Yihai Cao

About me
Publications
Grants
CV
Public outreach and news

About me

Professor of Vascular Biology, Cancer Research and Metabolic Research.

Research

Angiogenesis, Cancer, Metastasis, Metabolism, Disease Therapy, Cardiovascular Disease, Ophthalmologic Disease.

Teaching

Undergraduate Education
Graduate Education
Ph.D Education
Postdoctoral Training

Articles

Article: DIABETES. 2025;74(1):22-35
Long-term Nerve Regeneration in Diabetic Keratopathy Mediated by a Novel NGF Delivery System
Cong L; Qi B; Chen S; Liu R; Li S; Zhou Q; Cao Y; Zhang BN; Xie L
Article: ADVANCED SCIENCE. 2024;11(48):e2409726
Identification of ANXA1 as a Novel Upstream Negative Regulator of Notch1 Function in AML
Shao G; Wang X; Zheng Y; Ma J; Wang L; Yan Z; Sun Z; Zhang S; Wu H; Lv Y; Huang H; Li J; Zhu T; Yang B; Wang N; Chen T; Guo X; Jin Y; Kang J; Wang H; Cao Y; Fu C
Article: CELL DISCOVERY. 2024;10(1):106
NUMB dysfunction defines a novel mechanism underlying hyperuricemia and gout
Chi J; Chen Y; Li C; Liu S; Che K; Kong Z; Guo Z; Chu Y; Huang Y; Yang L; Sun C; Wang Y; Lv W; Zhang Q; Guo H; Zhao H; Yang Z; Xu L; Wang P; Dong B; Hu J; Liu S; Wang F; Zhao Y; Qi M; Xin Y; Nan H; Zhao X; Zhang W; Xiao M; Si K; Wang Y; Cao Y
Article: ADVANCED SCIENCE. 2024;11(38):e2402332
Effective Prevention and Treatment of Acute Leukemias in Mice by Activation of Thermogenic Adipose Tissues
Chen R; Cheng T; Xie S; Sun X; Chen M; Zhao S; Ruan Q; Ni X; Rao M; Quan X; Chen K; Zhang S; Cheng T; Xu Y; Chen Y; Yang Y; Cao Y
Article: REDOX BIOLOGY. 2024;76:103318
ALDH2 deficiency augments atherosclerosis through the USP14-cGAS-dependent polarization of proinflammatory macrophages
Rui H; Yu H; Chi K; Han Z; Zhu W; Zhang J; Guo H; Zou W; Wang F; Xu P; Zou D; Song X; Liu L; Wu X; Wu W; Qin D; Cao Y; Xu F; Xue L; Chen Y
Article: CELL DEATH AND DIFFERENTIATION. 2024;31(6):697-710
Proteinase 3 depletion attenuates leukemia by promoting myeloid differentiation
Liu H; Sun L; Zhao H; Zhao Z; Zhang S; Jiang S; Cheng T; Wang X; Wang T; Shao Y; Zhu H; Han H; Cao Y; Jiang E; Cao Y; Xu Y
Article: SCIENCE TRANSLATIONAL MEDICINE. 2024;16(747):eadi2952
Tumor-associated NK cells drive MDSC-mediated tumor immune tolerance through the IL-6/STAT3 axis
Neo SY; Tong L; Chong J; Liu Y; Jing X; Oliveira MMS; Chen Y; Chen Z; Lee K; Burduli N; Chen X; Gao J; Ma R; Lim JP; Huo J; Xu S; Alici E; Wickstrom SL; Haglund F; Hartman J; Wagner AK; Cao Y; Kiessling R; Lam KP; Westerberg LS; Lundqvist A
Article: CELLULAR & MOLECULAR IMMUNOLOGY. 2024;21(5):510-526
Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS
Xu C; Zhang L; Xu S; Wang Z; Han Q; Lv Y; Wang X; Zhang X; Zhang Q; Zhang Y; He S; Yuan Q; Bian Y; Li C; Wang J; Xu F; Cao Y; Pang J; Chen Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2024;121(6):e2305947121
Effective treatment of optic neuropathies by intraocular delivery of MSC-sEVs through augmenting the G-CSF- macrophage pathway
Yi W; Xue Y; Qing W; Cao Y; Zhou L; Xu M; Sun Z; Li Y; Mai X; Shi L; He C; Zhang F; Duh EJ; Cao Y; Liu X
Article: SCIENCE CHINA-LIFE SCIENCES. 2024;67(2):332-344
The role of corneal endothelium in macular corneal dystrophy development and recurrence
Zhang B-N; Qi B; Dong C; Zhang B; Cheng J; Wang X; Li S; Zhuang X; Chen S; Duan H; Li D; Zhu S; Li G; Cao Y; Zhou Q; Xie L
Article: FRONTIERS IN ENDOCRINOLOGY. 2024;15:1338147
New mechanistic insights of anti-obesity by sleeve gastrectomy-altered gut microbiota and lipid metabolism
Liu C; Xu Q; Dong S; Ding H; Li B; Zhang D; Liang Y; Li L; Liu Q; Cheng Y; Wu J; Zhu J; Zhong M; Cao Y; Zhang G
Article: HOLIST INTEGR ONCOL. 2024;3(1):11
Cancer-triggered systemic disease and therapeutic targets.
Cao Y
Article: NATURE COMMUNICATIONS. 2023;14(1):7610
Mirabegron displays anticancer effects by globally browning adipose tissues
Sun X; Sui W; Mu Z; Xie S; Deng J; Li S; Seki T; Wu J; Jing X; He X; Wang Y; Li X; Yang Y; Huang P; Ge M; Cao Y
Article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2023;62(41):e202308413
In situ Engineering of Tumor-Associated Macrophages via a Nanodrug-Delivering-Drug (β-Elemene@Stanene) Strategy for Enhanced Cancer Chemo-Immunotherapy
Chen W; Li Y; Liu C; Kang Y; Qin D; Chen S; Zhou J; Liu H-J; Ferdows BE; Patel DN; Huang X; Koo S; Kong N; Ji X; Cao Y; Tao W; Xie T
Journal article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2023;135(41)
Titelbild: In situ Engineering of Tumor‐Associated Macrophages via a Nanodrug‐Delivering‐Drug (β‐Elemene@Stanene) Strategy for Enhanced Cancer Chemo‐Immunotherapy (Angew. Chem. 41/2023)
Chen W; Li Y; Liu C; Kang Y; Qin D; Chen S; Zhou J; Liu H; Ferdows BE; Patel DN; Huang X; Koo S; Kong N; Ji X; Cao Y; Tao W; Xie T
Article: ADVANCED SCIENCE. 2023;10(28):e2301852
Deubiquitinase OTUD5 as a Novel Protector against 4-HNE-Triggered Ferroptosis in Myocardial Ischemia/Reperfusion Injury
Liu L; Pang J; Qin D; Li R; Zou D; Chi K; Wu W; Rui H; Yu H; Zhu W; Liu K; Wu X; Wang J; Xu P; Song X; Cao Y; Wang J; Xu F; Xue L; Chen Y
Article: SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2023;8(1):305
VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway
Lee C; Chen R; Sun G; Liu X; Lin X; He C; Xing L; Liu L; Jensen LD; Kumar A; Langer HF; Ren X; Zhang J; Huang L; Yin X; Kim J; Zhu J; Huang G; Li J; Lu W; Chen W; Liu J; Hu J; Sun Q; Lu W; Fang L; Wang S; Kuang H; Zhang Y; Tian G; Mi J; Kang B-A; Narazaki M; Prodeus A; Schoonjans L; Ornitz DM; Gariepy J; Eelen G; Dewerchin M; Yang Y; Ou J-S; Mora A; Yao J; Zhao C; Liu Y; Carmeliet P; Cao Y; Li X
Article: ADVANCED SCIENCE. 2023;10(24):e2301505
Disruption of the Clock Component Bmal1 in Mice Promotes Cancer Metastasis through the PAI-1-TGF-β-myoCAF-Dependent Mechanism
Wu J; Jing X; Du Q; Sun X; Holgersson K; Gao J; He X; Hosaka K; Zhao C; Tao W; FitzGerald GA; Yang Y; Jensen LD; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(29):e2303740120
KRAS mutation-driven angiopoietin 2 bestows anti-VEGF resistance in epithelial carcinomas
Hosaka K; Andersson P; Wu J; He X; Du Q; Jing X; Seki T; Gao J; Zhang Y; Sun X; Huang P; Yang Y; Ge M; Cao Y
Article: MOLECULAR ONCOLOGY. 2023;17(7):1379-1401
A group of novel VEGF splice variants as alternative therapeutic targets in renal cell carcinoma
Montemagno C; Durivault J; Gastaldi C; Dufies M; Vial V; He X; Ambrosetti D; Kamenskaya A; Negrier S; Bernhard J-C; Borchiellini D; Cao Y; Pages G
Article: ADVANCED SCIENCE. 2023;10(16):e2207439
Glutathione-Scavenging Nanoparticle-Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effects
Liu H-J; Chen W; Wu G; Zhou J; Liu C; Tang Z; Huang X; Gao J; Xiao Y; Kong N; Joshi N; Cao Y; Abdi R; Tao W
Article: CANCER COMMUNICATIONS. 2023;43(6):637-660
Perivascular localized cells commit erythropoiesis in PDGF-B-expressing solid tumors
Hosaka K; Wang C; Zhang S; Lv X; Seki T; Zhang Y; Jing X; Wu J; Du Q; He X; Fan Y; Li X; Kondo M; Yoshihara M; Qian H; Shi L; Zhu P; Xu Y; Yang Y; Cheng T; Cao Y
Journal article: CHINESE JOURNAL OF CANCER. 2023;43(4):i
Cover Image, Volume 43, Issue 4
Suzuki H; Iwamoto H; Seki T; Nakamura T; Masuda A; Sakaue T; Tanaka T; Imamura Y; Niizeki T; Nakano M; Shimose S; Shirono T; Noda Y; Kamachi N; Sakai M; Morita K; Nakayama M; Yoshizumi T; Kuromatsu R; Yano H; Cao Y; Koga H; Torimura T
Article: CANCER COMMUNICATIONS. 2023;43(4):415-434
Tumor-derived insulin-like growth factor-binding protein-1 contributes to resistance of hepatocellular carcinoma to tyrosine kinase inhibitors
Suzuki H; Iwamoto H; Seki T; Nakamura T; Masuda A; Sakaue T; Tanaka T; Imamura Y; Niizeki T; Nakano M; Shimose S; Shirono T; Noda Y; Kamachi N; Sakai M; Morita K; Nakayama M; Yoshizumi T; Kuromatsu R; Yano H; Cao Y; Koga H; Torimura T
Article: GUT. 2023;72(4):710-721
Novel TCF21^high pericyte subpopulation promotes colorectal cancer metastasis by remodelling perivascular matrix
Li X; Pan J; Liu T; Yin W; Miao Q; Zhao Z; Gao Y; Zheng W; Li H; Deng R; Huang D; Qiu S; Zhang Y; Qi Q; Deng L; Huang M; Tang PM-K; Cao Y; Chen M; Ye W; Zhang D
Article: CELLS. 2023;12(3):508
Novel Zebrafish Patient-Derived Tumor Xenograft Methodology for Evaluating Efficacy of Immune-Stimulating BCG Therapy in Urinary Bladder Cancer
Kowald S; Huge Y; Tandiono D; Ali Z; Vazquez-Rodriguez G; Erkstam A; Fahlgren A; Sherif A; Cao Y; Jensen LD
Article: NATURE METABOLISM. 2022;4(12):1674-1683
COVID-19 instigates adipose browning and atrophy through VEGF in small mammals
Jing X; Wu J; Dong C; Gao J; Seki T; Kim C; Urgard E; Hosaka K; Yang Y; Long S; Huang P; Zheng J; Szekely L; Zhang Y; Tao W; Coquet J; Ge M; Chen Y; Adner M; Cao Y
Article: BIOACTIVE MATERIALS. 2022;18:446-458
A facile and general method for synthesis of antibiotic-free protein-based hydrogel: Wound dressing for the eradication of drug-resistant bacteria and biofilms
Ouyang J; Bu Q; Tao N; Chen M; Liu H; Zhou J; Liu J; Deng B; Kong N; Zhang X; Chen T; Cao Y; Tao W
Article: SCIENCE TRANSLATIONAL MEDICINE. 2022;14(673):eabn9061
Dietary ketone body-escalated histone acetylation in megakaryocytes alleviates chemotherapy-induced thrombocytopenia
Xie S; Jiang C; Wu M; Ye Y; Wu B; Sun X; Lv X; Chen R; Yu W; Sun Q; Wu Y; Que R; Li H; Yang L; Liu W; Zuo J; Jensen LD; Huang G; Cao Y; Yang Y
Article: ANGIOGENESIS. 2022;25(4):517-533
PDGFD switches on stem cell endothelial commitment
Lu W; Xu P; Deng B; Zhang J; Zhan Y; Lin X; Xu X; Xia Z; Yang X; Zeng X; Huang L; Xie B; Wang C; Wang S; Kuang H; Han X; Mora A; Cao Y; Jiang Q; Li X
Article: SEMINARS IN CANCER BIOLOGY. 2022;86(Pt 3):251-261
The impact of VEGF on cancer metastasis and systemic disease
Yang Y; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(40):e2203307119
Generation of mega brown adipose tissue in adults by controlling brown adipocyte differentiation in vivo
Du Q; Wu J; Fischer C; Seki T; Jing X; Gao J; He X; Hosaka K; Tong L; Yasue A; Miyake M; Sobajima M; Oyadomari S; Sun X; Yang Y; Zhou Q; Ge M; Tao W; Yao S; Cao Y
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10(10):e005308
Tumor MHC class I expression alters cancer-associated myelopoiesis driven by host NK cells
Neo SY; Jing X; Tong L; Tong D; Gao J; Chen Z; De Los Santos MC; Burduli N; Ferreira SDS; Wagner AK; Alici E; Rolny C; Cao Y; Lundqvist A
Article: CELL REPORTS MEDICINE. 2022;3(9):100659
Targeting of c-MET and AXL by cabozantinib is a potential therapeutic strategy for patients with head and neck cell carcinoma
