Sten Eirik Jacobsen

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About me

Sten Eirik Waelgaard Jacobsen, Professor of Stem Cell Biology and Regenerative Medicine at the Department of Medicine, Huddinge, and the Department of Cell and Molecular Biology, researches how bone marrow stem cells produce blood cells. His research involves exploring the mechanisms and regulation of healthy blood formation and the causes of diseases of the blood, such as leukaemia.

Selected publications

Article: NATURE IMMUNOLOGY. 2024;25(6):1007-1019

Alternative platelet differentiation pathways initiated by nonhierarchically related hematopoietic stem cells.

Carrelha J; Mazzi S; Winroth A; Hagemann-Jensen M; Ziegenhain C; Högstrand K; Seki M; Brennan MS; Lehander M; Wu B; Meng Y; Markljung E; Norfo R; Ishida H; Belander Strålin K; Grasso F; Simoglou Karali C; Aliouat A; Hillen A; Chari E; Siletti K; Thongjuea S; Mead AJ; Linnarsson S; Nerlov C; Sandberg R; Yoshizato T; Woll PS; Jacobsen SEW
Article: NATURE BIOTECHNOLOGY. 2022;40(4):488-498

T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes.

Ali M; Giannakopoulou E; Li Y; Lehander M; Virding Culleton S; Yang W; Knetter C; Odabasi MC; Bollineni RC; Yang X; Foldvari Z; Böschen M-L; Taraldsrud E; Strønen E; Toebes M; Hillen A; Mazzi S; de Ru AH; Janssen GMC; Kolstad A; Tjønnfjord GE; Lie BA; Griffioen M; Lehmann S; Osnes LT; Buechner J; Garcia KC; Schumacher TN; van Veelen PA; Leisegang M; Jacobsen SEW; Woll P; Olweus J
Article: CANCER CELL. 2018;33(2):274-291.e8

Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.

Booth CAG; Barkas N; Neo WH; Boukarabila H; Soilleux EJ; Giotopoulos G; Farnoud N; Giustacchini A; Ashley N; Carrelha J; Jamieson L; Atkinson D; Bouriez-Jones T; Prinjha RK; Milne TA; Teachey DT; Papaemmanuil E; Huntly BJP; Jacobsen SEW; Mead AJ
Article: NATURE. 2018;554(7690):106-111

Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells.

Carrelha J; Meng Y; Kettyle LM; Luis TC; Norfo R; Alcolea V; Boukarabila H; Grasso F; Gambardella A; Grover A; Högstrand K; Lord AM; Sanjuan-Pla A; Woll PS; Nerlov C; Jacobsen SEW
Article: NATURE MEDICINE. 2017;23(6):692-702

Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia.

Giustacchini A; Thongjuea S; Barkas N; Woll PS; Povinelli BJ; Booth CAG; Sopp P; Norfo R; Rodriguez-Meira A; Ashley N; Jamieson L; Vyas P; Anderson K; Segerstolpe Å; Qian H; Olsson-Strömberg U; Mustjoki S; Sandberg R; Jacobsen SEW; Mead AJ
Article: NATURE IMMUNOLOGY. 2016;17(12):1424-1435

Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors.

Luis TC; Luc S; Mizukami T; Boukarabila H; Thongjuea S; Woll PS; Azzoni E; Giustacchini A; Lutteropp M; Bouriez-Jones T; Vaidya H; Mead AJ; Atkinson D; Böiers C; Carrelha J; Macaulay IC; Patient R; Geissmann F; Nerlov C; Sandberg R; de Bruijn MFTR; Blackburn CC; Godin I; Jacobsen SEW
Article: NATURE IMMUNOLOGY. 2016;17(6):666-676

Distinct myeloid progenitor-differentiation pathways identified through single-cell RNA sequencing.

Drissen R; Buza-Vidas N; Woll P; Thongjuea S; Gambardella A; Giustacchini A; Mancini E; Zriwil A; Lutteropp M; Grover A; Mead A; Sitnicka E; Jacobsen SEW; Nerlov C
Corrigendum: CANCER CELL. 2015;27(4):603-605

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo (vol 25, pg 794, 2014)

Woll PS; Kjaellquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstroem-Lindberg E; Linnarsson S; Jacobsen SEW
Article: CELL STEM CELL. 2013;13(5):535-548

Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells.

Böiers C; Carrelha J; Lutteropp M; Luc S; Green JCA; Azzoni E; Woll PS; Mead AJ; Hultquist A; Swiers G; Perdiguero EG; Macaulay IC; Melchiori L; Luis TC; Kharazi S; Bouriez-Jones T; Deng Q; Pontén A; Atkinson D; Jensen CT; Sitnicka E; Geissmann F; Godin I; Sandberg R; de Bruijn MFTR; Jacobsen SEW
Article: NATURE. 2013;502(7470):232-236

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy.

Sanjuan-Pla A; Macaulay IC; Jensen CT; Woll PS; Luis TC; Mead A; Moore S; Carella C; Matsuoka S; Bouriez Jones T; Chowdhury O; Stenson L; Lutteropp M; Green JCA; Facchini R; Boukarabila H; Grover A; Gambardella A; Thongjuea S; Carrelha J; Tarrant P; Atkinson D; Clark S-A; Nerlov C; Jacobsen SEW
Article: NEW ENGLAND JOURNAL OF MEDICINE. 2010;363(11):1025-1037

Persistent malignant stem cells in del(5q) myelodysplasia in remission.

Tehranchi R; Woll PS; Anderson K; Buza-Vidas N; Mizukami T; Mead AJ; Astrand-Grundström I; Strömbeck B; Horvat A; Ferry H; Dhanda RS; Hast R; Rydén T; Vyas P; Göhring G; Schlegelberger B; Johansson B; Hellström-Lindberg E; List A; Nilsson L; Jacobsen SEW
Article: CELL. 2005;121(2):295-306

Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment.

Adolfsson J; Månsson R; Buza-Vidas N; Hultquist A; Liuba K; Jensen CT; Bryder D; Yang L; Borge O-J; Thoren LAM; Anderson K; Sitnicka E; Sasaki Y; Sigvardsson M; Jacobsen SEW

Articles

Journal article: 2024;1(2):100011

Competition of dual SF3B1 mt clones in MDS-RS is associated with distinct RNA mis-splicing in hematopoietic stem cells

Moura PL; Nannya Y; Aliouat A; Hofman IJ; Mortera-Blanco T; Yoshizato T; Saiki R; Nakagawa MM; Creignou M; Björklund A-C; Walldin G; Barbosa I; Jansson M; Grasso F; Elvarsdottir EM; Woll PS; Jacobsen SEW; Ogawa S; Hellström-Lindberg E
Article: JOURNAL OF CLINICAL ONCOLOGY. 2024;42(12):1378-1390

Patient-Specific Measurable Residual Disease Markers Predict Outcome in Patients With Myelodysplastic Syndrome and Related Diseases After Hematopoietic Stem-Cell Transplantation.

Tobiasson M; Pandzic T; Illman J; Nilsson L; Weström S; Ejerblad E; Olesen G; Björklund A; Olsnes Kittang A; Werlenius O; Lorentz F; Rasmussen B; Cammenga J; Weber D; Lindholm C; Wiggh J; Dimitriou M; Moen AE; Yip Lundström L; von Bahr L; Baltzer-Sollander K; Jädersten M; Kytölä S; Walldin G; Ljungman P; Groenbaek K; Mielke S; Jacobsen SEW; Ebeling F; Cavelier L; Smidstrup Friis L; Dybedal I; Hellström-Lindberg E
Article: BLOOD. 2024;143(11):953-966

Identification and surveillance of rare relapse-initiating stem cells during complete remission after transplantation.

Dimitriou M; Mortera-Blanco T; Tobiasson M; Mazzi S; Lehander M; Högstrand K; Karimi M; Walldin G; Jansson M; Vonlanthen S; Ljungman P; Langemeijer S; Yoshizato T; Hellström-Lindberg E; Woll PS; Jacobsen SEW
Article: CANCER RESEARCH. 2024;84(2):211-225

Erythroid Differentiation Enhances RNA Mis-Splicing in SF3B1-Mutant Myelodysplastic Syndromes with Ring Sideroblasts.

Moura PL; Mortera-Blanco T; Hofman IJ; Todisco G; Kretzschmar WW; Björklund A-C; Creignou M; Hagemann-Jensen M; Ziegenhain C; Cabrerizo Granados D; Barbosa I; Walldin G; Jansson M; Ashley N; Mead AJ; Lundin V; Dimitriou M; Yoshizato T; Woll PS; Ogawa S; Sandberg R; Jacobsen SEW; Hellström-Lindberg E
Article: AUTOPHAGY. 2024;20(1):45-57

Autophagy preserves hematopoietic stem cells by restraining MTORC1-mediated cellular anabolism.

Borsa M; Obba S; Richter FC; Zhang H; Riffelmacher T; Carrelha J; Alsaleh G; Jacobsen SEW; Simon AK
Article: BLOOD. 2023;142(19):1622-1632

Loss of endothelial membrane KIT ligand affects systemic KIT ligand levels but not bone marrow hematopoietic stem cells.

Matsuoka S; Facchini R; Luis TC; Carrelha J; Woll PS; Mizukami T; Wu B; Boukarabila H; Buono M; Norfo R; Arai F; Suda T; Mead AJ; Nerlov C; Jacobsen SEW
Article: CLINICAL CANCER RESEARCH. 2023;29(20):4256-4267

Integrated Genomic and Transcriptomic Analysis Improves Disease Classification and Risk Stratification of MDS with Ring Sideroblasts.

