Sten Eirik Jacobsen

Om mig
Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Om mig

Sten Eirik Waelgaard Jacobsen, professor i stamcellsbiologi och regenerativ medicin vid institutionen för medicin i Huddinge och institutionen för cell- och molekylärbiologi, forskar om hur stamcellerna i benmärgen producerar blodceller. Forskningen handlar dels om den friska blodbildningen och hur den regleras, dels om orsakerna till olika blodsjukdomar, exempelvis leukemi.
Utbildning:

1987: Medicinska fakulteten, Universitetet i Bergen, Norge.

1992: PhD, Medicinska fakulteten, Institutionen för patologi, Universitetet i Bergen, Norge.

Utmärkelser/priser:

2024: Wallenberg Scholar 2024-2029, Knut och Alice Wallenberg Foundation.

2019: Vald stipendiat i Svensk Kungliga Vetenskapsakademien.

2019: Vald fellow i European Molecular Biology Organization (EMBO).

2015: Torsten Söderbergs Academy Professor i Medicine 2015, vald av Svensk Kungliga Vetenskapsakademien och Torsten Söderbergs akademien.

2014: Tobias Pris, delas ut av Svenska Kungliga Vetenskapsakademien och Tobiasstiftelsen till en forskare i ett av de nordiska länderna för enastående vetenskapliga insatser av relevans för blodsjukdomar och stamcellstransplantationer.

2005: Svensk Kungliga Vetenskapsakademien Göran Gustafssons pris för mest framstående unga forskare inom medicin i Sverige.

2003, 2004: Crafoords pris för bästa doktorsavhandling vid Medicinska fakulteten, Lunds universitet, Sverige 2003 (David Bryder) och 2004 (Lars Nilsson).

2000: Fernströmpriset till framstående unga utredare.

1999-2001: Stiftelsen för Strategisk Forskning: Pris/Anslag till ”Utstående unga utredare”.

1994: Malthepriset för bästa norska doktorsavhandling i internmedicin 1992-93.

Utvalda publikationer

Article: NATURE IMMUNOLOGY. 2024;25(6):1007-1019

Alternative platelet differentiation pathways initiated by nonhierarchically related hematopoietic stem cells.

Carrelha J; Mazzi S; Winroth A; Hagemann-Jensen M; Ziegenhain C; Högstrand K; Seki M; Brennan MS; Lehander M; Wu B; Meng Y; Markljung E; Norfo R; Ishida H; Belander Strålin K; Grasso F; Simoglou Karali C; Aliouat A; Hillen A; Chari E; Siletti K; Thongjuea S; Mead AJ; Linnarsson S; Nerlov C; Sandberg R; Yoshizato T; Woll PS; Jacobsen SEW
Article: NATURE BIOTECHNOLOGY. 2022;40(4):488-498

T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes.

Ali M; Giannakopoulou E; Li Y; Lehander M; Virding Culleton S; Yang W; Knetter C; Odabasi MC; Bollineni RC; Yang X; Foldvari Z; Böschen M-L; Taraldsrud E; Strønen E; Toebes M; Hillen A; Mazzi S; de Ru AH; Janssen GMC; Kolstad A; Tjønnfjord GE; Lie BA; Griffioen M; Lehmann S; Osnes LT; Buechner J; Garcia KC; Schumacher TN; van Veelen PA; Leisegang M; Jacobsen SEW; Woll P; Olweus J
Article: CANCER CELL. 2018;33(2):274-291.e8

Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.

Booth CAG; Barkas N; Neo WH; Boukarabila H; Soilleux EJ; Giotopoulos G; Farnoud N; Giustacchini A; Ashley N; Carrelha J; Jamieson L; Atkinson D; Bouriez-Jones T; Prinjha RK; Milne TA; Teachey DT; Papaemmanuil E; Huntly BJP; Jacobsen SEW; Mead AJ
Article: NATURE. 2018;554(7690):106-111

Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells.

Carrelha J; Meng Y; Kettyle LM; Luis TC; Norfo R; Alcolea V; Boukarabila H; Grasso F; Gambardella A; Grover A; Högstrand K; Lord AM; Sanjuan-Pla A; Woll PS; Nerlov C; Jacobsen SEW
Article: NATURE MEDICINE. 2017;23(6):692-702

Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia.

Giustacchini A; Thongjuea S; Barkas N; Woll PS; Povinelli BJ; Booth CAG; Sopp P; Norfo R; Rodriguez-Meira A; Ashley N; Jamieson L; Vyas P; Anderson K; Segerstolpe Å; Qian H; Olsson-Strömberg U; Mustjoki S; Sandberg R; Jacobsen SEW; Mead AJ
Article: NATURE IMMUNOLOGY. 2016;17(12):1424-1435

Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors.

Luis TC; Luc S; Mizukami T; Boukarabila H; Thongjuea S; Woll PS; Azzoni E; Giustacchini A; Lutteropp M; Bouriez-Jones T; Vaidya H; Mead AJ; Atkinson D; Böiers C; Carrelha J; Macaulay IC; Patient R; Geissmann F; Nerlov C; Sandberg R; de Bruijn MFTR; Blackburn CC; Godin I; Jacobsen SEW
Article: NATURE IMMUNOLOGY. 2016;17(6):666-676

Distinct myeloid progenitor-differentiation pathways identified through single-cell RNA sequencing.

Drissen R; Buza-Vidas N; Woll P; Thongjuea S; Gambardella A; Giustacchini A; Mancini E; Zriwil A; Lutteropp M; Grover A; Mead A; Sitnicka E; Jacobsen SEW; Nerlov C
Corrigendum: CANCER CELL. 2015;27(4):603-605

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo (vol 25, pg 794, 2014)

Woll PS; Kjaellquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstroem-Lindberg E; Linnarsson S; Jacobsen SEW
Article: CELL STEM CELL. 2013;13(5):535-548

Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells.

Böiers C; Carrelha J; Lutteropp M; Luc S; Green JCA; Azzoni E; Woll PS; Mead AJ; Hultquist A; Swiers G; Perdiguero EG; Macaulay IC; Melchiori L; Luis TC; Kharazi S; Bouriez-Jones T; Deng Q; Pontén A; Atkinson D; Jensen CT; Sitnicka E; Geissmann F; Godin I; Sandberg R; de Bruijn MFTR; Jacobsen SEW
Article: NATURE. 2013;502(7470):232-236

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy.

Sanjuan-Pla A; Macaulay IC; Jensen CT; Woll PS; Luis TC; Mead A; Moore S; Carella C; Matsuoka S; Bouriez Jones T; Chowdhury O; Stenson L; Lutteropp M; Green JCA; Facchini R; Boukarabila H; Grover A; Gambardella A; Thongjuea S; Carrelha J; Tarrant P; Atkinson D; Clark S-A; Nerlov C; Jacobsen SEW
Article: NEW ENGLAND JOURNAL OF MEDICINE. 2010;363(11):1025-1037

Persistent malignant stem cells in del(5q) myelodysplasia in remission.

Tehranchi R; Woll PS; Anderson K; Buza-Vidas N; Mizukami T; Mead AJ; Astrand-Grundström I; Strömbeck B; Horvat A; Ferry H; Dhanda RS; Hast R; Rydén T; Vyas P; Göhring G; Schlegelberger B; Johansson B; Hellström-Lindberg E; List A; Nilsson L; Jacobsen SEW
Article: CELL. 2005;121(2):295-306

Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment.

Adolfsson J; Månsson R; Buza-Vidas N; Hultquist A; Liuba K; Jensen CT; Bryder D; Yang L; Borge O-J; Thoren LAM; Anderson K; Sitnicka E; Sasaki Y; Sigvardsson M; Jacobsen SEW

Artiklar

Journal article: 2024;1(2):100011

Competition of dual SF3B1 mt clones in MDS-RS is associated with distinct RNA mis-splicing in hematopoietic stem cells

Moura PL; Nannya Y; Aliouat A; Hofman IJ; Mortera-Blanco T; Yoshizato T; Saiki R; Nakagawa MM; Creignou M; Björklund A-C; Walldin G; Barbosa I; Jansson M; Grasso F; Elvarsdottir EM; Woll PS; Jacobsen SEW; Ogawa S; Hellström-Lindberg E
Article: NATURE IMMUNOLOGY. 2024;25(6):955-956

Non-hierarchically related HSCs replenish platelets by distinct progenitor pathways.
Article: JOURNAL OF CLINICAL ONCOLOGY. 2024;42(12):1378-1390

Patient-Specific Measurable Residual Disease Markers Predict Outcome in Patients With Myelodysplastic Syndrome and Related Diseases After Hematopoietic Stem-Cell Transplantation.

Tobiasson M; Pandzic T; Illman J; Nilsson L; Weström S; Ejerblad E; Olesen G; Björklund A; Olsnes Kittang A; Werlenius O; Lorentz F; Rasmussen B; Cammenga J; Weber D; Lindholm C; Wiggh J; Dimitriou M; Moen AE; Yip Lundström L; von Bahr L; Baltzer-Sollander K; Jädersten M; Kytölä S; Walldin G; Ljungman P; Groenbaek K; Mielke S; Jacobsen SEW; Ebeling F; Cavelier L; Smidstrup Friis L; Dybedal I; Hellström-Lindberg E
Article: BLOOD. 2024;143(11):953-966

Identification and surveillance of rare relapse-initiating stem cells during complete remission after transplantation.

Dimitriou M; Mortera-Blanco T; Tobiasson M; Mazzi S; Lehander M; Högstrand K; Karimi M; Walldin G; Jansson M; Vonlanthen S; Ljungman P; Langemeijer S; Yoshizato T; Hellström-Lindberg E; Woll PS; Jacobsen SEW
Article: CANCER RESEARCH. 2024;84(2):211-225

Erythroid Differentiation Enhances RNA Mis-Splicing in SF3B1-Mutant Myelodysplastic Syndromes with Ring Sideroblasts.

