Jonas Fuxe

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Articles

Article: JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA. 2023;28(1):25
TGFß1 Stimulates Lymphatic Endothelial Cells to Produce IL7 and IL15, Which Act as Chemotactic Factors for Breast Cancer Cells with Mesenchymal Properties
Giotopoulou N; Shi W; Parniewska MM; Sun W; Fuxe J
Article: SEMINARS IN CANCER BIOLOGY. 2022;86(Pt 3):166-179
Sex dimorphism in the tumor microenvironment - From bench to bedside and back
He F; Furones AR; Landegren N; Fuxe J; Sarhan D
Article: BIOLOGY. 2021;10(6):521
Nuclear Syndecan-1 Regulates Epithelial-Mesenchymal Plasticity in Tumor Cells
Kumar-Singh A; Parniewska MM; Giotopoulou N; Javadi J; Sun W; Szatmari T; Dobra K; Hjerpe A; Fuxe J
Article: BIOMOLECULES. 2020;10(12):E1621-1621
Different Regulation of Glut1 Expression and Glucose Uptake during the Induction and Chronic Stages of TGFβ1-Induced EMT in Breast Cancer Cells
Nilchian A; Giotopoulou N; Sun W; Fuxe J
Article: JOURNAL OF INFECTIOUS DISEASES. 2020;222(12):2041-2051
Induction of the Coxsackievirus and Adenovirus Receptor in Macrophages During the Formation of Atherosclerotic Plaques
Nilchian A; Plant E; Parniewska MM; Santiago A; Rossignoli A; Skogsberg J; Hedin U; Matic L; Fuxe J
Article: CELL DEATH AND DISEASE. 2020;11(10):920
Mutant CFTR Drives TWIST1 mediated epithelial-mesenchymal transition
Quaresma MC; Pankonien I; Clarke LA; Sousa LS; Silva IAL; Railean V; Dousova T; Fuxe J; Amaral MD
Article: BIOMOLECULES. 2020;10(7):E1034-1034
Mapping the Interactome of the Nuclear Heparan Sulfate Proteoglycan Syndecan-1 in Mesothelioma Cells
Kumar-Singh A; Shrinet J; Parniewska MM; Fuxe J; Dobra K; Hjerpe A
Article: CANCER RESEARCH. 2019;79(1):47-60
CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial-Mesenchymal Plasticity in Breast Cancer
Nilchian A; Johansson J; Ghalali A; Asanin ST; Santiago A; Rosencrantz O; Sollerbrant K; Vincent CT; Sund M; Stenius U; Fuxe J
Article: MOLECULAR ONCOLOGY. 2017;11(7):781-791
Epithelial-mesenchymal transition in cancer metastasis through the lymphatic system
Karlsson MC; Gonzalez SF; Welin J; Fuxe J
Article: SCIENTIFIC REPORTS. 2016;6:35712
Mesenchymal state of intimal cells may explain higher propensity to ascending aortic aneurysm in bicuspid aortic valves
Maleki S; Kjellqvist S; Paloschi V; Magne J; Branca RMM; Du L; Hultenby K; Petrini J; Fuxe J; Lehtio J; Franco-Cereceda A; Eriksson P; Bjorck HM
Article: CELL REPORTS. 2016;15(9):2000-2011
Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis
Georgoudaki A-M; Prokopec KE; Boura VF; Hellqvist E; Sohn S; Ostling J; Dahan R; Harris RA; Rantalainen M; Klevebring D; Sund M; Brage SE; Fuxe J; Rolny C; Li F; Ravetch JV; Karlsson MCI
Article: ONCOGENE. 2016;35(6):748-760
TGF-β1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis
Pang M-F; Georgoudaki A-M; Lambut L; Johansson J; Tabor V; Hagikura K; Jin Y; Jansson M; Alexander JS; Nelson CM; Jakobsson L; Betsholtz C; Sunds M; Karlsson MCI; Fuxe J
Article: BMJ OPEN DIABETES RESEARCH & CARE. 2016;4(1):e000219
Coxsackie-adenovirus receptor expression is enhanced in pancreas from patients with type 1 diabetes
Hodik M; Anagandula M; Fuxe J; Krogvold L; Dahl-Jorgensen K; Hyoty H; Sarmiento L; Frisk G
