Thomas Helleday

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Thomas Helleday är professor i kemisk biologi. I sin forskning fokuserar han på att försöka utnyttja cancercellers svaghet inom DNA-reparation och ändrad metabolism. Hans forskargrupp använder genetiska verktyg och tar fram prober för att kunna närmare studera identifierade målproteiner. Genom att selektivt inhibera DNA-reparation eller proteiner som är viktiga för tillväxt av cancerceller skräddarsyr forskarna nya behandlingsmetoder mot cancer.

Artiklar

Article: MOLECULAR ONCOLOGY. 2024;18(9):2179-2195
The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation
Marttila P; Bonagas N; Chalkiadaki C; Stigsdotter H; Schelzig K; Shen J; Farhat CM; Hondema A; Albers J; Wiita E; Rasti A; Warpman Berglund U; Slipicevic A; Mortusewicz O; Helleday T
Article: NATURE COMMUNICATIONS. 2024;15(1):3475
High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue
Zhang N; Harbers L; Simonetti M; Diekmann C; Verron Q; Berrino E; Bellomo SE; Longo GMC; Ratz M; Schultz N; Tarish F; Su P; Han B; Wang W; Onorato S; Grassini D; Ballarino R; Giordano S; Yang Q; Sapino A; Frisen J; Alkass K; Druid H; Roukos V; Helleday T; Marchio C; Bienko M; Crosetto N
Article: CELL DEATH & DISEASE. 2024;15(2):150
Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence
Fabbrizi MR; Nickson CM; Hughes JR; Robinson EA; Vaidya K; Rubbi CP; Kacperek A; Bryant HE; Helleday T; Parsons JL
Article: ISCIENCE. 2024;27(2):108907
Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel
Zhang SM; Paulin CBJ; Shu H; Yagu-Capilla M; Michel M; Marttila P; Ortis F; Bwanika HC; Dirks C; Venkatram RP; Wiita E; Jemth A-S; Almlof I; Loseva O; Hormann FM; Koolmeister T; Linde E; Lee S; Llona-Minguez S; Haraldsson M; Axelsson H; Stromberg K; Homan EJ; Scobie M; Lundback T; Helleday T; Rudd SG
Article: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2023;26(29)
Synthesis of Substituted Indazole Acetic Acids by N-N Bond Forming Reactions
Odell LR; Skillinghaug B; Matt C; Wu P; Koolmeister T; Desroses M; Llona-Minguez S; Wallner O; Helleday T; Scobie M
Article: BLOOD. 2023;141(26):3166-3183
Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL
Largeot A; Klapp V; Viry E; Gonder S; Botana IF; Blomme A; Benzarti M; Pierson S; Duculty C; Marttila P; Wierz M; Gargiulo E; Pagano G; An N; El Hachem N; Hernandez DP; Chakraborty S; Ysebaert L; Francois J-H; Clemente SC; Berchem G; Efremov DG; Dittmar G; Szpakowska M; Chevigne A; Nazarov PV; Helleday T; Close P; Meiser J; Stamatopoulos B; Desaubry L; Paggetti J; Moussay E
Article: ONCOGENE. 2023;42(16):1282-1293
NUDT22 promotes cancer growth through pyrimidine salvage
Walter M; Mayr F; Hanna BMF; Cookson V; Mortusewicz O; Helleday T; Herr P
Article: NATURE METABOLISM. 2023;5(4):642-659
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells
Green AC; Marttila P; Kiweler N; Chalkiadaki C; Wiita E; Cookson V; Lesur A; Eiden K; Bernardin F; Vallin KSA; Borhade S; Long M; Ghahe EK; Jimenez-Alonso JJ; Jemth A-S; Loseva O; Mortusewicz O; Meyers M; Viry E; Johansson AI; Hodek O; Homan E; Bonagas N; Ramos L; Sandberg L; Frodin M; Moussay E; Slipicevic A; Letellier E; Paggetti J; Sorensen CS; Helleday T; Henriksson M; Meiser J
Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2023;21(1):169
Short term starvation potentiates the efficacy of chemotherapy in triple negative breast cancer via metabolic reprogramming
Pateras IS; Williams C; Gianniou DD; Margetis AT; Avgeris M; Rousakis P; Legaki A-I; Mirtschink P; Zhang W; Panoutsopoulou K; Delis AD; Pagakis SN; Tang W; Ambs S; Berglund UW; Helleday T; Varvarigou A; Chatzigeorgiou A; Nordstrom A; Tsitsilonis OE; Trougakos IP; Gilthorpe JD; Frisan T
Article: NATURE COMMUNICATIONS. 2023;14(1):643
Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model
Tanner L; Single AB; Bhongir RKV; Heusel M; Mohanty T; Karlsson CAQ; Pan L; Clausson C-M; Bergwik J; Wang K; Andersson CK; Oommen RM; Erjefalt JS; Malmstrom J; Wallner O; Boldogh I; Helleday T; Kalderen C; Egesten A
Article: CHEMMEDCHEM. 2023;18(1):e202200310
Optimization of N-Piperidinyl-Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8-Oxo-Guanine DNA Glycosylase 1
Wallner O; Cazares-Korner A; Scaletti ER; Masuyer G; Bekkhus T; Visnes T; Mamonov K; Ortis F; Lundback T; Volkova M; Koolmeister T; Wiita E; Loseva O; Pandey M; Homan E; Benitez-Buelga C; Davies J; Scobie M; Berglund UW; Kalderen C; Stenmark P; Helleday T; Michel M
Article: F1000RESEARCH. 2023;12:954
Ex-vivo drug screening of surgically resected glioma stem cells to replace murine avatars and provide personalise cancer therapy for glioblastoma patients.
Gagg H; Williams ST; Conroy S; Myers KN; McGarrity-Cottrell C; Jones C; Helleday T; Rantala J; Rominiyi O; Danson SJ; Collis SJ; Wells G
Article: CANCER TREATMENT AND RESEARCH. 2023;186:223-237
Mitotic MTH1 Inhibitors in Treatment of Cancer.
Helleday T
Article: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. 2023;37:3946320231158025
Infiltrating immune cells in prostate cancer tissue after androgen deprivation and radiotherapy
Erlandsson A; Lundholm M; Watz J; Bergh A; Petrova E; Alamdari F; Helleday T; Davidsson S; Andren O; Tarish F
Article: CELLS. 2022;11(24):4121
An Approach for Systems-Level Understanding of Prostate Cancer from High-Throughput Data Integration to Pathway Modeling and Simulation
Mobashir M; Turunen SP; Izhari MA; Ashankyty IM; Helleday T; Lehti K
Article: BIOMOLECULES. 2022;12(12):1777
Overexpressed c-Myc Sensitizes Cells to TH1579, a Mitotic Arrest and Oxidative DNA Damage Inducer
Henriksson S; Calderon-Montano JM; Solvie D; Berglund UW; Helleday T
Article: JOURNAL OF HEPATOLOGY. 2022;77(5):1311-1324
NUDT1 promotes the accumulation and longevity of CD103⁺ T_RM cells in primary biliary cholangitis
Huang B; Lyu Z; Qian Q; Chen Y; Zhang J; Li B; Li Y; Liang J; Liu Q; Li Y; Chen R; Lian M; Xiao X; Miao Q; Wang Q; Fang J; Lian Z; Li Y; Tang R; Helleday T; Gershwin ME; You Z; Ma X
Article: NATURE COMMUNICATIONS. 2022;13(1):5475
Spatio-temporal analysis of prostate tumors in situ suggests pre-existence of treatment-resistant clones
Marklund M; Schultz N; Friedrich S; Berglund E; Tarish F; Tanoglidi A; Liu Y; Bergenstrahle L; Erickson A; Helleday T; Lamb AD; Sonnhammer E; Lundeberg J
Article: CHEMMEDCHEM. 2022;17(18):e202200274
The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform-Selective Inhibitors
Scaletti ER; Gustafsson Westergren R; Andersson Y; Wiita E; Henriksson M; Homan EJ; Jemth A-S; Helleday T; Stenmark P
Article: NATURE. 2022;608(7922):360-367
Spatially resolved clonal copy number alterations in benign and malignant tissue
Erickson A; He M; Berglund E; Marklund M; Mirzazadeh R; Schultz N; Kvastad L; Andersson A; Bergenstrahle L; Bergenstrahle J; Larsson L; Galicia LA; Shamikh A; Basmaci E; De Stahl TD; Rajakumar T; Doultsinos D; Thrane K; Ji AL; Khavari PA; Tarish F; Tanoglidi A; Maaskola J; Colling R; Mirtti T; Hamdy FC; Woodcock DJ; Helleday T; Mills IG; Lamb AD; Lundeberg J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2022;298(8):102169
Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir
Jemth A-S; Scaletti ER; Homan E; Stenmark P; Helleday T; Michel M
Article: SCIENCE. 2022;376(6600):1471-1476
Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.
Michel M; Benítez-Buelga C; Calvo PA; Hanna BMF; Mortusewicz O; Masuyer G; Davies J; Wallner O; Sanjiv K; Albers JJ; Castañeda-Zegarra S; Jemth A-S; Visnes T; Sastre-Perona A; Danda AN; Homan EJ; Marimuthu K; Zhenjun Z; Chi CN; Sarno A; Wiita E; von Nicolai C; Komor AJ; Rajagopal V; Müller S; Hank EC; Varga M; Scaletti ER; Pandey M; Karsten S; Haslene-Hox H; Loevenich S; Marttila P; Rasti A; Mamonov K; Ortis F; Schömberg F; Loseva O; Stewart J; D'Arcy-Evans N; Koolmeister T; Henriksson M; Michel D; de Ory A; Acero L; Calvete O; Scobie M; Hertweck C; Vilotijevic I; Kalderén C; Osorio A; Perona R; Stolz A; Stenmark P; Berglund UW; de Vega M; Helleday T
Article: MOLECULAR CANCER THERAPEUTICS. 2022;21(5):703-714
Inhibition of Oxidized Nucleotide Sanitation By TH1579 and Conventional Chemotherapy Cooperatively Enhance Oxidative DNA Damage and Survival in AML
Centio A; Estruch M; Reckzeh K; Sanjiv K; Vittori C; Engelhard S; Berglund UW; Helleday T; Theilgaard-Monch K
Article: HEPATOLOGY COMMUNICATIONS. 2022;6(5):1016-1031
MutT Homolog 1 Inhibitor Karonudib Attenuates Autoimmune Hepatitis by Inhibiting DNA Repair in Activated T Cells
Chen Y; Hua X; Huang B; Karsten S; You Z; Li B; Li Y; Li Y; Liang J; Zhang J; Wei Y; Chen R; Lyu Z; Xiao X; Lian M; Wei J; Fang J; Miao Q; Wang Q; Berglung UW; Tang R; Helleday T; Ma X
Article: NATURE CANCER. 2022;3(2):156-172
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
Bonagas N; Gustafsson NMS; Henriksson M; Marttila P; Gustafsson R; Wiita E; Borhade S; Green AC; Vallin KSA; Sarno A; Svensson R; Gokturk C; Pham T; Jemth A-S; Loseva O; Cookson V; Kiweler N; Sandberg L; Rasti A; Unterlass JE; Haraldsson M; Andersson Y; Scaletti ER; Bengtsson C; Paulin CBJ; Sanjiv K; Abdurakhmanov E; Pudelko L; Kunz B; Desroses M; Iliev P; Farnegardh K; Kramer A; Garg N; Michel M; Haggblad S; Jarvius M; Kalderen C; Jensen AB; Almlof I; Karsten S; Zhang SM; Haggblad M; Eriksson A; Liu J; Glinghammar B; Nekhotiaeva N; Klingegard F; Koolmeister T; Martens U; Llona-Minguez S; Moulson R; Nordstrom H; Parrow V; Dahllund L; Sjoberg B; Vargas IL; Vo DD; Wannberg J; Knapp S; Krokan HE; Arvidsson PI; Scobie M; Meiser J; Stenmark P; Berglund UW; Homan EJ; Helleday T
Article: FRONTIERS IN ONCOLOGY. 2022;12:888810
OGG1 Inhibition Triggers Synthetic Lethality and Enhances The Effect of PARP Inhibitor Olaparib in BRCA1-Deficient TNBC Cells
Baquero JM; Marchena-Perea E; Mirabet R; Torres-Ruiz R; Blanco-Aparicio C; Rodriguez-Perales S; Helleday T; Benitez-Buelga C; Benitez J; Osorio A
Article: FRONTIERS IN PHARMACOLOGY. 2022;13:999180
Pharmacological OGG1 inhibition decreases murine allergic airway inflammation
Tanner L; Bergwik J; Bhongir RKV; Pan L; Dong C; Wallner O; Kalderen C; Helleday T; Boldogh I; Adner M; Egesten A
Article: CELL DEATH AND DIFFERENTIATION. 2022;29(1):246-261
MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells.
