Shilpa Ray

Shilpa Ray

Research Specialist
Visiting address: ANA Futura Laboratory, Alfred Nobels väg 8, 14152 Huddinge
Postal address: H7 Medicin, Huddinge, H7 CIM-CID Sönnerborg Ray, 171 77 Stockholm
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About me

  • Shilpa received her Ph.D. in November 2018 from KIIT University, India, on the identification of serovar-specific virulence factors contributing to the pathogenesis of Salmonella Typhimurium and Salmonella Enteritidis. She joined KI as a postdoctoral researcher in February 2019. Since then, her research has been aimed primarily at understanding the interactions between antiretroviral drugs and gut microbiome in HIV-infected patients and their underlying molecular mechanisms by integrating systems biology approaches with in vitro work. As a postdoctoral researcher, Shilpa expanded her research interests and developed them into independent research topics diverse but complementary to those of her group. Altogether, these topics and her studies aim at reducing bacterial infections, particularly nosocomial ones, caused by antimicrobial resistant bacteria. This includes developing, screening, testing, and repurposing drugs into new antibacterial agents as well as investigating their mechanisms of action and host–pathogen interactions. In 2023, supported by several prestigious competitive research grants obtained during her postdoctoral training (2019–2022) and subsequent research specialist position (2023 onwards), she became a team leader. She currently leads investigations into the microbiome and bacterial infections, with a particular focus on antimicrobial resistance, host–pathogen interactions, and the development of novel therapeutic strategies within her group.

Research

  • Antimicrobial resistance (AMR), Host-pathogen interactions, Gut microbiome patterns in treated HIV patients

Articles

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Grants

  • Impact of metabolites and bacterial signatures on gut epithelial integrity in HIV infected Elite controllers
    KI - Karolinska Institutet Research Foundation Grants
    1 January 2025 - 31 December 2025
  • Region Stockholm (CIMED Senioransökan)
    1 January 2025 - 31 December 2027
  • Swedish Research Council
    1 January 2023 - 31 December 2025
    To stem the ever-growing threat of antimicrobial resistance (AMR), our research focuses on non-antibiotic strategies to combat multi-drug resistant (MDR) pathogens. We have developed up to the preclinical stage an inhibitor, 3A11, which is the first targeting copper-transporting P-type ATPase protein CopA. It limits the growth of several Gram-positive pathogens, such as Staphylococcus aureus , Enterococcus faecalis , Enterococcus faecium , and the two most common MDR strains causing nosocomial infections: methicillin-resistant S. aureus and vancomycin-resistant enterococci. We will collect sequenced clinical isolates from the vast bacterial repositories of our project partners to test the bactericidal potential of 3A11.The inclusion of clinical isolates with different phenotypes and genetic lineages will guide our investigations of the underlying molecular mechanisms of action. This will be further studied using transcriptomic analysis to determine changes in the global expression profiles of the isolates induced by 3A11. As part of the preclinical development, we will investigate the potential development of resistance to 3A11 by determining the mutation rates in the bacteria and further characterizing the ensuing phenotypes, genotypes, and fitness cost. Lastly, we will gauge the efficacy of 3A11 in cell-lines like, human keratinocytes (HaCaT), primary keratinocytes, human macrophage cells (THP-1), and in murine models to investigate 3A11´s role in bacterial pathogenesis.
  • Stiftelsen Läkare mot AIDS Forskningsfond
    1 November 2021 - 31 July 2022
  • Are microbiome changes responsible for the weight gain in individuals treated with dolutegravir?
    Karolinska Institutet Foundation for Virus Research
    1 April 2021 - 31 December 2022
  • Åke Wibergs Stiftelse
    1 January 2021 - 31 December 2023
  • Can antiretroviral drugs be used to treat antibiotic-resistant bacteria?
    KI - Karolinska Institutet Research Foundation Grants
    1 January 2021 - 1 January 2022

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