3D-EM Core Facility - Related publications

Structural basis of frizzled 7 activation and allosteric regulation.
Bous J, Kinsolving J, Grätz L, Scharf MM, Voss JH, Selcuk B, Adebali O, Schulte G
Nat Commun 2024 Aug;15(1):7422 

Re-engineered guide RNA enables DNA loops and contacts modulating repression in E. coli.
Yang Y, Rocamonde-Lago I, Shen B, Berzina I, Zipf J, Högberg B
Nucleic Acids Res 2024 Aug;52(15):9328-9339

 A DNA robotic switch with regulated autonomous display of cytotoxic ligand nanopatterns.
Wang Y, Baars I, Berzina I, Rocamonde-Lago I, Shen B, Yang Y, Lolaico M, Waldvogel J, Smyrlaki I, Zhu K, Harris RA, Högberg B
Nat Nanotechnol 2024 Jul;():

Prevention of uropathogenic E. coli biofilm formation by hydrophobic nanoparticle coatings on polymeric substrates.
Dietl S, Merkl P, Sotiriou GA
RSC Appl Interfaces 2024 Jul;1(4):667-670

Silver/gold nanoalloy implant coatings with antibiofilm activity via pH-triggered silver ion release.
Geissel FJ, Platania V, Tsikourkitoudi V, Larsson JV, Thersleff T, Chatzinikolaidou M, Sotiriou GA
Chem Commun (Camb) 2024 Jul;60(60):7729-7732

Transdermal Sensing of Enzyme Biomarker Enabled by Chemo-Responsive Probe-Modified Epidermal Microneedle Patch in Human Skin Tissue.
Poursharifi N, Hassanpouramiri M, Zink A, Ucuncu M, Parlak O
Adv Mater 2024 Jul;36(30):e2403758

Paper-based colorimetric hyperammonemia sensing by controlled oxidation of plasmonic silver nanoparticles.
Merkl P, Sotiriou GA
Nanoscale Adv 2024 May;6(10):2586-2593

GTPBP8 plays a role in mitoribosome formation in human mitochondria.
Cipullo M, Valentín Gesé G, Gopalakrishna S, Krueger A, Lobo V, Pirozhkova MA, Marks J, Páleníková P, Shiriaev D, Liu Y, Misic J, Cai Y, Nguyen MD, Abdelbagi A, Li X, Minczuk M, Hafner M, Benhalevy D, Sarshad AA, Atanassov I, Hällberg BM, Rorbach J
Nat Commun 2024 Jul;15(1):5664

Multi-compartmental diversification of neutralizing antibody lineages dissected in SARS-CoV-2 spike-immunized macaques.
Mandolesi M, Das H, de Vries L, Yang Y, Kim C, Dhinakaran M, Castro Dopico X, Fischbach J, Kim S, Guryleva MV, Àdori M, Chernyshev M, Stålmarck A, Hanke L, McInerney GM, Sheward DJ, Corcoran M, Hällberg BM, Murrell B, Karlsson Hedestam GB
Nat Commun 2024 Jul;15(1):6338

Dynamics of the Herpes simplex virus DNA polymerase holoenzyme during DNA synthesis and proof-reading revealed by Cryo-EM.
Gustavsson E, Grünewald K, Elias P, Hällberg BM
Nucleic Acids Res 2024 Jul;52(12):7292-7304

Structural basis of broad SARS-CoV-2 cross-neutralization by affinity-matured public antibodies.
Sheward DJ, Pushparaj P, Das H, Greaney AJ, Kim C, Kim S, Hanke L, Hyllner E, Dyrdak R, Lee J, Dopico XC, Dosenovic P, Peacock TP, McInerney GM, Albert J, Corcoran M, Bloom JD, Murrell B, Karlsson Hedestam GB, Hällberg BM
Cell Rep Med 2024 Jun;5(6):101577

