Jakob Michaelsson

Om mig
Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Om mig

Jag leder en forskargrupp vid Centrum för infektionsmedicin på institutionen för Medicin Huddinge. Genom att förstå hur immunceller utvecklas och fungerar i de olika stadierna av vårt liv och i olika sjukdomstillstånd, hoppas vi bidra till det som är slutmålet med vår forskning – att använda immunsystemets celler för nya terapier i cancer och infektionssjukdomar.
Vi studerar framförallt hur så kallade Natural Killer (NK) celler och andra medfödda lymfocyter (ILCs) utvecklas och regleras i människans vävnader, samt hur de påverkas av olika sjukdomar, till exempel lungcancer och virusinfektioner.

Artiklar

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2025;122(6):e2414230122
Human MAIT cell response profiles biased toward IL-17 or IL-10 are distinct effector states directed by the cytokine milieu.
Boulouis C; Mouchtaridi E; Müller TR; Mak JYW; Fairlie DP; Bergman P; Michaëlsson J; Halfvarson J; Mjösberg J; Buggert M; Sandberg JK
Article: GENES AND IMMUNITY. 2025;26(1):70-74
The HLA-B-21 M/T dimorphism associates with disease severity in COVID-19
Strunz B; Momayyezi P; Bilev E; Muvva JR; Chen P; Bister J; Schaffer M; Akber M; Cornillet M; Horowitz A; Malmberg K-J; Rooyackers O; Aleman S; Ljunggren H-G; Bjorkstrom NK; Stralin K; Hammer Q
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2025;55(2):e202451150
Distinct Tissue-Dependent Composition and Gene Expression of Human Fetal Innate Lymphoid Cells
Rodahl IE; Ivarsson MA; Loh L; Mold JE; Westgren M; Friberg D; Mjosberg J; Bjorkstrom NK; Marquardt N; Nixon DF; Michaelsson J
Journal article: PLOS NEGLECTED TROPICAL DISEASES. 2025;19(2):e0012693
Antigen-specific T cell responses following single and co-administration of tick-borne encephalitis, Japanese encephalitis, and yellow fever virus vaccines: Results from an open-label, non-randomized clinical trial-cohort
Wullimann D; Sandberg JT; Akber M; Lofling M; Gredmark-Russ S; Michaelsson J; Buggert M; Blom K; Ljunggren H-G
Article: SCIENCE IMMUNOLOGY. 2024;9(99):eadn2362
MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profiles
Kammann T; Cai C; Sekine T; Mouchtaridi E; Boulouis C; Nilsen V; Ballesteros OR; Mueller TR; Gao Y; Raineri EJM; Mily A; Adamo S; Constantz C; Niessl J; Weigel W; Kokkinou E; Stamper C; Marchalot A; Bassett J; Ferreira S; Rodahl I; Wild N; Brownlie D; Tibbitt C; Mak JYW; Fairlie DP; Leeansyah E; Michaelsson J; Marquardt N; Mjosberg J; Jorns C; Buggert M; Sandberg JK
Article: JOURNAL OF INFECTIOUS DISEASES. 2024;230(2):e318-e326
Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19
Strunz B; Maucourant C; Mehta A; Wan H; Du L; Sun D; Chen P; Nordlander A; Gao Y; Cornillet M; Bister J; Kvedaraite E; Christ W; Klingstrom J; Geanon D; Parke A; Ekwall-Larson A; Rivino L; MacAry PA; Aleman S; Buggert M; Ljunggren H-G; Pan-Hammarstrom Q; Lund-Johansen F; Stralin K; Bjorkstrom NK
Article: NATURE IMMUNOLOGY. 2024;25(8):1445-1459
Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping
Netskar H; Pfefferle A; Goodridge JP; Sohlberg E; Dufva O; Teichmann SA; Brownlie D; Michaelsson J; Marquardt N; Clancy T; Horowitz A; Malmberg K-J
Article: SCIENCE IMMUNOLOGY. 2024;9(94):eadj7168
Tissue-specific nonheritable influences drive endometrial immune system variation
Bister J; Filipovic I; Sun D; Crona-Guterstam Y; Cornillet M; Ponzetta A; Michaelsson J; Gidloef S; Ivarsson MA; Strunz B; Bjoerkstroem NK
Article: CELL SYSTEMS. 2024;15(2):149-165.e10
Clonally heritable gene expression imparts a layer of diversity within cell types
Mold JE; Weissman MH; Ratz M; Hagemann-Jensen M; Hard J; Eriksson C-J; Toosi H; Berghenstrahle J; Ziegenhain C; von Berlin L; Martin M; Blom K; Lagergren J; Lundeberg J; Sandberg R; Michaeeurolsson J; Frisen J
Article: ONCOIMMUNOLOGY. 2023;12(1):2233402
