Jakob Michaelsson

About me
Publications
CV
Public outreach and news

About me

I am the group leader of the Jakob Michaelssons research group
[1] at the at the Center for Infectious Medicine, CIM at the Department of
Medicine Huddinge.
[1] https://ki.se/en/medh/jakob-michaelsson-group

Articles

Article: SCIENCE IMMUNOLOGY. 2024;9(94):eadj7168
Tissue-specific nonheritable influences drive endometrial immune system variation
Bister J; Filipovic I; Sun D; Crona-Guterstam Y; Cornillet M; Ponzetta A; Michaelsson J; Gidloef S; Ivarsson MA; Strunz B; Bjoerkstroem NK
Article: CELL SYSTEMS. 2024;15(2):149-165.e10
Clonally heritable gene expression imparts a layer of diversity within cell types
Mold JE; Weissman MH; Ratz M; Hagemann-Jensen M; Hard J; Eriksson C-J; Toosi H; Berghenstrahle J; Ziegenhain C; von Berlin L; Martin M; Blom K; Lagergren J; Lundeberg J; Sandberg R; Michaeeurolsson J; Frisen J
Article: ONCOIMMUNOLOGY. 2023;12(1):2233402
Accumulation of tissue-resident natural killer cells, innate lymphoid cells, and CD8⁺ T cells towards the center of human lung tumors
Brownlie D; von Kries A; Valenzano G; Wild N; Yilmaz E; Safholm J; Al-Ameri M; Alici E; Ljunggren H-G; Schliemann I; Aricak O; de Flon FH; Michaelsson J; Marquardt N
Article: SCIENCE. 2023;382(6675):1137
Spatial transcriptomics of B cell and T cell receptors reveals lymphocyte clonal dynamics
Engblom C; Thrane K; Lin Q; Andersson A; Toosi H; Chen X; Steiner E; Lu C; Mantovani G; Hagemann-Jensen M; Saarenpaa S; Jangard M; Saez-Rodriguez J; Michaelsson J; Hartman J; Lagergren J; Mold JE; Lundeberg J; Frisen J
Article: NATURE COMMUNICATIONS. 2023;14(1):5164
Long-read whole-genome analysis of human single cells
Hard J; Mold JE; Eisfeldt J; Tellgren-Roth C; Haggqvist S; Bunikis I; Contreras-Lopez O; Chin C-S; Nordlund J; Rubin C-J; Feuk L; Michaelsson J; Ameur A
Article: RESPIRATORY RESEARCH. 2023;24(1):62
Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia
Palma Medina LM; Babacic H; Dzidic M; Parke A; Garcia M; Maleki KT; Unge C; Lourda M; Kvedaraite E; Chen P; Muvva JR; Cornillet M; Emgard J; Moll K; Michaelsson J; Flodstrom-Tullberg M; Brighenti S; Buggert M; Mjosberg J; Malmberg K-JK; Sandberg J; Gredmark-Russ S; Rooyackers O; Svensson MJ; Chambers BI; Eriksson L; Pernemalm MK; Bjorkstrom N; Aleman S; Ljunggren H-G; Klingstrom J; Stralin K; Norrby-Teglund A
Article: NATURE CELL BIOLOGY. 2023;25(2):351-365
A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung
Sountoulidis A; Marco Salas S; Braun E; Avenel C; Bergenstrahle J; Theelke J; Vicari M; Czarnewski P; Liontos A; Abalo X; Andrusivova Z; Mirzazadeh R; Asp M; Li X; Hu L; Sariyar S; Martinez Casals A; Ayoglu B; Firsova A; Michaelsson J; Lundberg E; Waehlby C; Sundstroem E; Linnarsson S; Lundeberg J; Nilsson M; Samakovlis C
