Shilpa Ray
Forskningsspecialist
E-postadress: shilpa.ray@ki.se
Besöksadress: ANA Futura Laboratory, Alfred Nobels väg 8, 14152 Huddinge
Postadress: H7 Medicin, Huddinge, H7 CIM-CID Sönnerborg Ray, 171 77 Stockholm
Del av:
- Institutionen för medicin, Huddinge
- Translationell forskning på humana mikrobiella infektioner och dess kliniska konsekvenser – Anders Sönnerborgs grupp
Artiklar
- Article: SCIENTIFIC REPORTS. 2024;14(1):17820Narayanan A; Kieri O; Vesterbacka J; Manoharan L; Chen P; Ghorbani M; Ljunggren H-G; Chen MS; Aleman S; Soennerborg A; Ray S; Nowak P
- Article: NPJ BIOFILMS AND MICROBIOMES. 2023;9(1):104Ray S; Narayanan A; Vesterbacka J; Blennow O; Chen P; Gao Y; Gabarrini G; Ljunggren H-G; Buggert M; Manoharan L; Chen MS; Aleman S; Sonnerborg A; Nowak P
- Article: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. 2023;61(5):106792Cena-Diez R; Narayanan A; Ray S; van de Klundert M; Rodriguez JE; Nilvebrant J; Nygren P-A; Vegvari A; van Domselaar R; Sonnerborg A
- Article: FRONTIERS IN IMMUNOLOGY. 2023;13:1079995Ghorbani M; Al-Manei K; Naud S; Healy K; Gabarrini G; Sobkowiak MJ; Chen P; Ray S; Akber M; Muschiol S; Bogdanovic G; Bergman P; Ljungman P; Buggert M; Ljunggren H-G; Pin E; Nowak P; Aleman S; Saellberg Chen M
- Article: PROTEIN SCIENCE. 2022;31(4):835-849Ray S; Pandey NK; Kushwaha GS; Das S; Ganguly AK; Vashi N; Kumar D; Suar M; Bhavesh NS
- Article: JOURNAL OF VIROLOGY. 2021;95(18):e0047921-10.1128/jvi.00421Sperk M; Ambikan AT; Ray S; Singh K; Mikaeloff F; Diez RC; Narayanan A; Vesterbacka J; Nowak P; Sonnerborg A; Neogi U
- Article: FRONTIERS IN MICROBIOLOGY. 2021;12:667718Bai X; Narayanan A; Nowak P; Ray S; Neogi U; Sonnerborg A
- Article: ACS INFECTIOUS DISEASES. 2021;7(5):1104-1115Ray S; Narayanan A; Giske CG; Neogi U; Sonnerborg A; Nowak P
- Journal article: VIRULENCE. 2020;11(1):247-259Das S; Ray S; Arunima A; Sahu B; Suar M
- Journal article: VIRULENCE. 2020;11(1):295-314Arunima A; Swain SK; Ray S; Prusty BK; Suar M
- Journal article: VIRULENCE. 2018;9(1):348-362Das S; Ray S; Ryan D; Sahu B; Suar M
- Journal article: GUT PATHOGENS. 2018;10:30Ray S; Das S; Panda PK; Suar M
- Journal article: SCIENTIFIC REPORTS. 2016;6:38204Jaiswal S; Paul P; Padhi C; Ray S; Ryan D; Dash S; Suar M
- Journal article: APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 2015;81(23):8054-8065Ryan D; Pati NB; Ojha UK; Padhi C; Ray S; Jaiswal S; Singh GP; Mannala GK; Schultze T; Chakraborty T; Suar M
- Journal article: VACCINE. 2015;33(15):1880-1889Vishwakarma V; Sahoo SS; Das S; Ray S; Hardt W-D; Suar M
- Journal article: GUT PATHOGENS. 2015;7:24Jaiswal S; Pati NB; Dubey M; Padhi C; Sahoo PK; Ray S; Arunima A; Mohakud NK; Suar M
- Journal article: VIRULENCE. 2014;5(2):311-320Vishwakarma V; Pati NB; Ray S; Das S; Suar M
Alla övriga publikationer
- Preprint: RESEARCH SQUARE. 2024Narayanan A; Kieri O; Vesterbacka J; Manoharan L; Chen P; Ghorbani M; Ljunggren H-G; Chen MS; Aleman S; Sönnerborg A; Ray S; Nowak P
- Preprint: RESEARCH SQUARE. 2023Ray S; Narayanan A; Vesterbacka J; Blennow O; Chen P; Gao Y; Gabarrini G; Ljunggren H-G; Buggert M; Manoharan L; Chen M; Aleman S; Sönnerborg A; Nowak P
- Preprint: RESEARCH SQUARE. 2020Sperk M; Ambikan A; Ray S; Singh K; Mikaeloff F; Diez RC; Narayanan A; Vesterbacka J; Nowak P; Sönnerborg A; Neogi U
Forskningsbidrag
- Region Stockholm (CIMED Junioransökan)1 January 2025 - 31 December 2027
- Impact of metabolites and bacterial signatures on gut epithelial integrity in HIV infected Elite controllersKI - Karolinska Institutet Research Foundation Grants1 January 2025 - 31 December 2025
- Region Stockholm (CIMED Senioransökan)1 January 2025 - 31 December 2027
- Swedish Research Council1 January 2023 - 31 December 2025To stem the ever-growing threat of antimicrobial resistance (AMR), our research focuses on non-antibiotic strategies to combat multi-drug resistant (MDR) pathogens. We have developed up to the preclinical stage an inhibitor, 3A11, which is the first targeting copper-transporting P-type ATPase protein CopA. It limits the growth of several Gram-positive pathogens, such as Staphylococcus aureus , Enterococcus faecalis , Enterococcus faecium , and the two most common MDR strains causing nosocomial infections: methicillin-resistant S. aureus and vancomycin-resistant enterococci. We will collect sequenced clinical isolates from the vast bacterial repositories of our project partners to test the bactericidal potential of 3A11.The inclusion of clinical isolates with different phenotypes and genetic lineages will guide our investigations of the underlying molecular mechanisms of action. This will be further studied using transcriptomic analysis to determine changes in the global expression profiles of the isolates induced by 3A11. As part of the preclinical development, we will investigate the potential development of resistance to 3A11 by determining the mutation rates in the bacteria and further characterizing the ensuing phenotypes, genotypes, and fitness cost. Lastly, we will gauge the efficacy of 3A11 in cell-lines like, human keratinocytes (HaCaT), primary keratinocytes, human macrophage cells (THP-1), and in murine models to investigate 3A11´s role in bacterial pathogenesis.
- Stiftelsen Läkare mot AIDS Forskningsfond1 November 2021 - 31 July 2022
- Are microbiome changes responsible for the weight gain in individuals treated with dolutegravir?Karolinska Institutet Foundation for Virus Research1 April 2021 - 31 December 2022
- Åke Wibergs Stiftelse1 January 2021 - 31 December 2023
- Can antiretroviral drugs be used to treat antibiotic-resistant bacteria?KI - Karolinska Institutet Research Foundation Grants1 January 2021 - 1 January 2022