Accumulation of tissue-resident natural killer cells, innate lymphoid cells, and CD8⁺ T cells towards the center of human lung tumors
Brownlie D; von Kries A; Valenzano G; Wild N; Yilmaz E; Safholm J; Al-Ameri M; Alici E; Ljunggren H-G; Schliemann I; Aricak O; de Flon FH; Michaelsson J; Marquardt N
Article: SCIENCE. 2023;382(6675):eadf8486
Spatial transcriptomics of B cell and T cell receptors reveals lymphocyte clonal dynamics
Engblom C; Thrane K; Lin Q; Andersson A; Toosi H; Chen X; Steiner E; Lu C; Mantovani G; Hagemann-Jensen M; Saarenpaa S; Jangard M; Saez-Rodriguez J; Michaelsson J; Hartman J; Lagergren J; Mold JE; Lundeberg J; Frisen J
Article: NATURE COMMUNICATIONS. 2023;14(1):5164
Long-read whole-genome analysis of human single cells
Hard J; Mold JE; Eisfeldt J; Tellgren-Roth C; Haggqvist S; Bunikis I; Contreras-Lopez O; Chin C-S; Nordlund J; Rubin C-J; Feuk L; Michaelsson J; Ameur A
Article: RESPIRATORY RESEARCH. 2023;24(1):62
Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia
Palma Medina LM; Babacic H; Dzidic M; Parke A; Garcia M; Maleki KT; Unge C; Lourda M; Kvedaraite E; Chen P; Muvva JR; Cornillet M; Emgard J; Moll K; Michaelsson J; Flodstrom-Tullberg M; Brighenti S; Buggert M; Mjosberg J; Malmberg K-JK; Sandberg J; Gredmark-Russ S; Rooyackers O; Svensson MJ; Chambers BI; Eriksson L; Pernemalm MK; Bjorkstrom N; Aleman S; Ljunggren H-G; Klingstrom J; Stralin K; Norrby-Teglund A
Article: NATURE CELL BIOLOGY. 2023;25(2):351-365
A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung
Sountoulidis A; Marco Salas S; Braun E; Avenel C; Bergenstrahle J; Theelke J; Vicari M; Czarnewski P; Liontos A; Abalo X; Andrusivova Z; Mirzazadeh R; Asp M; Li X; Hu L; Sariyar S; Martinez Casals A; Ayoglu B; Firsova A; Michaelsson J; Lundberg E; Waehlby C; Sundstroem E; Linnarsson S; Lundeberg J; Nilsson M; Samakovlis C
Article: CELL REPORTS. 2022;38(10):110503
SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells
Hammer Q; Dunst J; Christ W; Picarazzi F; Wendorff M; Momayyezi P; Huhn O; Netskar HK; Maleki KT; Garcia M; Sekine T; Sohlberg E; Azzimato V; Aouadi M; Degenhardt F; Franke A; Spallotta F; Mori M; Michaelsson J; Bjorkstrom NK; Rueckert T; Romagnani C; Horowitz A; Klingstrom J; Ljunggren H-G; Malmberg K-J
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:834862
Comparison of Lung-Homing Receptor Expression and Activation Profiles on NK Cell and T Cell Subsets in COVID-19 and Influenza
Brownlie D; Rodahl I; Varnaite R; Asgeirsson H; Glans H; Falck-Jones S; Vangeti S; Buggert M; Ljunggren H-G; Michaelsson J; Gredmark-Russ S; Smed-Sorensen A; Marquardt N
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(40):e2109123118
High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of in COVID-19
Lourda M; Dzidic M; Hertwig L; Bergsten H; Medina LMP; Sinha I; Kvedaraite E; Chen P; Muvva JR; Gorin J-B; Cornillet M; Emgard J; Moll K; Garcia M; Maleki KT; Klingstrom J; Michaelsson J; Flodstrom-Tullberg M; Brighenti S; Buggert M; Mjosberg J; Malmberg K-J; Sandberg JK; Henter J-I; Folkesson E; Gredmark-Russ S; Sonnerborg A; Eriksson LI; Rooyackers O; Aleman S; Stralin K; Ljunggren H-G; Bjorkstrom NK; Svensson M; Ponzetta A; Norrby-Teglund A; Chambers BJ
Article: CELLS. 2021;10(7):1713
In Vitro Study of Human Immune Responses to Hyaluronic Acid Hydrogels, Recombinant Spidroins and Human Neural Progenitor Cells of Relevance to Spinal Cord Injury Repair
Lin C; Ekblad-Nordberg A; Michaelsson J; Gotherstrom C; Hsu C-C; Ye H; Johansson J; Rising A; Sundstrom E; Akesson E
Article: SCIENCE TRANSLATIONAL MEDICINE. 2021;13(599):eabb3107
A biliary immune landscape map of primary sclerosing cholangitis reveals a dominant network of neutrophils and tissue-resident T cells
Zimmer CL; von Seth E; Buggert M; Strauss O; Hertwig L; Nguyen S; Wong AYW; Zotter C; Berglin L; Michaelsson J; Hansson MR; Arnelo U; Sparrelid E; Ellis ECS; Soderholm JD; Keita AV; Holm K; Ozenci V; Hov JR; Mold JE; Cornillet M; Ponzetta A; Bergquist A; Bjorkstrom NK