Article: CELL REPORTS. 2022;38(10):110503
SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells
Hammer Q; Dunst J; Christ W; Picarazzi F; Wendorff M; Momayyezi P; Huhn O; Netskar HK; Maleki KT; Garcia M; Sekine T; Sohlberg E; Azzimato V; Aouadi M; Degenhardt F; Franke A; Spallotta F; Mori M; Michaelsson J; Bjorkstrom NK; Rueckert T; Romagnani C; Horowitz A; Klingstrom J; Ljunggren H-G; Malmberg K-J
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:834862
Comparison of Lung-Homing Receptor Expression and Activation Profiles on NK Cell and T Cell Subsets in COVID-19 and Influenza
Brownlie D; Rodahl I; Varnaite R; Asgeirsson H; Glans H; Falck-Jones S; Vangeti S; Buggert M; Ljunggren H-G; Michaelsson J; Gredmark-Russ S; Smed-Sorensen A; Marquardt N
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(40):e2109123118
High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of in COVID-19
Lourda M; Dzidic M; Hertwig L; Bergsten H; Medina LMP; Sinha I; Kvedaraite E; Chen P; Muvva JR; Gorin J-B; Cornillet M; Emgard J; Moll K; Garcia M; Maleki KT; Klingstrom J; Michaelsson J; Flodstrom-Tullberg M; Brighenti S; Buggert M; Mjosberg J; Malmberg K-J; Sandberg JK; Henter J-I; Folkesson E; Gredmark-Russ S; Sonnerborg A; Eriksson LI; Rooyackers O; Aleman S; Stralin K; Ljunggren H-G; Bjorkstrom NK; Svensson M; Ponzetta A; Norrby-Teglund A; Chambers BJ
Article: CELLS. 2021;10(7):1713
In Vitro Study of Human Immune Responses to Hyaluronic Acid Hydrogels, Recombinant Spidroins and Human Neural Progenitor Cells of Relevance to Spinal Cord Injury Repair
Lin C; Ekblad-Nordberg A; Michaelsson J; Gotherstrom C; Hsu C-C; Ye H; Johansson J; Rising A; Sundstrom E; Akesson E
Article: SCIENCE TRANSLATIONAL MEDICINE. 2021;13(599):eabb3107
A biliary immune landscape map of primary sclerosing cholangitis reveals a dominant network of neutrophils and tissue-resident T cells
Zimmer CL; von Seth E; Buggert M; Strauss O; Hertwig L; Nguyen S; Wong AYW; Zotter C; Berglin L; Michaelsson J; Hansson MR; Arnelo U; Sparrelid E; Ellis ECS; Soderholm JD; Keita AV; Holm K; Ozenci V; Hov JR; Mold JE; Cornillet M; Ponzetta A; Bergquist A; Bjorkstrom NK
Article: CELL REPORTS. 2021;35(8):109174
Divergent clonal differentiation trajectories establish CD8⁺ memory T cell heterogeneity during acute viral infections in humans
Mold JE; Modolo L; Hard J; Zamboni M; Larsson AJM; Stenudd M; Eriksson C-J; Durif G; Stahl PL; Borgstrom E; Picelli S; Reinius B; Sandberg R; Reu P; Talavera-Lopez C; Andersson B; Blom K; Sandberg JK; Picard F; Michaelsson J; Frisen J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(11):e2016580118
Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood
Brownlie D; Scharenberg M; Mold JE; Hard J; Kekalainen E; Buggert M; Nguyen S; Wilson JN; Al-Ameri M; Ljunggren H-G; Marquardt N; Michaelsson J
