Karin Leander
About me
- Associate professor in epidemiology, 2012, KI.
Research group leader at the Institute of Environmental Medicine, KI.
Assignments in education, mainly for the KI Medical Program.
Assignment within risk assessment work at my department.
Member of Karolinska Institutet's Pedagogical Academy.
2005, Doctor of philosophy, KI.
1999, Master of Medical Science with a major in Public Health, KI.
1997, Bachelor of Science in Public Health, KI. Program title: Preventive Medicine.
1992-1996 Courses in Business economy, Law, French and Health Economy at Stockholm University and Stockholm School of Economics.
Research
My research is in the field of cardiovascular epidemiology, with a general aim to increase knowledge of cardiovascular risk factors to improve the scientific basis for primary and secondary prevention in women and men. In my research group, we have a specific focus on cardiometabolic-related factors such as low-grade inflammation, dyslipidemia, hypertension and diabetes, as well as on the importance of lifestyle factors, such as dietary habits, for cardiovascular health.
Furthermore, we have a particular interest in women's health, in terms of possible cardiovascular-related health effects of pregnancy complications, premenstrual tension, menopause-related symptoms and hormone treatments. Another specific focus is the exploration of possible interactions between genetic factors and lifestyle factors in relation to cardiovascular risk. The cardiovascular diseases we study include fatal and non-fatal events of coronary artery disease and stroke as well as aortic aneurysm. We also study the degree of atherosclerosis in the coronary arteries.
Ongoing projects
As principal applicant / principal investigator (PI):
• The Swedish Research Council (VR): Does a low proportion of polyunsaturated fat in the diet, reflected via biomarkers, potentiate the cardiovascular risk associated with having cardiovascular disease in the family?
• PI for the Cohort of 60-year-olds at KI.
• PI for the Stockholm Heart Epidemiology Program (SHEEP) at KI.• PI for the local substudy "Women´s survey" within SCAPIS (Swedish Cardiopulmonary Bioimage study) at the centers in Stockholm and Linköping.
• PI for the COMPREHEND (Studies of register-based health outcomes in relation to hormonal drugs) project.
As co-applicant / "Work Package" manager:
• National Institutes of Health (NIH), USA: Studies of how menopause and estrogen receptor activation affect the risk of developing Alzheimer's disease.
Teaching
- Main supervisor for two PhD students who defended successfully
- one ongoing main supervisor responsibility.
Co-supervisor for four PhD students who defended successfully - four ongoing responsibilities as co-supervisor.
Supervised two postdocs and one assistant professor. Supervised about 10 master's theses.
Member of the Curriculum Committee for the 6-year Medical Program at KI, with assignment as coordinator for the competence area "global and equal care and health".
Course organizer of “Public health and environmental medicine", 12 credit points, term 11, KI 5, 5-year Medical Program.
Member of the KI Medical Program Council, as chair of Theme 7 KI 5, 5-year Medical Program.
Member of the preparation group for course plans, KI Medical Program.
Promoter for the development of interprofessional learning at KI.
Examinant of medical student degree projects, term 8, KI 5, 5-year Medical Program.
Regularly organizer of two doctoral level courses at KI: Epidemiology II: Design of epidemiological studies, and Cardiovascular Epidemiology, both 1, 5 credit points.
Taught more than 800 hours at KI, roughly half within the postgraduate education and half within the undergraduate education.
