The Systems Virology Lab
The Systems Virology lab at Laboratory Medicine focuses on using systems biology and experimental approaches to understand the biology of host-pathogen interactions targeted towards the RNA viruses. The group aims to identify the components of the immune response that are required for natural immune protection and disease severity that can be translated into the future development of vaccine and antiviral strategies against emerging and re-emerging viruses.
Team Immuno-metabolic reprogramming during viral infection
We aim to understand metabolic reprogramming during viral infection using multi-omics system biology and experimental assays.
Lead: Ujjwal Neogi.
Team Innate immune responses during viral infections
We aim to understand common global interferon-stimulated gene (ISG) responses against different viruses can provide a novel avenue for viral antagonism.
Lead: Soham Gupta.
Group members
Selected publications
Funding and collaborators
Connection between metabolism and fatigue after Crimean-Congo Fever
A recent study published by researchers from Karolinska Institutet in collaboration with Sivas Cumhuriyet University, Turkey, sheds light on the connection between Crimean-Congo Haemorrhagic Fever Virus (CCHFV) infection and prolonged fatigue.
New insights into the cellular response to SARS-CoV-2 infection
The COVID-19 pandemic caused by the new coronavirus has created an unprecedented public health challenge globally. Little was known about how the infecting cells respond to the virus and how the virus hijacks the host cellular machinery. A study led by researchers at Karolinska Institutet published in Emerging Microbes & Infection gives new insights into the virus-host interplay enabling newer ideas to tackle the virus.
New biomarker for severe COVID-19
During the pandemic, it has become evident that people with cardiovascular disease and obesity are at much higher risk of developing very severe, even fatal COVID-19 disease. Researchers at Karolinska Institutet have identified some metabolic processes that SARS-CoV-2 uses to attack lung tissue.