet, 2025-2028
- Professor, Institutet för miljömedicin, Karolinska Institutet, 2021-2025
Examina och utbildning
- Docent, Rättsmedicin, Karolinska Institutet, 1978