Article: AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2015;308(7):L658-L671
Pericytes contribute to airway remodeling in a mouse model of chronic allergic asthma
Johnson JR; Folestad E; Rowley JE; Noll EM; Walker SA; Lloyd CM; Rankin SM; Pietras K; Eriksson U; Fuxe J
Article: FRONTIERS IN ONCOLOGY. 2015;5:3
TGF-β1-induced epitheal-mesenchymal transition promotes monocyte/macrophage properties in breast cancer cells
Johansson J; Tabor V; Wikell A; Jalkanen S; Fuxe J
Article: DEVELOPMENT. 2014;141(23):4489-4499
Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain
Arnold TD; Niaudet C; Pang M-F; Siegenthaler J; Gaengel K; Jung B; Ferrero GM; Mukouyama Y-S; Fuxe J; Akhurst R; Betsholtz C; Sheppard D; Reichardt LF
Article: ONCOGENESIS. 2014;3(11):e125
C/EBPβ expression is an independent predictor of overall survival in breast cancer patients by MHCII/CD4-dependent mechanism of metastasis formation
Kurzejamska E; Johansson J; Jirstrom K; Prakash V; Ananthaseshan S; Boon L; Fuxe J; Religa P
Article: ONCOGENE. 2013;32(50):5614-5624
MiR-155-mediated loss of C/EBPβ shifts the TGF-β response from growth inhibition to epithelial-mesenchymal transition, invasion and metastasis in breast cancer
Johansson J; Berg T; Kurzejamska E; Pang M-F; Tabor V; Jansson M; Roswall P; Pietras K; Sund M; Religa P; Fuxe J
Article: CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY. 2013;4(6):e38
Human Enterovirus Species B in Ileocecal Crohn's Disease
Nystrom N; Berg T; Lundin E; Skog O; Hansson I; Frisk G; Juko-Pecirep I; Nilsson M; Gyllensten U; Finkel Y; Fuxe J; Wanders A
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2013;210(3):563-579
Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination
Anderberg C; Cunha SI; Zhai Z; Cortez E; Pardali E; Johnson JR; Franco M; Paez-Ribes M; Cordiner R; Fuxe J; Johansson BR; Goumans M-J; Casanovas O; ten Dijke P; Arthur HM; Pietras K
Journal article: JOURNAL OF CELL BIOLOGY. 2013;200(4):i10
Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination
Anderberg C; Cunha SI; Zhai Z; Cortez E; Pardali E; Johnson JR; Franco M; Páez-Ribes M; Cordiner R; Fuxe J; Johansson BR; Goumans M-J; Casanovas O; Dijke PT; Arthur HM; Pietras K
Article: CANCER BIOLOGY & THERAPY. 2012;13(14):1454-1462
Repeated cisplatin treatment can lead to a multiresistant tumor cell population with stem cell features and sensitivity to 3-bromopyruvate
Wintzell M; Lofstedt L; Johansson J; Pedersen AB; Fuxe J; Shoshan M
Article: DEVELOPMENTAL CELL. 2012;23(3):587-599
The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2
Gaengel K; Niaudet C; Hagikura K; Siemsen BL; Muhl L; Hofmann JJ; Ebarasi L; Nystrom S; Rymo S; Chen LL; Pang M-F; Jin Y; Raschperger E; Roswall P; Schulte D; Benedito R; Larsson J; Hellstrom M; Fuxe J; Uhlen P; Adams R; Jakobsson L; Majumdar A; Vestweber D; Uv A; Betsholtz C
Article: PLOS ONE. 2012;7(5):e37523
Essential Role of the Coxsackie - and Adenovirus Receptor (CAR) in Development of the Lymphatic System in Mice
Mirza M; Pang M-F; Zaini MA; Haiko P; Tammela T; Alitalo K; Philipson L; Fuxe J; Sollerbrant K
Article: AMERICAN JOURNAL OF PATHOLOGY. 2011;178(6):2897-2909
Pericyte Requirement for Anti-Leak Action of Angiopoietin-1 and Vascular Remodeling in Sustained Inflammation
