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Elisabet Åkesson group

Human Neural Lesion, Repair and Rehab

Experimental research focus

Our interest is central nervous system lesions including spinal cord injury and treatment strategies to counteract neurodegenerative processes. We develop and utilize novel and unique model systems to evaluate specifically human spinal cord injury processes and repair strategies. In addition, we study host donor interactions including allogeneic responses to human neural cell therapy.

We perform organotypic spinal cord slice cultures as well as co-cultures including human neural cells, glial cell populations and/or human peripheral blood mononuclear cells to follow spinal cord injury processes and interactions between the injured spinal cord and potential donor neural cells.

We have the opportunity to compare human neural cells of various origins and from stem cell stage to more differentiated phenotypes concerning their immunocompetence and potential in neural cell therapy. In collaborations with others we utilize our cell and tissue slice systems to evaluate various biomaterials as support in regenerative medicine as well as develop new techniques in the expansion of neural cells for clinical application, such as the patented device Biogrid (PMID: 21850297). The laboratory is located in Neo at Karolinska Institutets South Campus in Huddinge and Bioclinicum Karolinska Institutets at North Campus in Solna.

Experimental research group members

Lektor, adjungerad

Elisabet Åkesson

Enhet: Åkesson
E-post: Elisabet.Akesson@ki.se

Forskarstuderande

Chenhong Lin

Enhet: Åkesson
E-post: chenhong.lin@ki.se

Biomedicinsk analytiker

Lena Holmberg

Enhet: Sundström
E-post: Lena.Holmberg@ki.se

Clinical research focus

We also perform clinical research in the field of nervous system lesions, neurodegenerative disorders, rehabilitation as well as primary care. We participate in the international clinical trials TransEuro and BOOSTB4.

Clinical rehabilitation and primary care research is ongoing at Stiftelsen Stockholms Sjukhem, R&D unit, Rehabilitation and primary care, where E Åkesson is clinical physician and coordinating R&D activities.

Examples of clinical research studies at Rehabilitation and Primary Care, Stockholms Sjukhem (SSH):

Sunnaas International Network Stroke Study, PI Kerstin Sjögren Fugl-Meyer with SSH as collaborative partner
Incidence, etiology and injury characteristics of traumatic SCI in Stockholm: A prospective, population based study, PI Kerstin Wahman, with SSH as collaborative partner
Make My Day: Value Based Client Centered and ICT-supported primary and secondary stroke prevention and rehabilitation after stroke, PI Eric Asaba, Susanne Guidetti, Kerstin Tham
Stroke, Rehabilitative training and tactile massage, PI Elisabet Åkesson
EFFECTS: Efficacy of fluoxetine, A randomized controlled trial in stroke, PI, Erik Lundström, KS/KI, SSH as collaborative partner with Ellinore Richardson in charge at SSH
Implementation of HiBalance training/ Förbättrad balans och fysisk aktivitet hos äldre - implementering av ett utmanande och progressivt träningsprogram, PI Erika Franzén
Oral screens in post stroke training: a randomized clinical trial, PI, Gunilla Sandborgh Englund, KI
Better In- Better out: Preoperativ träning för att minska risken för komplikationer och ge kortare vårdtider för sköra äldre efter operation, PI Elisabeth Rydwik, Erica Franzén, with SSH as collaborative partner
Etablering av långsiktigt stöd efter förvärvad hjärnskada: Implementering och erfarenheter av Hjärna Tillsammans, PI Lena von Koch, Malin Tistad, Susanne Guidetti, Elisabet Åkesson
DISKO: An interactive distance solution for stroke rehabilitation in the home setting, PIs E Åkesson & Susanne Palmcrants, Jörgen Borg at DS Rehab medicine

More information about Stockholm Sjukhem

Selected publications

A Combinatorial Approach to Induce Sensory Axon Regeneration into the Dorsal Root Avulsed Spinal Cord.
Hoeber J, König N, Trolle C, Lekholm E, Zhou C, Pankratova S, et al
Stem Cells Dev. 2017 07;26(14):1065-1077

Incidence, aetiology and injury characteristics of traumatic spinal cord injury in Stockholm, Sweden: A prospective, population-based update.
Joseph C, Andersson N, Bjelak S, Giesecke K, Hultling C, Nilsson Wikmar L, et al
J Rehabil Med 2017 May;49(5):431-436

Transplanted Human Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Do Not Promote Functional Recovery of Pharmacologically Immunosuppressed Mice With Contusion Spinal Cord Injury.
Pomeshchik Y, Puttonen K, Kidin I, Ruponen M, Lehtonen S, Malm T, et al
Cell Transplant 2015 ;24(9):1799-812

24412492

24034597

23416350

21850297

19383409

19181206

17610915

17610915

15748938

11476597

MHC antigen expression in human first trimester spinal cord with implications for clinical transplantation procedures.
Akesson E, Markling L, Kjaeldgaard A, Falci S, Ringdén O
J. Neuroimmunol. 2000 Nov;111(1-2):210-4

9454636

9421458

Dissertations

Ning Xu, 2015: Assessment of rat spinal cord injury models

Jia Liu, 2013: Host responses to human neural cell therapy in spinal cord injury

Jing-Hua Piao, 2007: Human neural precursor cells in spinal cord repair