Article: IMMUNITY. 2021;54(2):259-275.e7
Distinct developmental pathways from blood monocytes generate human lung macrophage diversity
Evren E; Ringqvist E; Tripathi KP; Sleiers N; Rives IC; Alisjahbana A; Gao Y; Sarhan D; Halle T; Sorini C; Lepzien R; Marquardt N; Michaelsson J; Smed-Sorensen A; Botling J; Karlsson MCI; Villablanca EJ; Willinger T
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:752104
CD5 Surface Expression Marks Intravascular Human Innate Lymphoid Cells That Have a Distinct Ontogeny and Migrate to the Lung
Alisjahbana A; Gao Y; Sleiers N; Evren E; Brownlie D; von Kries A; Jorns C; Marquardt N; Michaelsson J; Willinger T
Article: SCIENCE IMMUNOLOGY. 2020;5(50):eabd6832
Natural killer cell immunotypes related to COVID-19 disease severity
Maucourant C; Filipovic I; Ponzetta A; Aleman S; Cornillet M; Hertwig L; Strunz B; Lentini A; Reinius B; Brownlie D; Cuapio A; Ask EH; Hull RM; Haroun-Izquierdo A; Schaffer M; Klingstrom J; Folkesson E; Buggert M; Sandberg JK; Eriksson LI; Rooyackers O; Ljunggren H-G; Malmberg K-J; Michaelsson J; Marquardt N; Hammer Q; Stralin K; Bjorkstrom NK
Article: PLOS BIOLOGY. 2019;17(10):e3000383
Cell generation dynamics underlying naive T-cell homeostasis in adult humans
Mold JE; Reu P; Olin A; Bernard S; Michaelsson J; Rane S; Yates A; Khosravi A; Salehpour M; Possnert G; Brodin P; Frisen J
Article: NATURE COMMUNICATIONS. 2019;10(1):3841
Unique transcriptional and protein-expression signature in human lung tissue-resident NK cells
Marquardt N; Kekalainen E; Chen P; Lourda M; Wilson JN; Scharenberg M; Bergman P; Al-Ameri M; Hard J; Mold JE; Ljunggren H-G; Michaelsson J
Article: GENOME BIOLOGY. 2019;20(1):68
Conbase: a software for unsupervised discovery of clonal somatic mutations in single cells through read phasing
Hard J; Al Hakim E; Kindblom M; Bjorklund AK; Sennblad B; Demirci I; Paterlini M; Reu P; Borgstrom E; Stahl PL; Michaelsson J; Mold JE; Frisen J
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1116
Influenza A Virus Infection Induces Hyperresponsiveness in Human Lung Tissue-Resident and Peripheral Blood NK Cells
Scharenberg M; Vangeti S; Kekalainen E; Bergman P; Al-Ameri M; Johansson N; Sonden K; Falck-Jones S; Farnert A; Ljunggren H-G; Michaelsson J; Smed-Sorensen A; Marquardt N
Article: JOURNAL OF CROHN'S AND COLITIS. 2019;13(1):67-78
Distinct Alterations in the Composition of Mucosal Innate Lymphoid Cells in Newly Diagnosed and Established Crohn's Disease and Ulcerative Colitis
Forkel M; van Tol S; Hoog C; Michaelsson J; Almer S; Mjosberg J
Article: IMMUNOHORIZONS. 2018;2(6):172-184
Breadth and Dynamics of HLA-A2- and HLA-B7-Restricted CD8+ T Cell Responses against Nonstructural Viral Proteins in Acute Human Tick-Borne Encephalitis Virus Infection.