Hagege A; Saada-Bouzid E; Ambrosetti D; Rastoin O; Boyer J; He X; Rousset J; Montemagno C; Doyen J; Pedeutour F; Parola J; Bourget I; Luciano F; Bozec A; Cao Y; Pages G; Dufies M
Article: NATURE. 2022;608(7922):421-428
Brown-fat-mediated tumour suppression by cold-altered global metabolism
Seki T; Yang Y; Sun X; Lim S; Xie S; Guo Z; Xiong W; Kuroda M; Sakaue H; Hosaka K; Jing X; Yoshihara M; Qu L; Li X; Chen Y; Cao Y
Article: NATURE METABOLISM. 2022;4(6):739-758
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome
Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
Article: CELL CHEMICAL BIOLOGY. 2022;29(4):572-585.e8
CETSA interaction proteomics define specific RNA-modification pathways as key components of fluorouracil-based cancer drug cytotoxicity
Liang YY; Bacanu S; Sreekumar L; Ramos AD; Dai L; Michaelis M; Cinatl J; Seki T; Cao Y; Coffill CR; Lane DP; Prabhu N; Nordlund P
Article: MOLECULAR THERAPY NUCLEIC ACIDS. 2022;27:880-893
Heterogeneity of human corneal endothelium implicates lncRNA NEAT1 in Fuchs endothelial corneal dystrophy
Wang Q; Dou S; Zhang B; Jiang H; Qi X; Duan H; Wang X; Dong C; Zhang BN; Xie L; Cao Y; Zhou Q; Shi W
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(7):e2112696119
Intravesical delivery of KDM6A-mRNA via mucoadhesive nanoparticles inhibits the metastasis of bladder cancer
Kong N; Zhang R; Wu G; Sui X; Wang J; Kim NY; Blake S; De D; Xie T; Cao Y; Tao W
Article: CHEMICAL ENGINEERING JOURNAL. 2022;429:132328
Proof of concept for dual anticancer effects by a novel nanomaterial-mediated cancer cell killing and nano-radiosensitization
Duo Y; Quan L; Zhu D; Bin Z; Luo G; Wang F-B; Chen J; Cao Y
Article: SCIENCE ADVANCES. 2022;8(2):eabi8683
Imaging and tracing the pattern of adult ovarian angiogenesis implies a strategy against female reproductive aging
Xu X; Mu L; Li L; Liang J; Zhang S; Jia L; Yang X; Dai Y; Zhang J; Wang Y; Niu S; Xia G; Yang Y; Zhang Y; Cao Y; Zhang H
Article: JOURNAL OF CLINICAL INVESTIGATION. 2022;132(1):e146658
Long-term corneal recovery by simultaneous delivery of hPSC-derived corneal endothelial precursors and nicotinamide
Li Z; Duan H; Jia Y; Zhao C; Li W; Wang X; Gong Y; Dong C; Ma B; Dou S; Bin Z; Li D; Cao Y; Xie L; Zhou Q; Shi W
Article: GUT. 2022;71(1):129-147
Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism
Sun X; He X; Zhang Y; Hosaka K; Andersson P; Wu J; Wu J; Jing X; Du Q; Hui X; Ding B; Guo Z; Hong A; Liu X; Wang Y; Ji Q; Beyaert R; Yang Y; Li Q; Cao Y
Article: GENETICS IN MEDICINE. 2022;24(1):157-169
Novel loss-of-function variant in DENND5A impedes melanosomal cargo transport and predisposes to familial cutaneous melanoma
Yang M; Johnsson P; Brautigam L; Yang XR; Thrane K; Gao J; Tobin NP; Zhou Y; Yu R; Nagy N; Engstrom PG; Tuominen R; Eriksson H; Lundeberg J; Tucker MA; Goldstein AM; Egyhazi-Brage S; Zhao J; Cao Y; Hoiom V
Journal article: ADVANCED SCIENCE. 2021;8(21)
Interleukin‐33 is a Novel Immunosuppressor that Protects Cancer Cells from TIL Killing by a Macrophage‐Mediated Shedding Mechanism (Adv. Sci. 21/2021)
Wu J; Chen Z; Wickström SL; Gao J; He X; Jing X; Wu J; Du Q; Yang M; Chen Y; Zhang D; Yin X; Guo Z; Jensen L; Yang Y; Tao W; Lundqvist A; Kiessling R; Cao Y
Article: ADVANCED SCIENCE. 2021;8(21):e2101936
A Novel Mechanism of Endoplasmic Reticulum Stress- and c-Myc-Degradation-Mediated Therapeutic Benefits of Antineurokinin-1 Receptor Drugs in Colorectal Cancer
Shi Y; Wang X; Meng Y; Ma J; Zhang Q; Shao G; Wang L; Cheng X; Hong X; Wang Y; Yan Z; Cao Y; Kang J; Fu C
Article: ADVANCED SCIENCE. 2021;8(21):e2101029
Interleukin-33 is a Novel Immunosuppressor that Protects Cancer Cells from TIL Killing by a Macrophage-Mediated Shedding Mechanism
Wu J; Chen Z; Wickstrom SL; Gao J; He X; Jing X; Wu J; Du Q; Yang M; Chen Y; Zhang D; Yin X; Guo Z; Jensen L; Yang Y; Tao W; Lundqvist A; Kiessling R; Cao Y
Article: CANCER LETTERS. 2021;520:48-56
miR-125a-5p impairs the metastatic potential in breast cancer via IP₆K1 targeting
Minini M; Senni A; He X; Proietti S; Liguoro D; Catizone A; Giuliani A; Mancini R; Fuso A; Cucina A; Cao Y; Bizzarri M
Article: ADVANCED FUNCTIONAL MATERIALS. 2021;31(42)
Nanopoxia: Targeting Cancer Hypoxia by Antimonene-Based Nanoplatform for Precision Cancer Therapy
Qiu M; Duo Y; Liang W; Yang Y; Zhang B; Xie Z; Yang X; Wang G; Xie N; Nie G; Alhartomy OA; ALGhamdi AA; Wageh S; Cao Y; Zhang H
Journal article: EXPLORATION. 2021;1(2):20210051
The impact of the hypoxia-VEGF-vascular permeability on COVID-19-infected patients
Cao Y
Journal article: EMERGENCY AND CRITICAL CARE MEDICINE. 2021;1(1):2-5
Treatment of acute pulmonary edema by blocking VEGF-induced vascular leakage
Cao Y
Article: OCULAR SURFACE. 2021;21:206-220
Molecular identity of human limbal heterogeneity involved in corneal homeostasis and privilege
Dou S; Wang Q; Qi X; Zhang B; Jiang H; Chen S; Duan H; Lu Y; Dong J; Cao Y; Xie L; Zhou Q; Shi W
Article: NANO TODAY. 2021;38:101197
A novel NIR-responsive CO gas-releasing and hyperthermia-generating nanomedicine provides a curative approach for cancer therapy
Jin Z; Duo Y; Li Y; Qiu M; Jiang M; Liu Q; Zhao P; Yang T; Liang W; Zhang H; Cao Y; He Q
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2021;9(6):e002616
Off-tumor IDO1 target engagements determine the cancer-immune set point and predict the immunotherapeutic efficacy
Xie L; Hu K; Duo Y; Shimokawa T; Kumata K; Zhang Y; Jiang C; Zhang L; Nengaki N; Wakizaka H; Cao Y; Zhang M-R
Article: HELIYON. 2021;7(5):e07134
Pulmonary stromal expansion and intra-alveolar coagulation are primary causes of COVID-19 death
Szekely L; Bozoky B; Bendek M; Ostad M; Lavignasse P; Haag L; Wu J; Jing X; Gupta S; Saccon E; Sonnerberg A; Cao Y; Bjornstedt M; Szakos A
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2021;10(7):e12096
Perivascular cell-derived extracellular vesicles stimulate colorectal cancer revascularization after withdrawal of antiangiogenic drugs
Huang M; Chen M; Qi M; Ye G; Pan J; Shi C; Yang Y; Zhao L; Mo X; Zhang Y; Li Y; Zhong J; Lu W; Li X; Zhang J; Lin J; Luo L; Liu T; Tang PM-K; Hong A; Cao Y; Ye W; Zhang D
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(11):e2023290118
A specific RIP3⁺ subpopulation of microglia promotes retinopathy through a hypoxia-triggered necroptotic mechanism
He C; Liu Y; Huang Z; Yang Z; Zhou T; Liu S; Hao Z; Wang J; Feng Q; Liu Y; Cao Y; Liu X
Article: EMBO REPORTS. 2021;22(3):e51329
Phosphodiesterase 4A confers resistance to PGE2-mediated suppression in CD25⁺/CD54⁺ NK cells
Chen Z; Yang Y; Neo SY; Shi H; Chen Y; Wagner AK; Larsson K; Tong L; Jakobsson P-J; Alici E; Wu J; Cao Y; Wang K; Liu LL; Mao Y; Sarhan D; Lundqvist A
Article: COMMUNICATIONS BIOLOGY. 2021;4(1):166
Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma
Dufies M; Verbiest A; Cooley LS; Ndiaye PD; He X; Nottet N; Souleyreau W; Hagege A; Torrino S; Parola J; Giuliano S; Borchiellini D; Schiappa R; Mograbi B; Zucman-Rossi J; Bensalah K; Ravaud A; Auberger P; Bikfalvi A; Chamorey E; Rioux-Leclercq N; Mazure NM; Beuselinck B; Cao Y; Bernhard JC; Ambrosetti D; Pages G
Article: NATURE COMMUNICATIONS. 2021;12(1):814
Efficacy and tolerability of bevacizumab in patients with severe Covid-19
Pang J; Xu F; Aondio G; Li Y; Fumagalli A; Lu M; Valmadre G; Wei J; Bian Y; Canesi M; Damiani G; Zhang Y; Yu D; Chen J; Ji X; Sui W; Wang B; Wu S; Kovacs A; Revera M; Wang H; Jing X; Zhang Y; Chen Y; Cao Y
Article: NANO TODAY. 2021;36:101023
Nano-immunotherapy: Unique mechanisms of nanomaterials in synergizing cancer immunotherapy
Liu Q; Duo Y; Fu J; Qiu M; Sun Z; Adah D; Kang J; Xie Z; Fan T; Bao S; Zhang H; Liu L-P; Cao Y
Article: THERANOSTICS. 2021;11(19):9571-9586
The Polo-like kinase 1 inhibitor onvansertib represents a relevant treatment for head and neck squamous cell carcinoma resistant to cisplatin and radiotherapy
Hagege A; Ambrosetti D; Boyer J; Bozec A; Doyen J; Chamorey E; He X; Bourget I; Rousset J; Saada E; Rastoin O; Parola J; Luciano F; Cao Y; Pages G; Dufies M
Article: ADVANCED SCIENCE. 2020;7(24):2001191
Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer
Liu Q; Xie Z; Qiu M; Shim I; Yang Y; Xie S; Yang Q; Wang D; Chen S; Fan T; Ding B; Guo Z; Adah D; Yao X; Zhang Y; Wu H; Wu Z; Wei C; Wang H; Kim HS; Zou Q; Yan Q; Cai Z; Kim JS; Liu L-P; Zhang H; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(46):28667-28677
In situ sprayed NIR-responsive, analgesic black phosphorus-based gel for diabetic ulcer treatment
Ouyang J; Ji X; Zhang X; Feng C; Tang Z; Kong N; Xie A; Wang J; Sui X; Deng L; Liu Y; Kim JS; Cao Y; Tao W
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(37):22910-22919
Visualization of human T lymphocyte-mediated eradication of cancer cells in vivo
He X; Yin X; Wu J; Wickstrom SL; Duo Y; Du Q; Qin S; Yao S; Jing X; Hosaka K; Wu J; Jensen LD; Lundqvist A; Salter AI; Brautigam L; Tao W; Chen Y; Kiessling R; Cao Y
Article: CELL REPORTS. 2020;32(5):107990
Macrophage K63-Linked Ubiquitination of YAP Promotes Its Nuclear Localization and Exacerbates Atherosclerosis
Liu M; Yan M; Lv H; Wang B; Lv X; Zhang H; Xiang S; Du J; Liu T; Tian Y; Zhang X; Zhou F; Cheng T; Zhu Y; Jiang H; Cao Y; Ai D
Article: NATURE COMMUNICATIONS. 2020;11(1):3704
Therapeutic paradigm of dual targeting VEGF and PDGF for effectively treating FGF-2 off-target tumors
Hosaka K; Yang Y; Seki T; Du Q; Jing X; He X; Wu J; Zhang Y; Morikawa H; Nakamura M; Scherzer M; Sun X; Xu Y; Cheng T; Li X; Liu X; Li Q; Liu Y; Hong A; Chen Y; Cao Y
Article: CANCERS. 2020;12(7):E1883-1883
Fast, In Vivo Model for Drug-Response Prediction in Patients with B-Cell Precursor Acute Lymphoblastic Leukemia
Gauert A; Olk N; Pimentel-Gutierrez H; Astrahantseff K; Jensen LD; Cao Y; Eggert A; Eckert C; Hagemann AIH
Article: SCIENCE ADVANCES. 2020;6(15):eaay6825
Eradication of tumor growth by delivering novel photothermal selenium-coated tellurium nanoheterojunctions
Chen S; Xing C; Huang D; Zhou C; Ding B; Guo Z; Peng Z; Wang D; Zhu X; Liu S; Cai Z; Wu J; Zhao J; Wu Z; Zhang Y; Wei C; Yan Q; Wang H; Fan D; Liu L; Zhang H; Cao Y
Article: NATURE COMMUNICATIONS. 2020;11(1):1211
Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation
Ji Q; Zhou L; Sui H; Yang L; Wu X; Song Q; Jia R; Li R; Sun J; Wang Z; Liu N; Feng Y; Sun X; Cai G; Feng Y; Cai J; Cao Y; Cai G; Wang Y; Li Q
Article: DEVELOPMENTAL BIOLOGY. 2020;457(2):206-214
Synchronized tissue-scale vasculogenesis and ubiquitous lateral sprouting underlie the unique architecture of the choriocapillaris
Ali Z; Cui D; Yang Y; Tracey-White D; Vazquez-Rodriguez G; Moosajee M; Ju R; Li X; Cao Y; Jensen LD
