Jakob Michaelsson
About me
Jakob Michaëlsson is the group leader of the Michaelsson research group at the at the Center for Infectious Medicine (CIM) at the Department of Medicine Huddinge. He received his PhD at Karolinska Institutet in 2002 studying Natural Killer (NK) cell biology and after a postdoc at the University of California San Francisco where he continued his research in human immunology he has been a group leader at CIM since 2008. His research includes studies of human immune cell development, immune regulation and immune responses to cancer, with a particular focus on NK cells, ILCs, and CD8+ T cells.
Research
The main focus of our research is to understand how human Natural Killer (NK) cells, ILCs, and CD8 T cells develop and function during different stages of life, in different tissues, and during different conditions. The longterm goal with our research is to aid in the development of new therapies in cancer and infectious diseases. We have a strong competence in advanced flow cytometry analysis of human immune cells in blood and tissues, paired with RNA sequencing and functional in vitro assays.
Development of human innate lymphoid cells in fetal tissuesLittle is known about how and where human immune cells develop and mature, and what signals are regulating innate lymphoid cell (ILC) development, including NK cells. We have previously investigated the development and function of fetal NK cells and T cells in the developing fetus, demonstrating that they are phenotypically and functionally distinct from those in adults. Within this project we are currently aiming at elucidating the developmental trajectories of human fetal ILCs from precursor stages to mature cells, and to investigate how fetal ILCs compare to adult ILCs in various human tissues.
Tissue-resident NK cells in the human lung and lung tumors
We believe that this project will provide important knowledge regarding the development of the human immune system, which could have implications in for example in utero therapies and for our understanding of immune responses in new born babies.Most of our knowledge regarding human NK cell biology is based on studies of these cells in peripheral blood. Recently it has becoming increasingly clear that NK cells in tissues differ from those in tissues, with distinct phenotypes, function and possibly developmental origins. In this project we focus on the biology of tissue-resident NK cells in the human lung and what role they might play lung tumors. The project is a collaboration with
Team Marquardt at The Center for Hematology and Regenerative Medicine (HERM) in Neo.
Formation of the human memory CD8+ T cell repertoire at the clonal levelCD8+ T cells play an important role in our defense against viral infections and tumors. It is well known that antigen-specific CD8+ T cells expand in viral infections and eventually form a broad repertoire of memory CD8+ T cells that can help in protecting against subsequent infections with the same virus. In this project we collaborate with Dr Jeff Mold and the Frisén lab to investigate how the repertoire of memory CD8+ T cells is shaped by distinct clonal identities over time in response to vaccination against Yellow Fever virus.