Article: CELL REPORTS. 2021;35(8):109174
Divergent clonal differentiation trajectories establish CD8⁺ memory T cell heterogeneity during acute viral infections in humans
Mold JE; Modolo L; Hard J; Zamboni M; Larsson AJM; Stenudd M; Eriksson C-J; Durif G; Stahl PL; Borgstrom E; Picelli S; Reinius B; Sandberg R; Reu P; Talavera-Lopez C; Andersson B; Blom K; Sandberg JK; Picard F; Michaelsson J; Frisen J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(11):e2016580118
Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood
Brownlie D; Scharenberg M; Mold JE; Hard J; Kekalainen E; Buggert M; Nguyen S; Wilson JN; Al-Ameri M; Ljunggren H-G; Marquardt N; Michaelsson J
Article: IMMUNITY. 2021;54(2):259-275.e7
Distinct developmental pathways from blood monocytes generate human lung macrophage diversity
Evren E; Ringqvist E; Tripathi KP; Sleiers N; Rives IC; Alisjahbana A; Gao Y; Sarhan D; Halle T; Sorini C; Lepzien R; Marquardt N; Michaelsson J; Smed-Sorensen A; Botling J; Karlsson MCI; Villablanca EJ; Willinger T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(6):e2018587118
Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity
Kvedaraite E; Hertwig L; Sinha I; Ponzetta A; Myrberg IH; Lourda M; Dzidic M; Akber M; Klingstrom J; Folkesson E; Muvva JR; Chen P; Gredmark-Russ S; Brighenti S; Norrby-Teglund A; Eriksson LI; Rooyackers O; Aleman S; Stralin K; Ljunggren H-G; Ginhoux F; Bjorkstrom NK; Henter J-I; Svensson M
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:752104
CD5 Surface Expression Marks Intravascular Human Innate Lymphoid Cells That Have a Distinct Ontogeny and Migrate to the Lung
Alisjahbana A; Gao Y; Sleiers N; Evren E; Brownlie D; von Kries A; Jorns C; Marquardt N; Michaelsson J; Willinger T
Article: SCIENCE IMMUNOLOGY. 2020;5(50):eabd6832
Natural killer cell immunotypes related to COVID-19 disease severity
Maucourant C; Filipovic I; Ponzetta A; Aleman S; Cornillet M; Hertwig L; Strunz B; Lentini A; Reinius B; Brownlie D; Cuapio A; Ask EH; Hull RM; Haroun-Izquierdo A; Schaffer M; Klingstrom J; Folkesson E; Buggert M; Sandberg JK; Eriksson LI; Rooyackers O; Ljunggren H-G; Malmberg K-J; Michaelsson J; Marquardt N; Hammer Q; Stralin K; Bjorkstrom NK
Article: PLOS BIOLOGY. 2019;17(10):e3000383
Cell generation dynamics underlying naive T-cell homeostasis in adult humans
Mold JE; Reu P; Olin A; Bernard S; Michaelsson J; Rane S; Yates A; Khosravi A; Salehpour M; Possnert G; Brodin P; Frisen J
Article: NATURE COMMUNICATIONS. 2019;10(1):3841
Unique transcriptional and protein-expression signature in human lung tissue-resident NK cells
Marquardt N; Kekalainen E; Chen P; Lourda M; Wilson JN; Scharenberg M; Bergman P; Al-Ameri M; Hard J; Mold JE; Ljunggren H-G; Michaelsson J
Article: GENOME BIOLOGY. 2019;20(1):68
Conbase: a software for unsupervised discovery of clonal somatic mutations in single cells through read phasing
Hard J; Al Hakim E; Kindblom M; Bjorklund AK; Sennblad B; Demirci I; Paterlini M; Reu P; Borgstrom E; Stahl PL; Michaelsson J; Mold JE; Frisen J
Article: JOURNAL OF CROHNS & COLITIS. 2019;13(1):67-78
Distinct Alterations in the Composition of Mucosal Innate Lymphoid Cells in Newly Diagnosed and Established Crohn's Disease and Ulcerative Colitis
Forkel M; van Tol S; Hoog C; Michaelsson J; Almer S; Mjosberg J
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1116
Influenza A Virus Infection Induces Hyperresponsiveness in Human Lung Tissue-Resident and Peripheral Blood NK Cells
Scharenberg M; Vangeti S; Kekalainen E; Bergman P; Al-Ameri M; Johansson N; Sonden K; Falck-Jones S; Farnert A; Ljunggren H-G; Michaelsson J; Smed-Sorensen A; Marquardt N
Article: IMMUNOHORIZONS. 2018;2(6):172-184
Breadth and Dynamics of HLA-A2- and HLA-B7-Restricted CD8+ T Cell Responses against Nonstructural Viral Proteins in Acute Human Tick-Borne Encephalitis Virus Infection.