Moura PL; Mortera-Blanco T; Hofman IJ; Todisco G; Kretzschmar WW; Björklund A-C; Creignou M; Hagemann-Jensen M; Ziegenhain C; Cabrerizo Granados D; Barbosa I; Walldin G; Jansson M; Ashley N; Mead AJ; Lundin V; Dimitriou M; Yoshizato T; Woll PS; Ogawa S; Sandberg R; Jacobsen SEW; Hellström-Lindberg E
Article: AUTOPHAGY. 2024;20(1):45-57

Autophagy preserves hematopoietic stem cells by restraining MTORC1-mediated cellular anabolism.

Borsa M; Obba S; Richter FC; Zhang H; Riffelmacher T; Carrelha J; Alsaleh G; Jacobsen SEW; Simon AK
Article: BLOOD. 2023;142(19):1622-1632

Loss of endothelial membrane KIT ligand affects systemic KIT ligand levels but not bone marrow hematopoietic stem cells.

Matsuoka S; Facchini R; Luis TC; Carrelha J; Woll PS; Mizukami T; Wu B; Boukarabila H; Buono M; Norfo R; Arai F; Suda T; Mead AJ; Nerlov C; Jacobsen SEW
Article: CLINICAL CANCER RESEARCH. 2023;29(20):4256-4267

Integrated Genomic and Transcriptomic Analysis Improves Disease Classification and Risk Stratification of MDS with Ring Sideroblasts.

Todisco G; Creignou M; Bernard E; Björklund A-C; Moura PL; Tesi B; Mortera-Blanco T; Sander B; Jansson M; Walldin G; Barbosa I; Reinsbach SE; Hofman IJ; Nilsson C; Yoshizato T; Dimitriou M; Chang D; Olafsdottir S; Venckute Larsson S; Tobiasson M; Malcovati L; Woll P; Jacobsen SEW; Papaemmanuil E; Hellström-Lindberg E
Article: NATURE CANCER. 2023;4(10):1474-1490

A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo.

Giannakopoulou E; Lehander M; Virding Culleton S; Yang W; Li Y; Karpanen T; Yoshizato T; Rustad EH; Nielsen MM; Bollineni RC; Tran TT; Delic-Sarac M; Gjerdingen TJ; Douvlataniotis K; Laos M; Ali M; Hillen A; Mazzi S; Chin DWL; Mehta A; Holm JS; Bentzen AK; Bill M; Griffioen M; Gedde-Dahl T; Lehmann S; Jacobsen SEW; Woll PS; Olweus J
Article: NATURE COMMUNICATIONS. 2023;14(1):6062

Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner.

Luis TC; Barkas N; Carrelha J; Giustacchini A; Mazzi S; Norfo R; Wu B; Aliouat A; Guerrero JA; Rodriguez-Meira A; Bouriez-Jones T; Macaulay IC; Jasztal M; Zhu G; Ni H; Robson MJ; Blakely RD; Mead AJ; Nerlov C; Ghevaert C; Jacobsen SEW
Article: NATURE GENETICS. 2023;55(9):1531-1541

Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution.

Rodriguez-Meira A; Norfo R; Wen S; Chédeville AL; Rahman H; O'Sullivan J; Wang G; Louka E; Kretzschmar WW; Paterson A; Brierley C; Martin J-E; Demeule C; Bashton M; Sousos N; Moralli D; Subha Meem L; Carrelha J; Wu B; Hamblin A; Guermouche H; Pasquier F; Marzac C; Girodon F; Vainchenker W; Drummond M; Harrison C; Chapman JR; Plo I; Jacobsen SEW; Psaila B; Thongjuea S; Antony-Debré I; Mead AJ
Journal article: HEMASPHERE. 2023;7(Suppl):e22964a1

P713: EXPLORING CLONAL COMPETITION THROUGH 12‐YEAR FOLLOW‐UP OF AN MDS‐RS PATIENT WITH DUAL SF3B1 MUTATIONS

Moura P; Hofman I; Nannya Y; Aliouat A; Mortera‐Blanco T; Yoshizato T; Saiki R; Nakagawa M; Björklund A; Walldin G; Barbosa I; Jansson M; Grasso F; Creignou M; Elvarsdottir E; Woll P; Jacobsen SE; Ogawa S; Lindberg EH
Article: GENOME BIOLOGY. 2023;24(1):152

Panhematopoietic RNA barcoding enables kinetic measurements of nucleate and anucleate lineages and the activation of myeloid clones following acute platelet depletion.

Wojtowicz EE; Mistry JJ; Uzun V; Hellmich C; Scoones A; Chin DW; Kettyle LM; Grasso F; Lord AM; Wright DJ; Etherington GJ; Woll PS; Belderbos ME; Bowles KM; Nerlov C; Haerty W; Bystrykh LV; Jacobsen SEW; Rushworth SA; Macaulay IC
Article: NATURE CELL BIOLOGY. 2023;25(6):812-822

Epigenetic programming defines haematopoietic stem cell fate restriction.

Meng Y; Carrelha J; Drissen R; Ren X; Zhang B; Gambardella A; Valletta S; Thongjuea S; Jacobsen SE; Nerlov C
Journal article: LEUKEMIA RESEARCH. 2023;128:107135

ACCELERATED RNA SPLICING DYNAMICS DURING ERYTHROID DIFFERENTIATION AMPLIFY MIS-SPLICING IN SF3B1-MUTANT MDS-RS

Moura P; Mortera-Blanco T; Hofman I; Todisco G; Kretzschmar W; Bjorklund A-C; Creignou M; Hagemann-Jensen M; Ziegenhain C; Granados D; Barbosa I; Walldin G; Jansson M; Mead A; Lundin V; Dimitriou M; Yoshizato T; Woll P; Ogawa S; Sandberg R; Jacobsen SE; Hellstrom-Lindberg E
Journal article: EXPERIMENTAL HEMATOLOGY. 2023;124:s64

3028 – LINEAGE BIASED HEMATOPOIETIC STEM CELLS AT TIME OF BIRTH

Strålin KB; Carrelha J; Kettyle L; Hillen A; Högstrand K; Markljung E; Grasso F; Seki M; Mazzi S; Meng Y; Wu B; Chari E; Lehander M; Woll P; Jacobsen SE
Journal article: HEMASPHERE. 2022;6:68-69

S167: PREDICTION OF RELAPSE AFTER ALLOGENEIC STEM CELL TRANSPLANTATION USING INDIVIDUALIZED MEASURABLE RESIDUAL DISEASE MARKERS; THE PROSPECTIVE NORDIC STUDY NMDSG14B

Tobiasson M; Pandzic T; Illman J; Nilsson L; Weström S; Sollander K; Ejerblad E; Kittang AO; Olesen G; Werlenius O; Björklund A; Wiggh J; lindholm C; Lorentz F; Rasmussen B; Cammenga J; Weber D; Grönnås D; Dimitriou M; Kytölä S; Walldin G; Ljungman P; Groenbeck K; Mielke S; Jacobsen SE; Ebeling F; Cavelier L; Friis LS; Dybedal I; Hellström‐Lindberg E
Article: BLOOD. 2022;139(4):629-634

Aged healthy mice acquire clonal hematopoiesis mutations.

Chin DWL; Yoshizato T; Virding Culleton S; Grasso F; Barbachowska M; Ogawa S; Jacobsen SEW; Woll PS
Article: JOURNAL OF IMMUNOLOGY. 2022;208(2):358-370

DNMT1 Deficiency Impacts on Plasmacytoid Dendritic Cells in Homeostasis and Autoimmune Disease.

Czeh M; Stäble S; Krämer S; Tepe L; Talyan S; Carrelha J; Meng Y; Heitplatz B; Schwabenland M; Milsom MD; Plass C; Prinz M; Schlesner M; Andrade-Navarro MA; Nerlov C; Jacobsen SEW; Lipka DB; Rosenbauer F
Journal article: EXPERIMENTAL HEMATOLOGY. 2022;111:s129-s130

3170 – SINGLE-CELL MULTI-OMICS RESOLVES THE EVOLUTION OF TP53-MUTANT LEUKEMIA

Rodriguez-Meira A; Norfo R; Wen W; Chedeville A; Rahman H; O'Sullivan J; Wang G; Louka E; Kretzschmar W; Paterson A; Brierley C; Martin J-E; Demeule C; Bashton M; Sousos N; Hamblin A; Guermouche H; Pasquier F; Marzac C; Girodon F; Drummond M; Harrison C; Plo I; Jacobsen SE; Psaila B; Thongjuea S; Antony-Debré I; Mead A
Journal article: EXPERIMENTAL HEMATOLOGY. 2022;111:s158

3227 – PARALLEL CLONAL AND MOLECULAR PROFILING OF HEMATOPOIETIC STEM CELLS USING RNA BARCODING

wojtowicz E; Mistry J; Uzun V; Scoones A; Chin D; Kettyle L; Lord A; Grasso F; Etherington G; Hellmich C; Woll P; Belderbos M; Bowles K; Bystrykh L; Nerlov C; Haerty W; Jacobsen SE; Rushworth S; Macaulay I
Journal article: EXPERIMENTAL HEMATOLOGY. 2022;111:s50

3011 – EPIGENETIC PROGRAMMING PREDICTS HEMATOPOIETIC STEM CELL FATE RESTRICTION AND PLATELET DIFFERENTIATION KINETICS

Meng Y; Carrelha J; Drissen R; Gambardella A; Thongjuea S; Jacobsen SE; Nerlov C
Article: CELL REPORTS. 2021;37(11):110103

The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition.

Azzoni E; Frontera V; Anselmi G; Rode C; James C; Deltcheva EM; Demian AS; Brown J; Barone C; Patelli A; Harman JR; Nicholls M; Conway SJ; Morrissey E; Jacobsen SEW; Sparrow DB; Harris AL; Enver T; de Bruijn MFTR
Article: NATURE COMMUNICATIONS. 2021;12(1):7019

Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors.

Neo WH; Meng Y; Rodriguez-Meira A; Fadlullah MZH; Booth CAG; Azzoni E; Thongjuea S; de Bruijn MFTR; Jacobsen SEW; Mead AJ; Lacaud G
Article: NATURE CANCER. 2021;2(8):835-852

Chemotherapy induces canalization of cell state in childhood B-cell precursor acute lymphoblastic leukemia.

