Yihai Cao

About me
Publications
Grants
CV
Public outreach and news

About me

Professor of Vascular Biology, Cancer Research and Metabolic Research.

Research

Angiogenesis, Cancer, Metastasis, Metabolism, Disease Therapy, Cardiovascular Disease, Ophthalmologic Disease.

Teaching

Undergraduate Education
Graduate Education
Ph.D Education
Postdoctoral Training

Articles

Article: ADVANCED SCIENCE. 2024;:e2402332

Effective Prevention and Treatment of Acute Leukemias in Mice by Activation of Thermogenic Adipose Tissues

Chen R; Cheng T; Xie S; Sun X; Chen M; Zhao S; Ruan Q; Ni X; Rao M; Quan X; Chen K; Zhang S; Cheng T; Xu Y; Chen Y; Yang Y; Cao Y
Article: CELL DEATH AND DIFFERENTIATION. 2024;31(6):697-710

Proteinase 3 depletion attenuates leukemia by promoting myeloid differentiation

Liu H; Sun L; Zhao H; Zhao Z; Zhang S; Jiang S; Cheng T; Wang X; Wang T; Shao Y; Zhu H; Han H; Cao Y; Jiang E; Cao Y; Xu Y
Article: SCIENCE TRANSLATIONAL MEDICINE. 2024;16(747):eadi2952

Tumor-associated NK cells drive MDSC-mediated tumor immune tolerance through the IL-6/STAT3 axis

Neo SY; Tong L; Chong J; Liu Y; Jing X; Oliveira MMS; Chen Y; Chen Z; Lee K; Burduli N; Chen X; Gao J; Ma R; Lim JP; Huo J; Xu S; Alici E; Wickstrom SL; Haglund F; Hartman J; Wagner AK; Cao Y; Kiessling R; Lam KP; Westerberg LS; Lundqvist A
Article: CELLULAR & MOLECULAR IMMUNOLOGY. 2024;21(5):510-526

Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS

Xu C; Zhang L; Xu S; Wang Z; Han Q; Lv Y; Wang X; Zhang X; Zhang Q; Zhang Y; He S; Yuan Q; Bian Y; Li C; Wang J; Xu F; Cao Y; Pang J; Chen Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2024;121(6):e2305947121

Effective treatment of optic neuropathies by intraocular delivery of MSC-sEVs through augmenting the G-CSF- macrophage pathway

Yi W; Xue Y; Qing W; Cao Y; Zhou L; Xu M; Sun Z; Li Y; Mai X; Shi L; He C; Zhang F; Duh EJ; Cao Y; Liu X
Article: SCIENCE CHINA-LIFE SCIENCES. 2024;67(2):332-344

The role of corneal endothelium in macular corneal dystrophy development and recurrence

Zhang B-N; Qi B; Dong C; Zhang B; Cheng J; Wang X; Li S; Zhuang X; Chen S; Duan H; Li D; Zhu S; Li G; Cao Y; Zhou Q; Xie L
Article: FRONTIERS IN ENDOCRINOLOGY. 2024;15:1338147

New mechanistic insights of anti-obesity by sleeve gastrectomy-altered gut microbiota and lipid metabolism

Liu C; Xu Q; Dong S; Ding H; Li B; Zhang D; Liang Y; Li L; Liu Q; Cheng Y; Wu J; Zhu J; Zhong M; Cao Y; Zhang G
Article: HOLIST INTEGR ONCOL. 2024;3(1):11

Cancer-triggered systemic disease and therapeutic targets.

Cao Y
Article: NATURE COMMUNICATIONS. 2023;14(1):7610

Mirabegron displays anticancer effects by globally browning adipose tissues

Sun X; Sui W; Mu Z; Xie S; Deng J; Li S; Seki T; Wu J; Jing X; He X; Wang Y; Li X; Yang Y; Huang P; Ge M; Cao Y
Journal article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2023;135(41)

Titelbild: In situ Engineering of Tumor‐Associated Macrophages via a Nanodrug‐Delivering‐Drug (β‐Elemene@Stanene) Strategy for Enhanced Cancer Chemo‐Immunotherapy (Angew. Chem. 41/2023)

Chen W; Li Y; Liu C; Kang Y; Qin D; Chen S; Zhou J; Liu H; Ferdows BE; Patel DN; Huang X; Koo S; Kong N; Ji X; Cao Y; Tao W; Xie T
Article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2023;62(41):e202308413

In situ Engineering of Tumor-Associated Macrophages via a Nanodrug-Delivering-Drug (β-Elemene@Stanene) Strategy for Enhanced Cancer Chemo-Immunotherapy

Chen W; Li Y; Liu C; Kang Y; Qin D; Chen S; Zhou J; Liu H-J; Ferdows BE; Patel DN; Huang X; Koo S; Kong N; Ji X; Cao Y; Tao W; Xie T
Article: ADVANCED SCIENCE. 2023;10(28):e2301852

Deubiquitinase OTUD5 as a Novel Protector against 4-HNE-Triggered Ferroptosis in Myocardial Ischemia/Reperfusion Injury

Liu L; Pang J; Qin D; Li R; Zou D; Chi K; Wu W; Rui H; Yu H; Zhu W; Liu K; Wu X; Wang J; Xu P; Song X; Cao Y; Wang J; Xu F; Xue L; Chen Y
Article: SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2023;8(1):305

VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway

Lee C; Chen R; Sun G; Liu X; Lin X; He C; Xing L; Liu L; Jensen LD; Kumar A; Langer HF; Ren X; Zhang J; Huang L; Yin X; Kim J; Zhu J; Huang G; Li J; Lu W; Chen W; Liu J; Hu J; Sun Q; Lu W; Fang L; Wang S; Kuang H; Zhang Y; Tian G; Mi J; Kang B-A; Narazaki M; Prodeus A; Schoonjans L; Ornitz DM; Gariepy J; Eelen G; Dewerchin M; Yang Y; Ou J-S; Mora A; Yao J; Zhao C; Liu Y; Carmeliet P; Cao Y; Li X
Article: ADVANCED SCIENCE. 2023;10(24):e2301505

Disruption of the Clock Component Bmal1 in Mice Promotes Cancer Metastasis through the PAI-1-TGF-β-myoCAF-Dependent Mechanism

Wu J; Jing X; Du Q; Sun X; Holgersson K; Gao J; He X; Hosaka K; Zhao C; Tao W; FitzGerald GA; Yang Y; Jensen LD; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(29):e2303740120

KRAS mutation-driven angiopoietin 2 bestows anti-VEGF resistance in epithelial carcinomas

Hosaka K; Andersson P; Wu J; He X; Du Q; Jing X; Seki T; Gao J; Zhang Y; Sun X; Huang P; Yang Y; Ge M; Cao Y
Article: MOLECULAR ONCOLOGY. 2023;17(7):1379-1401

A group of novel VEGF splice variants as alternative therapeutic targets in renal cell carcinoma

Montemagno C; Durivault J; Gastaldi C; Dufies M; Vial V; He X; Ambrosetti D; Kamenskaya A; Negrier S; Bernhard J-C; Borchiellini D; Cao Y; Pages G
Article: ADVANCED SCIENCE. 2023;10(16):e2207439

Glutathione-Scavenging Nanoparticle-Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effects

Liu H-J; Chen W; Wu G; Zhou J; Liu C; Tang Z; Huang X; Gao J; Xiao Y; Kong N; Joshi N; Cao Y; Abdi R; Tao W
Article: CANCER COMMUNICATIONS. 2023;43(6):637-660

Perivascular localized cells commit erythropoiesis in PDGF-B-expressing solid tumors

Hosaka K; Wang C; Zhang S; Lv X; Seki T; Zhang Y; Jing X; Wu J; Du Q; He X; Fan Y; Li X; Kondo M; Yoshihara M; Qian H; Shi L; Zhu P; Xu Y; Yang Y; Cheng T; Cao Y
Journal article: CHINESE JOURNAL OF CANCER. 2023;43(4):i

Cover Image, Volume 43, Issue 4

Suzuki H; Iwamoto H; Seki T; Nakamura T; Masuda A; Sakaue T; Tanaka T; Imamura Y; Niizeki T; Nakano M; Shimose S; Shirono T; Noda Y; Kamachi N; Sakai M; Morita K; Nakayama M; Yoshizumi T; Kuromatsu R; Yano H; Cao Y; Koga H; Torimura T
Article: CANCER COMMUNICATIONS. 2023;43(4):415-434

Tumor-derived insulin-like growth factor-binding protein-1 contributes to resistance of hepatocellular carcinoma to tyrosine kinase inhibitors

Suzuki H; Iwamoto H; Seki T; Nakamura T; Masuda A; Sakaue T; Tanaka T; Imamura Y; Niizeki T; Nakano M; Shimose S; Shirono T; Noda Y; Kamachi N; Sakai M; Morita K; Nakayama M; Yoshizumi T; Kuromatsu R; Yano H; Cao Y; Koga H; Torimura T
Article: GUT. 2023;72(4):710-721

Novel TCF21^high pericyte subpopulation promotes colorectal cancer metastasis by remodelling perivascular matrix

Li X; Pan J; Liu T; Yin W; Miao Q; Zhao Z; Gao Y; Zheng W; Li H; Deng R; Huang D; Qiu S; Zhang Y; Qi Q; Deng L; Huang M; Tang PM-K; Cao Y; Chen M; Ye W; Zhang D
Article: CELLS. 2023;12(3):508

Novel Zebrafish Patient-Derived Tumor Xenograft Methodology for Evaluating Efficacy of Immune-Stimulating BCG Therapy in Urinary Bladder Cancer

Kowald S; Huge Y; Tandiono D; Ali Z; Vazquez-Rodriguez G; Erkstam A; Fahlgren A; Sherif A; Cao Y; Jensen LD
Article: NATURE METABOLISM. 2022;4(12):1674-1683

COVID-19 instigates adipose browning and atrophy through VEGF in small mammals

Jing X; Wu J; Dong C; Gao J; Seki T; Kim C; Urgard E; Hosaka K; Yang Y; Long S; Huang P; Zheng J; Szekely L; Zhang Y; Tao W; Coquet J; Ge M; Chen Y; Adner M; Cao Y
Article: BIOACTIVE MATERIALS. 2022;18:446-458

A facile and general method for synthesis of antibiotic-free protein-based hydrogel: Wound dressing for the eradication of drug-resistant bacteria and biofilms

Ouyang J; Bu Q; Tao N; Chen M; Liu H; Zhou J; Liu J; Deng B; Kong N; Zhang X; Chen T; Cao Y; Tao W
Article: SCIENCE TRANSLATIONAL MEDICINE. 2022;14(673):eabn9061

Dietary ketone body-escalated histone acetylation in megakaryocytes alleviates chemotherapy-induced thrombocytopenia

Xie S; Jiang C; Wu M; Ye Y; Wu B; Sun X; Lv X; Chen R; Yu W; Sun Q; Wu Y; Que R; Li H; Yang L; Liu W; Zuo J; Jensen LD; Huang G; Cao Y; Yang Y
Article: ANGIOGENESIS. 2022;25(4):517-533

PDGFD switches on stem cell endothelial commitment

Lu W; Xu P; Deng B; Zhang J; Zhan Y; Lin X; Xu X; Xia Z; Yang X; Zeng X; Huang L; Xie B; Wang C; Wang S; Kuang H; Han X; Mora A; Cao Y; Jiang Q; Li X
Article: SEMINARS IN CANCER BIOLOGY. 2022;86(Pt 3):251-261

The impact of VEGF on cancer metastasis and systemic disease

Yang Y; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(40):e2203307119

Generation of mega brown adipose tissue in adults by controlling brown adipocyte differentiation in vivo

Du Q; Wu J; Fischer C; Seki T; Jing X; Gao J; He X; Hosaka K; Tong L; Yasue A; Miyake M; Sobajima M; Oyadomari S; Sun X; Yang Y; Zhou Q; Ge M; Tao W; Yao S; Cao Y
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10(10):e005308

Tumor MHC class I expression alters cancer-associated myelopoiesis driven by host NK cells

Neo SY; Jing X; Tong L; Tong D; Gao J; Chen Z; De Los Santos MC; Burduli N; Ferreira SDS; Wagner AK; Alici E; Rolny C; Cao Y; Lundqvist A
Article: CELL REPORTS MEDICINE. 2022;3(9):100659

Targeting of c-MET and AXL by cabozantinib is a potential therapeutic strategy for patients with head and neck cell carcinoma

Hagege A; Saada-Bouzid E; Ambrosetti D; Rastoin O; Boyer J; He X; Rousset J; Montemagno C; Doyen J; Pedeutour F; Parola J; Bourget I; Luciano F; Bozec A; Cao Y; Pages G; Dufies M
Article: NATURE. 2022;608(7922):421-428

