Andrea Carmine Belin

Andrea Carmine Belin

Senior Forskare | Docent
Telefon: +46852487051
Besöksadress: Solnavägen 9, 17165 Solna
Postadress: C4 Neurovetenskap, C4 Forskning Carmine Belin, 171 77 Stockholm

Forskningsbeskrivning

  • Syftet med vår forskning är att öka förståelsen av patofysiologin bakom
    neurologiska sjukdomar med fokus på huvudvärk, främst Hortons
    huvudvärk/klusterhuvudvärk, genom att identifiera, karakterisera och
    modellera genetiska markörer inom det mänskliga genomet.

Artiklar

Alla övriga publikationer

Forskningsbidrag

  • Swedish Research Council
    1 January 2026 - 31 December 2029
    Cluster headache (CH) is a severe disabling condition which strikes as an excruciating unilateral pain and there is no cure. It is more common among men, but more severe among women and sleep deficiencies have been reported. Genetics, circadian rhythm and inflammation have been implicated in CH pathophysiology. The overall purpose of this research project is to understand the molecular mechanisms and clinical characteristics of CH in order improve diagnosis and treatment by identifying biomarkers and novel drug targets, as well as develop future treatment strategies. This will be achieved by the following specific aims: 1) Characterize candidate genes coupled to CH pathophysiology2) Explore sleep and circadian rhythm in relation to CH and treatment3) Validate sex hormones with regard to CH characteristics4) Identify inflammatory mechanisms involved in CH5) Develop and characterize cell models of CH pathophysiologyThese aims will be achieved by using a worldleading CH biobank comprising biological tissue and clinical and demographic data. The research team has a unique position to execute the proposed project during a five-year period due to its complementary multidisciplinary expertise, in key areas such as genetics, cell biology, bioinformatics, circadian rhythm and neurology. These studies will allow insight into the pathophysiological mechanisms and aid the identification of biomarkers and disease-associated pathways suitable to target in the development of novel drugs.
  • Mapping of the mechanisms behind cluster headache with a focus on inflammation
    Hjärnfonden
    1 July 2023 - 31 December 2025
  • In depth characterization of genetic markers behind primary headache disorders with a focus on cluster headache
    Hjärnfonden
    1 July 2022 - 31 December 2024
  • Deciphering the mechanisms behind primary headache disorders with focus on genetics and circadian rhythm
    Karolinska Institutet
    1 January 2021 - 31 December 2024
  • Validering av läkemedelsrespons vid Hortons huvudvärk kopplat till genetik och dygnsrytm.
    Region Stockholm
    1 January 2021 - 31 December 2023
  • Genetic screening of Cluster headache in relation to treatment and circadian rhythm
    Hjärnfonden
    1 July 2020 - 31 December 2022

Anställningar

  • Senior Forskare, Neurovetenskap, Karolinska Institutet, 2022-

Examina och utbildning

  • Docent, Neurovetenskap, Karolinska Institutet, 2011
  • MEDICINE DOKTORSEXAMEN, Neurovetenskap, On Parkinson’s Disease and Schizophrenia: Case Control Studies, Cellular Localization and Modelling of Candidate Genes, Institutionen för neurovetenskap, Karolinska Institutet, 2003
  • Medicine Magisterexamen, Karolinska Institutet, 1999

Priser och utmärkelser

  • Cluster Headache Award, Headache Science and Neurorehabilitation Unit, University of Pavia, 2024
  • Svenska Migränsällskapets stipendium, Swedish Headache Society, 2014
  • Top-Cited Paper Award, Top-cited paper award for “Parkinson's disease: a genetic perspective“ published in the FEBS Journal Volume 275, issue 7, 2008., Federation of European Biochemical Societies, 2008
  • Special grant for younger scientists, Awarded with the special grants available for young scientists, establishing their own research projects., Karolinska Institutet, 2008
  • Postdoc-stipend, Hjärnfonden, 2005

Handledning

Uppdrag i kommitté

Utvärdering av avhandlingsarbete

Redaktör för vetenskaplig tidskrift

Sakkunniggranskning för vetenskaplig tidskrift

  • Movement Disorders
  • Brain Research
  • Journal of Neurology
  • Environment International
  • Neuroscience Letters
  • Microarrays, MDPI
  • Genetics Research
  • The Journal of Biomedical Science
  • Scientific Reports
  • Neuropsychiatric Disease and Treatment
  • BioMed research international
  • Journal of Pain Research
  • Neurotoxicology
  • EBioMedicine
  • Cephalalgia Reports
  • PLOS ONE
  • The Journal of Headache and Pain
  • JAMA Neurology
  • Expert Opinion On Pharmacotherapy
  • Frontiers in Neurology
  • Cephalalgia
  • Headache
  • Neurology
  • Current Medical Research & Opinion
  • Brain Sciences

Expert

  • Evaluator of major research grant applications in local competition, Karolinska Institutet Research Funds, Karolinska Institutet, 2022-2024
  • Evaluator of major research grant applications in local competition, Grant reviewer of KID-applications, KID funding is a block grant for partial financing of doctoral education at KI., Karolinska Institutet, 2021-2022

Konferenser och events

  • Moderator, International Headache Congress, Update on trigeminal autonomic cephalalgias, 2023
  • Inbjuden föredragshållare, International Headache Congress, Recent developments in the genetics of cluster headache, 2023
  • Moderator, International Headache Congress, Headache Trainees Excellence Tournament, 2023
  • Inbjuden föredragshållare, European Headache Congress, https://headache-congress.org/, Genetics in migraine, 2023
  • Inbjuden föredragshållare, Lundbeck R&D oragnization – Idea Forum, Cluster Headache – The alarm clock of pain, 2023
  • Inbjuden föredragshållare, Regional Headache Conference, https://ihs-headache.org/en/resources/ihs-regional-headache-conference/, The genetics of cluster headache, 2022
  • Inbjuden föredragshållare, Nordic Migraine Symposium, https://www.nordicmigrainesymposium.com/, Biomarkers - with focus on genetics, 2022
  • Inbjuden föredragshållare, Framtidens migränvård - danska och svenska lärdomar, Hur bli världsledande inom klusterhuvudvärk och genetikforskning, 2022
  • Muntlig presentation av inskickat abstract, International Headache Congress, Circadian rhythm gene expression in cluster headache, 2019
  • Moderator, Nordic Neuroscience Meeting, https://www.helsinki.fi/en/conferences/3rd-nordic-neuroscience-meeting-2019, Cluster headache and migraine genetics - new insights, 2019
  • Muntlig presentation av inskickat abstract, Migraine Trust International Symposium, Involvement of CGRP receptor RAMP1 in cluster headache – A Swedish case-control study, 2018
  • Poster-presentation av inskickat abstract, International Headache Congress, Cluster Headache – Clinical pattern and a new severity scale in a Swedish cohort, 2017

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