Turati VA; Guerra-Assunção JA; Potter NE; Gupta R; Ecker S; Daneviciute A; Tarabichi M; Webster AP; Ding C; May G; James C; Brown J; Conde L; Russell LJ; Ancliff P; Inglott S; Cazzaniga G; Biondi A; Hall GW; Lynch M; Hubank M; Macaulay I; Beck S; Van Loo P; Jacobsen SE; Greaves M; Herrero J; Enver T
Article: JOURNAL OF INTERNAL MEDICINE. 2021;289(5):650-661

Stem cell concepts in myelodysplastic syndromes: lessons and challenges.

Woll PS; Jacobsen SEW
Article: DEVELOPMENT. 2021;148(3):dev194563

Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart.

Cahill TJ; Sun X; Ravaud C; Villa Del Campo C; Klaourakis K; Lupu I-E; Lord AM; Browne C; Jacobsen SEW; Greaves DR; Jackson DG; Cowley SA; James W; Choudhury RP; Vieira JM; Riley PR
Article: NATURE COMMUNICATIONS. 2021;12(1):464

Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice.

Papaioannou NE; Salei N; Rambichler S; Ravi K; Popovic J; Küntzel V; Lehmann CHK; Fiancette R; Salvermoser J; Gajdasik DW; Mettler R; Messerer D; Carrelha J; Ohnmacht C; Haller D; Stumm R; Straub T; Jacobsen SEW; Schulz C; Withers DR; Schotta G; Dudziak D; Schraml BU
Article: JOURNAL OF TRANSLATIONAL AUTOIMMUNITY. 2020;3:100066

cDC1 are required for the initiation of collagen-induced arthritis.

Ramos MI; Garcia S; Helder B; Aarrass S; Reedquist KA; Jacobsen SE; Tak PP; Lebre MC
Journal article: EXPERIMENTAL HEMATOLOGY. 2019;76:s77

PERIVASCULAR NICHE CELLS SENSE THROMBOCYTOPENIA AND ACTIVATE PLATELET-BIASED STEM CELLS IN AN IL-1 DEPENDENT MANNER

Luis T; Abdulla H; Davies T; Jackson J; Vo A; Alserihi R; Viney E; Wong T; Shi W; Alexander W; Dickins R; Shields B
Article: MOLECULAR CELL. 2019;73(6):1292-1305.e8

Unravelling Intratumoral Heterogeneity through High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA Sequencing.

Rodriguez-Meira A; Buck G; Clark S-A; Povinelli BJ; Alcolea V; Louka E; McGowan S; Hamblin A; Sousos N; Barkas N; Giustacchini A; Psaila B; Jacobsen SEW; Thongjuea S; Mead AJ
Article: NATURE CELL BIOLOGY. 2019;21(1):2-8

Haematopoiesis in the era of advanced single-cell technologies.

Jacobsen SEW; Nerlov C
Article: JOURNAL OF IMMUNOLOGY. 2018;201(11):3307-3319

Loss of Canonical Notch Signaling Affects Multiple Steps in NK Cell Development in Mice.

Chaves P; Zriwil A; Wittmann L; Boukarabila H; Peitzsch C; Jacobsen SEW; Sitnicka E
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2018;183(4):588-600

Direct role of FLT3 in regulation of early lymphoid progenitors.

Zriwil A; Böiers C; Kristiansen TA; Wittmann L; Yuan J; Nerlov C; Sitnicka E; Jacobsen SEW
Article: EMBO REPORTS. 2018;19(10):e45477

Kit ligand has a critical role in mouse yolk sac and aorta-gonad-mesonephros hematopoiesis.

Azzoni E; Frontera V; McGrath KE; Harman J; Carrelha J; Nerlov C; Palis J; Jacobsen SEW; de Bruijn MF
Article: ONCOSCIENCE. 2018;5(11-12):271-272

Origins of ETP leukemia.

Booth CAG; Jacobsen SEW; Mead AJ
Journal article: EXPERIMENTAL HEMATOLOGY. 2018;64:s97

3149 Single Cell Analysis Resolves Genetic and Transcriptional Heterogeneity in Myeloproliferative Neoplasms

Rodriguez-Meira A; Buck G; Clark S; Louka E; Povinelli B; Barkas N; McGowan S; Sousos N; Giustacchini A; Hamblin A; Jacobsen S; Thongjuea S; Mead A
Article: BLOOD. 2018;131(20):2223-2234

Cell-extrinsic hematopoietic impact of Ezh2 inactivation in fetal liver endothelial cells.

Neo WH; Booth CAG; Azzoni E; Chi L; Delgado-Olguín P; de Bruijn MFTR; Jacobsen SEW; Mead AJ
Article: BLOOD. 2018;131(15):1712-1719

Canonical Notch signaling is dispensable for adult steady-state and stress myelo-erythropoiesis.

Duarte S; Woll PS; Buza-Vidas N; Chin DWL; Boukarabila H; Luís TC; Stenson L; Bouriez-Jones T; Ferry H; Mead AJ; Atkinson D; Jin S; Clark S-A; Wu B; Repapi E; Gray N; Taylor S; Mutvei AP; Tsoi YL; Nerlov C; Lendahl U; Jacobsen SEW
Article: DEVELOPMENTAL CELL. 2018;44(3):362-377.e7

A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1.

Böiers C; Richardson SE; Laycock E; Zriwil A; Turati VA; Brown J; Wray JP; Wang D; James C; Herrero J; Sitnicka E; Karlsson S; Smith AJH; Jacobsen SEW; Enver T
Article: CELL STEM CELL. 2018;22(2):262-276.e7

In Vivo Labeling by CD73 Marks Multipotent Stromal Cells and Highlights Endothelial Heterogeneity in the Bone Marrow Niche.

Breitbach M; Kimura K; Luis TC; Fuegemann CJ; Woll PS; Hesse M; Facchini R; Rieck S; Jobin K; Reinhardt J; Ohneda O; Wenzel D; Geisen C; Kurts C; Kastenmüller W; Hölzel M; Jacobsen SEW; Fleischmann BK
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2017;214(10):3085-3104

Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program.

Loughran SJ; Comoglio F; Hamey FK; Giustacchini A; Errami Y; Earp E; Göttgens B; Jacobsen SEW; Mead AJ; Hendrich B; Green AR
Article: IMMUNITY. 2017;47(3):466-480.e5

Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation.

Riffelmacher T; Clarke A; Richter FC; Stranks A; Pandey S; Danielli S; Hublitz P; Yu Z; Johnson E; Schwerd T; McCullagh J; Uhlig H; Jacobsen SEW; Simon AK
Article: BLOOD. 2017;130(7):881-890

SF3B1-initiating mutations in MDS-RSs target lymphomyeloid hematopoietic stem cells.

Mortera-Blanco T; Dimitriou M; Woll PS; Karimi M; Elvarsdottir E; Conte S; Tobiasson M; Jansson M; Douagi I; Moarii M; Saft L; Papaemmanuil E; Jacobsen SEW; Hellström-Lindberg E
Article: CELL REPORTS. 2017;20(3):572-585

Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes.

Unnikrishnan A; Papaemmanuil E; Beck D; Deshpande NP; Verma A; Kumari A; Woll PS; Richards LA; Knezevic K; Chandrakanthan V; Thoms JAI; Tursky ML; Huang Y; Ali Z; Olivier J; Galbraith S; Kulasekararaj AG; Tobiasson M; Karimi M; Pellagatti A; Wilson SR; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen SEW; Mufti GJ; Hellstrom-Lindberg E; Wilkins MR; MacKenzie KL; Wong JWH; Campbell PJ; Pimanda JE
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2017;214(7):2005-2021

Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation.

Mead AJ; Neo WH; Barkas N; Matsuoka S; Giustacchini A; Facchini R; Thongjuea S; Jamieson L; Booth CAG; Fordham N; Di Genua C; Atkinson D; Chowdhury O; Repapi E; Gray N; Kharazi S; Clark S-A; Bouriez T; Woll P; Suda T; Nerlov C; Jacobsen SEW
Article: HAEMATOLOGICA. 2017;102(3):498-508

Progression in patients with low- and intermediate-1-risk del(5q) myelodysplastic syndromes is predicted by a limited subset of mutations.

Scharenberg C; Giai V; Pellagatti A; Saft L; Dimitriou M; Jansson M; Jädersten M; Grandien A; Douagi I; Neuberg DS; LeBlanc K; Boultwood J; Karimi M; Jacobsen SEW; Woll PS; Hellström-Lindberg E
Journal article: BLOOD. 2016;128(22):4329

Progression in Patients with with Low- and Intermediate-1 Risk Del(5q) MDS Is Predicted By a Limited Subset of Mutations

Scharenberg C; Woll PS; Giai V; Pellagatti A; Saft L; Dimitriou M; Jädersten M; Jansson M; Douagi I; Neuberg DS; Karimi M; Le Blanc K; Boultwood J; Jacobsen SE; Hellstrom-Lindberg E
Article: ONCOTARGET. 2016;7(45):72685-72698

Perturbed hematopoietic stem and progenitor cell hierarchy in myelodysplastic syndromes patients with monosomy 7 as the sole cytogenetic abnormality.

Dimitriou M; Woll PS; Mortera-Blanco T; Karimi M; Wedge DC; Doolittle H; Douagi I; Papaemmanuil E; Jacobsen SEW; Hellström-Lindberg E
Journal article: EXPERIMENTAL HEMATOLOGY. 2016;44(9):s46

DISTINCT MYELOID PROGENITOR DIFFERENTIATION PATHWAYS IDENTIFIED THROUGH SINGLE CELL RNA SEQUENCING

Nerlov C; Drissen R; Buza-Vidas N; Woll P; Thongjuea S; Gambardella A; Giustacchini A; Jacobsen SE
Article: CELL REPORTS. 2016;16(4):1039-1054

Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development.