Structural and Functional Characterization of a Gene Cluster Responsible for Deglycosylation of C-glucosyl Flavonoids and Xanthonoids by Deinococcus aerius.
Furlanetto V, Kalyani DC, Kostelac A, Puc J, Haltrich D, Hällberg BM, Divne C
J Mol Biol 2024 Mar;436(9):168547

Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD7.
Kinsolving J, Bous J, Kozielewicz P, Košenina S, Shekhani R, Grätz L, Masuyer G, Wang Y, Stenmark P, Dong M, Schulte G
Cell Rep 2024 Feb;43(2):113727

Laboratory Liquid-Jet X-ray Microscopy and X-ray Fluorescence Imaging for Biomedical Applications.
Arsana KGY, Saladino GM, Brodin B, Toprak MS, Hertz HM
Int J Mol Sci 2024 Jan;25(2):

Soluble and multivalent Jag1 DNA origami nanopatterns activate Notch without pulling force.
Smyrlaki I, Fördős F, Rocamonde-Lago I, Wang Y, Shen B, Lentini A, Luca VC, Reinius B, Teixeira AI, Högberg B
Nat Commun 2024 Jan;15(1):465

Wireframe DNA Origami for the Cellular Delivery of Platinum(II)-Based Drugs.
De Luca E, Wang Y, Baars I, De Castro F, Lolaico M, Migoni D, Ducani C, Benedetti M, Högberg B, Fanizzi FP
Int J Mol Sci 2023 Nov;24(23):

Democratizing robust SERS nano-sensors for food safety diagnostics
Haipeng Li, Elodie Dumont, Roman Slipets, Thomas Thersleff, Anja Boisen, Georgios A. Sotiriou
Chemical Engineering Journal Volume 470, 15 August 2023

Mass Spectrometry of RNA-Binding Proteins during Liquid-Liquid Phase Separation Reveals Distinct Assembly Mechanisms and Droplet Architectures.
Sahin C, Motso A, Gu X, Feyrer H, Lama D, Arndt T, Rising A, Gese GV, Hällberg BM, Marklund EG, Schafer NP, Petzold K, Teilum K, Wolynes PG, Landreh M
J Am Chem Soc 2023 May;():

Computer-Aided Design of A-Trail Routed Wireframe DNA Nanostructures with Square Lattice Edges.
Lolaico M, Blokhuizen S, Shen B, Wang Y, Högberg B
ACS Nano 2023 Apr;17(7):6565-6574

Hybrid microneedle arrays for antibiotic and near-IR photothermal synergistic antimicrobial effect against Methicillin-Resistant Staphylococcus aureus.
Ziesmer J, Larsson JV, Sotiriou GA
Chem Eng J 2023 Apr;462():142127

A "grappling hook" interaction connects self-assembly and chaperone activity of Nucleophosmin 1.
Saluri M, Leppert A, Gese GV, Sahin C, Lama D, Kaldmäe M, Chen G, Elofsson A, Allison TM, Arsenian-Henriksson M, Johansson J, Lane DP, Hällberg BM, Landreh M
PNAS Nexus 2023 Feb;2(2):pgac303

Solid Phase Synthesis of DNA Nanostructures in Heavy Liquid.
Smyrlaki I, Shaw A, Yang Y, Shen B, Högberg B
Small 2023 Jan;19(4):e2204513

Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies.
Pushparaj P, Nicoletto A, Sheward DJ, Das H, Castro Dopico X, Perez Vidakovics L, Hanke L, Chernyshev M, Narang S, Kim S, Fischbach J, Ekström S, McInerney G, Hällberg BM, Murrell B, Corcoran M, Karlsson Hedestam GB
Immunity 2023 Jan;56(1):193-206.e7

Nanostructured Ag‐Bioglass Implant Coatings with Antibacterial and Osteogenic Activity.
Felix J. Geissel, Varvara Platania, Niccoló DeBerardinis, Charlotte Skjöldebrand, Georgios N. Belibasakis, Cecilia Persson, Gry Hulsart-Billström, Maria Chatzinikolaidou, Georgios A. Sotiriou
Adv Mater Interfaces 2023 Jan Vol.10(3)