Brown-fat-mediated tumour suppression by cold-altered global metabolism

Seki T; Yang Y; Sun X; Lim S; Xie S; Guo Z; Xiong W; Kuroda M; Sakaue H; Hosaka K; Jing X; Yoshihara M; Qu L; Li X; Chen Y; Cao Y
Article: NATURE METABOLISM. 2022;4(6):739-758

Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome

Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
Article: CELL CHEMICAL BIOLOGY. 2022;29(4):572-585.e8

CETSA interaction proteomics define specific RNA-modification pathways as key components of fluorouracil-based cancer drug cytotoxicity

Liang YY; Bacanu S; Sreekumar L; Ramos AD; Dai L; Michaelis M; Cinatl J; Seki T; Cao Y; Coffill CR; Lane DP; Prabhu N; Nordlund P
Article: MOLECULAR THERAPY NUCLEIC ACIDS. 2022;27:880-893

Heterogeneity of human corneal endothelium implicates lncRNA NEAT1 in Fuchs endothelial corneal dystrophy

Wang Q; Dou S; Zhang B; Jiang H; Qi X; Duan H; Wang X; Dong C; Zhang BN; Xie L; Cao Y; Zhou Q; Shi W
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(7):e2112696119

Intravesical delivery of KDM6A-mRNA via mucoadhesive nanoparticles inhibits the metastasis of bladder cancer

Kong N; Zhang R; Wu G; Sui X; Wang J; Kim NY; Blake S; De D; Xie T; Cao Y; Tao W
Article: CHEMICAL ENGINEERING JOURNAL. 2022;429:132328

Proof of concept for dual anticancer effects by a novel nanomaterial-mediated cancer cell killing and nano-radiosensitization

Duo Y; Quan L; Zhu D; Bin Z; Luo G; Wang F-B; Chen J; Cao Y
Article: SCIENCE ADVANCES. 2022;8(2):eabi8683

Imaging and tracing the pattern of adult ovarian angiogenesis implies a strategy against female reproductive aging

Xu X; Mu L; Li L; Liang J; Zhang S; Jia L; Yang X; Dai Y; Zhang J; Wang Y; Niu S; Xia G; Yang Y; Zhang Y; Cao Y; Zhang H
Article: JOURNAL OF CLINICAL INVESTIGATION. 2022;132(1):e146658

Long-term corneal recovery by simultaneous delivery of hPSC-derived corneal endothelial precursors and nicotinamide

Li Z; Duan H; Jia Y; Zhao C; Li W; Wang X; Gong Y; Dong C; Ma B; Dou S; Bin Z; Li D; Cao Y; Xie L; Zhou Q; Shi W
Article: GENETICS IN MEDICINE. 2022;24(1):157-169

Novel loss-of-function variant in DENND5A impedes melanosomal cargo transport and predisposes to familial cutaneous melanoma

Yang M; Johnsson P; Brautigam L; Yang XR; Thrane K; Gao J; Tobin NP; Zhou Y; Yu R; Nagy N; Engstrom PG; Tuominen R; Eriksson H; Lundeberg J; Tucker MA; Goldstein AM; Egyhazi-Brage S; Zhao J; Cao Y; Hoiom V
Article: GUT. 2022;71(1):129-147

Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism

Sun X; He X; Zhang Y; Hosaka K; Andersson P; Wu J; Wu J; Jing X; Du Q; Hui X; Ding B; Guo Z; Hong A; Liu X; Wang Y; Ji Q; Beyaert R; Yang Y; Li Q; Cao Y
Journal article: ADVANCED SCIENCE. 2021;8(21)

Interleukin‐33 is a Novel Immunosuppressor that Protects Cancer Cells from TIL Killing by a Macrophage‐Mediated Shedding Mechanism (Adv. Sci. 21/2021)

Wu J; Chen Z; Wickström SL; Gao J; He X; Jing X; Wu J; Du Q; Yang M; Chen Y; Zhang D; Yin X; Guo Z; Jensen L; Yang Y; Tao W; Lundqvist A; Kiessling R; Cao Y
Article: ADVANCED SCIENCE. 2021;8(21):e2101936

A Novel Mechanism of Endoplasmic Reticulum Stress- and c-Myc-Degradation-Mediated Therapeutic Benefits of Antineurokinin-1 Receptor Drugs in Colorectal Cancer

Shi Y; Wang X; Meng Y; Ma J; Zhang Q; Shao G; Wang L; Cheng X; Hong X; Wang Y; Yan Z; Cao Y; Kang J; Fu C
Article: ADVANCED SCIENCE. 2021;8(21):e2101029

Interleukin-33 is a Novel Immunosuppressor that Protects Cancer Cells from TIL Killing by a Macrophage-Mediated Shedding Mechanism

Wu J; Chen Z; Wickstrom SL; Gao J; He X; Jing X; Wu J; Du Q; Yang M; Chen Y; Zhang D; Yin X; Guo Z; Jensen L; Yang Y; Tao W; Lundqvist A; Kiessling R; Cao Y
Article: CANCER LETTERS. 2021;520:48-56

miR-125a-5p impairs the metastatic potential in breast cancer via IP₆K1 targeting

Minini M; Senni A; He X; Proietti S; Liguoro D; Catizone A; Giuliani A; Mancini R; Fuso A; Cucina A; Cao Y; Bizzarri M
Journal article: EXPLORATION. 2021;1(2):20210051

The impact of the hypoxia-VEGF-vascular permeability on COVID-19-infected patients.

Cao Y
Article: ADVANCED FUNCTIONAL MATERIALS. 2021;31(42)

Nanopoxia: Targeting Cancer Hypoxia by Antimonene-Based Nanoplatform for Precision Cancer Therapy

Qiu M; Duo Y; Liang W; Yang Y; Zhang B; Xie Z; Yang X; Wang G; Xie N; Nie G; Alhartomy OA; ALGhamdi AA; Wageh S; Cao Y; Zhang H
Journal article: EMERGENCY AND CRITICAL CARE MEDICINE. 2021;1(1):2-5

Treatment of acute pulmonary edema by blocking VEGF-induced vascular leakage

Cao Y
Article: OCULAR SURFACE. 2021;21:206-220

Molecular identity of human limbal heterogeneity involved in corneal homeostasis and privilege

Dou S; Wang Q; Qi X; Zhang B; Jiang H; Chen S; Duan H; Lu Y; Dong J; Cao Y; Xie L; Zhou Q; Shi W
Article: NANO TODAY. 2021;38:101197

A novel NIR-responsive CO gas-releasing and hyperthermia-generating nanomedicine provides a curative approach for cancer therapy

Jin Z; Duo Y; Li Y; Qiu M; Jiang M; Liu Q; Zhao P; Yang T; Liang W; Zhang H; Cao Y; He Q
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2021;9(6):e002616

Off-tumor IDO1 target engagements determine the cancer-immune set point and predict the immunotherapeutic efficacy

Xie L; Hu K; Duo Y; Shimokawa T; Kumata K; Zhang Y; Jiang C; Zhang L; Nengaki N; Wakizaka H; Cao Y; Zhang M-R
Article: HELIYON. 2021;7(5):e07134

Pulmonary stromal expansion and intra-alveolar coagulation are primary causes of COVID-19 death

Szekely L; Bozoky B; Bendek M; Ostad M; Lavignasse P; Haag L; Wu J; Jing X; Gupta S; Saccon E; Sonnerberg A; Cao Y; Bjornstedt M; Szakos A
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2021;10(7):e12096

Perivascular cell-derived extracellular vesicles stimulate colorectal cancer revascularization after withdrawal of antiangiogenic drugs

Huang M; Chen M; Qi M; Ye G; Pan J; Shi C; Yang Y; Zhao L; Mo X; Zhang Y; Li Y; Zhong J; Lu W; Li X; Zhang J; Lin J; Luo L; Liu T; Tang PM-K; Hong A; Cao Y; Ye W; Zhang D
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(11):e2023290118

A specific RIP3⁺ subpopulation of microglia promotes retinopathy through a hypoxia-triggered necroptotic mechanism

He C; Liu Y; Huang Z; Yang Z; Zhou T; Liu S; Hao Z; Wang J; Feng Q; Liu Y; Cao Y; Liu X
Article: EMBO REPORTS. 2021;22(3):e51329

Phosphodiesterase 4A confers resistance to PGE2-mediated suppression in CD25⁺/CD54⁺ NK cells

Chen Z; Yang Y; Neo SY; Shi H; Chen Y; Wagner AK; Larsson K; Tong L; Jakobsson P-J; Alici E; Wu J; Cao Y; Wang K; Liu LL; Mao Y; Sarhan D; Lundqvist A
Article: COMMUNICATIONS BIOLOGY. 2021;4(1):166

Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma

Dufies M; Verbiest A; Cooley LS; Ndiaye PD; He X; Nottet N; Souleyreau W; Hagege A; Torrino S; Parola J; Giuliano S; Borchiellini D; Schiappa R; Mograbi B; Zucman-Rossi J; Bensalah K; Ravaud A; Auberger P; Bikfalvi A; Chamorey E; Rioux-Leclercq N; Mazure NM; Beuselinck B; Cao Y; Bernhard JC; Ambrosetti D; Pages G
Article: NATURE COMMUNICATIONS. 2021;12(1):814

Efficacy and tolerability of bevacizumab in patients with severe Covid-19

Pang J; Xu F; Aondio G; Li Y; Fumagalli A; Lu M; Valmadre G; Wei J; Bian Y; Canesi M; Damiani G; Zhang Y; Yu D; Chen J; Ji X; Sui W; Wang B; Wu S; Kovacs A; Revera M; Wang H; Jing X; Zhang Y; Chen Y; Cao Y
Article: NANO TODAY. 2021;36:101023

Nano-immunotherapy: Unique mechanisms of nanomaterials in synergizing cancer immunotherapy

Liu Q; Duo Y; Fu J; Qiu M; Sun Z; Adah D; Kang J; Xie Z; Fan T; Bao S; Zhang H; Liu L-P; Cao Y
Article: THERANOSTICS. 2021;11(19):9571-9586

The Polo-like kinase 1 inhibitor onvansertib represents a relevant treatment for head and neck squamous cell carcinoma resistant to cisplatin and radiotherapy

Hagege A; Ambrosetti D; Boyer J; Bozec A; Doyen J; Chamorey E; He X; Bourget I; Rousset J; Saada E; Rastoin O; Parola J; Luciano F; Cao Y; Pages G; Dufies M
Article: ADVANCED SCIENCE. 2020;7(24):2001191

Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer

Liu Q; Xie Z; Qiu M; Shim I; Yang Y; Xie S; Yang Q; Wang D; Chen S; Fan T; Ding B; Guo Z; Adah D; Yao X; Zhang Y; Wu H; Wu Z; Wei C; Wang H; Kim HS; Zou Q; Yan Q; Cai Z; Kim JS; Liu L-P; Zhang H; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(46):28667-28677

In situ sprayed NIR-responsive, analgesic black phosphorus-based gel for diabetic ulcer treatment

Ouyang J; Ji X; Zhang X; Feng C; Tang Z; Kong N; Xie A; Wang J; Sui X; Deng L; Liu Y; Kim JS; Cao Y; Tao W
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(37):22910-22919

Visualization of human T lymphocyte-mediated eradication of cancer cells in vivo

He X; Yin X; Wu J; Wickstrom SL; Duo Y; Du Q; Qin S; Yao S; Jing X; Hosaka K; Wu J; Jensen LD; Lundqvist A; Salter AI; Brautigam L; Tao W; Chen Y; Kiessling R; Cao Y
Article: CELL REPORTS. 2020;32(5):107990

Macrophage K63-Linked Ubiquitination of YAP Promotes Its Nuclear Localization and Exacerbates Atherosclerosis

Liu M; Yan M; Lv H; Wang B; Lv X; Zhang H; Xiang S; Du J; Liu T; Tian Y; Zhang X; Zhou F; Cheng T; Zhu Y; Jiang H; Cao Y; Ai D
Article: NATURE COMMUNICATIONS. 2020;11(1):3704

Therapeutic paradigm of dual targeting VEGF and PDGF for effectively treating FGF-2 off-target tumors

Hosaka K; Yang Y; Seki T; Du Q; Jing X; He X; Wu J; Zhang Y; Morikawa H; Nakamura M; Scherzer M; Sun X; Xu Y; Cheng T; Li X; Liu X; Li Q; Liu Y; Hong A; Chen Y; Cao Y
Article: CANCERS. 2020;12(7):E1883-1883

Fast, In Vivo Model for Drug-Response Prediction in Patients with B-Cell Precursor Acute Lymphoblastic Leukemia

Gauert A; Olk N; Pimentel-Gutierrez H; Astrahantseff K; Jensen LD; Cao Y; Eggert A; Eckert C; Hagemann AIH
Article: SCIENCE ADVANCES. 2020;6(15):eaay6825