Lampen MH; Uchtenhagen H; Blom K; Varnaitė R; Pakalniene J; Dailidyte L; Wälchli S; Lindquist L; Mickiene A; Michaëlsson J; Schumacher TN; Ljunggren H-G; Sandberg JK; Achour A; Gredmark-Russ S
Article: BIOINFORMATICS. 2018;34(3):485-493
High dimensional classification with combined adaptive sparse PLS and logistic regression
Durif G; Modolo L; Michaelsson J; Mold JE; Lambert-Lacroix S; Picard F
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2017;47(8):1280-1294
Composition and functionality of the intrahepatic innate lymphoid cell-compartment in human nonfibrotic and fibrotic livers
Forkel M; Berglin L; Kekalainen E; Carlsson A; Svedin E; Michaelsson J; Nagasawa M; Erjefalt JS; Mori M; Flodstrom-Tullberg M; Bergquist A; Ljunggren H-G; Westgren M; Lindforss U; Friberg D; Jorns C; Ellis E; Bjorkstrom NK; Mjosberg J
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(4):1321-1330.e4
Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69^-CD56^dim cells
Marquardt N; Kekalainen E; Chen P; Kvedaraite E; Wilson JN; Ivarsson MA; Mjosberg J; Berglin L; Safholm J; Manson ML; Adner M; Al-Ameri M; Bergman P; Orre A-C; Svensson M; Dahlen B; Dahlen S-E; Ljunggren H-G; Michaelsson J
Article: IMMUNITY. 2017;46(2):287-300
CD49a Expression Defines Tissue-Resident CD8⁺ T Cells Poised for Cytotoxic Function in Human Skin
Cheuk S; Schlums H; Serezal IG; Martini E; Chiang SC; Marquardt N; Gibbs A; Detlofsson E; Introini A; Forkel M; Hoog C; Tjernlund A; Michaelsson J; Folkersen L; Mjosberg J; Blomqvist L; Ehrstrom M; Stahle M; Bryceson YT; Eidsmo L
Article: NATURE GENETICS. 2016;48(11):1430-1435
Analysis of allelic expression patterns in clonal somatic cells by single-cell RNA-seq
Reinius B; Mold JE; Ramskold D; Deng Q; Johnsson P; Michaelsson J; Frisen J; Sandberg R
Article: JOURNAL OF IMMUNOLOGY. 2016;197(8):3069-3075
Fetal CD103⁺ IL-17-Producing Group 3 Innate Lymphoid Cells Represent the Dominant Lymphocyte Subset in Human Amniotic Fluid
Marquardt N; Ivarsson MA; Sundstrom E; Akesson E; Martini E; Eidsmo L; Mjosberg J; Friberg D; Kublickas M; Ek S; Tegerstedt G; Seiger A; Westgren M; Michaelsson J
Article: JOURNAL OF IMMUNOLOGY. 2016;197(7):2762-2771
NK Cell Responses to Human Tick-Borne Encephalitis Virus Infection
Blom K; Braun M; Pakalniene J; Lunemann S; Enqvist M; Dailidyte L; Schaffer M; Lindquist L; Mickiene A; Michaelsson J; Ljunggren H-G; Gredmark-Russ S
Article: JOURNAL OF IMMUNOLOGY. 2015;195(7):3262-3272
The Human NK Cell Response to Yellow Fever Virus 17D Is Primarily Governed by NK Cell Differentiation Independently of NK Cell Education
Marquardt N; Ivarsson MA; Blom K; Gonzalez VD; Braun M; Falconer K; Gustafsson R; Fogdell-Hahn A; Sandberg JK; Michaelsson J
Article: IMMUNITY. 2015;43(2):394-407
Identification of a Human Natural Killer Cell Lineage-Restricted Progenitor in Fetal and Adult Tissues
Renoux VM; Zriwil A; Peitzsch C; Michaelsson J; Friberg D; Soneji S; Sitnicka E
Article: JOURNAL OF IMMUNOLOGY. 2015;194(6):2467-2471
Cutting Edge: Identification and Characterization of Human Intrahepatic CD49a⁺ NK Cells
Marquardt N; Beziat V; Nystrom S; Hengst J; Ivarsson MA; Kekalainen E; Johansson H; Mjosberg J; Westgren M; Lankisch TO; Wedemeyer H; Ellis EC; Ljunggren H-G; Michaelsson J; Bjorkstrom NK
Article: PLOS PATHOGENS. 2015;11(1):e1004622
Specificity and Dynamics of Effector and Memory CD8 T Cell Responses in Human Tick-Borne Encephalitis Virus Infection