Fuxe J; Tabruyn S; Colton K; Zaid H; Adams A; Baluk P; Lashnits E; Morisada T; Le T; O'Brien S; Epstein DM; Koh GY; McDonald DM
Article: PLOS ONE. 2011;6(1):e16175
Chronic Respiratory Aeroallergen Exposure in Mice Induces Epithelial-Mesenchymal Transition in the Large Airways
Johnson JR; Roos A; Berg T; Nord M; Fuxe J
Article: AMERICAN JOURNAL OF PATHOLOGY. 2010;177(6):3233-3243
Angiopoietin-2-Driven Vascular Remodeling in Airway Inflammation
Tabruyn SP; Colton K; Morisada T; Fuxe J; Wiegand SJ; Thurston G; Coyle AJ; Connor J; McDonald DM
Article: AMERICAN JOURNAL OF PATHOLOGY. 2010;176(4):2009-2018
Angiopoietin/Tie2 Signaling Transforms Capillaries into Venules Primed for Leukocyte Trafficking in Airway Inflammation
Fuxe J; Lashnits E; O'Brien S; Baluk P; Tabruyn SP; Kuhnert F; Kuo C; Thurston G; McDonald DM
Article: ONCOLOGY REPORTS. 2009;22(5):1063-1068
Estrogen receptor-β expression in human laryngeal carcinoma: Correlation with the expression of epithelial-mesenchymal transition specific biomarkers
Goulioumis AK; Fuxe J; Varakis J; Repanti M; Goumas P; Papadaki H
Article: NATURE CELL BIOLOGY. 2009;11(8):943-950
A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial-mesenchymal transition
Vincent T; Neve EPA; Johnson JR; Kukalev A; Rojo F; Albanell J; Pietras K; Virtanen I; Philipson L; Leopold PL; Crystal RG; Garcia de Herreros A; Moustakas A; Pettersson RF; Fuxe J
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2007;204(10):2349-2362
Functionally specialized junctions between endothelial cells of lymphatic vessels
Baluk P; Fuxe J; Hashizume H; Romano T; Lashnits E; Butz S; Vestweber D; Corada M; Molendini C; Dejana E; McDonald DM
Journal article: JOURNAL OF CELL BIOLOGY. 2007;178(7):i15
Functionally specialized junctions between endothelial cells of lymphatic vessels
Baluk P; Fuxe J; Hashizume H; Romano T; Lashnits E; Butz S; Vestweber D; Corada M; Molendini C; Dejana E; McDonald DM
Article: AMERICAN JOURNAL OF PATHOLOGY. 2006;169(6):2245-2253
Induction of neutrophil gelatinase-associated lipocalin in vascular injury via activation of nuclear factor-κB
Bu D-X; Hemdahl A-L; Gabrielsen A; Fuxe J; Zhu C; Eriksson P; Yan Z-Q
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(9):1566-1580
The coxsackie- and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis
Raschperger E; Thyberg J; Pettersson S; Philipson L; Fuxe J; Pettersson RF
Journal article: THE FASEB JOURNAL. 2006;20(5):a1148-a1149
Two types of endothelial junction in lymphatic vessels of mouse airways
Baluk P; Fuxe J; Hashizume H; Romano T; Turatti F; Dejana E; McDonald DM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(1):796-804
CLMP, a novel member of the CTX family and a new component of epithelial tight junctions
Raschperger E; Engstrom U; Pettersson RF; Fuxe J
Article: EXPERIMENTAL CELL RESEARCH. 2003;288(1):70-83
VIPL, a VIP36-like membrane protein with a putative function in the export of glycoproteins from the endoplasmic reticulum
Neve EPA; Svensson K; Fuxe J; Pettersson RF
Article: THE FASEB JOURNAL. 2003;17(2):764-766
Immortalization of bovine capillary endothelial cells by hTERT alone involves inactivation of endogenous p16^INK4A/pRb
Veitonmäki N; Fuxe J; Hultdin M; Roos G; Pattersson RF; Cao Y