Eradication of tumor growth by delivering novel photothermal selenium-coated tellurium nanoheterojunctions

Chen S; Xing C; Huang D; Zhou C; Ding B; Guo Z; Peng Z; Wang D; Zhu X; Liu S; Cai Z; Wu J; Zhao J; Wu Z; Zhang Y; Wei C; Yan Q; Wang H; Fan D; Liu L; Zhang H; Cao Y
Article: NATURE COMMUNICATIONS. 2020;11(1):1211

Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation

Ji Q; Zhou L; Sui H; Yang L; Wu X; Song Q; Jia R; Li R; Sun J; Wang Z; Liu N; Feng Y; Sun X; Cai G; Feng Y; Cai J; Cao Y; Cai G; Wang Y; Li Q
Article: DEVELOPMENTAL BIOLOGY. 2020;457(2):206-214

Synchronized tissue-scale vasculogenesis and ubiquitous lateral sprouting underlie the unique architecture of the choriocapillaris

Ali Z; Cui D; Yang Y; Tracey-White D; Vazquez-Rodriguez G; Moosajee M; Ju R; Li X; Cao Y; Jensen LD
Article: AUTOPHAGY. 2020;16(1):106-122

Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma

Jiang J; Zhang L; Chen H; Lei Y; Zhang T; Wang Y; Jin P; Lan J; Zhou L; Huang Z; Li B; Liu Y; Gao W; Xie K; Zhou L; Nice EC; Peng Y; Cao Y; Wei Y; Wang K; Huang C
Article: FRONTIERS IN PHARMACOLOGY. 2020;11:373

Aldehyde Dehydrogenase 2 Protects Against Post-Cardiac Arrest Myocardial Dysfunction Through a Novel Mechanism of Suppressing Mitochondrial Reactive Oxygen Species Production

Zhang R; Liu B; Fan X; Wang W; Xu T; Wei S; Zheng W; Yuan Q; Gao L; Yin X; Zheng B; Zhang C; Zhang S; Yang K; Xue M; Wang S; Xu F; Wang J; Cao Y; Chen Y
Article: SCIENTIFIC REPORTS. 2019;9(1):19384

CETSA-based target engagement of taxanes as biomarkers for efficacy and resistance

Langeback A; Bacanu S; Laursen H; Mout L; Seki T; Erkens-Schulze S; Ramos AD; Berggren A; Cao Y; Hartman J; van Weerden W; Bergh J; Nordlund P; Loof S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(39):19635-19645

Neurokinin-1 receptor is an effective target for treating leukemia by inducing oxidative stress through mitochondrial calcium overload

Ge C; Huang H; Huang F; Yang T; Zhang T; Wu H; Zhou H; Chen Q; Shi Y; Sun Y; Liu L; Wang X; Pearson RB; Cao Y; Kang J; Fu C
Article: EMBO MOLECULAR MEDICINE. 2019;11(8):e9266

Apelin inhibition prevents resistance and metastasis associated with anti-angiogenic therapy

Uribesalgo I; Hoffmann D; Zhang Y; Kavirayani A; Lazovic J; Berta J; Novatchkova M; Pai T-P; Wimmer RA; Laszlo V; Schramek D; Karim R; Tortola L; Deswal S; Haas L; Zuber J; Szucs M; Kuba K; Dome B; Cao Y; Haubner BJ; Penninger JM
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2019;39(7):1402-1418

Intussusceptive Vascular Remodeling Precedes Pathological Neovascularization

Ali Z; Mukwaya A; Biesemeier A; Ntzouni M; Ramskold D; Giatrellis S; Mammadzada P; Cao R; Lennikov A; Marass M; Gerri C; Hildesjo C; Taylor M; Deng Q; Peebo B; del Peso L; Kvanta A; Sandberg R; Schraermeyer U; Andre H; Steffensen JF; Lagali N; Cao Y; Kele J; Dahl Jensen L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(22):10937-10942

Bladder drug mirabegron exacerbates atherosclerosis through activation of brown fat-mediated lipolysis

Sui W; Li H; Yang Y; Jing X; Xue F; Cheng J; Dong M; Zhang M; Pan H; Chen Y; Zhang Y; Zhou Q; Shi W; Wang X; Zhang H; Zhang C; Zhang Y; Cao Y
Article: CIRCULATION. 2018;138(23):2698-2712

Decreased Expression of Vascular Endothelial Growth Factor Receptor 1 Contributes to the Pathogenesis of Hereditary Hemorrhagic Telangiectasia Type 2

Thalgott JH; Dos-Santos-Luis D; Hosman AE; Martin S; Lamande N; Bracquart D; Srun S; Galaris G; de Boer HC; Tual-Chalot S; Kroon S; Arthur HM; Cao Y; Snijder RJ; Disch F; Mager JJ; Rabelink TJ; Mummery CL; Raymond K; Lebrin F
Article: JOURNAL OF PATHOLOGY. 2018;246(4):447-458

Targeting PDGF-mediated recruitment of pericytes blocks vascular mimicry and tumor growth

Thijssen VLJL; Paulis YWJ; Nowak-Sliwinska P; Deumelandt KL; Hosaka K; Soetekouw PMMB; Cimpean AM; Raica M; Pauwels P; van den Oord JJ; Tjan-Heijnen VCG; Hendrix MJ; Heldin C-H; Cao Y; Griffioen AW
Article: JCI INSIGHT. 2018;3(20):e122375

Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis

Andersson P; Yang Y; Hosaka K; Zhang Y; Fischer C; Braun H; Liu S; Yu G; Liu S; Beyaert R; Chang M; Li Q; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(41):10351-10356

VEGF-B is a potent antioxidant

Arjunan P; Lin X; Tang Z; Du Y; Kumar A; Liu L; Yin X; Huang L; Chen W; Chen Q; Ye Z; Wang S; Kuang H; Zhou L; Xu K; Chen X; Zeng H; Lu W; Cao Y; Liu Y; Zhao C; Li X
Article: MOLECULAR CARCINOGENESIS. 2018;57(9):1201-1212

A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis

Wang R; Jin Y; Yao X-H; Fan W; Zhang J; Cao Y; Li J
Article: CELL METABOLISM. 2018;28(1):104-117.e5

Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance

Iwamoto H; Abe M; Yang Y; Cui D; Seki T; Nakamura M; Hosaka K; Lim S; Wu J; He X; Sun X; Lu Y; Zhou Q; Shi W; Torimura T; Nie G; Li Q; Cao Y
Article: JOURNAL OF CLINICAL INVESTIGATION. 2018;128(3):1106-1124

CD163⁺ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis

Guo L; Akahori H; Harari E; Smith SL; Polavarapu R; Karmali V; Otsuka F; Gannon RL; Braumann RE; Dickinson MH; Gupta A; Jenkins AL; Lipinski MJ; Kim J; Chhour P; de Vries PS; Jinnouchi H; Kutys R; Mori H; Kutyna MD; Torii S; Sakamoto A; Choi CU; Cheng Q; Grove ML; Sawan MA; Zhang Y; Cao Y; Kolodgie FD; Cormode DP; Arking DE; Boerwinkle E; Morrison AC; Erdmann J; Sotoodehnia N; Virmani R; Finn AV
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2018;215(2):611-626

Ablation of endothelial VEGFR1 improves metabolic dysfunction by inducing adipose tissue browning

Seki T; Hosaka K; Fischer C; Lim S; Andersson P; Abe M; Iwamoto H; Gao Y; Wang X; Fong G-H; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(3):501-506

Novel concept of the smart NIR-light-controlled drug release of black phosphorus nanostructure for cancer therapy

Qiu M; Wang D; Liang W; Liu L; Zhang Y; Chen X; Sang DK; Xing C; Li Z; Dong B; Xing F; Fan D; Bao S; Zhang H; Cao Y
Article: CELL DISCOVERY. 2018;4:3

Dual roles of endothelial FGF-2-FGFR1-PDGF-BB and perivascular FGF-2-FGFR2-PDGFRβ signaling pathways in tumor vascular remodeling

Hosaka K; Yang Y; Nakamura M; Andersson P; Yang X; Zhang Y; Seki T; Scherzer M; Dubey O; Wang X; Cao Y
Article: NATURE COMMUNICATIONS. 2017;8(1):2079

A miR-327-FGF10-FGFR2-mediated autocrine signaling mechanism controls white fat browning

Fischer C; Seki T; Lim S; Nakamura M; Andersson P; Yang Y; Honek J; Wang Y; Gao Y; Chen F; Samani NJ; Zhang J; Miyake M; Oyadomari S; Yasue A; Li X; Zhang Y; Liu Y; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(45):E9635-E9644

Off-tumor targets compromise antiangiogenic drug sensitivity by inducing kidney erythropoietin production

Nakamura M; Zhang Y; Yang Y; Sonmez C; Zheng W; Huang G; Seki T; Iwamoto H; Ding B; Yin L; Foukakis T; Hatschek T; Li X; Hosaka K; Li J; Yu G; Wang X; Liu Y; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(40):10737-10742

Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK

Jiang Y; Lin X; Tang Z; Lee C; Tian G; Du Y; Yin X; Ren X; Huang L; Ye Z; Chen W; Zhang F; Mi J; Gao Z; Wang S; Chen Q; Xing L; Wang B; Cao Y; Sessa WC; Ju R; Liu Y; Li X
Article: CLINICAL CANCER RESEARCH. 2017;23(16):4769-4779

A Zebrafish Model Discovers a Novel Mechanism of Stromal Fibroblast-Mediated Cancer Metastasis

Liu C; Zhang Y; Lim S; Hosaka K; Yang Y; Pavlova T; Alkasalias T; Hartman J; Jensen L; Xing X; Wang X; Lu Y; Nie G; Cao Y
Article: CELL DEATH AND DIFFERENTIATION. 2017;24(8):1431-1442

MicroRNA-26a and-26b inhibit lens fibrosis and cataract by negatively regulating Jagged-1/Notch signaling pathway

Chen X; Xiao W; Chen W; Liu X; Wu M; Bo Q; Luo Y; Ye S; Cao Y; Liu Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(26):E5226-E5235

Maintenance of antiangiogenic and antitumor effects by orally active low-dose capecitabine for long-term cancer therapy

Zhang Y; Sun M; Huang G; Yin L; Lai Q; Yang Y; Xing X; Yu G; Sun Y; Wang X; Nie G; Liu Y; Cao Y
Article: JCI INSIGHT. 2017;2(4):e89044

Switching harmful visceral fat to beneficial energy combustion improves metabolic dysfunctions

Yang X; Sui W; Zhang M; Dong M; Lim S; Seki T; Guo Z; Fischer C; Lu H; Zhang C; Yang J; Zhang M; Wang Y; Cao C; Gao Y; Zhao X; Sun M; Sun Y; Zhuang R; Samani NJ; Zhang Y; Cao Y
Article: CANCER RESEARCH. 2016;76(19):5634-5646

Estrogen Receptor a Promotes Breast Cancer by Reprogramming Choline Metabolism

Jia M; Andreassen T; Jensen L; Bathen TF; Sinha I; Gao H; Zhao C; Haldosen L-A; Cao Y; Girnita L; Moestue SA; Dahlman-Wright K
Article: ONCOGENE. 2016;35(39):5155-5169

Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE

Carmona G; Perera U; Gillett C; Naba A; Law A-L; Sharma VP; Wang J; Wyckoff J; Balsamo M; Mosis F; De Piano M; Monypenny J; Woodman N; McConnell RE; Mouneimne G; Van Hemelrijck M; Cao Y; Condeelis J; Hynes RO; Gertler FB; Krause M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(38):E5618-E5627

Pericyte-fibroblast transition promotes tumor growth and metastasis

Hosaka K; Yang Y; Seki T; Fischer C; Dubey O; Fredlund E; Hartman J; Religa P; Morikawa H; Ishii Y; Sasahara M; Larsson O; Cossu G; Cao R; Lim S; Cao Y
Article: NATURE COMMUNICATIONS. 2016;7:12680

Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism

Yang Y; Zhang Y; Iwamoto H; Hosaka K; Seki T; Andersson P; Lim S; Fischer C; Nakamura M; Abe M; Cao R; Skov PV; Chen F; Chen X; Lu Y; Nie G; Cao Y
Article: NATURE COMMUNICATIONS. 2016;7:12152

Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat

Seki T; Hosaka K; Lim S; Fischer C; Honek J; Yang Y; Andersson P; Nakamura M; Naslund E; Yla-Herttuala S; Sun M; Iwamoto H; Li X; Liu Y; Samani NJ; Cao Y
Article: ONCOTARGET. 2016;7(25):38282-38291

Co-option of pre-existing vascular beds in adipose tissue controls tumor growth rates and angiogenesis