Articles
- Article: SCIENCE IMMUNOLOGY. 2025;10(109):eadq4881Niessl J; Mueller TR; Constantz C; Cai C; Nilsen V; Ballesteros OR; Adamo S; Kammann T; Mouchtaridi E; Gao Y; Akhirunnesa M; Raineri EJM; Weigel W; Kokkinou E; Stamper C; Marchalot A; Bassett J; Ferreira S; Rodahl I; Wild N; Stellaccio T; Brownlie D; Ringqvist E; Flodstrom-Tullberg M; Llewellyn-Lacey S; Tibbitt C; Hammer Q; Michaelsson J; Price DA; Mjosberg J; Marquardt N; Sandberg JK; Sekine T; Jorns C; Buggert M
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2025;122(6):e2414230122Boulouis C; Mouchtaridi E; Muller TR; Mak JYW; Fairlie DP; Bergman P; Michaelsson J; Halfvarson J; Mjosberg J; Buggert M; Sandberg JK
- Article: GENES AND IMMUNITY. 2025;26(1):70-74Strunz B; Momayyezi P; Bilev E; Muvva JR; Chen P; Bister J; Schaffer M; Akber M; Cornillet M; Horowitz A; Malmberg K-J; Rooyackers O; Aleman S; Ljunggren H-G; Bjorkstrom NK; Stralin K; Hammer Q
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2025;55(2):e202451150Rodahl IE; Ivarsson MA; Loh L; Mold JE; Westgren M; Friberg D; Mjosberg J; Bjorkstrom NK; Marquardt N; Nixon DF; Michaelsson J
- Article: PLOS NEGLECTED TROPICAL DISEASES. 2025;19(2):e0012693Wullimann D; Sandberg JT; Akber M; Lofling M; Gredmark-Russ S; Michaelsson J; Buggert M; Blom K; Ljunggren H-G
- Article: SCIENCE IMMUNOLOGY. 2024;9(99):eadn2362Kammann T; Cai C; Sekine T; Mouchtaridi E; Boulouis C; Nilsen V; Ballesteros OR; Mueller TR; Gao Y; Raineri EJM; Mily A; Adamo S; Constantz C; Niessl J; Weigel W; Kokkinou E; Stamper C; Marchalot A; Bassett J; Ferreira S; Rodahl I; Wild N; Brownlie D; Tibbitt C; Mak JYW; Fairlie DP; Leeansyah E; Michaelsson J; Marquardt N; Mjosberg J; Jorns C; Buggert M; Sandberg JK
- Article: NATURE IMMUNOLOGY. 2024;25(8):1445-1459Netskar H; Pfefferle A; Goodridge JP; Sohlberg E; Dufva O; Teichmann SA; Brownlie D; Michaelsson J; Marquardt N; Clancy T; Horowitz A; Malmberg K-J
- Article: SCIENCE IMMUNOLOGY. 2024;9(94):eadj7168Bister J; Filipovic I; Sun D; Crona-Guterstam Y; Cornillet M; Ponzetta A; Michaelsson J; Gidloef S; Ivarsson MA; Strunz B; Bjoerkstroem NK
- Article: CELL SYSTEMS. 2024;15(2):149-165.e10Mold JE; Weissman MH; Ratz M; Hagemann-Jensen M; Hard J; Eriksson C-J; Toosi H; Berghenstrahle J; Ziegenhain C; von Berlin L; Martin M; Blom K; Lagergren J; Lundeberg J; Sandberg R; Michaeeurolsson J; Frisen J
- Article: ONCOIMMUNOLOGY. 2023;12(1):2233402Brownlie D; von Kries A; Valenzano G; Wild N; Yilmaz E; Safholm J; Al-Ameri M; Alici E; Ljunggren H-G; Schliemann I; Aricak O; de Flon FH; Michaelsson J; Marquardt N
- Article: SCIENCE. 2023;382(6675):eadf8486Engblom C; Thrane K; Lin Q; Andersson A; Toosi H; Chen X; Steiner E; Lu C; Mantovani G; Hagemann-Jensen M; Saarenpaa S; Jangard M; Saez-Rodriguez J; Michaelsson J; Hartman J; Lagergren J; Mold JE; Lundeberg J; Frisen J
- Article: NATURE COMMUNICATIONS. 2023;14(1):5164Hard J; Mold JE; Eisfeldt J; Tellgren-Roth C; Haggqvist S; Bunikis I; Contreras-Lopez O; Chin C-S; Nordlund J; Rubin C-J; Feuk L; Michaelsson J; Ameur A