Karsten S; Fiskesund R; Zhang X-M; Marttila P; Sanjiv K; Pham T; Rasti A; Bräutigam L; Almlöf I; Marcusson-Ståhl M; Sandman C; Platzack B; Harris RA; Kalderén C; Cederbrant K; Helleday T; Warpman Berglund U
Article: CELL CHEMICAL BIOLOGY. 2021;28(12):1693-1702.e6
NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir
Zhang SM; Rehling D; Jemth A-S; Throup A; Landazuri N; Almlof I; Gottmann M; Valerie NCK; Borhade SR; Wakchaure P; Page BDG; Desroses M; Homan EJ; Scobie M; Rudd SG; Berglund UW; Soderberg-Naucler C; Stenmark P; Helleday T
Article: CANCER RESEARCH. 2021;81(22):5733-5744
MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia
Sanjiv K; Calderon-Montano JM; Pham TM; Erkers T; Tsuber V; Almlof I; Hoglund A; Heshmati Y; Seashore-Ludlow B; Danda AN; Gad H; Wiita E; Gokturk C; Rasti A; Friedrich S; Centio A; Estruch M; Vatsveen TK; Struyf N; Visnes T; Scobie M; Koolmeister T; Henriksson M; Wallner O; Sandvall T; Lehmann S; Theilgaard-Monch K; Garnett MJ; Ostling P; Walfridsson J; Helleday T; Berglund UW
Article: CELLS. 2021;10(11):3040
Adaptation to Chronic-Cycling Hypoxia Renders Cancer Cells Resistant to MTH1-Inhibitor Treatment Which Can Be Counteracted by Glutathione Depletion
Hansel C; Hlouschek J; Xiang K; Melnikova M; Thomale J; Helleday T; Jendrossek V; Matschke J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(36):e2007898118
Defects in 8-oxo-guanine repair pathway cause high frequency of C > A substitutions in neuroblastoma
van den Boogaard ML; Oka R; Hakkert A; Schild L; Ebus ME; van Gerven MR; Zwijnenburg DA; Molenaar P; Hoyng LL; Dolman MEM; Essing AHW; Koopmans B; Helleday T; Drost J; van Boxtel R; Versteeg R; Koster J; Molenaar JJ
Article: CANCER RESEARCH. 2021;81(15):4079-4093
NEIL3 Prevents Senescence in Hepatocellular Carcinoma by Repairing Oxidative Lesions at Telomeres during Mitosis
Zhao Z; Gad H; Benitez-Buelga C; Sanjiv K; Hua X; Kang H; Feng M; Zhao Z; Berglund UW; Xia Q; Helleday T
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2021;141(8):2037-2048.e4
MTH1 Inhibitors for the Treatment of Psoriasis
Eding CB; Kohler I; Verma D; Sjogren F; Bamberg C; Karsten S; Pham T; Scobie M; Helleday T; Berglund UW; Enerback C
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(9):4542
NEIL1 and NEIL2 Are Recruited as Potential Backup for OGG1 upon OGG1 Depletion or Inhibition by TH5487
Hanna BMF; Michel M; Helleday T; Mortusewicz O
Article: SCIENTIFIC REPORTS. 2021;11(1):6317
Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma
Oksvold MP; Berglund UW; Gad H; Bai B; Stokke T; Rein ID; Pham T; Sanjiv K; Oy GF; Norum JH; Smeland EB; Myklebust JH; Helleday T; Vatsveen TK
Article: SCIENTIFIC REPORTS. 2021;11(1):3490
Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects
Miguel Baquero J; Benitez-Buelga C; Rajagopal V; Zhao Z; Torres-Ruiz R; Mueller S; Hanna BMF; Loseva O; Wallner O; Michel M; Rodriguez-Perales S; Gad H; Visnes T; Helleday T; Benitez J; Osorio A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2021;296:100568
Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity
Rehling D; Zhang SM; Jemth A-S; Koolmeister T; Throup A; Wallner O; Scaletti E; Moriyama T; Nishii R; Davies J; Desroses M; Rudd SG; Scobie M; Homan E; Berglund UW; Yang JJ; Helleday T; Stenmark P
Article: VIRUSES-BASEL. 2020;13(1):E37-37
Broadly Active Antiviral Compounds Disturb Zika Virus Progeny Release Rescuing Virus-Induced Toxicity in Brain Organoids
Pettke A; Tampere M; Pronk R; Wallner O; Falk A; Warpman Berglund U; Helleday T; Mirazimi A; Puumalainen M-R
Article: VIRUSES-BASEL. 2020;12(12):E1423-1423
Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses
Tampere M; Pettke A; Salata C; Wallner O; Koolmeister T; Cazares-Korner A; Visnes T; Hesselman MC; Kunold E; Wiita E; Kalderen C; Lightowler M; Jemth A-S; Lehtio J; Rosenquist A; Warpman-Berglund U; Helleday T; Mirazimi A; Jafari R; Puumalainen M-R
Article: NUCLEIC ACIDS RESEARCH. 2020;48(21):12234-12251
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress
Visnes T; Benitez-Buelga C; Cazares-Korner A; Sanjiv K; Hanna BMF; Mortusewicz O; Rajagopal V; Albers JJ; Hagey DW; Bekkhus T; Eshtad S; Baquero JM; Masuyer G; Wallner O; Muller S; Pham T; Gokturk C; Rasti A; Suman S; Torres-Ruiz R; Sarno A; Wiita E; Homan EJ; Karsten S; Marimuthu K; Michel M; Koolmeister T; Scobie M; Loseva O; Almlof I; Unterlass JE; Pettke A; Bostrom J; Pandey M; Gad H; Herr P; Jemth A-S; El Andaloussi S; Kalderen C; Rodriguez-Perales S; Benitez J; Krokan HE; Altun M; Stenmark P; Berglund UW; Helleday T
Article: BIOMOLECULES. 2020;10(11):E1483-1483
OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions
Hanna BMF; Helleday T; Mortusewicz O
Article: NATURE CHEMICAL BIOLOGY. 2020;16(10):1120-1128
Development of a chemical probe against NUDT15
Zhang SM; Desroses M; Hagenkort A; Valerie NCK; Rehling D; Carter M; Wallner O; Koolmeister T; Throup A; Jemth A-S; Almlof I; Loseva O; Lundback T; Axelsson H; Regmi S; Sarno A; Kraemer A; Pudelko L; Brautigam L; Rasti A; Gottmann M; Wiita E; Kutzner J; Schaller T; Kalderen C; Cazares-Korner A; Page BDG; Krimpenfort R; Eshtad S; Altun M; Rudd SG; Knapp S; Scobie M; Homan EJ; Berglund UW; Stenmark P; Helleday T
Article: CANCER RESEARCH. 2020;80(17):3530-3541
MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG
Rudd SG; Gad H; Sanjiv K; Amaral N; Hagenkort A; Groth P; Strom CE; Mortusewicz O; Berglund UW; Helleday T
Article: NEOPLASIA. 2020;22(9):390-398
Ex vivo assessment of targeted therapies in a rare metastatic epithelial-myoepithelial carcinoma
Makela R; Arjonen A; Rahmanto AS; Harma V; Lehtio J; Kuopio T; Helleday T; Sangfelt O; Kononen J; Rantala JK
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2020;295(33):11656-11668
Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target
Skerlova J; Unterlass J; Gottmann M; Marttila P; Homan E; Helleday T; Jemth A-S; Stenmark P
Article: CELL DEATH AND DIFFERENTIATION. 2020;27(7):2081-2098
AXL and CAV-1 play a role for MTH1 inhibitor TH1579 sensitivity in cutaneous malignant melanoma
Das I; Gad H; Braeutigam L; Pudelko L; Tuominen R; Hoiom V; Almlof I; Rajagopal V; Hansson J; Helleday T; Brage SE; Berglund UW
Article: ORPHANET JOURNAL OF RARE DISEASES. 2020;15(1):170
High content drug screening for Fanconi anemia therapeutics
Montanuy H; Camps-Fajol C; Carreras-Puigvert J; Haggblad M; Lundgren B; Aza-Carmona M; Helleday T; Minguillon J; Surralles J
Article: CLINICAL CANCER RESEARCH. 2020;26(12):3044-3057
Gefitinib and Afatinib Show Potential Efficacy for Fanconi Anemia-Related Head and Neck Cancer
Montanuy H; Martinez-Barriocanal A; Antonio Casado J; Rovirosa L; Jose Ramirez M; Nieto R; Carrascoso-Rubio C; Riera P; Gonzalez A; Lerma E; Lasa A; Carreras-Puigvert J; Helleday T; Bueren JA; Arango D; Minguillon J; Surralles J
Article: BMC MEDICAL GENOMICS. 2020;13(1):76
MetaCNV-a consensus approach to infer accurate copy numbers from low coverage data
Friedrich S; Barbulescu R; Helleday T; Sonnhammer ELL
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2020;295(15):4761-4772
MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool
Scaletti ER; Vallin KS; Brautigam L; Sarno A; Berglund UW; Helleday T; Stenmark P; Jemth A-S
Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(4):608-623
Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics
Herr P; Bostrom J; Rullman E; Rudd SG; Vesterlund M; Lehtio J; Helleday T; Maddalo G; Altun M
Article: CANCER RESEARCH. 2020;80(7):1538-1550
Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds
Peuget S; Zhu J; Sanz G; Singh M; Gaetani M; Chen X; Shi Y; Saei AA; Visnes T; Lindstrom MS; Rihani A; Moyano-Galceran L; Carlson JW; Hjerpe E; Joneborg U; Lehti K; Hartman J; Helleday T; Zubarev R; Selivanova G
Article: EMBO MOLECULAR MEDICINE. 2020;12(3):e10419
Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy
Rudd SG; Tsesmetzis N; Sanjiv K; Paulin CBJ; Sandhow L; Kutzner J; Myrberg IH; Bunten SS; Axelsson H; Zhang SM; Rasti A; Makela P; Coggins SA; Tao S; Suman S; Branca RM; Mermelekas G; Wiita E; Lee S; Walfridsson J; Schinazi RF; Kim B; Lehtio J; Rassidakis GZ; Tamm KP; Warpman-Berglund U; Heyman M; Grander D; Lehmann S; Lundback T; Qian H; Henter J-I; Schaller T; Helleday T; Herold N
Article: EBIOMEDICINE. 2020;53:102704
TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model
Moukengue B; Brown HK; Charrier C; Battaglia S; Baud'huin M; Quillard T; Pham TM; Pateras IS; Gorgoulis VG; Helleday T; Heymann D; Berglund UW; Ory B; Lamoureux F
Article: JOURNAL OF MOLECULAR BIOLOGY. 2020;432(4):1126-1142
The First Structure of an Active Mammalian dCTPase and its Complexes With Substrate Analogs and Products
Scaletti E; Claesson M; Helleday T; Jemth A-S; Stenmark P
Article: CELL DEATH AND DIFFERENTIATION. 2020;27(2):773-789
The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity
Espinoza JA; Zisi A; Kanellis DC; Carreras-Puigvert J; Henriksson M; Huhn D; Watanabe K; Helleday T; Lindstrom MS; Bartek J
Article: FRONTIERS IN CHEMISTRY. 2020;8:443
In silicoDruggability Assessment of the NUDIX Hydrolase Protein Family as a Workflow for Target Prioritization
Michel M; Homan EJ; Wiita E; Pedersen K; Almlof I; Gustavsson A-L; Lundback T; Helleday T; Berglund UW
Article: NUCLEIC ACIDS RESEARCH. 2019;47(14):7418-7429
Restriction of AID activity and somatic hypermutation by PARP-1
Tepper S; Mortusewicz O; Czlonka E; Bello A; Schmidt A; Jeschke J; Fischbach A; Pfeil I; Petersen-Mahrt SK; Mangerich A; Helleday T; Leonhardt H; Jungnickel B
Article: ACS OMEGA. 2019;4(7):11642-11656
Computational and Experimental Druggability Assessment of Human DNA Glycosylases
Michel M; Visnes T; Homan EJ; Seashore-Ludlow B; Hedenstrom M; Wiita E; Vallin K; Paulin CBJ; Zhang J; Wallner O; Scobie M; Schmidt A; Jenmalm-Jensen A; Berglund UW; Helleday T
Article: FEBS LETTERS. 2019;593(14):1863-1873
Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs
Scaletti E; Jemth A-S; Helleday T; Stenmark P
Article: BIOCHEMISTRY. 2019;58(7):887-899
Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana
Jemth A-S; Scaletti E; Carter M; Helleday T; Stenmark P
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2019;176(3):436-450
Ex vivo culture of cells derived from circulating tumour cell xenograft to support small cell lung cancer research and experimental therapeutics
Lallo A; Gulati S; Schenk MW; Khandelwal G; Berglund UW; Pateras IS; Chester CPE; Pham TM; Kalderen C; Frese KK; Gorgoulis VG; Miller C; Blackhall F; Helleday T; Dive C
Article: THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY. 2019;11:1758835919866960
Karonudib is a promising anticancer therapy in hepatocellular carcinoma
Hua X; Sanjiv K; Gad H; Pham T; Gokturk C; Rasti A; Zhao Z; He K; Feng M; Zang Y; Zhang J; Xia Q; Helleday T; Berglund UW
Article: SCIENCE. 2018;362(6416):834-839
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation
Visnes T; Cazares-Korner A; Hao W; Wallner O; Masuyer G; Loseva O; Mortusewicz O; Wiita E; Sarno A; Manoilov A; Astorga-Wells J; Jemth A-S; Pan L; Sanjiv K; Karsten S; Gokturk C; Grube M; Homan EJ; Hanna BMF; Paulin CBJ; Pham T; Rasti A; Berglund UW; von Nicolai C; Benitez-Buelga C; Koolmeister T; Ivanic D; Iliev P; Scobie M; Krokan HE; Baranczewski P; Artursson P; Altun M; Jensen AJ; Kalderen C; Ba X; Zubarev RA; Stenmark P; Boldogh I; Helleday T
Article: NUCLEIC ACIDS RESEARCH. 2018;46(20):10888-10904
MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP
Jemth A-S; Gustafsson R; Brautigam L; Henriksson L; Vallin KSA; Sarno A; Almlof I; Homan E; Rasti A; Berglund UW; Stenmark P; Helleday T
Article: DNA REPAIR. 2018;71:118-126
Targeting BER enzymes in cancer therapy
Visnes T; Grube M; Hanna BMF; Benitez-Buelga C; Cazares-Korner A; Helleday T
Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2018;160:80-88
STAT3 differential scanning fluorimetry and differential scanning light scattering assays: Addressing a missing link in the characterization of STAT3 inhibitor interactions
Desroses M; Busker S; Astorga-Wells J; Attarha S; Kolosenko I; Zubarev RA; Helleday T; Grander D; Page BDG
Article: ONCOTARGET. 2018;9(80):35069-35084
The Cockayne syndrome protein B is involved in the repair of 5-AZA-2'-deoxycytidine-induced DNA lesions.