Highly Efficient Near-IR Photothermal Microneedles with Flame-Made Plasmonic Nanoaggregates for Reduced Intradermal Nanoparticle Deposition.
Ziesmer J, Sondén I, Thersleff T, Sotiriou GA
Adv Mater Interfaces 2022 Dec;9(34):

Algal photosystem I dimer and high-resolution model of PSI-plastocyanin complex.
Naschberger A, Mosebach L, Tobiasson V, Kuhlgert S, Scholz M, Perez-Boerema A, Ho TTH, Vidal-Meireles A, Takahashi Y, Hippler M, Amunts A
Nat Plants 2022 Oct;():

SERS Hotspot Engineering by Aerosol Self-Assembly of Plasmonic Ag Nanoaggregates with Tunable Interparticle Distance.
Li H, Merkl P, Sommertune J, Thersleff T, Sotiriou GA
Adv Sci (Weinh) 2022 Aug;9(22):e2201133

Non-coding 7S RNA inhibits transcription via mitochondrial RNA polymerase dimerization.
Zhu X, Xie X, Das H, Tan BG, Shi Y, Al-Behadili A, Peter B, Motori E, Valenzuela S, Posse V, Gustafsson CM, Hällberg BM, Falkenberg M
Cell 2022 06;185(13):2309-2323.e24

A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo.
Hanke L, Das H, Sheward DJ, Perez Vidakovics L, Urgard E, Moliner-Morro A, Kim C, Karl V, Pankow A, Smith NL, Porebski B, Fernandez-Capetillo O, Sezgin E, Pedersen GK, Coquet JM, Hällberg BM, Murrell B, McInerney GM
Nat Commun 2022 01;13(1):155

Black Charcoal for Green and Scalable Wooden Electrodes for Supercapabatteries
Liu, L., Masich, S., Björk, E., Solin, N. & Inganas, O.
Black Charcoal for Green and Scalable Wooden Electrodes for Supercapabatteries. Energy Technology 10.1002/ente.202101072. (2022).

Structural basis for late maturation steps of the human mitoribosomal large subunit
Cipullo M, Gese GV, Khawaja A, Hällberg BM*, Rorbach J*.
Nature Communications, June 16, 2021, doi: 10.1038/s41467-021-23617-8.

Plasmonic Coupling in Silver Nanoparticle Aggregates and Their Polymer Composite Films for Near-Infrared Photothermal Biofilm Eradication.
Merkl P, Zhou S, Zaganiaris A, Shahata M, Eleftheraki A, Thersleff T, Sotiriou GA
ACS Appl Nano Mater 2021 May;4(5):5330-5339

Antiviral Activity of Silver, Copper Oxide and Zinc Oxide Nanoparticle Coatings against SARS-CoV-2.
Merkl P, Long S, McInerney GM, Sotiriou GA
Nanomaterials (Basel) 2021 May;11(5):

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.
Koenig PA, Das H, Liu H, Kümmerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Tödtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hällberg BM, Wu NC, Schmidt FI
Science 2021 02;371(6530):

Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch.
Lehmann LC, Bacic L, Hewitt G, Brackmann K, Sabantsev A, Gaullier G, Pytharopoulou S, Degliesposti G, Okkenhaug H, Tan S, Costa A, Skehel JM, Boulton SJ, Deindl S
Cell Rep 2020 Dec;33(12):108529

Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2.
Custódio TF, Das H, Sheward DJ, Hanke L, Pazicky S, Pieprzyk J, et al
Nat Commun 2020 11;11(1):5588

A latent lineage potential in resident neural stem cells enables spinal cord repair.
Llorens-Bobadilla E, Chell JM, Le Merre P, Wu Y, Zamboni M, Bergenstråhle J, et al
Science 2020 10;370(6512):

An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.
Hanke L, Vidakovics Perez L, Sheward DJ, Das H, Schulte T, Moliner-Morro A, et al
Nat Commun 2020 09;11(1):4420