- Article: RESPIRATORY RESEARCH. 2023;24(1):62Palma Medina LM; Babacic H; Dzidic M; Parke A; Garcia M; Maleki KT; Unge C; Lourda M; Kvedaraite E; Chen P; Muvva JR; Cornillet M; Emgard J; Moll K; Michaelsson J; Flodstrom-Tullberg M; Brighenti S; Buggert M; Mjosberg J; Malmberg K-JK; Sandberg J; Gredmark-Russ S; Rooyackers O; Svensson MJ; Chambers BI; Eriksson L; Pernemalm MK; Bjorkstrom N; Aleman S; Ljunggren H-G; Klingstrom J; Stralin K; Norrby-Teglund A
- Article: NATURE CELL BIOLOGY. 2023;25(2):351-365Sountoulidis A; Marco Salas S; Braun E; Avenel C; Bergenstrahle J; Theelke J; Vicari M; Czarnewski P; Liontos A; Abalo X; Andrusivova Z; Mirzazadeh R; Asp M; Li X; Hu L; Sariyar S; Martinez Casals A; Ayoglu B; Firsova A; Michaelsson J; Lundberg E; Waehlby C; Sundstroem E; Linnarsson S; Lundeberg J; Nilsson M; Samakovlis C
- Article: FRONTIERS IN IMMUNOLOGY. 2022;13:834862Brownlie D; Rodahl I; Varnaite R; Asgeirsson H; Glans H; Falck-Jones S; Vangeti S; Buggert M; Ljunggren H-G; Michaelsson J; Gredmark-Russ S; Smed-Sorensen A; Marquardt N
- Article: CELL REPORTS. 2022;38(10):110503Hammer Q; Dunst J; Christ W; Picarazzi F; Wendorff M; Momayyezi P; Huhn O; Netskar HK; Maleki KT; Garcia M; Sekine T; Sohlberg E; Azzimato V; Aouadi M; Degenhardt F; Franke A; Spallotta F; Mori M; Michaelsson J; Bjorkstrom NK; Rueckert T; Romagnani C; Horowitz A; Klingstrom J; Ljunggren H-G; Malmberg K-J
- Article: FRONTIERS IN IMMUNOLOGY. 2021;12:752104Alisjahbana A; Gao Y; Sleiers N; Evren E; Brownlie D; von Kries A; Jorns C; Marquardt N; Michaelsson J; Willinger T
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(40):e2109123118Lourda M; Dzidic M; Hertwig L; Bergsten H; Medina LMP; Sinha I; Kvedaraite E; Chen P; Muvva JR; Gorin J-B; Cornillet M; Emgard J; Moll K; Garcia M; Maleki KT; Klingstrom J; Michaelsson J; Flodstrom-Tullberg M; Brighenti S; Buggert M; Mjosberg J; Malmberg K-J; Sandberg JK; Henter J-I; Folkesson E; Gredmark-Russ S; Sonnerborg A; Eriksson LI; Rooyackers O; Aleman S; Stralin K; Ljunggren H-G; Bjorkstrom NK; Svensson M; Ponzetta A; Norrby-Teglund A; Chambers BJ
- Article: CELLS. 2021;10(7):1713Lin C; Ekblad-Nordberg A; Michaelsson J; Gotherstrom C; Hsu C-C; Ye H; Johansson J; Rising A; Sundstrom E; Akesson E
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2021;13(599):eabb3107Zimmer CL; von Seth E; Buggert M; Strauss O; Hertwig L; Nguyen S; Wong AYW; Zotter C; Berglin L; Michaelsson J; Hansson MR; Arnelo U; Sparrelid E; Ellis ECS; Soderholm JD; Keita AV; Holm K; Ozenci V; Hov JR; Mold JE; Cornillet M; Ponzetta A; Bergquist A; Bjorkstrom NK
- Article: CELL REPORTS. 2021;35(8):109174Mold JE; Modolo L; Hard J; Zamboni M; Larsson AJM; Stenudd M; Eriksson C-J; Durif G; Stahl PL; Borgstrom E; Picelli S; Reinius B; Sandberg R; Reu P; Talavera-Lopez C; Andersson B; Blom K; Sandberg JK; Picard F; Michaelsson J; Frisen J
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(11):e2016580118Brownlie D; Scharenberg M; Mold JE; Hard J; Kekalainen E; Buggert M; Nguyen S; Wilson JN; Al-Ameri M; Ljunggren H-G; Marquardt N; Michaelsson J