Burgos-Morón E; Calderón-Montaño JM; Pastor N; Höglund A; Ruiz-Castizo Á; Domínguez I; López-Lázaro M; Hajji N; Helleday T; Mateos S; Orta ML
Article: NEURO-ONCOLOGY. 2018;20(11):1475-1484
An orthotopic glioblastoma animal model suitable for high-throughput screenings
Pudelko L; Edwards S; Balan M; Nyqvist D; Al-Saadi J; Dittmer J; Almlof I; Helleday T; Brautigam L
Article: NATURE COMMUNICATIONS. 2018;9(1):3872
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination
Gustafsson NMS; Farnegardh K; Bonagas N; Ninou AH; Groth P; Wiita E; Jonsson M; Hallberg K; Lehto J; Pennisi R; Martinsson J; Norstrom C; Hollers J; Schultz J; Andersson M; Markova N; Marttila P; Kim B; Norin M; Olin T; Helleday T
Article: HUMAN MUTATION. 2018;39(9):1214-1225
Germline variation in the oxidative DNA repair genes NUDT1 and OGG1 is not associated with hereditary colorectal cancer or polyposis
Mur P; Jemth A-S; Bevc L; Amaral N; Navarro M; Valdes-Mas R; Pons T; Aiza G; Urioste M; Valencia A; Lazaro C; Moreno V; Puente XS; Stenmark P; Warpman-Berglund U; Capella G; Helleday T; Valle L
Article: CELL DEATH & DISEASE. 2018;9(8):810
A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma
Einarsdottir BO; Karlsson J; Soderberg EMV; Lindberg MF; Funck-Brentano E; Jespersen H; Brynjolfsson SF; Bagge RO; Carstam L; Scobie M; Koolmeister T; Wallner O; Stierner U; Berglund UW; Ny L; Nilsson LM; Larsson E; Helleday T; Nilsson JA
Article: RSC MEDICINAL CHEMISTRY. 2018;9(7):1105-1113
A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate
Riley AM; Unterlass JE; Konieczny V; Taylor CW; Helleday T; Potter BVL
Article: NATURE COMMUNICATIONS. 2018;9(1):2419
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity
Berglund E; Maaskola J; Schultz N; Friedrich S; Marklund M; Bergenstrahle J; Tarish F; Tanoglidi A; Vickovic S; Larsson L; Salmen F; Ogris C; Wallenborg K; Lagergren J; Stahl P; Sonnhammer E; Helleday T; Lundeberg J
Article: CELL CYCLE. 2018;17(5):568-579
Distinct mechanistic responses to replication fork stalling induced by either nucleotide or protein deprivation
Henriksson S; Groth P; Gustafsson N; Helleday T
Article: STRUCTURE. 2018;26(2):295-303.e6
Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold
Carter M; Jemth A-S; Carreras-Puigvert J; Herr P; Carranza MM; Vallin KSA; Throup A; Helleday T; Stenmark P
Article: BIOCHEMISTRY. 2018;57(5):593-603
Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity
Narwal M; Jemth A-S; Gustafsson R; Almlof I; Berglund UW; Helleday T; Stenmark P
Article: ACTA ONCOLOGICA. 2018;57(2):187-194
U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden
Glimelius B; Melin B; Enblad G; Alafuzoff I; Beskow A; Ahlstrom H; Bill-Axelson A; Birgisson H; Bjor O; Edqvist P-H; Hansson T; Helleday T; Hellman P; Henriksson K; Hesselager G; Hultdin M; Haggman M; Hoglund M; Jonsson H; Larsson C; Lindman H; Ljuslinder I; Mindus S; Nygren P; Ponten F; Riklund K; Rosenquist R; Sandin F; Schwenk JM; Stenling R; Stalberg K; Stalberg P; Sundstrom C; Karlsson CT; Westermark B; Bergh A; Claesson-Welsh L; Palmqvist R; Sjoblom T
Article: NATURE COMMUNICATIONS. 2018;9(1):250
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
Page BDG; Valerie NCK; Wright RHG; Wallner O; Isaksson R; Carter M; Rudd SG; Loseva O; Jemth A-S; Almlof I; Font-Mateu J; Llona-Minguez S; Baranczewski P; Jeppsson F; Homan E; Almqvist H; Axelsson H; Regmi S; Gustavsson A-L; Lundback T; Scobie M; Stromberg K; Stenmark P; Beato M; Helleday T
Article: PLOS ONE. 2018;13(1):e0191231
Citrullinated histone H3 as a novel prognostic blood marker in patients with advanced cancer
Thalin C; Lundstrom S; Seignez C; Daleskog M; Lundstrom A; Henriksson P; Helleday T; Phillipson M; Wallen H; Demers M
Article: NATURE COMMUNICATIONS. 2017;8(1):1541
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family
Carreras-Puigvert J; Zitnik M; Jemth A-S; Carter M; Unterlass JE; Hallstrom B; Loseva O; Karem Z; Calderon-Montano JM; Lindskog C; Edqvist P-H; Matuszewski DJ; Blal HA; Berntsson RPA; Haggblad M; Martens U; Studham M; Lundgren B; Wahlby C; Sonnhammer ELL; Lundberg E; Stenmark P; Zupan B; Helleday T
Article: ONCOTARGET. 2017;8(49):84671-84684
Glioblastoma and glioblastoma stem cells are dependent on functional MTH1
Pudelko L; Rouhi P; Sanjiv K; Gad H; Kalderen C; Hoglund A; Squatrito M; Schuhmacher AJ; Edwards S; Hagerstrand D; Berglund UW; Helleday T; Brautigam L
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2017;60(19):8160-8169
Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space
Rudling A; Gustafsson R; Almlof I; Homan E; Scobie M; Berglund UW; Helleday T; Stenmark P; Carlsson J
Article: ORGANIC & BIOMOLECULAR CHEMISTRY. 2017;15(37):7758-7764
Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction
Llona-Minguez S; Throup A; Steiner E; Lightowler M; Van der Haegen S; Homan E; Eriksson L; Stenmark P; Jenmalm-Jensen A; Helleday T
Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2017;27(18):4462-4466
Tetrahydrobenzothiophene carboxamides: Beyond the kinase domain and into the fatty acid realm
Llona-Minguez S; Fayezi S; Alihemmati A; Juarez-Jimenez J; Piedrafita FJ; Helleday T
Article: DNA REPAIR. 2017;57:116-124
Zebularine induces replication-dependent double-strand breaks which are preferentially repaired by homologous recombination
Luis Orta M; Pastor N; Burgos-Moron E; Dominguez I; Manuel Calderon-Montano J; Huertas Castano C; Lopez-Lazaro M; Helleday T; Mateos S
Article: NATURE COMMUNICATIONS. 2017;8(1):374
Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer
Asim M; Tarish F; Zecchini HI; Sanjiv K; Gelali E; Massie CE; Baridi A; Warren AY; Zhao W; Ogris C; McDuffus L-A; Mascalchi P; Shaw G; Dev H; Wadhwa K; Wijnhoven P; Forment JV; Lyons SR; Lynch AG; O'Neill C; Zecchini VR; Rennie PS; Baniahmad A; Tavare S; Mills IG; Galanty Y; Crosetto N; Schultz N; Neal D; Helleday T
Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2017;27(16):3897-3904
Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 1: Triazoles, triazolopyrimidines, triazinoindoles, quinoline hydrazones and arylpiperazines
Llona-Minguez S; Haggblad M; Martens U; Throup A; Loseva O; Jemth A-S; Lundgren B; Scobie M; Helleday T
Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2017;27(15):3219-3225
Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems
Llona-Minguez S; Haggblad M; Martens U; Johansson L; Sigmundsson K; Lundback T; Loseva O; Jemth A-S; Lundgren B; Jensen AJ; Scobie M; Helleday T
Article: EXPERIMENTAL HEMATOLOGY. 2017;52:32-39
With me or against me: Tumor suppressor and drug resistance activities of SAMHD 1
Herold N; Rudd SG; Sanjiv K; Kutzner J; Myrberg IH; Paulin CBJ; Olsen TK; Helleday T; Henter J-I; Schaller T
Article: EMBO JOURNAL. 2017;36(14):2161-2176
ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration
Jaiswal H; Benada J; Mullers E; Akopyan K; Burdova K; Koolmeister T; Helleday T; Medema RH; Macurek L; Lindqvist A
Article: BIOMOLECULES. 2017;7(3):E49-49
Mutations in Cancer Cause Gain of Cysteine, Histidine, and Tryptophan at the Expense of a Net Loss of Arginine on the Proteome Level
Tsuber V; Kadamov Y; Brautigam L; Berglund UW; Helleday T
Article: RSC MEDICINAL CHEMISTRY. 2017;8(7):1553-1560
Structure-metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines
Llona-Minguez S; Ghassemian A; Baranczewski P; Desroses M; Koolmeister T; Artursson P; Scobie M; Helleday T
Article: CELL CYCLE. 2017;16(11):1029-1038
SAMHD1 protects cancer cells from various nucleoside-based antimetabolites
Herold N; Rudd SG; Sanjiv K; Kutzner J; Bladh J; Paulin CBJ; Helleday T; Henter J-I; Schaller T
Article: IMMUNOLOGIC RESEARCH. 2017;65(3):706-712
Validation of an enzyme-linked immunosorbent assay for the quantification of citrullinated histone H3 as a marker for neutrophil extracellular traps in human plasma
Thalin C; Daleskog M; Goransson SP; Schatzberg D; Lasselin J; Laska A-C; Kallner A; Helleday T; Wallen H; Demers M
Article: NATURE CHEMICAL BIOLOGY. 2017;13(6):681-690
Global survey of the immunomodulatory potential of common drugs
Vladimer GI; Snijder B; Krall N; Bigenzahn JW; Huber KVM; Lardeau C-H; Sanjiv K; Ringler A; Berglund UW; Sabler M; de la Fuente OL; Knoebl P; Kubicek S; Helleday T; Jaeger U; Superti-Furga G
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2017;60(10):4279-4292
Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors
Llona-Minguez S; Hoglund A; Ghassemian A; Desroses M; Calderon-Montano JM; Moron EB; Valerie NCK; Wiita E; Almlof I; Koolmeister T; Mateus A; Cazares-Korner C; Sanjiv K; Homan E; Loseva O; Baranczewski P; Darabi M; Mehdizadeh A; Fayezi S; Jemth A-S; Berglund UW; Sigmundsson K; Lundback T; Jensen AJ; Artursson P; Scobie M; Helleday T