Todisco G; Creignou M; Bernard E; Björklund A-C; Moura PL; Tesi B; Mortera-Blanco T; Sander B; Jansson M; Walldin G; Barbosa I; Reinsbach SE; Hofman IJ; Nilsson C; Yoshizato T; Dimitriou M; Chang D; Olafsdottir S; Venckute Larsson S; Tobiasson M; Malcovati L; Woll P; Jacobsen SEW; Papaemmanuil E; Hellström-Lindberg E
Article: NATURE CANCER. 2023;4(10):1474-1490

A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo.

Giannakopoulou E; Lehander M; Virding Culleton S; Yang W; Li Y; Karpanen T; Yoshizato T; Rustad EH; Nielsen MM; Bollineni RC; Tran TT; Delic-Sarac M; Gjerdingen TJ; Douvlataniotis K; Laos M; Ali M; Hillen A; Mazzi S; Chin DWL; Mehta A; Holm JS; Bentzen AK; Bill M; Griffioen M; Gedde-Dahl T; Lehmann S; Jacobsen SEW; Woll PS; Olweus J
Article: NATURE COMMUNICATIONS. 2023;14(1):6062

Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner.

Luis TC; Barkas N; Carrelha J; Giustacchini A; Mazzi S; Norfo R; Wu B; Aliouat A; Guerrero JA; Rodriguez-Meira A; Bouriez-Jones T; Macaulay IC; Jasztal M; Zhu G; Ni H; Robson MJ; Blakely RD; Mead AJ; Nerlov C; Ghevaert C; Jacobsen SEW
Article: NATURE GENETICS. 2023;55(9):1531-1541

Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution.

Rodriguez-Meira A; Norfo R; Wen S; Chédeville AL; Rahman H; O'Sullivan J; Wang G; Louka E; Kretzschmar WW; Paterson A; Brierley C; Martin J-E; Demeule C; Bashton M; Sousos N; Moralli D; Subha Meem L; Carrelha J; Wu B; Hamblin A; Guermouche H; Pasquier F; Marzac C; Girodon F; Vainchenker W; Drummond M; Harrison C; Chapman JR; Plo I; Jacobsen SEW; Psaila B; Thongjuea S; Antony-Debré I; Mead AJ
Journal article: HEMASPHERE. 2023;7(Suppl):e22964a1

P713: EXPLORING CLONAL COMPETITION THROUGH 12‐YEAR FOLLOW‐UP OF AN MDS‐RS PATIENT WITH DUAL SF3B1 MUTATIONS

Moura P; Hofman I; Nannya Y; Aliouat A; Mortera‐Blanco T; Yoshizato T; Saiki R; Nakagawa M; Björklund A; Walldin G; Barbosa I; Jansson M; Grasso F; Creignou M; Elvarsdottir E; Woll P; Jacobsen SE; Ogawa S; Lindberg EH
Article: GENOME BIOLOGY. 2023;24(1):152

Panhematopoietic RNA barcoding enables kinetic measurements of nucleate and anucleate lineages and the activation of myeloid clones following acute platelet depletion.

Wojtowicz EE; Mistry JJ; Uzun V; Hellmich C; Scoones A; Chin DW; Kettyle LM; Grasso F; Lord AM; Wright DJ; Etherington GJ; Woll PS; Belderbos ME; Bowles KM; Nerlov C; Haerty W; Bystrykh LV; Jacobsen SEW; Rushworth SA; Macaulay IC
Article: NATURE CELL BIOLOGY. 2023;25(6):812-822

Epigenetic programming defines haematopoietic stem cell fate restriction.

Meng Y; Carrelha J; Drissen R; Ren X; Zhang B; Gambardella A; Valletta S; Thongjuea S; Jacobsen SE; Nerlov C
Journal article: LEUKEMIA RESEARCH. 2023;128:107135

ACCELERATED RNA SPLICING DYNAMICS DURING ERYTHROID DIFFERENTIATION AMPLIFY MIS-SPLICING IN SF3B1-MUTANT MDS-RS

Moura P; Mortera-Blanco T; Hofman I; Todisco G; Kretzschmar W; Bjorklund A-C; Creignou M; Hagemann-Jensen M; Ziegenhain C; Granados D; Barbosa I; Walldin G; Jansson M; Mead A; Lundin V; Dimitriou M; Yoshizato T; Woll P; Ogawa S; Sandberg R; Jacobsen SE; Hellstrom-Lindberg E
Journal article: EXPERIMENTAL HEMATOLOGY. 2023;124:s64

3028 – LINEAGE BIASED HEMATOPOIETIC STEM CELLS AT TIME OF BIRTH

Strålin KB; Carrelha J; Kettyle L; Hillen A; Högstrand K; Markljung E; Grasso F; Seki M; Mazzi S; Meng Y; Wu B; Chari E; Lehander M; Woll P; Jacobsen SE
Journal article: HEMASPHERE. 2022;6:68-69

S167: PREDICTION OF RELAPSE AFTER ALLOGENEIC STEM CELL TRANSPLANTATION USING INDIVIDUALIZED MEASURABLE RESIDUAL DISEASE MARKERS; THE PROSPECTIVE NORDIC STUDY NMDSG14B

Tobiasson M; Pandzic T; Illman J; Nilsson L; Weström S; Sollander K; Ejerblad E; Kittang AO; Olesen G; Werlenius O; Björklund A; Wiggh J; lindholm C; Lorentz F; Rasmussen B; Cammenga J; Weber D; Grönnås D; Dimitriou M; Kytölä S; Walldin G; Ljungman P; Groenbeck K; Mielke S; Jacobsen SE; Ebeling F; Cavelier L; Friis LS; Dybedal I; Hellström‐Lindberg E
Article: BLOOD. 2022;139(4):629-634

Aged healthy mice acquire clonal hematopoiesis mutations.

Chin DWL; Yoshizato T; Virding Culleton S; Grasso F; Barbachowska M; Ogawa S; Jacobsen SEW; Woll PS
Article: JOURNAL OF IMMUNOLOGY. 2022;208(2):358-370

DNMT1 Deficiency Impacts on Plasmacytoid Dendritic Cells in Homeostasis and Autoimmune Disease.

Czeh M; Stäble S; Krämer S; Tepe L; Talyan S; Carrelha J; Meng Y; Heitplatz B; Schwabenland M; Milsom MD; Plass C; Prinz M; Schlesner M; Andrade-Navarro MA; Nerlov C; Jacobsen SEW; Lipka DB; Rosenbauer F
Journal article: EXPERIMENTAL HEMATOLOGY. 2022;111:s129-s130

3170 – SINGLE-CELL MULTI-OMICS RESOLVES THE EVOLUTION OF TP53-MUTANT LEUKEMIA

Rodriguez-Meira A; Norfo R; Wen W; Chedeville A; Rahman H; O'Sullivan J; Wang G; Louka E; Kretzschmar W; Paterson A; Brierley C; Martin J-E; Demeule C; Bashton M; Sousos N; Hamblin A; Guermouche H; Pasquier F; Marzac C; Girodon F; Drummond M; Harrison C; Plo I; Jacobsen SE; Psaila B; Thongjuea S; Antony-Debré I; Mead A
Journal article: EXPERIMENTAL HEMATOLOGY. 2022;111:s158

3227 – PARALLEL CLONAL AND MOLECULAR PROFILING OF HEMATOPOIETIC STEM CELLS USING RNA BARCODING

wojtowicz E; Mistry J; Uzun V; Scoones A; Chin D; Kettyle L; Lord A; Grasso F; Etherington G; Hellmich C; Woll P; Belderbos M; Bowles K; Bystrykh L; Nerlov C; Haerty W; Jacobsen SE; Rushworth S; Macaulay I
Journal article: EXPERIMENTAL HEMATOLOGY. 2022;111:s50

3011 – EPIGENETIC PROGRAMMING PREDICTS HEMATOPOIETIC STEM CELL FATE RESTRICTION AND PLATELET DIFFERENTIATION KINETICS

Meng Y; Carrelha J; Drissen R; Gambardella A; Thongjuea S; Jacobsen SE; Nerlov C
Article: CELL REPORTS. 2021;37(11):110103

The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition.

Azzoni E; Frontera V; Anselmi G; Rode C; James C; Deltcheva EM; Demian AS; Brown J; Barone C; Patelli A; Harman JR; Nicholls M; Conway SJ; Morrissey E; Jacobsen SEW; Sparrow DB; Harris AL; Enver T; de Bruijn MFTR
Article: NATURE COMMUNICATIONS. 2021;12(1):7019

Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors.

Neo WH; Meng Y; Rodriguez-Meira A; Fadlullah MZH; Booth CAG; Azzoni E; Thongjuea S; de Bruijn MFTR; Jacobsen SEW; Mead AJ; Lacaud G
Article: NATURE CANCER. 2021;2(8):835-852

Chemotherapy induces canalization of cell state in childhood B-cell precursor acute lymphoblastic leukemia.

Turati VA; Guerra-Assunção JA; Potter NE; Gupta R; Ecker S; Daneviciute A; Tarabichi M; Webster AP; Ding C; May G; James C; Brown J; Conde L; Russell LJ; Ancliff P; Inglott S; Cazzaniga G; Biondi A; Hall GW; Lynch M; Hubank M; Macaulay I; Beck S; Van Loo P; Jacobsen SE; Greaves M; Herrero J; Enver T
Article: JOURNAL OF INTERNAL MEDICINE. 2021;289(5):650-661

Stem cell concepts in myelodysplastic syndromes: lessons and challenges.

Woll PS; Jacobsen SEW
Article: DEVELOPMENT. 2021;148(3):dev194563

Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart.

Cahill TJ; Sun X; Ravaud C; Villa Del Campo C; Klaourakis K; Lupu I-E; Lord AM; Browne C; Jacobsen SEW; Greaves DR; Jackson DG; Cowley SA; James W; Choudhury RP; Vieira JM; Riley PR
Article: NATURE COMMUNICATIONS. 2021;12(1):464

Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice.