Lim S; Hosaka K; Nakamura M; Cao Y
Article: NATURE COMMUNICATIONS. 2016;7:11385

The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages

Yang Y; Andersson P; Hosaka K; Zhang Y; Cao R; Iwamoto H; Yang X; Nakamura M; Wang J; Zhuang R; Morikawa H; Xue Y; Braun H; Beyaert R; Samani N; Nakae S; Hams E; Dissing S; Fallon PG; Langer R; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(15):4158-4163

Endocrine vasculatures are preferable targets of an antitumor ineffective low dose of anti-VEGF therapy

Zhang Y; Yang Y; Hosaka K; Huang G; Zang J; Chen F; Zhang Y; Samani NJ; Cao Y
Article: NATURE COMMUNICATIONS. 2016;7:10824

MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis

Wong HLX; Jin G; Cao R; Zhang S; Cao Y; Zhou Z
Article: SCIENTIFIC REPORTS. 2016;6:19973

Resveratrol analogue 4,4′-dihydroxy-trans-stilbene potently inhibits cancer invasion and metastasis

Savio M; Ferraro D; Maccario C; Vaccarone R; Jensen LD; Corana F; Mannucci B; Bianchi L; Cao Y; Stivala LA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(44):E5944-E5953

VEGF-B-Neuropilin-1 signaling is spatiotemporally indispensable for vascular and neuronal development in zebrafish

Jensen LD; Nakamura M; Brautigam L; Li X; Liu Y; Samani NJ; Cao Y
Article: ELIFE. 2015;4:e08422

Environmental changes in oxygen tension reveal ROS-dependent neurogenesis and regeneration in the adult newt brain

Hameed LS; Berg DA; Belnoue L; Jensen LD; Cao Y; Simon A
Article: ONCOGENE. 2015;34(37):4867-4878

MicroRNA-206 functions as a pleiotropic modulator of cell proliferation, invasion and lymphangiogenesis in pancreatic adenocarcinoma by targeting ANXA2 and KRAS genes

Keklikoglou I; Hosaka K; Bender C; Bott A; Koerner C; Mitra D; Will R; Woerner A; Muenstermann E; Wilhelm H; Cao Y; Wiemann S
Article: ONCOGENE. 2015;34(36):4713-4722

Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis

Singleton DC; Rouhi P; Zois CE; Haider S; Li J-L; Kessler BM; Cao Y; Harris AL
Article: CLINICAL CANCER RESEARCH. 2015;21(16):3794-3805

CCL2 and CCL5 Are Novel Therapeutic Targets for Estrogen-Dependent Breast Cancer

Svensson S; Abrahamsson A; Rodriguez GV; Olsson A-K; Jensen L; Cao Y; Dabrosin C
Article: SCIENTIFIC REPORTS. 2015;5:10351

Invasiveness and metastasis of retinoblastoma in an orthotopic zebrafish tumor model

Chen X; Wang J; Cao Z; Hosaka K; Jensen L; Yang H; Sun Y; Zhuang R; Liu Y; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(22):E2900-E2909

VEGF-B promotes cancer metastasis through a VEGF-A-independent mechanism and serves as a marker of poor prognosis for cancer patients

Yang X; Zhang Y; Hosaka K; Andersson P; Wang J; Tholander F; Cao Z; Morikawa H; Tegner J; Yang Y; Iwamoto H; Lim S; Cao Y
Article: SCIENCE ADVANCES. 2015;1(3):e1400244

PlGF-induced VEGFR1-dependent vascular remodeling determines opposing antitumor effects and drug resistance to Dll4-Notch inhibitors

Iwamoto H; Zhang Y; Seki T; Yang Y; Nakamura M; Wang J; Yang X; Torimura T; Cao Y
Article: CANCER RESEARCH. 2015;75(2):306-315

Novel Mechanism of Macrophage-Mediated Metastasis Revealed in a Zebrafish Model of Tumor Development

Wang J; Cao Z; Zhang X-M; Nakamura M; Sun M; Hartman J; Harris RA; Sun Y; Cao Y
Article: CELL REPORTS. 2014;9(2):569-580

VEGFR2-Mediated Vascular Dilation as a Mechanism of VEGF-Induced Anemia and Bone Marrow Cell Mobilization

Lim S; Zhang Y; Zhang D; Chen F; Hosaka K; Feng N; Seki T; Andersson P; Li J; Zang J; Sun B; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(41):14906-14911

Modulation of age-related insulin sensitivity by VEGF-dependent vascular plasticity in adipose tissues

Honek J; Seki T; Iwamoto H; Fischer C; Li J; Lim S; Samani NJ; Zang J; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(41):14806-14811

Vasoprotective effect of PDGF-CC mediated by HMOX1 rescues retinal degeneration

He C; Zhao C; Kumar A; Lee C; Chen M; Huang L; Wang J; Ren X; Jiang Y; Chen W; Wang B; Gao Z; Zhong Z; Huang Z; Zhang F; Huang B; Ding H; Ju R; Tang Z; Liu Y; Cao Y; Li X; Liu X
Article: ONCOGENESIS. 2014;3(9):e119

Targeting filamin B induces tumor growth and metastasis via enhanced activity of matrix metalloproteinase-9 and secretion of VEGF-A

Bandaru S; Zhou A-X; Rouhi P; Zhang Y; Bergo MO; Cao Y; Akyurek LM
Article: NATURE COMMUNICATIONS. 2014;5:4944

TNFR1 mediates TNF-α-induced tumour lymphangiogenesis and metastasis by modulating VEGF-C-VEGFR3 signalling

Ji H; Cao R; Yang Y; Zhang Y; Iwamoto H; Lim S; Nakamura M; Andersson P; Wang J; Sun Y; Dissing S; He X; Yang X; Cao Y
Article: CANCER RESEARCH. 2014;74(14):3983-3994

Genome-wide Profiling of AP-1-Regulated Transcription Provides Insights into the Invasiveness of Triple-Negative Breast Cancer

Zhao C; Qiao Y; Jonsson P; Wang J; Xu L; Rouhi P; Sinha I; Cao Y; Williams C; Dahlman-Wright K
Article: JOURNAL OF CLINICAL INVESTIGATION. 2014;124(3):1069-1082

Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis

Arjonen A; Kaukonen R; Mattila E; Rouhi P; Hognas G; Sihto H; Miller BW; Morton JP; Bucher E; Taimen P; Virtakoivu R; Cao Y; Sansom OJ; Joensuu H; Ivaska J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(7):2560-2565

Hypoxia-induced and calpain-dependent cleavage of filamin A regulates the hypoxic response

Zheng X; Zhou A-X; Rouhi P; Uramoto H; Boren J; Cao Y; Pereira T; Akyurek LM; Poellinger L
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(2):90-97

Angiostatic Effects of NK Cell-Derived IFN-γ Counteracted by Tumour Cell Bcl-x_L Expression

Wallin RPA; Sundquist VS; Brakenhielm E; Cao Y; Ljunggren H-G; Grandien A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(50):20057-20062

Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1

Brautigam L; Jensen LDE; Poschmann G; Nystrom S; Bannenberg S; Dreij K; Lepka K; Prozorovski T; Montano SJ; Aktas O; Uhlen P; Stuehler K; Cao Y; Holmgren A; Berndt C
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(34):13932-13937

Vascular endothelial growth factor-dependent spatiotemporal dual roles of placental growth factor in modulation of angiogenesis and tumor growth

Yang X; Zhang Y; Yang Y; Lim S; Cao Z; Rak J; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(29):12018-12023

Anti-VEGF- and anti-VEGF receptor-induced vascular alteration in mouse healthy tissues

Yang Y; Zhang Y; Cao Z; Ji H; Yang X; Iwamoto H; Wahlberg E; Lanne T; Sun B; Cao Y
Article: SCIENCE. 2013;341(6141):84-87

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

Molina DM; Jafari R; Ignatushchenko M; Seki T; Larsson EA; Dan C; Sreekumar L; Cao Y; Nordlund P
Article: CELL METABOLISM. 2013;18(1):118-129

Cold Exposure Promotes Atherosclerotic Plaque Growth and Instability via UCP1-Dependent Lipolysis

Dong M; Yang X; Lim S; Cao Z; Honek J; Lu H; Zhang C; Seki T; Hosaka K; Wahlberg E; Yang J; Zhang L; Lanne T; Sun B; Li X; Liu Y; Zhang Y; Cao Y
Journal article: CANCER RESEARCH. 2013;73(8_Supplement):1623

Abstract 1623: PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells.

Xue Y; Lim S; Yang Y; Wang Z; Jensen LDE; Hedlund E; Andersson P; Sasahara M; Larsson O; Galter D; Cao R; Hosaka K; Cao Y
Article: CELL CYCLE. 2013;12(3):405-408

Clock controls angiogenesis

Jensen LD; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(2):654-659

Tumor cell-derived placental growth factor sensitizes antiangiogenic and antitumor effects of anti-VEGF drugs

Hedlund E-ME; Yang X; Zhang Y; Yang Y; Shibuya M; Zhong W; Sun B; Liu Y; Hosaka K; Cao Y
Article: NATURE COMMUNICATIONS. 2013;4:2129

Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis

Hosaka K; Yang Y; Seki T; Nakamura M; Andersson P; Rouhi P; Yang X; Jensen L; Lim S; Feng N; Xue Y; Li X; Larsson O; Ohhashi T; Cao Y
Article: SCIENTIFIC REPORTS. 2013;3:2053

VEGF significantly restores impaired memory behavior in Alzheimer's mice by improvement of vascular survival

Religa P; Cao R; Religa D; Xue Y; Bogdanovic N; Westaway D; Marti HH; Winblad B; Cao Y
Article: CELL REPORTS. 2012;2(5):1272-1285

Proliferative and Survival Effects of PUMA Promote Angiogenesis

Zhang F; Li Y; Tang Z; Kumar A; Lee C; Zhang L; Zhu C; Klotzsche-von Ameln A; Wang B; Gao Z; Zhang S; Langer HF; Hou X; Jensen L; Ma W; Wong W; Chavakis T; Liu Y; Cao Y; Li X
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(39):15894-15899

Collaborative interplay between FGF-2 and VEGF-C promotes lymphangiogenesis and metastasis

Cao R; Ji H; Feng N; Zhang Y; Yang X; Andersson P; Sun Y; Tritsaris K; Hansen AJ; Dissing S; Cao Y
Article: CELL REPORTS. 2012;2(2):231-241

Opposing Effects of Circadian Clock Genes Bmal1 and Period2 in Regulation of VEGF-Dependent Angiogenesis in Developing Zebrafish

Jensen LD; Cao Z; Nakamura M; Yang Y; Brautigam L; Andersson P; Zhang Y; Wahlberg E; Lanne T; Hosaka K; Cao Y
Article: MOLECULAR CANCER. 2012;11:50

Targeting filamin A reduces K-RAS-induced lung adenocarcinomas and endothelial response to tumor growth in mice

Nallapalli RK; Ibrahim MX; Zhou AX; Bandaru S; Sunkara SN; Redfors B; Pazooki D; Zhang Y; Boren J; Cao Y; Bergo MO; Akyurek LM
Article: CELL CYCLE. 2012;11(15):2793-2798

When MT1-MMP meets ADAMs

Wong HLX; Cao R; Jin G; Chan KM; Cao Y; Zhou Z
Article: DEVELOPMENTAL CELL. 2012;22(6):1176-1190

MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling and Calvarial Osteogenesis

Chan KM; Wong HLX; Jin G; Liu B; Cao R; Cao Y; Lehti K; Tryggvason K; Zhou Z
Article: NATURE PROTOCOLS. 2012;7(3):606-615

Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice

Lim S; Honek J; Xue Y; Seki T; Cao Z; Andersson P; Yang X; Hosaka K; Cao Y
Article: NATURE MEDICINE. 2011;18(1):100-110

PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells

Xue Y; Lim S; Yang Y; Wang Z; Jensen LDE; Hedlund E-M; Andersson P; Sasahara M; Larsson O; Galter D; Gao R; Hosaka K; Cao Y
Article: CIRCULATION. 2011;124(9):1059-U170

Arteriogenic Therapy by Intramyocardial Sustained Delivery of a Novel Growth Factor Combination Prevents Chronic Heart Failure

Banquet S; Gomez E; Nicol L; Edwards-Levy F; Henry J-P; Cao R; Schapman D; Dautreaux B; Lallemand F; Bauer F; Cao Y; Thuillez C; Mulder P; Richard V; Brakenhielm E
Article: NATURE PROTOCOLS. 2011;6(6):817-826

Mouse corneal lymphangiogenesis model

Cao R; Lim S; Ji H; Zhang Y; Yang Y; Honek J; Hedlund E-M; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(10):4117-4122

Antiangiogenic agents significantly improve survival in tumor-bearing mice by increasing tolerance to chemotherapy-induced toxicity

Zhang D; Hedlund E-ME; Lim S; Chen F; Zhang Y; Sun B; Cao Y
Journal article: VASCULAR CELL. 2011;3(1):1

It's hard to keep all things angiogenic in one JAR!