Blom K; Braun M; Pakalniene J; Dailidyte L; Beziat V; Lampen MH; Klingstrom J; Lagerqvist N; Kjerstadius T; Michaelsson J; Lindquist L; Ljunggren H-G; Sandberg JK; Mickiene A; Gredmark-Russ S
Article: MUCOSAL IMMUNOLOGY. 2014;7(5):1233-1243
Invariant natural killer T cells developing in the human fetus accumulate and mature in the small intestine
Loh L; Ivarsson MA; Michaelsson J; Sandberg JK; Nixon DF
Article: PLOS PATHOGENS. 2014;10(7):e1004251
T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+T Cells in HIV Infection
Buggert M; Tauriainen J; Yamamoto T; Frederiksen J; Ivarsson MA; Michaelsson J; Lund O; Hejdeman B; Jansson M; Sonnerborg A; Koup RA; Betts MR; Karlsson AC
Article: JOURNAL OF CLINICAL INVESTIGATION. 2013;123(9):3889-3901
Differentiation and functional regulation of human fetal NK cells
Ivarsson MA; Loh L; Marquardt N; Kekalainen E; Berglin L; Bjorkstrom NK; Westgren M; Nixon DF; Michaelsson J
Article: BLOOD. 2013;121(14):2678-2688
NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs
Beziat V; Liu LL; Malmberg J-A; Ivarsson MA; Sohlberg E; Bjorklund AT; Retiere C; Sverremark-Ekstrom E; Traherne J; Ljungman P; Schaffer M; Price DA; Trowsdale J; Michaelsson J; Ljunggren H-G; Malmberg K-J
Article: JOURNAL OF IMMUNOLOGY. 2013;190(5):2150-2158
Temporal Dynamics of the Primary Human T Cell Response to Yellow Fever Virus 17D As It Matures from an Effector- to a Memory-Type Response
Blom K; Braun M; Ivarsson MA; Gonzalez VD; Falconer K; Moll M; Ljunggren H-G; Michaelsson J; Sandberg JK
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2011;41(8):2279-2290
The inflammatory milieu in the rheumatic joint reduces regulatory T-cell function
Herrath J; Muller M; Amoudruz P; Janson P; Michaelsson J; Larsson PT; Trollmo C; Raghavan S; Malmstrom V
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2011;73(2):141-146
NK Cells and CD1d-restricted NKT Cells Respond in Different Ways with Divergent Kinetics to IL-2 Treatment in Primary HIV-1 Infection
Kuylenstierna C; Snyder-Cappione JE; Loo CP; Long BR; Gonzalez VD; Michaelsson J; Moll M; Spotts G; Hecht FM; Nixon DF; Sandberg JK
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2011;208(1):13-21
Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus
Bjorkstrom NK; Lindgren T; Stoltz M; Fauriat C; Braun M; Evander M; Michaelsson J; Malmberg K-J; Klingstrom J; Ahlm C; Ljunggren H-G
Article: SCIENCE. 2010;330(6011):1695-1699
Fetal and Adult Hematopoietic Stem Cells Give Rise to Distinct T Cell Lineages in Humans
Mold JE; Venkatasubrahmanyam S; Burt TD; Michaelsson J; Rivera JM; Galkina SA; Weinberg K; Stoddart CA; McCune JM
Article: BLOOD. 2010;116(19):3853-3864
Expression patterns of NKG2A, KIR, and CD57 define a process of CD56^dim NK-cell differentiation uncoupled from NK-cell education
Bjorkstrom NK; Riese P; Heuts F; Andersson S; Fauriat C; Ivarsson MA; Bjorklund AT; Flodstrom-Tullberg M; Michaelsson J; Rottenberg ME; Guzman CA; Ljunggren H-G; Malmberg K-J
Article: BLOOD. 2010;115(6):1166-1174
Education of human natural killer cells by activating killer cell immunoglobulin-like receptors
Fauriat C; Ivarsson MA; Ljunggren H-G; Malmberg K-J; Michaelsson J
Article: BLOOD. 2009;114(23):4823-4831
Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by coexpression of CD56, CD7, and CD4
Milush JM; Long BR; Snyder-Cappione JE; Cappione AJIII; York VA; Ndhlovu LC; Lanier LL; Michaelsson J; Nixon DF
Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2009;25(6):603-605
HIV-1-Specific T Cell-Dependent Natural Killer (NK) Cell Activation: Major Contribution by NK Cells to Interferon-γ Production in Response to HIV-1 Antigens