Articles
- Article: EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING. 2024;25(12):1663-1672
- Journal article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2024;13(17):e033648
- Article: ENVIRONMENTAL EPIDEMIOLOGY. 2024;8(4):e319
- Article: ENVIRONMENTAL RESEARCH. 2024;252(Pt 3):118942
- Article: INTERNATIONAL JOURNAL OF CANCER. 2024;154(11):1900-1910
- Article: SCIENCE OF THE TOTAL ENVIRONMENT. 2024;912:168789
- Article: ENVIRONMENTAL POLLUTION. 2024;343:123097
- Article: STROKE. 2024;55(1):50-58
- Article: GLOBAL HEALTH ACTION. 2023;16(1):2190649
- Article: CARDIOVASCULAR RESEARCH (CVR). 2023;119(16):2594-2606
- Article: ENVIRONMENTAL RESEARCH. 2023;239(Pt 1):117230
- Journal article: OBSTETRIC ANESTHESIA DIGEST. 2023;43(4):173
- Journal article: EUROPEAN HEART JOURNAL. 2023;44:ehad655.2634
- Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2023;118(5):921-929
- Article: SCIENTIFIC REPORTS. 2023;13(1):15011
- Article: BRITISH JOURNAL OF CANCER. 2023;129(4):656-664
- Article: JAMA NETWORK OPEN. 2023;6(9):e2333347
- Article: ENVIRONMENT INTERNATIONAL. 2023;178:108108
- Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2023;82(4):336-349
- Article: DIABETOLOGIA. 2023;66(7):1260-1272
- Article: CIRCULATION. GENOMIC AND PRECISION MEDICINE. 2023;16(3):236-247
- Article: ENVIRONMENTAL RESEARCH. 2023;224:115454
- Article: JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (JAMA). 2023;329(5):393-404
- Article: CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION. 2023;32(1):105-113
- Article: CURRENT RESEARCH IN TRANSLATIONAL MEDICINE. 2023;71(1):103374
- Article: FRONTIERS IN GENETICS. 2023;14:1235337
- Article: ENVIRONMENT INTERNATIONAL. 2023;171:107667
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2023;131(1):17003
- Article: ENVIRONMENTAL RESEARCH. 2022;215(Pt 2):114385
- Article: ENVIRONMENT INTERNATIONAL. 2022;170:107581
- Article: OPEN HEART. 2022;9(2):e002082
- Article: OPEN HEART. 2022;9(2):e002080
- Article: ENVIRONMENT INTERNATIONAL. 2022;166:107341
- Article: ENVIRONMENTAL SCIENCE AND TECHNOLOGY. 2022;56(13):9277-9290
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2022;205(12):1429-1439
- Article: BRITISH JOURNAL OF CANCER. 2022;126(10):1499-1507
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2022;130(3):37007
- Article: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 2022;19(5):2630
- Article: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2022;9:809007
- Article: THE LANCET PLANETARY HEALTH. 2022;6(1):e9-e18
- Article: FRONTIERS IN PHYSIOLOGY. 2022;13:909870
- Article: PLOS MEDICINE. 2021;18(12):e1003853
- Article: INTERNATIONAL JOURNAL OF CANCER. 2021;149(11):1887-1897
- Article: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (EJPC). 2021;28(12):1376-1385
- Article: OPEN HEART. 2021;8(2):e001694
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2021;129(10):107002
- Article: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (EJPC). 2021;28(11):1229-1234
- Article: BMJ OPEN. 2021;11(9):e046040
- Article: THE BMJ. 2021;374:n1904
- Journal article: ISEE CONFERENCE ABSTRACTS. 2021;2021(1)
- Journal article: ISEE CONFERENCE ABSTRACTS. 2021;2021(1)
- Article: HEART LUNG AND CIRCULATION. 2021;30(7):1050-1057
- Article: NATURE GENETICS. 2021;53(6):840-860
- Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2021;10(11):e020419
- Article: MOLECULAR PSYCHIATRY. 2021;26(6):2111-2125
- Article: EUROPEAN RESPIRATORY JOURNAL. 2021;57(6):2003099
- Journal article: EUROPEAN RESPIRATORY JOURNAL. 2021;57(6):2003099
- Article: NATURE COMMUNICATIONS. 2021;12(1):2329