Lampen MH; Uchtenhagen H; Blom K; Varnaitė R; Pakalniene J; Dailidyte L; Wälchli S; Lindquist L; Mickiene A; Michaëlsson J; Schumacher TN; Ljunggren H-G; Sandberg JK; Achour A; Gredmark-Russ S
Article: BIOINFORMATICS. 2018;34(3):485-493
High dimensional classification with combined adaptive sparse PLS and logistic regression
Durif G; Modolo L; Michaelsson J; Mold JE; Lambert-Lacroix S; Picard F
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2017;47(8):1280-1294
Composition and functionality of the intrahepatic innate lymphoid cell-compartment in human nonfibrotic and fibrotic livers
Forkel M; Berglin L; Kekalainen E; Carlsson A; Svedin E; Michaelsson J; Nagasawa M; Erjefalt JS; Mori M; Flodstrom-Tullberg M; Bergquist A; Ljunggren H-G; Westgren M; Lindforss U; Friberg D; Jorns C; Ellis E; Bjorkstrom NK; Mjosberg J
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(4):1321-1330.e4
Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69^-CD56^dim cells
Marquardt N; Kekalainen E; Chen P; Kvedaraite E; Wilson JN; Ivarsson MA; Mjosberg J; Berglin L; Safholm J; Manson ML; Adner M; Al-Ameri M; Bergman P; Orre A-C; Svensson M; Dahlen B; Dahlen S-E; Ljunggren H-G; Michaelsson J
Article: IMMUNITY. 2017;46(2):287-300
CD49a Expression Defines Tissue-Resident CD8⁺ T Cells Poised for Cytotoxic Function in Human Skin
Cheuk S; Schlums H; Serezal IG; Martini E; Chiang SC; Marquardt N; Gibbs A; Detlofsson E; Introini A; Forkel M; Hoog C; Tjernlund A; Michaelsson J; Folkersen L; Mjosberg J; Blomqvist L; Ehrstrom M; Stahle M; Bryceson YT; Eidsmo L
Article: NATURE GENETICS. 2016;48(11):1430-1435
Analysis of allelic expression patterns in clonal somatic cells by single-cell RNA-seq
Reinius B; Mold JE; Ramskold D; Deng Q; Johnsson P; Michaelsson J; Frisen J; Sandberg R
Article: JOURNAL OF IMMUNOLOGY. 2016;197(8):3069-3075
Fetal CD103⁺ IL-17-Producing Group 3 Innate Lymphoid Cells Represent the Dominant Lymphocyte Subset in Human Amniotic Fluid
Marquardt N; Ivarsson MA; Sundstrom E; Akesson E; Martini E; Eidsmo L; Mjosberg J; Friberg D; Kublickas M; Ek S; Tegerstedt G; Seiger A; Westgren M; Michaelsson J
Article: JOURNAL OF IMMUNOLOGY. 2016;197(7):2762-2771
NK Cell Responses to Human Tick-Borne Encephalitis Virus Infection
Blom K; Braun M; Pakalniene J; Lunemann S; Enqvist M; Dailidyte L; Schaffer M; Lindquist L; Mickiene A; Michaelsson J; Ljunggren H-G; Gredmark-Russ S
Article: JOURNAL OF IMMUNOLOGY. 2015;195(7):3262-3272
The Human NK Cell Response to Yellow Fever Virus 17D Is Primarily Governed by NK Cell Differentiation Independently of NK Cell Education
Marquardt N; Ivarsson MA; Blom K; Gonzalez VD; Braun M; Falconer K; Gustafsson R; Fogdell-Hahn A; Sandberg JK; Michaelsson J
Article: IMMUNITY. 2015;43(2):394-407
Identification of a Human Natural Killer Cell Lineage-Restricted Progenitor in Fetal and Adult Tissues
Renoux VM; Zriwil A; Peitzsch C; Michaelsson J; Friberg D; Soneji S; Sitnicka E
Article: JOURNAL OF IMMUNOLOGY. 2015;194(6):2467-2471
Cutting Edge: Identification and Characterization of Human Intrahepatic CD49a⁺ NK Cells
Marquardt N; Beziat V; Nystrom S; Hengst J; Ivarsson MA; Kekalainen E; Johansson H; Mjosberg J; Westgren M; Lankisch TO; Wedemeyer H; Ellis EC; Ljunggren H-G; Michaelsson J; Bjorkstrom NK
Article: PLOS PATHOGENS. 2015;11(1):e1004622
Specificity and Dynamics of Effector and Memory CD8 T Cell Responses in Human Tick-Borne Encephalitis Virus Infection
Blom K; Braun M; Pakalniene J; Dailidyte L; Beziat V; Lampen MH; Klingstrom J; Lagerqvist N; Kjerstadius T; Michaelsson J; Lindquist L; Ljunggren H-G; Sandberg JK; Mickiene A; Gredmark-Russ S
Article: MUCOSAL IMMUNOLOGY. 2014;7(5):1233-1243
