Yan Li

About me
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About me

Dr. Li is associate professor and senior consultant in Orthopedic surgery who is renowned for osseointegration surgery for amputees and upper extremity surgeries.

Dr. Li has a broad research activity ranging from preclinical studies on osteoprogenitors and biomaterial research, evidence-based treatment for orthopedic trauma, to innovations and advanced treatments with osseointegration.

Research

- The effects of aging and bioactive agents on mesenchymal stem cells and skeletal tissues.
- Evidence-based treatment of orthopedic injuries
- Orthopedic Osseointegration for limb reconstruction.

Teaching

- Trauma orthopedics for medical students at Karolinska Institutet.
- Orthopedics education for completing program for foreign doctors at Karolinska Institutet.
- Upper extremity trauma for doctors and residents at Karolinska Institutet.
- Osseointegration Surgery for international orthopedic surgeons

Articles

Article: ADVANCED FUNCTIONAL MATERIALS. 2024;34(35):2303622
Tuneable Recombinant Spider Silk Protein Hydrogels for Drug Release and 3D Cell Culture
Arndt T; Chatterjee U; Shilkova O; Francis J; Lundkvist J; Johansson D; Schmuck B; Greco G; Nordberg AE; Li Y; Wahlberg LU; Langton M; Johansson J; Goetherstroem C; Rising A
Article: STEM CELL RESEARCH & THERAPY. 2024;15(1):238
MiR-34a-HK1 signal axis retards bone marrow mesenchymal stem cell senescence via ameliorating glycolytic metabolism
Sun Y; Zhang C; Ma Q; Yu X; Gao X; Zhang H; Shi Y; Li Y; He X
Article: INDIAN JOURNAL OF ORTHOPAEDICS. 2023;57(9):1452-1460
The Impact of Banana-Shaped Fragments on Trochanteric Hip Fractures Treated by PFNA
Mao W; Yang A-L; Chang S-M; Li Y; Li L-L; Ni H-F; Dong Y-H
Article: COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE. 2023;234:107502
Positive medial cortical support versus anatomical reduction for trochanteric hip fractures: Finite element analysis and biomechanical testing
Mao W; Chang S-M; Zhang Y-Q; Li Y; Du S-C; Hu S-J; Yang A; Zhou K-H
Article: MATERIALS TODAY BIO. 2023;19:100592
Recent advances in biomimetic hemostatic materials
Jiao S; Zhang X; Cai H; Wu S; Ou X; Han G; Zhao J; Li Y; Guo W; Liu T; Qu W
Article: INTERNATIONAL WOUND JOURNAL. 2023;20(2):516-528
The action of topical application of Vitamin B₁₂ ointment on radiodermatitis in a porcine model
Zhao Y-C; Wang H-Y; Li Y-F; Yang X-Y; Li Y; Wang T-J
Article: ACTA BIOMATERIALIA. 2022;152:255-272
Soft substrates promote direct chemical reprogramming of fibroblasts into neurons
Xu Z; Li Y; Li P; Sun Y; Lv S; Wang Y; He X; Xu J; Xu Z; Li L; Li Y
Article: BONE. 2022;162:116479
Secular trends in incidence and seasonal variation of distal radius fracture among children: A nationwide study based on the Swedish National Patient Register 2002-2016
Morohoshi A; Qureshi AR; Iseri K; Morohoshi H; Li Y; Lindholm B; Berg HE; Li F-T
Article: FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY. 2022;10:811128
Extramedullary Osseointegration-A Novel Design of Percutaneous Osseointegration Prosthesis for Amputees
Sun Y; Xu J; Lv S; Xu Z; Li L; Li Y; Li Y
Article: ASIA-PACIFIC JOURNAL OF SPORTS MEDICINE, ARTHROSCOPY, REHABILITATION AND TECHNOLOGY. 2022;27:1-8
Timing of postoperative weightbearing in the treatment of traumatic chondral injuries of the knee in athletes- A systematic review of current concepts in clinical practice
Rolf S; Kwan C-K; Stoddart M; Li Y; Fu S-C
Article: BIOMATERIALS. 2021;273:120836
The bone anchored prostheses for amputees-Historical development, current status, and future aspects
Li Y; Fellabder-Tsai L
Article: STEM CELL RESEARCH & THERAPY. 2021;12(1):271
MiR-34a suppression targets Nampt to ameliorate bone marrow mesenchymal stem cell senescence by regulating NAD⁺-Sirt1 pathway
Pi C; Ma C; Wang H; Sun H; Yu X; Gao X; Yang Y; Sun Y; Zhang H; Shi Y; Li Y; Li Y; He X
Article: AGING-US. 2019;11(11):3505-3522
Nicotinamide phosphoribosyltransferase postpones rat bone marrow mesenchymal stem cell senescence by mediating NAD⁺-Sirt1 signaling
Pi C; Yang Y; Sun Y; Wang H; Sun H; Ma M; Lin L; Shi Y; Li Y; Li Y; He X
Article: JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS: GLOBAL RESEARCH & REVIEWS. 2019;3(1):e097
Thumb Amputations Treated With Osseointegrated Percutaneous Prostheses With Up to 25 Years of Follow-up
Li Y; Kulbacka-Ortiz K; Caine-Winterberger K; Brinemark R
Article: ORTHOPEDICS. 2018;41(2):75-80
Percutaneous Osseointegrated Prostheses for Transfemoral Amputations
Li Y; Lindeque B
Article: UNFALLCHIRURG. 2017;120(4):285-292
Osseointegrated prostheses for rehabilitation following amputation The pioneering Swedish model
Li Y; Branemark R