Article: ONCOTARGET. 2017;8(14):23713-23726
dUTPase inhibition augments replication defects of 5-Fluorouracil
Hagenkort A; Paulin CBJ; Desroses M; Sarno A; Wiita E; Mortusewicz O; Koolmeister T; Loseva O; Jemth A-S; Almlof I; Homan E; Lundback T; Gustavsson A-L; Scobie M; Helleday T
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2017;60(5):2148-2154
Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1
Llona-Minguez S; Hoglund A; Wiita E; Almlof I; Mateus A; Calderon-Montano JM; Cazares-Korner C; Homan E; Loseva O; Baranczewski P; Jemth A-S; Haggblad M; Martens U; Lundgren B; Artursson P; Lundback T; Jensen AJ; Berglund UW; Scobie M; Helledayt T
Article: CANCER RESEARCH. 2017;77(4):937-948
Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor
Gustafsson R; Jemth A-S; Gustafsson NMS; Farnegardh K; Loseva O; Wiita E; Bonagas N; Dahllund L; Llona-Minguez S; Haggblad M; Henriksson M; Andersson Y; Homan E; Helleday T; Stenmark P
Article: NATURE MEDICINE. 2017;23(2):256-263
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies
Herold N; Rudd SG; Ljungblad L; Sanjiv K; Myrberg IH; Paulin CBJ; Heshmati Y; Hagenkort A; Kutzner J; Paget BDG; Calderon-Montano JM; Loseva O; Jemth A-S; Bulli L; Axelsson H; Tesi B; Valerie NCK; Hoglund A; Bladh J; Wiita E; Sundin M; Uhlin M; Rassidakis G; Heyman M; Tamm KP; Warpman-Berglund U; Walfridsson J; Lehmann S; Grander D; Lundback T; Kogner P; Henter J-I; Helleday T; Schaller T
Article: NUCLEIC ACIDS RESEARCH. 2017;45(2):e8
A novel method for crosstalk analysis of biological networks: improving accuracy of pathway annotation
Ogris C; Guala D; Helleday T; Sonnhammer ELL
Article: CELL CYCLE. 2017;16(2):189-199
Genome-wide screen of cell-cycle regulators in normal and tumor cells identifies a differential response to nucleosome depletion
Sokolova M; Turunen M; Mortusewicz O; Kivioja T; Herr P; Vaharautio A; Bjorklund M; Taipale M; Helleday T; Taipale J
Article: PLOS ONE. 2017;12(6):e0178844
Identification of novel small molecules that inhibit STAT3-dependent transcription and function
Kolosenko I; Yu Y; Busker S; Dyczynski M; Liu J; Haraldsson M; Apergi CP; Helleday T; Tamm KP; Page BDG; Grander D
Article: ONCOGENESIS. 2016;5(12):e280
The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing
Tanikawa M; Sanjiv K; Helleday T; Herr P; Mortusewicz O
Article: ONCOGENESIS. 2016;5(12):e275
hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia
Eshtad S; Mavajian Z; Rudd SG; Visnes T; Bostrom J; Altun M; Helleday T
Article: ANNALS OF ONCOLOGY. 2016;27(12):2275-2283
Validation and development of MTH1 inhibitors for treatment of cancer
Berglund UW; Sanjiv K; Gad H; Kalderen C; Koolmeister T; Pham T; Gokturk C; Jafari R; Maddalo G; Seashore-Ludlow B; Chernobrovkin A; Manoilov A; Pateras IS; Rasti A; Jemth A-S; Almlof I; Loseva O; Visnes T; Einarsdottir BO; Gaugaz FZ; Saleh A; Platzack B; Wallner OA; Vallin KSA; Henriksson M; Wakchaure P; Borhade S; Herr P; Kallberg Y; Baranczewski P; Homan EJ; Wiita E; Nagpal V; Meijer T; Schipper N; Rudd SG; Brautigam L; Lindqvist A; Filppula A; Lee T-C; Artursson P; Nilsson JA; Gorgoulis VG; Lehtio J; Zubarev RA; Scobie M; Helleday T
Article: CANCER RESEARCH. 2016;76(18):5501-5511
NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine
Valerie NCK; Hagenkort A; Page BDG; Masuyer G; Rehling D; Carter M; Bevc L; Herr P; Homan E; Sheppard NG; Stenmark P; Jemth A-S; Helleday T
Article: NUCLEIC ACIDS RESEARCH. 2016;44(W1):W105-W109
PathwAX: a web server for network crosstalk based pathway annotation
Ogris C; Helleday T; Sonnhammer ELL
Article: CELL DEATH & DISEASE. 2016;7(6):e2267
Overexpression of the scaffold WD40 protein WRAP53β enhances the repair of and cell survival from DNA double-strand breaks
Rassoolzadeh H; Bohm S; Hedstrom E; Gad H; Helleday T; Henriksson S; Farnebo M
Article: CANCER RESEARCH. 2016;76(8):2366-2375
Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition
Brautigam L; Pudelko L; Jemth A-S; Gad H; Narwal M; Gustafsson R; Karsten S; Puigvert JC; Homan E; Berndt C; Berglund UW; Stenmark P; Helleday T
Article: CANCER RESEARCH. 2016;76(5):1078-1088
DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair
Ying S; Chen Z; Medhurst AL; Neal JA; Bao Z; Mortusewicz O; McGouran J; Song X; Shen H; Hamdy FC; Kessler BM; Meek K; Helleday T
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2016;59(3):1140-1148
Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1
Llona-Minguez S; Hoglund A; Jacques SA; Johanson L; Calderon-Montano JM; Claesson M; Loseva O; Valerie NCK; Lundback T; Piedrafita J; Maga G; Crespan E; Meijer L; Moron EB; Baranczewski P; Hagbjork A-L; Svensson R; Wiita E; Almlof I; Visnes T; Jeppsson F; Sigmundsson K; Jensen AJ; Artursson P; Jemth A-S; Stenmark P; Berglund UW; Scobie M; Helleday T
Article: ONCOGENE. 2016;35(6):761-770
PC4 promotes genome stability and DNA repair through binding of ssDNA at DNA damage sites
Mortusewicz O; Evers B; Helleday T
Article: CELL REPORTS. 2016;14(2):298-309
Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities
Sanjiv K; Hagenkort A; Calderon-Montano JM; Koolmeister T; Reaper PM; Mortusewicz O; Jacques SA; Kuiper RV; Schultz N; Scobie M; Charlton PA; Pollard JR; Berglund UW; Altun M; Helleday T
Article: ONCOTARGET. 2015;6(35):37638-37646
Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response
Xing M; Wang X; Palmai-Pallag T; Shen H; Helleday T; Hickson ID; Ying S
Article: SCIENCE TRANSLATIONAL MEDICINE. 2015;7(312):312re11
Castration radiosensitizes prostate cancer tissue by impairing DNA double-strand break repair
Tarish FL; Schultz N; Tanoglidi A; Hamberg H; Letocha H; Karaszi K; Hamdy FC; Granfors T; Helleday T
Article: MOLECULAR CELL. 2015;60(1):163-176
Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair
Xie S; Mortusewicz O; Ma HT; Herr P; Poon RRY; Helleday T; Qian C
Article: MOLECULAR CELL. 2015;59(6):984-997
PARP1-and CTCF-Mediated Interactions between Active and Repressed Chromatin at the Lamina Promote Oscillating Transcription
Zhao H; Sifakis EG; Sumida N; Millan-Arino L; Scholz BA; Svensson JP; Chen X; Ronnegren AL; de Lima CDM; Varnoosfaderani FS; Shi C; Loseva O; Yammine S; Israelsson M; Rathje L-S; Nemeti B; Fredlund E; Helleday T; Imreh MP; Gondor A
Article: DNA REPAIR. 2015;33:101-110
Addiction to MTH1 protein results in intense expression in human breast cancer tissue as measured by liquid chromatography-isotope-dilution tandem mass spectrometry
Coskun E; Jaruga P; Jemth A-S; Loseva O; Scanlan LD; Tona A; Lowenthal MS; Helleday T; Dizdaroglu M
Article: NATURE COMMUNICATIONS. 2015;6:7871
Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2
Carter M; Jemth A-S; Hagenkort A; Page BDG; Gustafsson R; Griese JJ; Gad H; Valerie NCK; Desroses M; Bostrom J; Berglund UW; Helleday T; Stenmark P
Article: BIOCHEMICAL JOURNAL. 2015;468(2):293-301
Processing of protein ADP-ribosylation by Nudix hydrolases
Palazzo L; Thomas B; Jemth A-S; Colby T; Leidecker O; Feijs KLH; Zaja R; Loseva O; Puigvert JC; Matic I; Helleday T; Ahel I
Article: CHEMISTRY-A EUROPEAN JOURNAL. 2015;21(20):7394-7398
Vinylic MIDA Boronates: New Building Blocks for the Synthesis of Aza-Heterocycles
Llona-Minguez S; Desroses M; Ghassemian A; Jacques SA; Eriksson L; Isacksson R; Koolmeister T; Stenmark P; Scobie M; Helleday T
Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2015;104:1-11
Development and validation of method for TH588 and TH287, potent MTH1 inhibitors and new anti-cancer agents, for pharmacokinetic studies in mice plasma
Saleh A; Gokturk C; Warpman-Berglund U; Helleday T; Granelli I
Article: CELL DISCOVERY. 2015;1:15034
A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair
Herr P; Lundin C; Evers B; Ebner D; Bauerschmidt C; Kingham G; Palmai-Pallag T; Mortusewicz O; Frings O; Sonnhammer E; Helleday T
Article: GENES & DEVELOPMENT. 2014;28(24):2726-2738
The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair
Henriksson S; Rassoolzadeh H; Hedstrom E; Coucoravas C; Julner A; Goldstein M; Imreh G; Zhivotovsky B; Kastan MB; Helleday T; Farnebo M
Article: NUCLEIC ACIDS RESEARCH. 2014;42(14):9108-9120
The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions
Luis Orta M; Hoglund A; Manuel Calderon-Montano J; Dominguez I; Burgos-Moron E; Visnes T; Pastor N; Strom C; Lopez-Iazaro M; Helleday T
Article: PROTEOMES. 2014;2(3):341-362
Chronic Low Dose Rate Ionizing Radiation Exposure Induces Premature Senescence in Human Fibroblasts that Correlates with Up Regulation of Proteins Involved in Protection against Oxidative Stress.