Invariant natural killer T cells developing in the human fetus accumulate and mature in the small intestine
Loh L; Ivarsson MA; Michaelsson J; Sandberg JK; Nixon DF
Article: PLOS PATHOGENS. 2014;10(7):e1004251
T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+T Cells in HIV Infection
Buggert M; Tauriainen J; Yamamoto T; Frederiksen J; Ivarsson MA; Michaelsson J; Lund O; Hejdeman B; Jansson M; Sonnerborg A; Koup RA; Betts MR; Karlsson AC
Article: JOURNAL OF CLINICAL INVESTIGATION. 2013;123(9):3889-3901
Differentiation and functional regulation of human fetal NK cells
Ivarsson MA; Loh L; Marquardt N; Kekalainen E; Berglin L; Bjorkstrom NK; Westgren M; Nixon DF; Michaelsson J
Journal article: JOURNAL OF IMMUNOLOGY. 2013;190(1_Supplement):117.3
Temporal dynamics of the primary human T cell response to yellow fever virus 17D as it matures from an effector- to a memory-type response (P1406)
Blom K; Braun M; Ivarsson M; Gonzalez V; Falconer K; Moll M; Ljunggren H-G; Michaelsson J; Sandberg J
Article: BLOOD. 2013;121(14):2678-2688
NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs
Beziat V; Liu LL; Malmberg J-A; Ivarsson MA; Sohlberg E; Bjorklund AT; Retiere C; Sverremark-Ekstrom E; Traherne J; Ljungman P; Schaffer M; Price DA; Trowsdale J; Michaelsson J; Ljunggren H-G; Malmberg K-J
Article: JOURNAL OF IMMUNOLOGY. 2013;190(5):2150-2158
Temporal Dynamics of the Primary Human T Cell Response to Yellow Fever Virus 17D As It Matures from an Effector- to a Memory-Type Response
Blom K; Braun M; Ivarsson MA; Gonzalez VD; Falconer K; Moll M; Ljunggren H-G; Michaelsson J; Sandberg JK
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2011;41(8):2279-2290
The inflammatory milieu in the rheumatic joint reduces regulatory T-cell function
Herrath J; Muller M; Amoudruz P; Janson P; Michaelsson J; Larsson PT; Trollmo C; Raghavan S; Malmstrom V
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2011;73(2):141-146
NK Cells and CD1d-restricted NKT Cells Respond in Different Ways with Divergent Kinetics to IL-2 Treatment in Primary HIV-1 Infection
Kuylenstierna C; Snyder-Cappione JE; Loo CP; Long BR; Gonzalez VD; Michaelsson J; Moll M; Spotts G; Hecht FM; Nixon DF; Sandberg JK
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2011;208(1):13-21
Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus
Bjorkstrom NK; Lindgren T; Stoltz M; Fauriat C; Braun M; Evander M; Michaelsson J; Malmberg K-J; Klingstrom J; Ahlm C; Ljunggren H-G
Article: SCIENCE. 2010;330(6011):1695-1699
Fetal and Adult Hematopoietic Stem Cells Give Rise to Distinct T Cell Lineages in Humans
Mold JE; Venkatasubrahmanyam S; Burt TD; Michaelsson J; Rivera JM; Galkina SA; Weinberg K; Stoddart CA; McCune JM
Article: BLOOD. 2010;116(19):3853-3864
Expression patterns of NKG2A, KIR, and CD57 define a process of CD56^dim NK-cell differentiation uncoupled from NK-cell education
Bjorkstrom NK; Riese P; Heuts F; Andersson S; Fauriat C; Ivarsson MA; Bjorklund AT; Flodstrom-Tullberg M; Michaelsson J; Rottenberg ME; Guzman CA; Ljunggren H-G; Malmberg K-J
Article: BLOOD. 2010;115(6):1166-1174
Education of human natural killer cells by activating killer cell immunoglobulin-like receptors
Fauriat C; Ivarsson MA; Ljunggren H-G; Malmberg K-J; Michaelsson J
Article: BLOOD. 2009;114(23):4823-4831
Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by coexpression of CD56, CD7, and CD4
Milush JM; Long BR; Snyder-Cappione JE; Cappione AJIII; York VA; Ndhlovu LC; Lanier LL; Michaelsson J; Nixon DF
Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2009;25(6):603-605
HIV-1-Specific T Cell-Dependent Natural Killer (NK) Cell Activation: Major Contribution by NK Cells to Interferon-γ Production in Response to HIV-1 Antigens