- Article: SCIENTIFIC REPORTS. 2021;11(1):7866
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2021;129(4):47009
- Article: SCIENTIFIC REPORTS. 2021;11(1):5796
- Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2021;10(5):e019592
- Article: EUROPEAN JOURNAL OF NUTRITION. 2021;60(1):123-134
- Article: ENVIRONMENTAL RESEARCH. 2021;193:110568
- Article: ENVIRONMENT INTERNATIONAL. 2021;146:106267
- Article: ENVIRONMENT INTERNATIONAL. 2021;146:106249
- Journal article: HEART LUNG AND CIRCULATION. 2021;30:s277
- Article: EUROPEAN JOURNAL OF NUTRITION. 2020;59(5):2089-2097
- Article: EUROPEAN HEART JOURNAL. 2020;41(26):2430-2438
- Article: JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY. 2020;30(4):730-742
- Article: BIOPRESERVATION AND BIOBANKING. 2020;18(2):122-135
- Article: GENES AND IMMUNITY. 2020;21(2):100-108
- Journal article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2019;58(6):e150
- Article: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2019;48(6):2018-2025
- Journal article: EUROPEAN HEART JOURNAL. 2019;40(Supplement_1):ehz746.0018
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2019;127(10):107012
- Article: HUMAN MOLECULAR GENETICS. 2019;28(15):2615-2633
- Article: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2019;188(6):1033-1054
- Article: CIRCULATION. 2019;139(21):2422-2436
- Article: NATURE GENETICS. 2019;51(4):636-648
- Article: CIRCULATION. GENOMIC AND PRECISION MEDICINE. 2019;12(4):e002471
- Article: CIRCULATION. GENOMIC AND PRECISION MEDICINE. 2019;12(4):e002470
- Article: BMC CARDIOVASCULAR DISORDERS. 2019;19(1):34
- Article: NATURE COMMUNICATIONS. 2019;10(1):376
- Article: CLINICAL NUTRITION. 2018;37(6):2001-2010
- Article: JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH. 2018;72(10):904-910
- Journal article: EUROPEAN HEART JOURNAL. 2018;39(suppl_1):ehy563.p3645
- Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2018;102(3):375-400
- Journal article: PROCEEDINGS FOR ANNUAL MEETING OF THE JAPANESE PHARMACOLOGICAL SOCIETY. 2018;WCP2018(0):po3-14-11
- Article: CARDIOVASCULAR PATHOLOGY. 2018;32:32-37
- Article: PLOS ONE. 2018;13(6):e0198166
- Article: NUTRIENTS. 2017;9(12):E1355-1355
- Article: PLOS MEDICINE. 2017;14(11):e1002445
- Article: DIABETES. 2017;66(11):db161253-2902
- Journal article: CLINICAL NUTRITION. 2017;36:s55-s56
- Article: SCANDINAVIAN CARDIOVASCULAR JOURNAL. 2017;51(3):167-171
- Journal article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2017;37(suppl_1)
- Article: NATURE COMMUNICATIONS. 2017;8:14977
- Article: PLOS ONE. 2017;12(4):e0171195
- Article: PLOS ONE. 2017;12(1):e0170684
- Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2016;5(12):e004415
- Journal article: IJC METABOLIC AND ENDOCRINE. 2016;12:30-35
- Article: JOURNAL OF HUMAN NUTRITION AND DIETETICS. 2016;29(3):325-337
- Journal article: EFSA SUPPORTING PUBLICATIONS. 2016;13(5)
- Article: CIRCULATION. 2016;133(13):1230-1239
- Article: EUROPEAN JOURNAL OF NUTRITION. 2016;55(1):247-255
- Article: NATURE GENETICS. 2015;47(12):1415-1425
- Article: ANNALS OF MEDICINE. 2015;47(8):679-686
- Article: PLOS GENETICS. 2015;11(10):e1005378
- Article: ENVIRONMENT INTERNATIONAL. 2015;82:76-84
- Journal article: CLINICAL NUTRITION. 2015;34:s216
- Article: JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY. 2015;25(5):517-523
- Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2015;4(8):e001853
- Article: ATHEROSCLEROSIS. 2015;240(2):477-481
- Article: DIABETOLOGIA. 2015;58(6):1363-1371
- Article: MENOPAUSE. 2015;22(6):598-606
- Article: OBESITY REVIEWS. 2015;16(4):327-340