Article: AUTOPHAGY. 2020;16(1):106-122
Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma
Jiang J; Zhang L; Chen H; Lei Y; Zhang T; Wang Y; Jin P; Lan J; Zhou L; Huang Z; Li B; Liu Y; Gao W; Xie K; Zhou L; Nice EC; Peng Y; Cao Y; Wei Y; Wang K; Huang C
Article: FRONTIERS IN PHARMACOLOGY. 2020;11:373
Aldehyde Dehydrogenase 2 Protects Against Post-Cardiac Arrest Myocardial Dysfunction Through a Novel Mechanism of Suppressing Mitochondrial Reactive Oxygen Species Production
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Article: SCIENTIFIC REPORTS. 2019;9(1):19384
CETSA-based target engagement of taxanes as biomarkers for efficacy and resistance
Langeback A; Bacanu S; Laursen H; Mout L; Seki T; Erkens-Schulze S; Ramos AD; Berggren A; Cao Y; Hartman J; van Weerden W; Bergh J; Nordlund P; Loof S
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Neurokinin-1 receptor is an effective target for treating leukemia by inducing oxidative stress through mitochondrial calcium overload
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Article: EMBO MOLECULAR MEDICINE. 2019;11(8):e9266
Apelin inhibition prevents resistance and metastasis associated with anti-angiogenic therapy
Uribesalgo I; Hoffmann D; Zhang Y; Kavirayani A; Lazovic J; Berta J; Novatchkova M; Pai T-P; Wimmer RA; Laszlo V; Schramek D; Karim R; Tortola L; Deswal S; Haas L; Zuber J; Szucs M; Kuba K; Dome B; Cao Y; Haubner BJ; Penninger JM
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Intussusceptive Vascular Remodeling Precedes Pathological Neovascularization
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Bladder drug mirabegron exacerbates atherosclerosis through activation of brown fat-mediated lipolysis
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Article: CIRCULATION. 2018;138(23):2698-2712
Decreased Expression of Vascular Endothelial Growth Factor Receptor 1 Contributes to the Pathogenesis of Hereditary Hemorrhagic Telangiectasia Type 2
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Targeting PDGF-mediated recruitment of pericytes blocks vascular mimicry and tumor growth
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Article: JCI INSIGHT. 2018;3(20):e122375
Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis
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VEGF-B is a potent antioxidant
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Article: CELL METABOLISM. 2018;28(1):104-117.e5
Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance
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CD163⁺ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis
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Ablation of endothelial VEGFR1 improves metabolic dysfunction by inducing adipose tissue browning
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Novel concept of the smart NIR-light-controlled drug release of black phosphorus nanostructure for cancer therapy
Qiu M; Wang D; Liang W; Liu L; Zhang Y; Chen X; Sang DK; Xing C; Li Z; Dong B; Xing F; Fan D; Bao S; Zhang H; Cao Y
Article: CELL DISCOVERY. 2018;4:3
Dual roles of endothelial FGF-2-FGFR1-PDGF-BB and perivascular FGF-2-FGFR2-PDGFRβ signaling pathways in tumor vascular remodeling
Hosaka K; Yang Y; Nakamura M; Andersson P; Yang X; Zhang Y; Seki T; Scherzer M; Dubey O; Wang X; Cao Y
Article: NATURE COMMUNICATIONS. 2017;8(1):2079
A miR-327-FGF10-FGFR2-mediated autocrine signaling mechanism controls white fat browning
Fischer C; Seki T; Lim S; Nakamura M; Andersson P; Yang Y; Honek J; Wang Y; Gao Y; Chen F; Samani NJ; Zhang J; Miyake M; Oyadomari S; Yasue A; Li X; Zhang Y; Liu Y; Cao Y
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Off-tumor targets compromise antiangiogenic drug sensitivity by inducing kidney erythropoietin production
Nakamura M; Zhang Y; Yang Y; Sonmez C; Zheng W; Huang G; Seki T; Iwamoto H; Ding B; Yin L; Foukakis T; Hatschek T; Li X; Hosaka K; Li J; Yu G; Wang X; Liu Y; Cao Y
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Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK
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Article: CLINICAL CANCER RESEARCH. 2017;23(16):4769-4779
A Zebrafish Model Discovers a Novel Mechanism of Stromal Fibroblast-Mediated Cancer Metastasis
Liu C; Zhang Y; Lim S; Hosaka K; Yang Y; Pavlova T; Alkasalias T; Hartman J; Jensen L; Xing X; Wang X; Lu Y; Nie G; Cao Y
Article: CELL DEATH AND DIFFERENTIATION. 2017;24(8):1431-1442
MicroRNA-26a and-26b inhibit lens fibrosis and cataract by negatively regulating Jagged-1/Notch signaling pathway
Chen X; Xiao W; Chen W; Liu X; Wu M; Bo Q; Luo Y; Ye S; Cao Y; Liu Y
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Maintenance of antiangiogenic and antitumor effects by orally active low-dose capecitabine for long-term cancer therapy
Zhang Y; Sun M; Huang G; Yin L; Lai Q; Yang Y; Xing X; Yu G; Sun Y; Wang X; Nie G; Liu Y; Cao Y
Article: JCI INSIGHT. 2017;2(4):e89044
Switching harmful visceral fat to beneficial energy combustion improves metabolic dysfunctions
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Article: CANCER RESEARCH. 2016;76(19):5634-5646
Estrogen Receptor a Promotes Breast Cancer by Reprogramming Choline Metabolism
Jia M; Andreassen T; Jensen L; Bathen TF; Sinha I; Gao H; Zhao C; Haldosen L-A; Cao Y; Girnita L; Moestue SA; Dahlman-Wright K
Article: ONCOGENE. 2016;35(39):5155-5169
Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE
Carmona G; Perera U; Gillett C; Naba A; Law A-L; Sharma VP; Wang J; Wyckoff J; Balsamo M; Mosis F; De Piano M; Monypenny J; Woodman N; McConnell RE; Mouneimne G; Van Hemelrijck M; Cao Y; Condeelis J; Hynes RO; Gertler FB; Krause M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(38):E5618-E5627
Pericyte-fibroblast transition promotes tumor growth and metastasis
Hosaka K; Yang Y; Seki T; Fischer C; Dubey O; Fredlund E; Hartman J; Religa P; Morikawa H; Ishii Y; Sasahara M; Larsson O; Cossu G; Cao R; Lim S; Cao Y
Article: NATURE COMMUNICATIONS. 2016;7:12680
Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism
Yang Y; Zhang Y; Iwamoto H; Hosaka K; Seki T; Andersson P; Lim S; Fischer C; Nakamura M; Abe M; Cao R; Skov PV; Chen F; Chen X; Lu Y; Nie G; Cao Y
Article: NATURE COMMUNICATIONS. 2016;7:12152
Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat
Seki T; Hosaka K; Lim S; Fischer C; Honek J; Yang Y; Andersson P; Nakamura M; Naslund E; Yla-Herttuala S; Sun M; Iwamoto H; Li X; Liu Y; Samani NJ; Cao Y
Article: ONCOTARGET. 2016;7(25):38282-38291
Co-option of pre-existing vascular beds in adipose tissue controls tumor growth rates and angiogenesis
Lim S; Hosaka K; Nakamura M; Cao Y
Article: NATURE COMMUNICATIONS. 2016;7:11385
The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages
Yang Y; Andersson P; Hosaka K; Zhang Y; Cao R; Iwamoto H; Yang X; Nakamura M; Wang J; Zhuang R; Morikawa H; Xue Y; Braun H; Beyaert R; Samani N; Nakae S; Hams E; Dissing S; Fallon PG; Langer R; Cao Y
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Endocrine vasculatures are preferable targets of an antitumor ineffective low dose of anti-VEGF therapy
Zhang Y; Yang Y; Hosaka K; Huang G; Zang J; Chen F; Zhang Y; Samani NJ; Cao Y
Article: NATURE COMMUNICATIONS. 2016;7:10824
MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis
Wong HLX; Jin G; Cao R; Zhang S; Cao Y; Zhou Z
Article: SCIENTIFIC REPORTS. 2016;6:19973
Resveratrol analogue 4,4′-dihydroxy-trans-stilbene potently inhibits cancer invasion and metastasis
Savio M; Ferraro D; Maccario C; Vaccarone R; Jensen LD; Corana F; Mannucci B; Bianchi L; Cao Y; Stivala LA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(44):E5944-E5953
VEGF-B-Neuropilin-1 signaling is spatiotemporally indispensable for vascular and neuronal development in zebrafish
Jensen LD; Nakamura M; Brautigam L; Li X; Liu Y; Samani NJ; Cao Y
Article: ELIFE. 2015;4:e08422
Environmental changes in oxygen tension reveal ROS-dependent neurogenesis and regeneration in the adult newt brain
Hameed LS; Berg DA; Belnoue L; Jensen LD; Cao Y; Simon A
Article: ONCOGENE. 2015;34(37):4867-4878
MicroRNA-206 functions as a pleiotropic modulator of cell proliferation, invasion and lymphangiogenesis in pancreatic adenocarcinoma by targeting ANXA2 and KRAS genes
Keklikoglou I; Hosaka K; Bender C; Bott A; Koerner C; Mitra D; Will R; Woerner A; Muenstermann E; Wilhelm H; Cao Y; Wiemann S
Article: ONCOGENE. 2015;34(36):4713-4722
Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis
Singleton DC; Rouhi P; Zois CE; Haider S; Li J-L; Kessler BM; Cao Y; Harris AL
Article: CLINICAL CANCER RESEARCH. 2015;21(16):3794-3805
CCL2 and CCL5 Are Novel Therapeutic Targets for Estrogen-Dependent Breast Cancer
Svensson S; Abrahamsson A; Rodriguez GV; Olsson A-K; Jensen L; Cao Y; Dabrosin C
Article: SCIENTIFIC REPORTS. 2015;5:10351
Invasiveness and metastasis of retinoblastoma in an orthotopic zebrafish tumor model
Chen X; Wang J; Cao Z; Hosaka K; Jensen L; Yang H; Sun Y; Zhuang R; Liu Y; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(22):E2900-E2909
VEGF-B promotes cancer metastasis through a VEGF-A-independent mechanism and serves as a marker of poor prognosis for cancer patients
Yang X; Zhang Y; Hosaka K; Andersson P; Wang J; Tholander F; Cao Z; Morikawa H; Tegner J; Yang Y; Iwamoto H; Lim S; Cao Y
Article: SCIENCE ADVANCES. 2015;1(3):e1400244
PlGF-induced VEGFR1-dependent vascular remodeling determines opposing antitumor effects and drug resistance to Dll4-Notch inhibitors
Iwamoto H; Zhang Y; Seki T; Yang Y; Nakamura M; Wang J; Yang X; Torimura T; Cao Y
Article: CANCER RESEARCH. 2015;75(2):306-315
Novel Mechanism of Macrophage-Mediated Metastasis Revealed in a Zebrafish Model of Tumor Development
Wang J; Cao Z; Zhang X-M; Nakamura M; Sun M; Hartman J; Harris RA; Sun Y; Cao Y
Article: CELL REPORTS. 2014;9(2):569-580
VEGFR2-Mediated Vascular Dilation as a Mechanism of VEGF-Induced Anemia and Bone Marrow Cell Mobilization
Lim S; Zhang Y; Zhang D; Chen F; Hosaka K; Feng N; Seki T; Andersson P; Li J; Zang J; Sun B; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(41):14906-14911
Modulation of age-related insulin sensitivity by VEGF-dependent vascular plasticity in adipose tissues
Honek J; Seki T; Iwamoto H; Fischer C; Li J; Lim S; Samani NJ; Zang J; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(41):14806-14811
Vasoprotective effect of PDGF-CC mediated by HMOX1 rescues retinal degeneration