Loo CP; Long BR; Hecht FM; Nixon DF; Michaelsson J
Article: SCIENCE. 2008;322(5907):1562-1565
Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero
Mold JE; Michaelsson J; Burt TD; Muench MO; Beckerman KP; Busch MP; Lee T-H; Nixon DF; McCune JM
Article: JOURNAL OF IMMUNOLOGY. 2008;181(9):6010-6019
Estimation of the Size of the Alloreactive NK Cell Repertoire: Studies in Individuals Homozygous for the Group A KIR Haplotype
Fauriat C; Andersson S; Bjorklund AT; Carlsten M; Schaffer M; Bjorkstrom NK; Baumann BC; Michaelsson J; Ljunggren H-G; Malmberg K-J
Article: BMC IMMUNOLOGY. 2008;9:41
The frequency of CD127^low expressing CD4⁺CD25^high T regulatory cells is inversely correlated with human T lymphotrophic virus type-1 (HTLV-1) proviral load in HTLV-1-infection and HTLV-1-associated myelopathy/tropical spastic paraparesis
Michaelsson J; Barbosa HMR; Jordan KA; Chapman JM; Brunialti MKC; Neto WK; Nukui Y; Sabino EC; Chieia MA; Bulle Oiliveira AS; Nixon DF; Kallas EG
Article: CLINICAL IMMUNOLOGY. 2008;128(1):46-56
Expansion of CD56^- NK cells in chronic HCV/HIV-1 co-infection:: Reversion by antiviral treatment with pegylated IFNα and ribavirin
Gonzalez VD; Falconer K; Michaelsson J; Moll M; Reichard O; Alaeus A; Sandberg JK
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2008;330(1-2):64-74
Application of nine-color flow cytometry for detailed studies of the phenotypic complexity and functional heterogeneity of human lymphocyte subsets
Gonzalez VD; Bjorkstroem NK; Malmberg K-J; Moll M; Kuylenstierna C; Michalsson J; Ljunggren H-G; Sandberg JK
Article: JOURNAL OF INFECTIOUS DISEASES. 2008;197(1):117-125
Immune reconstitution of CD56^dim NK cells in individuals with primary HIV-1 infection treated with interleukin-2
Michaelsson J; Long BR; Loo CP; Lanier LL; Spotts G; Hecht FM; Nixon DF
Article: CLINICAL AND VACCINE IMMUNOLOGY. 2008;15(1):120-130
Elevated frequency of gamma interferon-producing NK cells in healthy adults vaccinated against influenza virus
Long BR; Michaelsson J; Loo CP; Ballan WM; Vu B-AN; Hecht FM; Lanier LL; Chapman JM; Nixon DF
Article: IMMUNOLOGY. 2007;122(2):291-301
Activating and inhibitory receptors on synovial fluid natural killer cells of arthritis patients:: role of CD94/NKG2A in control of cytokine secretion
de Matos CT; Berg L; Michaelsson J; Fellander-Tsai L; Kaerre K; Soederstroem K
Article: JOURNAL OF IMMUNOLOGY. 2007;179(5):3362-3370
Natural killer cells in perinatally HIV-1-infected children exhibit less degranulation compared to HIV-1-exposed uninfected children and their expression of KIR2DL3, NKG2C, and NKp46 correlates with disease severity
Ballan WM; Vu B-AN; Long BR; Loo CP; Michaelsson J; Barbour JD; Lanier LL; Wiznia AA; Abadi J; Fennelly GJ; Rosenberg MG; Nixon DF
Article: JOURNAL OF VIROLOGY. 2007;81(11):5759-5765
Human immunodeficiency virus type 1 (HIV-1)-specific CD8⁺ T_EMRA cells in early infection are linked to control of HIV-1 viremia and predict the subsequent viral load set point
Northfield JW; Loo CP; Barbour JD; SpottS G; Hecht FM; Klenerman P; Nixon DF; Michaelsson J
Journal article: JOURNAL OF INFECTION. 2007;54(3):e197
It's not what you've got it's what you do with it: Identifying the components of a Better Immune Response to HIV
Northfield JW; Loo C; Michaelsson J; Nixon D; Klenerman P
Article: JOURNAL OF IMMUNOLOGY. 2007;178(2):647-651
Cutting edge:: KIR3DS1, a gene implicated in resistance to progression to AIDS, encodes a DAP12-associated receptor expressed on NK cells that triggers NK cell activation
Carr WH; Rosen DB; Arase H; Nixon DF; Michaelsson J; Lanier LL
Article: JOURNAL OF IMMUNOLOGY. 2006;176(10):5741-5748
Regulation of T cell responses in the developing human fetus.
