Johan Högberg

Johan Högberg

Professor Emeritus/Emerita
E-postadress: johan.hogberg@ki.se
Telefon: +46852487783
Besöksadress: Nobels väg 13, 17177 Stockholm
Postadress: C6 Institutet för miljömedicin, C6 Biokemisk toxikologi Stenius, 171 77 Stockholm

Om mig

  • Ongoing research projects:
    - Gender differences in carcinogenesis (supported by Formas)
    - Low-dose genotoxic effects of crystalline silica particles (supported
    by AFA).

    - New type of DNA damage induced by chrystalline siliuca particles: does anti-androgenic carcinogens increase men´s sensitivity ti silica? (supported by Forte 2025 - 2027).

     

Forskningsbeskrivning

  • Recent selected publications:
    Approaches for the setting of occupational exposure limits (OELs) for
    carcinogens. [1]
    *Högberg J*, Järnberg J.Crit Rev Toxicol. 2023 Dec;53(3):131-167. doi:
    10.1080/10408444.2023.2218887. Epub 2023 Jun 27.PMID: 37366107 Review
    ATX-LPA-Dependent Nuclear Translocation of Endonuclease G in Respiratory
    Epithelial Cells: A New Mode Action for DNA Damage Induced by Crystalline
    Silica Particles. [2]
    Zheng H, Stenius U, *Högberg J.*Cancers (Basel). 2023 Jan 30;15(3):865.
    doi: 10.3390/cancers15030865.PMID: 36765823.
    Application of Text Mining in Risk Assessment of Chemical Mixtures: A Case
    Study of Polycyclic Aromatic Hydrocarbons (PAHs). [3]
    Ali I, Dreij K, Baker S, *Högberg J*, Korhonen A, Stenius U.Environ Health
    Perspect. 2021 Jun;129(6):67008. doi: 10.1289/EHP6702. Epub 2021 Jun
    24.PMID: 34165340.
    Crystalline silica particles induce DNA damage in respiratory epithelium by
    ATX secretion and Rac1 activation. [4]
    Wu R, *Högberg J*, Adner M, Stenius U, Zheng H.Biochem Biophys Res Commun.
    2021 Apr 9;548:91-97. doi: 10.1016/j.bbrc.2021.02.020. Epub 2021 Feb
    23.PMID: 33636640.
    Crystalline silica particles cause rapid NLRP3-dependent mitochondrial
    depolarization and DNA damage in airway epithelial cells. [5]
    Wu R, *Högberg J*, Adner M, Ramos-Ramírez P, Stenius U, Zheng H.Part Fibre
    Toxicol. 2020 Aug 10;17(1):39. doi:
    10.1186/s12989-020-00370-2.PMID: 32778128.
    [1] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/37366107/
    [2] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/36765823/
    [3] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/34165340/
    [4] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/33636640/
    [5] https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/32778128/

Artiklar

Alla övriga publikationer

Forskningsbidrag

  • Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
    1 January 2023 - 31 December 2025
    Men have higher cancer incidences than women. Lifetime risk for men is 50% and for women 30% and an incidence quote of 1.8 for men/women has been shown for cancer in non-sex organs. Calculations suggest that a third of all cancer cases should be possible to eliminate if causes were known and could be eliminated. Further support for differences is that men have worse survival statistics and that boys have worse cancer prognosis. We have found that skin carcinogens inactivate androgen receptor (AR) in human stem cells. In the present project we will study if carcinogen-induced inactivation of androgen receptor (AR) in human stem cells can explain men’s susceptibility to cancer, and in particular the high incidence for older men. We will 1) investigate how environmental carcinogens inactivate AR, 2) analyze the consequences of AR inactivation concerning DNA damage and repair, 3) study if carcinogens interact with age-dependent decline in testosterone levels and increase DNA damage and mutation burden, and 4) analyze differences in tumor-specific mutational burden between genders. Our study will hopefully explain a major risk factor behind melanoma and perhaps also men´s cancer susceptibility for several other tumors. Our study may also suggest tools to decrease men´s cancer incidence, as well as the total cancer incidence, via a development of new risk assessment strategies.
  • Swedish Research Council for Health Working Life and Welfare
    1 January 2019 - 31 December 2021

Anställningar

  • Professor Emeritus/Emerita, Institutet för miljömedicin, Karolinska Institutet, 2025-2028
  • Professor, Institutet för miljömedicin, Karolinska Institutet, 2021-2025

Examina och utbildning

  • Docent, Rättsmedicin, Karolinska Institutet, 1978

Nyheter från KI

Kalenderhändelser från KI