Johan Högberg

Johan Högberg

Professor | Docent
Telephone: +46852487783
Visiting address: Nobels väg 13, 17177 Stockholm
Postal address: C6 Institutet för miljömedicin, C6 Biokemisk toxikologi Stenius, 171 77 Stockholm


  • *Occupational toxicology and risk assessment*
    Johan Högberg is chairman for the Swedish Criteria Group which produces risk
    assessment documents used for setting legally binding occupational exposure
    limits in Sweden.
    Current projects involve the development of sensitive endpoints in the
    p53/Mdm2 network for certain types of DNA damages and for mixtures of
    compounds and mixtures of tumor initiators and tumor promoters such as TCDD
    and PCBs. We also study rapid changes in the Akt signaling pathway and how
    knowledge about this pathway can be utilized for the development of cancer
    preventive strategies in e.g. the prostate.
    In international collaboration we develop methods for integrated risk
    assessment and risk assessment of complex mixtures. Ongoing projects involve
    an analysis of cancer deaths classified as work related. Our question is how
    often these cancers can be attributed to a single chemical or to a complex
    mixture of chemicals. We also develop simplified models for rapid screening
    of risks associated with the use of chemicals.
    * Arbetslivsinstitutet
    * EUs 6:e ramprogram (INTARESE)
    * EUs 6:e ramprogram (ATHON)
    * AFA
    * FAS
    * FORMAS
    *Research group*
    * Ilona Silins, Assistant Professor
    * Lauy Al-Anati, Postdoc
    * Erica Miraglia, Postdoc
    *Five selected publications*
    *Högberg J, Hanberg A, Berglund M, Skerfving S, Remberger M, Calafat AM,
    Filipsson AF, Jansson B, Johansson N, Appelgren M, Håkansson H.*
    Phthalate diesters and their metabolites in human breast milk, blood or
    serum, and urine as biomarkers of exposure in vulnerable populations.
    Environ Health Perspect. 2008 Mar
  • 116(3):334-9
    *Mistafa O, Högberg J, Stenius U.*
    Statins and ATP regulate nuclear pAkt via the P2X7 purinergic receptor in
    epithelial cells.
    Biochem Biophys Res Commun. 2008 Jan 4
  • 365(1):131-6. Epub 2007 Oct 31.
    *Malmlöf M, Roudier R, Högberg J, Stenius U*
    MEK-ERK-mediated phosphorylation of Mdm2 at Ser 166 in hepatocytes
  • Mdm2 is
    activated in response to inhibited Akt signaling
    J Biol Chem. 2007 Jan 26
  • 282(4):2288-96
    *Pääjärvi G, Viluksela M, Pohjanvirta R, Stenius U and Högberg J. (2005)*
    TCDD modulates Mdm2 expression and alters the p53 response to DNA damage.
    Carcinogenesis, 26, 201-208.
    *Malmlöf M, Pääjärvi G, Högberg J and Stenius U. (2008)*
    Mdm2 as a sensitive and mechanistically informative marker for genotoxicity
    induced by benzo[a]pyrene and dibenzo[a, l]pyrene.
    Toxicological Sciences, 102, 232-240.


All other publications



  • Professor, Institute of Environmental Medicine, Karolinska Institutet, 2021-

Degrees and Education

  • Docent, Karolinska Institutet, 1978

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