Michaëlsson J; Mold JE; McCune JM; Nixon DF
Article: JOURNAL OF MOLECULAR BIOLOGY. 2006;356(2):382-396
Structural basis of the differential stability and receptor specificity of H-2D^b in complex with murine versus human β₂-microglobulin
Achour A; Michaëlsson T; Harris RA; Ljunggren HG; Kärre M; Schneider G; Sandalova T
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2005;61(Pt 12):1090-1093
Expression, refolding and crystallization of murine MHC class IH-2D^b in complex with human β₂-microglobulin
Sandalova T; Michaëlsson J; Harris RA; Ljunggren HG; Kärre K; Schneider G; Achour A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(29):27069-27075
A structural basis for CD8⁺ T cell-dependent recognition of non-homologous peptide ligands -: Implications for molecular mimicry in autoreactivity
Sandalova T; Michaëlsson J; Harris RA; Odeberg J; Schneider G; Kärres K; Achour A
Article: MICROBES AND INFECTION. 2005;7(7-8):1063-1065
CD4+CD25+ regulatory T cells in HIV infection.
Nixon DF; Aandahl EM; Michaëlsson J
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2004;34(6):1646-1653
Loss or mismatch of MHC class I is sufficient to trigger NK cell-mediated rejection of resting lymphocytes in vivo -: role of KARAP/DAP12-dependent and -independent pathways
Öberg L; Johansson S; Michaëlsson J; Tomasello E; Vivier E; Kärre K; Höglund P
Article: JOURNAL OF IMMUNOLOGY. 2004;172(9):5504-5511
Determination of structural principles underlying three different modes of lymphocytic choriomeningitis virus escape from CTL recognition
Velloso LM; Michaëlsson J; Ljunggren HG; Schneider G; Achour A
Article: JOURNAL OF VIROLOGY. 2004;78(5):2454-2459
Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens.
Aandahl EM; Michaëlsson J; Moretto WJ; Hecht FM; Nixon DF
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2003;33(10):2727-2735
Regulation of perforin-independent NK cell-mediated cytotoxicity
Wallin RPA; Screpanti V; Michaëlsson J; Grandien A; Ljunggren HG
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2002;196(11):1403-1414
A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition
Michaëlsson J; de Matos CT; Achour A; Lanier LL; Kärre K; Söderström K
Article: IMMUNITY. 2002;17(6):757-768
A structural basis for LCMV immune evasion:: Subversion of H-2D^b and H-2K^b presentation of gp33 revealed by comparative crystal structure analyses
Achour A; Michaëlsson J; Harris RA; Odeberg J; Grufman P; Sandberg JK; Levitsky V; Kärre K; Sandalova T; Schneider G
Article: CANCER RESEARCH. 2002;62(4):1116-1122
Apoptosis-dependent subversion of the T-lymphocyte epitope hierarchy in lymphoma cells
Castiglioni P; Martin-Fontecha A; Milan G; Tomajer V; Magni F; Michaelsson J; Rugarli C; Rosato A; Bellone M
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2002;55(2):129-139
The role of an exposed loop in the α₂ domain in the mouse MHC class IH-2D_d molecule for recognition by the monoclonal antibody 34-5-8S and the NK-cell receptor Ly49A
Waldenström M; Achour A; Michaelsson J; Rölle A; Kärre K
Article: JOURNAL OF IMMUNOLOGY. 2002;168(2):793-800
NK cell inhibitory receptor Ly-49C residues involved in MHC class I binding
Sundbäck J; Achour A; Michaëlsson J; Lindström H; Kärre K
Article: JOURNAL OF IMMUNOLOGY. 2001;166(12):7327-7334
MHC class I recognition by NK receptors in the Ly49 family is strongly influenced by the β₂-microglobulin subunit
Michaëlsson J; Achour A; Rölle A; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2001;31(3):869-875
Purified MHC class I molecules inhibit activated NK cells in a cell-free system in vitro