Kitajewski J; Cao Y; Slevin M
Article: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 2011;55(4-5):557-562

Antiangiogenic cancer therapy: why do mouse and human patients respond in a different way to the same drug?

Cao Y
Article: NATURE PROTOCOLS. 2010;5(12):1911-1918

Hypoxia-induced metastasis model in embryonic zebrafish

Rouhi P; Jensen LD; Cao Z; Hosaka K; Lanne T; Wahlberg E; Steffensen JF; Cao Y
Article: NATURE PROTOCOLS. 2010;5(12):1903-1910

Hypoxia-induced retinopathy model in adult zebrafish

Cao Z; Jensen LD; Rouhi P; Hosaka K; Lanne T; Steffensen JF; Wahlberg E; Cao Y
Article: PHYSICAL BIOLOGY. 2010;7(4):046007

Collective cell motion in endothelial monolayers

Szabo A; Uennep R; Mehes E; Twal WO; Argraves WS; Cao Y; Czirok A
Article: NATURE REVIEWS CLINICAL ONCOLOGY. 2010;7(10):604-608

Off-tumor target-beneficial site for antiangiogenic cancer therapy?

Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(36):15886-15891

Angiotensin-converting enzyme 2 attenuates atherosclerotic lesions by targeting vascular cells

Zhang C; Zhao YX; Zhang YH; Zhu L; Deng BP; Zhou ZL; Li SY; Lu XT; Song LL; Lei XM; Tang WB; Wang N; Pan CM; Song HD; Liu CX; Dong B; Zhang Y; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(27):12216-12221

PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets

Hou X; Kumar A; Lee C; Wang B; Arjunan P; Dong L; Maminishkis A; Tang Z; Li Y; Zhang F; Zhang S-Z; Wardega P; Chakrabarty S; Liu B; Wu Z; Colosi P; Fariss RN; Lennartsson J; Nussenblatt R; Gutkind JS; Cao Y; Li X
Article: CELL CYCLE. 2010;9(10):1882-1885

Cancer-associated retinopathy A new mechanistic insight on vascular remodeling

Cao R; Cao Y
Article: NATURE PROTOCOLS. 2010;5(5):912-920

Adipose angiogenesis: quantitative methods to study microvessel growth, regression and remodeling in vivo

Xue Y; Lim S; Brakenhielm E; Cao Y
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2010;207(4):867-880

Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3β phosphorylation

Tang Z; Arjunan P; Lee C; Li Y; Kumar A; Hou X; Wang B; Wardega P; Zhang F; Dong L; Zhang Y; Zhang S-Z; Ding H; Fariss RN; Becker KG; Lennartsson J; Nagai N; Cao Y; Li X
Article: DISCOVERY MEDICINE. 2010;9(46):179-184

Therapeutic Angiogenesis for Ischemic Disorders: What Is Missing for Clinical Benefits?

Cao Y
Article: CELL CYCLE. 2010;9(5):913-917

Pathological angiogenesis facilitates tumor cell dissemination and metastasis

Rouhi P; Lee SLC; Cao Z; Hedlund E-M; Jensen LD; Cao Y
Article: NATURE REVIEWS DRUG DISCOVERY. 2010;9(2):107-115

Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases

Cao Y
Article: SCIENCE TRANSLATIONAL MEDICINE. 2010;2(15):15ps3

Optimizing the Delivery of Cancer Drugs that Block Angiogenesis

Cao Y; Langer R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(2):856-861

VEGFR1-mediated pericyte ablation links VEGF and PlGF to cancer-associated retinopathy

Cao R; Xue Y; Hedlund E-M; Zhong Z; Tritsaris K; Tondelli B; Lucchini F; Zhu Z; Dissing S; Cao Y
Article: JOURNAL OF ANGIOGENESIS RESEARCH. 2009;1:9

Tumor-derived VEGF modulates hematopoiesis.

Xue Y; Chen F; Zhang D; Lim S; Cao Y
Article: PLOS ONE. 2009;4(11):e7867

Selective inhibition of retinal angiogenesis by targeting PI3 kinase.

Alvarez Y; Astudillo O; Jensen L; Reynolds AL; Waghorne N; Brazil DP; Cao Y; O'Connor JJ; Kennedy BN
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(46):19485-19490

Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model

Lee SLC; Rouhi P; Jensen LD; Zhang D; Ji H; Hauptmann G; Ingham P; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(43):18408-18413

Nitric oxide permits hypoxia-induced lymphatic perfusion by controlling arterial-lymphatic conduits in zebrafish and glass catfish

Jensen LDE; Cao R; Hedlund E-M; Soll I; Lundberg JO; Hauptmann G; Steffensen JF; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(41):17505-17510

Malignant cell-derived PlGF promotes normalization and remodeling of the tumor vasculature

Hedlund E-M; Hosaka K; Zhong Z; Cao R; Cao Y
Journal article: JOURNAL OF ANGIOGENESIS RESEARCH. 2009;1:1

Welcome to Journal of Angiogenesis Research.

Slevin M; Cao Y; Kitajewski J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(15):6152-6157

VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis

Zhang F; Tang Z; Hou X; Lennartsson J; Li Y; Koch AW; Scotney P; Lee C; Arjunan P; Dong L; Kumar A; Rissanen TT; Wang B; Nagai N; Fons P; Fariss R; Zhang Y; Wawrousek E; Tansey G; Raber J; Fong G-H; Ding H; Greenberg DA; Becker KG; Herbert J-M; Nash A; Yla-Herttuala S; Cao Y; Watts RJ; Li X
Article: CELL METABOLISM. 2009;9(1):99-109

Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation

Xue Y; Petrovic N; Cao R; Larsson O; Lim S; Chen S; Feldmann HM; Liang Z; Zhu Z; Nedergaard J; Cannon B; Cao Y
Article: FASEB JOURNAL. 2009;23(1):153-163

Differential roles of PDGFR-α and PDGFR-β in angiogenesis and vessel stability

Zhang J; Cao R; Zhang Y; Jia T; Cao Y; Wahlberg E
Article: FRONTIERS IN BIOSCIENCE-LANDMARK. 2009;14(10):3962-3973

Tumor angiogenesis and molecular targets for therapy

Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(47):18513-18518

Anti-VEGF agents confer survival advantages to tumor-bearing mice by improving cancer-associated systemic syndrome

Xue Y; Religa P; Cao R; Hansen AJ; Lucchini F; Jones B; Wu Y; Zhu Z; Pytowski B; Liang Y; Zhong W; Vezzoni P; Rozell B; Cao Y
Article: CIRCULATION RESEARCH. 2008;103(10):1092-1U71

Vascular Endothelial Growth Factor-A and Platelet-Derived Growth Factor-B Combination Gene Therapy Prolongs Angiogenic Effects via Recruitment of Interstitial Mononuclear Cells and Paracrine Effects Rather Than Improved Pericyte Coverage of Angiogenic Vessels

Korpisalo P; Karvinen H; Rissanen TT; Kilpijoki J; Marjomaki V; Baluk P; McDonald DM; Cao Y; Eriksson U; Alitalo K; Yla-Herttuala S
Article: CANCER RESEARCH. 2008;68(18):7293-7303

A novel gene expression profile in lymphatics associated with tumor growth and nodal metastasis

Clasper S; Royston D; Baban D; Cao Y; Ewers S; Butz S; Vestweber D; Jackson DG
Article: PLOS ONE. 2008;3(7):e2748

Hypoxia-Induced Retinal Angiogenesis in Zebrafish as a Model to Study Retinopathy

Cao R; Jensen LDE; Soell I; Hauptmann G; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(29):10167-10172

FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue

Xue Y; Cao R; Nilsson D; Chen S; Westergren R; Hedlund E-M; Martijn C; Rondahl L; Krauli P; Walum E; Enerback S; Cao Y
Article: JOURNAL OF CLINICAL INVESTIGATION. 2008;118(3):913-923

VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats

Li Y; Zhang F; Nagai N; Tang Z; Zhang S; Scotney P; Lennartsson J; Zhu C; Qu Y; Fang C; Hua J; Matsuo O; Fong G-H; Ding H; Cao Y; Becker KG; Nash A; Heldin C-H; Li X
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2008;37(3):507-518

Characterization of neuroprogenitor cells expressing the PDGF β-receptor within the subventricular zone of postnatal mice

Ishii Y; Matsumoto Y; Watanabe R; Elmi M; Fujimori T; Nissen J; Cao Y; Nabeshima Y-I; Sasahara M; Funa K
Article: METHODS IN MOLECULAR BIOLOGY. 2008;p. 65-81

Angiogenesis in adipose tissue.

Brakenhielm E; Cao Y
Article: JOURNAL OF CLINICAL INVESTIGATION. 2007;117(10):2766-2777

Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis

Nissen LJ; Cao R; Hedlund E-M; Wang Z; Zhao X; Wetterskog D; Funa K; Brakenhielm E; Cao Y
Article: BIOMEDICINE & PHARMACOTHERAPY. 2007;61(9):534-539

Tumor-derived lymphangiogenic factors and lymphatic metastasis

Cao Y; Zhong W
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(39):15364-15369

IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs

Tritsaris K; Myren M; Ditlev SB; Hubschmann MV; van der Blom I; Hansen AJ; Olsen UB; Cao R; Zhang J; Jia T; Wahlberg E; Dissing S; Cao Y
Article: EXPERIMENTAL CELL RESEARCH. 2007;313(13):2896-2909

Intra- and extracellular signaling by endothelial neuregulin-1

Iivanainen E; Paatero I; Heikkinen S-M; Junttila TT; Cao R; Klint P; Jaakkola PM; Cao Y; Elenius K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(29):12140-12145

Combinatorial protein therapy of angiogenic and arteriogenic factors remarkably improves collaterogenesis and cardiac function in pigs

Lu H; Xu X; Zhang M; Cao R; Brakenhielm E; Li C; Lin H; Yao G; Sun H; Qi L; Tang M; Dai H; Zhang Y; Su R; Bi Y; Zhang Y; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(10):3919-3924

Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development

Zhou X; Tian F; Sandzen J; Cao R; Flaberg E; Szekely L; Cao Y; Ohlsson C; Bergo MO; Boren J; Akyurek LM
Article: MOLECULAR AND CELLULAR BIOLOGY. 2006;26(12):4628-4641

Cell-type-specific regulation of degradation of hypoxia-inducible factor 1α:: Role of subcellular compartmentalization

Zheng X; Ruas JL; Cao R; Salomons FA; Cao Y; Poellinger L; Pereira T
Article: BLOOD. 2006;107(9):3531-3536

Hepatocyte growth factor is a lymphanoiogenic factor with an indirect mechanism of action

Cao RH; Björndahl MA; Gallego MI; Chen SH; Religa P; Hansen AJ; Cao YH
Article: GASTROENTEROLOGY. 2006;130(4):1301-1310

Gene transfer of kringle 1-5 suppresses tumor development and improves prognosis of mice with hepatocellular carcinoma

Torimura T; Ueno T; Kin M; Taniguchi E; Nakamura T; Inoue K; Sakata R; Hashimoto O; Sakamoto M; Ohira H; Kumashiro R; Sata M; Yano H; Kojiro M; Veitonmaki N; Cao YH
Article: BLOOD. 2005;106(13):4184-4190

Presence of bone marrow-derived circulating progenitor endothelial cells in the newly formed lymphatic vessels

Religa P; Cao RH; Bjorndahl M; Zhou ZJ; Zhu ZP; Cao YH
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(43):15593-15598

Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo.

Björndahl M; Cao R; Nissen LJ; Clasper S; Johnson LA; Xue Y; Zhou Z; Jackson D; Hansen AJ; Cao Y
Article: CANCER RESEARCH. 2005;65(20):9261-9268

Vascular endothelial growth factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasis

Björndahl MA; Cao R; Burton JB; Brakenhielm E; Religa P; Galter D; Wu L; Cao YH
Article: NATURE MEDICINE. 2005;11(7):780-785

Genomic instability in laminopathy-based premature aging

Liu BH; Wang JM; Chan KM; Tjia WM; Deng W; Guan XY; Huang JD; Li KM; Chau PY; Chen DJ; Pei DQ; Pendas AM; Cadiñanos J; López-Otín C; Tse HF; Hutchison C; Chen JJ; Cao YH; Cheah KSE; Tryggvason K; Zhou ZJ
Article: CELL CYCLE. 2005;4(2):228-230

Direct role of PDGF-BB in lymphangiogenesis and lymphatic metastasis.