He C; Zhao C; Kumar A; Lee C; Chen M; Huang L; Wang J; Ren X; Jiang Y; Chen W; Wang B; Gao Z; Zhong Z; Huang Z; Zhang F; Huang B; Ding H; Ju R; Tang Z; Liu Y; Cao Y; Li X; Liu X
Article: ONCOGENESIS. 2014;3(9):e119
Targeting filamin B induces tumor growth and metastasis via enhanced activity of matrix metalloproteinase-9 and secretion of VEGF-A
Bandaru S; Zhou A-X; Rouhi P; Zhang Y; Bergo MO; Cao Y; Akyurek LM
Article: NATURE COMMUNICATIONS. 2014;5:4944
TNFR1 mediates TNF-α-induced tumour lymphangiogenesis and metastasis by modulating VEGF-C-VEGFR3 signalling
Ji H; Cao R; Yang Y; Zhang Y; Iwamoto H; Lim S; Nakamura M; Andersson P; Wang J; Sun Y; Dissing S; He X; Yang X; Cao Y
Article: CANCER RESEARCH. 2014;74(14):3983-3994
Genome-wide Profiling of AP-1-Regulated Transcription Provides Insights into the Invasiveness of Triple-Negative Breast Cancer
Zhao C; Qiao Y; Jonsson P; Wang J; Xu L; Rouhi P; Sinha I; Cao Y; Williams C; Dahlman-Wright K
Article: JOURNAL OF CLINICAL INVESTIGATION. 2014;124(3):1069-1082
Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis
Arjonen A; Kaukonen R; Mattila E; Rouhi P; Hognas G; Sihto H; Miller BW; Morton JP; Bucher E; Taimen P; Virtakoivu R; Cao Y; Sansom OJ; Joensuu H; Ivaska J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(7):2560-2565
Hypoxia-induced and calpain-dependent cleavage of filamin A regulates the hypoxic response
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Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(2):90-97
Angiostatic Effects of NK Cell-Derived IFN-γ Counteracted by Tumour Cell Bcl-x_L Expression
Wallin RPA; Sundquist VS; Brakenhielm E; Cao Y; Ljunggren H-G; Grandien A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(50):20057-20062
Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1
Brautigam L; Jensen LDE; Poschmann G; Nystrom S; Bannenberg S; Dreij K; Lepka K; Prozorovski T; Montano SJ; Aktas O; Uhlen P; Stuehler K; Cao Y; Holmgren A; Berndt C
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(34):13932-13937
Vascular endothelial growth factor-dependent spatiotemporal dual roles of placental growth factor in modulation of angiogenesis and tumor growth
Yang X; Zhang Y; Yang Y; Lim S; Cao Z; Rak J; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(29):12018-12023
Anti-VEGF- and anti-VEGF receptor-induced vascular alteration in mouse healthy tissues
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Article: SCIENCE. 2013;341(6141):84-87
Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
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Article: CELL METABOLISM. 2013;18(1):118-129
Cold Exposure Promotes Atherosclerotic Plaque Growth and Instability via UCP1-Dependent Lipolysis
Dong M; Yang X; Lim S; Cao Z; Honek J; Lu H; Zhang C; Seki T; Hosaka K; Wahlberg E; Yang J; Zhang L; Lanne T; Sun B; Li X; Liu Y; Zhang Y; Cao Y
Journal article: CANCER RESEARCH. 2013;73(8_Supplement):1623
Abstract 1623: PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells.
Xue Y; Lim S; Yang Y; Wang Z; Jensen LDE; Hedlund E; Andersson P; Sasahara M; Larsson O; Galter D; Cao R; Hosaka K; Cao Y
Article: CELL CYCLE. 2013;12(3):405-408
Clock controls angiogenesis
Jensen LD; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(2):654-659
Tumor cell-derived placental growth factor sensitizes antiangiogenic and antitumor effects of anti-VEGF drugs
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Article: NATURE COMMUNICATIONS. 2013;4:2129
Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis
Hosaka K; Yang Y; Seki T; Nakamura M; Andersson P; Rouhi P; Yang X; Jensen L; Lim S; Feng N; Xue Y; Li X; Larsson O; Ohhashi T; Cao Y
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VEGF significantly restores impaired memory behavior in Alzheimer's mice by improvement of vascular survival
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Article: CELL REPORTS. 2012;2(5):1272-1285
Proliferative and Survival Effects of PUMA Promote Angiogenesis
Zhang F; Li Y; Tang Z; Kumar A; Lee C; Zhang L; Zhu C; Klotzsche-von Ameln A; Wang B; Gao Z; Zhang S; Langer HF; Hou X; Jensen L; Ma W; Wong W; Chavakis T; Liu Y; Cao Y; Li X
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(39):15894-15899
Collaborative interplay between FGF-2 and VEGF-C promotes lymphangiogenesis and metastasis
Cao R; Ji H; Feng N; Zhang Y; Yang X; Andersson P; Sun Y; Tritsaris K; Hansen AJ; Dissing S; Cao Y
Article: CELL REPORTS. 2012;2(2):231-241
Opposing Effects of Circadian Clock Genes Bmal1 and Period2 in Regulation of VEGF-Dependent Angiogenesis in Developing Zebrafish
Jensen LD; Cao Z; Nakamura M; Yang Y; Brautigam L; Andersson P; Zhang Y; Wahlberg E; Lanne T; Hosaka K; Cao Y
Article: MOLECULAR CANCER. 2012;11:50
Targeting filamin A reduces K-RAS-induced lung adenocarcinomas and endothelial response to tumor growth in mice
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Article: CELL CYCLE. 2012;11(15):2793-2798
When MT1-MMP meets ADAMs
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MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling and Calvarial Osteogenesis
Chan KM; Wong HLX; Jin G; Liu B; Cao R; Cao Y; Lehti K; Tryggvason K; Zhou Z
Article: NATURE PROTOCOLS. 2012;7(3):606-615
Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice
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Article: NATURE MEDICINE. 2011;18(1):100-110
PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells
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Article: CIRCULATION. 2011;124(9):1059-U170
Arteriogenic Therapy by Intramyocardial Sustained Delivery of a Novel Growth Factor Combination Prevents Chronic Heart Failure
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Article: NATURE PROTOCOLS. 2011;6(6):817-826
Mouse corneal lymphangiogenesis model
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(10):4117-4122
Antiangiogenic agents significantly improve survival in tumor-bearing mice by increasing tolerance to chemotherapy-induced toxicity
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Journal article: VASCULAR CELL. 2011;3(1):1
It's hard to keep all things angiogenic in one JAR!
Kitajewski J; Cao Y; Slevin M
Article: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 2011;55(4-5):557-562
Antiangiogenic cancer therapy: why do mouse and human patients respond in a different way to the same drug?
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Article: NATURE PROTOCOLS. 2010;5(12):1911-1918
Hypoxia-induced metastasis model in embryonic zebrafish
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Article: NATURE PROTOCOLS. 2010;5(12):1903-1910
Hypoxia-induced retinopathy model in adult zebrafish
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Article: PHYSICAL BIOLOGY. 2010;7(4):046007
Collective cell motion in endothelial monolayers
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Article: NATURE REVIEWS CLINICAL ONCOLOGY. 2010;7(10):604-608
Off-tumor target-beneficial site for antiangiogenic cancer therapy?
Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(36):15886-15891
Angiotensin-converting enzyme 2 attenuates atherosclerotic lesions by targeting vascular cells
Zhang C; Zhao YX; Zhang YH; Zhu L; Deng BP; Zhou ZL; Li SY; Lu XT; Song LL; Lei XM; Tang WB; Wang N; Pan CM; Song HD; Liu CX; Dong B; Zhang Y; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(27):12216-12221
PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets
Hou X; Kumar A; Lee C; Wang B; Arjunan P; Dong L; Maminishkis A; Tang Z; Li Y; Zhang F; Zhang S-Z; Wardega P; Chakrabarty S; Liu B; Wu Z; Colosi P; Fariss RN; Lennartsson J; Nussenblatt R; Gutkind JS; Cao Y; Li X
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Cancer-associated retinopathy A new mechanistic insight on vascular remodeling
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Article: NATURE PROTOCOLS. 2010;5(5):912-920
Adipose angiogenesis: quantitative methods to study microvessel growth, regression and remodeling in vivo
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Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2010;207(4):867-880
Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3β phosphorylation
Tang Z; Arjunan P; Lee C; Li Y; Kumar A; Hou X; Wang B; Wardega P; Zhang F; Dong L; Zhang Y; Zhang S-Z; Ding H; Fariss RN; Becker KG; Lennartsson J; Nagai N; Cao Y; Li X
Article: DISCOVERY MEDICINE. 2010;9(46):179-184
Therapeutic Angiogenesis for Ischemic Disorders: What Is Missing for Clinical Benefits?
Cao Y
Article: CELL CYCLE. 2010;9(5):913-917
Pathological angiogenesis facilitates tumor cell dissemination and metastasis
Rouhi P; Lee SLC; Cao Z; Hedlund E-M; Jensen LD; Cao Y
Article: NATURE REVIEWS DRUG DISCOVERY. 2010;9(2):107-115
Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases
Cao Y
Article: SCIENCE TRANSLATIONAL MEDICINE. 2010;2(15):15ps3
Optimizing the Delivery of Cancer Drugs that Block Angiogenesis
Cao Y; Langer R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(2):856-861
VEGFR1-mediated pericyte ablation links VEGF and PlGF to cancer-associated retinopathy
Cao R; Xue Y; Hedlund E-M; Zhong Z; Tritsaris K; Tondelli B; Lucchini F; Zhu Z; Dissing S; Cao Y
Article: JOURNAL OF ANGIOGENESIS RESEARCH. 2009;1:9
Tumor-derived VEGF modulates hematopoiesis.
Xue Y; Chen F; Zhang D; Lim S; Cao Y
Article: PLOS ONE. 2009;4(11):e7867
Selective inhibition of retinal angiogenesis by targeting PI3 kinase.
Alvarez Y; Astudillo O; Jensen L; Reynolds AL; Waghorne N; Brazil DP; Cao Y; O'Connor JJ; Kennedy BN
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(46):19485-19490
Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model
Lee SLC; Rouhi P; Jensen LD; Zhang D; Ji H; Hauptmann G; Ingham P; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(43):18408-18413
Nitric oxide permits hypoxia-induced lymphatic perfusion by controlling arterial-lymphatic conduits in zebrafish and glass catfish
Jensen LDE; Cao R; Hedlund E-M; Soll I; Lundberg JO; Hauptmann G; Steffensen JF; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(41):17505-17510
Malignant cell-derived PlGF promotes normalization and remodeling of the tumor vasculature
Hedlund E-M; Hosaka K; Zhong Z; Cao R; Cao Y
Journal article: JOURNAL OF ANGIOGENESIS RESEARCH. 2009;1:1
Welcome to Journal of Angiogenesis Research.
Slevin M; Cao Y; Kitajewski J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(15):6152-6157
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis
Zhang F; Tang Z; Hou X; Lennartsson J; Li Y; Koch AW; Scotney P; Lee C; Arjunan P; Dong L; Kumar A; Rissanen TT; Wang B; Nagai N; Fons P; Fariss R; Zhang Y; Wawrousek E; Tansey G; Raber J; Fong G-H; Ding H; Greenberg DA; Becker KG; Herbert J-M; Nash A; Yla-Herttuala S; Cao Y; Watts RJ; Li X
Article: CELL METABOLISM. 2009;9(1):99-109
Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation
Xue Y; Petrovic N; Cao R; Larsson O; Lim S; Chen S; Feldmann HM; Liang Z; Zhu Z; Nedergaard J; Cannon B; Cao Y
Article: FRONTIERS IN BIOSCIENCE-LANDMARK. 2009;14(10):3962-3973
Tumor angiogenesis and molecular targets for therapy
Cao Y
Article: FASEB JOURNAL. 2009;23(1):153-163
Differential roles of PDGFR-α and PDGFR-β in angiogenesis and vessel stability
Zhang J; Cao R; Zhang Y; Jia T; Cao Y; Wahlberg E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(47):18513-18518
Anti-VEGF agents confer survival advantages to tumor-bearing mice by improving cancer-associated systemic syndrome
Xue Y; Religa P; Cao R; Hansen AJ; Lucchini F; Jones B; Wu Y; Zhu Z; Pytowski B; Liang Y; Zhong W; Vezzoni P; Rozell B; Cao Y
Article: CIRCULATION RESEARCH. 2008;103(10):1092-1U71
Vascular Endothelial Growth Factor-A and Platelet-Derived Growth Factor-B Combination Gene Therapy Prolongs Angiogenic Effects via Recruitment of Interstitial Mononuclear Cells and Paracrine Effects Rather Than Improved Pericyte Coverage of Angiogenic Vessels
Korpisalo P; Karvinen H; Rissanen TT; Kilpijoki J; Marjomaki V; Baluk P; McDonald DM; Cao Y; Eriksson U; Alitalo K; Yla-Herttuala S
Article: CANCER RESEARCH. 2008;68(18):7293-7303
A novel gene expression profile in lymphatics associated with tumor growth and nodal metastasis
Clasper S; Royston D; Baban D; Cao Y; Ewers S; Butz S; Vestweber D; Jackson DG
Article: PLOS ONE. 2008;3(7):e2748
Hypoxia-Induced Retinal Angiogenesis in Zebrafish as a Model to Study Retinopathy
Cao R; Jensen LDE; Soell I; Hauptmann G; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(29):10167-10172
FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue
Xue Y; Cao R; Nilsson D; Chen S; Westergren R; Hedlund E-M; Martijn C; Rondahl L; Krauli P; Walum E; Enerback S; Cao Y
Article: JOURNAL OF CLINICAL INVESTIGATION. 2008;118(3):913-923
VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats
Li Y; Zhang F; Nagai N; Tang Z; Zhang S; Scotney P; Lennartsson J; Zhu C; Qu Y; Fang C; Hua J; Matsuo O; Fong G-H; Ding H; Cao Y; Becker KG; Nash A; Heldin C-H; Li X
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2008;37(3):507-518
Characterization of neuroprogenitor cells expressing the PDGF β-receptor within the subventricular zone of postnatal mice
Ishii Y; Matsumoto Y; Watanabe R; Elmi M; Fujimori T; Nissen J; Cao Y; Nabeshima Y-I; Sasahara M; Funa K
Article: JOURNAL OF CLINICAL INVESTIGATION. 2007;117(10):2766-2777
Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis
Nissen LJ; Cao R; Hedlund E-M; Wang Z; Zhao X; Wetterskog D; Funa K; Brakenhielm E; Cao Y
Article: BIOMEDICINE & PHARMACOTHERAPY. 2007;61(9):534-539
Tumor-derived lymphangiogenic factors and lymphatic metastasis
Cao Y; Zhong W
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(39):15364-15369
IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs
Tritsaris K; Myren M; Ditlev SB; Hubschmann MV; van der Blom I; Hansen AJ; Olsen UB; Cao R; Zhang J; Jia T; Wahlberg E; Dissing S; Cao Y
Article: EXPERIMENTAL CELL RESEARCH. 2007;313(13):2896-2909
Intra- and extracellular signaling by endothelial neuregulin-1
Iivanainen E; Paatero I; Heikkinen S-M; Junttila TT; Cao R; Klint P; Jaakkola PM; Cao Y; Elenius K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(29):12140-12145
Combinatorial protein therapy of angiogenic and arteriogenic factors remarkably improves collaterogenesis and cardiac function in pigs
Lu H; Xu X; Zhang M; Cao R; Brakenhielm E; Li C; Lin H; Yao G; Sun H; Qi L; Tang M; Dai H; Zhang Y; Su R; Bi Y; Zhang Y; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(10):3919-3924
Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development
Zhou X; Tian F; Sandzen J; Cao R; Flaberg E; Szekely L; Cao Y; Ohlsson C; Bergo MO; Boren J; Akyurek LM
Article: MOLECULAR AND CELLULAR BIOLOGY. 2006;26(12):4628-4641
Cell-type-specific regulation of degradation of hypoxia-inducible factor 1α:: Role of subcellular compartmentalization
Zheng X; Ruas JL; Cao R; Salomons FA; Cao Y; Poellinger L; Pereira T
Article: BLOOD. 2006;107(9):3531-3536
Hepatocyte growth factor is a lymphanoiogenic factor with an indirect mechanism of action
Cao RH; Björndahl MA; Gallego MI; Chen SH; Religa P; Hansen AJ; Cao YH
Article: GASTROENTEROLOGY. 2006;130(4):1301-1310
Gene transfer of kringle 1-5 suppresses tumor development and improves prognosis of mice with hepatocellular carcinoma
Torimura T; Ueno T; Kin M; Taniguchi E; Nakamura T; Inoue K; Sakata R; Hashimoto O; Sakamoto M; Ohira H; Kumashiro R; Sata M; Yano H; Kojiro M; Veitonmaki N; Cao YH
Article: BLOOD. 2005;106(13):4184-4190
Presence of bone marrow-derived circulating progenitor endothelial cells in the newly formed lymphatic vessels
Religa P; Cao RH; Bjorndahl M; Zhou ZJ; Zhu ZP; Cao YH
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(43):15593-15598
Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo.
Björndahl M; Cao R; Nissen LJ; Clasper S; Johnson LA; Xue Y; Zhou Z; Jackson D; Hansen AJ; Cao Y
Article: CANCER RESEARCH. 2005;65(20):9261-9268
Vascular endothelial growth factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasis
Björndahl MA; Cao R; Burton JB; Brakenhielm E; Religa P; Galter D; Wu L; Cao YH
Article: NATURE MEDICINE. 2005;11(7):780-785
Genomic instability in laminopathy-based premature aging
Liu BH; Wang JM; Chan KM; Tjia WM; Deng W; Guan XY; Huang JD; Li KM; Chau PY; Chen DJ; Pei DQ; Pendas AM; Cadiñanos J; López-Otín C; Tse HF; Hutchison C; Chen JJ; Cao YH; Cheah KSE; Tryggvason K; Zhou ZJ
Article: CELL CYCLE. 2005;4(2):228-230
Direct role of PDGF-BB in lymphangiogenesis and lymphatic metastasis.
Cao Y
Article: CANCER CELL. 2004;6(4):333-345
PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis
Cao RH; Björndahl MA; Religa P; Clasper S; Garvin S; Galter D; Meister B; Ikomi F; Tritsaris K; Dissing S; Ohhashi T; Jackson DG; Cao YH
Article: CANCER RESEARCH. 2004;64(14):4699-4702
Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient mice
Zhou ZJ; Wang JM; Cao RH; Morita H; Soininen R; Chan KM; Liu B; Cao YH; Tryggvason K
Article: CIRCULATION RESEARCH. 2004;94(12):1579-1588
Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice
Bråkenhielm E; Cao RH; Gao BH; Angelin B; Cannon B; Parini P; Cao YH
Article: CANCER RESEARCH. 2004;64(12):4059-4063
Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice
Zhou ZJ; Doi M; Wang JM; Cao RH; Liu BH; Chan KM; Kortesmaa J; Sorokin L; Cao YH; Tryggvason K
Article: CIRCULATION RESEARCH. 2004;94(11):1443-1450
Blockage of VEGF-induced angiogenesis by preventing VEGF secretion
Björndahl M; Cao RH; Eriksson A; Cao YH
Article: CANCER RESEARCH. 2004;64(10):3679-3686
Endothelial cell surface ATP synthase-triggered caspase-apoptotic pathway is essential for K1-5-Induced antiangiogenesis
Veitonmäki N; Cao R; Wu LH; Moser TL; Li B; Pizzo SV; Boris ZY; Cao YH
Article: SEMINARS IN CANCER BIOLOGY. 2004;14(2):139-145
Antiangiogenic cancer therapy.
Cao Y
Article: CIRCULATION RESEARCH. 2004;94(5):664-670
Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeability
Cao RH; Eriksson A; Kubo H; Alitalo K; Cao YH; Thyberg J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(8):2476-2481
Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis
Bråkenhielm E; Veitonmäki N; Cao RH; Kihara S; Matsuzawa YJ; Zhivotovsky B; Funahashi T; Cao YH
Article: SEMINARS IN THROMBOSIS AND HEMOSTASIS. 2004;30(1):83-93
Angiostatin.
Cao Y; Xue L
Journal article: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2003;1(5):s175
579 Significant tumor growth inhibition of glioblastoma xenografts by NNC 47-0011 — a low molecular weight tricyclic tyrosine kinase modulator with anti-angiogenic activity
Cao R; Cao Y; Dissing S; Hansen AJ; Kristjansen PEG; Olsen UB
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(10):6033-6038
Deletion of neuropeptide Y (NPY) 2 receptor in mice results in blockage of NPY-induced angiogenesis and delayed wound healing
Ekstrand AJ; Cao RH; Björndahl M; Nyström S; Jönsson-Rylander AC; Hassani H; Hallberg B; Nordlander M; Cao YH
Article: NATURE MEDICINE. 2003;9(5):604-613
Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2
Cao RH; Bråkenhielm E; Pawliuk R; Wariaro D; Post MJ; Wahlberg E; Leboulch P; Cao YH
Article: FASEB JOURNAL. 2003;17(2):764-766
Immortalization of bovine capillary endothelial cells by hTERT alone involves inactivation of endogenous p16^INK4A/pRb
Veitonmäki N; Fuxe J; Hultdin M; Roos G; Pattersson RF; Cao Y
Article: CIRCULATION. 2003;107(11):1532-1538
Small GTP-binding protein Rac is an essential mediator of vascular endothelial growth factor-induced endothelial fenestrations and vascular permeability
Eriksson A; Cao RH; Roy J; Tritsaris K; Wahlestedt C; Dissing S; Thyberg J; Cao YH
Article: ARTHRITIS RESEARCH & THERAPY. 2003;5(1):r32-R39
The angiogenesis inhibitor protease-activated kringles 1-5 reduces the severity of murine collagen-induced arthritis.
Sumariwalla PF; Cao Y; Wu H-L; Feldmann M; Paleolog EM
Article: NEUROSCIENCE. 2003;120(4):951-960
Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury
Widenfalk J; Lipson A; Jubran M; Hofstetter C; Ebendal T; Cao Y; Olson L
Article: FASEB JOURNAL. 2002;16(12):1575-1583
Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-αα and -αβ receptors
Cao RH; Bråkenhielm E; Li XR; Pietras K; Widenfalk J; Östman A; Eriksson U; Cao YH
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(13):8868-8873
Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea.
Kubo H; Cao R; Brakenhielm E; Mäkinen T; Cao Y; Alitalo K
Article: MOLECULAR THERAPY. 2002;5(4):345-351
Continuous intravascular secretion of endostatin in mice from transduced hematopoietic stem cells
Pawliuk R; Bachelot T; Zurkiya O; Eriksson A; Cao YH; Leboulch P
Article: MOLECULAR AND CELLULAR BIOLOGY. 2002;22(4):1194-1202
Deletion of the laminin α4 chain leads to impaired microvessel maturation
Thyboll J; Kortesmaa J; Cao RH; Soininen R; Wang L; Iivanainen A; Sorokin L; Risling M; Cao YH; Tryggvason K
Article: CANCER CELL. 2002;1(1):99-108
Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers
Eriksson A; Cao RH; Pawliuk R; Berg SM; Tsang M; Zhou D; Fleet C; Tritsaris K; Dissing S; Leboulch P; Cao YH
Article: LABORATORY INVESTIGATION. 2001;81(12):1669-1681
Embryonic stem cell-derived embryoid bodies development in collagen gels recapitulates sprouting angiogenesis.
Feraud O; Cao Y; Vittet D
Article: NATURE. 2001;414(6863):550-554
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
Makino Y; Cao RH; Svensson K; Bertilsson GR; Åsman M; Tanaka H; Cao YH; Berkenstam A; Poellinger L
Article: ONCOGENE. 2001;20(34):4685-4695
The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor.
Ambartsumian N; Klingelhöfer J; Grigorian M; Christensen C; Kriajevska M; Tulchinsky E; Georgiev G; Berezin V; Bock E; Rygaard J; Cao R; Cao Y; Lukanidin E
Article: FASEB JOURNAL. 2001;15(10):1798-1800
Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes.
Bråkenhielm E; Cao R; Cao Y
Article: CIRCULATION. 2001;104(3):358-364
Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect
Aase K; von Euler G; Li X; Pontén A; Thorén P; Cao R; Cao Y; Olofsson B; Gebre-Medhin S; Pekny M; Alitalo K; Betsholtz C; Eriksson U
Article: CANCER RESEARCH. 2001;61(14):5441-5446
Effects of angiostatin gene transfer on functional properties and in vivo growth of Kaposi's sarcoma cells.
Indraccolo S; Morini M; Gola E; Carrozzino F; Habeler W; Minghelli S; Santi L; Chieco-Bianchi L; Cao Y; Albini A; Noonan DM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(11):6390-6395
Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF
Cao RH; Brakenhielm E; Wahlestedt C; Thyberg J; Cao YH
Article: MOLECULAR THERAPY. 2001;3(2):186-196
Combination angiostatin and endostatin gene transfer induces synergistic antiangiogenic activity in vitro and antitumor efficacy in leukemia and solid tumors in mice
Scappaticci FA; Smith R; Pathak A; Schloss D; Lum B; Cao YH; Johnson F; Engleman EG; Nolan GP
Article: ANGIOGENESIS. 2001;4(4):263-268
Statin-AE: a novel angiostatin-endostatin fusion protein with enhanced antiangiogenic and antitumor activity.
Scappaticci FA; Contreras A; Smith R; Bonhoure L; Lum B; Cao Y; Engleman EG; Nolan GP
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(38):29383-29390
Human plasmin enzymatic activity is inhibited by chemically modified dextrans.
Ledoux D; Papy-Garcia D; Escartin Q; Sagot MA; Cao Y; Barritault D; Courtois J; Hornebeck W; Caruelle JP
Journal article: GENE THERAPY AND REGULATION. 2000;1(2):123-139
Antiangiogenic gene therapy
Cao Y
Article: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2000;5(5):547-551
Elevated levels of urine angiostatin and plasminogen/plasmin in cancer patients
Cao YH; Veitonmäki N; Keough K; Cheng H; Lee LS; Cao YM; Zurakowski D
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(8):4052-4057
Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I
Zhou ZJ; Apte SS; Soininen R; Cao RH; Baaklini GY; Rauser RW; Wang JM; Cao YH; Tryggvason K
Article: FASEB JOURNAL. 1999;13(15):2195-2202
Interleukin-18 acts as an angiogenesis and tumor suppressor.
Cao R; Farnebo J; Kurimoto M; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(10):5728-5733
Suppression of angiogenesis and tumor growth by the inhibitor K1-5 generated by plasmin-mediated proteolysis
Cao RH; Wu HL; Veitonmäki N; Linden P; Farnebo J; Shi GY; Cao YH
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(19):13338-13344
Systemic gene delivery expands the repertoire of effective antiangiogenic agents
Liu Y; Thor A; Shtivelman E; Cao YH; Tu GH; Heath TD; Debs RJ
Article: AIDS. 1999;13(11):A5-A9
IAS position paper on prevention of HIV1 mother-to-child transmission
Hirsch MS; Wilfert C; Ammann A; Coovadia HM; Cu-Uvin S; Dabis F; Ekpini RAE; Kallings LO; Mofenson L; Tess B; Bryson Y; Cao Y; Chotpitayasunondh T; Nduati R; Solomon S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(24):14389-14394
Vascular endothelial growth factor C induces angiogenesis in vivo
Cao YH; Linden P; Farnebo J; Cao RH; Eriksson A; Kumar V; Qi JH; Claesson-Welsh L; Alitalo K
Article: LABORATORY INVESTIGATION. 1998;78(8):1029-1030
Microbead assay: a novel assay that detects endothelial cell proliferation and inhibition.
Cao Y; Ji RW; Folkman J
Article: CANCER RESEARCH. 1998;58(15):3362-3369
Viral vector-targeted antiangiogenic gene therapy utilizing an angiostatin complementary DNA.
Tanaka T; Cao Y; Folkman J; Fine HA
Article: JOURNAL OF CLINICAL INVESTIGATION. 1998;101(5):1055-1063
Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases.
Cao Y; O'Reilly MS; Marshall B; Flynn E; Ji RW; Folkman J
Article: ONCOGENE. 1998;16(3):359-367
Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C-gamma and migration of endothelial cells expressing Flt 1.
Landgren E; Schiller P; Cao Y; Claesson-Welsh L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(36):22924-22928
Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth
Cao YH; Chen A; An SSA; Ji RWD; Davidson D; Cao YM; Llinas M
Article: EMBO JOURNAL. 1997;16(13):3898-3911
Proteolytic processing regulates receptor specificity and activity of VEGF-C
Joukov V; Sorsa T; Kumar V; Jeltsch M; ClaessonWelsh L; Cao YH; Saksela O; Kalkkinen N; Alitalo K
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1997;235(3):493-498
Placenta growth factor: identification and characterization of a novel isoform generated by RNA alternative splicing.
Cao Y; Ji WR; Qi P; Rosin A; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1997;94(3):861-866
Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways.
Arbiser JL; Moses MA; Fernandez CA; Ghiso N; Cao Y; Klauber N; Frank D; Brownlee M; Flynn E; Parangi S; Byers HR; Folkman J
Article: JOURNAL OF CLINICAL INVESTIGATION. 1996;98(11):2507-2511
In vivo angiogenic activity and hypoxia induction of heterodimers of placenta growth factor/vascular endothelial growth factor.
Cao Y; Linden P; Shima D; Browne F; Folkman J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(46):29461-29467
Kringle domains of human angiostatin. Characterization of the anti-proliferative activity on endothelial cells.
Cao Y; Ji RW; Davidson D; Schaller J; Marti D; Söhndel S; McCance SG; O'Reilly MS; Llinás M; Folkman J
Article: SCIENCE. 1996;273(5274):510-513
Spinal cord repair in adult paraplegic rats: Partial restoration of hind limb function
Cheng H; Cao YH; Olson L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(6):3154-3162
Heterodimers of placenta growth factor/vascular endothelial growth factor. Endothelial activity, tumor cell expression, and high affinity binding to Flk-1/KDR.
Cao Y; Chen H; Zhou L; Chiang MK; Anand-Apte B; Weatherbee JA; Wang Y; Fang F; Flanagan JG; Tsang ML
Article: BRAIN RESEARCH. 1996;707(1):81-87
Distribution of acidic fibroblast growth factor-like immunoreactivity in rat skeletal muscle fibers
Junttila T; Rechardt L; Cao YH; Hokfelt T; PeltoHuikko M
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 1995;182(6):2069-2077
gro-beta, a -C-X-C- chemokine, is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice.
Cao Y; Chen C; Weatherbee JA; Tsang M; Folkman J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(20):9269-9273
The site of action of neuronal acidic fibroblast growth factor is the organ of Corti of the rat cochlea.
Pirvola U; Cao Y; Oellig C; Suoqiang Z; Pettersson RF; Ylikoski J
Journal article: NEUROSCIENCE. 1994;61(4):891-910
TEMPORAL AND SPATIAL INCREASE OF ASTROGLIAL BASIC FIBROBLAST GROWTH-FACTOR SYNTHESIS AFTER 6-HYDROXYDOPAMINE-INDUCED DEGENERATION OF THE NIGROSTRIATAL DOPAMINE NEURONS
CHADI G; CAO Y; PETTERSSON RF; FUXE K
Journal article: BRAIN RESEARCH. 1993;625(1):45-56
PHOTOCHEMICALLY INDUCED FOCAL CEREBRAL-ISCHEMIA IN RAT - TIME-DEPENDENT AND GLOBAL INCREASE IN EXPRESSION OF BASIC FIBROBLAST GROWTH-FACTOR MESSENGER-RNA
LIPPOLDT A; ANDBJER B; ROSEN L; RICHTER E; GANTEN D; CAO Y; PETTERSSON RF; FUXE K
Journal article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1993;5(10):1321-1333
GAP-43, AFGF, CCK AND ALPHA-CGRP AND BETA-CGRP IN RAT SPINAL MOTONEURONS SUBJECTED TO AXOTOMY AND OR DORSAL-ROOT SEVERANCE
PIEHL F; ARVIDSSON U; JOHNSON H; CULLHEIM S; DAGERLIND A; ULFHAKE B; CAO Y; ELDE R; PETTERSSON RF; TERENIUS L; HOKFELT T
Journal article: DEVELOPMENTAL BRAIN RESEARCH. 1993;75(1):65-73
FIBROBLAST GROWTH-FACTORS ENHANCE DOPAMINE FIBER FORMATION FROM NIGRAL GRAFTS
GIACOBINI MMJ; STROMBERG I; ALMSTROM S; CAO YH; OLSON L
Journal article: JOURNAL OF NEUROSCIENCE RESEARCH. 1993;35(4):419-427
PENTYLENETETRAZOL SEIZURES INCREASE PRO-NERVE GROWTH FACTOR-LIKE IMMUNOREACTIVITY IN THE RETICULAR THALAMIC NUCLEUS AND NERVE GROWTH-FACTOR MESSENGER-RNA IN THE DENTATE GYRUS
HUMPEL C; EBENDAL T; CAO Y; OLSON L
Journal article: JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY. 1993;41(4):521-533
BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) PEPTIDE ANTIBODIES - CHARACTERIZATION USING A VACCINIA VIRUS EXPRESSION SYSTEM
WETMORE CJ; CAO YH; PETTERSSON RF; OLSON L
Journal article: GROWTH FACTORS. 1993;8(4):277-290
Release and subcellular localization of acidic fibroblast growth factor expressed to high levels in HeLa cells.
Cao Y; Pettersson RF
Journal article: JOURNAL OF CELL SCIENCE. 1993;104:77-87
CHARACTERIZATION OF THE NUCLEAR TRANSLOCATION OF ACIDIC FIBROBLAST GROWTH-FACTOR
CAO Y; EKSTROM M; PETTERSSON RF
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1991;88(22):10237-10241
EXPRESSION OF ACIDIC AND BASIC FIBROBLAST GROWTH-FACTORS IN THE SUBSTANTIA-NIGRA OF RAT, MONKEY, AND HUMAN
BEAN AJ; ELDE R; CAO YH; OELLIG C; TAMMINGA C; GOLDSTEIN M; PETTERSSON RF; HOKFELT T
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1991;88(21):9843-9847
BRAIN-DERIVED NEUROTROPHIC FACTOR - SUBCELLULAR COMPARTMENTALIZATION AND INTERNEURONAL TRANSFER AS VISUALIZED WITH ANTIPEPTIDE ANTIBODIES
WETMORE C; CAO YH; PETTERSSON RF; OLSON L
Journal article: NEUROREPORT. 1991;2(10):597-600
BASIC FGF IS PRESENT IN DOPAMINERGIC-NEURONS OF THE VENTRAL MIDBRAIN OF THE RAT
CINTRA A; CAO YH; OELLIG C; TINNER B; BORTOLOTTI F; GOLDSTEIN M; PETTERSSON RF; FUXE K
Journal article: NEURON. 1991;7(3):349-364
PROMINENT EXPRESSION OF ACIDIC FIBROBLAST GROWTH-FACTOR IN MOTOR AND SENSORY NEURONS
ELDE R; CAO Y; CINTRA A; BRELJE TC; PELTOHUIKKO M; JUNTTILA T; FUXE K; PETTERSSON RF; HOKFELT T
Journal article: GROWTH FACTORS. 1990;3(1):1-13
Human acidic fibroblast growth factor overexpressed in insect cells is not secreted into the medium.
Cao YH; Pettersson RF
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All other publications