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(6):e2018587118Kvedaraite E; Hertwig L; Sinha I; Ponzetta A; Myrberg IH; Lourda M; Dzidic M; Akber M; Klingstrom J; Folkesson E; Muvva JR; Chen P; Gredmark-Russ S; Brighenti S; Norrby-Teglund A; Eriksson LI; Rooyackers O; Aleman S; Stralin K; Ljunggren H-G; Ginhoux F; Bjorkstrom NK; Henter J-I; Svensson M
- Article: IMMUNITY. 2021;54(2):259-275.e7Evren E; Ringqvist E; Tripathi KP; Sleiers N; Rives IC; Alisjahbana A; Gao Y; Sarhan D; Halle T; Sorini C; Lepzien R; Marquardt N; Michaelsson J; Smed-Sorensen A; Botling J; Karlsson MCI; Villablanca EJ; Willinger T
- Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1306Sandberg JT; Varnaite R; Christ W; Chen P; Muvva JR; Maleki KT; Garcia M; Dzidic M; Folkesson E; Skagerberg M; Ahlen G; Frelin L; Sallberg M; Eriksson LI; Rooyackers O; Sonnerborg A; Buggert M; Bjorkstrom NK; Aleman S; Stralin K; Klingstrom J; Ljunggren H-G; Blom K; Gredmark-Russ S
- Article: CELL. 2020;183(1):158-168.e14Sekine T; Perez-Potti A; Rivera-Ballesteros O; Stralin K; Gorin J-B; Olsson A; Llewellyn-Lacey S; Kamal H; Bogdanovic G; Muschiol S; Wullimann DJ; Kammann T; Emgard J; Parrot T; Folkesson E; Rooyackers O; Eriksson LI; Henter J-I; Sonnerborg A; Allander T; Albert J; Nielsen M; Klingstrom J; Gredmark-Russ S; Bjorkstrom NK; Sandberg JK; Price DA; Ljunggren H-G; Aleman S; Buggert M
- Article: SCIENCE IMMUNOLOGY. 2020;5(51):eabe1670Parrot T; Gorin J-B; Ponzetta A; Maleki KT; Kammann T; Emgard J; Perez-Potti A; Sekine T; Rivera-Ballesteros O; Gredmark-Russ S; Rooyackers O; Folkesson E; Eriksson LI; Norrby-Teglund A; Ljunggren H-G; Bjorkstrom NK; Aleman S; Buggert M; Klingstrom J; Stralin K; Sandberg JK
- Article: SCIENCE IMMUNOLOGY. 2020;5(50):eabd6832Maucourant C; Filipovic I; Ponzetta A; Aleman S; Cornillet M; Hertwig L; Strunz B; Lentini A; Reinius B; Brownlie D; Cuapio A; Ask EH; Hull RM; Haroun-Izquierdo A; Schaffer M; Klingstrom J; Folkesson E; Buggert M; Sandberg JK; Eriksson LI; Rooyackers O; Ljunggren H-G; Malmberg K-J; Michaelsson J; Marquardt N; Hammer Q; Stralin K; Bjorkstrom NK
- Article: PLOS BIOLOGY. 2019;17(10):e3000383Mold JE; Reu P; Olin A; Bernard S; Michaelsson J; Rane S; Yates A; Khosravi A; Salehpour M; Possnert G; Brodin P; Frisen J
- Article: NATURE COMMUNICATIONS. 2019;10(1):3841Marquardt N; Kekalainen E; Chen P; Lourda M; Wilson JN; Scharenberg M; Bergman P; Al-Ameri M; Hard J; Mold JE; Ljunggren H-G; Michaelsson J
- Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1116Scharenberg M; Vangeti S; Kekalainen E; Bergman P; Al-Ameri M; Johansson N; Sonden K; Falck-Jones S; Farnert A; Ljunggren H-G; Michaelsson J; Smed-Sorensen A; Marquardt N
- Article: GENOME BIOLOGY. 2019;20(1):68Hard J; Al Hakim E; Kindblom M; Bjorklund AK; Sennblad B; Demirci I; Paterlini M; Reu P; Borgstrom E; Stahl PL; Michaelsson J; Mold JE; Frisen J
- Article: JOURNAL OF CROHNS & COLITIS. 2019;13(1):67-78Forkel M; van Tol S; Hoog C; Michaelsson J; Almer S; Mjosberg J
- Article: IMMUNOHORIZONS. 2018;2(6):172-184Lampen MH; Uchtenhagen H; Blom K; Varnaitė R; Pakalniene J; Dailidyte L; Wälchli S; Lindquist L; Mickiene A; Michaëlsson J; Schumacher TN; Ljunggren H-G; Sandberg JK; Achour A; Gredmark-Russ S
