Pernilla Lång

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About me

I am an assistant lecturer and researcher at the Division of Pathology, Department of Laboratory Medicine. In addition to my teaching and research responsibilities, since May 2023, I have taken on the role of Program Director for both the Biomedical Analyst program and the Master's program in Biomedical Laboratory Science.

Research

My research conserns the multifaced protein tartrate resistant acid phosphatase (TRAP) and its function in different conditions such as immune regulation and cancer development.

Teaching

My teaching portfolio spans a diverse range of subjects, encompassing both theoretical and practical aspects of cell and molecular biology, alongside general pathology, scientific methodology, and biostatistics. Additionally, I cover essential topics in chemistry and biochemistry, as well as immunology.

Beyond the hard sciences, I am also committed to teaching project management, communication, and leadership skills.

Central to my teaching philosophy is the belief in active training over passive learning. My goal is to empower students to become independent thinkers and problem-solvers, equipping them with the knowledge and skills they need to thrive in their future careers.

Articles

Article: IMMUNOLOGY. 2024;171(4):583-594
Macrophage expressed tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis progression
Bergwik J; Bhongir RKV; Padra M; Adler A; Olm F; Lang P; Lindstedt S; Andersson G; Egesten A; Tanner L
Article: BONE REPORTS. 2023;19:101697
RANKL-dependent osteoclast differentiation and gene expression in bone marrow-derived cells from adult mice is sexually dimorphic
Desai S; Lang P; Nareoja T; Windahl SH; Andersson G
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:1079775
Tartrate resistant acid phosphatase 5 (TRAP5) mediates immune cell recruitment in a murine model of pulmonary bacterial infection
Tanner L; Bergwik J; Bhongir RKV; Puthia M; Lang P; Ali MN; Welinder C; Onnerfjord P; Erjefalt JS; Palmberg L; Andersson G; Egesten A
Article: FEBS LETTERS. 2021;595(20):2616-2627
Tartrate-resistant acid phosphatase type 5/ACP5 promotes cell cycle entry of 3T3-L1 preadipocytes by increasing IGF-1/Akt signaling
Lang P; Patlaka C; Andersson G
Article: EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY. 2020;25(5):1387-1397
Intensive weight gain therapy in patients with anorexia nervosa results in improved serum tartrate-resistant acid phosphatase (TRAP) 5a and 5b isoform protein levels
Patlaka C; Tubic B; Lang P; Paulie S; Swolin-Eide D; Magnusson P; Andersson G
Article: CALCIFIED TISSUE INTERNATIONAL. 2020;106(2):194-207
A Novel Sandwich ELISA for Tartrate-Resistant Acid Phosphatase 5a and 5b Protein Reveals that Both Isoforms are Secreted by Differentiating Osteoclasts and Correlate to the Type I Collagen Degradation Marker CTX-I In Vivo and In Vitro
Mira-Pascual L; Patlaka C; Desai S; Paulie S; Nareoja T; Lang P; Andersson G
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(2):E538-538
A Sub-Clone of RAW264.7-Cells Form Osteoclast-Like Cells Capable of Bone Resorption Faster than Parental RAW264.7 through Increased De Novo Expression and Nuclear Translocation of NFATc1
Mira-Pascual L; Tran AN; Andersson G; Nareoja T; Lang P
Article: JOURNAL OF CELLULAR PHYSIOLOGY. 2019;234(9):16503-16516
Cyclin-dependent kinase 8/19 inhibition suppresses osteoclastogenesis by downregulating RANK and promotes osteoblast mineralization and cancellous bone healing
Amirhosseini M; Bernhardsson M; Lang P; Andersson G; Flygare J; Fahlgren A
Article: BIOMARKERS. 2017;22(8):764-774
The adipokine tartrate-resistant acid phosphatase 5a in serum correlates to adipose tissue expansion in obesity
Patlaka C; Pascual LM; Paulie S; Henriksson A-F; Arner P; Lang P; Andersson G
Article: PLOS ONE. 2017;12(8):e0182904
Increased amount of phosphorylated proinflammatory osteopontin in rheumatoid arthritis synovia is associated to decreased tartrate-resistant acid phosphatase 5B/5A ratio
Luukkonen J; Pascual LM; Patlaka C; Lang P; Turunen S; Halleen J; Nousiainen T; Valkealahti M; Tuukkanen J; Andersson G; Lehenkari P
Journal article: BONE ABSTRACTS. 2016
RAW264.7 subclones - an in vitro model for osteoclast heterogeneity?
Mira-Pascual L; Lang P; Andersson G
Journal article: BONE ABSTRACTS. 2016
Development of a novel sandwich ELISA to quantify human Tartrate Resistant Acid Phosphatase (TRAP) isoforms 5a and 5b protein in one and the same sample
Patlaka C; Mira-Pascual L; Paulie S; Lang P; Andersson G
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2014;454(3):446-452
The growth factor-like adipokine tartrate-resistant acid phosphatase 5a interacts with the rod G3 domain of adipocyte-produced nidogen-2
Patlaka C; Mai HA; Lang P; Andersson G
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2014;1843(3):495-507
Caveolae-mediated endocytosis of the glucosaminoglycan-interacting adipokine tartrate resistant acid phosphatase 5a in adipocyte progenitor lineage cells
Patlaka C; Becker H; Norgard M; Paulie S; Nordvall-Bodell A; Lang P; Andersson G
Article: DIABETOLOGIA. 2013;56(8):1792-1801
Semaphorin 3C is a novel adipokine linked to extracellular matrix composition
Mejhert N; Wilfling F; Esteve D; Galitzky J; Pellegrinelli V; Kolditz C-I; Viguerie N; Tordjman J; Naslund E; Trayhurn P; Lacasa D; Dahlman I; Stich V; Lang P; Langin D; Bouloumie A; Clement K; Ryden M
Article: CELLS TISSUES ORGANS. 2012;196(1):68-81
Transgenic Overexpression of Tartrate-Resistant Acid Phosphatase Is Associated with Induction of Osteoblast Gene Expression and Increased Cortical Bone Mineral Content and Density
Gradin P; Hollberg K; Cassady AI; Lang P; Andersson G
Article: INTERNATIONAL JOURNAL OF OBESITY. 2011;35(12):1502-1510
Expression and secretion of the novel adipokine tartrate-resistant acid phosphatase from adipose tissues of obese and lean women
Lang P; Zakaroff-Girard A; Wahlen K; Andersson J; Olsson T; Bambace C; Jocken J; Bouloumie A; Andersson G; Arner P
Article: HISTOCHEMISTRY AND CELL BIOLOGY. 2009;132(6):599-612
Induction and cellular expression of tartrate resistant acid phosphatase during dextran sodium sulphate induced colitis in rats
Lang P; Lange S; Delbro D; Andersson G
Article: PLOS ONE. 2008;3(3):e1713
Monomeric Tartrate Resistant Acid Phosphatase Induces Insulin Sensitive Obesity
Lang P; van Harmelen V; Ryden M; Kaaman M; Parini P; Carneheim C; Cassady AI; Hume DA; Andersson G; Arner P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(31):28370-28381
Proteolytic excision of a repressive loop domain in tartrate-resistant acid phosphatase by cathepsin K in osteoclasts
Ljusberg J; Wang YL; Lång P; Norgård M; Dodds R; Hultenby K; Ek-Rylander B; Andersson G
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2005;62(7-8):905-918
Differential expression of monomeric and proteolytically processed forms of tartrate-resistant acid phosphatase in rat tissues
Lång P; Andersson G
Article: NATURE CELL BIOLOGY. 2004;6(6):523-531
Myosin-X provides a motor-based link between integrins and the cytoskeleton
Zhang HQ; Berg JS; Li ZL; Wang YL; Lång P; Sousa AD; Bhaskar A; Cheney RE; Strömblad S
Article: JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY. 2001;49(3):379-396
Expression and distribution of tartrate-resistant purple acid phosphatase in the rat nervous system
Lång P; Schultzberg M; Andersson G
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All other publications

Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2019;199:a4519
Effects of Cigarette Smoke Exposure on Tartrate-Resistant Acid Phosphatase Expression in Murine Lung Tissue
van der Veen A; Lang P; de Jager MH; Andersson G; Melgert BN
Conference publication: FEBS JOURNAL. 2012;279:544
TRAP 5a interacts with cells of mesenchymal lineage and affects their differentiation
Patlaka C; Mai HA; Nordvall-Bodell A; Lang P; Andersson G
Doctoral thesis: 2007
Tartrate resistant acid phosphatase in the immune and nervous system : distribution and pathophysiological implications
Lång, Pernilla
Published conference paper: JOURNAL OF BONE AND MINERAL RESEARCH. 2003;18(10):1912-1915
TRACP as an osteopontin phosphatase
Andersson G; Ek-Rylander B; Hollberg K; Ljusberg-Sjölander J; Lång P; Norgård M; Wang YL; Zhang SJ
Conference publication: JOURNAL OF BONE AND MINERAL RESEARCH. 2000;15:S395
Cellular localization of tartrate resistant acid phosphatase and osteopontin in rat lymphatic organs.
Lång P; Andersson G
Conference publication: JOURNAL OF BONE AND MINERAL RESEARCH. 1999;14:S486
Expression and distribution of tartrate-resistant purple acid phosphatase in the rat nervous system.
Lång P; Schultzberg M; Andersson G

Employments

Assistant Senior Lecturer, Department of Laboratory Medicine, Karolinska Institutet, 2022-

Degrees and Education

Doctor Of Philosophy, Department of Laboratory Medicine, Karolinska Institutet, 2007
Bachelor Of Medical Science, Karolinska Institutet, 1998

Leadership and responsibility assignments

Responsible for a study programme, Biomedical analyst program, Laboratory Medicine, Karolinska Institutet, 2023-
Responsible for a study programme, Masterprogram in biomedical laboratory science, Laboratory Medicine, Karolinska Institutet, 2023-
Project leader, Development of new curriculum for biomedicial analyst program, Laboratory Medicine, Karolinska Institutet, 2021-2023

Supervisor

Laia Mira Pascual, Role of tartrate-resistant acid phosphatase in bone remodeling, https://openarchive.ki.se/xmlui/handle/10616/46930
Christina Patlaka, Tartrate resistant acid phosphatase 5a : a potential regulator of adipocyte cell number and differentiation in white adipose tissue, https://openarchive.ki.se/xmlui/handle/10616/44563
Suchita Desai, The role of mechanical loading, sex and TRAP/ACP5 on bone properties, https://openarchive.ki.se/xmlui/handle/10616/48681

About me

Research

Teaching

Articles

All other publications

Employments

Degrees and Education

Leadership and responsibility assignments

Supervisor

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