- Article: CYTOKINE. 2015;72(2):178-184
- Article: ATHEROSCLEROSIS. 2015;239(1):125-130
- Article: NATURE. 2015;518(7538):187-196
- Article: NATURE. 2015;518(7538):197-206
- Article: ANNALS OF MEDICINE. 2015;47(1):28-33
- Article: PLOS ONE. 2015;10(7):e0132601
- Article: PLOS ONE. 2015;10(5):e0127111
- Article: PREVENTIVE MEDICINE. 2014;69:151-156
- Journal article: ISEE CONFERENCE ABSTRACTS. 2014;2014(1)
- Article: ATHEROSCLEROSIS. 2014;236(2):394-399
- Journal article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2014;48(3):344
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2014;122(9):919-925
- Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2014;34(9):2068-2077
- Article: NUTRITION, METABOLISM AND CARDIOVASCULAR DISEASES. 2014;24(8):891-899
- Article: ENVIRONMENT INTERNATIONAL. 2014;66:97-106
- Article: CIRCULATION. GENOMIC AND PRECISION MEDICINE. 2014;7(2):171-177
- Article: BRITISH JOURNAL OF SURGERY. 2014;101(5):481-487
- Article: NATURE GENETICS. 2014;46(3):234-244
- Article: INTERNATIONAL JOURNAL OF CARDIOLOGY. 2014;172(1):173-178
- Article: BMC PUBLIC HEALTH. 2014;14:17
- Article: ATHEROSCLEROSIS. 2014;232(1):242-248
- Article: HEART. 2013;99(23):1761-1765
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2013;37(12):1579-1585
- Article: STATISTICS IN MEDICINE. 2013;32(27):4726-4747
- Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2013;33(11):2633-2638
- Article: INTERNATIONAL JOURNAL OF CARDIOLOGY. 2013;168(2):946-952
- Article: BMJ OPEN. 2013;3(9):e003058
- Journal article: EUROPEAN HEART JOURNAL. 2013;34(suppl_1):p1564
- Article: BMC CARDIOVASCULAR DISORDERS. 2013;13:1
- Article: PLOS ONE. 2013;8(4):e61763
- Journal article: NATURE GENETICS. 2013;45(1):25-U52
- Article: NATURE GENETICS. 2013;45(1):25-33
- Article: CIRCULATION. GENOMIC AND PRECISION MEDICINE. 2012;5(6):656-665
- Article: BMC CARDIOVASCULAR DISORDERS. 2012;12:90
- Article: NATURE GENETICS. 2012;44(9):981-990
- Article: HEART. 2012;98(16):1242-1245
- Article: THROMBOSIS RESEARCH. 2012;130(2):221-225
- Article: THROMBOSIS AND HAEMOSTASIS. 2012;107(6):1092-1099
- Article: NATURE GENETICS. 2012;44(6):659-669
- Article: CLINICA CHIMICA ACTA. 2012;413(7-8):727-732
- Article: EUROPEAN HEART JOURNAL. 2012;33(3):393-407
- Article: ATHEROSCLEROSIS. 2012;220(2):486-492
- Article: JOURNAL OF INTERNAL MEDICINE. 2011;270(3):229-236
- Article: PLOS GENETICS. 2011;7(9):e1002260
- Article: NATURE GENETICS. 2011;43(4):333-338
- Article: NATURE GENETICS. 2011;43(4):339-U89
- Article: METABOLISM: CLINICAL AND EXPERIMENTAL. 2010;59(12):1736-1741
- Article: PLOS ONE. 2010;5(6):e11300
- Article: NEW ENGLAND JOURNAL OF MEDICINE. 2009;361(26):2518-2528
- Article: OCCUPATIONAL AND ENVIRONMENTAL MEDICINE. 2009;66(11):747-753
- Journal article: ATHEROSCLEROSIS PLUS. 2009;10(2):e1017
- Article: DIABETES CARE. 2008;31(5):887-892
- Article: JOURNAL OF CARDIOVASCULAR RISK. 2007;14(4):532-537
- Article: JOURNAL OF INTERNAL MEDICINE. 2007;261(2):138-147
- Article: THROMBOSIS RESEARCH. 2005;116(3):223-232
- Article: THROMBOSIS AND HAEMOSTASIS. 2003;89(6):1064-1071
- Article: JOURNAL OF INTERNAL MEDICINE. 2002;252(4):332-341
- Journal article: ATHEROSCLEROSIS. 2000;151(1):125
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All other publications
- Review: ENVIRONMENTAL RESEARCH. 2022;213:113705
- Conference publication: ISEE CONFERENCE ABSTRACTS. 2022;2022(1)
- Corrigendum: JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY. 2022;32(5):782
- Review: FRONTIERS IN NUTRITION. 2022;9:875607
- Review: ESSAYS IN BIOCHEMISTRY. 2021;65(6):913-925
