Utveckling och regenerering av könsceller – Alves-Lopes team

Publikationer

Alla gruppmedlemmars publikationer

• Journal article: HUMAN REPRODUCTION OPEN. 2026

  PFOS disrupts the development of early germline and surrounding embryonic soma at environmentally relevant exposure levels

  Pérez Casasús S; Nic Aodha L; Macedo T; Youhanna S; Luongo FP; Governini L; Luddi A; Piomboni P; Herold N; Jahnukainen K; Zhong Y; Damdimopoulou P; Lauschke VM; Alves-Lopes JP
• Article: EUROPEAN JOURNAL OF MEDICAL GENETICS. 2026;84:105104

  Neurofibromatosis 1 (NF1) gene testing reveals rising variant allele fraction as an early warning sign of juvenile myelomonocytic leukemia.

  Peltonen S; Johansson C; Grönroos M; Paavola M; Jahnukainen K; Ryhänen S; Wallgren-Pettersson C; Pöyhönen M; Riihilä P; Peltonen J; Haanpää MK
• Article: PEDIATRIC BLOOD & CANCER. 2026;73(9):e70513

  Measurable Residual Disease Monitoring During Treatment for Pediatric Acute Myeloid Leukemia in First Relapse.

  Poulsen C; Sandahl KJ; Karlsson L; Abrahamsson J; Arad-Cohen N; Cheuk D; De Moerloose B; Fogelstrand L; Navarro JMF; Goemans BF; Jahnukainen K; Kaspers G; Kovalova Z; Munthe-Kaas MC; Norén-Nyström U; Palle J; Pasauliene R; Pronk CJ; Saks K; Tierens A; Hasle H; Juul-Dam KL
• Article: JCI INSIGHT. 2026;11(11):e198098

  Pan-cancer polygenic risk score associates with cancer susceptibility following kidney transplantation.

  Ritari J; Hyvärinen K; Jahnukainen K; FinnGen Consortium; Partanen J; Helanterä I; Jahnukainen T
• Article: HUMAN REPRODUCTION OPEN. 2026;2026(3):hoag054

  Human iPSCs derived from cryopreserved testicular somatic cells enable germline regeneration in childhood cancer survivors.

  Macedo T; De Guidi C; Nic Aodha L; Rao Boggavarapu N; Piechocka M; Ye X; Mastropasqua F; Keros V; Norén Nyström U; Frisk P; Johansson P; Tammimies K; Baert Y; Jahnukainen K; Stukenborg J-B; Alves-Lopes JP
• Letter: LEUKEMIA. 2026;40(5):1044-1048

  Testicular organoids formation from leukaemia-infiltrated prepubertal testicular tissue: implications for fertility preservation

  Cui Y; Lohi J; Lindskog C; Jahnukainen K; Stukenborg J-B
• Article: BLOOD ADVANCES. 2026;10(7):2525-2537

  Allogeneic hematopoietic stem cell transplantation in ERCC6L2 disease

  Hakkarainen M; de Fontbrune FS; Kaaja I; Douglas S; Dalle J-H; Risitano AM; Kulasekararaj A; Alsultan A; Cutler C; Ho VT; Hellstrom-Lindberg E; Mielke S; Myhre AE; Rihani R; Abu Shanap M; Hashem H; Shimamura A; Rowe RG; Auer F; Beier F; Desnica L; Hough R; Jafri SRA; Ayas M; Jardine L; Mellid EF; Corrales I; Richardson D; Ozbek NY; Zaniewska-Tekieli A; Gozdzik J; Ryhanen S; Niinimaki R; Jahnukainen K; Salmenniemi U; Kilpivaara O; Wartiovaara-Kautto U
• Review: HUMAN REPRODUCTION UPDATE. 2026;32(2):129-153

  The road to restore male fertility using in vitro-derived germ cells

  Macedo T; Alves-Lopes JP
• Article: PEDIATRIC HEMATOLOGY AND ONCOLOGY. 2026;43(2):89-102

  Long-Term Health Outcomes in Male Survivors of Childhood Cancer After Hematopoietic Stem Cell Transplantation: A Registry-Based Study

  Koskela M; Korhonen M; Jahnukainen K
• Article: JOURNAL OF CANCER SURVIVORSHIP. 2026;20(1):12-19

  A 12-year overview of fertility preservation practice in Nordic pediatric oncology centers

  Asadi-Azarbaijani B; Oskam IC; Jahnukainen K
• Article: PEDIATRIC HEMATOLOGY AND ONCOLOGY. 2026;43(1):9-20

  Sexual activity in young adult survivors of childhood cancer: a population-based study

  Fagerkvist K; Haavisto A; Jahnukainen K; Axelsson O; Lampic C; Wettergren L
• Article: JOURNAL OF OVARIAN RESEARCH. 2025;19(1):15

  Micro-CT and machine learning: a high-throughput alternative to histology for follicle reserve assessment in cryopreserved ovarian tissue

  Knuus K; Nguyen M; Hannula M; Hassan J; Otala M; Tuuri T; Lundin K; Lahtinen A; Damdimopoulou P; Hyttinen J; Jahnukainen K
• Article: JCO ONCOLOGY PRACTICE. 2025;21(11):1681-1688

  Guidelines, Counseling Practices, and Fertility Preservation Options for Childhood Cancer Patients in the Nordic-Baltic Region

  Grubliauskaite M; Gudleviciene Z; Oskam IC; Asadi-Azarbaijani B; Jahnukainen K
• Article: CLINICAL EPIGENETICS. 2025;17(1):154

  Epigenetic risk stratification in juvenile myelomonocytic leukemia by targeted methylation analysis of the BMP4 locus.