Barrett NA; Malouf C; Kapeni C; Bacon WA; Giotopoulos G; Jacobsen SEW; Huntly BJ; Ottersbach K
Article: BLOOD. 2016;128(2):217-226

Macrophage colony-stimulating factor receptor marks and regulates a fetal myeloid-primed B-cell progenitor in mice.

Zriwil A; Böiers C; Wittmann L; Green JCA; Woll PS; Jacobsen SEW; Sitnicka E
Journal article: EUROPEAN JOURNAL OF CANCER. 2016;61:s104

481 Single cell analysis of intratumour heterogeneity in childhood acute lymphoblastic leukaemia

Turati V; Mike H; Herrero J; John A; Richardson S; Gaal B; Mark L; Jacobsen SE; Enver T
Article: CIRCULATION RESEARCH. 2016;118(10):1498-1511

Primitive Embryonic Macrophages are Required for Coronary Development and Maturation.

Leid J; Carrelha J; Boukarabila H; Epelman S; Jacobsen SEW; Lavine KJ
Article: NATURE COMMUNICATIONS. 2016;7:11075

Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells.

Grover A; Sanjuan-Pla A; Thongjuea S; Carrelha J; Giustacchini A; Gambardella A; Macaulay I; Mancini E; Luis TC; Mead A; Jacobsen SEW; Nerlov C
Article: NATURE CELL BIOLOGY. 2016;18(2):157-167

A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors.

Buono M; Facchini R; Matsuoka S; Thongjuea S; Waithe D; Luis TC; Giustacchini A; Besmer P; Mead AJ; Jacobsen SEW; Nerlov C
Article: CELL DEATH DISCOVERY. 2015;1:15008

Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia.

Watson AS; Riffelmacher T; Stranks A; Williams O; De Boer J; Cain K; MacFarlane M; McGouran J; Kessler B; Khandwala S; Chowdhury O; Puleston D; Phadwal K; Mortensen M; Ferguson D; Soilleux E; Woll P; Jacobsen SEW; Simon AK
Article: NATURE COMMUNICATIONS. 2015;6:6930

PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium.

Noseda M; Harada M; McSweeney S; Leja T; Belian E; Stuckey DJ; Abreu Paiva MS; Habib J; Macaulay I; de Smith AJ; al-Beidh F; Sampson R; Lumbers RT; Rao P; Harding SE; Blakemore AIF; Jacobsen SE; Barahona M; Schneider MD
Article: ANNALS OF THE RHEUMATIC DISEASES. 2015;74(1):211-219

Absence of Fms-like tyrosine kinase 3 ligand (Flt3L) signalling protects against collagen-induced arthritis.

Ramos MIP; Karpus ON; Broekstra P; Aarrass S; Jacobsen SE; Tak PP; Lebre MC
Article: LEUKEMIA. 2015;29(1):38-50

Clonal variegation and dynamic competition of leukemia-initiating cells in infant acute lymphoblastic leukemia with MLL rearrangement.

Bardini M; Woll PS; Corral L; Luc S; Wittmann L; Ma Z; Lo Nigro L; Basso G; Biondi A; Cazzaniga G; Jacobsen SEW
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2014;93(5):439-445

A pilot phase I dose finding safety study of the thrombopoietin-receptor agonist, eltrombopag, in patients with myelodysplastic syndrome treated with azacitidine.

Svensson T; Chowdhury O; Garelius H; Lorenz F; Saft L; Jacobsen S-E; Hellström-Lindberg E; Cherif H
Article: CANCER CELL. 2014;25(6):794-808

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.

Woll PS; Kjällquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Göhring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellström-Lindberg E; Linnarsson S; Jacobsen SEW
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2014;211(2):181-188

Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate.

Grover A; Mancini E; Moore S; Mead AJ; Atkinson D; Rasmussen KD; O'Carroll D; Jacobsen SEW; Nerlov C
Article: CELL REPORTS. 2013;3(6):1766-1776

FLT3-ITDs instruct a myeloid differentiation and transformation bias in lymphomyeloid multipotent progenitors.

Mead AJ; Kharazi S; Atkinson D; Macaulay I; Pecquet C; Loughran S; Lutteropp M; Woll P; Chowdhury O; Luc S; Buza-Vidas N; Ferry H; Clark S-A; Goardon N; Vyas P; Constantinescu SN; Sitnicka E; Nerlov C; Jacobsen SEW
Article: IMMUNITY. 2013;38(5):930-942

Transcriptional repression of Gata3 is essential for early B cell commitment.

Banerjee A; Northrup D; Boukarabila H; Jacobsen SEW; Allman D
Article: BLOOD. 2013;121(20):4156-4165

Impact of isolated germline JAK2V617I mutation on human hematopoiesis.

Mead AJ; Chowdhury O; Pecquet C; Dusa A; Woll P; Atkinson D; Burns A; Score J; Rugless M; Clifford R; Moule S; Bienz N; Vyas P; Cross N; Gale RE; Henderson S; Constantinescu SN; Schuh A; Jacobsen SEW
Article: NATURE CELL BIOLOGY. 2013;15(4):363-372

Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis.

Moignard V; Macaulay IC; Swiers G; Buettner F; Schütte J; Calero-Nieto FJ; Kinston S; Joshi A; Hannah R; Theis FJ; Jacobsen SE; de Bruijn MF; Göttgens B
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2013;160(6):842-850

Silencing of ASXL1 impairs the granulomonocytic lineage potential of human CD34⁺ progenitor cells.

Davies C; Yip BH; Fernandez-Mercado M; Woll PS; Agirre X; Prosper F; Jacobsen SE; Wainscoat JS; Pellagatti A; Boultwood J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(43):17579-17584

Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21.

Roy A; Cowan G; Mead AJ; Filippi S; Bohn G; Chaidos A; Tunstall O; Chan JKY; Choolani M; Bennett P; Kumar S; Atkinson D; Wyatt-Ashmead J; Hu M; Stumpf MPH; Goudevenou K; O'Connor D; Chou ST; Weiss MJ; Karadimitris A; Jacobsen SE; Vyas P; Roberts I
Article: BLOOD. 2012;120(12):2412-2416

Dicer is selectively important for the earliest stages of erythroid development.

Buza-Vidas N; Cismasiu VB; Moore S; Mead AJ; Woll PS; Lutteropp M; Melchiori L; Luc S; Bouriez-Jones T; Atkinson D; O'Carroll D; Jacobsen SEW; Nerlov C
Article: BLOOD. 2012;120(1):63-75

Emergence of NK-cell progenitors and functionally competent NK-cell lineage subsets in the early mouse embryo.

Tang Y; Peitzsch C; Charoudeh HN; Cheng M; Chaves P; Jacobsen SEW; Sitnicka E
Article: LEUKEMIA. 2012;26(7):1527-1536

Molecular and cellular effects of oncogene cooperation in a genetically accurate AML mouse model.

Reckzeh K; Bereshchenko O; Mead A; Rehn M; Kharazi S; Jacobsen S-E; Nerlov C; Cammenga J
Article: JOURNAL OF NEUROSCIENCE. 2012;32(15):5151-5164

Adaptor protein LNK is a negative regulator of brain neural stem cell proliferation after stroke.

Ahlenius H; Devaraju K; Monni E; Oki K; Wattananit S; Darsalia V; Iosif RE; Torper O; Wood JC; Braun S; Jagemann L; Nuber UA; Englund E; Jacobsen S-EW; Lindvall O; Kokaia Z
Article: SCIENCE. 2012;336(6077):86-90

A lineage of myeloid cells independent of Myb and hematopoietic stem cells.

Schulz C; Gomez Perdiguero E; Chorro L; Szabo-Rogers H; Cagnard N; Kierdorf K; Prinz M; Wu B; Jacobsen SEW; Pollard JW; Frampton J; Liu KJ; Geissmann F
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2012;209(3):537-549

Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow.

Mansour A; Abou-Ezzi G; Sitnicka E; Jacobsen SEW; Wakkach A; Blin-Wakkach C
Article: NATURE IMMUNOLOGY. 2012;13(4):412-419

The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential.

Luc S; Luis TC; Boukarabila H; Macaulay IC; Buza-Vidas N; Bouriez-Jones T; Lutteropp M; Woll PS; Loughran SJ; Mead AJ; Hultquist A; Brown J; Mizukami T; Matsuoka S; Ferry H; Anderson K; Duarte S; Atkinson D; Soneji S; Domanski A; Farley A; Sanjuan-Pla A; Carella C; Patient R; de Bruijn M; Enver T; Nerlov C; Blackburn C; Godin I; Jacobsen SEW
Article: EMBO JOURNAL. 2012;31(2):351-365

FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors.

Mancini E; Sanjuan-Pla A; Luciani L; Moore S; Grover A; Zay A; Rasmussen KD; Luc S; Bilbao D; O'Carroll D; Jacobsen SE; Nerlov C
Article: PLOS GENETICS. 2011;7(12):e1002404

Acute multiple organ failure in adult mice deleted for the developmental regulator Wt1.

Chau Y-Y; Brownstein D; Mjoseng H; Lee W-C; Buza-Vidas N; Nerlov C; Jacobsen SE; Perry P; Berry R; Thornburn A; Sexton D; Morton N; Hohenstein P; Freyer E; Samuel K; van't Hof R; Hastie N
Article: BLOOD. 2011;118(13):3613-3621

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.

Kharazi S; Mead AJ; Mansour A; Hultquist A; Böiers C; Luc S; Buza-Vidas N; Ma Z; Ferry H; Atkinson D; Reckzeh K; Masson K; Cammenga J; Rönnstrand L; Arai F; Suda T; Nerlov C; Sitnicka E; Jacobsen SEW
Article: BLOOD. 2011;118(6):1544-1548

FLT3 expression initiates in fully multipotent mouse hematopoietic progenitor cells.

Buza-Vidas N; Woll P; Hultquist A; Duarte S; Lutteropp M; Bouriez-Jones T; Ferry H; Luc S; Jacobsen SEW
Article: BLOOD. 2011;118(5):1291-1293

GATA3 is redundant for maintenance and self-renewal of hematopoietic stem cells.