Loseva O; Shubbar E; Haghdoost S; Evers B; Helleday T; Harms-Ringdahl M
Article: CELL REPORTS. 2014;7(6):2006-2018
SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability
Pfister SX; Ahrabi S; Zalmas L-P; Sarkar S; Aymard F; Bachrati CZ; Helleday T; Legube G; La Thangue NB; Porter ACG; Humphrey TC
Article: SCIENTIFIC REPORTS. 2014;4:5372
Rational design and validation of a Tip60 histone acetyltransferase inhibitor
Gao C; Bourke E; Scobie M; Famme MA; Koolmeister T; Helleday T; Eriksson LA; Lowndes NF; Brown JAL
Article: NUCLEIC ACIDS RESEARCH. 2014;42(10):6326-6336
Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks
Bolderson E; Petermann E; Croft L; Suraweera A; Pandita RK; Pandita TK; Helleday T; Khanna KK; Richard DJ
Article: NATURE. 2014;508(7495):222-227
Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy
Huber KVM; Salah E; Radic B; Gridling M; Elkins JM; Stukalov A; Jemth A-S; Gokturk C; Sanjiv K; Stromberg K; Pham T; Berglund UW; Colinge J; Bennett KL; Loizou JI; Helleday T; Knapp S; Superti-Furga G
Article: NATURE. 2014;508(7495):215-221
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
Gad H; Koolmeister T; Jemth A-S; Eshtad S; Jacques SA; Strom CE; Svensson LM; Schultz N; Lundback T; Einarsdottir BO; Saleh A; Gokturk C; Baranczewski P; Svensson R; Berntsson RP-A; Gustafsson R; Stromberg K; Sanjiv K; Jacques-Cordonnier M-C; Desroses M; Gustavsson A-L; Olofsson R; Johansson F; Homan EJ; Loseva O; Brautigam L; Johansson L; Hoglund A; Hagenkort A; Pham T; Altun M; Gaugaz FZ; Vikingsson S; Evers B; Henriksson M; Vallin KSA; Wallner OA; Hammarstrom LGJ; Wiita E; Almlof I; Kalderen C; Axelsson H; Djureinovic T; Puigvert JC; Haggblad M; Jeppsson F; Martens U; Lundin C; Lundgren B; Granelli I; Jensen AJ; Artursson P; Nilsson JA; Stenmark P; Scobie M; Berglund UW; Helleday T
Article: SCIENCE. 2014;343(6166):88-91
Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells
Costantino L; Sotiriou SK; Rantala JK; Magin S; Mladenov E; Helleday T; Haber JE; Iliakis G; Kallioniemi OP; Halazonetis TD
Article: CELL CYCLE. 2013;12(24):3770-3780
SMG-1 suppresses CDK2 and tumor growth by regulating both the p53 and Cdc25A signaling pathways
Gubanova E; Issaeva N; Gokturk C; Djureinovic T; Helleday T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(42):16856-16861
Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity
Koepper F; Bierwirth C; Schoen M; Kunze M; Elvers I; Kranz D; Saini P; Menon MB; Walter D; Sorensen CS; Gaestel M; Helleday T; Schoen MP; Dobbelstein M
Article: CELL CYCLE. 2013;12(18):3037-3051
E2F-7 couples DNA damage-dependent transcription with the DNA repair process
Zalmas L-P; Coutts AS; Helleday T; La Thangue NB
Article: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2013;2013(26):5879-5885
A Convenient Microwave-Assisted Propylphosphonic Anhydride (T3P^®) Mediated One-Pot Pyrazolone Synthesis
Desroses M; Jacques-Cordonnier M-C; Llona-Minguez S; Jacques S; Koolmeister T; Helleday T; Scobie M
Article: ONCOGENE. 2013;32(32):3744-3753
Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress
Jones RM; Mortusewicz O; Afzal I; Lorvellec M; Garcia P; Helleday T; Petermann E
Article: RADIOTHERAPY AND ONCOLOGY. 2013;108(1):155-161
Homologous recombination mediates cellular resistance and fraction size sensitivity to radiation therapy
Somaiah N; Yarnold J; Lagerqvist A; Rothkamm K; Helleday T
Article: TETRAHEDRON LETTERS. 2013;54(27):3554-3557
A facile and efficient synthesis of tetrahydro-β-carbolines
Desroses M; Koolmeister T; Jacques S; Llona-Minguez S; Jacques-Cordonnier M-C; Cazares-Korner A; Helleday T; Scobie M
Article: NUCLEIC ACIDS RESEARCH. 2013;41(11):5827-5836
5-Aza-2'-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair
Luis Orta M; Manuel Calderon-Montano J; Dominguez I; Pastor N; Burgos-Moron E; Lopez-Lazaro M; Cortes F; Mateos S; Helleday T
Article: CLINICAL CANCER RESEARCH. 2013;19(6):1547-1556
Castration Therapy Results in Decreased Ku70 Levels in Prostate Cancer
Al-Ubaidi FLT; Schultz N; Loseva O; Egevad L; Granfors T; Helleday T
Article: NATURE. 2013;494(7438):492-496
Replication stress links structural and numerical cancer chromosomal instability
Burrell RA; McClelland SE; Endesfelder D; Groth P; Weller M-C; Shaikh N; Domingo E; Kanu N; Dewhurst SM; Gronroos E; Chew SK; Rowan AJ; Schenk A; Sheffer M; Howell M; Kschischo M; Behrens A; Helleday T; Bartek J; Tomlinson IR; Swanton C
Article: CARCINOGENESIS. 2013;34(2):325-330
Genotoxicity of alcohol is linked to DNA replication-associated damage and homologous recombination repair
Kotova N; Vare D; Schultz N; Meesters DG; Stepnik M; Grawe J; Helleday T; Jenssen D
Article: CARCINOGENESIS. 2013;34(1):139-145
DNA damage response in peritumoral regions of oesophageal cancer microenvironment
He H; Tian D; Guo J; Liu M; Chen Z; Hamdy FC; Helleday T; Su M; Ying S
Article: NEW JOURNAL OF CHEMISTRY. 2013;37(11):3595-3597
A new concise synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives
Desroses M; Scobie M; Helleday T
Article: BIOMOLECULES. 2012;2(4):635-649
Strategies for the Use of Poly(adenosine diphosphate ribose) Polymerase (PARP) Inhibitors in Cancer Therapy.
Ström CE; Helleday T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(50):42206-42222
Targeting Protein for Xenopus Kinesin-like Protein 2 (TPX2) Regulates γ-Histone 2AX (γ-H2AX) Levels upon Ionizing Radiation
Neumayer G; Helfricht A; Shim SY; Hoa TL; Lundin C; Belzil C; Chansard M; Yu Y; Lees-Miller SP; Gruss OJ; van Attikum H; Helleday T; Minh DN
Article: CARCINOGENESIS. 2012;33(11):2026-2034
Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta
Nicolay NH; Carter R; Hatch SB; Schultz N; Prevo R; McKenna WG; Helleday T; Sharma RA
Article: CLINICAL CANCER RESEARCH. 2012;18(19):5479-5488
The Relationship Between Homologous Recombination Repair and the Sensitivity of Human Epidermis to the Size of Daily Doses Over a 5-Week Course of Breast Radiotherapy
Somaiah N; Yarnold J; Daley F; Pearson A; Gothard L; Rothkamm K; Helleday T
Article: NUCLEIC ACIDS RESEARCH. 2012;40(17):8440-8448
CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation
Elvers I; Hagenkort A; Johansson F; Djureinovic T; Lagerqvist A; Schultz N; Stoimenov I; Erixon K; Helleday T
Article: NUCLEIC ACIDS RESEARCH. 2012;40(14):6585-6594
Homologous recombination repairs secondary replication induced DNA double-strand breaks after ionizing radiation
Groth P; Luis Orta M; Elvers I; Majumder MM; Lagerqvist A; Helleday T
Article: CANCER RESEARCH. 2012;72(11):2814-2821
Mre11-Dependent Degradation of Stalled DNA Replication Forks Is Prevented by BRCA2 and PARP1
Ying S; Hamdy FC; Helleday T
Article: BIOCHEMICAL PHARMACOLOGY. 2012;83(11):1514-1522
Minor structural modifications to alchemix influence mechanism of action and pharmacological activity
Abdallah QMA; Phillips RM; Johansson F; Helleday T; Cosentino L; Abdel-Rahman H; Etzad J; Wheelhouse RT; Kiakos K; Bingham JP; Hartley JA; Patterson LH; Pors K
Article: LIPIDS. 2012;47(4):355-361
N-Acyl Taurines are Anti-Proliferative in Prostate Cancer Cells
Chatzakos V; Slatis K; Djureinovic T; Helleday T; Hunt MC
Article: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2012;53(2):114-124
Uncoupling of RAD51 focus formation and cell survival after replication fork stalling in RAD51D null CHO cells
Urbin SS; Elvers I; Hinz JM; Helleday T; Thompson LH
Article: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 2012;82(3):1243-1248
CASTRATION THERAPY OF PROSTATE CANCER RESULTS IN DOWNREGULATION OF HIF-1α LEVELS
Al-Ubaidi FLT; Schultz N; Egevad L; Granfors T; Helleday T
Article: CLINICAL CANCER RESEARCH. 2012;18(5):1257-1267
Downregulation of SMG-1 in HPV-Positive Head and Neck Squamous Cell Carcinoma Due to Promoter Hypermethylation Correlates with Improved Survival
Gubanova E; Brown B; Ivanov SV; Helleday T; Mills GB; Yarbrough WG; Issaeva N
Article: CLINICAL CANCER RESEARCH. 2012;18(4):1015-1027
PTEN Deletion in Prostate Cancer Cells Does Not Associate with Loss of RAD51 Function: Implications for Radiotherapy and Chemotherapy
Fraser M; Zhao H; Luoto KR; Lundin C; Coackley C; Chan N; Joshua AM; Bismar TA; Evans A; Helleday T; Bristow RG
Article: MOLECULAR CANCER THERAPEUTICS. 2012;11(1):98-107
Targeted Mutations in the ATR Pathway Define Agent-Specific Requirements for Cancer Cell Growth and Survival
Wilsker D; Chung JH; Pradilla I; Petermann E; Helleday T; Bunz F
Article: DNA REPAIR. 2011;10(9):961-969
CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair
Strom CE; Mortusewicz O; Finch D; Parsons JL; Lagerqvist A; Johansson F; Schultz N; Erixon K; Dianov GL; Helleday T
Article: EUROPEAN JOURNAL OF CANCER. 2011;47:S333-S335
DNA repair as treatment target
Helleday T
Article: NUCLEIC ACIDS RESEARCH. 2011;39(16):7049-7057
UV stalled replication forks restart by re-priming in human fibroblasts
Elvers I; Johansson F; Groth P; Erixon K; Helleday T
Article: FEBS LETTERS. 2011;585(16):2617-2621
Crystal structure of human MTH1 and the 8-oxo-dGMP product complex
Svensson LM; Jemth A-S; Desroses M; Loseva O; Helleday T; Hoegbom M; Stenmark P
Article: RADIATION RESEARCH. 2011
Radiation Resistance in Cancer Therapy: Meeting Summary and Research Opportunities: Report of an NCI Workshop held September 1-3, 2010.
Glazer PM; Grandis J; Powell SN; Brown JM; Helleday T; Bristow R; Powis G; Hill RP; Le Q-T; Pelroy R; Mohla S; Bernhard EJ
Article: RADIATION RESEARCH. 2011;176(3):e0016-e0021
Radiation Resistance in Cancer Therapy: meeting summary and research opportunities. Report of an NCI Workshop held September 1-3, 2010.
Glazer PM; Grandis J; Powell SN; Brown JM; Helleday T; Bristow R; Powis G; Hill RP; Le Q-T; Pelroy R; Mohla S; Bernhard EJ; NCI Workshop Participants
Article: EMBO REPORTS. 2011;12(7):713-719
ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair
Segal-Raz H; Mass G; Baranes-Bachar K; Lerenthal Y; Wang S-Y; Chung YM; Ziv-Lehrman S; Strom CE; Helleday T; Hu MC-T; Chen DJ; Shiloh Y
Article: CANCER BIOLOGY & THERAPY. 2011;11(12):1028-1035
Breast cancer stem-like cells show dominant homologous recombination due to a larger S-G₂ fraction
Al-Assar O; Mantoni T; Lunardi S; Kingham G; Helleday T; Brunner TB
Article: PLOS ONE. 2011;6(5):e19659
FANCD1/BRCA2 Plays Predominant Role in the Repair of DNA Damage Induced by ACNU or TMZ
Kondo N; Takahashi A; Mori E; Noda T; Zdzienicka MZ; Thompson LH; Helleday T; Suzuki M; Kinashi Y; Masunaga S; Ono K; Hasegawa M; Ohnishi T
Article: PLOS ONE. 2011;6(5):e19492
Transcription Inhibition by DRB Potentiates Recombinational Repair of UV Lesions in Mammalian Cells
Stoimenov I; Schultz N; Gottipati P; Helleday T
Article: NUCLEIC ACIDS RESEARCH. 2011;39(8):3166-3175
Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate
Strom CE; Johansson F; Uhlen M; Szigyarto CA-K; Erixon K; Helleday T
Article: EXPERIMENTAL CELL RESEARCH. 2011;317(3):330-337
Cohesin phosphorylation and mobility of SMC1 at ionizing radiation-induced DNA double-strand breaks in human cells
Bauerschmidt C; Woodcock M; Stevens DL; Hill MA; Rothkamm K; Helleday T
Article: MOLECULAR CELL. 2011;41(2):210-220
miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors
Moskwa P; Buffa FM; Pan Y; Panchakshari R; Gottipati P; Muschel RJ; Beech J; Kulshrestha R; Abdelmohsen K; Weinstock DM; Gorospe M; Harris AL; Helleday T; Chowdhury D
Article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2011;706(1-2):1-6
Transcription inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) causes DNA damage and triggers homologous recombination repair in mammalian cells
Stoimenov I; Gottipati P; Schultz N; Helleday T
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;404(1):206-210
Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damage
Noda T; Takahashi A; Kondo N; Mori E; Okamoto N; Nakagawa Y; Ohnishi K; Zdzienicka MZ; Thompson LH; Helleday T; Asada H; Ohnishi T
Article: ONCOTARGET. 2010;1(7):606-619
Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks
Hawtin RE; Stockett DE; Wong OK; Lundin C; Helleday T; Fox JA
Article: MOLECULAR CELL. 2010;40(4):632-644
Identification of the MMS22L-TONSL Complex that Promotes Homologous Recombination
Duro E; Lundin C; Ask K; Sanchez-Pulido L; MacArtney TJ; Toth R; Ponting CP; Groth A; Helleday T; Rouse J
Article: MUTAGENESIS. 2010;25(6):623-629
The XPD subunit of TFIIH is required for transcription-associated but not DNA double-strand break-induced recombination in mammalian cells
Savolainen L; Cassel T; Helleday T
Article: CANCER RESEARCH. 2010;70(20):8045-8054
Contextual Synthetic Lethality of Cancer Cell Kill Based on the Tumor Microenvironment
Chan N; Pires IM; Bencokova Z; Coackley C; Luoto KR; Bhogal N; Lakshman M; Gottipati P; Oliver FJ; Helleday T; Hammond EM; Bristow RG
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(37):16090-16095
Chk1 promotes replication fork progression by controlling replication initiation
Petermann E; Woodcock M; Helleday T
Article: JOURNAL OF MOLECULAR BIOLOGY. 2010;402(1):70-82
Methylated DNA Causes a Physical Block to Replication Forks Independently of Damage Signalling, O⁶-Methylguanine or DNA Single-Strand Breaks and Results in DNA Damage
Groth P; Auslander S; Majumder MM; Schultz N; Johansson F; Petermann E; Helleday T
Article: DNA REPAIR. 2010;9(9):964-975
Human RECQL5 overcomes thymidine-induced replication stress
Blundred R; Myers K; Helleday T; Goldman ASH; Bryant HE
Article: CANCER RESEARCH. 2010;70(15):6268-6276
6-Thioguanine Selectively Kills BRCA2-Defective Tumors and Overcomes PARP Inhibitor Resistance
Issaeva N; Thomas HD; Djurenovic T; Jaspers JE; Stoimenov I; Kyle S; Pedley N; Gottipati P; Zur R; Sleeth K; Chatzakos V; Mulligan EA; Lundin C; Gubanova E; Kersbergen A; Harris AL; Sharma RA; Rottenberg S; Curtin NJ; Helleday T
Article: ONCOTARGET. 2010;1(3):175-184
Overexpression of POLQ Confers a Poor Prognosis in Early Breast Cancer Patients
Higgins GS; Harris AL; Prevo R; Helleday T; McKenna WG; Buffa FM
Article: CELL. 2010;142(1):65-76
Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2