Article: EXPERIMENTAL CELL RESEARCH. 2017;352(1):45-52
Nicotinamide phosphoribosyltransferase (Nampt) may serve as the marker for osteoblast differentiation of bone marrow-derived mesenchymal stem cells.
He X; He J; Shi Y; Pi C; Yang Y; Sun Y; Ma C; Lin L; Zhang L; Li Y; Li Y
Article: PLOS ONE. 2017;12(1):e0170930
Nampt Expression Decreases Age-Related Senescence in Rat Bone Marrow Mesenchymal Stem Cells by Targeting Sirt1.
Ma C; Pi C; Yang Y; Lin L; Shi Y; Li Y; Li Y; He X
Article: PLOS ONE. 2016;11(1):e0145838
Insulin-Producing Cells Differentiated from Human Bone Marrow Mesenchymal Stem Cells In Vitro Ameliorate Streptozotocin-Induced Diabetic Hyperglycemia
Xin Y; Jiang X; Wang Y; Su X; Sun M; Zhang L; Tan Y; Wintergerst KA; Li Y; Li Y
Article: CALCIFIED TISSUE INTERNATIONAL. 2013;93(6):556-564
FGF23 Affects the Lineage Fate Determination of Mesenchymal Stem Cells
Li Y; He X; Olauson H; Larsson TE; Lindgren U
Article: JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH. 2013;8:30
Diclofenac and triamcinolone acetonide impair tenocytic differentiation and promote adipocytic differentiation of mesenchymal stem cells
Fredriksson M; Li Y; Stalman A; Haldosen L-A; Fellander-Tsai L
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2013;434(1):117-123
Nampt expression increases during osteogenic differentiation of multi- and omnipotent progenitors
Li Y; He J; He X; Li Y; Lindgren U
Article: JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH. 2012;7:17
The direct anterior approach: initial experience of a minimally invasive technique for total hip arthroplasty
Hallert O; Li Y; Brismar H; Lindgren U
Article: JOURNAL OF BONE AND MINERAL RESEARCH. 2011;26(11):2656-2664
Nicotinamide Phosphoribosyltransferase (Nampt) Affects the Lineage Fate Determination of Mesenchymal Stem Cells: A Possible Cause for Reduced Osteogenesis and Increased Adipogenesis in Older Individuals
Li Y; He X; Li Y; He J; Anderstam B; Andersson G; Lindgren U
Article: JOURNAL OF BIOMEDICAL SCIENCE. 2011;18(1):59
High efficient isolation and systematic identification of human adipose-derived mesenchymal stem cells
Yang X-F; He X; He J; Zhang L-H; Su X-J; Dong Z-Y; Xu Y-J; Li Y; Li Y-L
Article: ACTA BIOMATERIALIA. 2011;7(2):751-758
Resveratrol-conjugated poly-ε-caprolactone facilitates in vitro mineralization and in vivo bone regeneration
Li Y; Danmark S; Edlund U; Finne-Wistrand A; He X; Norgard M; Blomen E; Hultenby K; Andersson G; Lindgren U
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;401(3):356-362
Resveratrol prevents RANKL-induced osteoclast differentiation of murine osteoclast progenitor RAW 264.7 cells through inhibition of ROS production
He X; Andersson G; Lindgren U; Li Y
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2009;609(1-3):13-18
Resveratrol inhibits proliferation and promotes apoptosis of osteosarcoma cells
Li Y; Backesjo C-M; Haldosen L-A; Lindgren U
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2008;112(1-3):110-116
Species difference exists in the effects of 1α,25(OH)₂d₃ and its analogue 2-methylene-19-nor-(20S)-1,25-dihydroxyvitamin D₃ (2MD) on osteoblastic cells
Li Y; Backesjo C-M; Haldosen L-A; Lindgren U
Article: CYTOKINE. 2008;43(2):165-173
IL-6 receptor expression and IL-6 effects change during osteoblast differentiation
Li Y; Bakesjo C-M; Haldosen L-A; Lindgren U
Article: JOURNAL OF BONE AND MINERAL RESEARCH. 2006;21(7):993-1002
Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells
Bäckesjö CM; Li Y; Lindgren U; Haldosén LA
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All other publications

Review: JOURNAL OF MATERIALS CHEMISTRY B. 2024;12(7):1706-1729
Functional hemostatic hydrogels: design based on procoagulant principles
Zhang B; Wang M; Tian H; Cai H; Wu S; Jiao S; Zhao J; Li Y; Zhou H; Guo W; Qu W
Letter: INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED. 2022;53(12):4165-4168
Growth Differentiation Factor 7 promotes multiple-lineage differentiation in tenogenic cultures of mesenchymal stem cells
Kumlin M; Lindberg K; Haldosen L-A; Fellaender-Tsai L; Li Y
Published conference paper: CELLS TISSUES ORGANS. 2009;189(1-4):93-97
Activation of Sirt1 Decreases Adipocyte Formation during Osteoblast Differentiation of Mesenchymal Stem Cells
Backesjo C-M; Li Y; Lindgren U; Haldosen L-A
Doctoral thesis: 2008
Factors affecting growth, differentiation and apoptosis of osteoblastic and osteosarcoma cells
Li Y

Employments

Affiliated to Research, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 2023-2026

Degrees and Education

Docent, Karolinska Institutet, 2021
Degree Of Doctor Of Philosophy, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 2008

About me

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