Buza-Vidas N; Duarte S; Luc S; Bouriez-Jones T; Woll PS; Jacobsen SEW
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2011;208(8):1563-1570

Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors.

Pronk CJH; Veiby OP; Bryder D; Jacobsen SEW
Article: EPIGENETICS & CHROMATIN. 2011;4(1):9

Generation of bivalent chromatin domains during cell fate decisions.

De Gobbi M; Garrick D; Lynch M; Vernimmen D; Hughes JR; Goardon N; Luc S; Lower KM; Sloane-Stanley JA; Pina C; Soneji S; Renella R; Enver T; Taylor S; Jacobsen SEW; Vyas P; Gibbons RJ; Higgs DR
Article: BLOOD. 2011;117(13):3521-3528

Hoxb4-YFP reporter mouse model: a novel tool for tracking HSC development and studying the role of Hoxb4 in hematopoiesis.

Hills D; Gribi R; Ure J; Buza-Vidas N; Luc S; Jacobsen SEW; Medvinsky A
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2011;208(3):455-467

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance.

Mortensen M; Soilleux EJ; Djordjevic G; Tripp R; Lutteropp M; Sadighi-Akha E; Stranks AJ; Glanville J; Knight S; Jacobsen S-EW; Kranc KR; Simon AK
Article: CANCER CELL. 2011;19(1):138-152

Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia.

Goardon N; Marchi E; Atzberger A; Quek L; Schuh A; Soneji S; Woll P; Mead A; Alford KA; Rout R; Chaudhury S; Gilkes A; Knapper S; Beldjord K; Begum S; Rose S; Geddes N; Griffiths M; Standen G; Sternberg A; Cavenagh J; Hunter H; Bowen D; Killick S; Robinson L; Price A; Macintyre E; Virgo P; Burnett A; Craddock C; Enver T; Jacobsen SEW; Porcher C; Vyas P
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2010;150(3):293-302

Maintenance treatment with azacytidine for patients with high-risk myelodysplastic syndromes (MDS) or acute myeloid leukaemia following MDS in complete remission after induction chemotherapy.

Grövdal M; Karimi M; Khan R; Aggerholm A; Antunovic P; Astermark J; Bernell P; Engström L-M; Kjeldsen L; Linder O; Nilsson L; Olsson A; Holm MS; Tangen JM; Wallvik J; Oberg G; Hokland P; Jacobsen SE; Porwit A; Hellström-Lindberg E
Article: BLOOD. 2010;116(2):183-192

Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells.

Nozad Charoudeh H; Tang Y; Cheng M; Cilio CM; Jacobsen SEW; Sitnicka E
Article: BLOOD. 2010;115(24):5061-5068

Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development.

Böiers C; Buza-Vidas N; Jensen CT; Pronk CJH; Kharazi S; Wittmann L; Sitnicka E; Hultquist A; Jacobsen SEW
Article: CELL STEM CELL. 2009;5(6):659-665

Cited2 is an essential regulator of adult hematopoietic stem cells.

Kranc KR; Schepers H; Rodrigues NP; Bamforth S; Villadsen E; Ferry H; Bouriez-Jones T; Sigvardsson M; Bhattacharya S; Jacobsen SE; Enver T
Article: CANCER CELL. 2009;16(5):390-400

Hematopoietic stem cell expansion precedes the generation of committed myeloid leukemia-initiating cells in C/EBPalpha mutant AML.

Bereshchenko O; Mancini E; Moore S; Bilbao D; Månsson R; Luc S; Grover A; Jacobsen SEW; Bryder D; Nerlov C
Article: NATURE GENETICS. 2009;41(11):1207-1215

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.

Bröske A-M; Vockentanz L; Kharazi S; Huska MR; Mancini E; Scheller M; Kuhl C; Enns A; Prinz M; Jaenisch R; Nerlov C; Leutz A; Andrade-Navarro MA; Jacobsen SEW; Rosenbauer F
Article: GLIA. 2009;57(8):835-849

Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke.

Thored P; Heldmann U; Gomes-Leal W; Gisler R; Darsalia V; Taneera J; Nygren JM; Jacobsen S-EW; Ekdahl CT; Kokaia Z; Lindvall O
Article: BLOOD. 2009;113(19):4790-4798

Polyclonal T-cell reconstitution of X-SCID recipients after in utero transplantation of lymphoid-primed multipotent progenitors.

Liuba K; Pronk CJH; Stott SRW; Jacobsen S-EW
Article: BLOOD. 2009;113(15):3453-3460

FLT3 receptor and ligand are dispensable for maintenance and posttransplantation expansion of mouse hematopoietic stem cells.

Buza-Vidas N; Cheng M; Duarte S; Charoudeh HN; Jacobsen SEW; Sitnicka E
Article: BLOOD. 2009;113(12):2661-2672

High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle.

Tipping AJ; Pina C; Castor A; Hong D; Rodrigues NP; Lazzari L; May GE; Jacobsen SEW; Enver T
Article: JOURNAL OF IMMUNOLOGY. 2009;182(3):1460-1468

Distinct and overlapping patterns of cytokine regulation of thymic and bone marrow-derived NK cell development.

Cheng M; Charoudeh HN; Brodin P; Tang Y; Lakshmikanth T; Höglund P; Jacobsen SEW; Sitnicka E
Article: CYTOTHERAPY. 2009;11(2):114-128

Characterization of bone marrow-derived mesenchymal stromal cells (MSC) based on gene expression profiling of functionally defined MSC subsets.

Tormin A; Brune JC; Olsson E; Valcich J; Neuman U; Olofsson T; Jacobsen S-E; Scheding S
Article: BLOOD. 2008;112(6):2297-2304

FLT3 ligand and not TSLP is the key regulator of IL-7-independent B-1 and B-2 B lymphopoiesis.

Jensen CT; Kharazi S; Böiers C; Cheng M; Lübking A; Sitnicka E; Jacobsen SEW
Article: BLOOD. 2008;112(4):1048-1055

B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells.

Mansson R; Zandi S; Anderson K; Martensson I-L; Jacobsen SEW; Bryder D; Sigvardsson M
Article: MOLECULAR CANCER. 2008;7:67

Exit of pediatric pre-B acute lymphoblastic leukaemia cells from the bone marrow to the peripheral blood is not associated with cell maturation or alterations in gene expression.

Hansson F; Toporski J; Månsson R; Johansson B; Norén-Nyström U; Jacobsen SEW; Wiebe T; Larsson M; Sigvardsson M; Castor A
Article: GENES & DEVELOPMENT. 2008;22(10):1381-1396

NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements.

Weischenfeldt J; Damgaard I; Bryder D; Theilgaard-Mönch K; Thoren LA; Nielsen FC; Jacobsen SEW; Nerlov C; Porse BT
Article: NATURE CELL BIOLOGY. 2008;10(5):584-592

Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.

Nygren JM; Liuba K; Breitbach M; Stott S; Thorén L; Roell W; Geisen C; Sasse P; Kirik D; Björklund A; Nerlov C; Fleischmann BK; Jovinge S; Jacobsen SEW
Article: CANCER CELL. 2008;13(4):299-310

Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells.

Kirstetter P; Schuster MB; Bereshchenko O; Moore S; Dvinge H; Kurz E; Theilgaard-Mönch K; Månsson R; Pedersen TA; Pabst T; Schrock E; Porse BT; Jacobsen SEW; Bertone P; Tenen DG; Nerlov C
Article: BLOOD. 2008;111(7):3424-3434

Down-regulation of Mpl marks the transition to lymphoid-primed multipotent progenitors with gradual loss of granulocyte-monocyte potential.

Luc S; Anderson K; Kharazi S; Buza-Vidas N; Böiers C; Jensen CT; Ma Z; Wittmann L; Jacobsen SEW
Article: BLOOD. 2008;111(4):2083-2090

Permissive roles of hematopoietin and cytokine tyrosine kinase receptors in early T-cell development.

Jensen CT; Böiers C; Kharazi S; Lübking A; Rydén T; Sigvardsson M; Sitnicka E; Jacobsen SEW
Article: JOURNAL OF IMMUNOLOGY. 2008;180(4):2045-2053

Kit regulates maintenance of quiescent hematopoietic stem cells.

Thorén LA; Liuba K; Bryder D; Nygren JM; Jensen CT; Qian H; Antonchuk J; Jacobsen S-EW
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2008;83(1):156-164

Involvement of CCR9 at multiple stages of adult T lymphopoiesis.

Svensson M; Marsal J; Uronen-Hansson H; Cheng M; Jenkinson W; Cilio C; Jacobsen SEW; Sitnicka E; Anderson G; Agace WW
Article: BLOOD. 2008;111(1):112-121

Protein kinase B (c-akt) regulates hematopoietic lineage choice decisions during myelopoiesis.

Buitenhuis M; Verhagen LP; van Deutekom HWM; Castor A; Verploegen S; Koenderman L; Jacobsen S-EW; Coffer PJ
Article: CELL STEM CELL. 2007;1(6):671-684

Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells.

Qian H; Buza-Vidas N; Hyland CD; Jensen CT; Antonchuk J; Månsson R; Thoren LA; Ekblom M; Alexander WS; Jacobsen SEW
Article: CLINICAL CANCER RESEARCH. 2007;13(23):7107-7112

Negative effect of DNA hypermethylation on the outcome of intensive chemotherapy in older patients with high-risk myelodysplastic syndromes and acute myeloid leukemia following myelodysplastic syndrome.

Grövdal M; Khan R; Aggerholm A; Antunovic P; Astermark J; Bernell P; Engström L-M; Kjeldsen L; Linder O; Nilsson L; Olsson A; Wallvik J; Tangen JM; Oberg G; Jacobsen SE; Hokland P; Porwit A; Hellström-Lindberg E
Article: BLOOD. 2007;110(8):3005-3014

The molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes.

Nilsson L; Edén P; Olsson E; Månsson R; Astrand-Grundström I; Strömbeck B; Theilgaard-Mönch K; Anderson K; Hast R; Hellström-Lindberg E; Samuelsson J; Bergh G; Nerlov C; Johansson B; Sigvardsson M; Borg A; Jacobsen SEW
Article: BLOOD. 2007;110(8):2955-2964

Critical role of FLT3 ligand in IL-7 receptor independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors.