Loo CP; Long BR; Hecht FM; Nixon DF; Michaelsson J
Article: SCIENCE. 2008;322(5907):1562-1565
Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero
Mold JE; Michaelsson J; Burt TD; Muench MO; Beckerman KP; Busch MP; Lee T-H; Nixon DF; McCune JM
Article: JOURNAL OF IMMUNOLOGY. 2008;181(9):6010-6019
Estimation of the Size of the Alloreactive NK Cell Repertoire: Studies in Individuals Homozygous for the Group A KIR Haplotype
Fauriat C; Andersson S; Bjorklund AT; Carlsten M; Schaffer M; Bjorkstrom NK; Baumann BC; Michaelsson J; Ljunggren H-G; Malmberg K-J
Article: BMC IMMUNOLOGY. 2008;9:41
The frequency of CD127^low expressing CD4⁺CD25^high T regulatory cells is inversely correlated with human T lymphotrophic virus type-1 (HTLV-1) proviral load in HTLV-1-infection and HTLV-1-associated myelopathy/tropical spastic paraparesis
Michaelsson J; Barbosa HMR; Jordan KA; Chapman JM; Brunialti MKC; Neto WK; Nukui Y; Sabino EC; Chieia MA; Bulle Oiliveira AS; Nixon DF; Kallas EG
Article: CLINICAL IMMUNOLOGY. 2008;128(1):46-56
Expansion of CD56^- NK cells in chronic HCV/HIV-1 co-infection:: Reversion by antiviral treatment with pegylated IFNα and ribavirin
Gonzalez VD; Falconer K; Michaelsson J; Moll M; Reichard O; Alaeus A; Sandberg JK
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2008;330(1-2):64-74
Application of nine-color flow cytometry for detailed studies of the phenotypic complexity and functional heterogeneity of human lymphocyte subsets
Gonzalez VD; Bjorkstroem NK; Malmberg K-J; Moll M; Kuylenstierna C; Michalsson J; Ljunggren H-G; Sandberg JK
Article: JOURNAL OF INFECTIOUS DISEASES. 2008;197(1):117-125
Immune reconstitution of CD56^dim NK cells in individuals with primary HIV-1 infection treated with interleukin-2
Michaelsson J; Long BR; Loo CP; Lanier LL; Spotts G; Hecht FM; Nixon DF
Article: CLINICAL AND VACCINE IMMUNOLOGY. 2008;15(1):120-130
Elevated frequency of gamma interferon-producing NK cells in healthy adults vaccinated against influenza virus
Long BR; Michaelsson J; Loo CP; Ballan WM; Vu B-AN; Hecht FM; Lanier LL; Chapman JM; Nixon DF
Article: IMMUNOLOGY. 2007;122(2):291-301
Activating and inhibitory receptors on synovial fluid natural killer cells of arthritis patients:: role of CD94/NKG2A in control of cytokine secretion
de Matos CT; Berg L; Michaelsson J; Fellander-Tsai L; Kaerre K; Soederstroem K
Article: JOURNAL OF IMMUNOLOGY. 2007;179(5):3362-3370
Natural killer cells in perinatally HIV-1-infected children exhibit less degranulation compared to HIV-1-exposed uninfected children and their expression of KIR2DL3, NKG2C, and NKp46 correlates with disease severity
Ballan WM; Vu B-AN; Long BR; Loo CP; Michaelsson J; Barbour JD; Lanier LL; Wiznia AA; Abadi J; Fennelly GJ; Rosenberg MG; Nixon DF
Article: JOURNAL OF VIROLOGY. 2007;81(11):5759-5765
Human immunodeficiency virus type 1 (HIV-1)-specific CD8⁺ T_EMRA cells in early infection are linked to control of HIV-1 viremia and predict the subsequent viral load set point
Northfield JW; Loo CP; Barbour JD; SpottS G; Hecht FM; Klenerman P; Nixon DF; Michaelsson J
Article: JOURNAL OF IMMUNOLOGY. 2007;178(2):647-651
Cutting edge:: KIR3DS1, a gene implicated in resistance to progression to AIDS, encodes a DAP12-associated receptor expressed on NK cells that triggers NK cell activation
Carr WH; Rosen DB; Arase H; Nixon DF; Michaelsson J; Lanier LL
Article: JOURNAL OF IMMUNOLOGY. 2006;176(10):5741-5748
Regulation of T cell responses in the developing human fetus.