MacKay C; Declais A-C; Lundin C; Agostinho A; Deans AJ; MacArtney TJ; Hofmann K; Gartner A; West SC; Helleday T; Lilley DMJ; Rouse J
Article: CANCER RESEARCH. 2010;70(13):5389-5398
Poly(ADP-Ribose) Polymerase Is Hyperactivated in Homologous Recombination-Defective Cells
Gottipati P; Vischioni B; Schultz N; Solomons J; Bryant HE; Djureinovic T; Issaeva N; Sleeth K; Sharma RA; Helleday T
Article: DNA REPAIR. 2010;9(7):835-841
XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair
Parsons JL; Dianova II; Finch D; Tait PS; Strom CE; Helleday T; Dianov GL
Article: CARCINOGENESIS. 2010;31(6):955-960
Homologous recombination in cancer development, treatment and development of drug resistance
Helleday T
Article: CANCER RESEARCH. 2010;70(7):2984-2993
A Small Interfering RNA Screen of Genes Involved in DNA Repair Identifies Tumor-Specific Radiosensitization by POLQ Knockdown
Higgins GS; Prevo R; Lee Y-F; Helleday T; Muschel RJ; Taylor S; Yoshimura M; Hickson ID; Bernhard EJ; McKenna WG
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(11):8054-8060
PARP-3 Is a Mono-ADP-ribosylase That Activates PARP-1 in the Absence of DNA
Loseva O; Jemth A-S; Bryant HE; Schuler H; Lehtio L; Karlberg T; Helleday T
Article: JOURNAL OF CELL BIOLOGY. 2010;188(5):629-638
Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase
Beck H; Nahse V; Larsen MSY; Groth P; Clancy T; Lees M; Jorgensen M; Helleday T; Syljuasen RG; Sorensen CS
Article: MOLECULAR CELL. 2010;37(4):492-502
Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair
Petermann E; Luis Orta M; Issaeva N; Schultz N; Helleday T
Article: DNA REPAIR. 2009;8(12):1424-1433
Specific targeted gene repair using single-stranded DNA oligonucleotides at an endogenous locus in mammalian cells uses homologous recombination
McLachlan J; Fernandez S; Helleday T; Bryant HE
Article: NUCLEIC ACIDS RESEARCH. 2009;37(19):6400-6413
The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links
Al-Minawi AZ; Lee Y-F; Hakansson D; Johansson F; Lundin C; Saleh-Gohari N; Schultz N; Jenssen D; Bryant HE; Meuth M; Hinz JM; Helleday T
Article: EMBO JOURNAL. 2009;28(17):2601-2615
PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination
Bryant HE; Petermann E; Schultz N; Jemth A-S; Loseva O; Issaeva N; Johansson F; Fernandez S; McGlynn P; Helleday T
Article: NUCLEIC ACIDS RESEARCH. 2009;37(15):5105-5113
BRCA2-dependent homologous recombination is required for repair of Arsenite-induced replication lesions in mammalian cells
Ying S; Myers K; Bottomley S; Helleday T; Bryant HE
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2009;52(9):3108-3111
Structural Basis for Inhibitor Specificity in Human Poly(ADP-ribose) Polymerase-3
Lehtio L; Jemth A-S; Collins R; Loseva O; Johansson A; Markova N; Hammarstrom M; Flores A; Holmberg-Schiavone L; Weigelt J; Helleday T; Schuler H; Karlberg T
Article: NUCLEIC ACIDS RESEARCH. 2009;37(2):405-412
Transcription-associated recombination is independent of XRCC2 and mechanistically separate from homology-directed DNA double-strand break repair
Savolainen L; Helleday T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(52):20752-20757
Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control
Wilsker D; Petermann E; Helleday T; Bunz F
Article: MOLECULAR BIOLOGY OF THE CELL. 2008;19(9):3923-3933
WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks
Cheng W-H; Muftic D; Muftuoglu M; Dawut L; Morris C; Helleday T; Shiloh Y; Bohr VA
Article: CLINICAL CANCER RESEARCH. 2008;14(17):5476-5483
Thymidine selectively enhances growth suppressive effects of camptothecin/irinotecan in MSI plus cells and tumors containing a mutation of MRE11
Rodriguez R; Hansen LT; Phear G; Scorah J; Spang-Thomsen M; Cox A; Helleday T; Meuth M
Article: JOURNAL OF APPLIED MICROBIOLOGY. 2008;105(1):290-299
Bacteriophage P2 integrase:: another possible tool for site-specific recombination in eukaryotic cells
Frumerie C; Sylwan L; Helleday T; Yu A; Haggard-Ljungquist E
Article: MOLECULAR BIOLOGY OF THE CELL. 2008;19(6):2373-2378
Claspin promotes normal replication fork rates in human cells
Petermann E; Helleday T; Caldecott KW
Article: JOURNAL OF MOLECULAR BIOLOGY. 2008;379(1):136-145
Zinc binding catalytic domain of human tankyrase 1
Lehtioe L; Collins R; van den Berg S; Johansson A; Dahlgren L-G; Hammarstroem M; Helleday T; Holmberg-Schiavone L; Karlberg T; Weigelt J
Article: MOLECULAR AND CELLULAR BIOLOGY. 2008;28(1):154-164
Transcription-associated recombination is dependent on replication in mammalian cells
Gottipati P; Cassel TN; Savolainen L; Helleday T
Article: NUCLEIC ACIDS RESEARCH. 2008;36(1):1-9
The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells
Al-Minawi AZ; Saleh-Gohari N; Helleday T
Article: JOURNAL OF CELL BIOLOGY. 2007;179(7):1337-1345
The histone methyltransferase SET8 is required for S-phase progression
Jorgensen S; Elvers I; Trelle MB; Menzel T; Eskildsen M; Jensen ON; Helleday T; Helin K; Sorensen CS
Article: JOURNAL OF MOLECULAR BIOLOGY. 2007;373(1):38-47
RPA mediates recombination repair during replication stress and is displaced from DNA by checkpoint signalling in human cells
Sleeth KM; Sorensen CS; Issaeva N; Dziegielewski J; Bartek J; Helleday T
Article: MOLECULAR AND CELLULAR BIOLOGY. 2007;27(7):2562-2571
RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair
Saberi A; Hochegger H; Szuts D; Lan L; Yasui A; Sale JE; Taniguchi Y; Murakawa Y; Zeng W; Yokomori K; Helleday T; Teraoka H; Arakawa H; Buerstedde J-M; Takeda S
Article: CYTOGENETIC AND GENOME RESEARCH. 2007;116(1-2):38-45
RAD51C (RAD51L2) is involved in maintaining centrosome number in mitosis
Lindh AR; Schultz N; Saleh-Gohari N; Helleday T
Article: DNA REPAIR. 2006;5(12):1449-1458
Caffeine delays replication fork progression and enhances UV-induced homologous recombination in Chinese hamster cell lines
Johansson F; Lagerqvist A; Filippi S; Palitti F; Erixon K; Helleday N; Jenssen D
Article: NATURE. 2006;444(7119):633-637
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
Bartkova J; Rezaei N; Liontos M; Karakaidos P; Kletsas D; Issaeva N; Vassiliou L-VF; Kolettas E; Niforou K; Zoumpourlis VC; Takaoka M; Nakagawa H; Tort F; Fugger K; Johansson F; Sehested M; Andersen CL; Dyrskjot L; Orntoft T; Lukas J; Kittas C; Helleday T; Halazonetis TD; Bartek J; Gorgoulis VG
Article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2006;599(1-2):116-123
Homologous recombination is involved in repair of chromium-induced DNA damage in mammalian cells
Bryant HE; Ying S; Helleday T
Article: HUMAN MOLECULAR GENETICS. 2006;15(7):1217-1224
Mitotic defects in XRCC3 variants T241M and D213N and their relation to cancer susceptibility
Lindh AR; Rafii S; Schultz N; Cox A; Helleday T
Article: NUCLEIC ACIDS RESEARCH. 2006;34(6):1685-1691
Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair
Bryant HE; Helleday T
Article: CELL CYCLE. 2005;4(9):1176-1178
Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy
Helleday T; Bryant HE; Schultz N
Article: MOLECULAR AND CELLULAR BIOLOGY. 2005;25(16):7158-7169
Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks
Saleh-Gohari N; Bryant HE; Schultz N; Parker KA; Cassel TN; Helleday T
Article: NUCLEIC ACIDS RESEARCH. 2005;33(12):3799-3811
Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks
Lundin C; North M; Erixon K; Walters K; Jenssen D; Goldman ASH; Helleday T
Article: MOLECULAR AND CELLULAR BIOLOGY. 2005;25(9):3553-3562
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
Syljuåsen RG; Sorensen CS; Hansen LT; Fugger K; Lundin C; Johansson F; Helleday T; Sehested M; Lukas J; Bartek J
Article: NATURE. 2005;434(7035):913-917
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
Bryant HE; Schultz N; Thomas HD; Parker KM; Flower D; Lopez E; Kyle S; Meuth M; Curtin NJ; Helleday T
Article: NATURE. 2005;434(7029):108-113
Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1
El-Khamisy SF; Saifi GM; Weinfeld M; Johansson F; Helleday T; Lupski JR; Caldecott KW
Article: NATURE CELL BIOLOGY. 2005;7(2):195-201
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
Sorensen CS; Hansen LT; Dziegielewski J; Syljuåsen RG; Lundin C; Bartek J; Helleday T
Article: CANCER RESEARCH. 2005;65(1):325-330
Up-regulation of the error-prone DNA polymerase κ promotes pleiotropic genetic alterations and tumorigenesis
Bavoux C; Leopoldino AM; Bergoglio V; O-Wang JY; Ogi T; Bieth A; Judde JG; Pena SDJ; Poupon MF; Helleday T; Tagawa M; Machado C; Hoffmann JS; Cazaux C
Article: ONCOGENE. 2004;23(56):9136-9141
Strand invasion involving short tract gene conversion is specifically suppressed in BRCA2-deficient hamster cells
Saleh-Gohari N; Helleday T
Article: HUMAN MOLECULAR GENETICS. 2004;13(23):2937-2945
ATM is required for the cellular response to thymidine induced replication fork stress
Bolderson E; Scorah J; Helleday T; Smythe C; Meuth M
Article: BIOCHEMICAL SOCIETY TRANSACTIONS. 2004;32(Pt 6):959-961
Poly(ADP-ribose) polymerase inhibitors as potential chemotherapeutic agents
Bryant HE; Helleday T
Article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2004;563(1):35-47
Screening for genotoxicity using the DRAG assay:: investigation of halogenated environmental contaminants
Johansson F; Allkvist A; Erixon K; Malmvärn A; Nilsson R; Bergman Å; Helleday T; Jenssen D
Article: NUCLEIC ACIDS RESEARCH. 2004;32(12):3683-3688
Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells
Saleh-Gohari N; Helleday T
Article: ONCOGENE. 2004;23(13):2324-2329
p53 protects from replication-associated DNA double-strand breaks in mammalian cells
Kumari A; Schultz N; Helleday T
Article: HUMAN MOLECULAR GENETICS. 2004;13(2):203-212
A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous recombination at DNA replication forks
Mohindra A; Bolderson E; Stone J; Wells M; Helleday T; Meuth M
Article: NUCLEIC ACIDS RESEARCH. 2003;31(17):4959-4964
Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination
Schultz N; Lopez E; Saleh-Gohari N; Helleday T
Article: INTERNATIONAL JOURNAL OF CANCER. 2003;105(4):472-479
The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer
Hansen LT; Lundin C; Spang-Thomsen M; Petersen LN; Helleday T
Article: JOURNAL OF MOLECULAR BIOLOGY. 2003;328(3):521-535
RAD51 is involved in repair of damage associated with DNA replication in mammalian cells
Lundin C; Schultz N; Arnaudeau C; Mohindra A; Hansen LT; Helleday T
Article: LUNG CANCER. 2003;40(2):157-164
DNA repair rate and etoposide (VP16) resistance of tumor cell subpopulations derived from a single human small cell lung cancer
Hansen LT; Lundin C; Helleday T; Poulsen HS; Sorensen CS; Petersen LN; Spang-Thomsen M
Article: CARCINOGENESIS. 2003;24(2):249-253
Reduced apoptotic response to camptothecin in CHO cells deficient in XRCC3
Hinz JM; Helleday T; Meuth M
Article: HUMAN MOLECULAR GENETICS. 2002;11(18):2189-2200
Defects in homologous recombination repair in mismatch-repair-deficient tumour cell lines
Mohindra A; Hays LE; Preston BD; Helleday T; Meuth M
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2002;296(2):363-367
Overexpression of cyclin E does not influence homologous recombination in Chinese hamster cells
Lundin C; Samuelsson MKR; Helleday T
Article: MOLECULAR AND CELLULAR BIOLOGY. 2002;22(16):5869-5878
Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells
Lundin C; Erixon K; Arnaudeau C; Schultz N; Jenssen D; Meuth M; Helleday T
Article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2001;493(1-2):55-66
ELF magnetic field affects proliferation of SPD8/V79 Chinese hamster cells but does not interact with intrachromosomal recombination
Olsson G; Belyaev IY; Helleday T; Harms-Ringdahl M
Article: JOURNAL OF MOLECULAR BIOLOGY. 2001;307(5):1235-1245
DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells
Arnaudeau C; Lundin C; Helleday T
Article: NUCLEIC ACIDS RESEARCH. 2001;29(3):662-667
RAD51 supports spontaneous non-homologous recombination in mammalian cells, but not the corresponding process induced by topoisomerase inhibitors
Arnaudeau C; Rozier L; Cazaux C; Defais M; Jenssen D; Helleday T
Article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2000;461(3):221-228
Inhibition of DNA synthesis is a potent mechanism by which cytostatic drugs induce homologous recombination in mammalian cells
Arnaudeau C; Miranda ET; Jenssen D; Helleday T
Article: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2000;35(2):114-122
Arsenic[III] and heavy metal ions induce intrachromosomal homologous recombination in the hprt gene of V79 Chinese hamster cells
Helleday T; Nilsson R; Jenssen D
Article: JOURNAL OF MOLECULAR BIOLOGY. 1999;289(5):1231-1238
The RAD51 protein supports homologous recombination by an exchange mechanism in mammalian cells
Arnaudeau C; Helleday T; Jenssen D
Article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 1999;439(2):137-147
Brominated flame retardants induce intragenic recombination in mammalian cells
Helleday T; Tuominen KL; Bergman A; Jenssen D
Article: JOURNAL OF MOLECULAR BIOLOGY. 1998;279(4):687-694
A partial HPRT gene duplication generated by non-homologous recombination in V79 Chinese hamster cells is eliminated by homologous recombination
Helleday T; Arnaudeau C; Jenssen D
Article: CARCINOGENESIS. 1998;19(6):973-978
Effects of carcinogenic agents upon different mechanisms for intragenic recombination in mammalian cells
Helleday T; Arnaudeau C; Jenssen D
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Review: EXPERT REVIEW OF CLINICAL IMMUNOLOGY. 2024;20(8):821-838
In-vitro assays for immuno-oncology drug efficacy assessment and screening for personalized cancer therapy: scopes and challenges
Rahman MM; Wells G; Rantala JK; Helleday T; Muthana M; Danson SJ
Review: CANCER RESEARCH. 2024;84(1):9-16
Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response
Ramos L; Henriksson M; Helleday T; Green AC
Review: MOLECULAR ONCOLOGY. 2022;16(21):3792-3810
Targeting the DNA damage response and repair in cancer through nucleotide metabolism
Helleday T; Rudd SG
Review: EXPERT REVIEWS IN MOLECULAR MEDICINE. 2022;24:e39
Precision oncology using ex vivo technology: a step towards individualised cancer care?
Williams ST; Wells G; Conroy S; Gagg H; Allen R; Rominiyi O; Helleday T; Hullock K; Pennington CEW; Rantala J; Collis SJ; Danson SJ
Editorial comment: CLINICAL AND TRANSLATIONAL MEDICINE. 2022;12(8):e1035
Synthetic switches of OGG1 control initiation of base excision repair and offer new treatment strategies
Benitez-Buelga C; Helleday T; Michel M
Meeting abstract: CANCER RESEARCH. 2022;82(10):pr016
The spatial landscape of clonal somatic mutations in benign and malignant tissue
Erickson A; Berglund E; He M; Marklund M; Mirzazadeh R; Schultz N; Bergenstrahle L; Kvastad L; Andersson A; Bergenstrahle J; Larsson L; Shamikh A; Basmaci E; De Stahl TD; Rajakumar T; Thrane K; Ji AL; Khavari PA; Tarish F; Tanoglidi A; Maaskola J; Colling R; Mirtti T; Hamdy FC; Woodcock DJ; Helleday T; Mills IG; Lamb AD
Editorial comment: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(3 PT A):736-740.e6
Coexpression of MTH1 and PMS2 Is Associated with Advanced Disease and Disease Progression after Therapy in Melanoma
Das I; Tuominen R; Helleday T; Hansson J; Berglund UW; Brage SE
Editorial comment: CLINICAL CANCER RESEARCH. 2021;27(21):6066
Editor's Note: Castration Therapy Results in Decreased Ku70 Levels in Prostate Cancer.
Al-Ubaidi FLT; Schultz N; Loseva O; Egevad L; Granfors T; Helleday T
Editorial comment: NATURE CANCER. 2021;2(6):581-583
Polθ inhibitors unchained
Helleday T
Meeting abstract: BLOOD. 2020;136:18-19
Karonudib Has Potent Anti-Tumor Effects in Preclinical Models of B-Cell Lymphoma
Oksvold MP; Berglund UW; Gad H; Bai B; Stokke T; Rein ID; Pham T; Sanjiv K; Oy GF; Norum JH; Smeland EB; Myklebust JH; Helleday T; Vatsveen TK
Meeting abstract: CANCER RESEARCH. 2020;80(16):5204
Targeting OGG1 arrest cancer cell proliferationby mitochondrial dysfunction and replication stress
Benitez-Buelga C; Visnes T; Sanjiv K; Mortusewicz O; Berglund UW; Helleday T
Meeting abstract: CANCER RESEARCH. 2020;80(16):4799
OGG1 depleted cancer cells are sensitive to anti-malarial drug proguanil: Repurposing for cancer treatment
Rajagopal V; Marimuthu K; Benitez-Buelga C; Wallner O; Homan E; Scobie M; Kalderen C; Helleday T; Berglund UW; Sanjiv K
Meeting abstract: CANCER RESEARCH. 2020;80(16):1057
Targeting MTHFD2 using first-in-class inhibitors kills haematological and solid cancer through thymineless-induced replication stress
Helleday T
Editorial comment: ANNALS OF ONCOLOGY. 2020;31(5):553-555
Managing COVID-19 in the oncology clinic and avoiding the distraction effect
Cortiula F; Pettke A; Bartoletti M; Puglisi F; Helleday T
Corrigendum: ONCOTARGET. 2020;11(8):827
Correction: Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.
Pudelko L; Rouhi P; Sanjiv K; Gad H; Kalderén C; Höglund A; Squatrito M; Schuhmacher AJ; Edwards S; Hägerstrand D; Berglund UW; Helleday T; Bräutigam L
Meeting abstract: CANCER RESEARCH. 2020;80(4):es12-2-es12-2
Targeted DNA repair in cancer and new NUDT5 inhibitors to block hormone signalling to target breast cancer
Helleday T
Corrigendum: CELL DEATH & DISEASE. 2020;11(2):99
Correction: A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma.
Einarsdottir BO; Karlsson J; Söderberg EMV; Lindberg MF; Funck-Brentano E; Jespersen H; Brynjolfsson SF; Bagge RO; Carstam L; Scobie M; Koolmeister T; Wallner O; Stierner U; Berglund UW; Ny L; Nilsson LM; Larsson E; Helleday T; Nilsson JA
Editorial comment: ANNALS OF ONCOLOGY. 2020;31(2):167-168
Using personalized immune-humanized xenograft mouse models to predict immune checkpoint responses in malignant melanoma: potential and hurdles
Helleday T
Corrigendum: NATURE COMMUNICATIONS. 2019;10(1):5050
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells (vol 9, 250, 2018)
Page BDG; Valerie NCK; Wright RHG; Wallner O; Isaksson R; Carter M; Rudd SG; Loseva O; Jemth A-S; Almlof I; Font-Mateu J; Llona-Minguez S; Baranczewski P; Jeppsson F; Homan E; Almqvist H; Axelsson H; Regmi S; Gustavsson A-L; Lundback T; Scobie M; Stromberg K; Stenmark P; Beato M; Helleday T
Meeting abstract: ANNALS OF ONCOLOGY. 2019;30:vii8
Therapeutic implications of MTH1 inhibitor TH1579 in cutaneous malignant melanoma
Das I; Gad H; Brautigam L; Pudelko L; Tuominen R; Hoiom V; Almlof I; Hansson J; Helleday T; Brage SE; Berglund UW
Meeting abstract: CANCER RESEARCH. 2019;79(13):105
MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells
Sanjiv K; Gad H; Rudd SG; Mortusewicz O; Stolz A; Amaral N; Brautigham L; Pudelko L; Kalderen C; Jemth A-S; Almlof I; Visnes T; Schultz N; Bostrom J; Montano JMC; Hagenkort A; Groth P; Gokturk C; Koolmeister T; Wakchaure P; Homan E; Altun M; Strom C; Scobie M; Bastians H; Berglund UW; Helleday T
Editorial comment: ANNALS OF ONCOLOGY. 2019;30(3):360-361
Making immunotherapy "cold' tumours "hot' by chemotherapy-induced mutationsa misconception
Helleday T
Review: AMERICAN SOCIETY OF CLINICAL ONCOLOGY EDUCATIONAL BOOK / ASCO. AMERICAN SOCIETY OF CLINICAL ONCOLOGY. MEETING. 2019;39:185-195
The DNA Damaging Revolution: PARP Inhibitors and Beyond.
Yap TA; Plummer R; Azad NS; Helleday T
Review: EMBO REPORTS. 2018;19(9):e46263
Mechanisms for stalled replication fork stabilization: new targets for synthetic lethality strategies in cancer treatments
Liao H; Ji F; Helleday T; Ying S
Meeting abstract: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2018;138(5):S200
Effects of MTH1 inhibitor TH1579 on cutaneous melanoma
Das I; Gad H; Pudelko L; Brautigam L; Tuominen R; Helleday T; Hansson J; Brage S; Berglund U
Corrigendum: JOURNAL OF MEDICINAL CHEMISTRY. 2017;60(17):7614
Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors (vol 60, pg 4279, 2017)
Llona-Minguez S; Hoglund A; Ghassemian A; Desroses M; Calderon-Montano JM; Moron EB; Valerie NCK; Wiita E; Almlof I; Koolmeister T; Mateus A; Cazares-Korner C; Sanjiv K; Homan E; Loseva O; Baranczewski P; Darabi M; Mehdizadeh A; Fayezi S; Jemth A-S; Berglund UW; Sigmundsson K; Lundback T; Jensen AJ; Artursson P; Scobie M; Helleday T
Editorial comment: ANNALS OF ONCOLOGY. 2017;28(9):2054-2055
Chemotherapy-induced toxicity-a secondary effect caused by released DNA?
Helleday T
Editorial comment: ANNALS OF ONCOLOGY. 2017;28(7):1407-1408
CHD1: a new treatment biomarker for recombination deficiency in castration resistant prostate cancer?