Cao Y
Article: CANCER CELL. 2004;6(4):333-345

PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis

Cao RH; Björndahl MA; Religa P; Clasper S; Garvin S; Galter D; Meister B; Ikomi F; Tritsaris K; Dissing S; Ohhashi T; Jackson DG; Cao YH
Article: CANCER RESEARCH. 2004;64(14):4699-4702

Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient mice

Zhou ZJ; Wang JM; Cao RH; Morita H; Soininen R; Chan KM; Liu B; Cao YH; Tryggvason K
Article: CIRCULATION RESEARCH. 2004;94(12):1579-1588

Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice

Bråkenhielm E; Cao RH; Gao BH; Angelin B; Cannon B; Parini P; Cao YH
Article: CANCER RESEARCH. 2004;64(12):4059-4063

Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice

Zhou ZJ; Doi M; Wang JM; Cao RH; Liu BH; Chan KM; Kortesmaa J; Sorokin L; Cao YH; Tryggvason K
Article: CIRCULATION RESEARCH. 2004;94(11):1443-1450

Blockage of VEGF-induced angiogenesis by preventing VEGF secretion

Björndahl M; Cao RH; Eriksson A; Cao YH
Article: CANCER RESEARCH. 2004;64(10):3679-3686

Endothelial cell surface ATP synthase-triggered caspase-apoptotic pathway is essential for K1-5-Induced antiangiogenesis

Veitonmäki N; Cao R; Wu LH; Moser TL; Li B; Pizzo SV; Boris ZY; Cao YH
Article: SEMINARS IN CANCER BIOLOGY. 2004;14(2):139-145

Antiangiogenic cancer therapy.

Cao Y
Article: CIRCULATION RESEARCH. 2004;94(5):664-670

Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeability

Cao RH; Eriksson A; Kubo H; Alitalo K; Cao YH; Thyberg J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(8):2476-2481

Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis

Bråkenhielm E; Veitonmäki N; Cao RH; Kihara S; Matsuzawa YJ; Zhivotovsky B; Funahashi T; Cao YH
Article: SEMINARS IN THROMBOSIS AND HEMOSTASIS. 2004;30(1):83-93

Angiostatin.

Cao Y; Xue L
Journal article: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2003;1(5):s175

579 Significant tumor growth inhibition of glioblastoma xenografts by NNC 47-0011 — a low molecular weight tricyclic tyrosine kinase modulator with anti-angiogenic activity

Cao R; Cao Y; Dissing S; Hansen AJ; Kristjansen PEG; Olsen UB
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(10):6033-6038

Deletion of neuropeptide Y (NPY) 2 receptor in mice results in blockage of NPY-induced angiogenesis and delayed wound healing

Ekstrand AJ; Cao RH; Björndahl M; Nyström S; Jönsson-Rylander AC; Hassani H; Hallberg B; Nordlander M; Cao YH
Article: NATURE MEDICINE. 2003;9(5):604-613

Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2

Cao RH; Bråkenhielm E; Pawliuk R; Wariaro D; Post MJ; Wahlberg E; Leboulch P; Cao YH
Article: FASEB JOURNAL. 2003;17(2):764-766

Immortalization of bovine capillary endothelial cells by hTERT alone involves inactivation of endogenous p16^INK4A/pRb

Veitonmäki N; Fuxe J; Hultdin M; Roos G; Pattersson RF; Cao Y
Article: CIRCULATION. 2003;107(11):1532-1538

Small GTP-binding protein Rac is an essential mediator of vascular endothelial growth factor-induced endothelial fenestrations and vascular permeability

Eriksson A; Cao RH; Roy J; Tritsaris K; Wahlestedt C; Dissing S; Thyberg J; Cao YH
Article: ARTHRITIS RESEARCH & THERAPY. 2003;5(1):r32-R39

The angiogenesis inhibitor protease-activated kringles 1-5 reduces the severity of murine collagen-induced arthritis.

Sumariwalla PF; Cao Y; Wu H-L; Feldmann M; Paleolog EM
Article: NEUROSCIENCE. 2003;120(4):951-960

Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury

Widenfalk J; Lipson A; Jubran M; Hofstetter C; Ebendal T; Cao Y; Olson L
Article: FASEB JOURNAL. 2002;16(12):1575-1583

Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-αα and -αβ receptors

Cao RH; Bråkenhielm E; Li XR; Pietras K; Widenfalk J; Östman A; Eriksson U; Cao YH
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(13):8868-8873

Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea.

Kubo H; Cao R; Brakenhielm E; Mäkinen T; Cao Y; Alitalo K
Article: MOLECULAR THERAPY. 2002;5(4):345-351

Continuous intravascular secretion of endostatin in mice from transduced hematopoietic stem cells

Pawliuk R; Bachelot T; Zurkiya O; Eriksson A; Cao YH; Leboulch P
Article: MOLECULAR AND CELLULAR BIOLOGY. 2002;22(4):1194-1202

Deletion of the laminin α4 chain leads to impaired microvessel maturation

Thyboll J; Kortesmaa J; Cao RH; Soininen R; Wang L; Iivanainen A; Sorokin L; Risling M; Cao YH; Tryggvason K
Article: CANCER CELL. 2002;1(1):99-108

Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers

Eriksson A; Cao RH; Pawliuk R; Berg SM; Tsang M; Zhou D; Fleet C; Tritsaris K; Dissing S; Leboulch P; Cao YH
Article: LABORATORY INVESTIGATION. 2001;81(12):1669-1681

Embryonic stem cell-derived embryoid bodies development in collagen gels recapitulates sprouting angiogenesis.

Feraud O; Cao Y; Vittet D
Article: NATURE. 2001;414(6863):550-554

Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

Makino Y; Cao RH; Svensson K; Bertilsson GR; Åsman M; Tanaka H; Cao YH; Berkenstam A; Poellinger L
Article: ONCOGENE. 2001;20(34):4685-4695

The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor.

Ambartsumian N; Klingelhöfer J; Grigorian M; Christensen C; Kriajevska M; Tulchinsky E; Georgiev G; Berezin V; Bock E; Rygaard J; Cao R; Cao Y; Lukanidin E
Article: FASEB JOURNAL. 2001;15(10):1798-1800

Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes.

Bråkenhielm E; Cao R; Cao Y
Article: CIRCULATION. 2001;104(3):358-364

Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect

Aase K; von Euler G; Li X; Pontén A; Thorén P; Cao R; Cao Y; Olofsson B; Gebre-Medhin S; Pekny M; Alitalo K; Betsholtz C; Eriksson U
Article: CANCER RESEARCH. 2001;61(14):5441-5446

Effects of angiostatin gene transfer on functional properties and in vivo growth of Kaposi's sarcoma cells.

Indraccolo S; Morini M; Gola E; Carrozzino F; Habeler W; Minghelli S; Santi L; Chieco-Bianchi L; Cao Y; Albini A; Noonan DM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(11):6390-6395

Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF

Cao RH; Brakenhielm E; Wahlestedt C; Thyberg J; Cao YH
Article: MOLECULAR THERAPY. 2001;3(2):186-196

Combination angiostatin and endostatin gene transfer induces synergistic antiangiogenic activity in vitro and antitumor efficacy in leukemia and solid tumors in mice

Scappaticci FA; Smith R; Pathak A; Schloss D; Lum B; Cao YH; Johnson F; Engleman EG; Nolan GP
Article: ANGIOGENESIS. 2001;4(4):263-268

Statin-AE: a novel angiostatin-endostatin fusion protein with enhanced antiangiogenic and antitumor activity.

Scappaticci FA; Contreras A; Smith R; Bonhoure L; Lum B; Cao Y; Engleman EG; Nolan GP
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(38):29383-29390

Human plasmin enzymatic activity is inhibited by chemically modified dextrans.

Ledoux D; Papy-Garcia D; Escartin Q; Sagot MA; Cao Y; Barritault D; Courtois J; Hornebeck W; Caruelle JP
Journal article: GENE THERAPY AND REGULATION. 2000;1(2):123-139

Antiangiogenic gene therapy

Cao Y
Article: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2000;5(5):547-551

Elevated levels of urine angiostatin and plasminogen/plasmin in cancer patients

Cao YH; Veitonmäki N; Keough K; Cheng H; Lee LS; Cao YM; Zurakowski D
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(8):4052-4057

Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I

Zhou ZJ; Apte SS; Soininen R; Cao RH; Baaklini GY; Rauser RW; Wang JM; Cao YH; Tryggvason K
Article: FASEB JOURNAL. 1999;13(15):2195-2202

Interleukin-18 acts as an angiogenesis and tumor suppressor.

Cao R; Farnebo J; Kurimoto M; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(10):5728-5733

Suppression of angiogenesis and tumor growth by the inhibitor K1-5 generated by plasmin-mediated proteolysis

Cao RH; Wu HL; Veitonmäki N; Linden P; Farnebo J; Shi GY; Cao YH
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(19):13338-13344

Systemic gene delivery expands the repertoire of effective antiangiogenic agents

Liu Y; Thor A; Shtivelman E; Cao YH; Tu GH; Heath TD; Debs RJ
Article: AIDS. 1999;13(11):A5-A9

IAS position paper on prevention of HIV1 mother-to-child transmission

Hirsch MS; Wilfert C; Ammann A; Coovadia HM; Cu-Uvin S; Dabis F; Ekpini RAE; Kallings LO; Mofenson L; Tess B; Bryson Y; Cao Y; Chotpitayasunondh T; Nduati R; Solomon S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(24):14389-14394

Vascular endothelial growth factor C induces angiogenesis in vivo

Cao YH; Linden P; Farnebo J; Cao RH; Eriksson A; Kumar V; Qi JH; Claesson-Welsh L; Alitalo K
Article: LABORATORY INVESTIGATION. 1998;78(8):1029-1030

Microbead assay: a novel assay that detects endothelial cell proliferation and inhibition.

Cao Y; Ji RW; Folkman J
Article: CANCER RESEARCH. 1998;58(15):3362-3369

Viral vector-targeted antiangiogenic gene therapy utilizing an angiostatin complementary DNA.

Tanaka T; Cao Y; Folkman J; Fine HA
Article: JOURNAL OF CLINICAL INVESTIGATION. 1998;101(5):1055-1063

Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases.

Cao Y; O'Reilly MS; Marshall B; Flynn E; Ji RW; Folkman J
Article: ONCOGENE. 1998;16(3):359-367

Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C-gamma and migration of endothelial cells expressing Flt 1.

Landgren E; Schiller P; Cao Y; Claesson-Welsh L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(36):22924-22928

Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth

Cao YH; Chen A; An SSA; Ji RWD; Davidson D; Cao YM; Llinas M
Article: EMBO JOURNAL. 1997;16(13):3898-3911

Proteolytic processing regulates receptor specificity and activity of VEGF-C

Joukov V; Sorsa T; Kumar V; Jeltsch M; ClaessonWelsh L; Cao YH; Saksela O; Kalkkinen N; Alitalo K
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1997;235(3):493-498

Placenta growth factor: identification and characterization of a novel isoform generated by RNA alternative splicing.

Cao Y; Ji WR; Qi P; Rosin A; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1997;94(3):861-866

Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways.

Arbiser JL; Moses MA; Fernandez CA; Ghiso N; Cao Y; Klauber N; Frank D; Brownlee M; Flynn E; Parangi S; Byers HR; Folkman J
Article: JOURNAL OF CLINICAL INVESTIGATION. 1996;98(11):2507-2511

In vivo angiogenic activity and hypoxia induction of heterodimers of placenta growth factor/vascular endothelial growth factor.

Cao Y; Linden P; Shima D; Browne F; Folkman J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(46):29461-29467

Kringle domains of human angiostatin. Characterization of the anti-proliferative activity on endothelial cells.

Cao Y; Ji RW; Davidson D; Schaller J; Marti D; Söhndel S; McCance SG; O'Reilly MS; Llinás M; Folkman J
Article: SCIENCE. 1996;273(5274):510-513

Spinal cord repair in adult paraplegic rats: Partial restoration of hind limb function

Cheng H; Cao YH; Olson L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(6):3154-3162

Heterodimers of placenta growth factor/vascular endothelial growth factor. Endothelial activity, tumor cell expression, and high affinity binding to Flk-1/KDR.

Cao Y; Chen H; Zhou L; Chiang MK; Anand-Apte B; Weatherbee JA; Wang Y; Fang F; Flanagan JG; Tsang ML
Article: BRAIN RESEARCH. 1996;707(1):81-87

Distribution of acidic fibroblast growth factor-like immunoreactivity in rat skeletal muscle fibers

Junttila T; Rechardt L; Cao YH; Hokfelt T; PeltoHuikko M
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 1995;182(6):2069-2077

gro-beta, a -C-X-C- chemokine, is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice.

Cao Y; Chen C; Weatherbee JA; Tsang M; Folkman J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(20):9269-9273

The site of action of neuronal acidic fibroblast growth factor is the organ of Corti of the rat cochlea.

