Yan Li

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Dr. Li är överläkare/docent inom ortopedi, känd för osseointegrationskirurgi och operationer av övre extremiteter.
Dr. Li har en bred forskningsområden som sträcker sig från prekliniska studier av stamceller och biomaterialforskning, evidensbaserad frakturbehandlingar, till innovationer och avancerade behandlingar med osseointegration.

Forskningsbeskrivning

- Effekterna av åldrande och bioaktiva ämnen på mesenkymala stamceller och skelettvävnader.
- Evidensbaserad behandling av ortopediska skador.
- Ortopedisk osseointegration för rekonstruktion av extremiteter.

Undervisning

- Traumaortopedi för läkarstudenter vid Karolinska Institutet.
- Ortopedisk utbildning inom kompletteringsprogrammet för utländska läkare (KUL) vid Karolinska Institutet.
- Trauma i övre extremiteterna för allmän läkare och ST-läkare.
- Osseointegrationskirurgi för internationella ortopedkirurger.

Artiklar

Article: ADVANCED FUNCTIONAL MATERIALS. 2024;34(35):2303622
Tuneable Recombinant Spider Silk Protein Hydrogels for Drug Release and 3D Cell Culture
Arndt T; Chatterjee U; Shilkova O; Francis J; Lundkvist J; Johansson D; Schmuck B; Greco G; Nordberg AE; Li Y; Wahlberg LU; Langton M; Johansson J; Goetherstroem C; Rising A
Article: STEM CELL RESEARCH & THERAPY. 2024;15(1):238
MiR-34a-HK1 signal axis retards bone marrow mesenchymal stem cell senescence via ameliorating glycolytic metabolism
Sun Y; Zhang C; Ma Q; Yu X; Gao X; Zhang H; Shi Y; Li Y; He X
Article: INDIAN JOURNAL OF ORTHOPAEDICS. 2023;57(9):1452-1460
The Impact of Banana-Shaped Fragments on Trochanteric Hip Fractures Treated by PFNA
Mao W; Yang A-L; Chang S-M; Li Y; Li L-L; Ni H-F; Dong Y-H
Article: COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE. 2023;234:107502
Positive medial cortical support versus anatomical reduction for trochanteric hip fractures: Finite element analysis and biomechanical testing
Mao W; Chang S-M; Zhang Y-Q; Li Y; Du S-C; Hu S-J; Yang A; Zhou K-H
Article: MATERIALS TODAY BIO. 2023;19:100592
Recent advances in biomimetic hemostatic materials
Jiao S; Zhang X; Cai H; Wu S; Ou X; Han G; Zhao J; Li Y; Guo W; Liu T; Qu W
Article: INTERNATIONAL WOUND JOURNAL. 2023;20(2):516-528
The action of topical application of Vitamin B₁₂ ointment on radiodermatitis in a porcine model
Zhao Y-C; Wang H-Y; Li Y-F; Yang X-Y; Li Y; Wang T-J
Article: ACTA BIOMATERIALIA. 2022;152:255-272
Soft substrates promote direct chemical reprogramming of fibroblasts into neurons
Xu Z; Li Y; Li P; Sun Y; Lv S; Wang Y; He X; Xu J; Xu Z; Li L; Li Y
Article: BONE. 2022;162:116479
Secular trends in incidence and seasonal variation of distal radius fracture among children: A nationwide study based on the Swedish National Patient Register 2002-2016
Morohoshi A; Qureshi AR; Iseri K; Morohoshi H; Li Y; Lindholm B; Berg HE; Li F-T
Article: FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY. 2022;10:811128
Extramedullary Osseointegration-A Novel Design of Percutaneous Osseointegration Prosthesis for Amputees
Sun Y; Xu J; Lv S; Xu Z; Li L; Li Y; Li Y
Article: ASIA-PACIFIC JOURNAL OF SPORTS MEDICINE, ARTHROSCOPY, REHABILITATION AND TECHNOLOGY. 2022;27:1-8
Timing of postoperative weightbearing in the treatment of traumatic chondral injuries of the knee in athletes- A systematic review of current concepts in clinical practice
Rolf S; Kwan C-K; Stoddart M; Li Y; Fu S-C
Article: BIOMATERIALS. 2021;273:120836
The bone anchored prostheses for amputees-Historical development, current status, and future aspects
Li Y; Fellabder-Tsai L
Article: STEM CELL RESEARCH & THERAPY. 2021;12(1):271
MiR-34a suppression targets Nampt to ameliorate bone marrow mesenchymal stem cell senescence by regulating NAD⁺-Sirt1 pathway
Pi C; Ma C; Wang H; Sun H; Yu X; Gao X; Yang Y; Sun Y; Zhang H; Shi Y; Li Y; Li Y; He X
Article: AGING-US. 2019;11(11):3505-3522
Nicotinamide phosphoribosyltransferase postpones rat bone marrow mesenchymal stem cell senescence by mediating NAD⁺-Sirt1 signaling
Pi C; Yang Y; Sun Y; Wang H; Sun H; Ma M; Lin L; Shi Y; Li Y; Li Y; He X
Article: JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS: GLOBAL RESEARCH & REVIEWS. 2019;3(1):e097
Thumb Amputations Treated With Osseointegrated Percutaneous Prostheses With Up to 25 Years of Follow-up
Li Y; Kulbacka-Ortiz K; Caine-Winterberger K; Brinemark R
Article: ORTHOPEDICS. 2018;41(2):75-80
Percutaneous Osseointegrated Prostheses for Transfemoral Amputations
Li Y; Lindeque B
Article: UNFALLCHIRURG. 2017;120(4):285-292
Osseointegrated prostheses for rehabilitation following amputation The pioneering Swedish model
Li Y; Branemark R
Article: EXPERIMENTAL CELL RESEARCH. 2017;352(1):45-52
Nicotinamide phosphoribosyltransferase (Nampt) may serve as the marker for osteoblast differentiation of bone marrow-derived mesenchymal stem cells.
He X; He J; Shi Y; Pi C; Yang Y; Sun Y; Ma C; Lin L; Zhang L; Li Y; Li Y
Article: PLOS ONE. 2017;12(1):e0170930
Nampt Expression Decreases Age-Related Senescence in Rat Bone Marrow Mesenchymal Stem Cells by Targeting Sirt1.
Ma C; Pi C; Yang Y; Lin L; Shi Y; Li Y; Li Y; He X
Article: PLOS ONE. 2016;11(1):e0145838
Insulin-Producing Cells Differentiated from Human Bone Marrow Mesenchymal Stem Cells In Vitro Ameliorate Streptozotocin-Induced Diabetic Hyperglycemia
Xin Y; Jiang X; Wang Y; Su X; Sun M; Zhang L; Tan Y; Wintergerst KA; Li Y; Li Y
Article: CALCIFIED TISSUE INTERNATIONAL. 2013;93(6):556-564
FGF23 Affects the Lineage Fate Determination of Mesenchymal Stem Cells
Li Y; He X; Olauson H; Larsson TE; Lindgren U
Article: JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH. 2013;8:30
Diclofenac and triamcinolone acetonide impair tenocytic differentiation and promote adipocytic differentiation of mesenchymal stem cells
Fredriksson M; Li Y; Stalman A; Haldosen L-A; Fellander-Tsai L
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2013;434(1):117-123
Nampt expression increases during osteogenic differentiation of multi- and omnipotent progenitors
Li Y; He J; He X; Li Y; Lindgren U
Article: JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH. 2012;7:17
The direct anterior approach: initial experience of a minimally invasive technique for total hip arthroplasty
Hallert O; Li Y; Brismar H; Lindgren U
Article: JOURNAL OF BONE AND MINERAL RESEARCH. 2011;26(11):2656-2664
Nicotinamide Phosphoribosyltransferase (Nampt) Affects the Lineage Fate Determination of Mesenchymal Stem Cells: A Possible Cause for Reduced Osteogenesis and Increased Adipogenesis in Older Individuals
Li Y; He X; Li Y; He J; Anderstam B; Andersson G; Lindgren U
Article: JOURNAL OF BIOMEDICAL SCIENCE. 2011;18(1):59
High efficient isolation and systematic identification of human adipose-derived mesenchymal stem cells
Yang X-F; He X; He J; Zhang L-H; Su X-J; Dong Z-Y; Xu Y-J; Li Y; Li Y-L
Article: ACTA BIOMATERIALIA. 2011;7(2):751-758
Resveratrol-conjugated poly-ε-caprolactone facilitates in vitro mineralization and in vivo bone regeneration
Li Y; Danmark S; Edlund U; Finne-Wistrand A; He X; Norgard M; Blomen E; Hultenby K; Andersson G; Lindgren U
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;401(3):356-362
Resveratrol prevents RANKL-induced osteoclast differentiation of murine osteoclast progenitor RAW 264.7 cells through inhibition of ROS production
He X; Andersson G; Lindgren U; Li Y
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2009;609(1-3):13-18
Resveratrol inhibits proliferation and promotes apoptosis of osteosarcoma cells
Li Y; Backesjo C-M; Haldosen L-A; Lindgren U
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2008;112(1-3):110-116
Species difference exists in the effects of 1α,25(OH)₂d₃ and its analogue 2-methylene-19-nor-(20S)-1,25-dihydroxyvitamin D₃ (2MD) on osteoblastic cells
Li Y; Backesjo C-M; Haldosen L-A; Lindgren U
Article: CYTOKINE. 2008;43(2):165-173
IL-6 receptor expression and IL-6 effects change during osteoblast differentiation
Li Y; Bakesjo C-M; Haldosen L-A; Lindgren U
Article: JOURNAL OF BONE AND MINERAL RESEARCH. 2006;21(7):993-1002
Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells
Bäckesjö CM; Li Y; Lindgren U; Haldosén LA
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Alla övriga publikationer