Review: CHINESE MEDICAL JOURNAL. 2024;137(17):2043-2051
Tumor angiogenesis and anti-angiogenic therapy
Guo Z; Jing X; Sun X; Sun S; Yang Y; Cao Y
Editorial comment: CHINESE MEDICAL JOURNAL. 2024;137(6):636-637
Angiogenesis in diseases: A half-century excursion from the initial therapeutic concept to current clinical benefits
Cao Y
Review: NATURE REVIEWS DRUG DISCOVERY. 2023;22(6):476-495
Targeting angiogenesis in oncology, ophthalmology and beyond
Cao Y; Langer R; Ferrara N
Editorial comment: CHINESE MEDICAL JOURNAL. 2022;135(22):2647-2652
Blood vessels in fat tissues and vasculature-derived signals in controlling lipid metabolism and metabolic disease
Cao Y
Preprint: RESEARCH SQUARE. 2022
New splice variants of VEGF as relevant targets for the treatment of renal cell carcinoma
Montemagno C; Durivault J; Gastaldi C; Dufies M; Vial V; He X; Ambrosetti D; Kamenskaya A; Négrier S; Bernhard JC; Borchiellini D; Cao Y; Pagès G
Review: NATURE MEDICINE. 2022;28(11):2273-2287
The landscape of mRNA nanomedicine
Huang X; Kong N; Zhang X; Cao Y; Langer R; Tao W
Corrigendum: NATURE METABOLISM. 2022;4(10):1421
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome (June, 10.1038/s42255-022-00593-x, 2022)
Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
Preprint: RESEARCH SQUARE. 2022
New splice variants of VEGF as relevant targets for the treatment of Renal Cell Carcinoma
Montemagno C; Durivault J; Gastaldi C; Dufies M; Vial V; He X; Ambrosetti D; Négrier S; Bernhard J-C; Borchiellini D; Cao Y; Pagès G
Review: NATURE REVIEWS CARDIOLOGY. 2022;19(4):228-249
Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis
Chen W; Schilperoort M; Cao Y; Shi J; Tabas I; Tao W
Editorial comment: JOURNAL OF CLINICAL INVESTIGATION. 2021;131(20):e153448
Lymphatics in the broken heart
Brakenhielm E; Chen Y; Cao Y
Preprint: BIORXIV. 2020
Pulmonary stromal expansion and intra-alveolar coagulation are primary causes of Covid-19 death
Szekely L; Bozoky B; Bendek M; Ostad M; Lavignasse P; Haag L; Wu J; Jing X; Gupta S; Saccon E; Sönnerborg A; Cao Y; Björnstedt M; Szakos A
Preprint: MEDRXIV. 2020
A novel mechanism of HIF2-dependent PLK1-mediated metastasis and drug resistance of clear cell Renal Cell Carcinoma
Dufies M; Verbiest A; Cooley LS; Ndiaye PD; Viotti J; He X; Nottet N; Souleyreau W; Hagege A; Torrino S; Parola J; Giuliano S; Borchiellini D; Schiappa R; Mograbi B; Zucman-Rossi J; Bensalah K; Ravaud A; Auberger P; Bikfalvi A; Chamorey E; Rioux-Leclercq N; Mazure NM; Beuselinck B; Cao Y; Bernhard JC; Ambrosetti D; Pagès G
Review: NATURE REVIEWS MATERIALS. 2020;5(11):847-860
A materials-science perspective on tackling COVID-19
Tang Z; Kong N; Zhang X; Liu Y; Hu P; Mou S; Liljestrom P; Shi J; Tan W; Kim JS; Cao Y; Langer R; Leong KW; Farokhzad OC; Tao W
Editorial comment: JOURNAL OF EXPERIMENTAL MEDICINE. 2019;216(8):1730-1732
Endothelial life discontinues without Erk
Cao Y
Review: JOURNAL OF CLINICAL INVESTIGATION. 2019;129(8):3006-3017
Adipocyte and lipid metabolism in cancer drug resistance
Cao Y
Conference publication: ANGIOGENESIS. 2019;22(4):600
Decreased expression of VEGFR1 contributes to the pathogenesis of hereditary hemorrhagic telangiectasia type 2
Thalgott J; Dos-Santos-Luis D; Hosman A; Martin S; Lamande N; Bracquart D; Srun S; Galaris G; de Boer H; Tual-Chalot S; Kroon S; Arthur H; Cao Y; Snijder R; Disch F; Mager J; Rabelink T; Mummery C; Raymond K; Lebrin F
Editorial comment: CELL METABOLISM. 2018;27(6):1163-1165
Obesity Protects Cancer from Drugs Targeting Blood Vessels
Cao Y
Conference publication: INTERNATIONAL JOURNAL OF UROLOGY. 2018;25:308
Off tumor targets compromise antiangiogenic drug sensitivity by inducing kidney erythropoietin production
Nakamura M; Cao Y; Homma Y
Book chapter: ANGIOGENESIS-BASED DERMATOLOGY. 2017;p. 1-26
Angiogenesis: General Concepts
Jensen L; Cao Y
Conference publication: CANCER RESEARCH. 2016;76:3933
CETSA as a diagnostic tool to guide personalized breast cancer therapy
Oeberg A; Laursen H; Packham S; Molina DM; Seki T; Cao Y; Hartman J; Bergh J; Nordlund P; Loeoef S
Review: CHINESE JOURNAL OF CANCER. 2016;35:21-9
Future options of anti-angiogenic cancer therapy
Cao Y
Review: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. 2015;30(5):689-721
Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium
Pettersen EO; Ebbesen P; Gieling RG; Williams KJ; Dubois L; Lambin P; Ward C; Meehan J; Kunkler IH; Langdon SP; Ree AH; Flatmark K; Lyng H; Calzada MJ; del Peso L; Landazuri MO; Goerlach A; Flamm H; Kieninger J; Urban G; Weltin A; Singleton DC; Haider S; Buffa FM; Harris AL; Scozzafava A; Supuran CT; Moser I; Jobst G; Busk M; Toustrup K; Overgaard J; Alsner J; Pouyssegur J; Chiche J; Mazure N; Marchiq I; Parks S; Ahmed A; Ashcroft M; Pastorekova S; Cao Y; Rouschop KM; Wouters BG; Koritzinsky M; Mujcic H; Cojocari D
Editorial comment: ONCOIMMUNOLOGY. 2015;4(3):e989777
Collaborative effects between the TNFα-TNFR1-macrophage axis and the VEGF-C-VEGFR3 signaling in lymphangiogenesis and metastasis
Cao R; Ji H; Yang Y; Cao Y
Book chapter: HANDBOOK OF VASCULAR BIOLOGY TECHNIQUES. 2015;p. 221-229
Adipose Angiogenesis
Fischer C; Lim S; Honek J; Cao Y
Book chapter: HANDBOOK OF VASCULAR BIOLOGY TECHNIQUES. 2015;p. 195-207
Methods for Studying Developmental Angiogenesis in Zebrafish
Ali Z; Wang J; Cao Y; Jensen LD
Review: NATURE REVIEWS ENDOCRINOLOGY. 2014;10(9):530-539
VEGF-targeted cancer therapeutics - paradoxical effects in endocrine organs
Cao Y
Review: HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION. 2014;19(1):5-11
Brown adipose tissue, thermogenesis, angiogenesis: pathophysiological aspects.
Honek J; Lim S; Fischer C; Iwamoto H; Seki T; Cao Y
Review: CHEMICAL IMMUNOLOGY AND ALLERGY. 2014;99:170-179
Angiogenesis as a therapeutic target for obesity and metabolic diseases.
Cao Y
Review: CELL METABOLISM. 2013;18(4):478-489
Angiogenesis and Vascular Functions in Modulation of Obesity, Adipose Metabolism, and Insulin Sensitivity
Cao Y
Review: TRENDS IN MOLECULAR MEDICINE. 2013;19(8):460-473
Multifarious functions of PDGFs and PDGFRs in tumor growth and metastasis
Cao Y
Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2013;24(4):190-199
Erythropoietin in cancer: a dilemma in risk therapy
Cao Y
Conference publication: CANCER RESEARCH. 2013;73:B90
Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model
Rouhl P; Lee SL; Jensen LD; Zhang D; Ji H; Hauptmann G; Ingham P; Cao Y
Book chapter: ANGIOGENESIS IN ADIPOSE TISSUE. 2013;p. 187-228
Leptin, Adiponectin, and Other Adipokines in Regulation of Adipose Tissue Angiogenesis
Brakenhielm E; Cao Y
Book chapter: THE TEXTBOOK OF ANGIOGENESIS AND LYMPHANGIOGENESIS: METHODS AND APPLICATIONS. 2012;p. 85-99
Quantitative Methods to Study Adipose Angiogenesis
Lim S; Honek J; Cao Z; Seki T; Xue Y; Cao Y
Book chapter: MOLECULAR AND TRANSLATIONAL VASCULAR MEDICINE: MOLECULAR AND TRANSLATIONAL MEDICINE. 2012;p. 207-226
Therapeutic Angiogenesis for Critical Limb Ischemia: Complex Mechanisms and Future Challenges
Cao Y
Review: SCIENCE TRANSLATIONAL MEDICINE. 2011;3(114):114rv3
Forty-Year Journey of Angiogenesis Translational Research
Cao Y; Arbiser J; D'Amato RJ; D'Amore PA; Ingber DE; Kerbel R; Klagsbrun M; Lim S; Moses MA; Zetter B; Dvorak H; Langer R
Review: BIRTH DEFECTS RESEARCH PART C - EMBRYO TODAY: REVIEWS. 2011;93(2):182-193
Zebrafish Models to Study Hypoxia-Induced Pathological Angiogenesis in Malignant and Nonmalignant Diseases
Jensen LD; Rouhi P; Cao Z; Lanne T; Wahlberg E; Cao Y
Conference publication: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2010;8(7):153
The selective alpha5beta1 integrin antagonist, CLT-28643, inhibits tumors angiogenesis and growth
Caldirola P; Backman U; Cao Y
Review: EXPERIMENTAL CELL RESEARCH. 2010;316(8):1304-1308
Angiogenesis: What can it offer for future medicine?
Cao Y
Meeting abstract: GUT. 2010;59:A112
COLORECTAL CANCER LYMPHATICS DISPLAY AN ALTERED PHENOTYPE ASSOCIATED WITH LYMPH NODE METASTASIS
Royston DJ; Clasper S; Baban D; Cao Y; Jackson DG
Editorial comment: BLOOD. 2010;115(12):2336-2337
Wake-up call for endothelial cells
Cao Y
Book chapter: THERAPEUTIC ANGIOGENESIS FOR VASCULAR DISEASES. 2010;p. 95-113
Cancer Therapy by Targeting Vascular Endothelial Cell Growth Factor- and Non-Vascular Endothelial Cell Growth Factor-Mediated Angiogenesis
Cao Y
Review: CURRENT MOLECULAR MEDICINE. 2009;9(8):982-991
In Vivo Angiogenesis and Lymphangiogenesis Models
Jensen LD; Cao R; Cao Y
Review: CURRENT MOLECULAR MEDICINE. 2009;9(8):967-972
Monotherapy Versus Combination Therapy of Angiogenic and Arteriogenic Factors for the Treatment of Ischemic Disorders
Cao Y
Editorial comment: CURRENT MOLECULAR MEDICINE. 2009;9(8):928
Hot topic: Angiogenesis and Lymphangiogenesis in Common Diseases
Cao Y
Editorial comment: SEMINARS IN CANCER BIOLOGY. 2009;19(5):277-278
Angiogenesis in malignancy
Cao Y
Review: SEMINARS IN CANCER BIOLOGY. 2009;19(5):338-343
Improvement of antiangiogenic cancer therapy by understanding the mechanisms of angiogenic factor interplay and drug resistance
Cao Y; Zhong W; Sun Y
Review: SCIENCE SIGNALING. 2009;2(59):re1
Positive and Negative Modulation of Angiogenesis by VEGFR1 Ligands
Cao Y
Other: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(36):13203-13205
A review of Judah Folkman's remarkable achievements in biomedicine
Cao Y; Langer R
Review: JOURNAL OF MOLECULAR MEDICINE-JMM. 2008;86(7):785-789
R Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathways
Cao Y; Cao R; Hedlund E-M
Review: CLINICAL LIPIDOLOGY. 2008;3(2):153-162
Therapeutic potential of antiangiogenic agents for prevention and treatment of obesity
Cao Y; Cao R; Xue Y
Review: LYMPHATIC RESEARCH AND BIOLOGY. 2008;6(3-4):145-148
Why and how do tumors stimulate lymphangiogenesis?
Cao Y
Book chapter: METHODS IN MOLECULAR BIOLOGY. 2008;p. 65-81
Angiogenesis in adipose tissue.
Brakenhielm E; Cao Y
Review: MECHANISMS AND THERAPY OF LIVER CANCER. 2008;100:113-131
Molecular mechanisms and therapeutic development of angiogenesis inhibitors
Cao Y
Review: JOURNAL OF CLINICAL INVESTIGATION. 2007;117(9):2362-2368
Angiogenesis modulates adipogenesis and obesity
Cao Y
Conference publication: TISSUE ENGINEERING. 2007;13(7):1695
Factors influencing angiogenic processes in the VascuPlug unit: Analysis of neovascularisation
Hiebl B; Cao Y; Knedlitschek G
Review: MECHANISMS AND THERAPY OF LIVER CANCER. 2007;97:203-224
Therapeutic targets of multiple angiogenic factors for the treatment of cancer and metastasis
Cao Y; Liu Q
Review: BRITISH JOURNAL OF CANCER. 2006;95(12):1611-1625
First international consensus on the methodology of lymphangiogenesis quantification in solid human tumours
Van der Auwera I; Cao Y; Tille JC; Pepper MS; Jackson DG; Fox SB; Harris AL; Dirix LY; Vermeulen PB
Editorial comment: BLOOD. 2006;108(8):2506-2507
VEGF calls its receptors from the recycling compartment
Cao Y
Corrigendum: CANCER CELL. 2006;9(3):239
PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis (vol 6, pg 333, 2004)
Cao RH; Björndahl MA; Religa P; Clasper S; Garvin S; Gaiter D; Meister B; Ikomi F; Tritsoris K; Dissing S; Ohhashi T; Jackson DG; Cao YH
Book chapter: CELL BIOLOGY. 2006;p. 373-378
Chapter 46 Angiogenesis Assays
Cao Y
Book chapter: RESVERATROL IN HEALTH AND DISEASE. 2005;p. 149-165
Resveratrol as an Angiogenesis Inhibitor
Bråkenhielm E; Cao R; Cao Y
Book chapter: RESVERATROL IN HEALTH AND DISEASE: OXIDATIVE STRESS AND DISEASE. 2005;p. 149-165
Resveratrol as an Angiogenesis Inhibitor
Cao R; Cao Y; Brakenhielm E
Published conference paper: BIOMEDICINE & PHARMACOTHERAPY. 2005;59:S340-S343
Tumor angiogenesis and therapy
Cao Y
Review: NATURE REVIEWS CANCER. 2005;5(9):735-743
Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis.
Cao Y
Review: CARDIOVASCULAR RESEARCH. 2005;65(3):639-648
Update on therapeutic neovascularization.
Cao Y; Hong A; Schulten H; Post MJ
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2005;124(4):A4
IL-20 is an angiogenic factor in psoriasis
Hansen A; Cao R; Cao Y; Clausen JT; Dissing S; Hasselager E; Myren M; Norby PL; Olsen UB; Tritsaris K
Book chapter: THE NPY FAMILY OF PEPTIDES IN IMMUNE DISORDERS, INFLAMMATION, ANGIOGENESIS AND CANCER: PROGRESS IN INFLAMMATION RESEARCH. 2005;p. 167-174
NPY-induced angiogenesis in retinopathy and wound healing
Björndahl M; Cao R; Xue L; Cao Y
Corrigendum: CIRCULATION RESEARCH. 2004;95(10):e83-e84
Blockage of VEGF-induced angiogenesis by preventing VEG secretion (vol 94, pg 1443, 2004)
Björndahl
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2003;532:109-120
Angiogenesis inhibitors and their therapeutic potentials.
Yihai C
Review: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. 2002;2(6):667-681
Kringle structures and antiangiogenesis.
Cao Y; Cao R; Veitonmäki N
Review: JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 2002;13(7):380-390
Antiangiogenic mechanisms of diet-derived polyphenols.
Cao Y; Cao R; Bråkenhielm E
Review: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2001;33(4):357-369
Endogenous angiogenesis inhibitors and their therapeutic implications.
Cao Y
Published conference paper: HAEMATOLOGICA. 1999;84(7):643-650
Therapeutic potentials of angiostatin in the treatment of cancer.
Cao Y
Letter: NATURE. 1999;398(6726):381
Angiogenesis inhibited by drinking tea.
Cao Y; Cao R
Conference publication: BLOOD. 1999;94(10):420B
Antiangiogenic gene therapy of murine B16F10 melanoma and L1210 leukemia tumors with angiostatin and endostatin containing MMuLV retroviral vectors.
Scappaticci FA; Smith R; Schloss D; Cao Y; Engleman EG; Nolan GP; Leung L
Review: PROGRESS IN MOLECULAR AND SUBCELLULAR BIOLOGY. 1998;20:161-176
Endogenous angiogenesis inhibitors: angiostatin, endostatin, and other proteolytic fragments.
Cao Y
Book chapter: TROPHIC REGULATION OF THE BASAL GANGLIA. 1994;p. 267-284
18 Acidic and Basic Fibroblast Growth Factors are Present in, and Produce Effects upon, Mesencephalic Dopamine Neurons
BEAN AJ; ELDE R; OELLIG C; CAO Y; PETTERSSON RF; HÖKFELT T
Book chapter: TROPHIC REGULATION OF THE BASAL GANGLIA. 1994;p. 151-165
LOCALIZATION OF NEUROTROPHINS AND THEIR RECEPTORS AT THE MESSENGER RNA AND PROTEIN LEVEL
OLSON L; WETMORE C; BEAN AJ; CAO YH; PETTERSSON RF
Book chapter: TROPHIC REGULATION OF THE BASAL GANGLIA. 1994;p. 1-41
FIBROBLAST GROWTH FACTOR-2, GANGLIOSIDE GM1 AND THE TROPHIC REGULATION OF THE BASAL GANGLIA - FOCUS ON THE NIGROSTRIATAL DOPAMINE NEURONS
FUXE K; CHADI G; AGNATI LF; TINNER B; BOSEN L; JANSON AM; MOLLER A; CINTRA A; CAO Y; GOLDSTEIN M; LINDAHL U; DAVID G; OGREN SO; TOFFANO G; BAIRD A; PETTERSSON RF
Conference publication: JOURNAL OF CELLULAR BIOCHEMISTRY. 1993;:280
LOCALIZATION OF OVEREXPRESSED AFGF IN SENSORY AND MOTOR NEURONS IN CULTURES OF RAT DORSAL-ROOT GANGLIA AND VENTRAL ROOTS
OELLIG C; TAYLOR L; LILJESTROM P; CAO YH; PETTERSSON R
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Grants

