SHEEP - The Stockholm Heart Epidemiology Program

The Stockholm Heart Epidemiology Program (SHEEP) consists of 1 300 post myocardial infarction (MI) patients, 45-70 years of age, and about 1 600 sex- and age-matched controls recruited in 1992-1994 for which biobank materials are available. This case-control study is one of the largest case-control materials in the world on post myocardial infarction patients and has generated over 150 international original articles and about 10 Ph.D theses. Extensive information is available on socio-economic exposures, life-style habits, diet, medical history etc. Blood samples (serum, plasma, citrated and EDTA and whole blood) are frozen in -70 C (in two freezers). DNA has been extracted and amplified.

The SHEEP database has primarily been used to evaluate exposures and risk factors for first time MI as well as for recurrences. Interest has also been directed at analyzing the importance of interaction between various risk factors including gene-environmental interactions using models for biological interactions. Mechanisms of potential significance for atherosclerosis have been identified as well as novel genes that might generate development of new targets for treatment. Emphasis is now very much put on further exploring the functional relevance of the genetic associations identified including the search for rare alleles through deep sequencing. Data from over 200 000 SNPs in a cardiometabolic chip is now available.


Clinical data available

  • BMI
  • Waist-hip ratio
  • Blood pressure diastol.
  • Blood pressure systol.
  • Insulin
  • CRP
  • Fibrinogen
  • HDL cholesterol
  • IGFBP1
  • Interleukin-6
  • LDL cholesterol
  • Lp(a)
  • PAI-1
  • Triglycerides
  • Total cholesterol
  • TLRF4
  • Apo A
  • Apo B


Link to questionnaire (Pdf file, 5 Mb)



Genotype data from the SHEEP is used in a number of international collaborations (Jackson Laboratory, USA, Oxford, Cambridge, London, Harvard etc) and we currently participate through SHEEP investigators (Ulf de Faire and co-workers) in several large-scale international consortia like C4D, Cardiogram, Cardiogram+ Giant, Magic etc.