Article: INTERNATIONAL JOURNAL OF CANCER. 2003;103(6):723-729
Expression of the coxsackie and adenovirus receptor in human astrocytic tumors and xenografts
Fuxe J; Liu L; Malin S; Philipson L; Collins VP; Pettersson RF
Article: CANCER GENE THERAPY. 2002;9(11):908-916
The combination of HSV-tk and endostatin gene therapy eradicates orthotopic human renal cell carcinomas in nude mice
Pulkkanen KJ; Laukkanen JM; Fuxe J; Kettunen MI; Rehn M; Kannasto JM; Parkkinen JJ; Kauppinen RA; Pettersson RF; Yla-Herttuala S
Article: MOLECULAR CANCER RESEARCH. 2000;11(7):373-384
Adenovirus-mediated overexpression of p15^INK4B inhibits human glioma cell growth, induces replicative senescence, and inhibits telomerase activity similarly to p16^INK4A
Fuxe J; Akusjärvi G; Goike HM; Roos G; Collins VP; Pettersson RF
Article: ONCOGENE. 2000;19(13):1724-1728
Translation of p15.5^INK4B, an N-terminally extended and fully active form of p15^INK4B, is initiated from an upstream GUG codon
Fuxe J; Raschperger E; Pettersson RF
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Preprint: BIORXIV. 2024
CXCR2-mediated recruitment of adaptive NK cells with NKG2C/HLA-E dependent antigen-specific memory enhances tumor killing in ovarian cancer
Sun Y; Rodgers-Furones A; Gultekin O; Khare S; Neo SY; Shi W; Galceran LM; Lam K-P; Dasgupta R; Fuxe J; Salehi S; Lehti K; Sarhan D
Preprint: RESEARCH SQUARE. 2023
TGF-beta1 stimulates lymphatic endothelial cells to produce IL-7 and IL-15, which act as chemotactic factors for breast cancer cells with EMT properties
Giotopoulou N; Parniewska MM; Shi W; Sun W; Fuxe J
Book chapter: HANDBOOK OF CANCER AND IMMUNOLOGY. 2023;p. 1-22
Epithelial-Mesenchymal Plasticity: A Link Between Inflammation and Cancer Metastasis
Parniewska MM; Shi W; Gatto F; Monzur S; Slager J; Fuxe J
Corrigendum: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2021;22(12):834
Guidelines and definitions for research on epithelial-mesenchymal transition (vol 21, pg 341, 2020)
Yang J; Antin P; Berx G; Blanpain C; Brabletz T; Bronner M; Campbell K; Cano A; Casanova J; Christofori G; Dedhar S; Derynck R; Ford HL; Fuxe J; Garcia de Herreros A; Goodall GJ; Hadjantonakis A-K; Huang RYJ; Kalcheim C; Kalluri R; Kang Y; Khew-Goodall Y; Levine H; Liu J; Longmore GD; Mani SA; Massague J; Mayor R; McClay D; Mostov KE; Newgreen DF; Nieto MA; Puisieux A; Runyan R; Savagner P; Stanger B; Stemmler MP; Takahashi Y; Takeichi M; Theveneau E; Thiery JP; Thompson EW; Weinberg RA; Williams ED; Xing J; Zhou BP; Sheng G
Review: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2020;21(6):341-352
Guidelines and definitions for research on epithelial-mesenchymal transition
Yang J; Antin P; Berx G; Blanpain C; Brabletz T; Bronner M; Campbell K; Cano A; Casanova J; Christofori G; Dedhar S; Derynck R; Ford HL; Fuxe J; Garcia de Herreros A; Goodall GJ; Hadjantonakis A-K; Huang RJY; Kalcheim C; Kalluri R; Kang Y; Khew-Goodall Y; Levine H; Liu J; Longmore GD; Mani SA; Massague J; Mayor R; McClay D; Mostov KE; Newgreen DF; Nieto MA; Puisieux A; Runyan R; Savagner P; Stanger B; Stemmler MP; Takahashi Y; Takeichi M; Theveneau E; Thiery JP; Thompson EW; Weinberg RA; Williams ED; Xing J; Zhou BP; Sheng G
Editorial comment: SEMINARS IN CANCER BIOLOGY. 2017;47:168-169
EMT, inflammation and metastasis