Pirvola U; Cao Y; Oellig C; Suoqiang Z; Pettersson RF; Ylikoski J
Journal article: NEUROSCIENCE. 1994;61(4):891-910

TEMPORAL AND SPATIAL INCREASE OF ASTROGLIAL BASIC FIBROBLAST GROWTH-FACTOR SYNTHESIS AFTER 6-HYDROXYDOPAMINE-INDUCED DEGENERATION OF THE NIGROSTRIATAL DOPAMINE NEURONS

CHADI G; CAO Y; PETTERSSON RF; FUXE K
Journal article: BRAIN RESEARCH. 1993;625(1):45-56

PHOTOCHEMICALLY INDUCED FOCAL CEREBRAL-ISCHEMIA IN RAT - TIME-DEPENDENT AND GLOBAL INCREASE IN EXPRESSION OF BASIC FIBROBLAST GROWTH-FACTOR MESSENGER-RNA

LIPPOLDT A; ANDBJER B; ROSEN L; RICHTER E; GANTEN D; CAO Y; PETTERSSON RF; FUXE K
Journal article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1993;5(10):1321-1333

GAP-43, AFGF, CCK AND ALPHA-CGRP AND BETA-CGRP IN RAT SPINAL MOTONEURONS SUBJECTED TO AXOTOMY AND OR DORSAL-ROOT SEVERANCE

PIEHL F; ARVIDSSON U; JOHNSON H; CULLHEIM S; DAGERLIND A; ULFHAKE B; CAO Y; ELDE R; PETTERSSON RF; TERENIUS L; HOKFELT T
Journal article: DEVELOPMENTAL BRAIN RESEARCH. 1993;75(1):65-73

FIBROBLAST GROWTH-FACTORS ENHANCE DOPAMINE FIBER FORMATION FROM NIGRAL GRAFTS

GIACOBINI MMJ; STROMBERG I; ALMSTROM S; CAO YH; OLSON L
Journal article: JOURNAL OF NEUROSCIENCE RESEARCH. 1993;35(4):419-427

PENTYLENETETRAZOL SEIZURES INCREASE PRO-NERVE GROWTH FACTOR-LIKE IMMUNOREACTIVITY IN THE RETICULAR THALAMIC NUCLEUS AND NERVE GROWTH-FACTOR MESSENGER-RNA IN THE DENTATE GYRUS

HUMPEL C; EBENDAL T; CAO Y; OLSON L
Journal article: JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY. 1993;41(4):521-533

BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) PEPTIDE ANTIBODIES - CHARACTERIZATION USING A VACCINIA VIRUS EXPRESSION SYSTEM

WETMORE CJ; CAO YH; PETTERSSON RF; OLSON L
Journal article: GROWTH FACTORS. 1993;8(4):277-290

Release and subcellular localization of acidic fibroblast growth factor expressed to high levels in HeLa cells.

Cao Y; Pettersson RF
Journal article: JOURNAL OF CELL SCIENCE. 1993;104:77-87

CHARACTERIZATION OF THE NUCLEAR TRANSLOCATION OF ACIDIC FIBROBLAST GROWTH-FACTOR

CAO Y; EKSTROM M; PETTERSSON RF
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1991;88(22):10237-10241

EXPRESSION OF ACIDIC AND BASIC FIBROBLAST GROWTH-FACTORS IN THE SUBSTANTIA-NIGRA OF RAT, MONKEY, AND HUMAN

BEAN AJ; ELDE R; CAO YH; OELLIG C; TAMMINGA C; GOLDSTEIN M; PETTERSSON RF; HOKFELT T
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1991;88(21):9843-9847

BRAIN-DERIVED NEUROTROPHIC FACTOR - SUBCELLULAR COMPARTMENTALIZATION AND INTERNEURONAL TRANSFER AS VISUALIZED WITH ANTIPEPTIDE ANTIBODIES

WETMORE C; CAO YH; PETTERSSON RF; OLSON L
Journal article: NEUROREPORT. 1991;2(10):597-600

BASIC FGF IS PRESENT IN DOPAMINERGIC-NEURONS OF THE VENTRAL MIDBRAIN OF THE RAT

CINTRA A; CAO YH; OELLIG C; TINNER B; BORTOLOTTI F; GOLDSTEIN M; PETTERSSON RF; FUXE K
Journal article: NEURON. 1991;7(3):349-364

PROMINENT EXPRESSION OF ACIDIC FIBROBLAST GROWTH-FACTOR IN MOTOR AND SENSORY NEURONS

ELDE R; CAO Y; CINTRA A; BRELJE TC; PELTOHUIKKO M; JUNTTILA T; FUXE K; PETTERSSON RF; HOKFELT T
Journal article: GROWTH FACTORS. 1990;3(1):1-13

Human acidic fibroblast growth factor overexpressed in insect cells is not secreted into the medium.

Cao YH; Pettersson RF
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All other publications

Editorial comment: CHINESE MEDICAL JOURNAL. 2024;137(6):636-637

Angiogenesis in diseases: A half-century excursion from the initial therapeutic concept to current clinical benefits

Cao Y
Review: NATURE REVIEWS DRUG DISCOVERY. 2023;22(6):476-495

Targeting angiogenesis in oncology, ophthalmology and beyond

Cao Y; Langer R; Ferrara N
Editorial comment: CHINESE MEDICAL JOURNAL. 2022;135(22):2647-2652

Blood vessels in fat tissues and vasculature-derived signals in controlling lipid metabolism and metabolic disease

Cao Y
Preprint: RESEARCH SQUARE. 2022

New splice variants of VEGF as relevant targets for the treatment of renal cell carcinoma

Montemagno C; Durivault J; Gastaldi C; Dufies M; Vial V; He X; Ambrosetti D; Kamenskaya A; Négrier S; Bernhard JC; Borchiellini D; Cao Y; Pagès G
Review: NATURE MEDICINE. 2022;28(11):2273-2287

The landscape of mRNA nanomedicine

Huang X; Kong N; Zhang X; Cao Y; Langer R; Tao W
Corrigendum: NATURE METABOLISM. 2022;4(10):1421

Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome (June, 10.1038/s42255-022-00593-x, 2022)

Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
Preprint: RESEARCH SQUARE. 2022

New splice variants of VEGF as relevant targets for the treatment of Renal Cell Carcinoma

Montemagno C; Durivault J; Gastaldi C; Dufies M; Vial V; He X; Ambrosetti D; Négrier S; Bernhard J-C; Borchiellini D; Cao Y; Pagès G
Review: NATURE REVIEWS CARDIOLOGY. 2022;19(4):228-249

Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis

Chen W; Schilperoort M; Cao Y; Shi J; Tabas I; Tao W
Editorial comment: JOURNAL OF CLINICAL INVESTIGATION. 2021;131(20):e153448

Lymphatics in the broken heart

Brakenhielm E; Chen Y; Cao Y
Preprint: BIORXIV. 2020

Pulmonary stromal expansion and intra-alveolar coagulation are primary causes of Covid-19 death

Szekely L; Bozoky B; Bendek M; Ostad M; Lavignasse P; Haag L; Wu J; Jing X; Gupta S; Saccon E; Sönnerborg A; Cao Y; Björnstedt M; Szakos A
Preprint: MEDRXIV. 2020

A novel mechanism of HIF2-dependent PLK1-mediated metastasis and drug resistance of clear cell Renal Cell Carcinoma

Dufies M; Verbiest A; Cooley LS; Ndiaye PD; Viotti J; He X; Nottet N; Souleyreau W; Hagege A; Torrino S; Parola J; Giuliano S; Borchiellini D; Schiappa R; Mograbi B; Zucman-Rossi J; Bensalah K; Ravaud A; Auberger P; Bikfalvi A; Chamorey E; Rioux-Leclercq N; Mazure NM; Beuselinck B; Cao Y; Bernhard JC; Ambrosetti D; Pagès G
Review: NATURE REVIEWS MATERIALS. 2020;5(11):847-860

A materials-science perspective on tackling COVID-19

Tang Z; Kong N; Zhang X; Liu Y; Hu P; Mou S; Liljestrom P; Shi J; Tan W; Kim JS; Cao Y; Langer R; Leong KW; Farokhzad OC; Tao W
Editorial comment: JOURNAL OF EXPERIMENTAL MEDICINE. 2019;216(8):1730-1732

Endothelial life discontinues without Erk

Cao Y
Review: JOURNAL OF CLINICAL INVESTIGATION. 2019;129(8):3006-3017

Adipocyte and lipid metabolism in cancer drug resistance

Cao Y
Conference publication: ANGIOGENESIS. 2019;22(4):600

Decreased expression of VEGFR1 contributes to the pathogenesis of hereditary hemorrhagic telangiectasia type 2

Thalgott J; Dos-Santos-Luis D; Hosman A; Martin S; Lamande N; Bracquart D; Srun S; Galaris G; de Boer H; Tual-Chalot S; Kroon S; Arthur H; Cao Y; Snijder R; Disch F; Mager J; Rabelink T; Mummery C; Raymond K; Lebrin F
Editorial comment: CELL METABOLISM. 2018;27(6):1163-1165

Obesity Protects Cancer from Drugs Targeting Blood Vessels

Cao Y
Conference publication: INTERNATIONAL JOURNAL OF UROLOGY. 2018;25:308

Off tumor targets compromise antiangiogenic drug sensitivity by inducing kidney erythropoietin production

Nakamura M; Cao Y; Homma Y
Book chapter: ANGIOGENESIS-BASED DERMATOLOGY. 2017;p. 1-26

Angiogenesis: General Concepts

Jensen L; Cao Y
Conference publication: CANCER RESEARCH. 2016;76:3933

CETSA as a diagnostic tool to guide personalized breast cancer therapy

Oeberg A; Laursen H; Packham S; Molina DM; Seki T; Cao Y; Hartman J; Bergh J; Nordlund P; Loeoef S
Review: CHINESE JOURNAL OF CANCER. 2016;35:21-9

Future options of anti-angiogenic cancer therapy

Cao Y
Review: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. 2015;30(5):689-721

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium

Pettersen EO; Ebbesen P; Gieling RG; Williams KJ; Dubois L; Lambin P; Ward C; Meehan J; Kunkler IH; Langdon SP; Ree AH; Flatmark K; Lyng H; Calzada MJ; del Peso L; Landazuri MO; Goerlach A; Flamm H; Kieninger J; Urban G; Weltin A; Singleton DC; Haider S; Buffa FM; Harris AL; Scozzafava A; Supuran CT; Moser I; Jobst G; Busk M; Toustrup K; Overgaard J; Alsner J; Pouyssegur J; Chiche J; Mazure N; Marchiq I; Parks S; Ahmed A; Ashcroft M; Pastorekova S; Cao Y; Rouschop KM; Wouters BG; Koritzinsky M; Mujcic H; Cojocari D
Editorial comment: ONCOIMMUNOLOGY. 2015;4(3):e989777

Collaborative effects between the TNFα-TNFR1-macrophage axis and the VEGF-C-VEGFR3 signaling in lymphangiogenesis and metastasis

Cao R; Ji H; Yang Y; Cao Y
Book chapter: HANDBOOK OF VASCULAR BIOLOGY TECHNIQUES. 2015;p. 221-229

Adipose Angiogenesis

Fischer C; Lim S; Honek J; Cao Y
Book chapter: HANDBOOK OF VASCULAR BIOLOGY TECHNIQUES. 2015;p. 195-207

Methods for Studying Developmental Angiogenesis in Zebrafish

Ali Z; Wang J; Cao Y; Jensen LD
Review: NATURE REVIEWS ENDOCRINOLOGY. 2014;10(9):530-539

VEGF-targeted cancer therapeutics - paradoxical effects in endocrine organs

Cao Y
Review: HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION. 2014;19(1):5-11

Brown adipose tissue, thermogenesis, angiogenesis: pathophysiological aspects.

Honek J; Lim S; Fischer C; Iwamoto H; Seki T; Cao Y
Review: CHEMICAL IMMUNOLOGY AND ALLERGY. 2014;99:170-179

Angiogenesis as a therapeutic target for obesity and metabolic diseases.