Sitnicka E; Buza-Vidas N; Ahlenius H; Cilio CM; Gekas C; Nygren JM; Månsson R; Cheng M; Jensen CT; Svensson M; Leandersson K; Agace WW; Sigvardsson M; Jacobsen SEW
Article: BLOOD. 2007;110(7):2399-2407

Distinct roles of integrins alpha6 and alpha4 in homing of fetal liver hematopoietic stem and progenitor cells.

Qian H; Georges-Labouesse E; Nyström A; Domogatskaya A; Tryggvason K; Jacobsen SEW; Ekblom M
Article: CANCER CELL. 2007;12(4):367-380

FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia.

Lee BH; Tothova Z; Levine RL; Anderson K; Buza-Vidas N; Cullen DE; McDowell EP; Adelsperger J; Fröhling S; Huntly BJP; Beran M; Jacobsen SE; Gilliland DG
Article: BLOOD. 2007;110(4):1362-1369

Potential risks of bone marrow cell transplantation into infarcted hearts.

Breitbach M; Bostani T; Roell W; Xia Y; Dewald O; Nygren JM; Fries JWU; Tiemann K; Bohlen H; Hescheler J; Welz A; Bloch W; Jacobsen SEW; Fleischmann BK
Article: CURRENT OPINION IN HEMATOLOGY. 2007;14(4):315-321

Delineation of the earliest lineage commitment steps of haematopoietic stem cells: new developments, controversies and major challenges.

Buza-Vidas N; Luc S; Jacobsen SEW
Article: BLOOD. 2007;110(1):424-432

Crucial role of FLT3 ligand in immune reconstitution after bone marrow transplantation and high-dose chemotherapy.

Buza-Vidas N; Cheng M; Duarte S; Nozad H; Jacobsen SEW; Sitnicka E
Article: CANCER RESEARCH. 2007;67(12):5727-5736

CD133 is not present on neurogenic astrocytes in the adult subventricular zone, but on embryonic neural stem cells, ependymal cells, and glioblastoma cells.

Pfenninger CV; Roschupkina T; Hertwig F; Kottwitz D; Englund E; Bengzon J; Jacobsen SE; Nuber UA
Article: EMBO JOURNAL. 2007;26(9):2361-2370

Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction.

Fujimoto T; Anderson K; Jacobsen SEW; Nishikawa S-I; Nerlov C
Article: BLOOD. 2007;109(9):3697-3705

Ectopic expression of PAX5 promotes maintenance of biphenotypic myeloid progenitors coexpressing myeloid and B-cell lineage-associated genes.

Anderson K; Rusterholz C; Månsson R; Jensen CT; Bacos K; Zandi S; Sasaki Y; Nerlov C; Sigvardsson M; Jacobsen SEW
Article: IMMUNITY. 2007;26(4):407-419

Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors.

Månsson R; Hultquist A; Luc S; Yang L; Anderson K; Kharazi S; Al-Hashmi S; Liuba K; Thorén L; Adolfsson J; Buza-Vidas N; Qian H; Soneji S; Enver T; Sigvardsson M; Jacobsen SEW
Journal article: BLOOD. 2006;108(11):83

Enforced Expression of GATA-2 Confers Quiescence on Human Hematopoietic Stem and Progenitor Cells In Vitro and In Vivo.

Tipping AJ; Pina C; Castor A; Atzberger A; Hong D; Lazzari L; May G; Jacobsen SE; Enver T
Journal article: BLOOD. 2006;108(11):3208

Crucial Role of FLT3 Ligand in Immune Reconstitution Following Bone Marrow Transplantation and High Dose Chemotherapy.

Buza-Vidas N; Cheng M; Duarte S; Jacobsen SEW; Sitnicka E
Journal article: PLOS BIOLOGY. 2006;4(11):1923-1933

Two-step recruitment of RNA-directed DNA methylation to tandem repeats.

Chan SW-L; Zhang X; Bernatavichute YV; Jacobsen SE
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2006;203(10):2315-2327

Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium.

Kolossov E; Bostani T; Roell W; Breitbach M; Pillekamp F; Nygren JM; Sasse P; Rubenchik O; Fries JWU; Wenzel D; Geisen C; Xia Y; Lu Z; Duan Y; Kettenhofen R; Jovinge S; Bloch W; Bohlen H; Welz A; Hescheler J; Jacobsen SE; Fleischmann BK
Article: NATURE IMMUNOLOGY. 2006;7(10):1048-1056

Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block.

Kirstetter P; Anderson K; Porse BT; Jacobsen SEW; Nerlov C
Journal article: JOURNAL OF CELL BIOLOGY. 2006;174(7):i13

Engraftment of engineered ES cell–derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium

Kolossov E; Bostani T; Roell W; Breitbach M; Pillekamp F; Nygren JM; Sasse P; Rubenchik O; Fries JWU; Wenzel D; Geisen C; Xia Y; Lu Z; Duan Y; Kettenhofen R; Jovinge S; Bloch W; Bohlen H; Welz A; Hescheler J; Jacobsen SE; Fleischmann BK
Article: JOURNAL OF NEUROSCIENCE. 2006;26(38):9703-9712

Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis.

Iosif RE; Ekdahl CT; Ahlenius H; Pronk CJH; Bonde S; Kokaia Z; Jacobsen S-EW; Lindvall O
Article: GENES & DEVELOPMENT. 2006;20(15):2018-2023

Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK.

Buza-Vidas N; Antonchuk J; Qian H; Månsson R; Luc S; Zandi S; Anderson K; Takaki S; Nygren JM; Jensen CT; Jacobsen SEW
Article: JOURNAL OF IMMUNOLOGY. 2006;177(1):201-208

Prolonged cell cycle transit is a defining and developmentally conserved hemopoietic stem cell property.

Nygren JM; Bryder D; Jacobsen SEW
Article: STEM CELLS. 2006;24(6):1594-1604

Failure of transdifferentiation of adult hematopoietic stem cells into neurons.

Roybon L; Ma Z; Asztely F; Fosum A; Jacobsen SEW; Brundin P; Li J-Y
Article: BLOOD. 2006;107(9):3503-3510

Contribution of alpha6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with alpha4 integrins.

Qian H; Tryggvason K; Jacobsen SE; Ekblom M
Article: DIABETES. 2006;55(2):290-296

Failure of transplanted bone marrow cells to adopt a pancreatic beta-cell fate.

Taneera J; Rosengren A; Renstrom E; Nygren JM; Serup P; Rorsman P; Jacobsen SEW
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2005;202(1):85-96

Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage.

Porse BT; Bryder D; Theilgaard-Mönch K; Hasemann MS; Anderson K; Damgaard I; Jacobsen SEW; Nerlov C
Article: NATURE MEDICINE. 2005;11(6):630-637

Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia.

Castor A; Nilsson L; Astrand-Grundström I; Buitenhuis M; Ramirez C; Anderson K; Strömbeck B; Garwicz S; Békássy AN; Schmiegelow K; Lausen B; Hokland P; Lehmann S; Juliusson G; Johansson B; Jacobsen SEW
Article: BLOOD. 2005;105(11):4272-4281

Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2.

Buitenhuis M; van Deutekom HWM; Verhagen LP; Castor A; Jacobsen SEW; Lammers J-WJ; Koenderman L; Coffer PJ
Article: BLOOD. 2005;105(7):2717-2723

Identification of Lin(-)Sca1(+)kit(+)CD34(+)Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients.

Yang L; Bryder D; Adolfsson J; Nygren J; Månsson R; Sigvardsson M; Jacobsen SEW
Article: JOURNAL OF GENE MEDICINE. 2005;7(2):137-144

Deficiency of oncoretrovirally transduced hematopoietic stem cells and correction through ex vivo expansion.

Bryder D; Björgvinsdóttir H; Sasaki Y; Jacobsen SEW
Article: JOURNAL OF IMMUNOLOGY. 2005;174(2):752-757

IFN-gamma negatively modulates self-renewal of repopulating human hemopoietic stem cells.

Yang L; Dybedal I; Bryder D; Nilsson L; Sitnicka E; Sasaki Y; Jacobsen SEW
Article: HAEMATOLOGICA. 2005;90(1):38-44

Biosynthetic profiles of neutrophil serine proteases in a human bone marrow-derived cellular myeloid differentiation model.

Garwicz D; Lennartsson A; Jacobsen SEW; Gullberg U; Lindmark A
Article: GENES CHROMOSOMES & CANCER. 2004;41(3):223-231

MDS/AML-associated cytogenetic abnormalities in multiple myeloma and monoclonal gammopathy of undetermined significance: evidence for frequent de novo occurrence and multipotent stem cell involvement of del(20q).

Nilsson T; Nilsson L; Lenhoff S; Rylander L; Astrand-Grundström I; Strömbeck B; Höglund M; Turesson I; Westin J; Mitelman F; Jacobsen SEW; Johansson B
Article: BLOOD. 2004;104(4):986-992

Enforced expression of cyclin D2 enhances the proliferative potential of myeloid progenitors, accelerates in vivo myeloid reconstitution, and promotes rescue of mice from lethal myeloablation.

Sasaki Y; Jensen CT; Karlsson S; Jacobsen SEW
Article: BMC IMMUNOLOGY. 2004;5:16

P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+ stem and progenitor cells.

Wang L; Jacobsen SEW; Bengtsson A; Erlinge D
Article: NATURE MEDICINE. 2004;10(5):494-501

Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation.

Nygren JM; Jovinge S; Breitbach M; Säwén P; Röll W; Hescheler J; Taneera J; Fleischmann BK; Jacobsen SEW
Article: JOURNAL OF IMMUNOLOGY. 2004;172(3):1548-1552

Deceptive multilineage reconstitution analysis of mice transplanted with hemopoietic stem cells, and implications for assessment of stem cell numbers and lineage potentials.

