The Centre for Bioinformatics and Biostatistics (CBB) is a virtual centre located at the Karolinska Institutet’s (KI's) Campus Flemingsberg.
The Centre for Bioinformatics and Biostatistics (CBB) is a virtual centre located at the department of biosciences and nutrition at Karolinska Institutet’s (KI's) Campus Flemingsberg. The centre offers expertise and scientific networking opportunities to the pre-clinical and clinical research environment. Activities of the centre include mentoring for early-stage researchers (PhD students and postdocs), support for project planning and grant writing, as well as seminars and discussion groups around bioinformatics and biostatistics methods and their application to biomedical data.
History and relation to Clinicum
CBB is considered the Clinicum hub at Campus Flemingsberg. The Centre for Bioinformatics and Biostatistics (CBB) is in the startup phase since February 2021.
Relationship to KI core facilities
The centre keeps close relations with the existing KI core facilities and departments within the field. This includes close coordination to be able to refer requests appropriately to these core facilities. Redundancies of the services offered by existing KI core facilities and the services offered by CBB are kept a minimum.
CBB had a first information meeting on April 29th, 2021. A zoom recording from the meeting, as well as the presentation, can be found below.
Carsten DaubDirector CBB
Carsten Daub is an Associate Professor (“Docent” in the Swedish academic system) and group leader for the Clinical Transcriptomics research group at the Department of Biosciences and Nutrition at Karolinska Institutet. His bioinformatics expertise includes analysis of transcriptomics and epigenomics datasets, genome annotation and gene regulation.
Hannes HagströmCo-director CBB
Hannes Hagström is a consultant in Hepatology at the Karolinska University Hospital. He is also an associate professor and group leader for Hannes Hagström group (https://ki.se/en/medh/hagstrom-group) at Karolinska Institutet. His research is focused on clinical and epidemiological studies of liver diseases.
A steering group has been appointed by Dean KI South Maria Eriksdotter.
I hold a PhD in molecular and cellular biology but eventually transitioned into the field of bioinformatics. My initial focus encompassed the analysis of microarray gene expression studies and chromatin immunoprecipitation sequencing. Since then, I have acquired extensive experience in numerous applications where massively parallel sequencing can be applied. Specifically, my expertise extends to gene expression analysis (RNAseq), chromatin exploration (ChIPseq, ATACseq, RRBS), single-cell analysis, and extensive data visualization. I am proficient in R, which serves as the primary platform for conducting analyses. Furthermore, I have developed a robust understanding of Linux and bash scripting, essential for big data management and many analysis pipelines.
Due to my position at the BEA core facility, I have actively contributed to numerous projects spanning a broad spectrum of biological systems. This includes diverse areas such as cancer dynamics, developmental processes, and immune responses, encompassing a wide range of organisms from humans to viruses.
Davide is a PhD statistician with many years of experience in working with biological, epidemiological, genetic, and social data of different kind and in various contexts. During the last years his work has been focused on the analysis of immunological and survival data of patients after cell-therapy and allogeneic stem cell transplantation. His other main interest is education: teaching and mentoring students, and organizing seminars and workshops.
Ghada Nouairia is a computational biologist and a bioinformatician with experience in different computational methods (clustering, networks, phylogeny, etc.). She has also worked with a wide range of omics data including proteomics, transcriptomics, epigenomics and genomes.
Currently, her research is directed to clinical application for diagnosis and prognosis in oncology.
Henrike HäbelStatistician (currently on parental leave)
Henrike Häbel has a doctoral degree in mathematical statistics from Chalmers University of Technology and University of Gothenburg. Before joining Karolinska Institutet, she completed a post-doctoral fellowship at the Natural Resources Institute Finland. As part of the Medical Statistics Unit (Medstat), Department of Learning, Informatics, Management and Ethics (LIME) and the Centre for Bioinformatics and Biostatistics (CBB), Henrike mainly works with statistical consultation and teaching. Her main tasks include data management, survival and regression analysis in epidemiologic and population-based studies. Her research and teaching interests are in biostatistics, statistical epidemiology, spatial statistics and image analysis. Henrike has software experience in R, STATA, SAS and SPSS.
Laura Vossen-EngblomStatistician (currently on parental leave)
Laura is a biostatistician at the Karolinska University Hospital in Huddinge where her work involves data management, survival analysis and regression analysis of clinical trials and register-based studies. She works mainly in R and Stata, but is also familiar with SPSS, GraphPad and Statistica. For CBB, Laura mentors several (medical) PhD students and teaches biostatistics courses. Laura has a doctoral degree in biomedicine from Uppsala University, and a MSc and MEd (master in education) from the University of Groningen, the Netherlands.
Michael Ingre is a biostatistician at the Centre for Bioinformatics and Biostatistics (CBB) and the Department of Medicine (MedH) at Karolinska Institutet. He has earned a PhD in Psychology, and in his early research focused on stress, sleep, health, and working hours. Over the years Michael’s research intertest has expanded to include methodological research, meta-science, clinical research, and epidemiology.
Michael’s work primarily involves data management and transferring research questions, theories and hypotheses into statistical models that can be tested on data, as well as mentoring and teaching. He is experienced in using SPSS, Stata, and R, but prefer R.
Raphaela is a biostatistician at the Department of Medicine at Karolinska Institute in Huddinge. She holds a degree in engineering as well as a PhD in neuroscience. Prior to joining the Centre for Bioinformatics and Biostatistics (CBB), she held a position as a senior lecturer in epidemiology and infectious disease control at Södertörn University. Raphaela has experience as a scientific writer for various public and private institutions, including Springer-Nature, and has collaborated with the Cochrane Institute conducting evidence syntheses.
In her current role, Raphaela primarily utilizes R for her work. Her focus lies on statistical analyses for clinical trials and register-based studies, but she is also knowledgeable in pre-clinical methodology. At CBB, Raphaela is mentoring researchers, offering guidance in study planning, data management, and analysis.
Rickard Strandberg has a PhD in Biostatistics. His main expertise is in regression modelling and prediction, including linear models, longitudinal models, survival analysis, and multi-state models. He has experience working with cohorts and register-based data, and is adept with missing data.
As a researcher, Rickard currently works with clinical prediction models of chronic liver disease as a member of the Hagström research group at Karolinska Institutet Huddinge