Vincent CT; Fuxe J
Book chapter: CANCER AND INFLAMMATION MECHANISMS. 2014;p. 23-39
Epithelial–Mesenchymal Transition: A Link between Cancer and Inflammation
Fuxe J; Karlsson MCI
Conference publication: ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. 2014;10:113
C/EBPB EXPRESSION IS AN INDEPENDENT PREDICTOR OF OVERALL SURVIVAL IN BREAST CANCER PATIENTS BY MHCII/CD4-DEPENDENT MECHANISM OF METASTASIS FORMATION
Kurzejamska E; Johansson J; Jirstrom K; Fuxe J; Religa P
Conference publication: THE FEBS JOURNAL. 2014;281:441-442
C/EBPβ expression is an independent predictor of overall survival in breast cancer patients by MHCII/CD4-dependent mechanism of metastasis formation
Kurzejamska E; Johansson J; Jirstrom K; Fuxe J; Religa P
Conference publication: ANGIOGENESIS. 2013;16(1):246-247
The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2
Gaengel K; Niaudet C; Hagikura K; Siemsen LB; Muhl L; Hofmann JJ; Ebarasi L; Nystrom S; Rymo S; Chen LL; Pang M-F; Jin Y; Raschperger E; Roswall P; Schulte D; Benedito R; Larsson J; Hellstrom M; Fuxe J; Uhlen P; Adams R; Jakobsson L; Majumdar A; Vestweber D; Uv A; Betsholtz C
Corrigendum: DEVELOPMENTAL CELL. 2012;23(6):1264
The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2 (vol 23, pg 587, 2012)
Gaengel K; Niaudet C; Hagikura K; Lavina B; Muhl L; Hofmann JJ; Ebarasi L; Nystroem S; Rymo S; Chen LL; Pang M-F; Jin Y; Raschperger E; Roswall P; Schulte D; Benedito R; Larsson J; Hellstroem M; Fuxe J; Uhlen P; Adams R; Jakobsson L; Majumdar A; Vestweber D; Uv A; Betsholtz C
Review: SEMINARS IN CANCER BIOLOGY. 2012;22(5-6):455-461
TGF-β-induced epithelial-mesenchymal transition: A link between cancer and inflammation
Fuxe J; Karlsson MCI
Conference publication: HISTOPATHOLOGY. 2012;61:28
C/EBPβ expression is an independent predictor of overall survival in breast cancer patients
Kurzejamska E; Jistrom K; Johansson J; Fuxe J; Religa P
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2011;183:a2874
Exosome Production And Trafficking To Lymph Nodes In A Mouse Model Of Chronic Allergic Asthma
Johnson J; Berg T; Torregrosa-Paredes P; Roos AB; Roswall P; Gabrielsson S; Fuxe J
Book chapter: CANCER STEM CELLS IN SOLID TUMORS: STEM CELL BIOLOGY AND REGENERATIVE MEDICINE. 2011;p. 243-256
The Epithelial-to-Mesenchymal Transition and Cancer Stem Cells
Fuxe J
Review: CELL CYCLE. 2010;9(12):2363-2374
Transcriptional crosstalk between TGFβ and stem cell pathways in tumor cell invasion Role of EMT promoting Smad complexes
Fuxe J; Vincent T; Garcia de Herreros A
Conference publication: 2010;:a3962
Pericytes And Vascular Smooth Muscle Cells Contribute To Airway Remodeling In Asthma
Johnson J; Folestad E; Eriksson U; Fuxe J
Thesis / dissertation: 2001
p16INK4A and p15INK4B in senescence, immortalization and cancer : gene transfer by adenovirus vectors
Fuxe, Jonas

Employments

Researcher, Department of Laboratory Medicine, Karolinska Institutet, 2020-

Degrees and Education

Docent, Karolinska Institutet, 2011
Doctor Of Philosophy, Department of Cell and Molecular Biology, Karolinska Institutet, 2001

Leadership and responsibility assignments

Head of department, Department of Laboratory Medicine, Karolinska Institutet, 2023-

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