- Editorial comment: RESUSCITATION. 2021;168:223-224
- Review: PLOS MEDICINE. 2021;18(9):e1003763
- Conference publication: CIRCULATION. 2021;143:a026
- Preprint: BIORXIV. 2020
- Corrigendum: JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY. 2020;30(4):768
- Conference publication: EUROPEAN HEART JOURNAL. 2019;40:3024
- Conference publication: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 2019;28:333-334
- Conference publication: EUROPEAN HEART JOURNAL. 2018;39:757
- Conference publication: CIRCULATION. 2018;138
- Conference publication: CIRCULATION. 2018;138
- Conference publication: ANNALS OF NUTRITION AND METABOLISM. 2017;71:322-323
- Conference publication: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2017;37
- Corrigendum: PLOS GENETICS. 2016;12(6):e1006166
- Conference publication: CIRCULATION. 2016;134
- Conference publication: CIRCULATION. 2016;134
- Conference publication: THE FASEB JOURNAL. 2015;29
- Conference publication: MENOPAUSE. 2015;22(12):1373
- Review: ENVIRONMENTAL HEALTH PERSPECTIVES. 2014;122(9):896-905
- Conference publication: ATHEROSCLEROSIS. 2014;235(2):E48-E49
- Conference publication: CARDIOVASCULAR RESEARCH (CVR). 2014;103:s44
- Letter: INTERNATIONAL JOURNAL OF CARDIOLOGY. 2014;173(3):560
- Conference publication: EUROPEAN HEART JOURNAL. 2014;35:436
- Conference publication: EUROPEAN HEART JOURNAL. 2014;35:205
- Conference publication: EUROPEAN HEART JOURNAL. 2014;35:370-371
- Conference publication: EUROPEAN HEART JOURNAL. 2013;34:306
- Published conference paper: BRITISH JOURNAL OF SURGERY. 2012;99(5):647-653
- Conference publication: EUROPEAN HEART JOURNAL. 2012;33:810
- Conference publication: CARDIOVASCULAR RESEARCH (CVR). 2012;93:S7
- Conference publication: EUROPEAN HEART JOURNAL. 2011;32:652-653
- Conference publication: EUROPEAN HEART JOURNAL. 2011;32:540
- Conference publication: EUROPEAN HEART JOURNAL. 2011;32:539
- Conference publication: EUROPEAN HEART JOURNAL. 2011;32:254-255
- Conference publication: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2011;9:397
- Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2011;183:652-653
- Conference publication: EUROPEAN HEART JOURNAL. 2011;32:536
- Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2010;11(2):13
- Conference publication: EUROPEAN HEART JOURNAL. 2010;31:746
- Conference publication: EUROPEAN HEART JOURNAL. 2010;31:537
- Meeting abstract: EPIDEMIOLOGY. 2009;20(6):S156-S157
- Meeting abstract: ATHEROSCLEROSIS. 2009;207(1):E4
- Conference publication: ATHEROSCLEROSIS SUPPLEMENTS. 2009;10(2)
- Conference publication: CIRCULATION. 2009;120(18):S589
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Grants
- Swedish Research Council1 January 2024 - 31 December 2026
- Swedish Research Council1 January 2023 - 31 December 2025
- Swedish Research Council1 January 2020 - 31 December 2022
- Swedish Heart-Lung Foundation1 January 2019 - 31 December 2021
- Swedish Research Council for Health Working Life and Welfare1 January 2018 - 31 December 2019
- Swedish Research Council1 January 2017 - 31 December 2018
- Familial factors and cardiovascular disease-genetic-epidemiological studies and molecular mechanismsSwedish Research Council1 January 2014 - 31 December 2016
Employments
- Senior Lecturer, Institute of Environmental Medicine, Karolinska Institutet, 2019-
Degrees and Education
- Docent, Karolinska Institutet, 2012
- Doctor Of Philosophy, Institute of Environmental Medicine, Karolinska Institutet, 2005
- Master Of Medical Science, Karolinska Institutet, 1999
- Bachelor Of Medical Science, Karolinska Institutet, 1997