Implementation of a zebrafish cancer model in diagnosis of human cancer invasion and prediction of drug responses
Swedish Research Council
1 January 2022 - 31 December 2024
Induce vascular networks in large degradable porous scaffolds by influencing the local microenvironment; spatiotemporal control of growth factors and patterning of mechanical signals
Swedish Research Council
1 January 2021 - 31 December 2024
Interdisciplinary framework on the role of adaptive cellular immunity in SARS-CoV-2 protection
Swedish Research Council
1 January 2021 - 31 December 2023
Mechanistic study of the vasculature-modulated tumor microenvironment in tumor growth, metastasis and drug responses
Swedish Research Council
1 January 2020 - 31 December 2024
Mechanistic and translational research on tumor angiogenesis
Swedish Cancer Society
1 January 2018
Mechanistic and translational research on tumor angiogenesis
Swedish Cancer Society
1 January 2017
Angiogenesis in diseases: mechanisms and therapeutic challenges
Swedish Research Council
1 January 2016 - 31 December 2019
Mechanisms and therapeutic challenges in tumor angiogenesis
Swedish Cancer Society
1 January 2016
Modulation of Adipose Angiogenesis: A New Concept of Treatment of Obesity, Diabetes and other Metabolic Disease
Novo Nordisk Foundation
1 January 2015 - 31 December 2019
Mechanisms and therapeutic challenges in tumor angiogenesis
Swedish Cancer Society
1 January 2015
Hitting cancer on target – Novel strategies for optimizing drug target engagement for improved brest cancer therapies
Knut and Alice Wallenberg Foundation
1 January 2014 - 1 January 2019
Mechanisms and therapeutic challenges in tumor angiogenesis
Swedish Cancer Society
1 January 2014
Cold-induced lipolysis and angiogenesis significantly contribute to development of cardiovascular disease
Novo Nordisk Foundation
29 August 2013 - 29 August 2014
Translational research on angiogenesis in diseases
Swedish Research Council
1 January 2012 - 31 December 2016
New mechanisms of angiogenesis modulators in switching between white and brown adipose tissues
European Research Council
1 March 2010 - 28 February 2015
Angiogenesis as a therapeutic target for non-malignant diseases
Swedish Research Council
1 January 2009 - 31 December 2011

Employments

Professor, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2004-

Degrees and Education

Docent, Karolinska Institutet, 1995

About me

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