- Article: BIOINFORMATICS. 2018;34(3):485-493Durif G; Modolo L; Michaelsson J; Mold JE; Lambert-Lacroix S; Picard F
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2017;47(8):1280-1294Forkel M; Berglin L; Kekalainen E; Carlsson A; Svedin E; Michaelsson J; Nagasawa M; Erjefalt JS; Mori M; Flodstrom-Tullberg M; Bergquist A; Ljunggren H-G; Westgren M; Lindforss U; Friberg D; Jorns C; Ellis E; Bjorkstrom NK; Mjosberg J
- Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;140(1):318Marquardt N; Ljunggren H-G; Michaelsson J
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(4):1321-1330.e4Marquardt N; Kekalainen E; Chen P; Kvedaraite E; Wilson JN; Ivarsson MA; Mjosberg J; Berglin L; Safholm J; Manson ML; Adner M; Al-Ameri M; Bergman P; Orre A-C; Svensson M; Dahlen B; Dahlen S-E; Ljunggren H-G; Michaelsson J
- Article: IMMUNITY. 2017;46(2):287-300Cheuk S; Schlums H; Serezal IG; Martini E; Chiang SC; Marquardt N; Gibbs A; Detlofsson E; Introini A; Forkel M; Hoog C; Tjernlund A; Michaelsson J; Folkersen L; Mjosberg J; Blomqvist L; Ehrstrom M; Stahle M; Bryceson YT; Eidsmo L
- Article: NATURE GENETICS. 2016;48(11):1430-1435Reinius B; Mold JE; Ramskold D; Deng Q; Johnsson P; Michaelsson J; Frisen J; Sandberg R
- Article: JOURNAL OF IMMUNOLOGY. 2016;197(8):3069-3075Marquardt N; Ivarsson MA; Sundstrom E; Akesson E; Martini E; Eidsmo L; Mjosberg J; Friberg D; Kublickas M; Ek S; Tegerstedt G; Seiger A; Westgren M; Michaelsson J
- Article: JOURNAL OF IMMUNOLOGY. 2016;197(7):2762-2771Blom K; Braun M; Pakalniene J; Lunemann S; Enqvist M; Dailidyte L; Schaffer M; Lindquist L; Mickiene A; Michaelsson J; Ljunggren H-G; Gredmark-Russ S
- Article: JOURNAL OF IMMUNOLOGY. 2015;195(7):3262-3272Marquardt N; Ivarsson MA; Blom K; Gonzalez VD; Braun M; Falconer K; Gustafsson R; Fogdell-Hahn A; Sandberg JK; Michaelsson J
- Article: IMMUNITY. 2015;43(2):394-407Renoux VM; Zriwil A; Peitzsch C; Michaelsson J; Friberg D; Soneji S; Sitnicka E
- Article: JOURNAL OF IMMUNOLOGY. 2015;194(6):2467-2471Marquardt N; Beziat V; Nystrom S; Hengst J; Ivarsson MA; Kekalainen E; Johansson H; Mjosberg J; Westgren M; Lankisch TO; Wedemeyer H; Ellis EC; Ljunggren H-G; Michaelsson J; Bjorkstrom NK
- Article: PLOS PATHOGENS. 2015;11(1):e1004622Blom K; Braun M; Pakalniene J; Dailidyte L; Beziat V; Lampen MH; Klingstrom J; Lagerqvist N; Kjerstadius T; Michaelsson J; Lindquist L; Ljunggren H-G; Sandberg JK; Mickiene A; Gredmark-Russ S
- Article: MUCOSAL IMMUNOLOGY. 2014;7(5):1233-1243Loh L; Ivarsson MA; Michaelsson J; Sandberg JK; Nixon DF
- Journal article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2014;44(7):2192-2196Beziat V; Traherne J; Malmberg J-A; Ivarsson MA; Bjorkstrom NK; Retiere C; Ljunggren H-G; Michaelsson J; Trowsdale J; Malmberg K-J
- Article: PLOS PATHOGENS. 2014;10(7):e1004251T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+T Cells in HIV InfectionBuggert M; Tauriainen J; Yamamoto T; Frederiksen J; Ivarsson MA; Michaelsson J; Lund O; Hejdeman B; Jansson M; Sonnerborg A; Koup RA; Betts MR; Karlsson AC
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2013;123(9):3889-3901Ivarsson MA; Loh L; Marquardt N; Kekalainen E; Berglin L; Bjorkstrom NK; Westgren M; Nixon DF; Michaelsson J