Michaëlsson J; Mold JE; McCune JM; Nixon DF
Article: JOURNAL OF MOLECULAR BIOLOGY. 2006;356(2):382-396
Structural basis of the differential stability and receptor specificity of H-2D^b in complex with murine versus human β₂-microglobulin
Achour A; Michaëlsson T; Harris RA; Ljunggren HG; Kärre M; Schneider G; Sandalova T
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2005;61(Pt 12):1090-1093
Expression, refolding and crystallization of murine MHC class IH-2D^b in complex with human β₂-microglobulin
Sandalova T; Michaëlsson J; Harris RA; Ljunggren HG; Kärre K; Schneider G; Achour A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(29):27069-27075
A structural basis for CD8⁺ T cell-dependent recognition of non-homologous peptide ligands -: Implications for molecular mimicry in autoreactivity
Sandalova T; Michaëlsson J; Harris RA; Odeberg J; Schneider G; Kärres K; Achour A
Article: MICROBES AND INFECTION. 2005;7(7-8):1063-1065
CD4+CD25+ regulatory T cells in HIV infection.
Nixon DF; Aandahl EM; Michaëlsson J
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2004;34(6):1646-1653
Loss or mismatch of MHC class I is sufficient to trigger NK cell-mediated rejection of resting lymphocytes in vivo -: role of KARAP/DAP12-dependent and -independent pathways
Öberg L; Johansson S; Michaëlsson J; Tomasello E; Vivier E; Kärre K; Höglund P
Article: JOURNAL OF IMMUNOLOGY. 2004;172(9):5504-5511
Determination of structural principles underlying three different modes of lymphocytic choriomeningitis virus escape from CTL recognition
Velloso LM; Michaëlsson J; Ljunggren HG; Schneider G; Achour A
Article: JOURNAL OF VIROLOGY. 2004;78(5):2454-2459
Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens.
Aandahl EM; Michaëlsson J; Moretto WJ; Hecht FM; Nixon DF
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2003;33(10):2727-2735
Regulation of perforin-independent NK cell-mediated cytotoxicity
Wallin RPA; Screpanti V; Michaëlsson J; Grandien A; Ljunggren HG
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2002;196(11):1403-1414
A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition
Michaëlsson J; de Matos CT; Achour A; Lanier LL; Kärre K; Söderström K
Article: IMMUNITY. 2002;17(6):757-768
A structural basis for LCMV immune evasion:: Subversion of H-2D^b and H-2K^b presentation of gp33 revealed by comparative crystal structure analyses
Achour A; Michaëlsson J; Harris RA; Odeberg J; Grufman P; Sandberg JK; Levitsky V; Kärre K; Sandalova T; Schneider G
Article: CANCER RESEARCH. 2002;62(4):1116-1122
Apoptosis-dependent subversion of the T-lymphocyte epitope hierarchy in lymphoma cells
Castiglioni P; Martin-Fontecha A; Milan G; Tomajer V; Magni F; Michaelsson J; Rugarli C; Rosato A; Bellone M
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2002;55(2):129-139
The role of an exposed loop in the α₂ domain in the mouse MHC class IH-2D_d molecule for recognition by the monoclonal antibody 34-5-8S and the NK-cell receptor Ly49A
Waldenström M; Achour A; Michaelsson J; Rölle A; Kärre K
Article: JOURNAL OF IMMUNOLOGY. 2002;168(2):793-800
NK cell inhibitory receptor Ly-49C residues involved in MHC class I binding
Sundbäck J; Achour A; Michaëlsson J; Lindström H; Kärre K
Article: JOURNAL OF IMMUNOLOGY. 2001;166(12):7327-7334