Kambayashi T; Michaëlsson J; Fahlén L; Chambers BJ; Sentman CL; Kärre K; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 2000;165(9):4964-4969
Emergence of CD8⁺ T cells expressing NK cell receptors in influenza A virus-infected mice
Kambayashi T; Assarsson E; Michaëlsson J; Berglund P; Diehl AP; Chambers BJ; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 2000;165(1):25-33
T cell tolerance based on avidity thresholds rather than complete deletion allows maintenance of maximal repertoire diversity
Sandberg JK; Franksson L; Sundbäck J; Michaelsson J; Petersson M; Achour A; Wallin RPA; Sherman NE; Bergman T; Jörnvall H; Hunt DF; Kiessling R; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2000;30(1):300-307
Visualization of inhibitory Ly49 receptor specificity with soluble major histocompatibility complex class I tetramers
Michaëlsson J; Achour A; Salcedo M; Kåse-Sjöström A; Sundbäck J; Harris RA; Kärre K
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Preprint: BIORXIV. 2025
Cell lineage inference from mitochondrial mutations
Hård J; Seidel S; Ferreira PF; Berkes P; Jahn K; Eriksson C-J; Mold JE; Michaelsson J; Kuipers J; Beerenwinkel N
Book chapter: NATURAL KILLER CELLS. 2025;p. 1-23
Natural Killer Cells in the Human Lung
Marquardt N; Ljunggren H-G; Michaëlsson J
Review: FRONTIERS IN IMMUNOLOGY. 2018;9:2174
Cell-Mediated Immune Responses and Immunopathogenesis of Human Tick-Borne Encephalitis Virus-Infection
Blom K; Cuapio A; Sandberg JT; Varnaite R; Michaelsson J; Bjorkstrom NK; Sandberg JK; Klingstrom J; Lindquist L; Russ SG; Ljunggren H-G
Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;140(1):318
Polyfunctionality of bona fide resident lung CD69⁺ natural killer cells Reply
Marquardt N; Ljunggren H-G; Michaelsson J
Review: NATURE REVIEWS IMMUNOLOGY. 2016;16(5):310-320
Emerging insights into natural killer cells in human peripheral tissues
Bjorkstrom NK; Ljunggren H-G; Michaelsson J
Editorial comment: EUROPEAN JOURNAL OF IMMUNOLOGY. 2014;44(7):2192-2196
Tracing dynamic expansion of human NK-cell subsets by high-resolution analysis of KIR repertoires and cellular differentiation
Beziat V; Traherne J; Malmberg J-A; Ivarsson MA; Bjorkstrom NK; Retiere C; Ljunggren H-G; Michaelsson J; Trowsdale J; Malmberg K-J
Review: FRONTIERS IN IMMUNOLOGY. 2014;5:184-9
Activating killer cell Ig-like receptors In health and disease
Ivarsson MA; Michaelsson J; Fauriat C
Other: IMMUNITY. 2011;35(5):653-657
Killer Cell Immunoglobulin-like Receptor Workshop: Insights into Evolution, Genetics, Function, and Translation
Malmberg K-J; Michaelsson J; Parham P; Ljunggren H-G
Meeting abstract: RETROVIROLOGY. 2009;6:p23
Preserved cellular and humoral immune responses in macaques infected with SIVmac239 and subjected to early antiretroviral therapy
Makitalo B; Walther-Jallow L; Sahin GO; Michaelsson J; Spangberg M; Thorstensson R; Fenyo E; Spetz A
Doctoral thesis: 2002
Decoding NK cell receptor specificity : functional and structural studies of MHC class 1 subcomponents
Michaëlsson J

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Medfödda lymfoida cellers utveckling och differentiering på klonal nivå
Vetenskapsrådet
1 January 2025 - 31 December 2028
Cancerfonden

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Senior Forskare, Medicin, Huddinge, Karolinska Institutet, 2022-

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Docent, Immunologi, Karolinska Institutet, 2015
MEDICINE DOKTORSEXAMEN, Institutionen för mikrobiologi, tumör- och cellbiologi, Karolinska Institutet, 2002

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