Papaioannou NE; Salei N; Rambichler S; Ravi K; Popovic J; Küntzel V; Lehmann CHK; Fiancette R; Salvermoser J; Gajdasik DW; Mettler R; Messerer D; Carrelha J; Ohnmacht C; Haller D; Stumm R; Straub T; Jacobsen SEW; Schulz C; Withers DR; Schotta G; Dudziak D; Schraml BU
Article: JOURNAL OF TRANSLATIONAL AUTOIMMUNITY. 2020;3:100066

cDC1 are required for the initiation of collagen-induced arthritis.

Ramos MI; Garcia S; Helder B; Aarrass S; Reedquist KA; Jacobsen SE; Tak PP; Lebre MC
Journal article: EXPERIMENTAL HEMATOLOGY. 2019;76:s77

PERIVASCULAR NICHE CELLS SENSE THROMBOCYTOPENIA AND ACTIVATE PLATELET-BIASED STEM CELLS IN AN IL-1 DEPENDENT MANNER

Luis T; Abdulla H; Davies T; Jackson J; Vo A; Alserihi R; Viney E; Wong T; Shi W; Alexander W; Dickins R; Shields B
Article: MOLECULAR CELL. 2019;73(6):1292-1305.e8

Unravelling Intratumoral Heterogeneity through High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA Sequencing.

Rodriguez-Meira A; Buck G; Clark S-A; Povinelli BJ; Alcolea V; Louka E; McGowan S; Hamblin A; Sousos N; Barkas N; Giustacchini A; Psaila B; Jacobsen SEW; Thongjuea S; Mead AJ
Article: NATURE CELL BIOLOGY. 2019;21(1):2-8

Haematopoiesis in the era of advanced single-cell technologies.

Jacobsen SEW; Nerlov C
Article: JOURNAL OF IMMUNOLOGY. 2018;201(11):3307-3319

Loss of Canonical Notch Signaling Affects Multiple Steps in NK Cell Development in Mice.

Chaves P; Zriwil A; Wittmann L; Boukarabila H; Peitzsch C; Jacobsen SEW; Sitnicka E
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2018;183(4):588-600

Direct role of FLT3 in regulation of early lymphoid progenitors.

Zriwil A; Böiers C; Kristiansen TA; Wittmann L; Yuan J; Nerlov C; Sitnicka E; Jacobsen SEW
Article: EMBO REPORTS. 2018;19(10):e45477

Kit ligand has a critical role in mouse yolk sac and aorta-gonad-mesonephros hematopoiesis.

Azzoni E; Frontera V; McGrath KE; Harman J; Carrelha J; Nerlov C; Palis J; Jacobsen SEW; de Bruijn MF
Article: ONCOSCIENCE. 2018;5(11-12):271-272

Origins of ETP leukemia.

Booth CAG; Jacobsen SEW; Mead AJ
Journal article: EXPERIMENTAL HEMATOLOGY. 2018;64:s97

3149 Single Cell Analysis Resolves Genetic and Transcriptional Heterogeneity in Myeloproliferative Neoplasms

Rodriguez-Meira A; Buck G; Clark S; Louka E; Povinelli B; Barkas N; McGowan S; Sousos N; Giustacchini A; Hamblin A; Jacobsen S; Thongjuea S; Mead A
Article: BLOOD. 2018;131(20):2223-2234

Cell-extrinsic hematopoietic impact of Ezh2 inactivation in fetal liver endothelial cells.

Neo WH; Booth CAG; Azzoni E; Chi L; Delgado-Olguín P; de Bruijn MFTR; Jacobsen SEW; Mead AJ
Article: BLOOD. 2018;131(15):1712-1719

Canonical Notch signaling is dispensable for adult steady-state and stress myelo-erythropoiesis.

Duarte S; Woll PS; Buza-Vidas N; Chin DWL; Boukarabila H; Luís TC; Stenson L; Bouriez-Jones T; Ferry H; Mead AJ; Atkinson D; Jin S; Clark S-A; Wu B; Repapi E; Gray N; Taylor S; Mutvei AP; Tsoi YL; Nerlov C; Lendahl U; Jacobsen SEW
Article: DEVELOPMENTAL CELL. 2018;44(3):362-377.e7

A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1.

Böiers C; Richardson SE; Laycock E; Zriwil A; Turati VA; Brown J; Wray JP; Wang D; James C; Herrero J; Sitnicka E; Karlsson S; Smith AJH; Jacobsen SEW; Enver T
Article: CELL STEM CELL. 2018;22(2):262-276.e7

In Vivo Labeling by CD73 Marks Multipotent Stromal Cells and Highlights Endothelial Heterogeneity in the Bone Marrow Niche.

Breitbach M; Kimura K; Luis TC; Fuegemann CJ; Woll PS; Hesse M; Facchini R; Rieck S; Jobin K; Reinhardt J; Ohneda O; Wenzel D; Geisen C; Kurts C; Kastenmüller W; Hölzel M; Jacobsen SEW; Fleischmann BK
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2017;214(10):3085-3104

Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program.

Loughran SJ; Comoglio F; Hamey FK; Giustacchini A; Errami Y; Earp E; Göttgens B; Jacobsen SEW; Mead AJ; Hendrich B; Green AR
Article: IMMUNITY. 2017;47(3):466-480.e5

Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation.

Riffelmacher T; Clarke A; Richter FC; Stranks A; Pandey S; Danielli S; Hublitz P; Yu Z; Johnson E; Schwerd T; McCullagh J; Uhlig H; Jacobsen SEW; Simon AK
Article: BLOOD. 2017;130(7):881-890

SF3B1-initiating mutations in MDS-RSs target lymphomyeloid hematopoietic stem cells.

Mortera-Blanco T; Dimitriou M; Woll PS; Karimi M; Elvarsdottir E; Conte S; Tobiasson M; Jansson M; Douagi I; Moarii M; Saft L; Papaemmanuil E; Jacobsen SEW; Hellström-Lindberg E
Article: CELL REPORTS. 2017;20(3):572-585

Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes.

Unnikrishnan A; Papaemmanuil E; Beck D; Deshpande NP; Verma A; Kumari A; Woll PS; Richards LA; Knezevic K; Chandrakanthan V; Thoms JAI; Tursky ML; Huang Y; Ali Z; Olivier J; Galbraith S; Kulasekararaj AG; Tobiasson M; Karimi M; Pellagatti A; Wilson SR; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen SEW; Mufti GJ; Hellstrom-Lindberg E; Wilkins MR; MacKenzie KL; Wong JWH; Campbell PJ; Pimanda JE
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2017;214(7):2005-2021

Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation.

Mead AJ; Neo WH; Barkas N; Matsuoka S; Giustacchini A; Facchini R; Thongjuea S; Jamieson L; Booth CAG; Fordham N; Di Genua C; Atkinson D; Chowdhury O; Repapi E; Gray N; Kharazi S; Clark S-A; Bouriez T; Woll P; Suda T; Nerlov C; Jacobsen SEW
Article: HAEMATOLOGICA. 2017;102(3):498-508

Progression in patients with low- and intermediate-1-risk del(5q) myelodysplastic syndromes is predicted by a limited subset of mutations.

Scharenberg C; Giai V; Pellagatti A; Saft L; Dimitriou M; Jansson M; Jädersten M; Grandien A; Douagi I; Neuberg DS; LeBlanc K; Boultwood J; Karimi M; Jacobsen SEW; Woll PS; Hellström-Lindberg E
Journal article: BLOOD. 2016;128(22):4329

Progression in Patients with with Low- and Intermediate-1 Risk Del(5q) MDS Is Predicted By a Limited Subset of Mutations

Scharenberg C; Woll PS; Giai V; Pellagatti A; Saft L; Dimitriou M; Jädersten M; Jansson M; Douagi I; Neuberg DS; Karimi M; Le Blanc K; Boultwood J; Jacobsen SE; Hellstrom-Lindberg E
Article: ONCOTARGET. 2016;7(45):72685-72698

Perturbed hematopoietic stem and progenitor cell hierarchy in myelodysplastic syndromes patients with monosomy 7 as the sole cytogenetic abnormality.

Dimitriou M; Woll PS; Mortera-Blanco T; Karimi M; Wedge DC; Doolittle H; Douagi I; Papaemmanuil E; Jacobsen SEW; Hellström-Lindberg E
Journal article: EXPERIMENTAL HEMATOLOGY. 2016;44(9):s46

DISTINCT MYELOID PROGENITOR DIFFERENTIATION PATHWAYS IDENTIFIED THROUGH SINGLE CELL RNA SEQUENCING

Nerlov C; Drissen R; Buza-Vidas N; Woll P; Thongjuea S; Gambardella A; Giustacchini A; Jacobsen SE
Article: CELL REPORTS. 2016;16(4):1039-1054

Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development.

Barrett NA; Malouf C; Kapeni C; Bacon WA; Giotopoulos G; Jacobsen SEW; Huntly BJ; Ottersbach K
Article: BLOOD. 2016;128(2):217-226

Macrophage colony-stimulating factor receptor marks and regulates a fetal myeloid-primed B-cell progenitor in mice.

Zriwil A; Böiers C; Wittmann L; Green JCA; Woll PS; Jacobsen SEW; Sitnicka E
Journal article: EUROPEAN JOURNAL OF CANCER. 2016;61:s104

481 Single cell analysis of intratumour heterogeneity in childhood acute lymphoblastic leukaemia

Turati V; Mike H; Herrero J; John A; Richardson S; Gaal B; Mark L; Jacobsen SE; Enver T
Article: CIRCULATION RESEARCH. 2016;118(10):1498-1511

Primitive Embryonic Macrophages are Required for Coronary Development and Maturation.

Leid J; Carrelha J; Boukarabila H; Epelman S; Jacobsen SEW; Lavine KJ
Article: NATURE COMMUNICATIONS. 2016;7:11075

Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells.

