Gefei Chen
About me
I gained my PhD in Biochemistry and Molecular Biology, and developed a strong foundation in protein biochemistry throughout my subsequent postdoctoral training from 2014 to 2019. My career progressed through roles as an Assistant Professor in medical protein biochemistry from 2019 to 2023, where I focused on molecular mechanisms and potential treatments of a molecular chaperone domain for neurodegenerative diseases, among other projects. Currently, I hold a position as a Principal Researcher, with focusing on medical protein biochemistry and structure biology.
Research
Proteins can unfold and assemble into both pathogenic and functional amyloid fibrils, which are relevant to human diseases, bacterial infections, and biomaterials. Our research aims to understand the mechanisms underlying these different types of amyloid formation and to search for natural and engineered strategies to inhibit amyloid aggregation. Our goal is to develop therapeutic approaches for human diseases and combat bacterial infections. In parallel, we are interested in the mechanisms and functions of amyloid assemblies in natural silk fibers, with an eye toward their applications in biomaterials.
Teaching
I have actively contributed to undergraduate and postgraduate education through lectures, seminars, laboratory courses, and the supervision of BSc, MSc, Ph.D. students, and postdoctoral researchers. Over the past six years, I have completed 180+ teaching hours across course instruction and thesis supervision. My teaching experience spans Karolinska Institutet and Uppsala University, covering subjects such as biomedicine and molecular biophysics. Although my current position as Principal Researcher is primarily research-focused, I remain committed to education and voluntarily contribute approximately 35 hours annually.
Selected publications
- Journal article: ADVANCED FUNCTIONAL MATERIALS. 2025;35(15)
- Journal article: ADVANCED FUNCTIONAL MATERIALS. 2025;35(15)
- Article: NEURAL REGENERATION RESEARCH. 2024;19(11):2343-2344
- Article: TRANSLATIONAL PSYCHIATRY. 2024;14(1):453
- Article: PROTEIN SCIENCE. 2024;33(7):e5063
- Journal article: MEDCOMM. 2024;5(7):e573
- Article: ADVANCED FUNCTIONAL MATERIALS. 2024;34(23)
- Journal article: ADVANCED FUNCTIONAL MATERIALS. 2024;34(23)
- Article: SMALL. 2023;19(46):e2304031
- Article: COMMUNICATIONS BIOLOGY. 2023;6(1):497
- Article: PROGRESS IN NEUROBIOLOGY. 2022;219:102366
- Article: RSC CHEMICAL BIOLOGY. 2022;3(11):1342-1358
- Article: ACS CHEMICAL BIOLOGY. 2022;17(8):2201-2211
- Article: ACS BIOMATERIALS SCIENCE & ENGINEERING. 2022;8(1):119-127
- Article: COMMUNICATIONS BIOLOGY. 2020;3(1):32
- Article: NATURE COMMUNICATIONS. 2017;8(1):2081
- Article: CHEMBIOCHEM. 2015;16(12):1720-1724
- Journal article: CHEMBIOCHEM. 2015;16(12):1824
- Article: PLOS BIOLOGY. 2014;12(8):e1001921
- Article: PLOS ONE. 2012;7(12):e52293
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Articles
- Journal article: ALZHEIMERS & DEMENTIA. 2024;20 Suppl 1:e089371
- Journal article: ALZHEIMERS & DEMENTIA. 2024;20(Suppl 9):e093828
- Article: JOURNAL OF ALZHEIMERS DISEASE. 2024;101(3):787-796
- Article: BIOORGANIC CHEMISTRY. 2024;147:107373
- Article: PROGRESS IN NEUROBIOLOGY. 2024;235:102585
- Journal article: JOURNAL OF FUNCTIONAL FOODS. 2024;113:106041
- Journal article: NATURE COMMUNICATIONS. 2024;15(1):965
- Article: NATURE COMMUNICATIONS. 2024;15(1):965
- Article: EXPERIMENTAL NEUROLOGY. 2023;369:114545
- Journal article: IBRO REPORTS. 2023;15:s447
- Article: BIOLOGY-BASEL. 2023;12(6):805
- Article: PNAS NEXUS. 2023;2(2):pgac303
- Article: MOLECULAR THERAPY. 2023;31(2):487-502
- Article: NATURE COMMUNICATIONS. 2022;13(1):4695
- Article: FREE RADICAL BIOLOGY AND MEDICINE. 2022;188:194-205
- Article: PROTEIN SCIENCE. 2022;31(8):e4378
- Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2022;10(1):96
- Article: STRUCTURE. 2022;30(5):733-742.e7
- Article: FRONTIERS IN MOLECULAR BIOSCIENCES. 2022;9:812808
- Article: NEUROBIOLOGY OF DISEASE. 2021;159:105514
- Article: SCIENTIFIC REPORTS. 2021;11(1):21069
- Article: MICROBIAL CELL FACTORIES. 2021;20(1):150
- Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2021;198:113996
- Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):212
- Article: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2021;8:650848
- Article: JOURNAL OF PHYSIOLOGY-LONDON. 2020;598(17):3711-3725
- Article: BMC BIOTECHNOLOGY. 2020;20(1):37
- Article: FEBS JOURNAL. 2020;287(13):2823-2833
- Article: SCIENTIFIC REPORTS. 2020;10(1):9817
- Article: SCIENTIFIC REPORTS. 2020;10(1):235
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(8):2606-2615
- Article: FEBS JOURNAL. 2018;285(10):1873-1885
- Article: CHINESE JOURNAL OF BIOTECHNOLOGY. 2016;32(12):1704-1714
- Article: BIOCHEMICAL JOURNAL. 2016;473(20):3683-3704
- Article: BIOPOLYMERS. 2016;105(7):385-392
- Article: CHINESE JOURNAL OF BIOTECHNOLOGY. 2014;30(8):1308-1317
- Article: NATURE COMMUNICATIONS. 2014;5:3254
- Article: CHINESE JOURNAL OF BIOTECHNOLOGY. 2013;29(9):1323-1331
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All other publications
- Review: COMMUNICATIONS CHEMISTRY. 2024;7(1):260
- Letter: NANO LETTERS. 2023;23(12):5836-5841
- Review: PROTEIN SCIENCE. 2023;32(6):e4645
- Conference publication: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2023;52(SUPPL 1):S54
- Preprint: BIORXIV. 2022
- Preprint: RESEARCH SQUARE. 2021
- Preprint: BIORXIV. 2021
- Preprint: SSRN ELECTRONIC JOURNAL. 2021
- Preprint: RESEARCH SQUARE. 2020
- Preprint: RESEARCH SQUARE. 2020
- Preprint: RESEARCH SQUARE. 2019
- Meeting abstract: AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS. 2019;26(sup1):152-153
- Conference publication: PROTEIN SCIENCE. 2017;26:18-19
- Conference publication: PROTEIN SCIENCE. 2017;26:31-32
Grants
- U.S. Alzheimer's Association Research GrantAlzheimer's Association, U.S.1 September 2022 - 31 August 2025
- BRI2 role in neuronal differentiation and the underlying molecular mechanisms: towards an innovative regenerative therapy for Alzheimer’s DiseaseFundação para a Ciência e Tecnologia1 January 2022 - 31 December 2025
Employments
- Principal Researcher, Department of Medicine, Huddinge, Karolinska Institutet, 2024-
Degrees and Education
- Docent, Karolinska Institutet, 2025