Bryder D; Sasaki Y; Borge OJ; Jacobsen S-EW
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2003;198(10):1495-1506

Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis.

Sitnicka E; Brakebusch C; Martensson I-L; Svensson M; Agace WW; Sigvardsson M; Buza-Vidas N; Bryder D; Cilio CM; Ahlenius H; Maraskovsky E; Peschon JJ; Jacobsen SEW
Article: BLOOD. 2003;102(3):881-886

Human CD34+ hematopoietic stem cells capable of multilineage engrafting NOD/SCID mice express flt3: distinct flt3 and c-kit expression and response patterns on mouse and candidate human hematopoietic stem cells.

Sitnicka E; Buza-Vidas N; Larsson S; Nygren JM; Liuba K; Jacobsen SEW
Article: BLOOD. 2003;102(1):118-126

Human reconstituting hematopoietic stem cells up-regulate Fas expression upon active cell cycling but remain resistant to Fas-induced suppression.

Dybedal I; Yang L; Bryder D; Aastrand-Grundstrom I; Leandersson K; Jacobsen SEW
Article: BLOOD. 2003;101(3):877-885

Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells.

Gu Y-C; Kortesmaa J; Tryggvason K; Persson J; Ekblom P; Jacobsen S-E; Ekblom M
Article: IMMUNITY. 2002;17(4):463-472

Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool.

Sitnicka E; Bryder D; Theilgaard-Mönch K; Buza-Vidas N; Adolfsson J; Jacobsen SEW
Article: BLOOD. 2002;100(1):259-267

Involvement and functional impairment of the CD34(+)CD38(-)Thy-1(+) hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8.

Nilsson L; Astrand-Grundström I; Anderson K; Arvidsson I; Hokland P; Bryder D; Kjeldsen L; Johansson B; Hellström-Lindberg E; Hast R; Jacobsen SEW
Article: HUMAN GENE THERAPY. 2002;13(9):1061-1073

Efficient oncoretroviral transduction of extended long-term culture-initiating cells and NOD/SCID repopulating cells: enhanced reconstitution with gene-marked cells through an ex vivo expansion approach.

Björgvinsdóttir H; Bryder D; Sitnicka E; Ramsfjell V; De Jong I; Olsson K; Rusterholz C; Karlsson S; Jacobsen SEW
Article: JOURNAL OF IMMUNOLOGY. 2002;168(2):755-762

Transient disruption of autocrine TGF-beta signaling leads to enhanced survival and proliferation potential in single primitive human hemopoietic progenitor cells.

Fan X; Valdimarsdottir G; Larsson J; Brun A; Magnusson M; Jacobsen SE; ten Dijke P; Karlsson S
Article: IMMUNITY. 2001;15(4):659-669

Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity.

Adolfsson J; Borge OJ; Bryder D; Theilgaard-Mönch K; Astrand-Grundström I; Sitnicka E; Sasaki Y; Jacobsen SE
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2001;194(7):941-952

Self-renewal of multipotent long-term repopulating hematopoietic stem cells is negatively regulated by Fas and tumor necrosis factor receptor activation.

Bryder D; Ramsfjell V; Dybedal I; Theilgaard-Mönch K; Högerkorp CM; Adolfsson J; Borge OJ; Jacobsen SE
Article: BLOOD. 2001;98(6):1782-1791

Tumor necrosis factor (TNF)-mediated activation of the p55 TNF receptor negatively regulates maintenance of cycling reconstituting human hematopoietic stem cells.

Dybedal I; Bryder D; Fossum A; Rusten LS; Jacobsen SE
Article: JOURNAL OF VIROLOGY. 2000;74(24):11911-11918

Lentivirus gene transfer in murine hematopoietic progenitor cells is compromised by a delay in proviral integration and results in transduction mosaicism and heterogeneous gene expression in progeny cells.

Mikkola H; Woods NB; Sjögren M; Helgadottir H; Hamaguchi I; Jacobsen SE; Trono D; Karlsson S
Article: BLOOD. 2000;96(12):3725-3733

Lentiviral gene transfer into primary and secondary NOD/SCID repopulating cells.

Woods NB; Fahlman C; Mikkola H; Hamaguchi I; Olsson K; Zufferey R; Jacobsen SE; Trono D; Karlsson S
Article: BLOOD. 2000;96(6):2012-2021

Isolation and characterization of hematopoietic progenitor/stem cells in 5q-deleted myelodysplastic syndromes: evidence for involvement at the hematopoietic stem cell level.

Nilsson L; Astrand-Grundström I; Arvidsson I; Jacobsson B; Hellström-Lindberg E; Hast R; Jacobsen SE
Article: BLOOD. 2000;96(5):1748-1755

Interleukin-3 supports expansion of long-term multilineage repopulating activity after multiple stem cell divisions in vitro.

Bryder D; Jacobsen SE
Article: BLOOD. 2000;96(4):1457-1464

Cloning of human early B-cell factor and identification of target genes suggest a conserved role in B-cell development in man and mouse.

Gisler R; Jacobsen SE; Sigvardsson M
Article: HUMAN GENE THERAPY. 2000;11(9):1313-1327

Efficient adenoviral vector transduction of human hematopoietic SCID-repopulating and long-term culture-initiating cells.

Fan X; Brun A; Segrén S; Jacobsen SE; Karlsson S
Article: BLOOD. 1999;94(12):4093-4102

Distinct requirements for optimal growth and In vitro expansion of human CD34(+)CD38(-) bone marrow long-term culture-initiating cells (LTC-IC), extended LTC-IC, and murine in vivo long-term reconstituting stem cells.

Ramsfjell V; Bryder D; Björgvinsdóttir H; Kornfält S; Nilsson L; Borge OJ; Jacobsen SE
Article: BLOOD. 1999;94(11):3781-3790

Lymphoid-restricted development from multipotent candidate murine stem cells: distinct and complimentary functions of the c-kit and flt3-ligands.

Borge OJ; Adolfsson J; Mårtensson A; Mårtensson IL; Jacobsen SE
Article: BLOOD. 1999;94(6):1971-1978

Involvement of the retinoblastoma protein in monocytic and neutrophilic lineage commitment of human bone marrow progenitor cells.

Bergh G; Ehinger M; Olsson I; Jacobsen SE; Gullberg U
Article: BLOOD. 1997;90(11):4321-4331

Bidirectional effect of interleukin-10 on early murine B-cell development: stimulation of flt3-ligand plus interleukin-7-dependent generation of CD19(-) ProB cells from uncommitted bone marrow progenitor cells and growth inhibition of CD19(+) ProB cells.

Veiby OP; Borge OJ; Mârtensson A; Beck EX; Schade AE; Grzegorzewski K; Lyman SD; Mârtensson IL; Jacobsen SE
Article: BLOOD. 1997;90(9):3395-3403

Transforming growth factor-beta1 abrogates Fas-induced growth suppression and apoptosis of murine bone marrow progenitor cells.

Dybedal I; Guan F; Borge OJ; Veiby OP; Ramsfjell V; Nagata S; Jacobsen SE
Article: BLOOD. 1997;90(6):2282-2292

Ability of early acting cytokines to directly promote survival and suppress apoptosis of human primitive CD34+CD38- bone marrow cells with multilineage potential at the single-cell level: key role of thrombopoietin.

Borge OJ; Ramsfjell V; Cui L; Jacobsen SE
Article: JOURNAL OF IMMUNOLOGY. 1997;159(4):1961-1969

Thrombopoietin promotes adhesion of primitive human hemopoietic cells to fibronectin and vascular cell adhesion molecule-1: role of activation of very late antigen (VLA)-4 and VLA-5.

Cui L; Ramsfjell V; Borge OJ; Veiby OP; Lok S; Jacobsen SE
Article: BLOOD. 1997;89(12):4415-4424

Interleukin-13 in combination with CD40 ligand potently inhibits apoptosis in human B lymphocytes: upregulation of Bcl-xL and Mcl-1.

Lømo J; Blomhoff HK; Jacobsen SE; Krajewski S; Reed JC; Smeland EB
Article: JOURNAL OF IMMUNOLOGY. 1997;158(11):5169-5177

Thrombopoietin directly and potently stimulates multilineage growth and progenitor cell expansion from primitive (CD34+ CD38-) human bone marrow progenitor cells: distinct and key interactions with the ligands for c-kit and flt3, and inhibitory effects of TGF-beta and TNF-alpha.

Ramsfjell V; Borge OJ; Cui L; Jacobsen SE
Article: BLOOD. 1996;88(12):4481-4492

Thrombopoietin, but not erythropoietin, directly stimulates multilineage growth of primitive murine bone marrow progenitor cells in synergy with early acting cytokines: distinct interactions with the ligands for c-kit and FLT3.

Ramsfjell V; Borge OJ; Veiby OP; Cardier J; Murphy MJ; Lyman SD; Lok S; Jacobsen SE
Article: BLOOD. 1996;88(8):2859-2870

Thrombopoietin, but not erythropoietin promotes viability and inhibits apoptosis of multipotent murine hematopoietic progenitor cells in vitro.

Borge OJ; Ramsfjell V; Veiby OP; Murphy MJ; Lok S; Jacobsen SE
Article: JOURNAL OF IMMUNOLOGY. 1996;157(7):2953-2960

The flt3 ligand promotes the survival of primitive hemopoietic progenitor cells with myeloid as well as B lymphoid potential. Suppression of apoptosis and counteraction by TNF-alpha and TGF-beta.

Veiby OP; Jacobsen FW; Cui L; Lyman SD; Jacobsen SE
Article: BLOOD. 1996;88(4):1256-1265

Combined signaling through interleukin-7 receptors and flt3 but not c-kit potently and selectively promotes B-cell commitment and differentiation from uncommitted murine bone marrow progenitor cells.

Veiby OP; Lyman SD; Jacobsen SE
Article: JOURNAL OF IMMUNOLOGY. 1996;157(3):1193-1199

TNF-alpha bidirectionally modulates the viability of primitive murine hematopoietic progenitor cells in vitro.