Grover A; Sanjuan-Pla A; Thongjuea S; Carrelha J; Giustacchini A; Gambardella A; Macaulay I; Mancini E; Luis TC; Mead A; Jacobsen SEW; Nerlov C
Article: NATURE CELL BIOLOGY. 2016;18(2):157-167

A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors.

Buono M; Facchini R; Matsuoka S; Thongjuea S; Waithe D; Luis TC; Giustacchini A; Besmer P; Mead AJ; Jacobsen SEW; Nerlov C
Article: CELL DEATH DISCOVERY. 2015;1:15008

Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia.

Watson AS; Riffelmacher T; Stranks A; Williams O; De Boer J; Cain K; MacFarlane M; McGouran J; Kessler B; Khandwala S; Chowdhury O; Puleston D; Phadwal K; Mortensen M; Ferguson D; Soilleux E; Woll P; Jacobsen SEW; Simon AK
Article: NATURE COMMUNICATIONS. 2015;6:6930

PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium.

Noseda M; Harada M; McSweeney S; Leja T; Belian E; Stuckey DJ; Abreu Paiva MS; Habib J; Macaulay I; de Smith AJ; al-Beidh F; Sampson R; Lumbers RT; Rao P; Harding SE; Blakemore AIF; Jacobsen SE; Barahona M; Schneider MD
Article: ANNALS OF THE RHEUMATIC DISEASES. 2015;74(1):211-219

Absence of Fms-like tyrosine kinase 3 ligand (Flt3L) signalling protects against collagen-induced arthritis.

Ramos MIP; Karpus ON; Broekstra P; Aarrass S; Jacobsen SE; Tak PP; Lebre MC
Article: LEUKEMIA. 2015;29(1):38-50

Clonal variegation and dynamic competition of leukemia-initiating cells in infant acute lymphoblastic leukemia with MLL rearrangement.

Bardini M; Woll PS; Corral L; Luc S; Wittmann L; Ma Z; Lo Nigro L; Basso G; Biondi A; Cazzaniga G; Jacobsen SEW
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2014;93(5):439-445

A pilot phase I dose finding safety study of the thrombopoietin-receptor agonist, eltrombopag, in patients with myelodysplastic syndrome treated with azacitidine.

Svensson T; Chowdhury O; Garelius H; Lorenz F; Saft L; Jacobsen S-E; Hellström-Lindberg E; Cherif H
Article: CANCER CELL. 2014;25(6):794-808

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.

Woll PS; Kjällquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Göhring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellström-Lindberg E; Linnarsson S; Jacobsen SEW
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2014;211(2):181-188

Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate.

Grover A; Mancini E; Moore S; Mead AJ; Atkinson D; Rasmussen KD; O'Carroll D; Jacobsen SEW; Nerlov C
Article: CELL REPORTS. 2013;3(6):1766-1776

FLT3-ITDs instruct a myeloid differentiation and transformation bias in lymphomyeloid multipotent progenitors.

Mead AJ; Kharazi S; Atkinson D; Macaulay I; Pecquet C; Loughran S; Lutteropp M; Woll P; Chowdhury O; Luc S; Buza-Vidas N; Ferry H; Clark S-A; Goardon N; Vyas P; Constantinescu SN; Sitnicka E; Nerlov C; Jacobsen SEW
Article: IMMUNITY. 2013;38(5):930-942

Transcriptional repression of Gata3 is essential for early B cell commitment.

Banerjee A; Northrup D; Boukarabila H; Jacobsen SEW; Allman D
Article: BLOOD. 2013;121(20):4156-4165

Impact of isolated germline JAK2V617I mutation on human hematopoiesis.

Mead AJ; Chowdhury O; Pecquet C; Dusa A; Woll P; Atkinson D; Burns A; Score J; Rugless M; Clifford R; Moule S; Bienz N; Vyas P; Cross N; Gale RE; Henderson S; Constantinescu SN; Schuh A; Jacobsen SEW
Article: NATURE CELL BIOLOGY. 2013;15(4):363-372

Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis.

Moignard V; Macaulay IC; Swiers G; Buettner F; Schütte J; Calero-Nieto FJ; Kinston S; Joshi A; Hannah R; Theis FJ; Jacobsen SE; de Bruijn MF; Göttgens B
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2013;160(6):842-850

Silencing of ASXL1 impairs the granulomonocytic lineage potential of human CD34⁺ progenitor cells.

Davies C; Yip BH; Fernandez-Mercado M; Woll PS; Agirre X; Prosper F; Jacobsen SE; Wainscoat JS; Pellagatti A; Boultwood J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(43):17579-17584

Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21.

Roy A; Cowan G; Mead AJ; Filippi S; Bohn G; Chaidos A; Tunstall O; Chan JKY; Choolani M; Bennett P; Kumar S; Atkinson D; Wyatt-Ashmead J; Hu M; Stumpf MPH; Goudevenou K; O'Connor D; Chou ST; Weiss MJ; Karadimitris A; Jacobsen SE; Vyas P; Roberts I
Article: BLOOD. 2012;120(12):2412-2416

Dicer is selectively important for the earliest stages of erythroid development.

Buza-Vidas N; Cismasiu VB; Moore S; Mead AJ; Woll PS; Lutteropp M; Melchiori L; Luc S; Bouriez-Jones T; Atkinson D; O'Carroll D; Jacobsen SEW; Nerlov C
Article: BLOOD. 2012;120(1):63-75

Emergence of NK-cell progenitors and functionally competent NK-cell lineage subsets in the early mouse embryo.

Tang Y; Peitzsch C; Charoudeh HN; Cheng M; Chaves P; Jacobsen SEW; Sitnicka E
Article: LEUKEMIA. 2012;26(7):1527-1536

Molecular and cellular effects of oncogene cooperation in a genetically accurate AML mouse model.

Reckzeh K; Bereshchenko O; Mead A; Rehn M; Kharazi S; Jacobsen S-E; Nerlov C; Cammenga J
Article: JOURNAL OF NEUROSCIENCE. 2012;32(15):5151-5164

Adaptor protein LNK is a negative regulator of brain neural stem cell proliferation after stroke.

Ahlenius H; Devaraju K; Monni E; Oki K; Wattananit S; Darsalia V; Iosif RE; Torper O; Wood JC; Braun S; Jagemann L; Nuber UA; Englund E; Jacobsen S-EW; Lindvall O; Kokaia Z
Article: SCIENCE. 2012;336(6077):86-90

A lineage of myeloid cells independent of Myb and hematopoietic stem cells.

Schulz C; Gomez Perdiguero E; Chorro L; Szabo-Rogers H; Cagnard N; Kierdorf K; Prinz M; Wu B; Jacobsen SEW; Pollard JW; Frampton J; Liu KJ; Geissmann F
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2012;209(3):537-549

Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow.

Mansour A; Abou-Ezzi G; Sitnicka E; Jacobsen SEW; Wakkach A; Blin-Wakkach C
Article: NATURE IMMUNOLOGY. 2012;13(4):412-419

The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential.

Luc S; Luis TC; Boukarabila H; Macaulay IC; Buza-Vidas N; Bouriez-Jones T; Lutteropp M; Woll PS; Loughran SJ; Mead AJ; Hultquist A; Brown J; Mizukami T; Matsuoka S; Ferry H; Anderson K; Duarte S; Atkinson D; Soneji S; Domanski A; Farley A; Sanjuan-Pla A; Carella C; Patient R; de Bruijn M; Enver T; Nerlov C; Blackburn C; Godin I; Jacobsen SEW
Article: EMBO JOURNAL. 2012;31(2):351-365

FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors.

Mancini E; Sanjuan-Pla A; Luciani L; Moore S; Grover A; Zay A; Rasmussen KD; Luc S; Bilbao D; O'Carroll D; Jacobsen SE; Nerlov C
Article: PLOS GENETICS. 2011;7(12):e1002404

Acute multiple organ failure in adult mice deleted for the developmental regulator Wt1.

Chau Y-Y; Brownstein D; Mjoseng H; Lee W-C; Buza-Vidas N; Nerlov C; Jacobsen SE; Perry P; Berry R; Thornburn A; Sexton D; Morton N; Hohenstein P; Freyer E; Samuel K; van't Hof R; Hastie N
Article: BLOOD. 2011;118(13):3613-3621

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.

Kharazi S; Mead AJ; Mansour A; Hultquist A; Böiers C; Luc S; Buza-Vidas N; Ma Z; Ferry H; Atkinson D; Reckzeh K; Masson K; Cammenga J; Rönnstrand L; Arai F; Suda T; Nerlov C; Sitnicka E; Jacobsen SEW
Article: BLOOD. 2011;118(6):1544-1548

FLT3 expression initiates in fully multipotent mouse hematopoietic progenitor cells.

Buza-Vidas N; Woll P; Hultquist A; Duarte S; Lutteropp M; Bouriez-Jones T; Ferry H; Luc S; Jacobsen SEW
Article: BLOOD. 2011;118(5):1291-1293

GATA3 is redundant for maintenance and self-renewal of hematopoietic stem cells.

Buza-Vidas N; Duarte S; Luc S; Bouriez-Jones T; Woll PS; Jacobsen SEW
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2011;208(8):1563-1570

Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors.

Pronk CJH; Veiby OP; Bryder D; Jacobsen SEW
Article: EPIGENETICS & CHROMATIN. 2011;4(1):9

Generation of bivalent chromatin domains during cell fate decisions.

De Gobbi M; Garrick D; Lynch M; Vernimmen D; Hughes JR; Goardon N; Luc S; Lower KM; Sloane-Stanley JA; Pina C; Soneji S; Renella R; Enver T; Taylor S; Jacobsen SEW; Vyas P; Gibbons RJ; Higgs DR
Article: BLOOD. 2011;117(13):3521-3528

Hoxb4-YFP reporter mouse model: a novel tool for tracking HSC development and studying the role of Hoxb4 in hematopoiesis.

