Ph.D. Dissertations and Half-Time controls
For information about past Ph.D. dissertations, visit the Defended Ph.D. Theses section.
Half-time control for Madeleine Barrett
Developing glutathione peroxidase 1 and 4 inhibitors for the treatment of multi-drug-resistant cancers
My project focuses on developing novel and selective small molecule inhibitors of two antioxidant enzymes, glutathione peroxidase 1 and 4. I will discuss our high-throughput screening strategy, assay development, and the use of such inhibitors to deepen understanding of redox mechanisms in cancer cells. The seminar will present my progress to date and outline plans for the remainder of my doctoral education.
Date & time: August 22, 2025, at 15:00 CET
In-person location: Peter Reichard, Biomedicum
Zoom link: https://ki-se.zoom.us/j/67363178028?pwd=GEop0hqVyq0d9TTaDIcaBVLZpeXQvx.1
Committee members:
Brinton Seashore-Ludlow
Nikolas Herold
Ninib Baryawno
KI Supervisor: Elias Arnér
NIH Supervisor: Matthew Hall
Ph.D. Graduation Ceremony ("Promovering") for Radosveta Gencheva
We are proud to celebrate the Ph.D. graduation of Radosveta Gencheva. The ceremony took place on 16 June 2025 at the iconic Stockholm City Hall, marking a significant milestone in her academic journey.
Radosveta successfully defended her doctoral thesis titled “Mechanisms of Action of Thioredoxin Reductase Inhibitors in The Context of Cancer” on 6 December 2024 at Karolinska Institutet. Her research has contributed important insights into the molecular mechanisms of cancer therapy, advancing our understanding of redox biology and its therapeutic potential.
We warmly congratulate Dr. Gencheva on her achievement and wish her continued success in her scientific career!
Radosveta Gencheva's Ph.D. dissertation
Title: Mechanisms of Action of Thioredoxin Reductase Inhibitors in The Context of Cancer
Date: 06.12.2024, 9:00
Location: Nils Ringertz, Biomedicum, Solnavägen 9
Zoom link: https://ki-se.zoom.us/j/61398698098
Main supervisor:
Elias Arnér, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
Co-supervisors:
Qing Cheng, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
Volkan Sayin, Sahlgrenska Center for Cancer Research, University of Gothenburg
Opponent:
Yvonne Janssen-Heininger, Department of Pathology & Laboratory Medicine, University of Vermont
Examination Board:
Klas Wiman, Department of Oncology-Pathology, Karolinska Institutet
Mikael Lindström, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
Martin Högbom, Department of Biochemistry and Biophysics, Stockholm University
A digital copy of the Radosveta Gencheva's Thesis is available at KI Open Archive.
Radosveta Gencheva's Thesis Nailing Ceremony
Half-time control for Karoline Scholzen
Karoline Scholzen, a Ph.D. student in our group, will present her half-time seminar "Fluorogenic probes for single cell redox signalling" on March 28. Here's more information about the half-time seminar:
Date: 03/28/2024
Time: 9:00 am
Place: Biomedicum B0812
The half-time seminar will also be streamed via Zoom. You can join the seminar using the following link:
https://ki-se.zoom.us/j/67415389124
You can also download Karoline's half-time review here: