Sten Eirik Jacobsen

Om mig
Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Om mig

Sten Eirik Waelgaard Jacobsen, professor i stamcellsbiologi och regenerativ medicin vid institutionen för medicin i Huddinge och institutionen för cell- och molekylärbiologi, forskar om hur stamcellerna i benmärgen producerar blodceller. Forskningen handlar dels om den friska blodbildningen och hur den regleras, dels om orsakerna till olika blodsjukdomar, exempelvis leukemi.

Utvalda publikationer

Article: NATURE GENETICS. 2025;57(12):3088-3100
Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis
Yoshizato T; Nilsson C; Grasso F; Hogstrand K; Mazzi S; Winroth A; Lehander M; Barbosa I; Waldin G; Mortera-Blanco T; Jansson M; Widfeldt MH; Aliouat A; Brennan MS; Markljung E; Hillen A; Chari E; Hellstrom-Lindberg E; Kretzschmar WW; Woll PS; Jacobsen SEW
Review: NATURE REVIEWS CANCER. 2025;25(12):965-985
Targeting the roots of myeloid malignancies with T cell receptors
Foldvari Z; Brennan MS; Titov A; Jacobsen SEW; Olweus J
Article: NATURE IMMUNOLOGY. 2024;25(6):1007-1019
Alternative platelet differentiation pathways initiated by nonhierarchically related hematopoietic stem cells
Carrelha J; Mazzi S; Winroth A; Hagemann-Jensen M; Ziegenhain C; Hogstrand K; Seki M; Brennan MS; Lehander M; Wu B; Meng Y; Markljung E; Norfo R; Ishida H; Stralin KB; Grasso F; Karali CS; Aliouat A; Hillen A; Chari E; Siletti K; Thongjuea S; Mead AJ; Linnarsson S; Nerlov C; Sandberg R; Yoshizato T; Woll PS; Jacobsen SEW
Article: BLOOD. 2024;143(11):953-966
Identification and surveillance of rare relapse-initiating stem cells during complete remission after transplantation
Dimitriou M; Mortera-Blanco T; Tobiasson M; Mazzi S; Lehander M; Hoegstrand K; Karimi M; Walldin G; Jansson M; Vonlanthen S; Ljungman P; Langemeijer S; Yoshizato T; Hellstroem-Lindberg E; Woll PS; Jacobsen SEW
Article: NATURE CANCER. 2023;4(10):1474-1490
A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo
Giannakopoulou E; Lehander M; Virding Culleton S; Yang W; Li Y; Karpanen T; Yoshizato T; Rustad EH; Nielsen MM; Bollineni RC; Tran TT; Delic-Sarac M; Gjerdingen TJ; Douvlataniotis K; Laos M; Ali M; Hillen A; Mazzi S; Chin DWL; Mehta A; Holm JS; Bentzen AK; Bill M; Griffioen M; Gedde-Dahl T; Lehmann S; Jacobsen SEW; Woll PS; Olweus J
Article: NATURE BIOTECHNOLOGY. 2022;40(4):488-498
T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes
Ali M; Giannakopoulou E; Li Y; Lehander M; Culleton SV; Yang W; Knetter C; Odabasi MC; Bollineni RC; Yang X; Foldvari Z; Boschen M-L; Taraldsrud E; Stronen E; Toebes M; Hillen A; Mazzi S; de Ru AH; Janssen GMC; Kolstad A; Tjonnfjord GE; Lie BA; Griffioen M; Lehmann S; Osnes LT; Buechner J; Garcia KC; Schumacher TN; van Veelen PA; Leisegang M; Jacobsen SEW; Woll P; Olweus J
Article: CANCER CELL. 2018;33(2):274-291.e8
Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors
Booth CAG; Barkas N; Neo WH; Boukarabila H; Soilleux EJ; Giotopoulos G; Farnoud N; Giustacchini A; Ashley N; Carrelha J; Jamieson L; Atkinson D; Bouriez-Jones T; Prinjha RK; Milne TA; Teachey DT; Papaemmanuil E; Huntly BJP; Jacobsen SEW; Mead AJ
Article: NATURE. 2018;554(7690):106-111
Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells
Carrelha J; Meng Y; Kettyle LM; Luis TC; Norfo R; Alcolea V; Boukarabila H; Grasso F; Gambardella A; Grover A; Hogstrand K; Lord AM; Sanjuan-Pla A; Woll PS; Nerlov C; Jacobsen SEW
Article: NATURE MEDICINE. 2017;23(6):692-702
Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia
Giustacchini A; Thongjuea S; Barkas N; Woll PS; Povinelli BJ; Booth CAG; Sopp P; Norfo R; Rodriguez-Meira A; Ashley N; Jamieson L; Vyas P; Anderson K; Segerstolpe A; Qian H; Olsson-Stromberg U; Mustjoki S; Sandberg R; Jacobsen SEW; Mead AJ
Article: NATURE IMMUNOLOGY. 2016;17(12):1424-1435
Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors
Luis TC; Luc S; Mizukami T; Boukarabila H; Thongjuea S; Woll PS; Azzoni E; Giustacchini A; Lutteropp M; Bouriez-Jones T; Vaidya H; Mead AJ; Atkinson D; Boiers C; Carrelha J; Macaulay IC; Patient R; Geissmann F; Nerlov C; Sandberg R; de Bruijn MFTR; Blackburn CC; Godin I; Jacobsen SEW
Article: NATURE IMMUNOLOGY. 2016;17(6):666-676
Distinct myeloid progenitor-differentiation pathways identified through single-cell RNA sequencing
Drissen R; Buza-Vidas N; Woll P; Thongjuea S; Gambardella A; Giustacchini A; Mancini E; Zriwil A; Lutteropp M; Grover A; Mead A; Sitnicka E; Jacobsen SEW; Nerlov C
Article: CANCER CELL. 2014;25(6):794-808
Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo
Woll PS; Kjallquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstrom-Lindberg E; Linnarsson S; Jacobsen SEW
Article: CELL STEM CELL. 2013;13(5):535-548
Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells
Boiers C; Carrelha J; Lutteropp M; Luc S; Green JCA; Azzoni E; Woll PS; Mead AJ; Hultquist A; Swiers G; Perdiguero EG; Macaulay IC; Melchiori L; Luis TC; Kharazi S; Bouriez-Jones T; Deng Q; Ponten A; Atkinson D; Jensen CT; Sitnicka E; Geissmann F; Godin I; Sandberg R; de Bruijn MFTR; Jacobsen SEW
Article: NATURE. 2013;502(7470):232-236
Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy
Sanjuan-Pla A; Macaulay IC; Jensen CT; Woll PS; Luis TC; Mead A; Moore S; Carella C; Matsuoka S; Jones TB; Chowdhury O; Stenson L; Lutteropp M; Green JCA; Facchini R; Boukarabila H; Grover A; Gambardella A; Thongjuea S; Carrelha J; Tarrant P; Atkinson D; Clark S-A; Nerlov C; Jacobsen SEW
Article: NEW ENGLAND JOURNAL OF MEDICINE. 2010;363(11):1025-1037
Persistent Malignant Stem Cells in del(5q) Myelodysplasia in Remission
Tehranchi R; Woll PS; Anderson K; Buza-Vidas N; Mizukami T; Mead AJ; Astrand-Grundstrom I; Strombeck B; Horvat A; Ferry H; Dhanda RS; Hast R; Ryden T; Vyas P; Gohring G; Schlegelberger B; Johansson B; Hellstrom-Lindberg E; List A; Nilsson L; Jacobsen SEW
Article: IMMUNITY. 2007;26(4):407-419
Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors
Mansson R; Hultquist A; Luc S; Yang L; Anderson K; Kharazi S; Al-Hashmi S; Liuba K; Thoren L; Adolfsson J; Buza-Vidas N; Qian H; Soneji S; Enver T; Sigvardsson M; Jacobsen SEW
Article: NATURE MEDICINE. 2005;11(6):630-637
Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia
Castor A; Nilsson L; Åstrand-Grundström I; Buitenhuis M; Ramirez C; Anderson K; Strömbeck B; Garwicz S; Békássy AN; Schmiegelow K; Lausen B; Hokland P; Lehmann S; Juliusson G; Johansson B; Jacobsen SEW
Article: CELL. 2005;121(2):295-306
Identification of Flt3⁺ lympho-myeloid stem cells lacking erythro-megakaryocytic potential: A revised road map for adult blood lineage commitment
Adolfsson J; Månsson R; Buza-Vidas N; Hultquist A; Liuba K; Jensen CT; Bryder D; Yang LP; Borge OJ; Thoren LAM; Anderson K; Sitnicka E; Sasaki Y; Sigvardsson M; Jacobsen SEW

Artiklar

Journal article: NATURE CARDIOVASCULAR RESEARCH. 2025;4(12):1642-1661
Single-cell profiling reveals three endothelial-to-hematopoietic transitions with divergent isoform expression landscapes
Neo WH; Fadlullah MZH; Bhatnagar H; Barone C; Quattrini G; Timoteo-Ferreira F; Carrelha J; Sala G; Sellers R; Weightman J; Breitwieser W; Moncaut N; Thambyrajah R; Jacobsen SEW; Iqbal M; Baker SM; Azzoni E; Lie-A-Ling M; Lacaud G
Article: NATURE CARDIOVASCULAR RESEARCH. 2025;4(12):1642-1661
Single-cell profiling reveals three endothelial-to-hematopoietic transitions with divergent isoform expression landscapes.
Neo WH; Fadlullah MZH; Bhatnagar H; Barone C; Quattrini G; Timóteo-Ferreira F; Carrelha J; Sala G; Sellers R; Weightman J; Breitwieser W; Moncaut N; Thambyrajah R; Jacobsen SEW; Iqbal M; Baker SM; Azzoni E; Lie-A-Ling M; Lacaud G
Article: SCIENTIFIC REPORTS. 2025;15(1):42018
Complex genotype-phenotype relationships shape the response to treatment of down syndrome childhood acute lymphoblastic leukaemia
Lutz C; Turati VA; Clifford R; Woll PS; Stiehl T; Castor A; Clark SA; Ferry H; Buckle V; Trumpp A; Ho A; Marciniak-Czochra A; Herrero J; Schuh A; Jacobsen SEW; Enver T
Journal article: ANNALS OF INTERNAL MEDICINE. 2025;178(2):300-304
Germline UBA1 Variant With Somatic Amplification in a Woman With Inflammatory Diseases and Myelodysplastic Syndrome.
Creignou M; Sirenko M; Moura PL; Mortera-Blanco T; Dimitriou M; Sander B; Domenico D; Arango Ossa JE; Tesi B; Beck DB; Woll P; Jacobsen S-EW; Papaemmanuil E; Bernard E; Hellström-Lindberg E
Article: BLOOD NEOPLASIA. 2024;1(2):100011
Competition of dual SF3B1 mt clones in MDS-RS is associated with distinct RNA mis-splicing in hematopoietic stem cells.
Moura PL; Nannya Y; Aliouat A; Hofman IJ; Mortera-Blanco T; Yoshizato T; Saiki R; Nakagawa MM; Creignou M; Björklund A-C; Walldin G; Barbosa I; Jansson M; Grasso F; Elvarsdottir EM; Woll PS; Jacobsen SEW; Ogawa S; Hellström-Lindberg E
Article: JOURNAL OF CLINICAL ONCOLOGY. 2024;42(12):1378-1390
Patient-Specific Measurable Residual Disease Markers Predict Outcome in Patients With Myelodysplastic Syndrome and Related Diseases After Hematopoietic Stem-Cell Transplantation
Tobiasson M; Pandzic T; Illman J; Nilsson L; Westrom S; Ejerblad E; Olesen G; Bjorklund A; Olsnes Kittang A; Werlenius O; Lorentz F; Rasmussen B; Cammenga J; Weber D; Lindholm C; Wiggh J; Dimitriou M; Moen AE; Lundstrom LY; von Bahr L; Baltzer-Sollander K; Jadersten M; Kytola S; Walldin G; Ljungman P; Groenbaek K; Mielke S; Jacobsen SEW; Ebeling F; Cavelier L; Smidstrup Friis L; Dybedal I; Hellstrom-Lindberg E
Article: CANCER RESEARCH. 2024;84(2):211-225
Erythroid Differentiation Enhances RNA Mis-Splicing in SF3B1-Mutant Myelodysplastic Syndromes with Ring Sideroblasts
Moura PL; Mortera-Blanco T; Hofman IJ; Todisco G; Kretzschmar WW; Bjoerklund A-C; Creignou M; Hagemann-Jensen M; Ziegenhain C; Cabrerizo Granados D; Barbosa I; Walldin G; Jansson M; Ashley N; Mead AJ; Lundin V; Dimitriou M; Yoshizato T; Woll PS; Ogawa S; Sandberg R; Jacobsen SEW; Hellstrom-Lindberg E
Article: AUTOPHAGY. 2024;20(1):45-57
Autophagy preserves hematopoietic stem cells by restraining MTORC1-mediated cellular anabolism
Borsa M; Obba S; Richter FC; Zhang H; Riffelmacher T; Carrelha J; Alsaleh G; Jacobsen SEW; Simon AK
Article: BLOOD. 2023;142(19):1622-1632
Loss of endothelial membrane KIT ligand affects systemic KIT ligand levels but not bone marrow hematopoietic stem cells
Matsuoka S; Facchini R; Luis TC; Carrelha J; Woll PS; Mizukami T; Wu B; Boukarabila H; Buono M; Norfo R; Arai F; Suda T; Mead AJ; Nerlov C; Jacobsen SEW
Article: CLINICAL CANCER RESEARCH. 2023;29(20):4256-4267
Integrated Genomic and Transcriptomic Analysis Improves Disease Classification and Risk Stratification of MDS with Ring Sideroblasts
Todisco G; Creignou M; Bernard E; Bjorklund A-C; Moura PL; Tesi B; Mortera-Blanco T; Sander B; Jansson M; Walldin G; Barbosa I; Reinsbach SE; Hofman IJ; Nilsson C; Yoshizato T; Dimitriou M; Chang D; Olafsdottir S; Larsson SV; Tobiasson M; Malcovati L; Woll P; Jacobsen SEW; Papaemmanuil E; Hellstroem-Lindberg E
Article: NATURE COMMUNICATIONS. 2023;14(1):6062
Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner
Luis TC; Barkas N; Carrelha J; Giustacchini A; Mazzi S; Norfo R; Wu B; Aliouat A; Guerrero JA; Rodriguez-Meira A; Bouriez-Jones T; Macaulay IC; Jasztal M; Zhu G; Ni H; Robson MJ; Blakely RD; Mead AJ; Nerlov C; Ghevaert C; Jacobsen SEW
Article: NATURE GENETICS. 2023;55(9):1531-1541
Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution
Rodriguez-Meira A; Norfo R; Wen S; Chedeville AL; Rahman H; O'Sullivan J; Wang G; Louka E; Kretzschmar WW; Paterson A; Brierley C; Martin J-E; Demeule C; Bashton M; Sousos N; Moralli D; Meem LS; Carrelha J; Wu B; Hamblin A; Guermouche H; Pasquier F; Marzac C; Girodon F; Vainchenker W; Drummond M; Harrison C; Chapman JR; Plo I; Jacobsen SEW; Psaila B; Thongjuea S; Antony-Debre I; Mead AJ
Article: GENOME BIOLOGY. 2023;24(1):152
Panhematopoietic RNA barcoding enables kinetic measurements of nucleate and anucleate lineages and the activation of myeloid clones following acute platelet depletion
Wojtowicz EE; Mistry JJ; Uzun V; Hellmich C; Scoones A; Chin DW; Kettyle LM; Grasso F; Lord AM; Wright DJ; Etherington GJ; Woll PS; Belderbos ME; Bowles KM; Nerlov C; Haerty W; Bystrykh LV; Jacobsen SEW; Rushworth SA; Macaulay IC
Article: NATURE CELL BIOLOGY. 2023;25(6):812-822
Epigenetic programming defines haematopoietic stem cell fate restriction
Meng Y; Carrelha J; Drissen R; Ren X; Zhang B; Gambardella A; Valletta S; Thongjuea S; Jacobsen SE; Nerlov C
Article: BLOOD. 2022;139(4):629-634
Aged healthy mice acquire clonal hematopoiesis mutations
Chin DWL; Yoshizato T; Culleton SV; Grasso F; Barbachowska M; Ogawa S; Jacobsen SEW; Woll PS
Article: JOURNAL OF IMMUNOLOGY. 2022;208(2):358-370
DNMT1 Deficiency Impacts on Plasmacytoid Dendritic Cells in Homeostasis and Autoimmune Disease
Czeh M; Stable S; Kramer S; Tepe L; Talyan S; Carrelha J; Meng Y; Heitplatz B; Schwabenland M; Milsom MD; Plass C; Prinz M; Schlesner M; Andrade-Navarro MA; Nerlov C; Jacobsen SEW; Lipka DB; Rosenbauer F
Article: CELL REPORTS. 2021;37(11):110103
The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition
Azzoni E; Frontera V; Anselmi G; Rode C; James C; Deltcheva EM; Demian AS; Brown J; Barone C; Patelli A; Harman JR; Nicholls M; Conway SJ; Morrissey E; Jacobsen SEW; Sparrow DB; Harris AL; Enver T; de Bruijn MFTR
Article: NATURE COMMUNICATIONS. 2021;12(1):7019
Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors
Neo WH; Meng Y; Rodriguez-Meira A; Fadlullah MZH; Booth CAG; Azzoni E; Thongjuea S; de Bruijn MFTR; Jacobsen SEW; Mead AJ; Lacaud G
Journal article: BLOOD. 2021;138:146
Integrative Analysis of Primary SF3B1 ^mt Ring Sideroblasts Provides Fundamental Insights into MDS-RS Pathogenesis and Dyserythropoiesis
Moura PL; Mortera-Blanco T; Hofman IJF; Todisco G; Kretzschmar WW; Barbosa I; Bjorklund A-C; Walldin G; Jansson M; Yoshizato T; Woll PS; Jacobsen SEW; Lindberg EH
Article: NATURE CANCER. 2021;2(8):835-852
Chemotherapy induces canalization of cell state in childhood B-cell precursor acute lymphoblastic leukemia
Turati VA; Guerra-Assuncao JA; Potter NE; Gupta R; Ecker S; Daneviciute A; Tarabichi M; Webster AP; Ding C; May G; James C; Brown J; Conde L; Russell LJ; Ancliff P; Inglott S; Cazzaniga G; Biondi A; Hall GW; Lynch M; Hubank M; Macaulay I; Beck S; Van Loo P; Jacobsen SE; Greaves M; Herrero J; Enver T
Article: JOURNAL OF INTERNAL MEDICINE. 2021;289(5):650-661
Stem cell concepts in myelodysplastic syndromes: lessons and challenges
Woll PS; Jacobsen SEW
Article: DEVELOPMENT. 2021;148(3):dev194563
Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart
Cahill TJ; Sun X; Ravaud C; Villa del Campo C; Klaourakis K; Lupu I-E; Lord AM; Browne C; Jacobsen SEW; Greaves DR; Jackson DG; Cowley SA; James W; Choudhury RP; Miguel Vieira J; Riley PR
Article: NATURE COMMUNICATIONS. 2021;12(1):464
Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice
Papaioannou NE; Salei N; Rambichler S; Ravi K; Popovic J; Kuentzel V; Lehmann CHK; Fiancette R; Salvermoser J; Gajdasik DW; Mettler R; Messerer D; Carrelha J; Ohnmacht C; Haller D; Stumm R; Straub T; Jacobsen SEW; Schulz C; Withers DR; Schotta G; Dudziak D; Schraml BU
Journal article: BLOOD. 2020;136:5-6
Prediction of Relapse after Allogeneic Stem Cell Transplantation Using Individualized Minimal Residual Markers; The Prospective Nordic Study NMDSG14B
Tobiasson M; Pandzic T; Illman J; Nilsson L; Westrom S; Olsson D; Ejerblad E; Kittang AO; Olesen G; Werlenius O; Bjorklund AT; Lorentz F; Rasmussen BEH; Cammenga J; Weber D; Dimitriou M; Kytola S; Walldin G; Groenbaek K; Mielke S; Jacobsen SEW; Ebeling F; Cavelier L; Friis LS; Dybedal I; Lindberg EH
Article: JOURNAL OF TRANSLATIONAL AUTOIMMUNITY. 2020;3:100066
cDC1 are required for the initiation of collagen-induced arthritis
Ramos MI; Garcia S; Helder B; Aarrass S; Reedquist KA; Jacobsen SE; Tak PP; Lebre MC
Article: MOLECULAR CELL. 2019;73(6):1292-1305.e8
Unravelling Intratumoral Heterogeneity through High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA Sequencing
Rodriguez-Meira A; Buck G; Clark S-A; Povinelli BJ; Alcolea V; Louka E; McGowan S; Hamblin A; Sousos N; Barkas N; Giustacchini A; Psaila B; Jacobsen SEW; Thongjuea S; Mead AJ
Article: NATURE CELL BIOLOGY. 2019;21(1):2-8
Haematopoiesis in the era of advanced single-cell technologies
Jacobsen SEW; Nerlov C
Article: JOURNAL OF IMMUNOLOGY. 2018;201(11):3307-3319
Loss of Canonical Notch Signaling Affects Multiple Steps in NK Cell Development in Mice
Chaves P; Zriwil A; Wittmann L; Boukarabila H; Peitzsch C; Jacobsen SEW; Sitnicka E
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2018;183(4):588-600
Direct role of FLT3 in regulation of early lymphoid progenitors
Zriwil A; Boeiers C; Kristiansen TA; Wittmann L; Yuan J; Nerlov C; Sitnicka E; Jacobsen SEW
Article: EMBO REPORTS. 2018;19(10):e45477
Kit ligand has a critical role in mouse yolk sac and aorta-gonad-mesonephros hematopoiesis
Azzoni E; Frontera V; McGrath KE; Harman J; Carrelha J; Nerlov C; Palis J; Jacobsen SEW; de Bruijn MFTR
Article: ONCOSCIENCE. 2018;5(11-12):271-272
Origins of ETP leukemia.
Booth CAG; Jacobsen SEW; Mead AJ
Article: BLOOD. 2018;131(20):2223-2234
Cell-extrinsic hematopoietic impact of Ezh2 inactivation in fetal liver endothelial cells
Neo WH; Booth CAG; Azzoni E; Chi L; Delgado-Olguin P; de Bruijn MFTR; Jacobsen SEW; Mead AJ
Article: BLOOD. 2018;131(15):1712-1719
Canonical Notch signaling is dispensable for adult steady-state and stress myelo-erythropoiesis
Duarte S; Woll PS; Buza-Vidas N; Chin DWL; Boukarabila H; Luis TC; Stenson L; Bouriez-Jones T; Ferry H; Mead AJ; Atkinson D; Jin S; Clark S-A; Wu B; Repapi E; Gray N; Taylor S; Mutvei AP; Tsoi YL; Nerlov C; Lendahl U; Jacobsen SEW
Article: DEVELOPMENTAL CELL. 2018;44(3):362-377.e7
A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1
Boiers C; Richardson SE; Laycock E; Zriwil A; Turati VA; Brown J; Wray JP; Wang D; James C; Herrero J; Sitnicka E; Karlsson S; Smith AJH; Jacobsen SEW; Enver T
Article: CELL STEM CELL. 2018;22(2):262-276.e7
In Vivo Labeling by CD73 Marks Multipotent Stromal Cells and Highlights Endothelial Heterogeneity in the Bone Marrow Niche
Breitbach M; Kimura K; Luis TC; Fuegemann CJ; Woll PS; Hesse M; Facchini R; Rieck S; Jobin K; Reinhardt J; Ohneda O; Wenzel D; Geisen C; Kurts C; Kastenmueller W; Hoelzel M; Jacobsen SEW; Fleischmann BK
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2017;214(10):3085-3104
Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program
Loughran SJ; Comoglio F; Hamey FK; Giustacchini A; Errami Y; Earp E; Gottgens B; Jacobsen SEW; Mead AJ; Hendrich B; Green AR
Article: IMMUNITY. 2017;47(3):466-480.e5
Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation
Riffelmacher T; Clarke A; Richter FC; Stranks A; Pandey S; Danielli S; Hublitz P; Yu Z; Johnson E; Schwerd T; McCullagh J; Uhlig H; Jacobsen SEW; Simon AK
Article: BLOOD. 2017;130(7):881-890
SF3B1-initiating mutations in MDS-RSs target lymphomyeloid hematopoietic stem cells
Mortera-Blanco T; Dimitriou M; Woll PS; Karimi M; Elvarsdottir E; Conte S; Tobiasson M; Jansson M; Douagi I; Moarii M; Saft L; Papaemmanuil E; Jacobsen SEW; Hellstrom-Lindberg E
Article: CELL REPORTS. 2017;20(3):572-585
Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes
Unnikrishnan A; Papaemmanuil E; Beck D; Deshpande NP; Verma A; Kumari A; Woll PS; Richards LA; Knezevic K; Chandrakanthan V; Thoms JAI; Tursky ML; Huang Y; Ali Z; Olivier J; Galbraith S; Kulasekararaj AG; Tobiasson M; Karimi M; Pellagatti A; Wilson SR; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen SEW; Mufti GJ; Hellstrom-Lindberg E; Wilkins MR; MacKenzie KL; Wong JWH; Campbell PJ; Pimanda JE
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2017;214(7):2005-2021
Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation
Mead AJ; Neo WH; Barkas N; Matsuoka S; Giustacchini A; Facchini R; Thongjuea S; Jamieson L; Booth CAG; Fordham N; Di Genua C; Atkinson D; Chowdhury O; Repapi E; Gray N; Kharazi S; Clark S-A; Bouriez T; Woll P; Suda T; Nerlov C; Jacobsen SEW
Article: HAEMATOLOGICA. 2017;102(3):498-508
Progression in patients with low- and intermediate-1-risk del(5q) myelodysplastic syndromes is predicted by a limited subset of mutations
Scharenberg C; Giai V; Pellagatti A; Saft L; Dimitriou M; Jansson M; Jadersten M; Grandien A; Douagi I; Neuberg DS; LeBlanc K; Boultwood J; Karimi M; Jacobsen SEW; Woll PS; Hellstrom-Lindberg E
Journal article: BLOOD. 2016;128(22):4329
Progression in Patients with with Low- and Intermediate-1 Risk Del(5q) MDS Is Predicted By a Limited Subset of Mutations
Scharenberg C; Woll PS; Giai V; Pellagatti A; Saft L; Dimitriou M; Jädersten M; Jansson M; Douagi I; Neuberg DS; Karimi M; Le Blanc K; Boultwood J; Jacobsen SE; Hellstrom-Lindberg E
Journal article: BLOOD. 2016;128(22):606
Single-Cell Analysis of Clonal Dynamics in Childhood ALL Reveals a Key Role for Transcriptional Intratumor Heterogeneity in Driving Resistance to Chemotherapy
Turati VA; Guerra-Assuncao JA; Ambrose JC; Brown J; Hubank M; Hobbs A; Lynch M; Gaal B; Inglott S; Conde L; Richardson S; Herrero J; Jacobsen SE; Enver T
Article: ONCOTARGET. 2016;7(45):72685-72698
Perturbed hematopoietic stem and progenitor cell hierarchy in myelodysplastic syndromes patients with monosomy 7 as the sole cytogenetic abnormality
Dimitriou M; Woll PS; Mortera-Blanco T; Karimi M; Wedge DC; Doolittle H; Douagi I; Papaemmanuil E; Jacobsen SEW; Hellstrom-Lindberg E
Article: CELL REPORTS. 2016;16(4):1039-1054
Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development
Barrett NA; Malouf C; Kapeni C; Bacon WA; Giotopoulos G; Jacobsen SEW; Huntly BJ; Ottersbach K
Article: BLOOD. 2016;128(2):217-226
Macrophage colony-stimulating factor receptor marks and regulates a fetal myeloid-primed B-cell progenitor in mice
Zriwil A; Boiers C; Wittmann L; Green JCA; Woll PS; Jacobsen SEW; Sitnicka E
Article: CIRCULATION RESEARCH. 2016;118(10):1498-1511
Primitive Embryonic Macrophages are Required for Coronary Development and Maturation
Leid J; Carrelha J; Boukarabila H; Epelman S; Jacobsen SEW; Lavine KJ
Article: NATURE COMMUNICATIONS. 2016;7:11075
Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells
Grover A; Sanjuan-Pla A; Thongjuea S; Carrelha J; Giustacchini A; Gambardella A; Macaulay I; Mancini E; Luis TC; Mead A; Jacobsen SEW; Nerlov C
Article: NATURE CELL BIOLOGY. 2016;18(2):157-167
A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors
Buono M; Facchini R; Matsuoka S; Thongjuea S; Waithe D; Luis TC; Giustacchini A; Besmer P; Mead AJ; Jacobsen SEW; Nerlov C
Journal article: BLOOD. 2015;126(23):846
Ezh2 and Runx1 Mutations Targeted to Early Lymphoid Progenitors Collaborate to Promote Early Thymic Progenitor Leukemia
Booth C; Barkas N; Neo WH; Soilleux E; Boukarabila H; Giustacchini A; Milne T; Ashley N; Carrelha J; Jamieson L; Atkinson D; Bouriez-Jones T; Jacobsen SE; Mead A
Journal article: BLOOD. 2015;126(23):13
Single Cell Whole Transcriptome Analysis Reveals Distinct Molecular Signatures of Therapy-Resistant Chronic Myeloid Leukemia Stem Cells
Giustacchini A; Thongjuea S; Woll PS; Sopp P; Perez AD; Barkas N; Booth C; Norfo R; Clark S-A; Jamieson L; Jacobsen SE; Mead A
Article: CELL DEATH DISCOVERY. 2015;1:15008
Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia
Watson AS; Riffelmacher T; Stranks A; Williams O; De Boer J; Cain K; Macfarlane M; Mcgouran J; Kessler B; Khandwala S; Chowdhury O; Puleston D; Phadwal K; Mortensen M; Ferguson D; Soilleux E; Woll P; Jacobsen SEW; Simon AK
Article: NATURE COMMUNICATIONS. 2015;6:6930
PDGFRα demarcates the cardiogenic clonogenic Sca1⁺ stem/progenitor cell in adult murine myocardium
Noseda M; Harada M; McSweeney S; Leja T; Belian E; Stuckey DJ; Paiva MSA; Habib J; Macaulay I; de Smith AJ; al-Beidh F; Sampson R; Lumbers RT; Rao P; Harding SE; Blakemore AIF; Jacobsen SE; Barahona M; Schneider MD
Article: ANNALS OF THE RHEUMATIC DISEASES. 2015;74(1):211-219
Absence of Fms-like tyrosine kinase 3 ligand (Flt3L) signalling protects against collagen-induced arthritis
Ramos MIP; Karpus ON; Broekstra P; Aarrass S; Jacobsen SE; Tak PP; Lebre MC
Article: LEUKEMIA. 2015;29(1):38-50
Clonal variegation and dynamic competition of leukemia-initiating cells in infant acute lymphoblastic leukemia with MLL rearrangement
Bardini M; Woll PS; Corral L; Luc S; Wittmann L; Ma Z; Lo Nigro L; Basso G; Biondi A; Cazzaniga G; Jacobsen SEW
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2014;93(5):439-445
A pilot phase I dose finding safety study of the thrombopoietin-receptor agonist, eltrombopag, in patients with myelodysplastic syndrome treated with azacitidine
Svensson T; Chowdhury O; Garelius H; Lorenz F; Saft L; Jacobsen S-E; Hellstrom-Lindberg E; Cherif H
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2014;211(2):181-188
Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate
Grover A; Mancini E; Moore S; Mead AJ; Atkinson D; Rasmussen KD; O'Carroll D; Jacobsen SEW; Nerlov C
Journal article: BLOOD. 2013;122(21):2749
Hierarchical Analysis Of Recurrent Point Mutations In SF3B1 and TET2 In RARS Stem Cells
Mortera-Blanco T; Dimitriou M; Woll P; Karimi M; Papaemmanuil E; Conte S; Chowdhuri O; Jansson M; Campbell PJ; Jacobsen SEW; Hellstroem-Lindberg E
Article: CELL REPORTS. 2013;3(6):1766-1776
FLT3-ITDs Instruct a Myeloid Differentiation and Transformation Bias in Lymphomyeloid Multipotent Progenitors
Mead AJ; Kharazi S; Atkinson D; Macaulay I; Pecquet C; Loughran S; Lutteropp M; Woll P; Chowdhury O; Luc S; Buza-Vidas N; Ferry H; Clark S-A; Goardon N; Vyas P; Constantinescu SN; Sitnicka E; Nerlov C; Jacobsen SEW
Article: IMMUNITY. 2013;38(5):930-942
Transcriptional Repression of Gata3 Is Essential for Early B Cell Commitment
Banerjee A; Northrup D; Boukarabila H; Jacobsen SEW; Allman D
Article: BLOOD. 2013;121(20):4156-4165
Impact of isolated germline JAK2V617I mutation on human hematopoiesis
Mead AJ; Chowdhury O; Pecquet C; Dusa A; Woll P; Atkinson D; Burns A; Score J; Rugless M; Clifford R; Moule S; Bienz N; Vyas P; Cross N; Gale RE; Henderson S; Constantinescu SN; Schuh A; Jacobsen SEW
Article: NATURE CELL BIOLOGY. 2013;15(4):363-372
Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis
Moignard V; Macaulay IC; Swiers G; Buettner F; Schuette J; Calero-Nieto FJ; Kinston S; Joshi A; Hannah R; Theis FJ; Jacobsen SE; de Bruijn MF; Goettgens B
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2013;160(6):842-850
Silencing of ASXL1 impairs the granulomonocytic lineage potential of human CD34⁺ progenitor cells
Davies C; Yip BH; Fernandez-Mercado M; Woll PS; Agirre X; Prosper F; Jacobsen SE; Wainscoat JS; Pellagatti A; Boultwood J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(43):17579-17584
Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21
Roy A; Cowan G; Mead AJ; Filippi S; Bohn G; Chaidos A; Tunstall O; Chan JKY; Choolani M; Bennett P; Kumar S; Atkinson D; Wyatt-Ashmead J; Hu M; Stumpf MPH; Goudevenou K; O'Connor D; Chou ST; Weiss MJ; Karadimitris A; Jacobsen SE; Vyas P; Roberts I
Article: BLOOD. 2012;120(12):2412-2416
Dicer is selectively important for the earliest stages of erythroid development
Buza-Vidas N; Cismasiu VB; Moore S; Mead AJ; Woll PS; Lutteropp M; Melchiori L; Luc S; Bouriez-Jones T; Atkinson D; O'Carroll D; Jacobsen SEW; Nerlov C
Article: BLOOD. 2012;120(1):63-75
Emergence of NK-cell progenitors and functionally competent NK-cell lineage subsets in the early mouse embryo
Tang Y; Peitzsch C; Charoudeh HN; Cheng M; Chaves P; Jacobsen SEW; Sitnicka E
Article: LEUKEMIA. 2012;26(7):1527-1536
Molecular and cellular effects of oncogene cooperation in a genetically accurate AML mouse model
Reckzeh K; Bereshchenko O; Mead A; Rehn M; Kharazi S; Jacobsen S-E; Nerlov C; Cammenga J
Article: JOURNAL OF NEUROSCIENCE. 2012;32(15):5151-5164
Adaptor Protein LNK Is a Negative Regulator of Brain Neural Stem Cell Proliferation after Stroke
Ahlenius H; Devaraju K; Monni E; Oki K; Wattananit S; Darsalia V; Iosif RE; Torper O; Wood JC; Braun S; Jagemann L; Nuber UA; Englund E; Jacobsen S-EW; Lindvall O; Kokaia Z
Article: SCIENCE. 2012;336(6077):86-90
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz C; Perdiguero EG; Chorro L; Szabo-Rogers H; Cagnard N; Kierdorf K; Prinz M; Wu B; Jacobsen SEW; Pollard JW; Frampton J; Liu KJ; Geissmann F
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2012;209(3):537-549
Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow
Mansour A; Abou-Ezzi G; Sitnicka E; Jacobsen SEW; Wakkach A; Blin-Wakkach C
Article: NATURE IMMUNOLOGY. 2012;13(4):412-419
The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential
Luc S; Luis TC; Boukarabila H; Macaulay IC; Buza-Vidas N; Bouriez-Jones T; Lutteropp M; Won PS; Loughran SJ; Mead AJ; Hultquist A; Brown J; Mizukami T; Matsuoka S; Ferry H; Anderson K; Duarte S; Atkinson D; Soneji S; Domanski A; Farley A; Sanjuan-Pla A; Carella C; Patient R; de Bruijn M; Enver T; Nerlov C; Blackburn C; Godin I; Jacobsen SEW
Article: EMBO JOURNAL. 2012;31(2):351-365
FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors
Mancini E; Sanjuan-Pla A; Luciani L; Moore S; Grover A; Zay A; Rasmussen KD; Luc S; Bilbao D; O'Carroll D; Jacobsen SE; Nerlov C
Article: PLOS GENETICS. 2011;7(12):e1002404
Acute Multiple Organ Failure in Adult Mice Deleted for the Developmental Regulator Wt1
Chau Y-Y; Brownstein D; Mjoseng H; Lee W-C; Buza-Vidas N; Nerlov C; Jacobsen SE; Perry P; Berry R; Thornburn A; Sexton D; Morton N; Hohenstein P; Freyer E; Samuel K; van't Hof R; Hastie N
Article: BLOOD. 2011;118(13):3613-3621
Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation
Kharazi S; Mead AJ; Mansour A; Hultquist A; Boiers C; Luc S; Buza-Vidas N; Ma Z; Ferry H; Atkinson D; Reckzeh K; Masson K; Cammenga J; Ronnstrand L; Arai F; Suda T; Nerlov C; Sitnicka E; Jacobsen SEW
Article: BLOOD. 2011;118(6):1544-1548
FLT3 expression initiates in fully multipotent mouse hematopoietic progenitor cells
Buza-Vidas N; Woll P; Hultquist A; Duarte S; Lutteropp M; Bouriez-Jones T; Ferry H; Luc S; Jacobsen SEW
Article: BLOOD. 2011;118(5):1291-1293
GATA3 is redundant for maintenance and self-renewal of hematopoietic stem cells
Buza-Vidas N; Duarte S; Luc S; Bouriez-Jones T; Woll PS; Jacobsen SEW
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2011;208(8):1563-1570
Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors
Pronk CJH; Veiby OP; Bryder D; Jacobsen SEW
Article: EPIGENETICS & CHROMATIN. 2011;4(1):9
Generation of bivalent chromatin domains during cell fate decisions
De Gobbi M; Garrick D; Lynch M; Vernimmen D; Hughes JR; Goardon N; Luc S; Lower KM; Sloane-Stanley JA; Pina C; Soneji S; Renella R; Enver T; Taylor S; Jacobsen SEW; Vyas P; Gibbons RJ; Higgs DR
Article: BLOOD. 2011;117(13):3521-3528
Hoxb4-YFP reporter mouse model: a novel tool for tracking HSC development and studying the role of Hoxb4 in hematopoiesis
Hills D; Gribi R; Ure J; Buza-Vidas N; Luc S; Jacobsen SEW; Medvinsky A
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2011;208(3):455-467
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance
Mortensen M; Soilleux EJ; Djordjevic G; Tripp R; Lutteropp M; Sadighi-Akha E; Stranks AJ; Glanville J; Knight S; Jacobsen S-EW; Kranc KR; Simon AK
Article: CANCER CELL. 2011;19(1):138-152
Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia
Goardon N; Marchi E; Atzberger A; Quek L; Schuh A; Soneji S; Woll P; Mead A; Alford KA; Rout R; Chaudhury S; Gilkes A; Knapper S; Beldjord K; Begum S; Rose S; Geddes N; Griffiths M; Standen G; Sternberg A; Cavenagh J; Hunter H; Bowen D; Killick S; Robinson L; Price A; Macintyre E; Virgo P; Burnett A; Craddock C; Enver T; Jacobsen SEW; Porcher C; Vyas P
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2010;150(3):293-302
Maintenance treatment with azacytidine for patients with high-risk myelodysplastic syndromes (MDS) or acute myeloid leukaemia following MDS in complete remission after induction chemotherapy
Grovdal M; Karimi M; Khan R; Aggerholm A; Antunovic P; Astermark J; Bernell P; Engstrom L-M; Kjeldsen L; Linder O; Nilsson L; Olsson A; Holm MS; Tangen JM; Wallvik J; Oberg G; Hokland P; Jacobsen SE; Porwit A; Hellstrom-Lindberg E
Article: BLOOD. 2010;116(2):183-192
Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells
Charoudeh HN; Tang Y; Cheng M; Cilio CM; Jacobsen SEW; Sitnicka E
Article: BLOOD. 2010;115(24):5061-5068
Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development
Boiers C; Buza-Vidas N; Jensen CT; Pronk CJH; Kharazi S; Wittmann L; Sitnicka E; Hultquist A; Jacobsen SEW
Article: CELL STEM CELL. 2009;5(6):659-665
Cited2 Is an Essential Regulator of Adult Hematopoietic Stem Cells
Kranc KR; Schepers H; Rodrigues NP; Bamforth S; Villadsen E; Ferry H; Bouriez-Jones T; Sigvardsson M; Bhattacharya S; Jacobsen SE; Enver T
Article: CANCER CELL. 2009;16(5):390-400
Hematopoietic Stem Cell Expansion Precedes the Generation of Committed Myeloid Leukemia-initiating Cells in C/EBPα Mutant AML
Bereshchenko O; Mancini E; Moore S; Bilbao D; Mansson R; Luc S; Grover A; Jacobsen SEW; Bryder D; Nerlov C
Article: NATURE GENETICS. 2009;41(11):1207-1215
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction
Broeske A-M; Vockentanz L; Kharazi S; Huska MR; Mancini E; Scheller M; Kuhl C; Enns A; Prinz M; Jaenisch R; Nerlov C; Leutz A; Andrade-Navarro MA; Jacobsen SEW; Rosenbauer F
Article: GLIA. 2009;57(8):835-849
Long-Term Accumulation of Microglia with Proneurogenic Phenotype Concomitant with Persistent Neurogenesis in Adult Subventricular Zone After Stroke
Thored P; Heldmann U; Gomes-Leal W; Gisler R; Darsalia V; Taneera J; Nygren JM; Jacobsen S-EW; Ekdahl CT; Kokaia Z; Lindvall O
Article: BLOOD. 2009;113(19):4790-4798
Polyclonal T-cell reconstitution of X-SCID recipients after in utero transplantation of lymphoid-primed multipotent progenitors
Liuba K; Pronk CJH; Stott SRW; Jacobsen S-EW
Article: BLOOD. 2009;113(15):3453-3460
FLT3 receptor and ligand are dispensable for maintenance and posttransplantation expansion of mouse hematopoietic stem cells
Buza-Vidas N; Cheng M; Duarte S; Charoudeh HN; Jacobsen SEW; Sitnicka E
Article: BLOOD. 2009;113(12):2661-2672
High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle
Tipping AJ; Pina C; Castor A; Hong D; Rodrigues NP; Lazzari L; May GE; Jacobsen SEW; Enver T
Article: JOURNAL OF IMMUNOLOGY. 2009;182(3):1460-1468
Distinct and Overlapping Patterns of Cytokine Regulation of Thymic and Bone Marrow-Derived NK Cell Development
Cheng M; Charoudeh HN; Brodin P; Tang Y; Lakshmikanth T; Hoglund P; Jacobsen SEW; Sitnicka E
Article: CYTOTHERAPY. 2009;11(2):114-128
Characterization of bone marrow-derived mesenchymal stromal cells (MSC) based on gene expression profiling of functionally defined MSC subsets
Tormin A; Brune JC; Olsson E; Valcich J; Neuman U; Olofsson T; Jacobsen S-E; Scheding S
Article: BLOOD. 2008;112(6):2297-2304
FLT3 ligand and not TSLP is the key regulator of IL-7-independent B-1 and B-2 B lymphopoiesis
Jensen CT; Kharazi S; Boiers C; Cheng M; Lubking A; Sitnicka E; Jacobsen SEW
Article: BLOOD. 2008;112(4):1048-1055
B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells
Mansson R; Zandi S; Anderson K; Martensson I-L; Jacobsen SEW; Bryder D; Sigvardsson M
Article: MOLECULAR CANCER. 2008;7:67
Exit of pediatric pre-B acute lymphoblastic leukaemia cells from the bone marrow to the peripheral blood is not associated with cell maturation or alterations in gene expression
Hansson F; Toporski J; Mansson R; Johansson B; Noren-Nystrom U; Jacobsen SEW; Wiebe T; Larsson M; Sigvardsson M; Castor A
Article: GENES & DEVELOPMENT. 2008;22(10):1381-1396
NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements
Weischenfeldt J; Damgaard I; Bryder D; Theilgaard-Moench K; Thoren LA; Nielsen FC; Jacobsen SEW; Nerlov C; Porse BT
Article: NATURE CELL BIOLOGY. 2008;10(5):584-592
Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion
Nygren JM; Liuba K; Breitbach M; Stott S; Thoren L; Roell W; Geisen C; Sasse P; Kirik D; Bjorklund A; Nerlov C; Fleischmann BK; Jovinge S; Jacobsen SEW
Article: CANCER CELL. 2008;13(4):299-310
Modeling of C/EBPα mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells
Kirstetter P; Schuster MB; Bereshchenko O; Moore S; Dvinge H; Kurz E; Theilgaard-Monch K; Mansson R; Pedersen TA; Pabst T; Schrock E; Porse BT; Jacobsen SEW; Bertone P; Tenen DG; Nerlov C
Article: BLOOD. 2008;111(7):3424-3434
Down-regulation of Mpl marks the transition to lymphoid-primed multipotent progenitors with gradual loss of granulocyte-monocyte potential
Luc S; Anderson K; Kharazi S; Buza-Vidas N; Boiers C; Jensen CT; Ma Z; Wittmann L; Jacobsen SEW
Article: JOURNAL OF IMMUNOLOGY. 2008;180(4):2045-2053
Kit regulates maintenance of quiescent hematopoietic stem cells
Thoren LA; Liuba K; Bryder D; Nygren JM; Jensen CT; Qian H; Antonchuk J; Jacobsen S-EW
Article: BLOOD. 2008;111(4):2083-2090
Permissive roles of hematopoietin and cytokine tyrosine kinase receptors in early T-cell development
Jensen CT; Boiers C; Kharazi S; Lubking A; Ryden T; Sigvardsson M; Sitnicka E; Jacobsen SEW
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2008;83(1):156-164
Involvement of CCR9 at multiple stages of adult T lymphopoiesis
Svensson M; Marsal J; Uronen-Hansson H; Cheng M; Jenkinson W; Cilio C; Jacobsen SEW; Sitnicka E; Anderson G; Agace WW
Article: BLOOD. 2008;111(1):112-121
Protein kinase B (c-akt) regulates hematopoietic lineage choice decisions during myelopoiesis
Buitenhuis M; Verhagen LP; van Deutekom HWM; Castor A; Verploegen S; Koenderman L; Jacobsen S-EW; Coffer PJ
Article: CELL STEM CELL. 2007;1(6):671-684
Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells
Qian H; Buza-Vidas N; Hyland CD; Jensen CT; Antonchuk J; Mansson R; Thoren LA; Ekblorn M; Alexander WS; Jacobsen SEW
Article: CLINICAL CANCER RESEARCH. 2007;13(23):7107-7112
Negative effect of DNA hypermethylation on the outcome of intensive chemotherapy in older patients with high-risk myelodysplastic syndromes and acute myeloid leukemia following Myelodysplastic syndrome
Grovdal M; Khan R; Aggerholm A; Antunovic P; Astermark J; Bernell P; Engstroem L-V; Kjeldsen L; Linder O; Nilsson L; Olsson A; Wallvik J; Tangen JM; Oberg G; Jacobsen SE; Hokland P; Porwit A; Hellstrom-Lindberg E
Article: BLOOD. 2007;110(8):3005-3014
The molecular signature of MDS stem cells supports a stem-cell origin of 5q -: myelodysplastic syndromes
Nilsson L; Eden P; Olsson E; Mansson R; Astrand-Grundstrom I; Strombeck B; Theilgaard-Monch K; Anderson K; Hast R; Hellstroem-Lindberg E; Samuelsson J; Bergh G; Nerlov C; Johansson B; Sigvardsson M; Borg A; Jacobsen SEW
Article: BLOOD. 2007;110(8):2955-2964
Critical role of FLT3 ligand in IL-7 receptor-independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors
Sitnicka E; Buza-Vidas N; Ahlenius H; Cilio CM; Gekas C; Nygren JM; Mansson R; Cheng M; Jensen CT; Svensson M; Leandersson K; Agace WW; Sigvardsson M; Jacobsen SEW
Article: CANCER CELL. 2007;12(4):367-380
FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia
Lee BH; Tothova Z; Levine RL; Anderson K; Buza-Vidas N; Cullen DE; McDowell EP; Adelsperger J; Frhling S; Huntly BJP; Beran M; Jacobsen SE; Gilliland DG
Article: BLOOD. 2007;110(7):2399-2407
Distinct roles of integrins α6 and α4 in homing of fetal liver hematopoietic stem and progenitor cells
Qian H; Georges-Labouesse E; Nystrom A; Domogatskaya A; Tryggvason K; Jacobsen SEW; Ekblom M
Article: BLOOD. 2007;110(4):1362-1369
Potential risks of bone marrow cell transplantation into infarcted hearts
Breitbach M; Bostani T; Roell W; Xia Y; Dewald O; Nygren JM; Fries JWU; Tiemann K; Bohlen H; Hescheler J; Welz A; Bloch W; Jacobsen SEW; Fleischmann BK
Article: CURRENT OPINION IN HEMATOLOGY. 2007;14(4):315-321
Delineation of the earliest lineage commitment steps of haematopoietic stem cells: new developments, controversies and major challenges
Buza-Vidas N; Luc S; Jacobsen SEW
Article: BLOOD. 2007;110(1):424-432
Crucial role of FLT3 ligand in immune reconstitution after bone marrow transplantation and high-dose chemotherapy
Buza-Vidas N; Cheng M; Duarte S; Nozad H; Jacobsen SEW; Sitnicka E
Article: CANCER RESEARCH. 2007;67(12):5727-5736
CD133 is not present on neurogenic astrocytes in the adult subventricular zone, but on embryonic neural stem cells, ependymal cells, and glioblastoma cells
Pfenninger CV; Roschupkina T; Hertwig F; Kottwitz D; Englund E; Bengzon J; Jacobsen SE; Nuber UA
Article: EMBO JOURNAL. 2007;26(9):2361-2370
Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPα interaction
Fujimoto T; Anderson K; Jacobsen SEW; Nishikawa S-I; Nerlov C
Article: BLOOD. 2007;109(9):3697-3705
Ectopic expression of PAX5 promotes maintenance of biphenotypic myeloid progenitors coexpressing myeloid and B-cell lineage-associated genes
Anderson K; Rusterholz C; Mansson R; Jensen CT; Bacos K; Zandi S; Sasaki Y; Nerlov C; Sigvardsson M; Jacobsen SEW
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2006;203(10):2315-2327
Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium
Kolossov E; Bostani T; Roell W; Breitbach M; Pillekamp F; Nygren JM; Sasse P; Rubenchik O; Fries JWU; Wenzel D; Geisen C; Xia Y; Lu Z; Duan Y; Kettenhofen R; Jovinge S; Bloch W; Bohlen H; Welz A; Hescheler J; Jacobsen SE; Fleischmann BK
Article: NATURE IMMUNOLOGY. 2006;7(10):1048-1056
Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block
Kirstetter P; Anderson K; Porse BT; Jacobsen SEW; Nerlov C
Article: JOURNAL OF NEUROSCIENCE. 2006;26(38):9703-9712
Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis
Iosif RE; Ekdahl CT; Ahlenius H; Pronk CJH; Bonde S; Kokaia Z; Jacobsen S-EW; Lindvall O
Article: GENES & DEVELOPMENT. 2006;20(15):2018-2023
Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK
Buza-Vidas N; Antonchuk J; Qian H; Mansson R; Luc S; Zandi S; Anderson K; Takaki S; Nygren JM; Jensen CT; Jacobsen SEW
Article: JOURNAL OF IMMUNOLOGY. 2006;177(1):201-208
Prolonged cell cycle transit is a defining and developmentally conserved hemopoietic stem cell property
Nygren JM; Bryder D; Jacobsen SEW
Article: STEM CELLS. 2006;24(6):1594-1604
Failure of transdifferentiation of adult hematopoietic stem cells into neurons
Roybon L; Ma Z; Asztely F; Fosum A; Jacobsen SEW; Brundin P; Li J-Y
Article: BLOOD. 2006;107(9):3503-3510
Contribution of α6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with α4 integrins
Qian H; Tryggvason K; Jacobsen SE; Ekblom M
Article: DIABETES. 2006;55(2):290-296
Failure of transplanted bone marrow cells to adopt a pancreatic β-cell fate
Taneera J; Rosengren A; Renstrom E; Nygren JM; Serup P; Rorsman P; Jacobsen SEW
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2005;202(1):85-96
Loss of C/EBPα cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage
Porse BT; Bryder D; Theilgaard-Mönch K; Hasemann MS; Anderson K; Damgaard I; Jacobsen SEW; Nerlov C
Article: BLOOD. 2005;105(11):4272-4281
Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2
Buitenhuis M; van Deutekom HWM; Verhagen LP; Castor A; Jacobsen SEW; Lammers JWJ; Koenderman L; Coffer PJ
Article: BLOOD. 2005;105(7):2717-2723
Identification of Lin^-Sca1⁺kit⁺CD34⁺Flt^3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients
Yang LP; Bryder D; Adolfsson J; Nygren J; Månsson R; Sigvardsson M; Jacobsen SEW
Article: JOURNAL OF GENE MEDICINE. 2005;7(2):137-144
Deficiency of oncoretrovirally transduced hematopoietic stem cells and correction through ex vivo expansion
Bryder D; Björgvinsdóttir H; Sasaki Y; Jacobsen SEW
Article: JOURNAL OF IMMUNOLOGY. 2005;174(2):752-757
IFN-γ negatively modulates self-renewal of repopulating human hemopoietic stem cells
Yang LP; Dybedal I; Bryder D; Nilsson L; Sitnicka E; Sasaki Y; Jacobsen SEW
Article: HAEMATOLOGICA. 2005;90(1):38-44
Biosynthetic profiles of neutrophil serine proteases in a human bone marrow-derived cellular myeloid differentiation model
Garwicz D; Lennartsson A; Jacobsen SEW; Gullberg U; Lindmark A
Article: GENES CHROMOSOMES & CANCER. 2004;41(3):223-231
MDS/AML-associated cytogenetic abnormalities in multiple myeloma and monoclonal gammopathy of undetermined significance: Evidence for frequent de novo occurrence and multipotent stem cell involvement of del(20q)
Nilsson T; Nilsson L; Lenhoff S; Rylander L; Åstrand-Grundström I; Strömbeck B; Höglund M; Turesson I; Westin J; Mitelman F; Jacobsen SEW; Johansson B
Article: BLOOD. 2004;104(4):986-992
Enforced expression of cyclin D2 enhances the proliferative potential of myeloid progenitors, accelerates in vivo myeloid reconstitution, and promotes rescue of mice from lethal myeloablation
Sasaki Y; Jensen CT; Karlsson S; Jacobsen SEW
Article: BMC IMMUNOLOGY. 2004;5:16
P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+ stem and progenitor cells.
Wang L; Jacobsen SEW; Bengtsson A; Erlinge D
Article: NATURE MEDICINE. 2004;10(5):494-501
Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation
Nygren JM; Jovinge S; Breitbach M; Säwén P; Röll W; Hescheler J; Taneera J; Fleischmann BK; Jacobsen SEW
Article: JOURNAL OF IMMUNOLOGY. 2004;172(3):1548-1552
Deceptive multilineage reconstitution analysis of mice transplanted with hemopoietic stem cells, and implications for assessment of stem cell numbers and lineage potentials
Bryder D; Sasaki Y; Borge OJ; Jacobsen SEW
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2003;198(10):1495-1506
Complementary signaling through flt3 and interleukin-7 receptor α is indispensable for fetal and adult B cell genesis
Sitnicka E; Brakebusch C; Martensson IL; Svensson M; Agace WW; Sigvardsson M; Buza-Vidas N; Bryder D; Cilio CM; Ahlenius H; Maraskovsky E; Peschon JJ; Jacobsen SEW
Article: BLOOD. 2003;102(3):881-886
Human CD34⁺ hematopoietic stem cells capable of multilineage engrafting NOD/SCID mice express flt3: distinct flt3 and c-kit expression and response patterns on mouse and candidate human hematopoietic stem cells
Sitnicka E; Buza-Vidas N; Larsson S; Nygren JM; Liuba K; Jacobsen SEW
Article: BLOOD. 2003;102(1):118-126
Human reconstituting hematopoietic stem cells up-regulate Fas expression upon active cell cycling but remain resistant to Fas-induced suppression
Dybedal I; Yang LP; Bryder D; Aastrand-Grundstrom I; Leandersson K; Jacobsen SEW
Article: BLOOD. 2003;101(3):877-885
Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells
Gu YC; Kortesmaa J; Tryggvason K; Persson J; Ekblom P; Jacobsen SE; Ekblom M
Article: IMMUNITY. 2002;17(4):463-472
Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool
Sitnicka E; Bryder D; Theilgaard-Mönch K; Buza-Vidas N; Adolfsson J; Jacobsen SEW
Article: BLOOD. 2002;100(1):259-267
Involvement and functional impairment of the CD34⁺CD38^-Thy-1⁺ hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8
Nilsson L; Åstrand-Grundström I; Anderson K; Arvidsson I; Hokland P; Bryder D; Kjeldsen L; Johansson B; Hellström-Lindberg E; Hast R; Jacobsen SEW
Article: HUMAN GENE THERAPY. 2002;13(9):1061-1073
Efficient oncoretroviral transduction of extended long-term culture-initiating cells and NOD/SCID repopulating cells: Enhanced reconstitution with gene-marked cells through an ex vivo expansion approach
Björgvinsdóttir H; Bryder D; Sitnicka E; Ramsfjell V; De Jong I; Olsson K; Rusterholz C; Karlsson S; Jacobsen SEW
Article: JOURNAL OF IMMUNOLOGY. 2002;168(2):755-762
Transient disruption of autocrine TGF-β signaling leads to enhanced survival and proliferation potential in single primitive human hemopoietic progenitor cells
Fan XL; Valdimarsdottir G; Larsson J; Brun A; Magnusson M; Jacobsen SE; ten Dijke P; Karlsson S
Article: IMMUNITY. 2001;15(4):659-669
Upregulation of flt3 expression within the bone marrow Lin^-Sca1⁺c-kit⁺ stem cell compartment is accompanied by loss of self-renewal capacity
Adolfsson J; Borge OJ; Bryder D; Theilgaard-Mönch K; Åstrand-Grundström I; Sitnicka E; Sasaki Y; Jacobsen SEW
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2001;194(7):941-952
Self-renewal of multipotent long-term repopulating hematopoietic stem cells is negatively regulated by Fas and tumor necrosis factor receptor activation
Bryder D; Ramsfjell V; Dybedal I; Theilgaard-Mönch K; Högerkorp CM; Adolfsson J; Borge OJ; Jacobsen SEW
Article: BLOOD. 2001;98(6):1782-1791
Tumor necrosis factor (TNF)-mediated activation of the p55 TNF receptor negatively regulates maintenance of cycling reconstituting human hematopoietic stem cells
Dybedal I; Bryder D; Fossum A; Rusten LS; Jacobsen SEW
Article: JOURNAL OF VIROLOGY. 2000;74(24):11911-11918
Lentivirus gene transfer in murine hematopoietic progenitor cells is compromised by a delay in proviral integration and results in transduction mosaicism and heterogeneous gene expression in progeny cells
Mikkola H; Woods NB; Sjögren M; Helgadottir H; Hamaguchi I; Jacobsen SE; Trono D; Karlsson S
Article: BLOOD. 2000;96(12):3725-3733
Lentiviral gene transfer into primary and secondary NOD/SCID repopulating cells
Woods NB; Fahlman C; Mikkola H; Hamaguchi S; Olsson K; Zufferey R; Jacobsen SE; Trono D; Karlsson S
Article: BLOOD. 2000;96(6):2012-2021
Isolation and characterization of hematopoietic progenitor/stem cells in 5q-deleted myelodysplastic syndromes: evidence for involvement at the hematopoietic stem cell level
Nilsson L; Åstrand-Grundström I; Arvidsson I; Jacobsson B; Hellström-Lindberg E; Hast R; Jacobsen SEW
Article: BLOOD. 2000;96(5):1748-1755
Interleukin-3 supports expansion of long-term multilineage repopulating activity after multiple stem cell divisions in vitro
Bryder D; Jacobsen SEW
Article: BLOOD. 2000;96(4):1457-1464
Cloning of human early B-cell factor and identification of target genes suggest a conserved role in B-cell development in man and mouse
Gisler R; Jacobsen SEW; Sigvardsson M
Article: HUMAN GENE THERAPY. 2000;11(9):1313-1327
Efficient adenoviral vector transduction of human hematopoietic SCID-repopulating and long-term culture-initiating cells
Fan XL; Brun A; Segrén S; Jacobsen SEW; Karlsson S
Article: BLOOD. 1999;94(12):4093-4102
Distinct requirements for optimal growth and in vitro expansion of human CD34⁺CD38^- bone marrow long-term culture-initiating cells (LTC-IC), extended LTC-IC, and murine in vivo long-term reconstituting stem cells
Ramsfjell V; Bryder D; Björgvinsdóttir H; Kornfält S; Nilsson L; Borge OJ; Jacobsen SEW
Article: BLOOD. 1999;94(11):3781-3790
Lymphoid-restricted development from multipotent candidate murine stem cells:: Distinct and complimentary functions of the c-kit and flt3-ligands
Borge OJ; Adolfsson J; Mårtensson A; Mårtensson IL; Jacobsen SEW
Article: BLOOD. 1999;94(6):1971-1978
Involvement of the retinoblastoma protein in monocytic and neutrophilic lineage commitment of human bone marrow progenitor cells
Bergh G; Ehinger M; Olsson I; Jacobsen SEW; Gullberg U
Article: BLOOD. 1997;90(11):4321-4331
Bidirectional effect of interleukin-10 on early murine B-cell development: Stimulation of flt3-ligand plus interleukin-7-dependent generation of CD19(-) ProB cells from uncommitted bone marrow progenitor cells and growth inhibition of CD19(+) ProB cells
Veiby OP; Borge OJ; Martensson A; Beck EX; Schade AE; Grzegorzewski K; Lyman SD; Martensson IL; Jacobsen SEW
Article: BLOOD. 1997;90(9):3395-3403
Transforming growth factor-beta(1) abrogates Fas-induced growth suppression and apoptosis of murine bone marrow progenitor cells
Dybedal I; Guan FG; Borge OJ; Veiby OP; Ramsfjell V; Nagata S; Jacobsen SEW
Article: BLOOD. 1997;90(6):2282-2292
Ability of early acting cytokines to directly promote survival and suppress apoptosis of human primitive CD34(+)CD38(-) bone marrow cells with multilineage potential at the single-cell level: Key role of thrombopoietin
Borge OJ; Ramsfjell V; Cui L; Jacobsen SEW
Article: JOURNAL OF IMMUNOLOGY. 1997;159(4):1961-1969
Thrombopoietin promotes adhesion of primitive human hemopoietic cells to fibronectin and vascular cell adhesion molecule-1 - Role of activation of very late antigen (VLA)-4 and VLA-5
Cui L; Ramsfjell V; Borge OJ; Veiby OP; Lok S; Jacobsen SEW
Article: BLOOD. 1997;89(12):4415-4424
Interleukin-13 in combination with CD40 ligand potently inhibits apoptosis in human B lymphocytes: Upregulation of Bcl-xL and Mcl-1
Lomo J; Blomhoff HK; Jacobsen SE; Krajewski S; Reed JC; Smeland EB
Article: JOURNAL OF IMMUNOLOGY. 1997;158(11):5169-5177
Thrombopoietin directly and potently stimulates multilineage growth and progenitor cell expansion from primitive (CD34(+)CD38(-)) human bone marrow progenitor cells - Distinct and key interactions with the ligands for c-kit and flt3, and inhibitory EfFects of TGF-beta and TNF-alpha
Ramsfjell V; Borge OJ; Cui L; Jacobsen SEW
Article: BLOOD. 1996;88(12):4481-4492
Thrombopoietin, but not erythropoietin, directly stimulates multilineage growth of primitive murine bone marrow progenitor cells in synergy with early acting cytokines: Distinct interactions with the ligands for c-kit and FLT3
Ramsfjell V; Borge OJ; Veiby OP; Cardier J; Murphy MJ; Lyman SD; Lok S; Jacobsen SEW
Article: BLOOD. 1996;88(8):2859-2870
Thrombopoietin, but not erythropoietin promotes viability and inhibits apoptosis of multipotent murine hematopoietic progenitor cells in vitro
Borge OJ; Ramsfjell V; Veiby OP; Murphy MJ; Lok S; Jacobsen SEW
Article: JOURNAL OF IMMUNOLOGY. 1996;157(7):2953-2960
The flt3 ligand promotes the survival of primitive hemopoietic progenitor cells with myeloid as well as B lymphoid potential - Suppression of apoptosis and counteraction by TNF-alpha and TGF-beta
Veiby OP; Jacobsen FW; Cui L; Lyman SD; Jacobsen SEW
Article: BLOOD. 1996;88(4):1256-1265
Combined signaling through interleukin-7 receptors and flt3 but not c-kit potently and selectively promotes B-cell commitment and differentiation from uncommitted murine bone marrow progenitor cells
Veiby OP; Lyman SD; Jacobsen SEW
Article: JOURNAL OF IMMUNOLOGY. 1996;157(3):1193-1199
TNF-alpha bidirectionally modulates the viability of primitive murine hematopoietic progenitor cells in vitro
Jacobsen FW; Veiby OP; Stokke T; Jacobsen SEW
Article: BLOOD. 1996;87(12):5016-5026
Ability of flt3 ligand to stimulate the in vitro growth of primitive murine hematopoietic progenitors is potently and directly inhibited by transforming growth factor-beta and tumor necrosis factor-alpha
Jacobsen SEW; Veiby OP; Myklebust J; Okkenhaug C; Lyman SD
Article: BLOOD. 1996;87(5):1728-1736
The RAR-RXR as well as the RXR-RXR pathway is involved in signaling growth inhibition of human CD34(+) erythroid progenitor cells
Rusten LS; Dybedal I; Blomhoff HK; Blomhoff R; Smeland EB; Jacobsen SEW
Article: BLOOD. 1996;87(4):1317-1325
The FLT3 ligand is a direct and potent stimulator of the growth of primitive and committed human CD34(+) bone marrow progenitor cells in vitro
Rusten LS; Lyman SD; Veiby OP; Jacobsen SEW
Article: STEM CELLS. 1996;14 Suppl 1:163-172
Megakaryocytopoiesis in vitro: from the stem cells' perspective.
Cardier JE; Foster DC; Lok S; Jacobsen SE; Murphy MJ
Article: BLOOD. 1995;86(8):2957-2966
TRANSFORMING GROWTH-FACTOR-BETA POTENTLY INHIBITS THE VIABILITY-PROMOTING ACTIVITY OF STEM-CELL FACTOR AND OTHER CYTOKINES AND INDUCES APOPTOSIS OF PRIMITIVE MURINE HEMATOPOIETIC PROGENITOR CELLS
JACOBSEN FW; STOKKE T; JACOBSEN SEW
Article: RESEARCH IN IMMUNOLOGY. 1995;146(7-8):506-514
IL12, a direct stimulator and indirect inhibitor of haematopoiesis
Jacobsen SEW
Article: EXPERIMENTAL HEMATOLOGY. 1995;23(9):990-995
DIRECT SYNERGISTIC EFFECTS OF IL-4 AND IL-11 ON PROLIFERATION OF PRIMITIVE HEMATOPOIETIC PROGENITOR CELLS
JACOBSEN FW; KELLER JR; RUSCETTI FW; VEIBY OP; JACOBSEN SEW
Article: BLOOD. 1995;86(3):949-957
TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA), A POTENT INHIBITOR OF ERYTHROPOIESIS - NEUTRALIZING TGF-BETA ANTIBODIES SHOW ERYTHROPOIETIN AS A POTENT STIMULATOR OF MURINE BURST-FORMING UNIT ERYTHROID COLONY FORMATION IN THE ABSENCE OF A BURST-PROMOTING ACTIVITY
DYBEDAL I; JACOBSEN SEW
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 1995;7(1):45-50
RETINOIC ACID POTENTLY STIMULATES THE PRODUCTION OF GRANULOCYTE-COLONY-STIMULATING FACTOR IN THE HUMAN MONOCYTIC THP-1 CELL-LINE
WANG Y; GARG M; GUAN F; DAI W; JACOBSEN SEW; MURPHY MJ
Article: JOURNAL OF IMMUNOLOGY. 1995;155(1):58-65
ALL-TRANS-RETINOIC AND 9-CIS-RETINOIC ACID INHIBIT GROWTH OF NORMAL HUMAN AND MURINE B-CELL PRECURSORS
FAHLMAN C; JACOBSEN SE; SMELAND EB; LOMO J; NAESS CE; FUNDERUD S; BLOMHOFF HK
Article: JOURNAL OF IMMUNOLOGY. 1995;154(10):4950-4955
IL-12 DIRECTLY ENHANCES IN-VITRO MURINE ERYTHROPOIESIS IN COMBINATION WITH IL-4 AND STEM-CELL FACTOR
DYBEDAL I; LARSEN S; JACOBSEN SEW
Article: JOURNAL OF IMMUNOLOGY. 1995;154(8):3732-3741
INHIBITION OF STEM-CELL FACTOR-INDUCED PROLIFERATION OF PRIMITIVE MURINE HEMATOPOIETIC PROGENITOR CELLS SIGNALED THROUGH THE 75-KILODALTON TUMOR-NECROSIS-FACTOR RECEPTOR - REGULATION OF C-KIT AND P53 EXPRESSION
JACOBSEN FW; DUBOIS CM; RUSTEN LS; VEIBY OP; JACOBSEN SEW
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 1995;181(4):1357-1363
THE FLT3 LIGAND POTENTLY AND DIRECTLY STIMULATES THE GROWTH AND EXPANSION OF PRIMITIVE MURINE BONE-MARROW PROGENITOR CELLS IN-VITRO - SYNERGISTIC INTERACTIONS WITH INTERLEUKIN (IL)-11, IL-12, AND OTHER HEMATOPOIETIC GROWTH-FACTORS
JACOBSEN SEW; OKKENHAUG C; MYKLEBUST J; VEIBY OP; LYMAN SD
Article: BLOOD. 1995;85(4):989-996
TUMOR-NECROSIS-FACTOR (TNF)-ALPHA DIRECTLY INHIBITS HUMAN ERYTHROPOIESIS IN-VITRO - ROLE OF P55 AND P75 TNF RECEPTORS
RUSTEN LS; JACOBSEN SEW
Journal article: BLOOD. 1994;84(9):2940-2945
All-Trans Retinoic Acid Directly Inhibits Granulocyte Colony-Stimulating Factor-Induced Proliferation of CD34+ Human Hematopoietic Progenitor Cells
Smeland EB; Rusten L; Jacobsen SEW; Skrede BR; Blomhoff R; Wang MY; Funderud S; Kvalheim G; Blomhoff HK
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1994;91(22):10695-10699
ROLE OF THE 75-KDA TUMOR-NECROSIS-FACTOR RECEPTOR - INHIBITION OF EARLY HEMATOPOIESIS
JACOBSEN FW; ROTHE M; RUSTEN L; GOEDDEL DV; SMELAND EB; VEIBY OP; SLORDAL L; JACOBSEN SEW
Journal article: EXPERIMENTAL HEMATOLOGY. 1994;22(11):1064-1069
DISTINCT AND DIRECT SYNERGISTIC EFFECTS OF IL-1 AND IL-6 ON PROLIFERATION AND DIFFERENTIATION OF PRIMITIVE MURINE HEMATOPOIETIC PROGENITOR CELLS IN-VITRO
JACOBSEN SEW; RUSCETTI FW; OKKENHAUG C; LIEN E; ORTIZ M; VEIBY OP; KELLER JR
Journal article: BLOOD. 1994;84(7):2175-2181
Distinct and overlapping direct effects of macrophage inflammatory protein-1 alpha and transforming growth factor beta on hematopoietic progenitor/stem cell growth
Keller J; Bartelmez S; Sitnicka E; Ruscetti F; Ortiz M; Gooya J; Jacobsen S
Journal article: EXPERIMENTAL HEMATOLOGY. 1994;22(10):985-989
THE GROWTH-RESPONSE OF LIN(-)THY-1(+) HEMATOPOIETIC PROGENITORS TO CYTOKINES IS DETERMINED BY THE BALANCE BETWEEN SYNERGY OF MULTIPLE STIMULATORS AND NEGATIVE COOPERATION OF MULTIPLE INHIBITORS
JACOBSEN SEW; RUSCETTI FW; ORTIZ M; GOOYA JM; KELLER JR
Journal article: BLOOD. 1994;84(5):1450-1456
STEM-CELL FACTOR AND INTERLEUKIN-7 SYNERGIZE TO ENHANCE EARLY MYELOPOIESIS IN-VITRO
FAHLMAN C; BLOMHOFF HK; VEIBY OP; MCNIECE IK; JACOBSEN SEW
Journal article: BLOOD. 1994;84(5):1528-1533
Tumor necrosis factor-alpha (TNF-alpha) potently enhances in vitro macrophage production from primitive murine hematopoietic progenitor cells in combination with stem cell factor and interleukin-7: novel stimulatory role of p55 TNF receptors
Fahlman C; Jacobsen F; Veiby O; McNiece I; Blomhoff H; Jacobsen S
Journal article: BLOOD. 1994;84(5):1473-1481
Functional differences between CD38- and DR- subfractions of CD34+ bone marrow cells
Rusten L; Jacobsen S; Kaalhus O; Veiby O; Funderud S; Smeland E
Journal article: BLOOD. 1994;84(3):775-779
Direct synergistic effects of interleukin-7 on in vitro myelopoiesis of human CD34+ bone marrow progenitors
Jacobsen F; Rusten L; Jacobsen S
Journal article: JOURNAL OF EXPERIMENTAL MEDICINE. 1994;180(1):75-82
INTERLEUKIN-13 - NOVEL ROLE IN DIRECT REGULATION OF PROLIFERATION AND DIFFERENTIATION OF PRIMITIVE HEMATOPOIETIC PROGENITOR CELLS
JACOBSEN SEW; OKKENHAUG C; VEIBY OP; CAPUT D; FERRARA P; MINTY A
Journal article: JOURNAL OF IMMUNOLOGY. 1994;153(1):270-276
IL-7 STIMULATES CSF-INDUCED PROLIFERATION OF MURINE BONE-MARROW MACROPHAGES AND MAC-1(+) MYELOID PROGENITORS IN-VITRO
JACOBSEN FW; VEIBY OP; JACOBSEN SEW
Journal article: JOURNAL OF CLINICAL INVESTIGATION. 1994;94(1):165-172
TUMOR-NECROSIS-FACTOR-ALPHA INHIBITS STEM-CELL FACTOR-INDUCED PROLIFERATION OF HUMAN BONE-MARROW PROGENITOR CELLS IN-VITRO - ROLE OF P55 AND P75 TUMOR-NECROSIS-FACTOR RECEPTORS
RUSTEN LS; SMELAND EB; JACOBSEN FW; LIEN E; LESSLAUER W; LOETSCHER H; DUBOIS CM; JACOBSEN SEW
Journal article: BLOOD. 1994;83(11):3152-3159
BIFUNCTIONAL EFFECTS OF TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) ON THE GROWTH OF MATURE AND PRIMITIVE HUMAN HEMATOPOIETIC PROGENITOR CELLS - INVOLVEMENT OF P55 AND P75 TNF RECEPTORS
RUSTEN LS; JACOBSEN FW; LESSLAUER W; LOETSCHER H; SMELAND EB; JACOBSEN SEW
Journal article: JOURNAL OF EXPERIMENTAL MEDICINE. 1994;179(5):1665-1670
ALL-TRANS-RETINOIC AND 9-CIS-RETINOIC ACID - POTENT DIRECT INHIBITORS OF PRIMITIVE MURINE HEMATOPOIETIC PROGENITORS IN-VITRO
JACOBSEN SEW; FAHLMAN C; BLOMHOFF HK; OKKENHAUG C; RUSTEN LS; SMELAND EB
Journal article: STEM CELLS. 1994;12:111-128
TNF-ALPHA, THE GREAT IMITATOR - ROLE OF P55 AND P75 TNF RECEPTORS IN HEMATOPOIESIS
JACOBSEN SEW; JACOBSEN FW; FAHLMAN C; RUSTEN LS
Journal article: JOURNAL OF IMMUNOLOGY. 1993;151(9):4534-4544
TGF-BETA IS A BIDIRECTIONAL MODULATOR OF CYTOKINE RECEPTOR EXPRESSION ON MURINE BONE-MARROW CELLS - DIFFERENTIAL-EFFECTS OF TGF-BETA-1 AND TGF-BETA-3
JACOBSEN SEW; RUSCETTI FW; ROBERTS AB; KELLER JR
Journal article: JOURNAL OF EXPERIMENTAL MEDICINE. 1993;178(5):1777-1782
NOVEL ROLE OF INTERLEUKIN-7 IN MYELOPOIESIS - STIMULATION OF PRIMITIVE MURINE HEMATOPOIETIC PROGENITOR CELLS
JACOBSEN FW; VEIBY OP; SKJONSBERG C; JACOBSEN SEW
Journal article: JOURNAL OF EXPERIMENTAL MEDICINE. 1993;178(2):413-418
CYTOTOXIC LYMPHOCYTE MATURATION FACTOR (INTERLEUKIN-12) IS A SYNERGISTIC GROWTH-FACTOR FOR HEMATOPOIETIC STEM-CELLS
JACOBSEN SEW; VEIBY OP; SMELAND EB
Journal article: EXPERIMENTAL HEMATOLOGY. 1993;21(6):799-805
INCREASED GRANULOPOIESIS AFTER SEQUENTIAL ADMINISTRATION OF TRANSFORMING GROWTH-FACTOR-BETA-1 AND GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR
HESTDAL K; JACOBSEN SEW; RUSCETTI FW; LONGO DL; BOONE TC; KELLER JR
Journal article: EXPERIMENTAL HEMATOLOGY. 1993;21(2):303-310
HEMATOPOIETIC GROWTH-FACTORS AND GLUCOCORTICOIDS SYNERGIZE TO MIMIC THE EFFECTS OF IL-1 ON GRANULOCYTE DIFFERENTIATION END IL-1 RECEPTOR INDUCTION ON BONE-MARROW CELLS IN-VIVO
DUBOIS CM; NETA R; KELLER JR; JACOBSEN SEW; OPPENHEIM JJ; RUSCETTI F
Journal article: BLOOD. 1992;80(10):2486-2494
INVIVO EFFECT OF INTERLEUKIN-1-ALPHA ON HEMATOPOIESIS - ROLE OF COLONY-STIMULATING FACTOR RECEPTOR MODULATION
HESTDAL K; JACOBSEN SEW; RUSCETTI FW; DUBOIS CM; LONGO DL; CHIZZONITE R; OPPENHEIM JJ; KELLER JR
Journal article: BLOOD. 1992;80(3):678-687
INDUCTION OF COLONY-STIMULATING FACTOR RECEPTOR EXPRESSION ON HEMATOPOIETIC PROGENITOR CELLS - PROPOSED MECHANISM FOR GROWTH-FACTOR SYNERGISM
JACOBSEN SEW; RUSCETTI FW; DUBOIS CM; WINE J; KELLER JR
Journal article: BLOOD. 1992;80(3):600-608
Hematopoietic growth factors upregulate the p65 type II interleukin-1 receptor on bone marrow progenitor cells in vitro
Dubois C; Ruscetti F; Jacobsen S; Oppenheim J; Keller J
Journal article: BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY. 1992;5(3):703-721
TRANSFORMING GROWTH-FACTOR-BETA AND INTERLEUKIN-1 - A PARADIGM FOR OPPOSING REGULATION OF HEMATOPOIESIS
RUSCETTI FW; DUBOIS CM; JACOBSEN SEW; KELLER JR
Journal article: JOURNAL OF EXPERIMENTAL MEDICINE. 1992;175(6):1759-1772
TUMOR-NECROSIS-FACTOR-ALPHA DIRECTLY AND INDIRECTLY REGULATES HEMATOPOIETIC PROGENITOR-CELL PROLIFERATION - ROLE OF COLONY-STIMULATING FACTOR RECEPTOR MODULATION
JACOBSEN SEW; RUSCETTI FW; DUBOIS CM; KELLER JR
Journal article: INTERNATIONAL JOURNAL OF CELL CLONING. 1992;10(1):2-11
TRANSFORMING GROWTH-FACTOR-BETA - A BIDIRECTIONAL REGULATOR OF HEMATOPOIETIC-CELL GROWTH
KELLER JR; JACOBSEN SEW; DUBOIS CM; HESTDAL K; RUSCETTI FW
Journal article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 1991;83(22):1672-1677
ANTINEOPLASTIC DOLASTATINS - POTENT INHIBITORS OF HEMATOPOIETIC PROGENITOR CELLS
JACOBSEN SEW; RUSCETTI FW; LONGO DL; KELLER JR
Journal article: BLOOD. 1991;78(9):2239-2247
BIDIRECTIONAL EFFECTS OF TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA) ON COLONY-STIMULATING FACTOR-INDUCED HUMAN MYELOPOIESIS INVITRO - DIFFERENTIAL-EFFECTS OF DISTINCT TGF-BETA ISOFORMS
JACOBSEN SEW; KELLER JR; RUSCETTI FW; KONDAIAH P; ROBERTS AB; FALK LA
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1991;88(16):7190-7194
STIMULATION OF GRANULOPOIESIS BY TRANSFORMING GROWTH-FACTOR-BETA - SYNERGY WITH GRANULOCYTE MACROPHAGE-COLONY-STIMULATING FACTOR
KELLER JR; JACOBSEN SEW; SILL KT; ELLINGSWORTH LR; RUSCETTI FW
Journal article: JOURNAL OF IMMUNOLOGY. 1991;147(1):22-28
CHARACTERIZATION AND REGULATION OF RB6-8C5 ANTIGEN EXPRESSION ON MURINE BONE-MARROW CELLS
HESTDAL K; RUSCETTI FW; IHLE JN; JACOBSEN SEW; DUBOIS CM; KOPP WC; LONGO DL; KELLER JR
Journal article: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1991;628:31-43
ROLE OF TRANSFORMING GROWTH FACTOR-BETA-1 IN REGULATION OF HEMATOPOIESIS
RUSCETTI FW; JACOBSEN SE; BIRCHENALLROBERTS M; BROXMEYER HE; ENGELMANN GL; DUBOIS C; KELLER JR
Journal article: BLOOD. 1991;77(8):1706-1716
TRANSFORMING GROWTH-FACTOR-BETA TRANS-MODULATES THE EXPRESSION OF COLONY STIMULATING FACTOR RECEPTORS ON MURINE HEMATOPOIETIC PROGENITOR-CELL LINES
JACOBSEN SEW; RUSCETTI FW; DUBOIS CM; LEE J; BOONE TC; KELLER JR
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Alla övriga publikationer

Editorial: NATURE GENETICS. 2025;57(12):2958-2959
Stable, intrinsically programmed lineage restriction of human hematopoietic stem cells
Yoshizato T; Jacobsen SEW
Dataset: KI DATA REPOSITORY. 2025
Codes and data for "Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis"
Yoshizato T; Jacobsen SE
Dataset: KI DATA REPOSITORY. 2025
DNA sequencing data for "Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis"
Yoshizato T; Jacobsen SE
Editorial: CELL RESEARCH. 2025;35(2):93-94
Preservation of a youthful path to evergreen platelets?
Jacobsen SEW
Letter: ANNALS OF INTERNAL MEDICINE. 2025;178(2):300-304
Germline UBA1 Variant With Somatic Amplification in a Woman With Inflammatory Diseases and Myelodysplastic Syndrome
Creignou M; Sirenko M; Moura PL; Mortera-Blanco T; Dimitriou M; Sander B; Domenico D; Ossa JEA; Tesi B; Beck DB; Woll P; Jacobsen S-EW; Papaemmanuil E; Bernard E; Hellstrom-Lindberg E
Editorial: CELL RESEARCH. 2024;34(12):826-827
Rejuvenating immunity through a balancing stem cell act
Jacobsen SEW
Editorial: NATURE IMMUNOLOGY. 2024;25(6):955-956
Non-hierarchically related HSCs replenish platelets by distinct progenitor pathways
Mazzi S; Jacobsen SEW
Dataset: KI DATA REPOSITORY. 2023
DNA sequencing data in MDS-patients treated with allogeneic transplantation
Yoshizato T; Jacobsen SE
Letter: CELL RESEARCH. 2023;33(11):883-886
Platelet and myeloid lineage biases of transplanted single perinatal mouse hematopoietic stem cells
Stralin KB; Carrelha J; Winroth A; Ziegenhain C; Hagemann-Jensen M; Kettyle LM; Hillen A; Hogstrand K; Markljung E; Grasso F; Seki M; Mazzi S; Meng Y; Wu B; Chari E; Lehander M; Sandberg R; Woll PS; Jacobsen SEW
Letter: BLOOD ADVANCES. 2022;6(16):4705-4709
The extent of residual WT HSPCs is associated with the degree of anemia in patients with SF3B1-mutated MDS-RS
Hofman IJF; Mortera-Blanco T; Moura PL; Vestlund J; Larsson SV; Elvarsdottir EM; Walldin G; Tobiasson M; Sander B; Dimitriou M; Jacobsen S-EW; Woll PS; Jadersten M; Hellstrom-Lindberg E
Review: JOURNAL OF INTERNAL MEDICINE. 2022;292(2):262-277
Targeting stem cells in myelodysplastic syndromes and acute myeloid leukemia
Woll PS; Yoshizato T; Hellstrom-Lindberg E; Fioretos T; Ebert BL; Jacobsen SEW
Editorial: ONCOTARGET. 2013;4(6):814-815
Germline Counterparts of Oncogenic Mutations: Who Gives a JAK?
Mead AJ; Constantinescu SN; Jacobsen SEW
Letter: LEUKEMIA. 2013;27(5):1204-1207
Quiescent leukaemic cells account for minimal residual disease in childhood lymphoblastic leukaemia
Lutz C; Woll PS; Hall G; Castor A; Dreau H; Cazzaniga G; Zuna J; Jensen C; Clark SA; Biondi A; Mitchell C; Ferry H; Schuh A; Buckle V; Jacobsen S-EW; Enver T
Letter: NEW ENGLAND JOURNAL OF MEDICINE. 2012;366(10):967-969
Germline JAK2 Mutation in a Family with Hereditary Thrombocytosis
Mead AJ; Rugless MJ; Jacobsen SEW; Schuh A
Editorial: CELL STEM CELL. 2011;8(3):242-244
Clever Leukemic Stem Cells Branch Out
Vyas P; Jacobsen SEW
Editorial: NATURE. 2009;461(7261):183-184
DEVELOPMENTAL BIOLOGY Instructions writ in blood
Enver T; Jacobsen SEW
Review: SEMINARS IN IMMUNOLOGY. 2008;20(4):213-220
Delineating the cellular pathways of hematopoietic lineage commitment
Luc S; Buza-Vidas N; Jacobsen SEW
Letter: NATURE IMMUNOLOGY. 2007;8(9):897
TSLP-mediated fetal B lymphopoiesis?
Jensen CT; Kharazi S; Boeiers C; Liuba K; Jacobsen SEW
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2007;1106:89-94
Biological and molecular evidence for existence of lymphoid-primed multipotent progenitors
Luc S; Buza-Vidas N; Jacobsen SEW
Editorial: NATURE IMMUNOLOGY. 2005;6(3):234-236
Defining 'stemness': Notch and Wnt join forces?
Jacobsen SEW

Forskningsbidrag

Wallenberg Scholar 2024
Knut och Alice Wallenbergs Stiftelse
1 July 2025 - 30 June 2029
Surveillance and targeting of cancer stem cells in myeloid dysplastic syndromes
Cancerfonden
1 January 2024 - 31 December 2026
Stamceller i normal och malign blodbildning
Vetenskapsrådet
1 January 2023 - 30 November 2028
Torsten Söderbergs Academy Professor/ Prize in Medicine 2015, Research grant
Torsten Söderbergs Stiftelse
1 January 2020 - 31 December 2025

Anställningar

Professor Emeritus, Radcliffe Department of Medicine, University of Oxford, 2025-
Professor/Överläkare, Stamcellsbiologi och regenerativ medicin, Cell- och molekylärbiologi, Karolinska Institutet, 2014-
Professor/Överläkare, Stamcellsbiologi och regenerativ medicin, Medicin, Huddinge, Karolinska Institutet, 2014-
Professor, Gäst/Överläkare, Cell- och molekylärbiologi, Karolinska Institutet, 2010-2014

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