Hills D; Gribi R; Ure J; Buza-Vidas N; Luc S; Jacobsen SEW; Medvinsky A
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2011;208(3):455-467

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance.

Mortensen M; Soilleux EJ; Djordjevic G; Tripp R; Lutteropp M; Sadighi-Akha E; Stranks AJ; Glanville J; Knight S; Jacobsen S-EW; Kranc KR; Simon AK
Article: CANCER CELL. 2011;19(1):138-152

Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia.

Goardon N; Marchi E; Atzberger A; Quek L; Schuh A; Soneji S; Woll P; Mead A; Alford KA; Rout R; Chaudhury S; Gilkes A; Knapper S; Beldjord K; Begum S; Rose S; Geddes N; Griffiths M; Standen G; Sternberg A; Cavenagh J; Hunter H; Bowen D; Killick S; Robinson L; Price A; Macintyre E; Virgo P; Burnett A; Craddock C; Enver T; Jacobsen SEW; Porcher C; Vyas P
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2010;150(3):293-302

Maintenance treatment with azacytidine for patients with high-risk myelodysplastic syndromes (MDS) or acute myeloid leukaemia following MDS in complete remission after induction chemotherapy.

Grövdal M; Karimi M; Khan R; Aggerholm A; Antunovic P; Astermark J; Bernell P; Engström L-M; Kjeldsen L; Linder O; Nilsson L; Olsson A; Holm MS; Tangen JM; Wallvik J; Oberg G; Hokland P; Jacobsen SE; Porwit A; Hellström-Lindberg E
Article: BLOOD. 2010;116(2):183-192

Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells.

Nozad Charoudeh H; Tang Y; Cheng M; Cilio CM; Jacobsen SEW; Sitnicka E
Article: BLOOD. 2010;115(24):5061-5068

Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development.

Böiers C; Buza-Vidas N; Jensen CT; Pronk CJH; Kharazi S; Wittmann L; Sitnicka E; Hultquist A; Jacobsen SEW
Article: CELL STEM CELL. 2009;5(6):659-665

Cited2 is an essential regulator of adult hematopoietic stem cells.

Kranc KR; Schepers H; Rodrigues NP; Bamforth S; Villadsen E; Ferry H; Bouriez-Jones T; Sigvardsson M; Bhattacharya S; Jacobsen SE; Enver T
Article: CANCER CELL. 2009;16(5):390-400

Hematopoietic stem cell expansion precedes the generation of committed myeloid leukemia-initiating cells in C/EBPalpha mutant AML.

Bereshchenko O; Mancini E; Moore S; Bilbao D; Månsson R; Luc S; Grover A; Jacobsen SEW; Bryder D; Nerlov C
Article: NATURE GENETICS. 2009;41(11):1207-1215

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.

Bröske A-M; Vockentanz L; Kharazi S; Huska MR; Mancini E; Scheller M; Kuhl C; Enns A; Prinz M; Jaenisch R; Nerlov C; Leutz A; Andrade-Navarro MA; Jacobsen SEW; Rosenbauer F
Article: GLIA. 2009;57(8):835-849

Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke.

Thored P; Heldmann U; Gomes-Leal W; Gisler R; Darsalia V; Taneera J; Nygren JM; Jacobsen S-EW; Ekdahl CT; Kokaia Z; Lindvall O
Article: BLOOD. 2009;113(19):4790-4798

Polyclonal T-cell reconstitution of X-SCID recipients after in utero transplantation of lymphoid-primed multipotent progenitors.

Liuba K; Pronk CJH; Stott SRW; Jacobsen S-EW
Article: BLOOD. 2009;113(15):3453-3460

FLT3 receptor and ligand are dispensable for maintenance and posttransplantation expansion of mouse hematopoietic stem cells.

Buza-Vidas N; Cheng M; Duarte S; Charoudeh HN; Jacobsen SEW; Sitnicka E
Article: BLOOD. 2009;113(12):2661-2672

High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle.

Tipping AJ; Pina C; Castor A; Hong D; Rodrigues NP; Lazzari L; May GE; Jacobsen SEW; Enver T
Article: JOURNAL OF IMMUNOLOGY. 2009;182(3):1460-1468

Distinct and overlapping patterns of cytokine regulation of thymic and bone marrow-derived NK cell development.

Cheng M; Charoudeh HN; Brodin P; Tang Y; Lakshmikanth T; Höglund P; Jacobsen SEW; Sitnicka E
Article: CYTOTHERAPY. 2009;11(2):114-128

Characterization of bone marrow-derived mesenchymal stromal cells (MSC) based on gene expression profiling of functionally defined MSC subsets.

Tormin A; Brune JC; Olsson E; Valcich J; Neuman U; Olofsson T; Jacobsen S-E; Scheding S
Article: BLOOD. 2008;112(6):2297-2304

FLT3 ligand and not TSLP is the key regulator of IL-7-independent B-1 and B-2 B lymphopoiesis.

Jensen CT; Kharazi S; Böiers C; Cheng M; Lübking A; Sitnicka E; Jacobsen SEW
Article: BLOOD. 2008;112(4):1048-1055

B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells.

Mansson R; Zandi S; Anderson K; Martensson I-L; Jacobsen SEW; Bryder D; Sigvardsson M
Article: MOLECULAR CANCER. 2008;7:67

Exit of pediatric pre-B acute lymphoblastic leukaemia cells from the bone marrow to the peripheral blood is not associated with cell maturation or alterations in gene expression.

Hansson F; Toporski J; Månsson R; Johansson B; Norén-Nyström U; Jacobsen SEW; Wiebe T; Larsson M; Sigvardsson M; Castor A
Article: GENES & DEVELOPMENT. 2008;22(10):1381-1396

NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements.

Weischenfeldt J; Damgaard I; Bryder D; Theilgaard-Mönch K; Thoren LA; Nielsen FC; Jacobsen SEW; Nerlov C; Porse BT
Article: NATURE CELL BIOLOGY. 2008;10(5):584-592

Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.

Nygren JM; Liuba K; Breitbach M; Stott S; Thorén L; Roell W; Geisen C; Sasse P; Kirik D; Björklund A; Nerlov C; Fleischmann BK; Jovinge S; Jacobsen SEW
Article: BLOOD. 2008;111(7):3424-3434

Down-regulation of Mpl marks the transition to lymphoid-primed multipotent progenitors with gradual loss of granulocyte-monocyte potential.

Luc S; Anderson K; Kharazi S; Buza-Vidas N; Böiers C; Jensen CT; Ma Z; Wittmann L; Jacobsen SEW
Article: CANCER CELL. 2008;13(4):299-310

Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells.

Kirstetter P; Schuster MB; Bereshchenko O; Moore S; Dvinge H; Kurz E; Theilgaard-Mönch K; Månsson R; Pedersen TA; Pabst T; Schrock E; Porse BT; Jacobsen SEW; Bertone P; Tenen DG; Nerlov C
Article: JOURNAL OF IMMUNOLOGY. 2008;180(4):2045-2053

Kit regulates maintenance of quiescent hematopoietic stem cells.

Thorén LA; Liuba K; Bryder D; Nygren JM; Jensen CT; Qian H; Antonchuk J; Jacobsen S-EW
Article: BLOOD. 2008;111(4):2083-2090

Permissive roles of hematopoietin and cytokine tyrosine kinase receptors in early T-cell development.

Jensen CT; Böiers C; Kharazi S; Lübking A; Rydén T; Sigvardsson M; Sitnicka E; Jacobsen SEW
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2008;83(1):156-164

Involvement of CCR9 at multiple stages of adult T lymphopoiesis.

Svensson M; Marsal J; Uronen-Hansson H; Cheng M; Jenkinson W; Cilio C; Jacobsen SEW; Sitnicka E; Anderson G; Agace WW
Article: BLOOD. 2008;111(1):112-121

Protein kinase B (c-akt) regulates hematopoietic lineage choice decisions during myelopoiesis.

Buitenhuis M; Verhagen LP; van Deutekom HWM; Castor A; Verploegen S; Koenderman L; Jacobsen S-EW; Coffer PJ
Article: CELL STEM CELL. 2007;1(6):671-684

Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells.

Qian H; Buza-Vidas N; Hyland CD; Jensen CT; Antonchuk J; Månsson R; Thoren LA; Ekblom M; Alexander WS; Jacobsen SEW
Article: CLINICAL CANCER RESEARCH. 2007;13(23):7107-7112

Negative effect of DNA hypermethylation on the outcome of intensive chemotherapy in older patients with high-risk myelodysplastic syndromes and acute myeloid leukemia following myelodysplastic syndrome.

Grövdal M; Khan R; Aggerholm A; Antunovic P; Astermark J; Bernell P; Engström L-M; Kjeldsen L; Linder O; Nilsson L; Olsson A; Wallvik J; Tangen JM; Oberg G; Jacobsen SE; Hokland P; Porwit A; Hellström-Lindberg E
Article: BLOOD. 2007;110(8):3005-3014

The molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes.

Nilsson L; Edén P; Olsson E; Månsson R; Astrand-Grundström I; Strömbeck B; Theilgaard-Mönch K; Anderson K; Hast R; Hellström-Lindberg E; Samuelsson J; Bergh G; Nerlov C; Johansson B; Sigvardsson M; Borg A; Jacobsen SEW
Article: BLOOD. 2007;110(8):2955-2964

Critical role of FLT3 ligand in IL-7 receptor independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors.

Sitnicka E; Buza-Vidas N; Ahlenius H; Cilio CM; Gekas C; Nygren JM; Månsson R; Cheng M; Jensen CT; Svensson M; Leandersson K; Agace WW; Sigvardsson M; Jacobsen SEW
Article: CANCER CELL. 2007;12(4):367-380

FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia.

Lee BH; Tothova Z; Levine RL; Anderson K; Buza-Vidas N; Cullen DE; McDowell EP; Adelsperger J; Fröhling S; Huntly BJP; Beran M; Jacobsen SE; Gilliland DG
Article: BLOOD. 2007;110(7):2399-2407

Distinct roles of integrins alpha6 and alpha4 in homing of fetal liver hematopoietic stem and progenitor cells.

Qian H; Georges-Labouesse E; Nyström A; Domogatskaya A; Tryggvason K; Jacobsen SEW; Ekblom M
Article: BLOOD. 2007;110(4):1362-1369

Potential risks of bone marrow cell transplantation into infarcted hearts.

Breitbach M; Bostani T; Roell W; Xia Y; Dewald O; Nygren JM; Fries JWU; Tiemann K; Bohlen H; Hescheler J; Welz A; Bloch W; Jacobsen SEW; Fleischmann BK
Article: CURRENT OPINION IN HEMATOLOGY. 2007;14(4):315-321

Delineation of the earliest lineage commitment steps of haematopoietic stem cells: new developments, controversies and major challenges.

Buza-Vidas N; Luc S; Jacobsen SEW
Article: BLOOD. 2007;110(1):424-432

Crucial role of FLT3 ligand in immune reconstitution after bone marrow transplantation and high-dose chemotherapy.

Buza-Vidas N; Cheng M; Duarte S; Nozad H; Jacobsen SEW; Sitnicka E
Article: CANCER RESEARCH. 2007;67(12):5727-5736

CD133 is not present on neurogenic astrocytes in the adult subventricular zone, but on embryonic neural stem cells, ependymal cells, and glioblastoma cells.

Pfenninger CV; Roschupkina T; Hertwig F; Kottwitz D; Englund E; Bengzon J; Jacobsen SE; Nuber UA
Article: EMBO JOURNAL. 2007;26(9):2361-2370

Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction.

Fujimoto T; Anderson K; Jacobsen SEW; Nishikawa S-I; Nerlov C
Article: BLOOD. 2007;109(9):3697-3705

Ectopic expression of PAX5 promotes maintenance of biphenotypic myeloid progenitors coexpressing myeloid and B-cell lineage-associated genes.

Anderson K; Rusterholz C; Månsson R; Jensen CT; Bacos K; Zandi S; Sasaki Y; Nerlov C; Sigvardsson M; Jacobsen SEW
Article: IMMUNITY. 2007;26(4):407-419

Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors.

Månsson R; Hultquist A; Luc S; Yang L; Anderson K; Kharazi S; Al-Hashmi S; Liuba K; Thorén L; Adolfsson J; Buza-Vidas N; Qian H; Soneji S; Enver T; Sigvardsson M; Jacobsen SEW
Journal article: BLOOD. 2006;108(11):83

Enforced Expression of GATA-2 Confers Quiescence on Human Hematopoietic Stem and Progenitor Cells In Vitro and In Vivo.

Tipping AJ; Pina C; Castor A; Atzberger A; Hong D; Lazzari L; May G; Jacobsen SE; Enver T
Journal article: BLOOD. 2006;108(11):3208

Crucial Role of FLT3 Ligand in Immune Reconstitution Following Bone Marrow Transplantation and High Dose Chemotherapy.

Buza-Vidas N; Cheng M; Duarte S; Jacobsen SEW; Sitnicka E
Journal article: PLOS BIOLOGY. 2006;4(11):1923-1933

Two-step recruitment of RNA-directed DNA methylation to tandem repeats.

Chan SW-L; Zhang X; Bernatavichute YV; Jacobsen SE
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2006;203(10):2315-2327

Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium.

Kolossov E; Bostani T; Roell W; Breitbach M; Pillekamp F; Nygren JM; Sasse P; Rubenchik O; Fries JWU; Wenzel D; Geisen C; Xia Y; Lu Z; Duan Y; Kettenhofen R; Jovinge S; Bloch W; Bohlen H; Welz A; Hescheler J; Jacobsen SE; Fleischmann BK
Article: NATURE IMMUNOLOGY. 2006;7(10):1048-1056

Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block.

Kirstetter P; Anderson K; Porse BT; Jacobsen SEW; Nerlov C
Journal article: JOURNAL OF CELL BIOLOGY. 2006;174(7):i13

Engraftment of engineered ES cell–derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium

Kolossov E; Bostani T; Roell W; Breitbach M; Pillekamp F; Nygren JM; Sasse P; Rubenchik O; Fries JWU; Wenzel D; Geisen C; Xia Y; Lu Z; Duan Y; Kettenhofen R; Jovinge S; Bloch W; Bohlen H; Welz A; Hescheler J; Jacobsen SE; Fleischmann BK
Article: JOURNAL OF NEUROSCIENCE. 2006;26(38):9703-9712

Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis.

Iosif RE; Ekdahl CT; Ahlenius H; Pronk CJH; Bonde S; Kokaia Z; Jacobsen S-EW; Lindvall O
Article: GENES & DEVELOPMENT. 2006;20(15):2018-2023

Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK.

Buza-Vidas N; Antonchuk J; Qian H; Månsson R; Luc S; Zandi S; Anderson K; Takaki S; Nygren JM; Jensen CT; Jacobsen SEW
Article: JOURNAL OF IMMUNOLOGY. 2006;177(1):201-208

Prolonged cell cycle transit is a defining and developmentally conserved hemopoietic stem cell property.

Nygren JM; Bryder D; Jacobsen SEW
Article: STEM CELLS. 2006;24(6):1594-1604

Failure of transdifferentiation of adult hematopoietic stem cells into neurons.

Roybon L; Ma Z; Asztely F; Fosum A; Jacobsen SEW; Brundin P; Li J-Y
Article: BLOOD. 2006;107(9):3503-3510

Contribution of alpha6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with alpha4 integrins.

Qian H; Tryggvason K; Jacobsen SE; Ekblom M
Article: DIABETES. 2006;55(2):290-296

Failure of transplanted bone marrow cells to adopt a pancreatic beta-cell fate.

Taneera J; Rosengren A; Renstrom E; Nygren JM; Serup P; Rorsman P; Jacobsen SEW
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2005;202(1):85-96

Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage.

Porse BT; Bryder D; Theilgaard-Mönch K; Hasemann MS; Anderson K; Damgaard I; Jacobsen SEW; Nerlov C
Article: NATURE MEDICINE. 2005;11(6):630-637

Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia.

Castor A; Nilsson L; Astrand-Grundström I; Buitenhuis M; Ramirez C; Anderson K; Strömbeck B; Garwicz S; Békássy AN; Schmiegelow K; Lausen B; Hokland P; Lehmann S; Juliusson G; Johansson B; Jacobsen SEW
Article: BLOOD. 2005;105(11):4272-4281

Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2.

Buitenhuis M; van Deutekom HWM; Verhagen LP; Castor A; Jacobsen SEW; Lammers J-WJ; Koenderman L; Coffer PJ
Article: BLOOD. 2005;105(7):2717-2723

Identification of Lin(-)Sca1(+)kit(+)CD34(+)Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients.

Yang L; Bryder D; Adolfsson J; Nygren J; Månsson R; Sigvardsson M; Jacobsen SEW
Article: JOURNAL OF GENE MEDICINE. 2005;7(2):137-144

Deficiency of oncoretrovirally transduced hematopoietic stem cells and correction through ex vivo expansion.

Bryder D; Björgvinsdóttir H; Sasaki Y; Jacobsen SEW
Article: JOURNAL OF IMMUNOLOGY. 2005;174(2):752-757

IFN-gamma negatively modulates self-renewal of repopulating human hemopoietic stem cells.

Yang L; Dybedal I; Bryder D; Nilsson L; Sitnicka E; Sasaki Y; Jacobsen SEW
Article: HAEMATOLOGICA. 2005;90(1):38-44

Biosynthetic profiles of neutrophil serine proteases in a human bone marrow-derived cellular myeloid differentiation model.

Garwicz D; Lennartsson A; Jacobsen SEW; Gullberg U; Lindmark A
Article: GENES CHROMOSOMES & CANCER. 2004;41(3):223-231

MDS/AML-associated cytogenetic abnormalities in multiple myeloma and monoclonal gammopathy of undetermined significance: evidence for frequent de novo occurrence and multipotent stem cell involvement of del(20q).

Nilsson T; Nilsson L; Lenhoff S; Rylander L; Astrand-Grundström I; Strömbeck B; Höglund M; Turesson I; Westin J; Mitelman F; Jacobsen SEW; Johansson B
Article: BLOOD. 2004;104(4):986-992

Enforced expression of cyclin D2 enhances the proliferative potential of myeloid progenitors, accelerates in vivo myeloid reconstitution, and promotes rescue of mice from lethal myeloablation.

Sasaki Y; Jensen CT; Karlsson S; Jacobsen SEW
Article: BMC IMMUNOLOGY. 2004;5:16

P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+ stem and progenitor cells.

Wang L; Jacobsen SEW; Bengtsson A; Erlinge D
Article: NATURE MEDICINE. 2004;10(5):494-501

Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation.

Nygren JM; Jovinge S; Breitbach M; Säwén P; Röll W; Hescheler J; Taneera J; Fleischmann BK; Jacobsen SEW
Article: JOURNAL OF IMMUNOLOGY. 2004;172(3):1548-1552

Deceptive multilineage reconstitution analysis of mice transplanted with hemopoietic stem cells, and implications for assessment of stem cell numbers and lineage potentials.

Bryder D; Sasaki Y; Borge OJ; Jacobsen S-EW
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2003;198(10):1495-1506

Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis.

Sitnicka E; Brakebusch C; Martensson I-L; Svensson M; Agace WW; Sigvardsson M; Buza-Vidas N; Bryder D; Cilio CM; Ahlenius H; Maraskovsky E; Peschon JJ; Jacobsen SEW
Article: BLOOD. 2003;102(3):881-886

Human CD34+ hematopoietic stem cells capable of multilineage engrafting NOD/SCID mice express flt3: distinct flt3 and c-kit expression and response patterns on mouse and candidate human hematopoietic stem cells.

Sitnicka E; Buza-Vidas N; Larsson S; Nygren JM; Liuba K; Jacobsen SEW
Article: BLOOD. 2003;102(1):118-126

Human reconstituting hematopoietic stem cells up-regulate Fas expression upon active cell cycling but remain resistant to Fas-induced suppression.

Dybedal I; Yang L; Bryder D; Aastrand-Grundstrom I; Leandersson K; Jacobsen SEW
Article: BLOOD. 2003;101(3):877-885

Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells.

Gu Y-C; Kortesmaa J; Tryggvason K; Persson J; Ekblom P; Jacobsen S-E; Ekblom M
Article: IMMUNITY. 2002;17(4):463-472

Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool.

Sitnicka E; Bryder D; Theilgaard-Mönch K; Buza-Vidas N; Adolfsson J; Jacobsen SEW
Article: BLOOD. 2002;100(1):259-267

Involvement and functional impairment of the CD34(+)CD38(-)Thy-1(+) hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8.

Nilsson L; Astrand-Grundström I; Anderson K; Arvidsson I; Hokland P; Bryder D; Kjeldsen L; Johansson B; Hellström-Lindberg E; Hast R; Jacobsen SEW
Article: HUMAN GENE THERAPY. 2002;13(9):1061-1073

Efficient oncoretroviral transduction of extended long-term culture-initiating cells and NOD/SCID repopulating cells: enhanced reconstitution with gene-marked cells through an ex vivo expansion approach.

Björgvinsdóttir H; Bryder D; Sitnicka E; Ramsfjell V; De Jong I; Olsson K; Rusterholz C; Karlsson S; Jacobsen SEW
Article: JOURNAL OF IMMUNOLOGY. 2002;168(2):755-762

Transient disruption of autocrine TGF-beta signaling leads to enhanced survival and proliferation potential in single primitive human hemopoietic progenitor cells.

Fan X; Valdimarsdottir G; Larsson J; Brun A; Magnusson M; Jacobsen SE; ten Dijke P; Karlsson S
Article: IMMUNITY. 2001;15(4):659-669

Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity.

Adolfsson J; Borge OJ; Bryder D; Theilgaard-Mönch K; Astrand-Grundström I; Sitnicka E; Sasaki Y; Jacobsen SE
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2001;194(7):941-952

Self-renewal of multipotent long-term repopulating hematopoietic stem cells is negatively regulated by Fas and tumor necrosis factor receptor activation.

Bryder D; Ramsfjell V; Dybedal I; Theilgaard-Mönch K; Högerkorp CM; Adolfsson J; Borge OJ; Jacobsen SE
Article: BLOOD. 2001;98(6):1782-1791

Tumor necrosis factor (TNF)-mediated activation of the p55 TNF receptor negatively regulates maintenance of cycling reconstituting human hematopoietic stem cells.

Dybedal I; Bryder D; Fossum A; Rusten LS; Jacobsen SE
Article: JOURNAL OF VIROLOGY. 2000;74(24):11911-11918

Lentivirus gene transfer in murine hematopoietic progenitor cells is compromised by a delay in proviral integration and results in transduction mosaicism and heterogeneous gene expression in progeny cells.

Mikkola H; Woods NB; Sjögren M; Helgadottir H; Hamaguchi I; Jacobsen SE; Trono D; Karlsson S
Article: BLOOD. 2000;96(12):3725-3733

Lentiviral gene transfer into primary and secondary NOD/SCID repopulating cells.

Woods NB; Fahlman C; Mikkola H; Hamaguchi I; Olsson K; Zufferey R; Jacobsen SE; Trono D; Karlsson S
Article: BLOOD. 2000;96(6):2012-2021

Isolation and characterization of hematopoietic progenitor/stem cells in 5q-deleted myelodysplastic syndromes: evidence for involvement at the hematopoietic stem cell level.

Nilsson L; Astrand-Grundström I; Arvidsson I; Jacobsson B; Hellström-Lindberg E; Hast R; Jacobsen SE
Article: BLOOD. 2000;96(5):1748-1755

Interleukin-3 supports expansion of long-term multilineage repopulating activity after multiple stem cell divisions in vitro.

Bryder D; Jacobsen SE
Article: BLOOD. 2000;96(4):1457-1464

Cloning of human early B-cell factor and identification of target genes suggest a conserved role in B-cell development in man and mouse.

Gisler R; Jacobsen SE; Sigvardsson M
Article: HUMAN GENE THERAPY. 2000;11(9):1313-1327

Efficient adenoviral vector transduction of human hematopoietic SCID-repopulating and long-term culture-initiating cells.

Fan X; Brun A; Segrén S; Jacobsen SE; Karlsson S
Article: BLOOD. 1999;94(12):4093-4102

Distinct requirements for optimal growth and In vitro expansion of human CD34(+)CD38(-) bone marrow long-term culture-initiating cells (LTC-IC), extended LTC-IC, and murine in vivo long-term reconstituting stem cells.

Ramsfjell V; Bryder D; Björgvinsdóttir H; Kornfält S; Nilsson L; Borge OJ; Jacobsen SE
Article: BLOOD. 1999;94(11):3781-3790

Lymphoid-restricted development from multipotent candidate murine stem cells: distinct and complimentary functions of the c-kit and flt3-ligands.

Borge OJ; Adolfsson J; Mårtensson A; Mårtensson IL; Jacobsen SE
Article: BLOOD. 1999;94(6):1971-1978

Involvement of the retinoblastoma protein in monocytic and neutrophilic lineage commitment of human bone marrow progenitor cells.

Bergh G; Ehinger M; Olsson I; Jacobsen SE; Gullberg U
Article: BLOOD. 1997;90(11):4321-4331

Bidirectional effect of interleukin-10 on early murine B-cell development: stimulation of flt3-ligand plus interleukin-7-dependent generation of CD19(-) ProB cells from uncommitted bone marrow progenitor cells and growth inhibition of CD19(+) ProB cells.

Veiby OP; Borge OJ; Mârtensson A; Beck EX; Schade AE; Grzegorzewski K; Lyman SD; Mârtensson IL; Jacobsen SE
Article: BLOOD. 1997;90(9):3395-3403

Transforming growth factor-beta1 abrogates Fas-induced growth suppression and apoptosis of murine bone marrow progenitor cells.

Dybedal I; Guan F; Borge OJ; Veiby OP; Ramsfjell V; Nagata S; Jacobsen SE
Article: BLOOD. 1997;90(6):2282-2292

Ability of early acting cytokines to directly promote survival and suppress apoptosis of human primitive CD34+CD38- bone marrow cells with multilineage potential at the single-cell level: key role of thrombopoietin.

Borge OJ; Ramsfjell V; Cui L; Jacobsen SE
Article: JOURNAL OF IMMUNOLOGY. 1997;159(4):1961-1969

Thrombopoietin promotes adhesion of primitive human hemopoietic cells to fibronectin and vascular cell adhesion molecule-1: role of activation of very late antigen (VLA)-4 and VLA-5.

Cui L; Ramsfjell V; Borge OJ; Veiby OP; Lok S; Jacobsen SE
Article: BLOOD. 1997;89(12):4415-4424

Interleukin-13 in combination with CD40 ligand potently inhibits apoptosis in human B lymphocytes: upregulation of Bcl-xL and Mcl-1.

Lømo J; Blomhoff HK; Jacobsen SE; Krajewski S; Reed JC; Smeland EB
Article: JOURNAL OF IMMUNOLOGY. 1997;158(11):5169-5177

Thrombopoietin directly and potently stimulates multilineage growth and progenitor cell expansion from primitive (CD34+ CD38-) human bone marrow progenitor cells: distinct and key interactions with the ligands for c-kit and flt3, and inhibitory effects of TGF-beta and TNF-alpha.

Ramsfjell V; Borge OJ; Cui L; Jacobsen SE
Article: BLOOD. 1996;88(12):4481-4492

Thrombopoietin, but not erythropoietin, directly stimulates multilineage growth of primitive murine bone marrow progenitor cells in synergy with early acting cytokines: distinct interactions with the ligands for c-kit and FLT3.

Ramsfjell V; Borge OJ; Veiby OP; Cardier J; Murphy MJ; Lyman SD; Lok S; Jacobsen SE
Article: BLOOD. 1996;88(8):2859-2870

Thrombopoietin, but not erythropoietin promotes viability and inhibits apoptosis of multipotent murine hematopoietic progenitor cells in vitro.

Borge OJ; Ramsfjell V; Veiby OP; Murphy MJ; Lok S; Jacobsen SE
Article: JOURNAL OF IMMUNOLOGY. 1996;157(7):2953-2960

The flt3 ligand promotes the survival of primitive hemopoietic progenitor cells with myeloid as well as B lymphoid potential. Suppression of apoptosis and counteraction by TNF-alpha and TGF-beta.

Veiby OP; Jacobsen FW; Cui L; Lyman SD; Jacobsen SE
Article: BLOOD. 1996;88(4):1256-1265

Combined signaling through interleukin-7 receptors and flt3 but not c-kit potently and selectively promotes B-cell commitment and differentiation from uncommitted murine bone marrow progenitor cells.

Veiby OP; Lyman SD; Jacobsen SE
Article: JOURNAL OF IMMUNOLOGY. 1996;157(3):1193-1199

TNF-alpha bidirectionally modulates the viability of primitive murine hematopoietic progenitor cells in vitro.

Jacobsen FW; Veiby OP; Stokke T; Jacobsen SE
Article: BLOOD. 1996;87(12):5016-5026

Ability of flt3 ligand to stimulate the in vitro growth of primitive murine hematopoietic progenitors is potently and directly inhibited by transforming growth factor-beta and tumor necrosis factor-alpha.