  Ghanjati F; Heck A; Lebrecht D; Nöllke P; Andresen F; Rotari N; Schoof M; Schönung M; Lipka DB; Dworzak M; De Moerloose B; Sukova M; Hasle H; Jahnukainen K; Malone A; Masetti R; Buechner J; Ussowicz M; Catala A; Turkiewicz D; de Haas V; Schmugge M; Erlacher M; Niemeyer CM; Flotho C
• Journal article: MOLECULAR HUMAN REPRODUCTION. 2025;31(4):gaaf055

  An Nlrp5-null mutation leads to attenuated de novo methylation in oocytes, accompanied by a significant reduction in DNMT3L

  Nic Aodha L; Pokhilko A; Rosen LU; Galatidou S; Walewska E; Belton C; Galvao A; Okkenhaug H; Yu L; Nakhuda A; Mansfield B; Khan S; Oxley D; Barragan M; Kelsey G
• Article: BRITISH JOURNAL OF HAEMATOLOGY. 2025;207(4):1454-1463

  Characteristics and prognosis of paediatric normal karyotype acute myeloid leukaemia: A NOPHO-DBH AML study.

  Herlin MK; Kjeldsen E; Abrahamsson J; Arad-Cohen N; Cheuk D; De Moerloose B; Jahnukainen K; Jónsson ÓG; Kaspers GJL; Kovalova Z; Navarro JMF; Noren-Nyström U; Palle J; Pasaulienė R; Saks K; Zeller B; Holmfeldt L; Hasle H; Juul-Dam KL
• Article: BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY. 2025;102:102638

  Is the time right for transplanting immature testicular tissue or cells to restore male fertility? Expert perspectives on clinical implementation of autotransplantation of cryopreserved testicular tissue or cells for fertility restoration

  Safrai M; Goossens E; Mitchell RT; Orwig KE; Mulderf CL; van Pelt AMM; Gookh DA; Feraillej A; Delgouffe E; Ginsberg JP; Stukenborg J-B; Duffin K; Jahnukainen K; Andersen CY; van de Wetering MD; Rimmer MP; Barraud-Lange V; Neuhaus N; Lane S; Sadri-Ardekani H; Rives N; Wyns C
• Review: DEVELOPMENT. 2025;152(17):dev204968

  Emerging principles and models of human primordial germ cell development

  Ramakrishna NB; Alves-Lopes JP; Gruhn WH
• Article: ANDROLOGY. 2025;13(6):1575-1591

  Imatinib decreases germ cell survival and germline stem cell proliferation in rodent testis ex vivo and in vitro

  Eggert A; Laasanen S; Nurmio M; Wahlgren A; Jahnukainen K; Eerola K; Nieminen M; Olotu O; Kotaja N; Makela J-A; Toppari J
• Article: HUMAN REPRODUCTION. 2025;40(8):1467-1475

  Early transcriptional states of spermatogonia and marker expressions in the prepubertal human testis following chemotherapy-induced depletion

  Omar HB; Stevens J; Haavisto A; Cui Y; Harteveld F; Yang Y; Bjarnason R; Romerius P; Sundin M; Nystroem UN; Langenskioeld C; Vogt H; Frisk P; Vepsaelaeinen K; Petersen C; Cui L; Guo J; Jahnukainen K; Stukenborg J-B
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Medarbetare och kontakt

Gruppledare

• 

  João Pedro Alves-Lopes

  Biträdande Lektor

  E-postadress joao.pedro.lopes@ki.se

Alla medarbetare i gruppen

• Anu Haavisto

  Anknuten till Forskning

  E-postadress anu.haavisto@ki.se
• 

  Kirsi Jahnukainen

  Anknuten till Undervisning/Handledning | Docent

  E-postadress kirsi.jahnukainen@ki.se
• Antti Risto Mikael Koskela

  Postdoktor

  E-postadress mikael.koskela@ki.se
• 

  Tiago Macedo

  E-postadress tiago.macedo@ki.se
• 

  Leah Nic Aodha

  Postdoktor

  E-postadress leah.nic.aodha@ki.se
• Cecilia Petersen

  Anknuten till Undervisning/Handledning

  E-postadress cecilia.petersen@ki.se
• Xiaoyan Wang

  Anknuten till Forskning

  E-postadress xiaoyan.wang@ki.se

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