Tumor Immunology and Immunotherapy Group – Dhifaf Sarhan

Our mission is to develop novel immunotherapies for cancer. Our research focuses on understanding the mechanisms that contribute to an immune suppressive tumor microenvironment (TME) in treatment resistant cancers biased by sex immune dimorphism and utilizing targeted therapies to reshape the immune regulatory TME. We also investigate innate immune memory mechanisms to equip Natural killer cells (NK cells) with immune memory features against solid tumors.

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Publications
Funding
Members and contact

Publications

Selected publications

Article: CANCER RESEARCH. 2021;81(4):956-967

Targeting MARCO and IL37R on Immunosuppressive Macrophages in Lung Cancer Blocks Regulatory T Cells and Supports Cytotoxic Lymphocyte Function.

La Fleur L; Botling J; He F; Pelicano C; Zhou C; He C; Palano G; Mezheyeuski A; Micke P; Ravetch JV; Karlsson MCI; Sarhan D
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(50):32005-32016

Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells.

Eisinger S; Sarhan D; Boura VF; Ibarlucea-Benitez I; Tyystjärvi S; Oliynyk G; Arsenian-Henriksson M; Lane D; Wikström SL; Kiessling R; Virgilio T; Gonzalez SF; Kaczynska D; Kanatani S; Daskalaki E; Wheelock CE; Sedimbi S; Chambers BJ; Ravetch JV; Karlsson MCI
Article: JCI INSIGHT. 2020;5(5):130155

Mesenchymal stromal cells shape the MDS microenvironment by inducing suppressive monocytes that dampen NK cell function.

Sarhan D; Wang J; Sunil Arvindam U; Hallstrom C; Verneris MR; Grzywacz B; Warlick E; Blazar BR; Miller JS
Article: CANCER IMMUNOLOGY RESEARCH. 2018;6(7):766-775

Adaptive NK Cells Resist Regulatory T-cell Suppression Driven by IL37.

Sarhan D; Hippen KL; Lemire A; Hying S; Luo X; Lenvik T; Curtsinger J; Davis Z; Zhang B; Cooley S; Cichocki F; Blazar BR; Miller JS
Article: BLOOD ADVANCES. 2018;2(12):1459-1469

161533 TriKE stimulates NK-cell function to overcome myeloid-derived suppressor cells in MDS.

Sarhan D; Brandt L; Felices M; Guldevall K; Lenvik T; Hinderlie P; Curtsinger J; Warlick E; Spellman SR; Blazar BR; Weisdorf DJ; Cooley S; Vallera DA; Önfelt B; Miller JS

Funding

Members and contact

Group leader

Dhifaf Sarhan
Assistant Professor | Docent

E-mail dhifaf.sarhan@ki.se

All members of the group

Chizoba Ejuama
Other

E-mail chizoba.ejuama@ki.se
Leon Heffinger
Affiliated to Research

E-mail leon.heffinger@ki.se
Styliani Ladomenou
Other

E-mail styliani.ladomenou@ki.se
Pernilla Lång
Assistant Senior Lecturer

Telephone +46852486910

E-mail pernilla.lang@ki.se
Nerea Martín Almazán
Phd Student

E-mail nerea.martin.almazan@ki.se
Dhifaf Sarhan
Assistant Professor | Docent

E-mail dhifaf.sarhan@ki.se
Yizhe Sun
Phd Student

E-mail yizhe.sun@ki.se

Tumor Immunology and Immunotherapy Group – Dhifaf Sarhan

Research line I: Studies of sexual immune dimorphism in the TM

Research line II: aNK cells in solid tumors

News

Immune cell gives possible explanation for sex differences in pancreatic cancer

Differences in tumor microenvironment between female and male patients with pancreatic cancer

Research uncovers a possible explanation for sex differences in pancreatic cancer