Jacobsen SE; Veiby OP; Myklebust J; Okkenhaug C; Lyman SD
Article: BLOOD. 1996;87(5):1728-1736

The RAR-RXR as well as the RXR-RXR pathway is involved in signaling growth inhibition of human CD34+ erythroid progenitor cells.

Rusten LS; Dybedal I; Blomhoff HK; Blomhoff R; Smeland EB; Jacobsen SE
Article: BLOOD. 1996;87(4):1317-1325

The FLT3 ligand is a direct and potent stimulator of the growth of primitive and committed human CD34+ bone marrow progenitor cells in vitro.

Rusten LS; Lyman SD; Veiby OP; Jacobsen SE
Article: STEM CELLS. 1996;14 Suppl 1:163-172

Megakaryocytopoiesis in vitro: from the stem cells' perspective.

Cardier JE; Foster DC; Lok S; Jacobsen SE; Murphy MJ
Article: BLOOD. 1995;86(8):2957-2966

Transforming growth factor-beta potently inhibits the viability-promoting activity of stem cell factor and other cytokines and induces apoptosis of primitive murine hematopoietic progenitor cells.

Jacobsen FW; Stokke T; Jacobsen SE
Article: RESEARCH IN IMMUNOLOGY. 1995;146(7-8):506-514

IL12, a direct stimulator and indirect inhibitor of haematopoiesis.

Jacobsen SE
Article: EXPERIMENTAL HEMATOLOGY. 1995;23(9):990-995

Direct synergistic effects of IL-4 and IL-11 on proliferation of primitive hematopoietic progenitor cells.

Jacobsen FW; Keller JR; Ruscetti FW; Veiby OP; Jacobsen SE
Article: BLOOD. 1995;86(3):949-957

Transforming growth factor beta (TGF-beta), a potent inhibitor of erythropoiesis: neutralizing TGF-beta antibodies show erythropoietin as a potent stimulator of murine burst-forming unit erythroid colony formation in the absence of a burst-promoting activity.

Dybedal I; Jacobsen SE
Article: JOURNAL OF IMMUNOLOGY. 1995;155(1):58-65

All-trans- and 9-cis-retinoic acid inhibit growth of normal human and murine B cell precursors.

Fahlman C; Jacobsen SE; Smeland EB; Lømo J; Naess CE; Funderud S; Blomhoff HK
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 1995;7(1):45-50

Retinoic Acid potently stimulates the production of granulocyte-colony-stimulating factor in the human monocytic thp-1 cell-line.

Wang Y; Garg M; Guan F; Dai W; Jacobsen S; Murphy M
Article: JOURNAL OF IMMUNOLOGY. 1995;154(10):4950-4955

IL-12 directly enhances in vitro murine erythropoiesis in combination with IL-4 and stem cell factor.

Dybedal I; Larsen S; Jacobsen SE
Article: JOURNAL OF IMMUNOLOGY. 1995;154(8):3732-3741

Inhibition of stem cell factor-induced proliferation of primitive murine hematopoietic progenitor cells signaled through the 75-kilodalton tumor necrosis factor receptor. Regulation of c-kit and p53 expression.

Jacobsen FW; Dubois CM; Rusten LS; Veiby OP; Jacobsen SE
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 1995;181(4):1357-1363

The FLT3 ligand potently and directly stimulates the growth and expansion of primitive murine bone marrow progenitor cells in vitro: synergistic interactions with interleukin (IL) 11, IL-12, and other hematopoietic growth factors.

Jacobsen SE; Okkenhaug C; Myklebust J; Veiby OP; Lyman SD
Article: BLOOD. 1995;85(4):989-996

Tumor necrosis factor (TNF)-alpha directly inhibits human erythropoiesis in vitro: role of p55 and p75 TNF receptors.

Rusten LS; Jacobsen SE
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Letter: CELL RESEARCH. 2023;33(11):883-886

Platelet and myeloid lineage biases of transplanted single perinatal mouse hematopoietic stem cells.

Belander Strålin K; Carrelha J; Winroth A; Ziegenhain C; Hagemann-Jensen M; Kettyle LM; Hillen A; Högstrand K; Markljung E; Grasso F; Seki M; Mazzi S; Meng Y; Wu B; Chari E; Lehander M; Sandberg R; Woll PS; Jacobsen SEW
Letter: BLOOD ADVANCES. 2022;6(16):4705-4709

The extent of residual WT HSPCs is associated with the degree of anemia in patients with SF3B1-mutated MDS-RS.

Hofman IJF; Mortera-Blanco T; Moura PL; Vestlund J; Larsson SV; Elvarsdottir EM; Walldin G; Tobiasson M; Sander B; Dimitriou M; Jacobsen S-EW; Woll PS; Jädersten M; Hellström-Lindberg E
Review: JOURNAL OF INTERNAL MEDICINE. 2022;292(2):262-277

Targeting stem cells in myelodysplastic syndromes and acute myeloid leukemia.

Woll PS; Yoshizato T; Hellström-Lindberg E; Fioretos T; Ebert BL; Jacobsen SEW
Corrigendum: CANCER CELL. 2014;25(6):861

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo (vol 25, pg 794, 2014)

Woll PS; Kjaellquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstroem-Lindberg E; Linnarsson S; Jacobsen SEW
Editorial comment: ONCOTARGET. 2013;4(6):814-815

Germline counterparts of oncogenic mutations: who gives a JAK?

Mead AJ; Constantinescu SN; Jacobsen SE
Corrigendum: NATURE CELL BIOLOGY. 2013;15(5):544

Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis (vol 15, pg 363, 2013)

Moignard V; Macaulay IC; Swiers G; Buettner F; Schuette J; Calero-Nieto FJ; Kinston S; Joshi A; Hannah R; Theis FJ; Jacobsen SE; de Bruijn MF; Goettgens B
Letter: LEUKEMIA. 2013;27(5):1204-1207

Quiescent leukaemic cells account for minimal residual disease in childhood lymphoblastic leukaemia.

Lutz C; Woll PS; Hall G; Castor A; Dreau H; Cazzaniga G; Zuna J; Jensen C; Clark SA; Biondi A; Mitchell C; Ferry H; Schuh A; Buckle V; Jacobsen S-EW; Enver T
Letter: NEW ENGLAND JOURNAL OF MEDICINE. 2012;366(10):967-969

Germline JAK2 mutation in a family with hereditary thrombocytosis.

Mead AJ; Rugless MJ; Jacobsen SEW; Schuh A
Editorial comment: CELL STEM CELL. 2011;8(3):242-244

Clever leukemic stem cells branch out.

Vyas P; Jacobsen SEW
Editorial comment: NATURE. 2009;461(7261):183-184

Developmental biology: Instructions writ in blood.

Enver T; Jacobsen SEW
Review: SEMINARS IN IMMUNOLOGY. 2008;20(4):213-220

Delineating the cellular pathways of hematopoietic lineage commitment.

Luc S; Buza-Vidas N; Jacobsen SEW
Letter: NATURE IMMUNOLOGY. 2007;8(9):897

TSLP-mediated fetal B lymphopoiesis?

Jensen CT; Kharazi S; Böiers C; Liuba K; Jacobsen SEW
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2007;1106:89-94

Biological and molecular evidence for existence of lymphoid-primed multipotent progenitors.

Luc S; Buza-Vidas N; Jacobsen SEW
Conference publication: BLOOD. 2007;110(11):661A

Downregulation of Mpl marks the transition to lymphoid-primed multipotent progenitors with gradual loss of granulocyte-monocyte potential

Luc S; Anderson K; Kharazi S; Buza-Vidas N; Boiers C; Jensen CT; Ma Z; Wittman L; Jacobsen SEW
Meeting abstract: BLOOD. 2006;108(11):109A

Distinct roles of integrins α6 and α4 in fetal liver hematopoietic stem and progenitor cell homing.

Qian H; Georges-Labouesse E; Nystrom A; Domogatskaya A; Tryggvason K; Eirik S; Jacobsen W; Ekblom M
Conference publication: BLOOD. 2006;108(11):29A

Enforced expression of GATA-2 confers quiescence on human hematopoietic stem and progenitor cells in in vitro and in vivo.

Tipping AJ; Pina C; Castor A; Atzberger A; Hong D; Lazzari L; May G; Jacobsen SE; Enver T
Editorial comment: NATURE IMMUNOLOGY. 2005;6(3):234-236

Defining 'stemness': Notch and Wnt join forces?

Jacobsen SEW
Review: BLOOD. 1998;91(4):1101-1134

c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities.

Lyman SD; Jacobsen SE
Review: STEM CELLS. 1996;14 Suppl 1:173-180

Thrombopoietin, a direct stimulator of viability and multilineage growth of primitive bone marrow progenitor cells.

Jacobsen SE; Borge OJ; Ramsfjell V; Cui L; Cardier JE; Veiby OP; Murphy MJ; Lok S
Other: JOURNAL OF EXPERIMENTAL MEDICINE. 1995;181(1):369-374

Mobilization of long-term reconstituting hematopoietic stem cells in mice by recombinant human interleukin 7.

Grzegorzewski KJ; Komschlies KL; Jacobsen SE; Ruscetti FW; Keller JR; Wiltrout RH

Grants

Role of Stem Cells in Normal and Malignant Hematopoiesis

Swedish Research Council

1 December 2023 - 30 November 2028
Characterization, Surveillance and Targeting of Cancer Stem Cells

Knut and Alice Wallenberg Foundation

1 January 2016 - 1 January 2021

Employments

Part-time Professor of Stem Cell Biology and Regenerative Medicine, Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, 2015-
Professor/Senior Physician, Department of Cell and Molecular Biology, Karolinska Institutet, 2014-
Professor/Senior Physician, Department of Medicine, Huddinge, Karolinska Institutet, 2014-

About me

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