Cao Y
Review: CELL METABOLISM. 2013;18(4):478-489

Angiogenesis and Vascular Functions in Modulation of Obesity, Adipose Metabolism, and Insulin Sensitivity

Cao Y
Review: TRENDS IN MOLECULAR MEDICINE. 2013;19(8):460-473

Multifarious functions of PDGFs and PDGFRs in tumor growth and metastasis

Cao Y
Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2013;24(4):190-199

Erythropoietin in cancer: a dilemma in risk therapy

Cao Y
Conference publication: CANCER RESEARCH. 2013;73:b90

Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model

Rouhl P; Lee SL; Jensen LD; Zhang D; Ji H; Hauptmann G; Ingham P; Cao Y
Book chapter: ANGIOGENESIS IN ADIPOSE TISSUE. 2013;p. 187-228

Leptin, Adiponectin, and Other Adipokines in Regulation of Adipose Tissue Angiogenesis

Brakenhielm E; Cao Y
Book chapter: THE TEXTBOOK OF ANGIOGENESIS AND LYMPHANGIOGENESIS: METHODS AND APPLICATIONS. 2012;p. 85-99

Quantitative Methods to Study Adipose Angiogenesis

Lim S; Honek J; Cao Z; Seki T; Xue Y; Cao Y
Book chapter: MOLECULAR AND TRANSLATIONAL VASCULAR MEDICINE: MOLECULAR AND TRANSLATIONAL MEDICINE. 2012;p. 207-226

Therapeutic Angiogenesis for Critical Limb Ischemia: Complex Mechanisms and Future Challenges

Cao Y
Review: SCIENCE TRANSLATIONAL MEDICINE. 2011;3(114):114rv3

Forty-Year Journey of Angiogenesis Translational Research

Cao Y; Arbiser J; D'Amato RJ; D'Amore PA; Ingber DE; Kerbel R; Klagsbrun M; Lim S; Moses MA; Zetter B; Dvorak H; Langer R
Review: BIRTH DEFECTS RESEARCH PART C - EMBRYO TODAY: REVIEWS. 2011;93(2):182-193

Zebrafish Models to Study Hypoxia-Induced Pathological Angiogenesis in Malignant and Nonmalignant Diseases

Jensen LD; Rouhi P; Cao Z; Lanne T; Wahlberg E; Cao Y
Conference publication: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2010;8(7):153

The selective alpha5beta1 integrin antagonist, CLT-28643, inhibits tumors angiogenesis and growth

Caldirola P; Backman U; Cao Y
Review: EXPERIMENTAL CELL RESEARCH. 2010;316(8):1304-1308

Angiogenesis: What can it offer for future medicine?

Cao Y
Meeting abstract: GUT. 2010;59:A112

COLORECTAL CANCER LYMPHATICS DISPLAY AN ALTERED PHENOTYPE ASSOCIATED WITH LYMPH NODE METASTASIS

Royston DJ; Clasper S; Baban D; Cao Y; Jackson DG
Editorial comment: BLOOD. 2010;115(12):2336-2337

Wake-up call for endothelial cells

Cao Y
Book chapter: THERAPEUTIC ANGIOGENESIS FOR VASCULAR DISEASES. 2010;p. 95-113

Cancer Therapy by Targeting Vascular Endothelial Cell Growth Factor- and Non-Vascular Endothelial Cell Growth Factor-Mediated Angiogenesis

Cao Y
Review: CURRENT MOLECULAR MEDICINE. 2009;9(8):982-991

In Vivo Angiogenesis and Lymphangiogenesis Models

Jensen LD; Cao R; Cao Y
Review: CURRENT MOLECULAR MEDICINE. 2009;9(8):967-972

Monotherapy Versus Combination Therapy of Angiogenic and Arteriogenic Factors for the Treatment of Ischemic Disorders

Cao Y
Editorial comment: CURRENT MOLECULAR MEDICINE. 2009;9(8):928

Hot topic: Angiogenesis and Lymphangiogenesis in Common Diseases

Cao Y
Editorial comment: SEMINARS IN CANCER BIOLOGY. 2009;19(5):277-278

Angiogenesis in malignancy

Cao Y
Review: SEMINARS IN CANCER BIOLOGY. 2009;19(5):338-343

Improvement of antiangiogenic cancer therapy by understanding the mechanisms of angiogenic factor interplay and drug resistance

Cao Y; Zhong W; Sun Y
Review: SCIENCE SIGNALING. 2009;2(59):re1

Positive and Negative Modulation of Angiogenesis by VEGFR1 Ligands

Cao Y
Other: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(36):13203-13205

A review of Judah Folkman's remarkable achievements in biomedicine

Cao Y; Langer R
Review: JOURNAL OF MOLECULAR MEDICINE-JMM. 2008;86(7):785-789

R Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathways

Cao Y; Cao R; Hedlund E-M
Review: CLINICAL LIPIDOLOGY. 2008;3(2):153-162

Therapeutic potential of antiangiogenic agents for prevention and treatment of obesity

Cao Y; Cao R; Xue Y
Review: LYMPHATIC RESEARCH AND BIOLOGY. 2008;6(3-4):145-148

Why and how do tumors stimulate lymphangiogenesis?

Cao Y
Review: MECHANISMS AND THERAPY OF LIVER CANCER. 2008;100:113-131

Molecular mechanisms and therapeutic development of angiogenesis inhibitors

Cao Y
Review: JOURNAL OF CLINICAL INVESTIGATION. 2007;117(9):2362-2368

Angiogenesis modulates adipogenesis and obesity

Cao Y
Conference publication: TISSUE ENGINEERING. 2007;13(7):1695

Factors influencing angiogenic processes in the VascuPlug unit: Analysis of neovascularisation

Hiebl B; Cao Y; Knedlitschek G
Review: MECHANISMS AND THERAPY OF LIVER CANCER. 2007;97:203-224

Therapeutic targets of multiple angiogenic factors for the treatment of cancer and metastasis

Cao Y; Liu Q
Review: BRITISH JOURNAL OF CANCER. 2006;95(12):1611-1625

First international consensus on the methodology of lymphangiogenesis quantification in solid human tumours

Van der Auwera I; Cao Y; Tille JC; Pepper MS; Jackson DG; Fox SB; Harris AL; Dirix LY; Vermeulen PB
Editorial comment: BLOOD. 2006;108(8):2506-2507

VEGF calls its receptors from the recycling compartment

Cao Y
Corrigendum: CANCER CELL. 2006;9(3):239

PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis (vol 6, pg 333, 2004)

Cao RH; Björndahl MA; Religa P; Clasper S; Garvin S; Gaiter D; Meister B; Ikomi F; Tritsoris K; Dissing S; Ohhashi T; Jackson DG; Cao YH
Book chapter: CELL BIOLOGY. 2006;p. 373-378

Chapter 46 Angiogenesis Assays

Cao Y
Book chapter: RESVERATROL IN HEALTH AND DISEASE. 2005;p. 149-165

Resveratrol as an Angiogenesis Inhibitor

Bråkenhielm E; Cao R; Cao Y
Book chapter: RESVERATROL IN HEALTH AND DISEASE: OXIDATIVE STRESS AND DISEASE. 2005;p. 149-165

Resveratrol as an Angiogenesis Inhibitor

Cao R; Cao Y; Brakenhielm E
Published conference paper: BIOMEDICINE & PHARMACOTHERAPY. 2005;59:S340-S343

Tumor angiogenesis and therapy

Cao Y
Review: NATURE REVIEWS CANCER. 2005;5(9):735-743

Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis.

Cao Y
Review: CARDIOVASCULAR RESEARCH. 2005;65(3):639-648

Update on therapeutic neovascularization.

Cao Y; Hong A; Schulten H; Post MJ
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2005;124(4):A4

IL-20 is an angiogenic factor in psoriasis

Hansen A; Cao R; Cao Y; Clausen JT; Dissing S; Hasselager E; Myren M; Norby PL; Olsen UB; Tritsaris K
Book chapter: THE NPY FAMILY OF PEPTIDES IN IMMUNE DISORDERS, INFLAMMATION, ANGIOGENESIS AND CANCER: PROGRESS IN INFLAMMATION RESEARCH. 2005;p. 167-174

NPY-induced angiogenesis in retinopathy and wound healing

Björndahl M; Cao R; Xue L; Cao Y
Corrigendum: CIRCULATION RESEARCH. 2004;95(10):e83-e84

Blockage of VEGF-induced angiogenesis by preventing VEG secretion (vol 94, pg 1443, 2004)

Björndahl
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2003;532:109-120

Angiogenesis inhibitors and their therapeutic potentials.

Yihai C
Review: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. 2002;2(6):667-681

Kringle structures and antiangiogenesis.

Cao Y; Cao R; Veitonmäki N
Review: JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 2002;13(7):380-390

Antiangiogenic mechanisms of diet-derived polyphenols.

Cao Y; Cao R; Bråkenhielm E
Review: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2001;33(4):357-369

Endogenous angiogenesis inhibitors and their therapeutic implications.

Cao Y
Published conference paper: HAEMATOLOGICA. 1999;84(7):643-650

Therapeutic potentials of angiostatin in the treatment of cancer.

Cao Y
Letter: NATURE. 1999;398(6726):381

Angiogenesis inhibited by drinking tea.

Cao Y; Cao R
Conference publication: BLOOD. 1999;94(10):420B

Antiangiogenic gene therapy of murine B16F10 melanoma and L1210 leukemia tumors with angiostatin and endostatin containing MMuLV retroviral vectors.

Scappaticci FA; Smith R; Schloss D; Cao Y; Engleman EG; Nolan GP; Leung L
Review: PROGRESS IN MOLECULAR AND SUBCELLULAR BIOLOGY. 1998;20:161-176

Endogenous angiogenesis inhibitors: angiostatin, endostatin, and other proteolytic fragments.

Cao Y
Book chapter: TROPHIC REGULATION OF THE BASAL GANGLIA. 1994;p. 267-284

18 Acidic and Basic Fibroblast Growth Factors are Present in, and Produce Effects upon, Mesencephalic Dopamine Neurons

BEAN AJ; ELDE R; OELLIG C; CAO Y; PETTERSSON RF; HÖKFELT T
Book chapter: TROPHIC REGULATION OF THE BASAL GANGLIA. 1994;p. 151-165

9 Localization of Neurotrophins and Their Receptors at the mRNA and Protein Level

OLSON L; WETMORE C; BEAN AJ; CAO Y; PETTERSSON RF
Book chapter: TROPHIC REGULATION OF THE BASAL GANGLIA. 1994;p. 1-41

1 Fibroblast Growth Factor-2, Ganglioside GM1 and the Trophic Regulation of the Basal Ganglia. Focus on the Nigrostriatal Dopamine Neurons

FUXE K; CHADI G; AGNATI LF; TINNER B; ROSÉN L; JANSON AM; MØLLER A; CINTRA A; CAO Y; GOLDSTEIN M; LINDAHL U; DAVID G; ÖGREN SO; TOFFANO G; BAIRD A; PETTERSSON RF
Conference publication: JOURNAL OF CELLULAR BIOCHEMISTRY. 1993;:280

LOCALIZATION OF OVEREXPRESSED AFGF IN SENSORY AND MOTOR NEURONS IN CULTURES OF RAT DORSAL-ROOT GANGLIA AND VENTRAL ROOTS

OELLIG C; TAYLOR L; LILJESTROM P; CAO YH; PETTERSSON R
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Grants

Implementation of a zebrafish cancer model in diagnosis of human cancer invasion and prediction of drug responses

Swedish Research Council

1 January 2022 - 31 December 2024
Induce vascular networks in large degradable porous scaffolds by influencing the local microenvironment; spatiotemporal control of growth factors and patterning of mechanical signals

Swedish Research Council

1 January 2021 - 31 December 2024
Interdisciplinary framework on the role of adaptive cellular immunity in SARS-CoV-2 protection

Swedish Research Council

1 January 2021 - 31 December 2023
Mechanistic study of the vasculature-modulated tumor microenvironment in tumor growth, metastasis and drug responses

Swedish Research Council

1 January 2020 - 31 December 2024
Mechanistic and translational research on tumor angiogenesis

Swedish Cancer Society

1 January 2018
Mechanistic and translational research on tumor angiogenesis

Swedish Cancer Society

1 January 2017
Angiogenesis in diseases: mechanisms and therapeutic challenges

Swedish Research Council

1 January 2016 - 31 December 2019
Mechanisms and therapeutic challenges in tumor angiogenesis

Swedish Cancer Society

1 January 2016
Modulation of Adipose Angiogenesis: A New Concept of Treatment of Obesity, Diabetes and other Metabolic Disease

Novo Nordisk Foundation

1 January 2015 - 31 December 2019
Mechanisms and therapeutic challenges in tumor angiogenesis

Swedish Cancer Society

1 January 2015
Hitting cancer on target – Novel strategies for optimizing drug target engagement for improved brest cancer therapies

Knut and Alice Wallenberg Foundation

1 January 2014 - 1 January 2019
Mechanisms and therapeutic challenges in tumor angiogenesis

Swedish Cancer Society

1 January 2014
Cold-induced lipolysis and angiogenesis significantly contribute to development of cardiovascular disease

Novo Nordisk Foundation

29 August 2013 - 29 August 2014
Translational research on angiogenesis in diseases

Swedish Research Council

1 January 2012 - 31 December 2016
New mechanisms of angiogenesis modulators in switching between white and brown adipose tissues

European Research Council

1 March 2010 - 28 February 2015
Angiogenesis as a therapeutic target for non-malignant diseases

Swedish Research Council

1 January 2009 - 31 December 2011

Employments

Professor, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2004-

Degrees and Education

Docent, Karolinska Institutet, 1995

About me

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