MHC class I recognition by NK receptors in the Ly49 family is strongly influenced by the β₂-microglobulin subunit
Michaëlsson J; Achour A; Rölle A; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2001;31(3):869-875
Purified MHC class I molecules inhibit activated NK cells in a cell-free system in vitro
Kambayashi T; Michaëlsson J; Fahlén L; Chambers BJ; Sentman CL; Kärre K; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 2000;165(9):4964-4969
Emergence of CD8⁺ T cells expressing NK cell receptors in influenza A virus-infected mice
Kambayashi T; Assarsson E; Michaëlsson J; Berglund P; Diehl AP; Chambers BJ; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 2000;165(1):25-33
T cell tolerance based on avidity thresholds rather than complete deletion allows maintenance of maximal repertoire diversity
Sandberg JK; Franksson L; Sundbäck J; Michaelsson J; Petersson M; Achour A; Wallin RPA; Sherman NE; Bergman T; Jörnvall H; Hunt DF; Kiessling R; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2000;30(1):300-307
Visualization of inhibitory Ly49 receptor specificity with soluble major histocompatibility complex class I tetramers
Michaëlsson J; Achour A; Salcedo M; Kåse-Sjöström A; Sundbäck J; Harris RA; Kärre K
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Review: FRONTIERS IN IMMUNOLOGY. 2018;9:2174
Cell-Mediated Immune Responses and Immunopathogenesis of Human Tick-Borne Encephalitis Virus-Infection
Blom K; Cuapio A; Sandberg JT; Varnaite R; Michaelsson J; Bjorkstrom NK; Sandberg JK; Klingstrom J; Lindquist L; Russ SG; Ljunggren H-G
Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;140(1):318
Polyfunctionality of bona fide resident lung CD69⁺ natural killer cells Reply
Marquardt N; Ljunggren H-G; Michaelsson J
Review: NATURE REVIEWS IMMUNOLOGY. 2016;16(5):310-320
Emerging insights into natural killer cells in human peripheral tissues
Bjorkstrom NK; Ljunggren H-G; Michaelsson J
Editorial comment: EUROPEAN JOURNAL OF IMMUNOLOGY. 2014;44(7):2192-2196
Tracing dynamic expansion of human NK-cell subsets by high-resolution analysis of KIR repertoires and cellular differentiation
Beziat V; Traherne J; Malmberg J-A; Ivarsson MA; Bjorkstrom NK; Retiere C; Ljunggren H-G; Michaelsson J; Trowsdale J; Malmberg K-J
Review: FRONTIERS IN IMMUNOLOGY. 2014;5:184-9
Activating killer cell Ig-like receptors In health and disease
Ivarsson MA; Michaelsson J; Fauriat C
Other: IMMUNITY. 2011;35(5):653-657
Killer Cell Immunoglobulin-like Receptor Workshop: Insights into Evolution, Genetics, Function, and Translation
Malmberg K-J; Michaelsson J; Parham P; Ljunggren H-G
Meeting abstract: RETROVIROLOGY. 2009;6:p23
Preserved cellular and humoral immune responses in macaques infected with SIVmac239 and subjected to early antiretroviral therapy
Makitalo B; Walther-Jallow L; Sahin GO; Michaelsson J; Spangberg M; Thorstensson R; Fenyo E; Spetz A
Thesis / dissertation: 2002
Decoding NK cell receptor specificity : functional and structural studies of MHC class 1 subcomponents
Michaëlsson, Jakob

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Principal Researcher, Department of Medicine, Huddinge, Karolinska Institutet, 2022-

Degrees and Education

Docent, Karolinska Institutet, 2015
Doctor Of Philosophy, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2002

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