Jacobsen FW; Veiby OP; Stokke T; Jacobsen SE
Article: BLOOD. 1996;87(12):5016-5026

Ability of flt3 ligand to stimulate the in vitro growth of primitive murine hematopoietic progenitors is potently and directly inhibited by transforming growth factor-beta and tumor necrosis factor-alpha.

Jacobsen SE; Veiby OP; Myklebust J; Okkenhaug C; Lyman SD
Article: BLOOD. 1996;87(5):1728-1736

The RAR-RXR as well as the RXR-RXR pathway is involved in signaling growth inhibition of human CD34+ erythroid progenitor cells.

Rusten LS; Dybedal I; Blomhoff HK; Blomhoff R; Smeland EB; Jacobsen SE
Article: BLOOD. 1996;87(4):1317-1325

The FLT3 ligand is a direct and potent stimulator of the growth of primitive and committed human CD34+ bone marrow progenitor cells in vitro.

Rusten LS; Lyman SD; Veiby OP; Jacobsen SE
Article: STEM CELLS. 1996;14 Suppl 1:163-172

Megakaryocytopoiesis in vitro: from the stem cells' perspective.

Cardier JE; Foster DC; Lok S; Jacobsen SE; Murphy MJ
Article: BLOOD. 1995;86(8):2957-2966

Transforming growth factor-beta potently inhibits the viability-promoting activity of stem cell factor and other cytokines and induces apoptosis of primitive murine hematopoietic progenitor cells.

Jacobsen FW; Stokke T; Jacobsen SE
Article: RESEARCH IN IMMUNOLOGY. 1995;146(7-8):506-514

IL12, a direct stimulator and indirect inhibitor of haematopoiesis.

Jacobsen SE
Article: EXPERIMENTAL HEMATOLOGY. 1995;23(9):990-995

Direct synergistic effects of IL-4 and IL-11 on proliferation of primitive hematopoietic progenitor cells.

Jacobsen FW; Keller JR; Ruscetti FW; Veiby OP; Jacobsen SE
Article: BLOOD. 1995;86(3):949-957

Transforming growth factor beta (TGF-beta), a potent inhibitor of erythropoiesis: neutralizing TGF-beta antibodies show erythropoietin as a potent stimulator of murine burst-forming unit erythroid colony formation in the absence of a burst-promoting activity.

Dybedal I; Jacobsen SE
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 1995;7(1):45-50

Retinoic Acid potently stimulates the production of granulocyte-colony-stimulating factor in the human monocytic thp-1 cell-line.

Wang Y; Garg M; Guan F; Dai W; Jacobsen S; Murphy M
Article: JOURNAL OF IMMUNOLOGY. 1995;155(1):58-65

All-trans- and 9-cis-retinoic acid inhibit growth of normal human and murine B cell precursors.

Fahlman C; Jacobsen SE; Smeland EB; Lømo J; Naess CE; Funderud S; Blomhoff HK
Article: JOURNAL OF IMMUNOLOGY. 1995;154(10):4950-4955

IL-12 directly enhances in vitro murine erythropoiesis in combination with IL-4 and stem cell factor.

Dybedal I; Larsen S; Jacobsen SE
Article: JOURNAL OF IMMUNOLOGY. 1995;154(8):3732-3741

Inhibition of stem cell factor-induced proliferation of primitive murine hematopoietic progenitor cells signaled through the 75-kilodalton tumor necrosis factor receptor. Regulation of c-kit and p53 expression.

Jacobsen FW; Dubois CM; Rusten LS; Veiby OP; Jacobsen SE
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 1995;181(4):1357-1363

The FLT3 ligand potently and directly stimulates the growth and expansion of primitive murine bone marrow progenitor cells in vitro: synergistic interactions with interleukin (IL) 11, IL-12, and other hematopoietic growth factors.

Jacobsen SE; Okkenhaug C; Myklebust J; Veiby OP; Lyman SD
Article: BLOOD. 1995;85(4):989-996

Tumor necrosis factor (TNF)-alpha directly inhibits human erythropoiesis in vitro: role of p55 and p75 TNF receptors.

Rusten LS; Jacobsen SE
Visa fler

Alla övriga publikationer

Letter: CELL RESEARCH. 2023;33(11):883-886

Platelet and myeloid lineage biases of transplanted single perinatal mouse hematopoietic stem cells.

Belander Strålin K; Carrelha J; Winroth A; Ziegenhain C; Hagemann-Jensen M; Kettyle LM; Hillen A; Högstrand K; Markljung E; Grasso F; Seki M; Mazzi S; Meng Y; Wu B; Chari E; Lehander M; Sandberg R; Woll PS; Jacobsen SEW
Letter: BLOOD ADVANCES. 2022;6(16):4705-4709

The extent of residual WT HSPCs is associated with the degree of anemia in patients with SF3B1-mutated MDS-RS.

Hofman IJF; Mortera-Blanco T; Moura PL; Vestlund J; Larsson SV; Elvarsdottir EM; Walldin G; Tobiasson M; Sander B; Dimitriou M; Jacobsen S-EW; Woll PS; Jädersten M; Hellström-Lindberg E
Review: JOURNAL OF INTERNAL MEDICINE. 2022;292(2):262-277

Targeting stem cells in myelodysplastic syndromes and acute myeloid leukemia.

Woll PS; Yoshizato T; Hellström-Lindberg E; Fioretos T; Ebert BL; Jacobsen SEW
Corrigendum: CANCER CELL. 2014;25(6):861

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo (vol 25, pg 794, 2014)

Woll PS; Kjaellquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstroem-Lindberg E; Linnarsson S; Jacobsen SEW
Editorial comment: ONCOTARGET. 2013;4(6):814-815

Germline counterparts of oncogenic mutations: who gives a JAK?

Mead AJ; Constantinescu SN; Jacobsen SE
Corrigendum: NATURE CELL BIOLOGY. 2013;15(5):544

Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis (vol 15, pg 363, 2013)

Moignard V; Macaulay IC; Swiers G; Buettner F; Schuette J; Calero-Nieto FJ; Kinston S; Joshi A; Hannah R; Theis FJ; Jacobsen SE; de Bruijn MF; Goettgens B
Letter: LEUKEMIA. 2013;27(5):1204-1207

Quiescent leukaemic cells account for minimal residual disease in childhood lymphoblastic leukaemia.

Lutz C; Woll PS; Hall G; Castor A; Dreau H; Cazzaniga G; Zuna J; Jensen C; Clark SA; Biondi A; Mitchell C; Ferry H; Schuh A; Buckle V; Jacobsen S-EW; Enver T
Letter: NEW ENGLAND JOURNAL OF MEDICINE. 2012;366(10):967-969

Germline JAK2 mutation in a family with hereditary thrombocytosis.

Mead AJ; Rugless MJ; Jacobsen SEW; Schuh A
Editorial comment: CELL STEM CELL. 2011;8(3):242-244

Clever leukemic stem cells branch out.

Vyas P; Jacobsen SEW
Editorial comment: NATURE. 2009;461(7261):183-184

Developmental biology: Instructions writ in blood.

Enver T; Jacobsen SEW
Review: SEMINARS IN IMMUNOLOGY. 2008;20(4):213-220

Delineating the cellular pathways of hematopoietic lineage commitment.

Luc S; Buza-Vidas N; Jacobsen SEW
Letter: NATURE IMMUNOLOGY. 2007;8(9):897

TSLP-mediated fetal B lymphopoiesis?

Jensen CT; Kharazi S; Böiers C; Liuba K; Jacobsen SEW
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2007;1106:89-94

Biological and molecular evidence for existence of lymphoid-primed multipotent progenitors.

Luc S; Buza-Vidas N; Jacobsen SEW
Conference publication: BLOOD. 2007;110(11):661A

Downregulation of Mpl marks the transition to lymphoid-primed multipotent progenitors with gradual loss of granulocyte-monocyte potential

Luc S; Anderson K; Kharazi S; Buza-Vidas N; Boiers C; Jensen CT; Ma Z; Wittman L; Jacobsen SEW
Meeting abstract: BLOOD. 2006;108(11):109A

Distinct roles of integrins α6 and α4 in fetal liver hematopoietic stem and progenitor cell homing.

Qian H; Georges-Labouesse E; Nystrom A; Domogatskaya A; Tryggvason K; Eirik S; Jacobsen W; Ekblom M
Conference publication: BLOOD. 2006;108(11):29A

Enforced expression of GATA-2 confers quiescence on human hematopoietic stem and progenitor cells in in vitro and in vivo.

Tipping AJ; Pina C; Castor A; Atzberger A; Hong D; Lazzari L; May G; Jacobsen SE; Enver T
Editorial comment: NATURE IMMUNOLOGY. 2005;6(3):234-236

Defining 'stemness': Notch and Wnt join forces?

Jacobsen SEW
Review: BLOOD. 1998;91(4):1101-1134

c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities.

Lyman SD; Jacobsen SE
Review: STEM CELLS. 1996;14 Suppl 1:173-180

Thrombopoietin, a direct stimulator of viability and multilineage growth of primitive bone marrow progenitor cells.

Jacobsen SE; Borge OJ; Ramsfjell V; Cui L; Cardier JE; Veiby OP; Murphy MJ; Lok S
Other: JOURNAL OF EXPERIMENTAL MEDICINE. 1995;181(1):369-374

Mobilization of long-term reconstituting hematopoietic stem cells in mice by recombinant human interleukin 7.

Grzegorzewski KJ; Komschlies KL; Jacobsen SE; Ruscetti FW; Keller JR; Wiltrout RH

Forskningsbidrag

Role of Stem Cells in Normal and Malignant Hematopoiesis

Swedish Research Council

1 December 2023 - 30 November 2028
Characterization, Surveillance and Targeting of Cancer Stem Cells

Knut and Alice Wallenberg Foundation

1 January 2016 - 1 January 2021

Anställningar

Part-time Professor of Stem Cell Biology and Regenerative Medicine, Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, 2015-
Professor/Överläkare, Cell- och molekylärbiologi, Karolinska Institutet, 2014-
Professor/Överläkare, Medicin, Huddinge, Karolinska Institutet, 2014-