Review: JOURNAL OF MATERIALS CHEMISTRY B. 2024;12(7):1706-1729
Functional hemostatic hydrogels: design based on procoagulant principles
Zhang B; Wang M; Tian H; Cai H; Wu S; Jiao S; Zhao J; Li Y; Zhou H; Guo W; Qu W
Letter: INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED. 2022;53(12):4165-4168
Growth Differentiation Factor 7 promotes multiple-lineage differentiation in tenogenic cultures of mesenchymal stem cells
Kumlin M; Lindberg K; Haldosen L-A; Fellaender-Tsai L; Li Y
Published conference paper: CELLS TISSUES ORGANS. 2009;189(1-4):93-97
Activation of Sirt1 Decreases Adipocyte Formation during Osteoblast Differentiation of Mesenchymal Stem Cells
Backesjo C-M; Li Y; Lindgren U; Haldosen L-A
Doctoral thesis: 2008
Factors affecting growth, differentiation and apoptosis of osteoblastic and osteosarcoma cells
Li Y

Anställningar

Anknuten till Forskning, Klinisk vetenskap, intervention och teknik, Karolinska Institutet, 2023-2026

Examina och utbildning

Docent, ortopedi, Karolinska Institutet, 2021
Medicine Doktorsexamen, Institutionen för klinisk vetenskap, intervention och teknik, Karolinska Institutet, 2008

Om mig

Forskningsbeskrivning

Undervisning

Artiklar

Alla övriga publikationer

Anställningar

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI