Thomas Helleday

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About me

Thomas Helleday is a Professor of Chemical Biology. In his research, he is focusing on exploiting the weaknesses of cancer cells in DNA repair and altered metabolism. His research group uses genetic tools and develops probes to study identified target proteins more closely. By selectively inhibiting DNA repair or proteins that are crucial for the growth of cancer cells, the researchers tailor new treatment methods against cancer.

Articles

Article: NATURE COMMUNICATIONS. 2025;16(1):1741
Virtual fragment screening for DNA repair inhibitors in vast chemical space
Luttens A; Vo DD; Scaletti ER; Wiita E; Almlof I; Wallner O; Davies J; Kosenina S; Meng L; Long M; Mortusewicz O; Masuyer G; Ballante F; Michel M; Homan E; Scobie M; Kalderen C; Berglund UW; Tarnovskiy AV; Radchenko DS; Moroz YS; Kihlberg J; Stenmark P; Helleday T; Carlsson J
Article: NATURE COMMUNICATIONS. 2024;15(1):10347
Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM
Valerie NCK; Sanjiv K; Mortusewicz O; Zhang SM; Alam S; Pires MJ; Stigsdotter H; Rasti A; Langelier M-F; Rehling D; Throup A; Purewal-Sidhu O; Desroses M; Onireti J; Wakchaure P; Almloef I; Bostrom J; Bevc L; Benzi G; Stenmark P; Pascal JM; Helleday T; Page BDG; Altun M
Article: FEBS JOURNAL. 2024;291(19):4301-4322
Kinetic and structural characterization of NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis
Scaletti ER; Unterlass JE; Almlof I; Koolmeister T; Vallin KS; Kapsitidou D; Tsuber V; Helleday T; Stenmark P; Jemth A-S
Article: MOLECULAR ONCOLOGY. 2024;18(9):2179-2195
The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation
Marttila P; Bonagas N; Chalkiadaki C; Stigsdotter H; Schelzig K; Shen J; Farhat CM; Hondema A; Albers J; Wiita E; Rasti A; Warpman Berglund U; Slipicevic A; Mortusewicz O; Helleday T
Article: ONCOGENESIS. 2024;13(1):17
Mitotic MTH1 inhibitor TH1579 induces PD-L1 expression and inflammatory response through the cGAS-STING pathway
Shen J; Mancina EG; Chen S; Manolakou T; Gad H; Berglund UW; Sanjiv K; Helleday T
Article: NATURE COMMUNICATIONS. 2024;15(1):3475
High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue
Zhang N; Harbers L; Simonetti M; Diekmann C; Verron Q; Berrino E; Bellomo SE; Longo GMC; Ratz M; Schultz N; Tarish F; Su P; Han B; Wang W; Onorato S; Grassini D; Ballarino R; Giordano S; Yang Q; Sapino A; Frisen J; Alkass K; Druid H; Roukos V; Helleday T; Marchio C; Bienko M; Crosetto N
Article: CELL DEATH & DISEASE. 2024;15(2):150
Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence
Fabbrizi MR; Nickson CM; Hughes JR; Robinson EA; Vaidya K; Rubbi CP; Kacperek A; Bryant HE; Helleday T; Parsons JL
Article: ISCIENCE. 2024;27(2):108907
Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel
Zhang SM; Paulin CBJ; Shu H; Yagu-Capilla M; Michel M; Marttila P; Ortis F; Bwanika HC; Dirks C; Venkatram RP; Wiita E; Jemth A-S; Almlof I; Loseva O; Hormann FM; Koolmeister T; Linde E; Lee S; Llona-Minguez S; Haraldsson M; Axelsson H; Stromberg K; Homan EJ; Scobie M; Lundback T; Helleday T; Rudd SG
Article: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2023;26(29)
Synthesis of Substituted Indazole Acetic Acids by N-N Bond Forming Reactions
Odell LR; Skillinghaug B; Matt C; Wu P; Koolmeister T; Desroses M; Llona-Minguez S; Wallner O; Helleday T; Scobie M
Article: BLOOD. 2023;141(26):3166-3183
Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL
Largeot A; Klapp V; Viry E; Gonder S; Botana IF; Blomme A; Benzarti M; Pierson S; Duculty C; Marttila P; Wierz M; Gargiulo E; Pagano G; An N; El Hachem N; Hernandez DP; Chakraborty S; Ysebaert L; Francois J-H; Clemente SC; Berchem G; Efremov DG; Dittmar G; Szpakowska M; Chevigne A; Nazarov PV; Helleday T; Close P; Meiser J; Stamatopoulos B; Desaubry L; Paggetti J; Moussay E
Article: ONCOGENE. 2023;42(16):1282-1293
NUDT22 promotes cancer growth through pyrimidine salvage
Walter M; Mayr F; Hanna BMF; Cookson V; Mortusewicz O; Helleday T; Herr P
Article: NATURE METABOLISM. 2023;5(4):642-659
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells
Green AC; Marttila P; Kiweler N; Chalkiadaki C; Wiita E; Cookson V; Lesur A; Eiden K; Bernardin F; Vallin KSA; Borhade S; Long M; Ghahe EK; Jimenez-Alonso JJ; Jemth A-S; Loseva O; Mortusewicz O; Meyers M; Viry E; Johansson AI; Hodek O; Homan E; Bonagas N; Ramos L; Sandberg L; Frodin M; Moussay E; Slipicevic A; Letellier E; Paggetti J; Sorensen CS; Helleday T; Henriksson M; Meiser J
Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2023;21(1):169
Short term starvation potentiates the efficacy of chemotherapy in triple negative breast cancer via metabolic reprogramming
Pateras IS; Williams C; Gianniou DD; Margetis AT; Avgeris M; Rousakis P; Legaki A-I; Mirtschink P; Zhang W; Panoutsopoulou K; Delis AD; Pagakis SN; Tang W; Ambs S; Berglund UW; Helleday T; Varvarigou A; Chatzigeorgiou A; Nordstrom A; Tsitsilonis OE; Trougakos IP; Gilthorpe JD; Frisan T
Article: NATURE COMMUNICATIONS. 2023;14(1):643
Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model
Tanner L; Single AB; Bhongir RKV; Heusel M; Mohanty T; Karlsson CAQ; Pan L; Clausson C-M; Bergwik J; Wang K; Andersson CK; Oommen RM; Erjefalt JS; Malmstrom J; Wallner O; Boldogh I; Helleday T; Kalderen C; Egesten A
Article: CHEMMEDCHEM. 2023;18(1):e202200310
Optimization of N-Piperidinyl-Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8-Oxo-Guanine DNA Glycosylase 1
Wallner O; Cazares-Korner A; Scaletti ER; Masuyer G; Bekkhus T; Visnes T; Mamonov K; Ortis F; Lundback T; Volkova M; Koolmeister T; Wiita E; Loseva O; Pandey M; Homan E; Benitez-Buelga C; Davies J; Scobie M; Berglund UW; Kalderen C; Stenmark P; Helleday T; Michel M
Article: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. 2023;37:3946320231158025
Infiltrating immune cells in prostate cancer tissue after androgen deprivation and radiotherapy
Erlandsson A; Lundholm M; Watz J; Bergh A; Petrova E; Alamdari F; Helleday T; Davidsson S; Andren O; Tarish F
Article: CANCER TREATMENT AND RESEARCH. 2023;186:223-237
Mitotic MTH1 Inhibitors in Treatment of Cancer.
Helleday T
Article: CELLS. 2022;11(24):4121
An Approach for Systems-Level Understanding of Prostate Cancer from High-Throughput Data Integration to Pathway Modeling and Simulation
Mobashir M; Turunen SP; Izhari MA; Ashankyty IM; Helleday T; Lehti K
Article: BIOMOLECULES. 2022;12(12):1777
Overexpressed c-Myc Sensitizes Cells to TH1579, a Mitotic Arrest and Oxidative DNA Damage Inducer
Henriksson S; Calderon-Montano JM; Solvie D; Berglund UW; Helleday T
Article: JOURNAL OF HEPATOLOGY. 2022;77(5):1311-1324
NUDT1 promotes the accumulation and longevity of CD103⁺ T_RM cells in primary biliary cholangitis
Huang B; Lyu Z; Qian Q; Chen Y; Zhang J; Li B; Li Y; Liang J; Liu Q; Li Y; Chen R; Lian M; Xiao X; Miao Q; Wang Q; Fang J; Lian Z; Li Y; Tang R; Helleday T; Gershwin ME; You Z; Ma X
Article: NATURE COMMUNICATIONS. 2022;13(1):5475
Spatio-temporal analysis of prostate tumors in situ suggests pre-existence of treatment-resistant clones
Marklund M; Schultz N; Friedrich S; Berglund E; Tarish F; Tanoglidi A; Liu Y; Bergenstrahle L; Erickson A; Helleday T; Lamb AD; Sonnhammer E; Lundeberg J
Article: CHEMMEDCHEM. 2022;17(18):e202200274
The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform-Selective Inhibitors
Scaletti ER; Gustafsson Westergren R; Andersson Y; Wiita E; Henriksson M; Homan EJ; Jemth A-S; Helleday T; Stenmark P
Article: NATURE. 2022;608(7922):360-367
Spatially resolved clonal copy number alterations in benign and malignant tissue
Erickson A; He M; Berglund E; Marklund M; Mirzazadeh R; Schultz N; Kvastad L; Andersson A; Bergenstrahle L; Bergenstrahle J; Larsson L; Galicia LA; Shamikh A; Basmaci E; De Stahl TD; Rajakumar T; Doultsinos D; Thrane K; Ji AL; Khavari PA; Tarish F; Tanoglidi A; Maaskola J; Colling R; Mirtti T; Hamdy FC; Woodcock DJ; Helleday T; Mills IG; Lamb AD; Lundeberg J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2022;298(8):102169
Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir
Jemth A-S; Scaletti ER; Homan E; Stenmark P; Helleday T; Michel M
Article: SCIENCE. 2022;376(6600):1471-1476
Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.
Michel M; Benítez-Buelga C; Calvo PA; Hanna BMF; Mortusewicz O; Masuyer G; Davies J; Wallner O; Sanjiv K; Albers JJ; Castañeda-Zegarra S; Jemth A-S; Visnes T; Sastre-Perona A; Danda AN; Homan EJ; Marimuthu K; Zhenjun Z; Chi CN; Sarno A; Wiita E; von Nicolai C; Komor AJ; Rajagopal V; Müller S; Hank EC; Varga M; Scaletti ER; Pandey M; Karsten S; Haslene-Hox H; Loevenich S; Marttila P; Rasti A; Mamonov K; Ortis F; Schömberg F; Loseva O; Stewart J; D'Arcy-Evans N; Koolmeister T; Henriksson M; Michel D; de Ory A; Acero L; Calvete O; Scobie M; Hertweck C; Vilotijevic I; Kalderén C; Osorio A; Perona R; Stolz A; Stenmark P; Berglund UW; de Vega M; Helleday T
Article: FRONTIERS IN ONCOLOGY. 2022;12:888810
OGG1 Inhibition Triggers Synthetic Lethality and Enhances The Effect of PARP Inhibitor Olaparib in BRCA1-Deficient TNBC Cells
Baquero JM; Marchena-Perea E; Mirabet R; Torres-Ruiz R; Blanco-Aparicio C; Rodriguez-Perales S; Helleday T; Benitez-Buelga C; Benitez J; Osorio A
Article: MOLECULAR CANCER THERAPEUTICS. 2022;21(5):703-714
Inhibition of Oxidized Nucleotide Sanitation By TH1579 and Conventional Chemotherapy Cooperatively Enhance Oxidative DNA Damage and Survival in AML
Centio A; Estruch M; Reckzeh K; Sanjiv K; Vittori C; Engelhard S; Berglund UW; Helleday T; Theilgaard-Monch K
Article: HEPATOLOGY COMMUNICATIONS. 2022;6(5):1016-1031
MutT Homolog 1 Inhibitor Karonudib Attenuates Autoimmune Hepatitis by Inhibiting DNA Repair in Activated T Cells
Chen Y; Hua X; Huang B; Karsten S; You Z; Li B; Li Y; Li Y; Liang J; Zhang J; Wei Y; Chen R; Lyu Z; Xiao X; Lian M; Wei J; Fang J; Miao Q; Wang Q; Berglung UW; Tang R; Helleday T; Ma X
Article: NATURE CANCER. 2022;3(2):156-172
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
Bonagas N; Gustafsson NMS; Henriksson M; Marttila P; Gustafsson R; Wiita E; Borhade S; Green AC; Vallin KSA; Sarno A; Svensson R; Gokturk C; Pham T; Jemth A-S; Loseva O; Cookson V; Kiweler N; Sandberg L; Rasti A; Unterlass JE; Haraldsson M; Andersson Y; Scaletti ER; Bengtsson C; Paulin CBJ; Sanjiv K; Abdurakhmanov E; Pudelko L; Kunz B; Desroses M; Iliev P; Farnegardh K; Kramer A; Garg N; Michel M; Haggblad S; Jarvius M; Kalderen C; Jensen AB; Almlof I; Karsten S; Zhang SM; Haggblad M; Eriksson A; Liu J; Glinghammar B; Nekhotiaeva N; Klingegard F; Koolmeister T; Martens U; Llona-Minguez S; Moulson R; Nordstrom H; Parrow V; Dahllund L; Sjoberg B; Vargas IL; Vo DD; Wannberg J; Knapp S; Krokan HE; Arvidsson PI; Scobie M; Meiser J; Stenmark P; Berglund UW; Homan EJ; Helleday T
Article: FRONTIERS IN PHARMACOLOGY. 2022;13:999180
Pharmacological OGG1 inhibition decreases murine allergic airway inflammation
Tanner L; Bergwik J; Bhongir RKV; Pan L; Dong C; Wallner O; Kalderen C; Helleday T; Boldogh I; Adner M; Egesten A
Article: CELL DEATH AND DIFFERENTIATION. 2022;29(1):246-261
MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells.
Karsten S; Fiskesund R; Zhang X-M; Marttila P; Sanjiv K; Pham T; Rasti A; Bräutigam L; Almlöf I; Marcusson-Ståhl M; Sandman C; Platzack B; Harris RA; Kalderén C; Cederbrant K; Helleday T; Warpman Berglund U
Article: CELL CHEMICAL BIOLOGY. 2021;28(12):1693-1702.e6
NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir
Zhang SM; Rehling D; Jemth A-S; Throup A; Landazuri N; Almlof I; Gottmann M; Valerie NCK; Borhade SR; Wakchaure P; Page BDG; Desroses M; Homan EJ; Scobie M; Rudd SG; Berglund UW; Soderberg-Naucler C; Stenmark P; Helleday T
Article: CANCER RESEARCH. 2021;81(22):5733-5744
MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia
Sanjiv K; Calderon-Montano JM; Pham TM; Erkers T; Tsuber V; Almlof I; Hoglund A; Heshmati Y; Seashore-Ludlow B; Danda AN; Gad H; Wiita E; Gokturk C; Rasti A; Friedrich S; Centio A; Estruch M; Vatsveen TK; Struyf N; Visnes T; Scobie M; Koolmeister T; Henriksson M; Wallner O; Sandvall T; Lehmann S; Theilgaard-Monch K; Garnett MJ; Ostling P; Walfridsson J; Helleday T; Berglund UW
Article: CELLS. 2021;10(11):3040
Adaptation to Chronic-Cycling Hypoxia Renders Cancer Cells Resistant to MTH1-Inhibitor Treatment Which Can Be Counteracted by Glutathione Depletion
Hansel C; Hlouschek J; Xiang K; Melnikova M; Thomale J; Helleday T; Jendrossek V; Matschke J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(36):e2007898118
Defects in 8-oxo-guanine repair pathway cause high frequency of C > A substitutions in neuroblastoma
van den Boogaard ML; Oka R; Hakkert A; Schild L; Ebus ME; van Gerven MR; Zwijnenburg DA; Molenaar P; Hoyng LL; Dolman MEM; Essing AHW; Koopmans B; Helleday T; Drost J; van Boxtel R; Versteeg R; Koster J; Molenaar JJ
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2021;141(8):2037-2048.e4
MTH1 Inhibitors for the Treatment of Psoriasis
Eding CB; Kohler I; Verma D; Sjogren F; Bamberg C; Karsten S; Pham T; Scobie M; Helleday T; Berglund UW; Enerback C
Article: CANCER RESEARCH. 2021;81(15):4079-4093
NEIL3 Prevents Senescence in Hepatocellular Carcinoma by Repairing Oxidative Lesions at Telomeres during Mitosis
Zhao Z; Gad H; Benitez-Buelga C; Sanjiv K; Hua X; Kang H; Feng M; Zhao Z; Berglund UW; Xia Q; Helleday T
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(9):4542
NEIL1 and NEIL2 Are Recruited as Potential Backup for OGG1 upon OGG1 Depletion or Inhibition by TH5487
Hanna BMF; Michel M; Helleday T; Mortusewicz O
Article: SCIENTIFIC REPORTS. 2021;11(1):6317
Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma
Oksvold MP; Berglund UW; Gad H; Bai B; Stokke T; Rein ID; Pham T; Sanjiv K; Oy GF; Norum JH; Smeland EB; Myklebust JH; Helleday T; Vatsveen TK
Article: SCIENTIFIC REPORTS. 2021;11(1):3490
Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects
Miguel Baquero J; Benitez-Buelga C; Rajagopal V; Zhao Z; Torres-Ruiz R; Mueller S; Hanna BMF; Loseva O; Wallner O; Michel M; Rodriguez-Perales S; Gad H; Visnes T; Helleday T; Benitez J; Osorio A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2021;296:100568
Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity
Rehling D; Zhang SM; Jemth A-S; Koolmeister T; Throup A; Wallner O; Scaletti E; Moriyama T; Nishii R; Davies J; Desroses M; Rudd SG; Scobie M; Homan E; Berglund UW; Yang JJ; Helleday T; Stenmark P
Article: VIRUSES-BASEL. 2020;13(1):E37-37
Broadly Active Antiviral Compounds Disturb Zika Virus Progeny Release Rescuing Virus-Induced Toxicity in Brain Organoids
Pettke A; Tampere M; Pronk R; Wallner O; Falk A; Warpman Berglund U; Helleday T; Mirazimi A; Puumalainen M-R
Article: VIRUSES-BASEL. 2020;12(12):E1423-1423
Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses
Tampere M; Pettke A; Salata C; Wallner O; Koolmeister T; Cazares-Korner A; Visnes T; Hesselman MC; Kunold E; Wiita E; Kalderen C; Lightowler M; Jemth A-S; Lehtio J; Rosenquist A; Warpman-Berglund U; Helleday T; Mirazimi A; Jafari R; Puumalainen M-R
Article: NUCLEIC ACIDS RESEARCH. 2020;48(21):12234-12251
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress
Visnes T; Benitez-Buelga C; Cazares-Korner A; Sanjiv K; Hanna BMF; Mortusewicz O; Rajagopal V; Albers JJ; Hagey DW; Bekkhus T; Eshtad S; Baquero JM; Masuyer G; Wallner O; Muller S; Pham T; Gokturk C; Rasti A; Suman S; Torres-Ruiz R; Sarno A; Wiita E; Homan EJ; Karsten S; Marimuthu K; Michel M; Koolmeister T; Scobie M; Loseva O; Almlof I; Unterlass JE; Pettke A; Bostrom J; Pandey M; Gad H; Herr P; Jemth A-S; El Andaloussi S; Kalderen C; Rodriguez-Perales S; Benitez J; Krokan HE; Altun M; Stenmark P; Berglund UW; Helleday T
Article: BIOMOLECULES. 2020;10(11):E1483-1483
OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions
Hanna BMF; Helleday T; Mortusewicz O
Article: NATURE CHEMICAL BIOLOGY. 2020;16(10):1120-1128
Development of a chemical probe against NUDT15
Zhang SM; Desroses M; Hagenkort A; Valerie NCK; Rehling D; Carter M; Wallner O; Koolmeister T; Throup A; Jemth A-S; Almlof I; Loseva O; Lundback T; Axelsson H; Regmi S; Sarno A; Kraemer A; Pudelko L; Brautigam L; Rasti A; Gottmann M; Wiita E; Kutzner J; Schaller T; Kalderen C; Cazares-Korner A; Page BDG; Krimpenfort R; Eshtad S; Altun M; Rudd SG; Knapp S; Scobie M; Homan EJ; Berglund UW; Stenmark P; Helleday T
Article: NEOPLASIA. 2020;22(9):390-398
Ex vivo assessment of targeted therapies in a rare metastatic epithelial-myoepithelial carcinoma
Makela R; Arjonen A; Rahmanto AS; Harma V; Lehtio J; Kuopio T; Helleday T; Sangfelt O; Kononen J; Rantala JK
Article: CANCER RESEARCH. 2020;80(17):3530-3541
MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG
Rudd SG; Gad H; Sanjiv K; Amaral N; Hagenkort A; Groth P; Strom CE; Mortusewicz O; Berglund UW; Helleday T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2020;295(33):11656-11668
Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target
Skerlova J; Unterlass J; Gottmann M; Marttila P; Homan E; Helleday T; Jemth A-S; Stenmark P
Article: CELL DEATH AND DIFFERENTIATION. 2020;27(7):2081-2098
AXL and CAV-1 play a role for MTH1 inhibitor TH1579 sensitivity in cutaneous malignant melanoma
Das I; Gad H; Braeutigam L; Pudelko L; Tuominen R; Hoiom V; Almlof I; Rajagopal V; Hansson J; Helleday T; Brage SE; Berglund UW
Article: ORPHANET JOURNAL OF RARE DISEASES. 2020;15(1):170
High content drug screening for Fanconi anemia therapeutics
Montanuy H; Camps-Fajol C; Carreras-Puigvert J; Haggblad M; Lundgren B; Aza-Carmona M; Helleday T; Minguillon J; Surralles J
Article: CLINICAL CANCER RESEARCH. 2020;26(12):3044-3057
Gefitinib and Afatinib Show Potential Efficacy for Fanconi Anemia-Related Head and Neck Cancer
Montanuy H; Martinez-Barriocanal A; Antonio Casado J; Rovirosa L; Jose Ramirez M; Nieto R; Carrascoso-Rubio C; Riera P; Gonzalez A; Lerma E; Lasa A; Carreras-Puigvert J; Helleday T; Bueren JA; Arango D; Minguillon J; Surralles J
Article: BMC MEDICAL GENOMICS. 2020;13(1):76
MetaCNV-a consensus approach to infer accurate copy numbers from low coverage data
Friedrich S; Barbulescu R; Helleday T; Sonnhammer ELL
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2020;295(15):4761-4772
MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool
Scaletti ER; Vallin KS; Brautigam L; Sarno A; Berglund UW; Helleday T; Stenmark P; Jemth A-S
Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(4):608-623
Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics
Herr P; Bostrom J; Rullman E; Rudd SG; Vesterlund M; Lehtio J; Helleday T; Maddalo G; Altun M
Article: CANCER RESEARCH. 2020;80(7):1538-1550
Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds
Peuget S; Zhu J; Sanz G; Singh M; Gaetani M; Chen X; Shi Y; Saei AA; Visnes T; Lindstrom MS; Rihani A; Moyano-Galceran L; Carlson JW; Hjerpe E; Joneborg U; Lehti K; Hartman J; Helleday T; Zubarev R; Selivanova G
Article: EMBO MOLECULAR MEDICINE. 2020;12(3):e10419
Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy
Rudd SG; Tsesmetzis N; Sanjiv K; Paulin CBJ; Sandhow L; Kutzner J; Myrberg IH; Bunten SS; Axelsson H; Zhang SM; Rasti A; Makela P; Coggins SA; Tao S; Suman S; Branca RM; Mermelekas G; Wiita E; Lee S; Walfridsson J; Schinazi RF; Kim B; Lehtio J; Rassidakis GZ; Tamm KP; Warpman-Berglund U; Heyman M; Grander D; Lehmann S; Lundback T; Qian H; Henter J-I; Schaller T; Helleday T; Herold N
Article: EBIOMEDICINE. 2020;53:102704
TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model
Moukengue B; Brown HK; Charrier C; Battaglia S; Baud'huin M; Quillard T; Pham TM; Pateras IS; Gorgoulis VG; Helleday T; Heymann D; Berglund UW; Ory B; Lamoureux F
Article: JOURNAL OF MOLECULAR BIOLOGY. 2020;432(4):1126-1142
The First Structure of an Active Mammalian dCTPase and its Complexes With Substrate Analogs and Products
Scaletti E; Claesson M; Helleday T; Jemth A-S; Stenmark P
Article: CELL DEATH AND DIFFERENTIATION. 2020;27(2):773-789
The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity
Espinoza JA; Zisi A; Kanellis DC; Carreras-Puigvert J; Henriksson M; Huhn D; Watanabe K; Helleday T; Lindstrom MS; Bartek J
Article: FRONTIERS IN CHEMISTRY. 2020;8:443
In silicoDruggability Assessment of the NUDIX Hydrolase Protein Family as a Workflow for Target Prioritization
Michel M; Homan EJ; Wiita E; Pedersen K; Almlof I; Gustavsson A-L; Lundback T; Helleday T; Berglund UW
Article: NUCLEIC ACIDS RESEARCH. 2019;47(14):7418-7429
Restriction of AID activity and somatic hypermutation by PARP-1
Tepper S; Mortusewicz O; Czlonka E; Bello A; Schmidt A; Jeschke J; Fischbach A; Pfeil I; Petersen-Mahrt SK; Mangerich A; Helleday T; Leonhardt H; Jungnickel B
Article: ACS OMEGA. 2019;4(7):11642-11656
Computational and Experimental Druggability Assessment of Human DNA Glycosylases
Michel M; Visnes T; Homan EJ; Seashore-Ludlow B; Hedenstrom M; Wiita E; Vallin K; Paulin CBJ; Zhang J; Wallner O; Scobie M; Schmidt A; Jenmalm-Jensen A; Berglund UW; Helleday T
Article: FEBS LETTERS. 2019;593(14):1863-1873
Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs
Scaletti E; Jemth A-S; Helleday T; Stenmark P
Article: BIOCHEMISTRY. 2019;58(7):887-899
Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana
Jemth A-S; Scaletti E; Carter M; Helleday T; Stenmark P
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2019;176(3):436-450
Ex vivo culture of cells derived from circulating tumour cell xenograft to support small cell lung cancer research and experimental therapeutics
Lallo A; Gulati S; Schenk MW; Khandelwal G; Berglund UW; Pateras IS; Chester CPE; Pham TM; Kalderen C; Frese KK; Gorgoulis VG; Miller C; Blackhall F; Helleday T; Dive C
Article: THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY. 2019;11:1758835919866960
Karonudib is a promising anticancer therapy in hepatocellular carcinoma
Hua X; Sanjiv K; Gad H; Pham T; Gokturk C; Rasti A; Zhao Z; He K; Feng M; Zang Y; Zhang J; Xia Q; Helleday T; Berglund UW
Article: NUCLEIC ACIDS RESEARCH. 2018;46(20):10888-10904
MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP
Jemth A-S; Gustafsson R; Brautigam L; Henriksson L; Vallin KSA; Sarno A; Almlof I; Homan E; Rasti A; Berglund UW; Stenmark P; Helleday T
Article: SCIENCE. 2018;362(6416):834-839
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation
Visnes T; Cazares-Korner A; Hao W; Wallner O; Masuyer G; Loseva O; Mortusewicz O; Wiita E; Sarno A; Manoilov A; Astorga-Wells J; Jemth A-S; Pan L; Sanjiv K; Karsten S; Gokturk C; Grube M; Homan EJ; Hanna BMF; Paulin CBJ; Pham T; Rasti A; Berglund UW; von Nicolai C; Benitez-Buelga C; Koolmeister T; Ivanic D; Iliev P; Scobie M; Krokan HE; Baranczewski P; Artursson P; Altun M; Jensen AJ; Kalderen C; Ba X; Zubarev RA; Stenmark P; Boldogh I; Helleday T
Article: DNA REPAIR. 2018;71:118-126
Targeting BER enzymes in cancer therapy
Visnes T; Grube M; Hanna BMF; Benitez-Buelga C; Cazares-Korner A; Helleday T
Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2018;160:80-88
STAT3 differential scanning fluorimetry and differential scanning light scattering assays: Addressing a missing link in the characterization of STAT3 inhibitor interactions
Desroses M; Busker S; Astorga-Wells J; Attarha S; Kolosenko I; Zubarev RA; Helleday T; Grander D; Page BDG
Article: ONCOTARGET. 2018;9(80):35069-35084
The Cockayne syndrome protein B is involved in the repair of 5-AZA-2'-deoxycytidine-induced DNA lesions.
Burgos-Morón E; Calderón-Montaño JM; Pastor N; Höglund A; Ruiz-Castizo Á; Domínguez I; López-Lázaro M; Hajji N; Helleday T; Mateos S; Orta ML
Article: NEURO-ONCOLOGY. 2018;20(11):1475-1484
An orthotopic glioblastoma animal model suitable for high-throughput screenings
Pudelko L; Edwards S; Balan M; Nyqvist D; Al-Saadi J; Dittmer J; Almlof I; Helleday T; Brautigam L
Article: NATURE COMMUNICATIONS. 2018;9(1):3872
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination
Gustafsson NMS; Farnegardh K; Bonagas N; Ninou AH; Groth P; Wiita E; Jonsson M; Hallberg K; Lehto J; Pennisi R; Martinsson J; Norstrom C; Hollers J; Schultz J; Andersson M; Markova N; Marttila P; Kim B; Norin M; Olin T; Helleday T
Article: HUMAN MUTATION. 2018;39(9):1214-1225
Germline variation in the oxidative DNA repair genes NUDT1 and OGG1 is not associated with hereditary colorectal cancer or polyposis
Mur P; Jemth A-S; Bevc L; Amaral N; Navarro M; Valdes-Mas R; Pons T; Aiza G; Urioste M; Valencia A; Lazaro C; Moreno V; Puente XS; Stenmark P; Warpman-Berglund U; Capella G; Helleday T; Valle L
Article: CELL DEATH & DISEASE. 2018;9(8):810
A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma
Einarsdottir BO; Karlsson J; Soderberg EMV; Lindberg MF; Funck-Brentano E; Jespersen H; Brynjolfsson SF; Bagge RO; Carstam L; Scobie M; Koolmeister T; Wallner O; Stierner U; Berglund UW; Ny L; Nilsson LM; Larsson E; Helleday T; Nilsson JA
Article: RSC MEDICINAL CHEMISTRY. 2018;9(7):1105-1113
A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate
Riley AM; Unterlass JE; Konieczny V; Taylor CW; Helleday T; Potter BVL
Article: NATURE COMMUNICATIONS. 2018;9(1):2419
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity
Berglund E; Maaskola J; Schultz N; Friedrich S; Marklund M; Bergenstrahle J; Tarish F; Tanoglidi A; Vickovic S; Larsson L; Salmen F; Ogris C; Wallenborg K; Lagergren J; Stahl P; Sonnhammer E; Helleday T; Lundeberg J
Article: CELL CYCLE. 2018;17(5):568-579
Distinct mechanistic responses to replication fork stalling induced by either nucleotide or protein deprivation
Henriksson S; Groth P; Gustafsson N; Helleday T
Article: STRUCTURE. 2018;26(2):295-303.e6
Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold
Carter M; Jemth A-S; Carreras-Puigvert J; Herr P; Carranza MM; Vallin KSA; Throup A; Helleday T; Stenmark P
Article: BIOCHEMISTRY. 2018;57(5):593-603
Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity
Narwal M; Jemth A-S; Gustafsson R; Almlof I; Berglund UW; Helleday T; Stenmark P
Article: ACTA ONCOLOGICA. 2018;57(2):187-194
U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden
Glimelius B; Melin B; Enblad G; Alafuzoff I; Beskow A; Ahlstrom H; Bill-Axelson A; Birgisson H; Bjor O; Edqvist P-H; Hansson T; Helleday T; Hellman P; Henriksson K; Hesselager G; Hultdin M; Haggman M; Hoglund M; Jonsson H; Larsson C; Lindman H; Ljuslinder I; Mindus S; Nygren P; Ponten F; Riklund K; Rosenquist R; Sandin F; Schwenk JM; Stenling R; Stalberg K; Stalberg P; Sundstrom C; Karlsson CT; Westermark B; Bergh A; Claesson-Welsh L; Palmqvist R; Sjoblom T
Article: NATURE COMMUNICATIONS. 2018;9(1):250
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
Page BDG; Valerie NCK; Wright RHG; Wallner O; Isaksson R; Carter M; Rudd SG; Loseva O; Jemth A-S; Almlof I; Font-Mateu J; Llona-Minguez S; Baranczewski P; Jeppsson F; Homan E; Almqvist H; Axelsson H; Regmi S; Gustavsson A-L; Lundback T; Scobie M; Stromberg K; Stenmark P; Beato M; Helleday T
Article: PLOS ONE. 2018;13(1):e0191231
Citrullinated histone H3 as a novel prognostic blood marker in patients with advanced cancer
Thalin C; Lundstrom S; Seignez C; Daleskog M; Lundstrom A; Henriksson P; Helleday T; Phillipson M; Wallen H; Demers M
Article: NATURE COMMUNICATIONS. 2017;8(1):1541
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family
Carreras-Puigvert J; Zitnik M; Jemth A-S; Carter M; Unterlass JE; Hallstrom B; Loseva O; Karem Z; Calderon-Montano JM; Lindskog C; Edqvist P-H; Matuszewski DJ; Blal HA; Berntsson RPA; Haggblad M; Martens U; Studham M; Lundgren B; Wahlby C; Sonnhammer ELL; Lundberg E; Stenmark P; Zupan B; Helleday T
Article: ONCOTARGET. 2017;8(49):84671-84684
Glioblastoma and glioblastoma stem cells are dependent on functional MTH1
Pudelko L; Rouhi P; Sanjiv K; Gad H; Kalderen C; Hoglund A; Squatrito M; Schuhmacher AJ; Edwards S; Hagerstrand D; Berglund UW; Helleday T; Brautigam L
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2017;60(19):8160-8169
Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space
Rudling A; Gustafsson R; Almlof I; Homan E; Scobie M; Berglund UW; Helleday T; Stenmark P; Carlsson J
Article: ORGANIC & BIOMOLECULAR CHEMISTRY. 2017;15(37):7758-7764
Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction
Llona-Minguez S; Throup A; Steiner E; Lightowler M; Van der Haegen S; Homan E; Eriksson L; Stenmark P; Jenmalm-Jensen A; Helleday T
Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2017;27(18):4462-4466
Tetrahydrobenzothiophene carboxamides: Beyond the kinase domain and into the fatty acid realm
Llona-Minguez S; Fayezi S; Alihemmati A; Juarez-Jimenez J; Piedrafita FJ; Helleday T
Article: DNA REPAIR. 2017;57:116-124
Zebularine induces replication-dependent double-strand breaks which are preferentially repaired by homologous recombination
Luis Orta M; Pastor N; Burgos-Moron E; Dominguez I; Manuel Calderon-Montano J; Huertas Castano C; Lopez-Lazaro M; Helleday T; Mateos S
Article: NATURE COMMUNICATIONS. 2017;8(1):374
Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer
Asim M; Tarish F; Zecchini HI; Sanjiv K; Gelali E; Massie CE; Baridi A; Warren AY; Zhao W; Ogris C; McDuffus L-A; Mascalchi P; Shaw G; Dev H; Wadhwa K; Wijnhoven P; Forment JV; Lyons SR; Lynch AG; O'Neill C; Zecchini VR; Rennie PS; Baniahmad A; Tavare S; Mills IG; Galanty Y; Crosetto N; Schultz N; Neal D; Helleday T
Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2017;27(16):3897-3904
Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 1: Triazoles, triazolopyrimidines, triazinoindoles, quinoline hydrazones and arylpiperazines
Llona-Minguez S; Haggblad M; Martens U; Throup A; Loseva O; Jemth A-S; Lundgren B; Scobie M; Helleday T
Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2017;27(15):3219-3225
Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems
Llona-Minguez S; Haggblad M; Martens U; Johansson L; Sigmundsson K; Lundback T; Loseva O; Jemth A-S; Lundgren B; Jensen AJ; Scobie M; Helleday T
Article: EXPERIMENTAL HEMATOLOGY. 2017;52:32-39
With me or against me: Tumor suppressor and drug resistance activities of SAMHD 1
Herold N; Rudd SG; Sanjiv K; Kutzner J; Myrberg IH; Paulin CBJ; Olsen TK; Helleday T; Henter J-I; Schaller T
Article: EMBO JOURNAL. 2017;36(14):2161-2176
ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration
Jaiswal H; Benada J; Mullers E; Akopyan K; Burdova K; Koolmeister T; Helleday T; Medema RH; Macurek L; Lindqvist A
Article: BIOMOLECULES. 2017;7(3):E49-49
Mutations in Cancer Cause Gain of Cysteine, Histidine, and Tryptophan at the Expense of a Net Loss of Arginine on the Proteome Level
Tsuber V; Kadamov Y; Brautigam L; Berglund UW; Helleday T
Article: RSC MEDICINAL CHEMISTRY. 2017;8(7):1553-1560
Structure-metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines
Llona-Minguez S; Ghassemian A; Baranczewski P; Desroses M; Koolmeister T; Artursson P; Scobie M; Helleday T
Article: CELL CYCLE. 2017;16(11):1029-1038
SAMHD1 protects cancer cells from various nucleoside-based antimetabolites
Herold N; Rudd SG; Sanjiv K; Kutzner J; Bladh J; Paulin CBJ; Helleday T; Henter J-I; Schaller T
Article: NATURE CHEMICAL BIOLOGY. 2017;13(6):681-690
Global survey of the immunomodulatory potential of common drugs
Vladimer GI; Snijder B; Krall N; Bigenzahn JW; Huber KVM; Lardeau C-H; Sanjiv K; Ringler A; Berglund UW; Sabler M; de la Fuente OL; Knoebl P; Kubicek S; Helleday T; Jaeger U; Superti-Furga G
Article: IMMUNOLOGIC RESEARCH. 2017;65(3):706-712
Validation of an enzyme-linked immunosorbent assay for the quantification of citrullinated histone H3 as a marker for neutrophil extracellular traps in human plasma
Thalin C; Daleskog M; Goransson SP; Schatzberg D; Lasselin J; Laska A-C; Kallner A; Helleday T; Wallen H; Demers M
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2017;60(10):4279-4292
Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors
Llona-Minguez S; Hoglund A; Ghassemian A; Desroses M; Calderon-Montano JM; Moron EB; Valerie NCK; Wiita E; Almlof I; Koolmeister T; Mateus A; Cazares-Korner C; Sanjiv K; Homan E; Loseva O; Baranczewski P; Darabi M; Mehdizadeh A; Fayezi S; Jemth A-S; Berglund UW; Sigmundsson K; Lundback T; Jensen AJ; Artursson P; Scobie M; Helleday T
Article: ONCOTARGET. 2017;8(14):23713-23726
dUTPase inhibition augments replication defects of 5-Fluorouracil
Hagenkort A; Paulin CBJ; Desroses M; Sarno A; Wiita E; Mortusewicz O; Koolmeister T; Loseva O; Jemth A-S; Almlof I; Homan E; Lundback T; Gustavsson A-L; Scobie M; Helleday T
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2017;60(5):2148-2154
Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1
Llona-Minguez S; Hoglund A; Wiita E; Almlof I; Mateus A; Calderon-Montano JM; Cazares-Korner C; Homan E; Loseva O; Baranczewski P; Jemth A-S; Haggblad M; Martens U; Lundgren B; Artursson P; Lundback T; Jensen AJ; Berglund UW; Scobie M; Helledayt T
Article: CANCER RESEARCH. 2017;77(4):937-948
Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor
Gustafsson R; Jemth A-S; Gustafsson NMS; Farnegardh K; Loseva O; Wiita E; Bonagas N; Dahllund L; Llona-Minguez S; Haggblad M; Henriksson M; Andersson Y; Homan E; Helleday T; Stenmark P
Article: NATURE MEDICINE. 2017;23(2):256-263
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies
Herold N; Rudd SG; Ljungblad L; Sanjiv K; Myrberg IH; Paulin CBJ; Heshmati Y; Hagenkort A; Kutzner J; Paget BDG; Calderon-Montano JM; Loseva O; Jemth A-S; Bulli L; Axelsson H; Tesi B; Valerie NCK; Hoglund A; Bladh J; Wiita E; Sundin M; Uhlin M; Rassidakis G; Heyman M; Tamm KP; Warpman-Berglund U; Walfridsson J; Lehmann S; Grander D; Lundback T; Kogner P; Henter J-I; Helleday T; Schaller T
Article: NUCLEIC ACIDS RESEARCH. 2017;45(2):e8
A novel method for crosstalk analysis of biological networks: improving accuracy of pathway annotation
Ogris C; Guala D; Helleday T; Sonnhammer ELL
Article: CELL CYCLE. 2017;16(2):189-199
Genome-wide screen of cell-cycle regulators in normal and tumor cells identifies a differential response to nucleosome depletion
Sokolova M; Turunen M; Mortusewicz O; Kivioja T; Herr P; Vaharautio A; Bjorklund M; Taipale M; Helleday T; Taipale J
Article: PLOS ONE. 2017;12(6):e0178844
Identification of novel small molecules that inhibit STAT3-dependent transcription and function
Kolosenko I; Yu Y; Busker S; Dyczynski M; Liu J; Haraldsson M; Apergi CP; Helleday T; Tamm KP; Page BDG; Grander D
Article: ONCOGENESIS. 2016;5(12):e280
The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing
Tanikawa M; Sanjiv K; Helleday T; Herr P; Mortusewicz O
Article: ONCOGENESIS. 2016;5(12):e275
hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia
Eshtad S; Mavajian Z; Rudd SG; Visnes T; Bostrom J; Altun M; Helleday T
Article: ANNALS OF ONCOLOGY. 2016;27(12):2275-2283
Validation and development of MTH1 inhibitors for treatment of cancer
Berglund UW; Sanjiv K; Gad H; Kalderen C; Koolmeister T; Pham T; Gokturk C; Jafari R; Maddalo G; Seashore-Ludlow B; Chernobrovkin A; Manoilov A; Pateras IS; Rasti A; Jemth A-S; Almlof I; Loseva O; Visnes T; Einarsdottir BO; Gaugaz FZ; Saleh A; Platzack B; Wallner OA; Vallin KSA; Henriksson M; Wakchaure P; Borhade S; Herr P; Kallberg Y; Baranczewski P; Homan EJ; Wiita E; Nagpal V; Meijer T; Schipper N; Rudd SG; Brautigam L; Lindqvist A; Filppula A; Lee T-C; Artursson P; Nilsson JA; Gorgoulis VG; Lehtio J; Zubarev RA; Scobie M; Helleday T
Article: CANCER RESEARCH. 2016;76(18):5501-5511
NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine
Valerie NCK; Hagenkort A; Page BDG; Masuyer G; Rehling D; Carter M; Bevc L; Herr P; Homan E; Sheppard NG; Stenmark P; Jemth A-S; Helleday T
Article: NUCLEIC ACIDS RESEARCH. 2016;44(W1):W105-W109
PathwAX: a web server for network crosstalk based pathway annotation
Ogris C; Helleday T; Sonnhammer ELL
Article: CELL DEATH & DISEASE. 2016;7(6):e2267
Overexpression of the scaffold WD40 protein WRAP53β enhances the repair of and cell survival from DNA double-strand breaks
Rassoolzadeh H; Bohm S; Hedstrom E; Gad H; Helleday T; Henriksson S; Farnebo M
Article: CANCER RESEARCH. 2016;76(8):2366-2375
Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition
Brautigam L; Pudelko L; Jemth A-S; Gad H; Narwal M; Gustafsson R; Karsten S; Puigvert JC; Homan E; Berndt C; Berglund UW; Stenmark P; Helleday T
Article: CANCER RESEARCH. 2016;76(5):1078-1088
DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair
Ying S; Chen Z; Medhurst AL; Neal JA; Bao Z; Mortusewicz O; McGouran J; Song X; Shen H; Hamdy FC; Kessler BM; Meek K; Helleday T
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2016;59(3):1140-1148
Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1
Llona-Minguez S; Hoglund A; Jacques SA; Johanson L; Calderon-Montano JM; Claesson M; Loseva O; Valerie NCK; Lundback T; Piedrafita J; Maga G; Crespan E; Meijer L; Moron EB; Baranczewski P; Hagbjork A-L; Svensson R; Wiita E; Almlof I; Visnes T; Jeppsson F; Sigmundsson K; Jensen AJ; Artursson P; Jemth A-S; Stenmark P; Berglund UW; Scobie M; Helleday T
Article: ONCOGENE. 2016;35(6):761-770
PC4 promotes genome stability and DNA repair through binding of ssDNA at DNA damage sites
Mortusewicz O; Evers B; Helleday T
Article: CELL REPORTS. 2016;14(2):298-309
Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities
Sanjiv K; Hagenkort A; Calderon-Montano JM; Koolmeister T; Reaper PM; Mortusewicz O; Jacques SA; Kuiper RV; Schultz N; Scobie M; Charlton PA; Pollard JR; Berglund UW; Altun M; Helleday T
Article: ONCOTARGET. 2015;6(35):37638-37646
Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response
Xing M; Wang X; Palmai-Pallag T; Shen H; Helleday T; Hickson ID; Ying S
Article: SCIENCE TRANSLATIONAL MEDICINE. 2015;7(312):312re11
Castration radiosensitizes prostate cancer tissue by impairing DNA double-strand break repair
Tarish FL; Schultz N; Tanoglidi A; Hamberg H; Letocha H; Karaszi K; Hamdy FC; Granfors T; Helleday T
Article: MOLECULAR CELL. 2015;60(1):163-176
Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair
Xie S; Mortusewicz O; Ma HT; Herr P; Poon RRY; Helleday T; Qian C
Article: MOLECULAR CELL. 2015;59(6):984-997
PARP1-and CTCF-Mediated Interactions between Active and Repressed Chromatin at the Lamina Promote Oscillating Transcription
Zhao H; Sifakis EG; Sumida N; Millan-Arino L; Scholz BA; Svensson JP; Chen X; Ronnegren AL; de Lima CDM; Varnoosfaderani FS; Shi C; Loseva O; Yammine S; Israelsson M; Rathje L-S; Nemeti B; Fredlund E; Helleday T; Imreh MP; Gondor A
Article: DNA REPAIR. 2015;33:101-110
Addiction to MTH1 protein results in intense expression in human breast cancer tissue as measured by liquid chromatography-isotope-dilution tandem mass spectrometry
Coskun E; Jaruga P; Jemth A-S; Loseva O; Scanlan LD; Tona A; Lowenthal MS; Helleday T; Dizdaroglu M
Article: NATURE COMMUNICATIONS. 2015;6:7871
Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2
Carter M; Jemth A-S; Hagenkort A; Page BDG; Gustafsson R; Griese JJ; Gad H; Valerie NCK; Desroses M; Bostrom J; Berglund UW; Helleday T; Stenmark P
Article: BIOCHEMICAL JOURNAL. 2015;468(2):293-301
Processing of protein ADP-ribosylation by Nudix hydrolases
Palazzo L; Thomas B; Jemth A-S; Colby T; Leidecker O; Feijs KLH; Zaja R; Loseva O; Puigvert JC; Matic I; Helleday T; Ahel I
Article: CHEMISTRY-A EUROPEAN JOURNAL. 2015;21(20):7394-7398
Vinylic MIDA Boronates: New Building Blocks for the Synthesis of Aza-Heterocycles
Llona-Minguez S; Desroses M; Ghassemian A; Jacques SA; Eriksson L; Isacksson R; Koolmeister T; Stenmark P; Scobie M; Helleday T
Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2015;104:1-11
Development and validation of method for TH588 and TH287, potent MTH1 inhibitors and new anti-cancer agents, for pharmacokinetic studies in mice plasma
Saleh A; Gokturk C; Warpman-Berglund U; Helleday T; Granelli I
Article: CELL DISCOVERY. 2015;1:15034
A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair
Herr P; Lundin C; Evers B; Ebner D; Bauerschmidt C; Kingham G; Palmai-Pallag T; Mortusewicz O; Frings O; Sonnhammer E; Helleday T
Article: GENES & DEVELOPMENT. 2014;28(24):2726-2738
The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair
Henriksson S; Rassoolzadeh H; Hedstrom E; Coucoravas C; Julner A; Goldstein M; Imreh G; Zhivotovsky B; Kastan MB; Helleday T; Farnebo M
Article: NUCLEIC ACIDS RESEARCH. 2014;42(14):9108-9120
The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions
Luis Orta M; Hoglund A; Manuel Calderon-Montano J; Dominguez I; Burgos-Moron E; Visnes T; Pastor N; Strom C; Lopez-Iazaro M; Helleday T
Article: PROTEOMES. 2014;2(3):341-362
Chronic Low Dose Rate Ionizing Radiation Exposure Induces Premature Senescence in Human Fibroblasts that Correlates with Up Regulation of Proteins Involved in Protection against Oxidative Stress
Loseva O; Shubbar E; Haghdoost S; Evers B; Helleday T; Harms-Ringdahl M
Article: CELL REPORTS. 2014;7(6):2006-2018
SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability
Pfister SX; Ahrabi S; Zalmas L-P; Sarkar S; Aymard F; Bachrati CZ; Helleday T; Legube G; La Thangue NB; Porter ACG; Humphrey TC
Article: SCIENTIFIC REPORTS. 2014;4:5372
Rational design and validation of a Tip60 histone acetyltransferase inhibitor
Gao C; Bourke E; Scobie M; Famme MA; Koolmeister T; Helleday T; Eriksson LA; Lowndes NF; Brown JAL
Article: NUCLEIC ACIDS RESEARCH. 2014;42(10):6326-6336
Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks
Bolderson E; Petermann E; Croft L; Suraweera A; Pandita RK; Pandita TK; Helleday T; Khanna KK; Richard DJ
Article: NATURE. 2014;508(7495):222-227
Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy
Huber KVM; Salah E; Radic B; Gridling M; Elkins JM; Stukalov A; Jemth A-S; Gokturk C; Sanjiv K; Stromberg K; Pham T; Berglund UW; Colinge J; Bennett KL; Loizou JI; Helleday T; Knapp S; Superti-Furga G
Article: NATURE. 2014;508(7495):215-221
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
Gad H; Koolmeister T; Jemth A-S; Eshtad S; Jacques SA; Strom CE; Svensson LM; Schultz N; Lundback T; Einarsdottir BO; Saleh A; Gokturk C; Baranczewski P; Svensson R; Berntsson RP-A; Gustafsson R; Stromberg K; Sanjiv K; Jacques-Cordonnier M-C; Desroses M; Gustavsson A-L; Olofsson R; Johansson F; Homan EJ; Loseva O; Brautigam L; Johansson L; Hoglund A; Hagenkort A; Pham T; Altun M; Gaugaz FZ; Vikingsson S; Evers B; Henriksson M; Vallin KSA; Wallner OA; Hammarstrom LGJ; Wiita E; Almlof I; Kalderen C; Axelsson H; Djureinovic T; Puigvert JC; Haggblad M; Jeppsson F; Martens U; Lundin C; Lundgren B; Granelli I; Jensen AJ; Artursson P; Nilsson JA; Stenmark P; Scobie M; Berglund UW; Helleday T
Article: SCIENCE. 2014;343(6166):88-91
Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells
Costantino L; Sotiriou SK; Rantala JK; Magin S; Mladenov E; Helleday T; Haber JE; Iliakis G; Kallioniemi OP; Halazonetis TD
Article: CELL CYCLE. 2013;12(24):3770-3780
SMG-1 suppresses CDK2 and tumor growth by regulating both the p53 and Cdc25A signaling pathways
Gubanova E; Issaeva N; Gokturk C; Djureinovic T; Helleday T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(42):16856-16861
Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity
Koepper F; Bierwirth C; Schoen M; Kunze M; Elvers I; Kranz D; Saini P; Menon MB; Walter D; Sorensen CS; Gaestel M; Helleday T; Schoen MP; Dobbelstein M
Article: CELL CYCLE. 2013;12(18):3037-3051
E2F-7 couples DNA damage-dependent transcription with the DNA repair process
Zalmas L-P; Coutts AS; Helleday T; La Thangue NB
Article: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2013;2013(26):5879-5885
A Convenient Microwave-Assisted Propylphosphonic Anhydride (T3P^®) Mediated One-Pot Pyrazolone Synthesis
Desroses M; Jacques-Cordonnier M-C; Llona-Minguez S; Jacques S; Koolmeister T; Helleday T; Scobie M
Article: ONCOGENE. 2013;32(32):3744-3753
Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress
Jones RM; Mortusewicz O; Afzal I; Lorvellec M; Garcia P; Helleday T; Petermann E
Article: TETRAHEDRON LETTERS. 2013;54(27):3554-3557
A facile and efficient synthesis of tetrahydro-β-carbolines
Desroses M; Koolmeister T; Jacques S; Llona-Minguez S; Jacques-Cordonnier M-C; Cazares-Korner A; Helleday T; Scobie M
Article: RADIOTHERAPY AND ONCOLOGY. 2013;108(1):155-161
Homologous recombination mediates cellular resistance and fraction size sensitivity to radiation therapy
Somaiah N; Yarnold J; Lagerqvist A; Rothkamm K; Helleday T
Article: NUCLEIC ACIDS RESEARCH. 2013;41(11):5827-5836
5-Aza-2'-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair
Luis Orta M; Manuel Calderon-Montano J; Dominguez I; Pastor N; Burgos-Moron E; Lopez-Lazaro M; Cortes F; Mateos S; Helleday T
Article: CLINICAL CANCER RESEARCH. 2013;19(6):1547-1556
Castration Therapy Results in Decreased Ku70 Levels in Prostate Cancer
Al-Ubaidi FLT; Schultz N; Loseva O; Egevad L; Granfors T; Helleday T
Article: NATURE. 2013;494(7438):492-496
Replication stress links structural and numerical cancer chromosomal instability
Burrell RA; McClelland SE; Endesfelder D; Groth P; Weller M-C; Shaikh N; Domingo E; Kanu N; Dewhurst SM; Gronroos E; Chew SK; Rowan AJ; Schenk A; Sheffer M; Howell M; Kschischo M; Behrens A; Helleday T; Bartek J; Tomlinson IR; Swanton C
Article: CARCINOGENESIS. 2013;34(2):325-330
Genotoxicity of alcohol is linked to DNA replication-associated damage and homologous recombination repair
Kotova N; Vare D; Schultz N; Meesters DG; Stepnik M; Grawe J; Helleday T; Jenssen D
Article: NEW JOURNAL OF CHEMISTRY. 2013;37(11):3595-3597
A new concise synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives
Desroses M; Scobie M; Helleday T
Article: CARCINOGENESIS. 2013;34(1):139-145
DNA damage response in peritumoral regions of oesophageal cancer microenvironment
He H; Tian D; Guo J; Liu M; Chen Z; Hamdy FC; Helleday T; Su M; Ying S
Article: BIOMOLECULES. 2012;2(4):635-649
Strategies for the Use of Poly(adenosine diphosphate ribose) Polymerase (PARP) Inhibitors in Cancer Therapy
Stroem CE; Helleday T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(50):42206-42222
Targeting Protein for Xenopus Kinesin-like Protein 2 (TPX2) Regulates γ-Histone 2AX (γ-H2AX) Levels upon Ionizing Radiation
Neumayer G; Helfricht A; Shim SY; Hoa TL; Lundin C; Belzil C; Chansard M; Yu Y; Lees-Miller SP; Gruss OJ; van Attikum H; Helleday T; Minh DN
Article: CARCINOGENESIS. 2012;33(11):2026-2034
Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta
Nicolay NH; Carter R; Hatch SB; Schultz N; Prevo R; McKenna WG; Helleday T; Sharma RA
Article: CLINICAL CANCER RESEARCH. 2012;18(19):5479-5488
The Relationship Between Homologous Recombination Repair and the Sensitivity of Human Epidermis to the Size of Daily Doses Over a 5-Week Course of Breast Radiotherapy
Somaiah N; Yarnold J; Daley F; Pearson A; Gothard L; Rothkamm K; Helleday T
Article: NUCLEIC ACIDS RESEARCH. 2012;40(17):8440-8448
CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation
Elvers I; Hagenkort A; Johansson F; Djureinovic T; Lagerqvist A; Schultz N; Stoimenov I; Erixon K; Helleday T
Article: NUCLEIC ACIDS RESEARCH. 2012;40(14):6585-6594
Homologous recombination repairs secondary replication induced DNA double-strand breaks after ionizing radiation
Groth P; Luis Orta M; Elvers I; Majumder MM; Lagerqvist A; Helleday T
Article: BIOCHEMICAL PHARMACOLOGY. 2012;83(11):1514-1522
Minor structural modifications to alchemix influence mechanism of action and pharmacological activity
Abdallah QMA; Phillips RM; Johansson F; Helleday T; Cosentino L; Abdel-Rahman H; Etzad J; Wheelhouse RT; Kiakos K; Bingham JP; Hartley JA; Patterson LH; Pors K
Article: CANCER RESEARCH. 2012;72(11):2814-2821
Mre11-Dependent Degradation of Stalled DNA Replication Forks Is Prevented by BRCA2 and PARP1
Ying S; Hamdy FC; Helleday T
Article: LIPIDS. 2012;47(4):355-361
N-Acyl Taurines are Anti-Proliferative in Prostate Cancer Cells
Chatzakos V; Slatis K; Djureinovic T; Helleday T; Hunt MC
Article: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2012;53(2):114-124
Uncoupling of RAD51 focus formation and cell survival after replication fork stalling in RAD51D null CHO cells
Urbin SS; Elvers I; Hinz JM; Helleday T; Thompson LH
Article: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 2012;82(3):1243-1248
CASTRATION THERAPY OF PROSTATE CANCER RESULTS IN DOWNREGULATION OF HIF-1α LEVELS
Al-Ubaidi FLT; Schultz N; Egevad L; Granfors T; Helleday T
Article: CLINICAL CANCER RESEARCH. 2012;18(5):1257-1267
Downregulation of SMG-1 in HPV-Positive Head and Neck Squamous Cell Carcinoma Due to Promoter Hypermethylation Correlates with Improved Survival
Gubanova E; Brown B; Ivanov SV; Helleday T; Mills GB; Yarbrough WG; Issaeva N
Article: CLINICAL CANCER RESEARCH. 2012;18(4):1015-1027
PTEN Deletion in Prostate Cancer Cells Does Not Associate with Loss of RAD51 Function: Implications for Radiotherapy and Chemotherapy
Fraser M; Zhao H; Luoto KR; Lundin C; Coackley C; Chan N; Joshua AM; Bismar TA; Evans A; Helleday T; Bristow RG
Article: MOLECULAR CANCER THERAPEUTICS. 2012;11(1):98-107
Targeted Mutations in the ATR Pathway Define Agent-Specific Requirements for Cancer Cell Growth and Survival
Wilsker D; Chung JH; Pradilla I; Petermann E; Helleday T; Bunz F
Article: DNA REPAIR. 2011;10(9):961-969
CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair
Strom CE; Mortusewicz O; Finch D; Parsons JL; Lagerqvist A; Johansson F; Schultz N; Erixon K; Dianov GL; Helleday T
Article: EUROPEAN JOURNAL OF CANCER. 2011;47:S333-S335
DNA repair as treatment target
Helleday T
Article: NUCLEIC ACIDS RESEARCH. 2011;39(16):7049-7057
UV stalled replication forks restart by re-priming in human fibroblasts
Elvers I; Johansson F; Groth P; Erixon K; Helleday T
Article: FEBS LETTERS. 2011;585(16):2617-2621
Crystal structure of human MTH1 and the 8-oxo-dGMP product complex
Svensson LM; Jemth A-S; Desroses M; Loseva O; Helleday T; Hoegbom M; Stenmark P
Article: RADIATION RESEARCH. 2011
Radiation Resistance in Cancer Therapy: Meeting Summary and Research Opportunities: Report of an NCI Workshop held September 1-3, 2010.
Glazer PM; Grandis J; Powell SN; Brown JM; Helleday T; Bristow R; Powis G; Hill RP; Le Q-T; Pelroy R; Mohla S; Bernhard EJ
Article: RADIATION RESEARCH. 2011;176(3):e0016-e0021
Radiation Resistance in Cancer Therapy: meeting summary and research opportunities. Report of an NCI Workshop held September 1-3, 2010.
Glazer PM; Grandis J; Powell SN; Brown JM; Helleday T; Bristow R; Powis G; Hill RP; Le Q-T; Pelroy R; Mohla S; Bernhard EJ; NCI Workshop Participants
Article: EMBO REPORTS. 2011;12(7):713-719
ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair
Segal-Raz H; Mass G; Baranes-Bachar K; Lerenthal Y; Wang S-Y; Chung YM; Ziv-Lehrman S; Strom CE; Helleday T; Hu MC-T; Chen DJ; Shiloh Y
Article: CANCER BIOLOGY & THERAPY. 2011;11(12):1028-1035
Breast cancer stem-like cells show dominant homologous recombination due to a larger S-G₂ fraction
Al-Assar O; Mantoni T; Lunardi S; Kingham G; Helleday T; Brunner TB
Article: PLOS ONE. 2011;6(5):e19659
FANCD1/BRCA2 Plays Predominant Role in the Repair of DNA Damage Induced by ACNU or TMZ
Kondo N; Takahashi A; Mori E; Noda T; Zdzienicka MZ; Thompson LH; Helleday T; Suzuki M; Kinashi Y; Masunaga S; Ono K; Hasegawa M; Ohnishi T
Article: PLOS ONE. 2011;6(5):e19492
Transcription Inhibition by DRB Potentiates Recombinational Repair of UV Lesions in Mammalian Cells
Stoimenov I; Schultz N; Gottipati P; Helleday T
Article: NUCLEIC ACIDS RESEARCH. 2011;39(8):3166-3175
Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate
Strom CE; Johansson F; Uhlen M; Szigyarto CA-K; Erixon K; Helleday T
Article: EXPERIMENTAL CELL RESEARCH. 2011;317(3):330-337
Cohesin phosphorylation and mobility of SMC1 at ionizing radiation-induced DNA double-strand breaks in human cells
Bauerschmidt C; Woodcock M; Stevens DL; Hill MA; Rothkamm K; Helleday T
Article: MOLECULAR CELL. 2011;41(2):210-220
miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors
Moskwa P; Buffa FM; Pan Y; Panchakshari R; Gottipati P; Muschel RJ; Beech J; Kulshrestha R; Abdelmohsen K; Weinstock DM; Gorospe M; Harris AL; Helleday T; Chowdhury D
Article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2011;706(1-2):1-6
Transcription inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) causes DNA damage and triggers homologous recombination repair in mammalian cells
Stoimenov I; Gottipati P; Schultz N; Helleday T
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;404(1):206-210
Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damage
Noda T; Takahashi A; Kondo N; Mori E; Okamoto N; Nakagawa Y; Ohnishi K; Zdzienicka MZ; Thompson LH; Helleday T; Asada H; Ohnishi T
Article: ONCOTARGET. 2010;1(7):606-619
Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks
Hawtin RE; Stockett DE; Wong OK; Lundin C; Helleday T; Fox JA
Article: MOLECULAR CELL. 2010;40(4):632-644
Identification of the MMS22L-TONSL Complex that Promotes Homologous Recombination
Duro E; Lundin C; Ask K; Sanchez-Pulido L; MacArtney TJ; Toth R; Ponting CP; Groth A; Helleday T; Rouse J
Article: MUTAGENESIS. 2010;25(6):623-629
The XPD subunit of TFIIH is required for transcription-associated but not DNA double-strand break-induced recombination in mammalian cells
Savolainen L; Cassel T; Helleday T
Article: CANCER RESEARCH. 2010;70(20):8045-8054
Contextual Synthetic Lethality of Cancer Cell Kill Based on the Tumor Microenvironment
Chan N; Pires IM; Bencokova Z; Coackley C; Luoto KR; Bhogal N; Lakshman M; Gottipati P; Oliver FJ; Helleday T; Hammond EM; Bristow RG
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(37):16090-16095
Chk1 promotes replication fork progression by controlling replication initiation
Petermann E; Woodcock M; Helleday T
Article: JOURNAL OF MOLECULAR BIOLOGY. 2010;402(1):70-82
Methylated DNA Causes a Physical Block to Replication Forks Independently of Damage Signalling, O⁶-Methylguanine or DNA Single-Strand Breaks and Results in DNA Damage
Groth P; Auslander S; Majumder MM; Schultz N; Johansson F; Petermann E; Helleday T
Article: DNA REPAIR. 2010;9(9):964-975
Human RECQL5 overcomes thymidine-induced replication stress
Blundred R; Myers K; Helleday T; Goldman ASH; Bryant HE
Article: CANCER RESEARCH. 2010;70(15):6268-6276
6-Thioguanine Selectively Kills BRCA2-Defective Tumors and Overcomes PARP Inhibitor Resistance
Issaeva N; Thomas HD; Djurenovic T; Jaspers JE; Stoimenov I; Kyle S; Pedley N; Gottipati P; Zur R; Sleeth K; Chatzakos V; Mulligan EA; Lundin C; Gubanova E; Kersbergen A; Harris AL; Sharma RA; Rottenberg S; Curtin NJ; Helleday T
Article: ONCOTARGET. 2010;1(3):175-184
Overexpression of POLQ Confers a Poor Prognosis in Early Breast Cancer Patients
Higgins GS; Harris AL; Prevo R; Helleday T; McKenna WG; Buffa FM
Article: CELL. 2010;142(1):65-76
Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2
MacKay C; Declais A-C; Lundin C; Agostinho A; Deans AJ; MacArtney TJ; Hofmann K; Gartner A; West SC; Helleday T; Lilley DMJ; Rouse J
Article: CANCER RESEARCH. 2010;70(13):5389-5398
Poly(ADP-Ribose) Polymerase Is Hyperactivated in Homologous Recombination-Defective Cells
Gottipati P; Vischioni B; Schultz N; Solomons J; Bryant HE; Djureinovic T; Issaeva N; Sleeth K; Sharma RA; Helleday T
Article: DNA REPAIR. 2010;9(7):835-841
XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair
Parsons JL; Dianova II; Finch D; Tait PS; Strom CE; Helleday T; Dianov GL
Article: CARCINOGENESIS. 2010;31(6):955-960
Homologous recombination in cancer development, treatment and development of drug resistance
Helleday T
Article: CANCER RESEARCH. 2010;70(7):2984-2993
A Small Interfering RNA Screen of Genes Involved in DNA Repair Identifies Tumor-Specific Radiosensitization by POLQ Knockdown
Higgins GS; Prevo R; Lee Y-F; Helleday T; Muschel RJ; Taylor S; Yoshimura M; Hickson ID; Bernhard EJ; McKenna WG
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(11):8054-8060
PARP-3 Is a Mono-ADP-ribosylase That Activates PARP-1 in the Absence of DNA
Loseva O; Jemth A-S; Bryant HE; Schuler H; Lehtio L; Karlberg T; Helleday T
Article: JOURNAL OF CELL BIOLOGY. 2010;188(5):629-638
Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase
Beck H; Nahse V; Larsen MSY; Groth P; Clancy T; Lees M; Jorgensen M; Helleday T; Syljuasen RG; Sorensen CS
Article: MOLECULAR CELL. 2010;37(4):492-502
Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair
Petermann E; Luis Orta M; Issaeva N; Schultz N; Helleday T
Article: DNA REPAIR. 2009;8(12):1424-1433
Specific targeted gene repair using single-stranded DNA oligonucleotides at an endogenous locus in mammalian cells uses homologous recombination
McLachlan J; Fernandez S; Helleday T; Bryant HE
Article: NUCLEIC ACIDS RESEARCH. 2009;37(19):6400-6413
The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links
Al-Minawi AZ; Lee Y-F; Hakansson D; Johansson F; Lundin C; Saleh-Gohari N; Schultz N; Jenssen D; Bryant HE; Meuth M; Hinz JM; Helleday T
Article: EMBO JOURNAL. 2009;28(17):2601-2615
PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination
Bryant HE; Petermann E; Schultz N; Jemth A-S; Loseva O; Issaeva N; Johansson F; Fernandez S; McGlynn P; Helleday T
Article: NUCLEIC ACIDS RESEARCH. 2009;37(15):5105-5113
BRCA2-dependent homologous recombination is required for repair of Arsenite-induced replication lesions in mammalian cells
Ying S; Myers K; Bottomley S; Helleday T; Bryant HE
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2009;52(9):3108-3111
Structural Basis for Inhibitor Specificity in Human Poly(ADP-ribose) Polymerase-3
Lehtio L; Jemth A-S; Collins R; Loseva O; Johansson A; Markova N; Hammarstrom M; Flores A; Holmberg-Schiavone L; Weigelt J; Helleday T; Schuler H; Karlberg T
Article: NUCLEIC ACIDS RESEARCH. 2009;37(2):405-412
Transcription-associated recombination is independent of XRCC2 and mechanistically separate from homology-directed DNA double-strand break repair
Savolainen L; Helleday T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(52):20752-20757
Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control
Wilsker D; Petermann E; Helleday T; Bunz F
Article: CLINICAL CANCER RESEARCH. 2008;14(17):5476-5483
Thymidine selectively enhances growth suppressive effects of camptothecin/irinotecan in MSI plus cells and tumors containing a mutation of MRE11
Rodriguez R; Hansen LT; Phear G; Scorah J; Spang-Thomsen M; Cox A; Helleday T; Meuth M
Article: MOLECULAR BIOLOGY OF THE CELL. 2008;19(9):3923-3933
WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks
Cheng W-H; Muftic D; Muftuoglu M; Dawut L; Morris C; Helleday T; Shiloh Y; Bohr VA
Article: JOURNAL OF APPLIED MICROBIOLOGY. 2008;105(1):290-299
Bacteriophage P2 integrase:: another possible tool for site-specific recombination in eukaryotic cells
Frumerie C; Sylwan L; Helleday T; Yu A; Haggard-Ljungquist E
Article: MOLECULAR BIOLOGY OF THE CELL. 2008;19(6):2373-2378
Claspin promotes normal replication fork rates in human cells
Petermann E; Helleday T; Caldecott KW
Article: JOURNAL OF MOLECULAR BIOLOGY. 2008;379(1):136-145
Zinc binding catalytic domain of human tankyrase 1
Lehtioe L; Collins R; van den Berg S; Johansson A; Dahlgren L-G; Hammarstroem M; Helleday T; Holmberg-Schiavone L; Karlberg T; Weigelt J
Article: MOLECULAR AND CELLULAR BIOLOGY. 2008;28(1):154-164
Transcription-associated recombination is dependent on replication in mammalian cells
Gottipati P; Cassel TN; Savolainen L; Helleday T
Article: NUCLEIC ACIDS RESEARCH. 2008;36(1):1-9
The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells
Al-Minawi AZ; Saleh-Gohari N; Helleday T
Article: JOURNAL OF CELL BIOLOGY. 2007;179(7):1337-1345
The histone methyltransferase SET8 is required for S-phase progression
Jorgensen S; Elvers I; Trelle MB; Menzel T; Eskildsen M; Jensen ON; Helleday T; Helin K; Sorensen CS
Article: JOURNAL OF MOLECULAR BIOLOGY. 2007;373(1):38-47
RPA mediates recombination repair during replication stress and is displaced from DNA by checkpoint signalling in human cells
Sleeth KM; Sorensen CS; Issaeva N; Dziegielewski J; Bartek J; Helleday T
Article: MOLECULAR AND CELLULAR BIOLOGY. 2007;27(7):2562-2571
RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair
Saberi A; Hochegger H; Szuts D; Lan L; Yasui A; Sale JE; Taniguchi Y; Murakawa Y; Zeng W; Yokomori K; Helleday T; Teraoka H; Arakawa H; Buerstedde J-M; Takeda S
Article: CYTOGENETIC AND GENOME RESEARCH. 2007;116(1-2):38-45
RAD51C (RAD51L2) is involved in maintaining centrosome number in mitosis
Lindh AR; Schultz N; Saleh-Gohari N; Helleday T
Article: DNA REPAIR. 2006;5(12):1449-1458
Caffeine delays replication fork progression and enhances UV-induced homologous recombination in Chinese hamster cell lines
Johansson F; Lagerqvist A; Filippi S; Palitti F; Erixon K; Helleday N; Jenssen D
Article: NATURE. 2006;444(7119):633-637
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
Bartkova J; Rezaei N; Liontos M; Karakaidos P; Kletsas D; Issaeva N; Vassiliou L-VF; Kolettas E; Niforou K; Zoumpourlis VC; Takaoka M; Nakagawa H; Tort F; Fugger K; Johansson F; Sehested M; Andersen CL; Dyrskjot L; Orntoft T; Lukas J; Kittas C; Helleday T; Halazonetis TD; Bartek J; Gorgoulis VG
Article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2006;599(1-2):116-123
Homologous recombination is involved in repair of chromium-induced DNA damage in mammalian cells
Bryant HE; Ying S; Helleday T
Article: HUMAN MOLECULAR GENETICS. 2006;15(7):1217-1224
Mitotic defects in XRCC3 variants T241M and D213N and their relation to cancer susceptibility
Lindh AR; Rafii S; Schultz N; Cox A; Helleday T
Article: NUCLEIC ACIDS RESEARCH. 2006;34(6):1685-1691
Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair
Bryant HE; Helleday T
Article: CELL CYCLE. 2005;4(9):1176-1178
Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy
Helleday T; Bryant HE; Schultz N
Article: MOLECULAR AND CELLULAR BIOLOGY. 2005;25(16):7158-7169
Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks
Saleh-Gohari N; Bryant HE; Schultz N; Parker KA; Cassel TN; Helleday T
Article: NUCLEIC ACIDS RESEARCH. 2005;33(12):3799-3811
Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks
Lundin C; North M; Erixon K; Walters K; Jenssen D; Goldman ASH; Helleday T
Article: MOLECULAR AND CELLULAR BIOLOGY. 2005;25(9):3553-3562
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
Syljuåsen RG; Sorensen CS; Hansen LT; Fugger K; Lundin C; Johansson F; Helleday T; Sehested M; Lukas J; Bartek J
Article: NATURE. 2005;434(7035):913-917
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
Bryant HE; Schultz N; Thomas HD; Parker KM; Flower D; Lopez E; Kyle S; Meuth M; Curtin NJ; Helleday T
Article: NATURE. 2005;434(7029):108-113
Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1
El-Khamisy SF; Saifi GM; Weinfeld M; Johansson F; Helleday T; Lupski JR; Caldecott KW
Article: NATURE CELL BIOLOGY. 2005;7(2):195-201
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
Sorensen CS; Hansen LT; Dziegielewski J; Syljuåsen RG; Lundin C; Bartek J; Helleday T
Article: CANCER RESEARCH. 2005;65(1):325-330
Up-regulation of the error-prone DNA polymerase κ promotes pleiotropic genetic alterations and tumorigenesis
Bavoux C; Leopoldino AM; Bergoglio V; O-Wang JY; Ogi T; Bieth A; Judde JG; Pena SDJ; Poupon MF; Helleday T; Tagawa M; Machado C; Hoffmann JS; Cazaux C
Article: ONCOGENE. 2004;23(56):9136-9141
Strand invasion involving short tract gene conversion is specifically suppressed in BRCA2-deficient hamster cells
Saleh-Gohari N; Helleday T
Article: HUMAN MOLECULAR GENETICS. 2004;13(23):2937-2945
ATM is required for the cellular response to thymidine induced replication fork stress
Bolderson E; Scorah J; Helleday T; Smythe C; Meuth M
Article: BIOCHEMICAL SOCIETY TRANSACTIONS. 2004;32(Pt 6):959-961
Poly(ADP-ribose) polymerase inhibitors as potential chemotherapeutic agents
Bryant HE; Helleday T
Article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2004;563(1):35-47
Screening for genotoxicity using the DRAG assay:: investigation of halogenated environmental contaminants
Johansson F; Allkvist A; Erixon K; Malmvärn A; Nilsson R; Bergman Å; Helleday T; Jenssen D
Article: NUCLEIC ACIDS RESEARCH. 2004;32(12):3683-3688
Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells
Saleh-Gohari N; Helleday T
Article: ONCOGENE. 2004;23(13):2324-2329
p53 protects from replication-associated DNA double-strand breaks in mammalian cells
Kumari A; Schultz N; Helleday T
Article: HUMAN MOLECULAR GENETICS. 2004;13(2):203-212
A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous recombination at DNA replication forks
Mohindra A; Bolderson E; Stone J; Wells M; Helleday T; Meuth M
Article: NUCLEIC ACIDS RESEARCH. 2003;31(17):4959-4964
Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination
Schultz N; Lopez E; Saleh-Gohari N; Helleday T
Article: INTERNATIONAL JOURNAL OF CANCER. 2003;105(4):472-479
The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer
Hansen LT; Lundin C; Spang-Thomsen M; Petersen LN; Helleday T
Article: JOURNAL OF MOLECULAR BIOLOGY. 2003;328(3):521-535
RAD51 is involved in repair of damage associated with DNA replication in mammalian cells
Lundin C; Schultz N; Arnaudeau C; Mohindra A; Hansen LT; Helleday T
Article: LUNG CANCER. 2003;40(2):157-164
DNA repair rate and etoposide (VP16) resistance of tumor cell subpopulations derived from a single human small cell lung cancer
Hansen LT; Lundin C; Helleday T; Poulsen HS; Sorensen CS; Petersen LN; Spang-Thomsen M
Article: CARCINOGENESIS. 2003;24(2):249-253
Reduced apoptotic response to camptothecin in CHO cells deficient in XRCC3
Hinz JM; Helleday T; Meuth M
Article: HUMAN MOLECULAR GENETICS. 2002;11(18):2189-2200
Defects in homologous recombination repair in mismatch-repair-deficient tumour cell lines
Mohindra A; Hays LE; Preston BD; Helleday T; Meuth M
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2002;296(2):363-367
Overexpression of cyclin E does not influence homologous recombination in Chinese hamster cells
Lundin C; Samuelsson MKR; Helleday T
Article: MOLECULAR AND CELLULAR BIOLOGY. 2002;22(16):5869-5878
Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells
Lundin C; Erixon K; Arnaudeau C; Schultz N; Jenssen D; Meuth M; Helleday T
Article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2001;493(1-2):55-66
ELF magnetic field affects proliferation of SPD8/V79 Chinese hamster cells but does not interact with intrachromosomal recombination
Olsson G; Belyaev IY; Helleday T; Harms-Ringdahl M
Article: JOURNAL OF MOLECULAR BIOLOGY. 2001;307(5):1235-1245
DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells
Arnaudeau C; Lundin C; Helleday T
Article: NUCLEIC ACIDS RESEARCH. 2001;29(3):662-667
RAD51 supports spontaneous non-homologous recombination in mammalian cells, but not the corresponding process induced by topoisomerase inhibitors
Arnaudeau C; Rozier L; Cazaux C; Defais M; Jenssen D; Helleday T
Article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2000;461(3):221-228
Inhibition of DNA synthesis is a potent mechanism by which cytostatic drugs induce homologous recombination in mammalian cells
Arnaudeau C; Miranda ET; Jenssen D; Helleday T
Article: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2000;35(2):114-122
Arsenic[III] and heavy metal ions induce intrachromosomal homologous recombination in the hprt gene of V79 Chinese hamster cells
Helleday T; Nilsson R; Jenssen D
Article: JOURNAL OF MOLECULAR BIOLOGY. 1999;289(5):1231-1238
The RAD51 protein supports homologous recombination by an exchange mechanism in mammalian cells
Arnaudeau C; Helleday T; Jenssen D
Article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 1999;439(2):137-147
Brominated flame retardants induce intragenic recombination in mammalian cells
Helleday T; Tuominen KL; Bergman A; Jenssen D
Article: JOURNAL OF MOLECULAR BIOLOGY. 1998;279(4):687-694
A partial HPRT gene duplication generated by non-homologous recombination in V79 Chinese hamster cells is eliminated by homologous recombination
Helleday T; Arnaudeau C; Jenssen D
Article: CARCINOGENESIS. 1998;19(6):973-978
Effects of carcinogenic agents upon different mechanisms for intragenic recombination in mammalian cells
Helleday T; Arnaudeau C; Jenssen D
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Employments

Professor, Department of Oncology-Pathology, Karolinska Institutet, 2018-

Degrees and Education

Docent, Stockholm University

Supervision

Johan Boström, Studying the Cell Cycle using Systems Biology and High Content Characterization of the Ubiquitin Proteasome System., https://openarchive.ki.se/xmlui/handle/10616/47323, 2014
Saeed Eshtad, Targeting DNA repair Pathways for Cancer Therapy., https://openarchive.ki.se/xmlui/handle/10616/45467, 2012

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