- Journal article: JOURNAL OF IMMUNOLOGY. 2013;190(Supplement_1):117.3Blom K; Braun M; Ivarsson M; Gonzalez V; Falconer K; Moll M; Ljunggren H-G; Michaelsson J; Sandberg J
- Article: BLOOD. 2013;121(14):2678-2688Beziat V; Liu LL; Malmberg J-A; Ivarsson MA; Sohlberg E; Bjorklund AT; Retiere C; Sverremark-Ekstrom E; Traherne J; Ljungman P; Schaffer M; Price DA; Trowsdale J; Michaelsson J; Ljunggren H-G; Malmberg K-J
- Article: JOURNAL OF IMMUNOLOGY. 2013;190(5):2150-2158Blom K; Braun M; Ivarsson MA; Gonzalez VD; Falconer K; Moll M; Ljunggren H-G; Michaelsson J; Sandberg JK
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2011;41(8):2279-2290Herrath J; Muller M; Amoudruz P; Janson P; Michaelsson J; Larsson PT; Trollmo C; Raghavan S; Malmstrom V
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2011;73(2):141-146Kuylenstierna C; Snyder-Cappione JE; Loo CP; Long BR; Gonzalez VD; Michaelsson J; Moll M; Spotts G; Hecht FM; Nixon DF; Sandberg JK
- Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2011;208(1):13-21Bjorkstrom NK; Lindgren T; Stoltz M; Fauriat C; Braun M; Evander M; Michaelsson J; Malmberg K-J; Klingstrom J; Ahlm C; Ljunggren H-G
- Article: SCIENCE. 2010;330(6011):1695-1699Mold JE; Venkatasubrahmanyam S; Burt TD; Michaelsson J; Rivera JM; Galkina SA; Weinberg K; Stoddart CA; McCune JM
- Article: BLOOD. 2010;116(19):3853-3864Bjorkstrom NK; Riese P; Heuts F; Andersson S; Fauriat C; Ivarsson MA; Bjorklund AT; Flodstrom-Tullberg M; Michaelsson J; Rottenberg ME; Guzman CA; Ljunggren H-G; Malmberg K-J
- Article: BLOOD. 2010;115(6):1166-1174Fauriat C; Ivarsson MA; Ljunggren H-G; Malmberg K-J; Michaelsson J
- Article: BLOOD. 2009;114(23):4823-4831Milush JM; Long BR; Snyder-Cappione JE; Cappione AJIII; York VA; Ndhlovu LC; Lanier LL; Michaelsson J; Nixon DF
- Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2009;25(6):603-605Loo CP; Long BR; Hecht FM; Nixon DF; Michaelsson J
- Article: SCIENCE. 2008;322(5907):1562-1565Mold JE; Michaelsson J; Burt TD; Muench MO; Beckerman KP; Busch MP; Lee T-H; Nixon DF; McCune JM
- Article: JOURNAL OF IMMUNOLOGY. 2008;181(9):6010-6019Fauriat C; Andersson S; Bjorklund AT; Carlsten M; Schaffer M; Bjorkstrom NK; Baumann BC; Michaelsson J; Ljunggren H-G; Malmberg K-J
- Article: BMC IMMUNOLOGY. 2008;9:41Michaelsson J; Barbosa HMR; Jordan KA; Chapman JM; Brunialti MKC; Neto WK; Nukui Y; Sabino EC; Chieia MA; Bulle Oiliveira AS; Nixon DF; Kallas EG
- Article: CLINICAL IMMUNOLOGY. 2008;128(1):46-56Gonzalez VD; Falconer K; Michaelsson J; Moll M; Reichard O; Alaeus A; Sandberg JK
- Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2008;330(1-2):64-74Gonzalez VD; Bjorkstroem NK; Malmberg K-J; Moll M; Kuylenstierna C; Michalsson J; Ljunggren H-G; Sandberg JK
- Article: JOURNAL OF INFECTIOUS DISEASES. 2008;197(1):117-125Michaelsson J; Long BR; Loo CP; Lanier LL; Spotts G; Hecht FM; Nixon DF
- Article: CLINICAL AND VACCINE IMMUNOLOGY. 2008;15(1):120-130Long BR; Michaelsson J; Loo CP; Ballan WM; Vu B-AN; Hecht FM; Lanier LL; Chapman JM; Nixon DF