Helleday T
Corrigendum: NATURE. 2017;544(7651):508
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool (vol 508, pg 215, 2014)
Gad H; Koolmeister T; Jemth A-S; Eshtad S; Jacques SA; Strom CE; Svensson LM; Schultz N; Lundback T; Einarsdottir BO; Saleh A; Gokturk C; Baranczewski P; Svensson R; Berntsson RP-A; Gustafsson R; Stromberg K; Sanjiv K; Jacques-Cordonnier M-C; Desroses M; Gustavsson A-L; Olofsson R; Johansson F; Homan EJ; Loseva O; Brautigam L; Johansson L; Hoglund A; Hagenkort A; Pham T; Altun M; Gaugaz FZ; Vikingsson S; Evers B; Henriksson M; Vallin KSA; Wallner OA; Hammarstrom LGJ; Wiita E; Almlof I; Kalderen C; Axelsson H; Djureinovic T; Puigvert JC; Haggblad M; Jeppsson F; Martens U; Lundin C; Lundgren B; Granelli I; Jensen AJ; Artursson P; Nilsson JA; Stenmark P; Scobie M; Berglund UW; Helleday T
Meeting abstract: MOLECULAR CANCER RESEARCH. 2017;15:IA12
Poisoning cancer with oxidized nucleotides by targeting MTH1
Helleday T
Corrigendum: CELL REPORTS. 2016;17(12):3407-3416
Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities (vol 14, pg 298, 2016)
Sanjiv K; Hagenkort A; Calderon-Montano JM; Koolmeister T; Reaper PM; Mortusewicz O; Jacques SA; Kuiper RV; Schultz N; Scobie M; Charlton PA; Pollard JR; Berglund UW; Altun M; Helleday T
Meeting abstract: TOXICOLOGY LETTERS. 2016;258:S57
Introducing a new method for absolute quantification of DNA repair proteins in relation to drug development: LC-MS/MS with isotope dilution
Coskun E; Jaruga P; Jemth A; Loseva O; Leona SD; Tona A; Lowenthal MS; Reddy PT; Helleday T; Dizdaroglu M
Review: DNA REPAIR. 2016;44:193-204
Pathways controlling dNTP pools to maintain genome stability
Rudd SG; Valerie NCK; Helleday T
Meeting abstract: CANCER RESEARCH. 2016;76:1260
Polymerase kappa determines the sensitivity of MTH1 inhibitors to cisplatin-resistant cell
Sanjiv K; Gad H; Rudd S; Hurley R; Herr P; Montano JMC; Mortusewicz O; Koolmeister T; Jaques S; Moron EB; Hoglund A; Lee T-C; Scobie M; Kaufmann S; Weroha J; Berglund UW; Hendrickson AW; Helleday T
Meeting abstract: CANCER RESEARCH. 2016;76:lb-176-lb-176
The human androgen receptor regulates DNA damage response (DDR) in prostate cancer
Asim M; Zecchini H; Tarish F; Massie C; Baridi A; Warren A; Zhao W; McDuffus L-A; Mascalchi P; Shaw G; Dev H; Wadhwa K; Wijnhoven P; Forment J; Lyons S; Lynch A; O'Neill C; Zecchini V; Rennie P; Baniahmad A; Tavare S; Mills I; Schulz N; Galanty Y; Helleday T; Neal D
Editorial comment: SCIENCE. 2016;352(6290):1178-1179
Drugging DNA repair
Jackson SP; Helleday T
Editorial comment: ANNALS OF ONCOLOGY. 2016;27(5):755-757
PARP inhibitor receives FDA breakthrough therapy designation in castration resistant prostate cancer: beyond germline BRCA mutations
Helleday T
Corrigendum: MOLECULAR CELL. 2016;61(1):181
Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair (vol 60, pg 163, 2015)
Xie S; Mortusewicz O; Ma HT; Herr P; Poon RYC; Helleday T; Qian C
Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2016;566:305-332
Production, Purification, and Characterization of ¹⁵N-Labeled DNA Repair Proteins as Internal Standards for Mass Spectrometric Measurements
Reddy PT; Jaruga P; Nelson BC; Lowenthal MS; Jemth A-S; Loseva O; Coskun E; Helleday T; Dizdaroglu M
Review: FEBS JOURNAL. 2016;283(2):232-245
Targeting DNA repair, DNA metabolism and replication stress as anti-cancer strategies
Puigvert JC; Sanjiv K; Helleday T
Editorial comment: NEW ENGLAND JOURNAL OF MEDICINE. 2015;373(16):1570-1571
Poisoning Cancer Cells with Oxidized Nucleosides
Helleday T
Review: PROGRESS IN LIPID RESEARCH. 2015;58:51-75
Lysophosphatidic acid receptor (LPAR) modulators: The current pharmacological toolbox
Llona-Minguez S; Ghassemian A; Helleday T
Meeting abstract: ANNALS OF ONCOLOGY. 2015;26:9
MTH1 INHIBITORS IN CANCER TREATMENT
Helleday T
Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2014;50:81
The combination of Chk-1 and ATR inhibitor synergistically kills cancer cells
Sanjiv K; Hagenkort A; Reaper PM; Koolmeister T; Mortusewicz O; Schultz N; Scobie M; Berglund UW; Charlton PA; Pollard JR; Helleday T
Review: NATURE REVIEWS GENETICS. 2014;15(9):585-598
Mechanisms underlying mutational signatures in human cancers
Helleday T; Eshtad S; Nik-Zainal S
Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2014;50:s87
The interplay between the redox environment, MTH1 and cancer
Braeutigam L; Fiskesund R; Warpman-Berglund U; Helleday T
Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2014;50:S3
Targeting MTH1 prevents sanitation of oxidised dNTP pools and causes cancer-selective DNA damage and cell death
Helleday T
Editorial comment: ANNALS OF ONCOLOGY. 2014;25(7):1253-1255
Cancer phenotypic lethality, exemplified by the non-essential MTH1 enzyme being required for cancer survival
Helleday T
Review: EXPERT REVIEWS IN MOLECULAR MEDICINE. 2014;16:e10
Chemical strategies for development of ATR inhibitors
Llona-Minguez S; Hoglund A; Jacques SA; Koolmeister T; Helleday T
Corrigendum: MOLECULAR CELL. 2014;53(1):162-163
miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors (vol 41, pg 210, 2011)
Moskwa P; Buffa FM; Pan Y; Panchakshari R; Gottipati P; Muschel RJ; Beech J; Kulshrestha R; Abdelmohsen K; Weinstock DM; Gorospe M; Harris AL; Helleday T; Chowdhury D
Editorial comment: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2013;20(12):1348-1350
PrimPol breaks replication barriers
Helleday T
Meeting abstract: MOLECULAR CANCER THERAPEUTICS. 2013;12(11):cn05-04-cn05-04
Novel DNA repair targets for anticancer treatments
Helleday T
Review: CURRENT OPINION IN ONCOLOGY. 2013;25(6):609-614
Putting poly (ADP-ribose) polymerase and other DNA repair inhibitors into clinical practice
Helleday T
Corrigendum: NATURE. 2013;500(7463):490
Replication stress links structural and numerical cancer chromosomal instability (vol 494, pg 492, 2013)
Burrell RA; McClelland SE; Endesfelder D; Groth P; Weller M-C; Shaikh N; Domingo E; Kanu N; Dewhurst SM; Gronroos E; Chew SK; Rowan AJ; Schenk A; Sheffer M; Howell M; Kschischo M; Behrens A; Helleday T; Bartek J; Tomlinson IP; Swanton C
Editorial comment: EMBO JOURNAL. 2013;32(4):493-495
Early replication fragile sites: where replication-transcription collisions cause genetic instability
Mortusewicz O; Herr P; Helleday T
Corrigendum: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(41):34494
PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA (vol 52, pg 3108, 2009)
Loseva O; Jemth A-S; Bryant HE; Schueler H; Lehtioe L; Karlberg T; Helleday T
Corrigendum: NUCLEIC ACIDS RESEARCH. 2012;40(12):5794
Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks (vol 33, pg 3799, 2005)
Lundin C; North M; Erixon K; Walters K; Jenssen D; Goldman ASH; Helleday T
Meeting abstract: TOXICOLOGY LETTERS. 2012;211:S9
DNA repair pathways as target for cancer therapy
Helleday T
Review: CURRENT MOLECULAR PHARMACOLOGY. 2012;5(1):54-67
Biological relevance of DNA polymerase β and translesion synthesis polymerases to cancer and its treatment.
Nicolay NH; Helleday T; Sharma RA
Editorial comment: RADIATION RESEARCH. 2011;176(3):412-414
New Translational Possibilities for Microenvironmental Modulation of Radiosensitivity
Glazer PM; Quynh-Thu L; Bristow R; Helleday T; Pelroy R; Bernhard EJ
Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2011;47:S58
PARP Inhibitors Sensitivity and Resistance
Helleday T
Review: MOLECULAR ONCOLOGY. 2011;5(4):387-393
The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings
Helleday T
Meeting abstract: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2010;8(7):106
POLQ (DNA polyermase theta) as a novel therapeutic target: preclinical and clinical data
Higgins GS; Prevo R; Lundin C; Helleday T; Buffa FM; Harris AL; Muschel RJ; Bernhard EJ; Hickson ID; McKenna WG
Review: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2010;11(10):683-687
Pathways of mammalian replication fork restart
Petermann E; Helleday T
Meeting abstract: CHEMISTRY AND PHYSICS OF LIPIDS. 2010;163:s36
Anti-proliferative effects of taurine conjugated fatty acids
Chatzakos V; Slatis K; Djureinovic T; Helleday T; Hunt MC
Review: TRENDS IN PHARMACOLOGICAL SCIENCES. 2010;31(8):372-380
Targeting homologous recombination repair defects in cancer
Evers B; Helleday T; Jonkers J
Meeting abstract: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2010;8(5):156
Homologous recombination in cancer development, treatment and development of drug resistance
Helleday T
Corrigendum: CANCER RESEARCH. 2010;70(9):3853
A Small Interfering RNA Screen of Genes Involved in DNA Repair Identifies Tumor-Specific Radiosensitization by POLQ Knockdown
Higgins GS; Prevo R; Lee Y-F; Helleday T; Muschel RJ; Taylor S; Yoshimura M; Hickson ID; Bernhard EJ; McKenna WG
Meeting abstract: CANCER RESEARCH. 2010;70:3932
Loss of PTEN sensitizes cells to DNA damaging agents in a RAD51-independent manner
Fraser ME; Zhao H; Lundin C; Evans A; Helleday T; Bristow RG
Editorial comment: CURRENT BIOLOGY. 2010;20(2):R57-R58
Mutagenesis: Mutating a Gene While Reading It
Helleday T
Meeting abstract: BREAST CANCER RESEARCH. 2010;12:p52
Radiotherapy fraction size sensitivity is modulated by DNA repair systems
Somaiah N; Yarnold J; Daley F; Pearson A; Rothkamm K; Helleday T
Meeting abstract: MOLECULAR CANCER THERAPEUTICS. 2009;8(12):a115
Contextual synthetic lethality: Repair-deficient hypoxic tumor cells are sensitized to poly(ADP-ribose) polymerase (PARP) inhibition
Chan N; Fires IM; Bencokova Z; Coackley C; Bhogal N; Lakshman M; Gottipati P; Oliver FJ; Helleday T; Hammond EM; Bristow RG
Meeting abstract: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2009;7(2):39
Exploiting cancer defects in targeted therapy
Helleday T
Meeting abstract: CHEMISTRY AND PHYSICS OF LIPIDS. 2009;160:s23
Anti-proliferative effects of glycine conjugated fatty acids
Chatzakos V; Djureinovic T; Helleday T; Hunt M
Published conference paper: BIOCHEMICAL SOCIETY TRANSACTIONS. 2009;37(Pt 3):605-613
PCNA on the crossroad of cancer
Stolimenov I; Helleday T
Review: MUTAGENESIS. 2009;24(3):203-210
Transcription-associated recombination in eukaryotes: link between transcription, replication and recombination
Gottipati P; Helleday T
Review: EUROPEAN JOURNAL OF CANCER. 2008;44(7):921-927
Amplifying tumour-specific replication lesions by DNA repair inhibitors - A new era in targeted cancer therapy
Helleday T
Review: NATURE REVIEWS CANCER. 2008;8(3):193-204
DNA repair pathways as targets for cancer therapy
Helleday T; Petermann E; Lundin C; Hodgson B; Sharma RA
Published conference paper: BIOCHEMICAL SOCIETY TRANSACTIONS. 2007;35(Pt 5):1352-1354
DNA replication-associated lesions: importance in early tumorigenesis and cancer therapy
Petermann E; Helleday T
Meeting abstract: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2007;5(4):33
DNA replication repair: molecular insights towards new approaches to targeted anti-cancer therapy
Helleday T
Review: DNA REPAIR. 2007;6(7):923-935
DNA double-strand break repair: From mechanistic understanding to cancer treatment
Helleday T; Lo J; van Gent DC; Engelward BP
Corrigendum: NATURE. 2007;447(7142):346
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase (vol 434, pg 913, 2005)
Bryant HE; Schultz N; Thomas HD; Parker KM; Flower D; Lopez E; Kyle S; Meuth M; Curtin NJ; Helleday T
Review: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2003;532(1-2):103-115
Pathways for mitotic homologous recombination in mammalian cells
Helleday T
Published conference paper: ATLA-ALTERNATIVES TO LABORATORY ANIMALS. 2001;29(3):233-241
The DRAG test: an assay for detection of genotoxic damage
Helleday T; Johansson F; Jenssen D
Published conference paper: TOXICOLOGY IN VITRO. 1998;12(5):519-522
Session 1: Signal transduction
Helleday T
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Professor, Onkologi-Patologi, Karolinska Institutet, 2018-

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Docent, Stockholm University

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Johan Boström, Studying the Cell Cycle using Systems Biology and High Content Characterization of the Ubiquitin Proteasome System., https://openarchive.ki.se/xmlui/handle/10616/47323, 2014
Saeed Eshtad, Targeting DNA repair Pathways for Cancer Therapy., https://openarchive.ki.se/xmlui/handle/10616/45467, 2012

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