- Article: IMMUNOLOGY. 2007;122(2):291-301de Matos CT; Berg L; Michaelsson J; Fellander-Tsai L; Kaerre K; Soederstroem K
- Article: JOURNAL OF IMMUNOLOGY. 2007;179(5):3362-3370Ballan WM; Vu B-AN; Long BR; Loo CP; Michaelsson J; Barbour JD; Lanier LL; Wiznia AA; Abadi J; Fennelly GJ; Rosenberg MG; Nixon DF
- Article: JOURNAL OF VIROLOGY. 2007;81(11):5759-5765Northfield JW; Loo CP; Barbour JD; SpottS G; Hecht FM; Klenerman P; Nixon DF; Michaelsson J
- Journal article: JOURNAL OF INFECTION. 2007;54(3):e197Northfield JW; Loo C; Michaelsson J; Nixon D; Klenerman P
- Article: JOURNAL OF IMMUNOLOGY. 2007;178(2):647-651Carr WH; Rosen DB; Arase H; Nixon DF; Michaelsson J; Lanier LL
- Article: JOURNAL OF IMMUNOLOGY. 2006;176(10):5741-5748Michaëlsson J; Mold JE; McCune JM; Nixon DF
- Article: JOURNAL OF MOLECULAR BIOLOGY. 2006;356(2):382-396Achour A; Michaëlsson T; Harris RA; Ljunggren HG; Kärre M; Schneider G; Sandalova T
- Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2005;61(Pt 12):1090-1093Sandalova T; Michaëlsson J; Harris RA; Ljunggren HG; Kärre K; Schneider G; Achour A
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(29):27069-27075Sandalova T; Michaëlsson J; Harris RA; Odeberg J; Schneider G; Kärres K; Achour A
- Article: MICROBES AND INFECTION. 2005;7(7-8):1063-1065Nixon DF; Aandahl EM; Michaëlsson J
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2004;34(6):1646-1653Öberg L; Johansson S; Michaëlsson J; Tomasello E; Vivier E; Kärre K; Höglund P
- Article: JOURNAL OF IMMUNOLOGY. 2004;172(9):5504-5511Velloso LM; Michaëlsson J; Ljunggren HG; Schneider G; Achour A
- Article: JOURNAL OF VIROLOGY. 2004;78(5):2454-2459Aandahl EM; Michaëlsson J; Moretto WJ; Hecht FM; Nixon DF
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2003;33(10):2727-2735Wallin RPA; Screpanti V; Michaëlsson J; Grandien A; Ljunggren HG
- Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2002;196(11):1403-1414Michaëlsson J; de Matos CT; Achour A; Lanier LL; Kärre K; Söderström K
- Article: IMMUNITY. 2002;17(6):757-768Achour A; Michaëlsson J; Harris RA; Odeberg J; Grufman P; Sandberg JK; Levitsky V; Kärre K; Sandalova T; Schneider G
- Article: CANCER RESEARCH. 2002;62(4):1116-1122Castiglioni P; Martin-Fontecha A; Milan G; Tomajer V; Magni F; Michaelsson J; Rugarli C; Rosato A; Bellone M
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2002;55(2):129-139Waldenström M; Achour A; Michaelsson J; Rölle A; Kärre K
- Article: JOURNAL OF IMMUNOLOGY. 2002;168(2):793-800Sundbäck J; Achour A; Michaëlsson J; Lindström H; Kärre K
- Article: JOURNAL OF IMMUNOLOGY. 2001;166(12):7327-7334Michaëlsson J; Achour A; Rölle A; Kärre K
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2001;31(3):869-875Kambayashi T; Michaëlsson J; Fahlén L; Chambers BJ; Sentman CL; Kärre K; Ljunggren HG
- Article: JOURNAL OF IMMUNOLOGY. 2000;165(9):4964-4969Kambayashi T; Assarsson E; Michaëlsson J; Berglund P; Diehl AP; Chambers BJ; Ljunggren HG
- Article: JOURNAL OF IMMUNOLOGY. 2000;165(1):25-33Sandberg JK; Franksson L; Sundbäck J; Michaelsson J; Petersson M; Achour A; Wallin RPA; Sherman NE; Bergman T; Jörnvall H; Hunt DF; Kiessling R; Kärre K
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2000;30(1):300-307Michaëlsson J; Achour A; Salcedo M; Kåse-Sjöström A; Sundbäck J; Harris RA; Kärre K
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All other publications
- Preprint: BIORXIV. 2025Hård J; Seidel S; Ferreira PF; Berkes P; Jahn K; Eriksson C-J; Mold JE; Michaelsson J; Kuipers J; Beerenwinkel N
- Book chapter: NATURAL KILLER CELLS. 2025;p. 1-23Marquardt N; Ljunggren H-G; Michaëlsson J
- Review: FRONTIERS IN IMMUNOLOGY. 2018;9:2174Blom K; Cuapio A; Sandberg JT; Varnaite R; Michaelsson J; Bjorkstrom NK; Sandberg JK; Klingstrom J; Lindquist L; Russ SG; Ljunggren H-G
- Review: NATURE REVIEWS IMMUNOLOGY. 2016;16(5):310-320Bjorkstrom NK; Ljunggren H-G; Michaelsson J
- Review: FRONTIERS IN IMMUNOLOGY. 2014;5:184-9Ivarsson MA; Michaelsson J; Fauriat C
- Other: IMMUNITY. 2011;35(5):653-657Malmberg K-J; Michaelsson J; Parham P; Ljunggren H-G
- Meeting abstract: RETROVIROLOGY. 2009;6:p23Makitalo B; Walther-Jallow L; Sahin GO; Michaelsson J; Spangberg M; Thorstensson R; Fenyo E; Spetz A
- Doctoral thesis: 2002Michaëlsson J
Grants
- Swedish Research Council1 January 2025 - 31 December 2028Innate lymphoid cells (ILC), including NK cells, ILC1, ILC2, and ILC3, are involved in lymphoid tissue-development, infections, cancer, inflammation and tissue-repair. We have recently shown that ILCs develop early, with distinct distribution and gene expression depending on tissue. In this application we will investigate the development and diversity of human fetal ILCs and their progenitors at clonal level. We hypothesize that development from tissue-restricted ILC progenitors together with clonally heritable gene expression and the tissue environment shape the development and diversity of human ILCs across tissues. By analyzing somatic mutations in mitochondrial genes, coupled with gene and protein expression at single cell level we aim at performing lineage tracing based on mutational patterns in human fetal ILC across tissues. To verify the results from the in vivo fate mapping data and to gain further insight into ILC development, we will dissect the potential of individual CD34+ HPCs to differentiate to mature ILCs in vitro. Finally, we aim at determining clonally heritable gene expression (clonal memory) in ILCs, enabling us to assess to what extent clonal memory contributes to tissue-dependent differences, as well as to dissect gene expression regulation in ILCs. We believe that the proposed project is important for a better basic understanding of human fetal hematopoiesis, as well as for tissue-specific immunity and hematopoietic stem cell-based therapies.
- Dissecting human ILC development and differentiation at the clonal levelSwedish Research Council1 January 2025 - 31 December 2028
- Swedish Research Council1 January 2021 - 31 December 2024
- Swedish Research Council1 January 2017 - 31 December 2020
- Swedish Cancer Society
Employments
- Principal Researcher, Department of Medicine, Huddinge, Karolinska Institutet, 2022-
Degrees and Education
- Docent, Karolinska Institutet, 2015
- Doctor Of Philosophy, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2002